GPCRdb

Ligand source activities (1 row/activity)

Potency
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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	1323	2669	55	None	-58	8	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.2c00793
	92432	2669	55	None	-58	8	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.2c00793
	CHEMBL430239	2669	55	None	-58	8	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.2c00793
	1323	2669	55	None	-58	8	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00095
	92432	2669	55	None	-58	8	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00095
	CHEMBL430239	2669	55	None	-58	8	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00095
	1324	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cellsAgonist activity at mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm701093y
	16154396	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cellsAgonist activity at mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm701093y
	16197727	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cellsAgonist activity at mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm701093y
	44285019	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cellsAgonist activity at mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm701093y
	57514683	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cellsAgonist activity at mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm701093y
	91898441	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cellsAgonist activity at mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm701093y
	CHEMBL441738	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cellsAgonist activity at mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm701093y
	DB04931	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cellsAgonist activity at mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm701093y
	CHEMBL413212	213032	0	None	-3	4	Human	10.2	pEC50	=	10.2	Functional	Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm00018a005
	1324	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	1324	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.0c00561
	16154396	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	16154396	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.0c00561
	16197727	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	16197727	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.0c00561
	44285019	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	44285019	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.0c00561
	57514683	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	57514683	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.0c00561
	91898441	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	91898441	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.0c00561
	CHEMBL441738	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	CHEMBL441738	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.0c00561
	DB04931	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	DB04931	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.0c00561
	1324	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0490843
	16154396	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0490843
	16197727	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0490843
	44285019	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0490843
	57514683	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0490843
	91898441	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0490843
	CHEMBL441738	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0490843
	DB04931	301	25	None	-6	9	Mouse	10.2	pEC50	=	10.2	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0490843
	1324	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP level incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP level incubated for 2 hr by alphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01417
	16154396	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP level incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP level incubated for 2 hr by alphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01417
	16197727	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP level incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP level incubated for 2 hr by alphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01417
	44285019	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP level incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP level incubated for 2 hr by alphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01417
	57514683	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP level incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP level incubated for 2 hr by alphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01417
	91898441	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP level incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP level incubated for 2 hr by alphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01417
	CHEMBL441738	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP level incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP level incubated for 2 hr by alphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01417
	DB04931	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP level incubated for 2 hr by alphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP level incubated for 2 hr by alphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01417
	1324	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		None	10.1021/jm0492756
	16154396	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		None	10.1021/jm0492756
	16197727	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		None	10.1021/jm0492756
	44285019	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		None	10.1021/jm0492756
	57514683	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		None	10.1021/jm0492756
	91898441	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		None	10.1021/jm0492756
	CHEMBL441738	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		None	10.1021/jm0492756
	DB04931	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		None	10.1021/jm0492756
	1324	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R by alphascreen cAMP assayAgonist activity at mouse MC3R by alphascreen cAMP assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00641
	16154396	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R by alphascreen cAMP assayAgonist activity at mouse MC3R by alphascreen cAMP assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00641
	16197727	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R by alphascreen cAMP assayAgonist activity at mouse MC3R by alphascreen cAMP assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00641
	44285019	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R by alphascreen cAMP assayAgonist activity at mouse MC3R by alphascreen cAMP assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00641
	57514683	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R by alphascreen cAMP assayAgonist activity at mouse MC3R by alphascreen cAMP assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00641
	91898441	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R by alphascreen cAMP assayAgonist activity at mouse MC3R by alphascreen cAMP assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00641
	CHEMBL441738	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R by alphascreen cAMP assayAgonist activity at mouse MC3R by alphascreen cAMP assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00641
	DB04931	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R by alphascreen cAMP assayAgonist activity at mouse MC3R by alphascreen cAMP assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00641
	1324	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.6b01707
	16154396	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.6b01707
	16197727	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.6b01707
	44285019	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.6b01707
	57514683	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.6b01707
	91898441	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.6b01707
	CHEMBL441738	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.6b01707
	DB04931	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.6b01707
	1324	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00301
	16154396	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00301
	16197727	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00301
	44285019	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00301
	57514683	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00301
	91898441	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00301
	CHEMBL441738	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00301
	DB04931	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00301
	1324	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL		None	None	None		None	10.1016/j.bmcl.2009.07.025
	16154396	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL		None	None	None		None	10.1016/j.bmcl.2009.07.025
	16197727	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL		None	None	None		None	10.1016/j.bmcl.2009.07.025
	44285019	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL		None	None	None		None	10.1016/j.bmcl.2009.07.025
	57514683	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL		None	None	None		None	10.1016/j.bmcl.2009.07.025
	91898441	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL		None	None	None		None	10.1016/j.bmcl.2009.07.025
	CHEMBL441738	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL		None	None	None		None	10.1016/j.bmcl.2009.07.025
	DB04931	301	25	None	-6	9	Mouse	10.1	pEC50	=	10.1	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL		None	None	None		None	10.1016/j.bmcl.2009.07.025
	1324	301	25	None	-6	9	Mouse	10.0	pEC50	=	10.0	Functional	Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)	ChEMBL		None	None	None		None	10.1021/jm010524p
	16154396	301	25	None	-6	9	Mouse	10.0	pEC50	=	10.0	Functional	Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)	ChEMBL		None	None	None		None	10.1021/jm010524p
	16197727	301	25	None	-6	9	Mouse	10.0	pEC50	=	10.0	Functional	Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)	ChEMBL		None	None	None		None	10.1021/jm010524p
	44285019	301	25	None	-6	9	Mouse	10.0	pEC50	=	10.0	Functional	Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)	ChEMBL		None	None	None		None	10.1021/jm010524p
	57514683	301	25	None	-6	9	Mouse	10.0	pEC50	=	10.0	Functional	Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)	ChEMBL		None	None	None		None	10.1021/jm010524p
	91898441	301	25	None	-6	9	Mouse	10.0	pEC50	=	10.0	Functional	Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)	ChEMBL		None	None	None		None	10.1021/jm010524p
	CHEMBL441738	301	25	None	-6	9	Mouse	10.0	pEC50	=	10.0	Functional	Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)	ChEMBL		None	None	None		None	10.1021/jm010524p
	DB04931	301	25	None	-6	9	Mouse	10.0	pEC50	=	10.0	Functional	Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)	ChEMBL		None	None	None		None	10.1021/jm010524p
	1324	301	25	None	-6	9	Mouse	10.0	pEC50	=	10.0	Functional	Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0303608
	16154396	301	25	None	-6	9	Mouse	10.0	pEC50	=	10.0	Functional	Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0303608
	16197727	301	25	None	-6	9	Mouse	10.0	pEC50	=	10.0	Functional	Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0303608
	44285019	301	25	None	-6	9	Mouse	10.0	pEC50	=	10.0	Functional	Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0303608
	57514683	301	25	None	-6	9	Mouse	10.0	pEC50	=	10.0	Functional	Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0303608
	91898441	301	25	None	-6	9	Mouse	10.0	pEC50	=	10.0	Functional	Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0303608
	CHEMBL441738	301	25	None	-6	9	Mouse	10.0	pEC50	=	10.0	Functional	Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0303608
	DB04931	301	25	None	-6	9	Mouse	10.0	pEC50	=	10.0	Functional	Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0303608
	1324	301	25	None	-6	9	Mouse	10.0	pEC50	=	10	Functional	Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm010061n
	16154396	301	25	None	-6	9	Mouse	10.0	pEC50	=	10	Functional	Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm010061n
	16197727	301	25	None	-6	9	Mouse	10.0	pEC50	=	10	Functional	Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm010061n
	44285019	301	25	None	-6	9	Mouse	10.0	pEC50	=	10	Functional	Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm010061n
	57514683	301	25	None	-6	9	Mouse	10.0	pEC50	=	10	Functional	Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm010061n
	91898441	301	25	None	-6	9	Mouse	10.0	pEC50	=	10	Functional	Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm010061n
	CHEMBL441738	301	25	None	-6	9	Mouse	10.0	pEC50	=	10	Functional	Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm010061n
	DB04931	301	25	None	-6	9	Mouse	10.0	pEC50	=	10	Functional	Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm010061n
	1324	301	25	None	-1	9	Rat	10.0	pEC50	=	10	Functional	Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R)	ChEMBL		None	None	None		None	10.1021/jm030452x
	16154396	301	25	None	-1	9	Rat	10.0	pEC50	=	10	Functional	Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R)	ChEMBL		None	None	None		None	10.1021/jm030452x
	16197727	301	25	None	-1	9	Rat	10.0	pEC50	=	10	Functional	Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R)	ChEMBL		None	None	None		None	10.1021/jm030452x
	44285019	301	25	None	-1	9	Rat	10.0	pEC50	=	10	Functional	Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R)	ChEMBL		None	None	None		None	10.1021/jm030452x
	57514683	301	25	None	-1	9	Rat	10.0	pEC50	=	10	Functional	Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R)	ChEMBL		None	None	None		None	10.1021/jm030452x
	91898441	301	25	None	-1	9	Rat	10.0	pEC50	=	10	Functional	Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R)	ChEMBL		None	None	None		None	10.1021/jm030452x
	CHEMBL441738	301	25	None	-1	9	Rat	10.0	pEC50	=	10	Functional	Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R)	ChEMBL		None	None	None		None	10.1021/jm030452x
	DB04931	301	25	None	-1	9	Rat	10.0	pEC50	=	10	Functional	Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R)	ChEMBL		None	None	None		None	10.1021/jm030452x
	168284256	190922	0	None	-2	4	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2383	48	33	31	-4.2	CCCC[C@@H]1NC(=O)[C@@H]2CSC/C(=N/OCC(=O)NCCOCCOCCOCCN=[N+]=[N-])CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5185775	190922	0	None	-2	4	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2383	48	33	31	-4.2	CCCC[C@@H]1NC(=O)[C@@H]2CSC/C(=N/OCC(=O)NCCOCCOCCOCCN=[N+]=[N-])CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	168281421	190933	0	None	10	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2430	43	34	31	-3.4	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCN)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5185945	190933	0	None	10	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2430	43	34	31	-3.4	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCN)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL429236	213493	0	None	-5	4	Mouse	10.0	pEC50	=	10.0	Functional	Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm010061n
	1324	301	25	None	-15	9	Human	9.9	pEC50	=	9.9	Functional	Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm00018a005
	16154396	301	25	None	-15	9	Human	9.9	pEC50	=	9.9	Functional	Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm00018a005
	16197727	301	25	None	-15	9	Human	9.9	pEC50	=	9.9	Functional	Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm00018a005
	44285019	301	25	None	-15	9	Human	9.9	pEC50	=	9.9	Functional	Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm00018a005
	57514683	301	25	None	-15	9	Human	9.9	pEC50	=	9.9	Functional	Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm00018a005
	91898441	301	25	None	-15	9	Human	9.9	pEC50	=	9.9	Functional	Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm00018a005
	CHEMBL441738	301	25	None	-15	9	Human	9.9	pEC50	=	9.9	Functional	Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm00018a005
	DB04931	301	25	None	-15	9	Human	9.9	pEC50	=	9.9	Functional	Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm00018a005
	1324	301	25	None	-6	9	Mouse	9.9	pEC50	=	9.9	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm101425m
	16154396	301	25	None	-6	9	Mouse	9.9	pEC50	=	9.9	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm101425m
	16197727	301	25	None	-6	9	Mouse	9.9	pEC50	=	9.9	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm101425m
	44285019	301	25	None	-6	9	Mouse	9.9	pEC50	=	9.9	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm101425m
	57514683	301	25	None	-6	9	Mouse	9.9	pEC50	=	9.9	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm101425m
	91898441	301	25	None	-6	9	Mouse	9.9	pEC50	=	9.9	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm101425m
	CHEMBL441738	301	25	None	-6	9	Mouse	9.9	pEC50	=	9.9	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm101425m
	DB04931	301	25	None	-6	9	Mouse	9.9	pEC50	=	9.9	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm101425m
	127036484	136420	0	None	-3	4	Mouse	9.8	pEC50	=	9.8	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assay	ChEMBL	1024	17	14	11	-1.0	CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1016/j.bmcl.2015.10.095
	CHEMBL3735690	136420	0	None	-3	4	Mouse	9.8	pEC50	=	9.8	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assay	ChEMBL	1024	17	14	11	-1.0	CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1016/j.bmcl.2015.10.095
	11993702	3566	18	None	1	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.2c00793
	5416	3566	18	None	1	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.2c00793
	9272	3566	18	None	1	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.2c00793
	CHEMBL3301624	3566	18	None	1	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.2c00793
	DB11700	3566	18	None	1	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.2c00793
	11993702	3566	18	None	1	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00095
	5416	3566	18	None	1	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00095
	9272	3566	18	None	1	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00095
	CHEMBL3301624	3566	18	None	1	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00095
	DB11700	3566	18	None	1	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00095
	168271934	190061	0	None	-1	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2229	37	32	26	-3.7	C#CCCCCN1C(=O)C2=C(SC[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](CS2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2c[nH]c4ccccc24)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC3=O)C1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5172738	190061	0	None	-1	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2229	37	32	26	-3.7	C#CCCCCN1C(=O)C2=C(SC[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](CS2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2c[nH]c4ccccc24)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC3=O)C1=O	10.1021/acs.jmedchem.2c00793
	1323	2669	55	None	-5	8	Mouse	9.8	pEC50	=	9.8	Functional	Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)	ChEMBL		None	None	None		None	10.1021/jm010524p
	92432	2669	55	None	-5	8	Mouse	9.8	pEC50	=	9.8	Functional	Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)	ChEMBL		None	None	None		None	10.1021/jm010524p
	CHEMBL430239	2669	55	None	-5	8	Mouse	9.8	pEC50	=	9.8	Functional	Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)	ChEMBL		None	None	None		None	10.1021/jm010524p
	44310104	81559	0	None	-7	4	Mouse	9.8	pEC50	=	9.8	Functional	Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor	ChEMBL	1040	16	13	13	-1.5	CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CC(=O)ONCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm0303608
	CHEMBL216295	81559	0	None	-7	4	Mouse	9.8	pEC50	=	9.8	Functional	Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor	ChEMBL	1040	16	13	13	-1.5	CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CC(=O)ONCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm0303608
	CHEMBL386081	212352	0	None	-8	4	Mouse	9.8	pEC50	=	9.8	Functional	Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm010061n
	1323	2669	55	None	-5	8	Mouse	9.8	pEC50	=	9.8	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		None	10.1021/jm0492756
	92432	2669	55	None	-5	8	Mouse	9.8	pEC50	=	9.8	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		None	10.1021/jm0492756
	CHEMBL430239	2669	55	None	-5	8	Mouse	9.8	pEC50	=	9.8	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		None	10.1021/jm0492756
	1323	2669	55	None	-5	8	Mouse	9.7	pEC50	=	9.7	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm501027w
	92432	2669	55	None	-5	8	Mouse	9.7	pEC50	=	9.7	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm501027w
	CHEMBL430239	2669	55	None	-5	8	Mouse	9.7	pEC50	=	9.7	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm501027w
	127036484	136420	0	None	-3	4	Mouse	9.7	pEC50	=	9.7	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assay	ChEMBL	1024	17	14	11	-1.0	CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1016/j.bmcl.2015.10.095
	CHEMBL3735690	136420	0	None	-3	4	Mouse	9.7	pEC50	=	9.7	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assay	ChEMBL	1024	17	14	11	-1.0	CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1016/j.bmcl.2015.10.095
	168289404	191288	0	None	-4	4	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2134	33	32	28	-5.0	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(nn3)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5191309	191288	0	None	-4	4	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2134	33	32	28	-5.0	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(nn3)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	1324	301	25	None	-6	9	Mouse	9.7	pEC50	=	9.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00856
	16154396	301	25	None	-6	9	Mouse	9.7	pEC50	=	9.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00856
	16197727	301	25	None	-6	9	Mouse	9.7	pEC50	=	9.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00856
	44285019	301	25	None	-6	9	Mouse	9.7	pEC50	=	9.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00856
	57514683	301	25	None	-6	9	Mouse	9.7	pEC50	=	9.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00856
	91898441	301	25	None	-6	9	Mouse	9.7	pEC50	=	9.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00856
	CHEMBL441738	301	25	None	-6	9	Mouse	9.7	pEC50	=	9.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00856
	DB04931	301	25	None	-6	9	Mouse	9.7	pEC50	=	9.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as increase in cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00856
	1324	301	25	None	-6	9	Mouse	9.7	pEC50	=	9.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00198
	16154396	301	25	None	-6	9	Mouse	9.7	pEC50	=	9.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00198
	16197727	301	25	None	-6	9	Mouse	9.7	pEC50	=	9.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00198
	44285019	301	25	None	-6	9	Mouse	9.7	pEC50	=	9.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00198
	57514683	301	25	None	-6	9	Mouse	9.7	pEC50	=	9.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00198
	91898441	301	25	None	-6	9	Mouse	9.7	pEC50	=	9.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00198
	CHEMBL441738	301	25	None	-6	9	Mouse	9.7	pEC50	=	9.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00198
	DB04931	301	25	None	-6	9	Mouse	9.7	pEC50	=	9.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		None	10.1021/acsmedchemlett.9b00198
	CHEMBL428615	213437	0	None	-10	5	Human	9.7	pEC50	=	9.7	Functional	Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm00018a005
	118722938	116213	0	None	-2	4	Mouse	9.7	pEC50	=	9.7	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCCc2cn(nn2)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL3358546	116213	0	None	-2	4	Mouse	9.7	pEC50	=	9.7	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCCc2cn(nn2)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	118722941	116216	0	None	-4	4	Mouse	9.7	pEC50	=	9.7	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCn2cc(nn2)CCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL3358549	116216	0	None	-4	4	Mouse	9.7	pEC50	=	9.7	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCn2cc(nn2)CCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	1323	2669	55	None	-58	8	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00170
	92432	2669	55	None	-58	8	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00170
	CHEMBL430239	2669	55	None	-58	8	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00170
	118722937	116212	0	None	-5	4	Mouse	9.7	pEC50	=	9.7	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCc2cn(nn2)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL3358545	116212	0	None	-5	4	Mouse	9.7	pEC50	=	9.7	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCc2cn(nn2)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL2371851	210116	0	None	-5	4	Mouse	9.7	pEC50	=	9.7	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N1C(=O)[C@@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]1CC(=O)O	10.1021/jm0490843
	122194229	123957	0	None	-8	5	Mouse	9.7	pEC50	=	9.7	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells by AlphaScreen cAMP assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells by AlphaScreen cAMP assay	ChEMBL	1646	50	23	21	-4.1	CCCCC(NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2015.09.046
	CHEMBL3629347	123957	0	None	-8	5	Mouse	9.7	pEC50	=	9.7	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells by AlphaScreen cAMP assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells by AlphaScreen cAMP assay	ChEMBL	1646	50	23	21	-4.1	CCCCC(NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2015.09.046
	16132144	209256	36	None	-2	8	Mouse	9.7	pEC50	=	9.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acsmedchemlett.9b00198
	16133793	209256	36	None	-2	8	Mouse	9.7	pEC50	=	9.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acsmedchemlett.9b00198
	44273719	209256	36	None	-2	8	Mouse	9.7	pEC50	=	9.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acsmedchemlett.9b00198
	CHEMBL214332	209256	36	None	-2	8	Mouse	9.7	pEC50	=	9.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acsmedchemlett.9b00198
	168284733	191600	0	None	1	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2054	33	32	24	-4.1	CCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5195641	191600	0	None	1	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2054	33	32	24	-4.1	CCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	122194229	123957	0	None	-8	5	Mouse	9.6	pEC50	=	9.6	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assay	ChEMBL	1646	50	23	21	-4.1	CCCCC(NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2015.10.095
	CHEMBL3629347	123957	0	None	-8	5	Mouse	9.6	pEC50	=	9.6	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assay	ChEMBL	1646	50	23	21	-4.1	CCCCC(NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2015.10.095
	1324	301	25	None	-6	9	Mouse	9.6	pEC50	=	9.6	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm301253y
	16154396	301	25	None	-6	9	Mouse	9.6	pEC50	=	9.6	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm301253y
	16197727	301	25	None	-6	9	Mouse	9.6	pEC50	=	9.6	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm301253y
	44285019	301	25	None	-6	9	Mouse	9.6	pEC50	=	9.6	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm301253y
	57514683	301	25	None	-6	9	Mouse	9.6	pEC50	=	9.6	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm301253y
	91898441	301	25	None	-6	9	Mouse	9.6	pEC50	=	9.6	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm301253y
	CHEMBL441738	301	25	None	-6	9	Mouse	9.6	pEC50	=	9.6	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm301253y
	DB04931	301	25	None	-6	9	Mouse	9.6	pEC50	=	9.6	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm301253y
	CHEMBL405087	212518	0	None	-2	5	Rat	9.6	pEC50	=	9.6	Functional	Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R)	ChEMBL		None	None	None		C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O	10.1021/jm030452x
	CHEMBL414965	213143	0	None	-4	5	Rat	9.6	pEC50	=	9.6	Functional	Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R)	ChEMBL		None	None	None		C[C@@H](O)[C@H](NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O	10.1021/jm030452x
	1324	301	25	None	-6	9	Mouse	9.6	pEC50	=	9.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01894
	16154396	301	25	None	-6	9	Mouse	9.6	pEC50	=	9.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01894
	16197727	301	25	None	-6	9	Mouse	9.6	pEC50	=	9.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01894
	44285019	301	25	None	-6	9	Mouse	9.6	pEC50	=	9.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01894
	57514683	301	25	None	-6	9	Mouse	9.6	pEC50	=	9.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01894
	91898441	301	25	None	-6	9	Mouse	9.6	pEC50	=	9.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01894
	CHEMBL441738	301	25	None	-6	9	Mouse	9.6	pEC50	=	9.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01894
	DB04931	301	25	None	-6	9	Mouse	9.6	pEC50	=	9.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01894
	1324	301	25	None	-15	9	Human	9.6	pEC50	=	9.6	Functional	Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorEffective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm000211e
	16154396	301	25	None	-15	9	Human	9.6	pEC50	=	9.6	Functional	Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorEffective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm000211e
	16197727	301	25	None	-15	9	Human	9.6	pEC50	=	9.6	Functional	Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorEffective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm000211e
	44285019	301	25	None	-15	9	Human	9.6	pEC50	=	9.6	Functional	Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorEffective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm000211e
	57514683	301	25	None	-15	9	Human	9.6	pEC50	=	9.6	Functional	Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorEffective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm000211e
	91898441	301	25	None	-15	9	Human	9.6	pEC50	=	9.6	Functional	Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorEffective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm000211e
	CHEMBL441738	301	25	None	-15	9	Human	9.6	pEC50	=	9.6	Functional	Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorEffective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm000211e
	DB04931	301	25	None	-15	9	Human	9.6	pEC50	=	9.6	Functional	Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorEffective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm000211e
	1323	2669	55	None	-58	8	Human	9.6	pEC50	=	9.6	Functional	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm960845e
	92432	2669	55	None	-58	8	Human	9.6	pEC50	=	9.6	Functional	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm960845e
	CHEMBL430239	2669	55	None	-58	8	Human	9.6	pEC50	=	9.6	Functional	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm960845e
	CHEMBL267794	210710	0	None	-7	4	Mouse	9.6	pEC50	=	9.6	Functional	Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010061n
	168272660	190409	0	None	-2	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2202	33	32	24	-2.1	CCCC[C@@H]1NC(=O)[C@@H]2CSc3c(F)c(F)c(c(F)c3F)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5178164	190409	0	None	-2	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2202	33	32	24	-2.1	CCCC[C@@H]1NC(=O)[C@@H]2CSc3c(F)c(F)c(c(F)c3F)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	118722936	116211	0	None	-2	4	Mouse	9.5	pEC50	=	9.5	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCc2cn(nn2)CCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL3358544	116211	0	None	-2	4	Mouse	9.5	pEC50	=	9.5	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCc2cn(nn2)CCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	118722944	116219	0	None	-4	4	Mouse	9.5	pEC50	=	9.5	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1034	17	13	13	-1.1	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCn2cc(nn2)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL3358552	116219	0	None	-4	4	Mouse	9.5	pEC50	=	9.5	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1034	17	13	13	-1.1	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCn2cc(nn2)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL410763	212815	0	None	-7	4	Mouse	9.5	pEC50	=	9.5	Functional	Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010061n
	1324	301	25	None	-15	9	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at human MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	16154396	301	25	None	-15	9	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at human MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	16197727	301	25	None	-15	9	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at human MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	44285019	301	25	None	-15	9	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at human MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	57514683	301	25	None	-15	9	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at human MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	91898441	301	25	None	-15	9	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at human MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	CHEMBL441738	301	25	None	-15	9	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at human MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	DB04931	301	25	None	-15	9	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at human MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	168270124	189931	0	None	-2	4	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2096	33	32	24	-3.6	CCCC[C@@H]1NC(=O)[C@@H]2CSCCCSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5170533	189931	0	None	-2	4	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2096	33	32	24	-3.6	CCCC[C@@H]1NC(=O)[C@@H]2CSCCCSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	168276507	190241	0	None	-3	4	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2158	33	32	24	-2.3	CCCC[C@@H]1NC(=O)[C@@H]2CSCc3cccc(c3)CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5175487	190241	0	None	-3	4	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2158	33	32	24	-2.3	CCCC[C@@H]1NC(=O)[C@@H]2CSCc3cccc(c3)CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	1324	301	25	None	-6	9	Mouse	9.5	pEC50	=	9.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	16154396	301	25	None	-6	9	Mouse	9.5	pEC50	=	9.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	16197727	301	25	None	-6	9	Mouse	9.5	pEC50	=	9.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	44285019	301	25	None	-6	9	Mouse	9.5	pEC50	=	9.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	57514683	301	25	None	-6	9	Mouse	9.5	pEC50	=	9.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	91898441	301	25	None	-6	9	Mouse	9.5	pEC50	=	9.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	CHEMBL441738	301	25	None	-6	9	Mouse	9.5	pEC50	=	9.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	DB04931	301	25	None	-6	9	Mouse	9.5	pEC50	=	9.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00251
	1324	301	25	None	-6	9	Mouse	9.5	pEC50	=	9.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm800291b
	16154396	301	25	None	-6	9	Mouse	9.5	pEC50	=	9.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm800291b
	16197727	301	25	None	-6	9	Mouse	9.5	pEC50	=	9.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm800291b
	44285019	301	25	None	-6	9	Mouse	9.5	pEC50	=	9.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm800291b
	57514683	301	25	None	-6	9	Mouse	9.5	pEC50	=	9.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm800291b
	91898441	301	25	None	-6	9	Mouse	9.5	pEC50	=	9.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm800291b
	CHEMBL441738	301	25	None	-6	9	Mouse	9.5	pEC50	=	9.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm800291b
	DB04931	301	25	None	-6	9	Mouse	9.5	pEC50	=	9.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm800291b
	1324	301	25	None	-6	9	Mouse	9.5	pEC50	=	9.5	Functional	Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL		None	None	None		None	10.1021/jm500064t
	16154396	301	25	None	-6	9	Mouse	9.5	pEC50	=	9.5	Functional	Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL		None	None	None		None	10.1021/jm500064t
	16197727	301	25	None	-6	9	Mouse	9.5	pEC50	=	9.5	Functional	Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL		None	None	None		None	10.1021/jm500064t
	44285019	301	25	None	-6	9	Mouse	9.5	pEC50	=	9.5	Functional	Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL		None	None	None		None	10.1021/jm500064t
	57514683	301	25	None	-6	9	Mouse	9.5	pEC50	=	9.5	Functional	Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL		None	None	None		None	10.1021/jm500064t
	91898441	301	25	None	-6	9	Mouse	9.5	pEC50	=	9.5	Functional	Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL		None	None	None		None	10.1021/jm500064t
	CHEMBL441738	301	25	None	-6	9	Mouse	9.5	pEC50	=	9.5	Functional	Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL		None	None	None		None	10.1021/jm500064t
	DB04931	301	25	None	-6	9	Mouse	9.5	pEC50	=	9.5	Functional	Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL		None	None	None		None	10.1021/jm500064t
	16157270	212530	14	None	22	7	Human	9.5	pEC50	=	9.5	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm049579s
	CHEMBL405282	212530	14	None	22	7	Human	9.5	pEC50	=	9.5	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm049579s
	16157270	212530	14	None	22	7	Human	9.5	pEC50	=	9.5	Functional	Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorEffective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	CHEMBL405282	212530	14	None	22	7	Human	9.5	pEC50	=	9.5	Functional	Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorEffective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	168293710	192142	0	None	-3	4	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2158	33	32	24	-2.3	CCCC[C@@H]1NC(=O)[C@@H]2CSCc3ccc(cc3)CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5203986	192142	0	None	-3	4	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2158	33	32	24	-2.3	CCCC[C@@H]1NC(=O)[C@@H]2CSCc3ccc(cc3)CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	168289457	191356	0	None	-1	4	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2158	33	32	24	-2.3	CCCC[C@@H]1NC(=O)[C@@H]2CSCc3ccccc3CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5192329	191356	0	None	-1	4	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2158	33	32	24	-2.3	CCCC[C@@H]1NC(=O)[C@@H]2CSCc3ccccc3CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	1324	301	25	None	-6	9	Mouse	9.4	pEC50	=	9.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c02041
	16154396	301	25	None	-6	9	Mouse	9.4	pEC50	=	9.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c02041
	16197727	301	25	None	-6	9	Mouse	9.4	pEC50	=	9.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c02041
	44285019	301	25	None	-6	9	Mouse	9.4	pEC50	=	9.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c02041
	57514683	301	25	None	-6	9	Mouse	9.4	pEC50	=	9.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c02041
	91898441	301	25	None	-6	9	Mouse	9.4	pEC50	=	9.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c02041
	CHEMBL441738	301	25	None	-6	9	Mouse	9.4	pEC50	=	9.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c02041
	DB04931	301	25	None	-6	9	Mouse	9.4	pEC50	=	9.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c02041
	CHEMBL413912	213077	0	None	-5	3	Human	9.4	pEC50	=	9.4	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2004.07.046
	1324	301	25	None	-15	9	Human	9.4	pEC50	=	9.4	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00552-3
	16154396	301	25	None	-15	9	Human	9.4	pEC50	=	9.4	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00552-3
	16197727	301	25	None	-15	9	Human	9.4	pEC50	=	9.4	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00552-3
	44285019	301	25	None	-15	9	Human	9.4	pEC50	=	9.4	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00552-3
	57514683	301	25	None	-15	9	Human	9.4	pEC50	=	9.4	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00552-3
	91898441	301	25	None	-15	9	Human	9.4	pEC50	=	9.4	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00552-3
	CHEMBL441738	301	25	None	-15	9	Human	9.4	pEC50	=	9.4	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00552-3
	DB04931	301	25	None	-15	9	Human	9.4	pEC50	=	9.4	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00552-3
	CHEMBL264536	210604	5	None	-8	4	Mouse	9.4	pEC50	=	9.4	Functional	Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1021/jm010061n
	168281389	190898	0	None	-1	4	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2149	33	33	26	-5.2	CCCC[C@@H]1NC(=O)[C@@H]2CSC3=C(SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2)C(=O)NC3=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5185405	190898	0	None	-1	4	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2149	33	33	26	-5.2	CCCC[C@@H]1NC(=O)[C@@H]2CSC3=C(SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2)C(=O)NC3=O	10.1021/acs.jmedchem.2c00793
	44415913	79922	0	None	-5	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	736	16	6	7	0.8	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL212614	79922	0	None	-5	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	736	16	6	7	0.8	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	16132144	209256	36	None	-2	8	Mouse	9.4	pEC50	=	9.4	Functional	Agonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayAgonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acsmedchemlett.5b00053
	16133793	209256	36	None	-2	8	Mouse	9.4	pEC50	=	9.4	Functional	Agonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayAgonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acsmedchemlett.5b00053
	44273719	209256	36	None	-2	8	Mouse	9.4	pEC50	=	9.4	Functional	Agonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayAgonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acsmedchemlett.5b00053
	CHEMBL214332	209256	36	None	-2	8	Mouse	9.4	pEC50	=	9.4	Functional	Agonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayAgonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acsmedchemlett.5b00053
	1324	301	25	None	-6	9	Mouse	9.4	pEC50	=	9.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00053
	16154396	301	25	None	-6	9	Mouse	9.4	pEC50	=	9.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00053
	16197727	301	25	None	-6	9	Mouse	9.4	pEC50	=	9.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00053
	44285019	301	25	None	-6	9	Mouse	9.4	pEC50	=	9.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00053
	57514683	301	25	None	-6	9	Mouse	9.4	pEC50	=	9.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00053
	91898441	301	25	None	-6	9	Mouse	9.4	pEC50	=	9.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00053
	CHEMBL441738	301	25	None	-6	9	Mouse	9.4	pEC50	=	9.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00053
	DB04931	301	25	None	-6	9	Mouse	9.4	pEC50	=	9.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00053
	118722933	116209	0	None	-8	4	Mouse	9.4	pEC50	=	9.4	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1038	33	13	11	1.2	CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O	10.1021/jm501027w
	CHEMBL3358541	116209	0	None	-8	4	Mouse	9.4	pEC50	=	9.4	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1038	33	13	11	1.2	CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O	10.1021/jm501027w
	44416057	81162	0	None	-1	3	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	745	17	6	7	0.2	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H](CCC(N)=O)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL215833	81162	0	None	-1	3	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	745	17	6	7	0.2	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H](CCC(N)=O)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	16132144	209256	36	None	-2	8	Mouse	9.3	pEC50	=	9.3	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells by AlphaScreen cAMP assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells by AlphaScreen cAMP assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2015.09.046
	16133793	209256	36	None	-2	8	Mouse	9.3	pEC50	=	9.3	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells by AlphaScreen cAMP assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells by AlphaScreen cAMP assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2015.09.046
	44273719	209256	36	None	-2	8	Mouse	9.3	pEC50	=	9.3	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells by AlphaScreen cAMP assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells by AlphaScreen cAMP assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2015.09.046
	CHEMBL214332	209256	36	None	-2	8	Mouse	9.3	pEC50	=	9.3	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells by AlphaScreen cAMP assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells by AlphaScreen cAMP assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2015.09.046
	16132144	209256	36	None	-2	8	Mouse	9.3	pEC50	=	9.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0492756
	16133793	209256	36	None	-2	8	Mouse	9.3	pEC50	=	9.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0492756
	44273719	209256	36	None	-2	8	Mouse	9.3	pEC50	=	9.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0492756
	CHEMBL214332	209256	36	None	-2	8	Mouse	9.3	pEC50	=	9.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0492756
	16132144	209256	36	None	-2	8	Mouse	9.3	pEC50	=	9.3	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0490843
	16133793	209256	36	None	-2	8	Mouse	9.3	pEC50	=	9.3	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0490843
	44273719	209256	36	None	-2	8	Mouse	9.3	pEC50	=	9.3	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0490843
	CHEMBL214332	209256	36	None	-2	8	Mouse	9.3	pEC50	=	9.3	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0490843
	101670969	168872	23	None	1	4	Mouse	9.3	pEC50	=	9.3	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	1623	49	22	22	-4.3	CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C(C)C	10.1021/acs.jmedchem.0c02041
	16131138	168872	23	None	1	4	Mouse	9.3	pEC50	=	9.3	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	1623	49	22	22	-4.3	CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C(C)C	10.1021/acs.jmedchem.0c02041
	44349184	168872	23	None	1	4	Mouse	9.3	pEC50	=	9.3	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	1623	49	22	22	-4.3	CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C(C)C	10.1021/acs.jmedchem.0c02041
	53310908	168872	23	None	1	4	Mouse	9.3	pEC50	=	9.3	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	1623	49	22	22	-4.3	CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C(C)C	10.1021/acs.jmedchem.0c02041
	91898438	168872	23	None	1	4	Mouse	9.3	pEC50	=	9.3	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	1623	49	22	22	-4.3	CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C(C)C	10.1021/acs.jmedchem.0c02041
	CHEMBL438402	168872	23	None	1	4	Mouse	9.3	pEC50	=	9.3	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	1623	49	22	22	-4.3	CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C(C)C	10.1021/acs.jmedchem.0c02041
	118722942	116217	0	None	-4	4	Mouse	9.2	pEC50	=	9.2	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cn2cc(nn2)CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL3358550	116217	0	None	-4	4	Mouse	9.2	pEC50	=	9.2	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cn2cc(nn2)CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	168295726	192381	0	None	-6	4	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2547	50	34	33	-2.8	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCOCCOCCC(=O)O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5207936	192381	0	None	-6	4	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2547	50	34	33	-2.8	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCOCCOCCC(=O)O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	118722943	116218	0	None	-4	4	Mouse	9.2	pEC50	=	9.2	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1034	17	13	13	-1.1	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCc2cn(nn2)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL3358551	116218	0	None	-4	4	Mouse	9.2	pEC50	=	9.2	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1034	17	13	13	-1.1	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCc2cn(nn2)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	16132144	209256	36	None	-7	8	Human	9.2	pEC50	=	9.2	Functional	Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm00018a005
	16133793	209256	36	None	-7	8	Human	9.2	pEC50	=	9.2	Functional	Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm00018a005
	44273719	209256	36	None	-7	8	Human	9.2	pEC50	=	9.2	Functional	Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm00018a005
	CHEMBL214332	209256	36	None	-7	8	Human	9.2	pEC50	=	9.2	Functional	Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm00018a005
	10408	717	28	None	-5	4	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.2c00793
	5329	717	28	None	-5	4	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.2c00793
	9941379	717	28	None	-5	4	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.2c00793
	CHEMBL2070241	717	28	None	-5	4	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.2c00793
	DB11653	717	28	None	-5	4	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.2c00793
	10408	717	28	None	-5	4	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.1c00095
	5329	717	28	None	-5	4	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.1c00095
	9941379	717	28	None	-5	4	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.1c00095
	CHEMBL2070241	717	28	None	-5	4	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.1c00095
	DB11653	717	28	None	-5	4	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.1c00095
	CHEMBL408257	212681	0	None	-2	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human Melanocortin-3 receptor as peptide required for 50% maximal cAMP releaseAgonist activity at human Melanocortin-3 receptor as peptide required for 50% maximal cAMP release	ChEMBL		None	None	None		CC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H]1CSSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](CCC(=O)O)NC1=O	10.1021/jm0501432
	168283616	191215	0	None	-1	4	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2110	33	32	25	-4.5	CCCC[C@@H]1NC(=O)[C@@H]2CSCC(=O)CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5190042	191215	0	None	-1	4	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2110	33	32	25	-4.5	CCCC[C@@H]1NC(=O)[C@@H]2CSCC(=O)CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	42630327	155847	0	None	-2	4	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1119	32	19	14	-3.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CS)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CS)C(N)=O	10.1021/acs.jmedchem.8b00170
	CHEMBL4060381	155847	0	None	-2	4	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1119	32	19	14	-3.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CS)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CS)C(N)=O	10.1021/acs.jmedchem.8b00170
	16132144	209256	36	None	-2	8	Mouse	9.1	pEC50	=	9.1	Functional	Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm010061n
	16133793	209256	36	None	-2	8	Mouse	9.1	pEC50	=	9.1	Functional	Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm010061n
	44273719	209256	36	None	-2	8	Mouse	9.1	pEC50	=	9.1	Functional	Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm010061n
	CHEMBL214332	209256	36	None	-2	8	Mouse	9.1	pEC50	=	9.1	Functional	Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm010061n
	16132144	209256	36	None	-2	8	Mouse	9.1	pEC50	=	9.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acs.jmedchem.5b01894
	16133793	209256	36	None	-2	8	Mouse	9.1	pEC50	=	9.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acs.jmedchem.5b01894
	44273719	209256	36	None	-2	8	Mouse	9.1	pEC50	=	9.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acs.jmedchem.5b01894
	CHEMBL214332	209256	36	None	-2	8	Mouse	9.1	pEC50	=	9.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acs.jmedchem.5b01894
	16132144	209256	36	None	-2	8	Mouse	9.1	pEC50	=	9.1	Functional	Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm010524p
	16133793	209256	36	None	-2	8	Mouse	9.1	pEC50	=	9.1	Functional	Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm010524p
	44273719	209256	36	None	-2	8	Mouse	9.1	pEC50	=	9.1	Functional	Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm010524p
	CHEMBL214332	209256	36	None	-2	8	Mouse	9.1	pEC50	=	9.1	Functional	Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm010524p
	16132144	209256	36	None	-2	8	Mouse	9.1	pEC50	=	9.1	Functional	Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0303608
	16133793	209256	36	None	-2	8	Mouse	9.1	pEC50	=	9.1	Functional	Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0303608
	44273719	209256	36	None	-2	8	Mouse	9.1	pEC50	=	9.1	Functional	Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0303608
	CHEMBL214332	209256	36	None	-2	8	Mouse	9.1	pEC50	=	9.1	Functional	Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0303608
	16132144	209256	36	None	-2	8	Mouse	9.1	pEC50	=	9.1	Functional	Agonistic activity evaluated at melanocortin 3 receptor (MC3R) of mouse HEK293 cellsAgonistic activity evaluated at melanocortin 3 receptor (MC3R) of mouse HEK293 cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2003.08.078
	16133793	209256	36	None	-2	8	Mouse	9.1	pEC50	=	9.1	Functional	Agonistic activity evaluated at melanocortin 3 receptor (MC3R) of mouse HEK293 cellsAgonistic activity evaluated at melanocortin 3 receptor (MC3R) of mouse HEK293 cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2003.08.078
	44273719	209256	36	None	-2	8	Mouse	9.1	pEC50	=	9.1	Functional	Agonistic activity evaluated at melanocortin 3 receptor (MC3R) of mouse HEK293 cellsAgonistic activity evaluated at melanocortin 3 receptor (MC3R) of mouse HEK293 cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2003.08.078
	CHEMBL214332	209256	36	None	-2	8	Mouse	9.1	pEC50	=	9.1	Functional	Agonistic activity evaluated at melanocortin 3 receptor (MC3R) of mouse HEK293 cellsAgonistic activity evaluated at melanocortin 3 receptor (MC3R) of mouse HEK293 cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2003.08.078
	1324	301	25	None	-15	9	Human	9.1	pEC50	=	9.1	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	16154396	301	25	None	-15	9	Human	9.1	pEC50	=	9.1	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	16197727	301	25	None	-15	9	Human	9.1	pEC50	=	9.1	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	44285019	301	25	None	-15	9	Human	9.1	pEC50	=	9.1	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	57514683	301	25	None	-15	9	Human	9.1	pEC50	=	9.1	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	91898441	301	25	None	-15	9	Human	9.1	pEC50	=	9.1	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	CHEMBL441738	301	25	None	-15	9	Human	9.1	pEC50	=	9.1	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	DB04931	301	25	None	-15	9	Human	9.1	pEC50	=	9.1	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	1324	301	25	None	-15	9	Human	9.1	pEC50	=	9.1	Functional	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL		None	None	None		None	10.1021/jm030111j
	16154396	301	25	None	-15	9	Human	9.1	pEC50	=	9.1	Functional	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL		None	None	None		None	10.1021/jm030111j
	16197727	301	25	None	-15	9	Human	9.1	pEC50	=	9.1	Functional	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL		None	None	None		None	10.1021/jm030111j
	44285019	301	25	None	-15	9	Human	9.1	pEC50	=	9.1	Functional	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL		None	None	None		None	10.1021/jm030111j
	57514683	301	25	None	-15	9	Human	9.1	pEC50	=	9.1	Functional	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL		None	None	None		None	10.1021/jm030111j
	91898441	301	25	None	-15	9	Human	9.1	pEC50	=	9.1	Functional	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL		None	None	None		None	10.1021/jm030111j
	CHEMBL441738	301	25	None	-15	9	Human	9.1	pEC50	=	9.1	Functional	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL		None	None	None		None	10.1021/jm030111j
	DB04931	301	25	None	-15	9	Human	9.1	pEC50	=	9.1	Functional	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL		None	None	None		None	10.1021/jm030111j
	1324	301	25	None	-6	9	Mouse	9.1	pEC50	=	9.1	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm501027w
	16154396	301	25	None	-6	9	Mouse	9.1	pEC50	=	9.1	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm501027w
	16197727	301	25	None	-6	9	Mouse	9.1	pEC50	=	9.1	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm501027w
	44285019	301	25	None	-6	9	Mouse	9.1	pEC50	=	9.1	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm501027w
	57514683	301	25	None	-6	9	Mouse	9.1	pEC50	=	9.1	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm501027w
	91898441	301	25	None	-6	9	Mouse	9.1	pEC50	=	9.1	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm501027w
	CHEMBL441738	301	25	None	-6	9	Mouse	9.1	pEC50	=	9.1	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm501027w
	DB04931	301	25	None	-6	9	Mouse	9.1	pEC50	=	9.1	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/jm501027w
	118722930	116207	0	None	-10	4	Mouse	9.1	pEC50	=	9.1	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1052	34	13	11	1.6	CCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O	10.1021/jm501027w
	CHEMBL3358539	116207	0	None	-10	4	Mouse	9.1	pEC50	=	9.1	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1052	34	13	11	1.6	CCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O	10.1021/jm501027w
	118722926	116204	0	None	-7	4	Mouse	9.0	pEC50	=	9.0	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1052	34	13	11	1.6	CCCCC[C@H](NC(=O)[C@H](CCCC)NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCN=[N+]=[N-])C(N)=O	10.1021/jm501027w
	CHEMBL3358535	116204	0	None	-7	4	Mouse	9.0	pEC50	=	9.0	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1052	34	13	11	1.6	CCCCC[C@H](NC(=O)[C@H](CCCC)NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCN=[N+]=[N-])C(N)=O	10.1021/jm501027w
	168271237	190464	0	None	-3	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2788	45	36	36	0.1	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCNC(=O)c3ccc4c(c3)C(=O)OC43c4ccc(O)cc4Oc4cc(O)ccc43)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5179081	190464	0	None	-3	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2788	45	36	36	0.1	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCNC(=O)c3ccc4c(c3)C(=O)OC43c4ccc(O)cc4Oc4cc(O)ccc43)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL2369484	209604	0	None	-4	4	Mouse	9.0	pEC50	=	9	Functional	Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NN[C@H]2Cc3ccc(O)cc3NC2=O)CC(=O)N[C@H](C(=O)NN[C@@H](Cc2ccc(O)cc2)C(=O)C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm0303608
	44415914	139245	0	None	-5	3	Human	9.0	pEC50	=	9	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	762	16	6	7	1.8	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL379054	139245	0	None	-5	3	Human	9.0	pEC50	=	9	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	762	16	6	7	1.8	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	145966364	164096	0	None	3	3	Human	9.0	pEC50	=	9	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	865	11	12	9	-0.7	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4209913	164096	0	None	3	3	Human	9.0	pEC50	=	9	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	865	11	12	9	-0.7	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL2372859	210277	1	None	-5	3	Mouse	9.0	pEC50	=	9.0	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm501027w
	16132144	209256	36	None	-7	8	Human	9.0	pEC50	=	9.0	Functional	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 3 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2005.02.068
	16133793	209256	36	None	-7	8	Human	9.0	pEC50	=	9.0	Functional	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 3 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2005.02.068
	44273719	209256	36	None	-7	8	Human	9.0	pEC50	=	9.0	Functional	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 3 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2005.02.068
	CHEMBL214332	209256	36	None	-7	8	Human	9.0	pEC50	=	9.0	Functional	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 3 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2005.02.068
	16132144	209256	36	None	-7	8	Human	9.0	pEC50	=	9.0	Functional	Effective concentration towards human melanocortin-3 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-3 receptor mediated cAMP accumulation in CHO cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2004.10.020
	16133793	209256	36	None	-7	8	Human	9.0	pEC50	=	9.0	Functional	Effective concentration towards human melanocortin-3 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-3 receptor mediated cAMP accumulation in CHO cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2004.10.020
	44273719	209256	36	None	-7	8	Human	9.0	pEC50	=	9.0	Functional	Effective concentration towards human melanocortin-3 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-3 receptor mediated cAMP accumulation in CHO cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2004.10.020
	CHEMBL214332	209256	36	None	-7	8	Human	9.0	pEC50	=	9.0	Functional	Effective concentration towards human melanocortin-3 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-3 receptor mediated cAMP accumulation in CHO cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2004.10.020
	16132144	209256	36	None	-7	8	Human	9.0	pEC50	=	9.0	Functional	Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 3 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 3 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2005.05.109
	16133793	209256	36	None	-7	8	Human	9.0	pEC50	=	9.0	Functional	Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 3 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 3 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2005.05.109
	44273719	209256	36	None	-7	8	Human	9.0	pEC50	=	9.0	Functional	Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 3 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 3 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2005.05.109
	CHEMBL214332	209256	36	None	-7	8	Human	9.0	pEC50	=	9.0	Functional	Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 3 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)Inhibition concentration (binding affinity) exhibited against human melanocortin receptor 3 by radio labeled ligand assay (Displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2005.05.109
	CHEMBL428801	213449	0	None	-26	5	Human	9.0	pEC50	=	9.0	Functional	Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(I)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm00018a005
	CHEMBL5090946	215262	0	None	-12	4	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](C)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL263822	210567	0	None	5	4	Human	8.9	pEC50	=	8.9	Functional	Activity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulation	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCCN=C(N)N)NC1=O	10.1021/jm0510326
	CHEMBL5087859	215100	0	None	4	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	11845450	138444	0	None	-28	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	652	15	5	6	2.6	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL377465	138444	0	None	-28	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	652	15	5	6	2.6	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	118722931	116208	0	None	-10	4	Mouse	8.9	pEC50	=	8.9	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1052	34	13	11	1.6	CCCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O	10.1021/jm501027w
	CHEMBL3358540	116208	0	None	-10	4	Mouse	8.9	pEC50	=	8.9	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1052	34	13	11	1.6	CCCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O	10.1021/jm501027w
	16132144	209256	36	None	-7	8	Human	8.9	pEC50	=	8.9	Functional	In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 3 receptor (hMC3R)In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/s0960-894x(03)00796-0
	16133793	209256	36	None	-7	8	Human	8.9	pEC50	=	8.9	Functional	In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 3 receptor (hMC3R)In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/s0960-894x(03)00796-0
	44273719	209256	36	None	-7	8	Human	8.9	pEC50	=	8.9	Functional	In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 3 receptor (hMC3R)In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/s0960-894x(03)00796-0
	CHEMBL214332	209256	36	None	-7	8	Human	8.9	pEC50	=	8.9	Functional	In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 3 receptor (hMC3R)In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/s0960-894x(03)00796-0
	CHEMBL5083551	214846	0	None	-25	4	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](C)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL3600920	211800	0	None	2	4	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	1323	2669	55	None	-58	8	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00488
	92432	2669	55	None	-58	8	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00488
	CHEMBL430239	2669	55	None	-58	8	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00488
	118722927	116205	0	None	-8	4	Mouse	8.8	pEC50	=	8.8	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1052	34	13	11	1.6	CCCCCC[C@H](NC(=O)[C@H](CCCC)NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CN=[N+]=[N-])C(N)=O	10.1021/jm501027w
	CHEMBL3358536	116205	0	None	-8	4	Mouse	8.8	pEC50	=	8.8	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1052	34	13	11	1.6	CCCCCC[C@H](NC(=O)[C@H](CCCC)NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CN=[N+]=[N-])C(N)=O	10.1021/jm501027w
	CHEMBL439691	213825	0	None	5	3	Human	8.8	pEC50	=	8.8	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON	10.1021/jm049579s
	CHEMBL438030	213721	0	None	21	3	Human	8.8	pEC50	=	8.8	Functional	Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm030119t
	CHEMBL267900	210714	0	None	-5	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human Melanocortin-3 receptor as peptide required for 50% maximal cAMP releaseAgonist activity at human Melanocortin-3 receptor as peptide required for 50% maximal cAMP release	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CSSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](CCC(=O)O)NC1=O	10.1021/jm0501432
	CHEMBL1688107	208811	0	None	-8	4	Mouse	8.8	pEC50	=	8.8	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	145971389	164609	0	None	2	4	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	851	11	12	9	-1.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4216242	164609	0	None	2	4	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	851	11	12	9	-1.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	1323	2669	55	None	-58	8	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMXAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMX	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01285
	92432	2669	55	None	-58	8	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMXAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMX	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01285
	CHEMBL430239	2669	55	None	-58	8	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMXAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMX	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01285
	1323	2669	55	None	-58	8	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1021/jm070461w
	92432	2669	55	None	-58	8	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1021/jm070461w
	CHEMBL430239	2669	55	None	-58	8	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1021/jm070461w
	CHEMBL393075	212439	0	None	-6	4	Human	8.7	pEC50	=	8.7	Functional	Effect on human MC3R expressed in HEK293 cells assessed as intracellular cAMP accumulationEffect on human MC3R expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL		None	None	None		CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1016/j.bmcl.2007.02.020
	1323	2669	55	None	-58	8	Human	8.7	pEC50	=	8.7	Functional	Activity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1021/jm0510326
	92432	2669	55	None	-58	8	Human	8.7	pEC50	=	8.7	Functional	Activity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1021/jm0510326
	CHEMBL430239	2669	55	None	-58	8	Human	8.7	pEC50	=	8.7	Functional	Activity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1021/jm0510326
	1323	2669	55	None	-58	8	Human	8.7	pEC50	=	8.7	Functional	Activity at hMC3R transfected in HEK293 cells assessed as intracellular cAMP accumulationActivity at hMC3R transfected in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1021/jm060768f
	92432	2669	55	None	-58	8	Human	8.7	pEC50	=	8.7	Functional	Activity at hMC3R transfected in HEK293 cells assessed as intracellular cAMP accumulationActivity at hMC3R transfected in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1021/jm060768f
	CHEMBL430239	2669	55	None	-58	8	Human	8.7	pEC50	=	8.7	Functional	Activity at hMC3R transfected in HEK293 cells assessed as intracellular cAMP accumulationActivity at hMC3R transfected in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1021/jm060768f
	145973975	164633	0	None	11	4	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	901	11	12	9	0.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4216654	164633	0	None	11	4	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	901	11	12	9	0.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	1323	2669	55	None	-58	8	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level	ChEMBL		None	None	None		None	10.1021/jm801300c
	92432	2669	55	None	-58	8	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level	ChEMBL		None	None	None		None	10.1021/jm801300c
	CHEMBL430239	2669	55	None	-58	8	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level	ChEMBL		None	None	None		None	10.1021/jm801300c
	CHEMBL3752534	212193	1	None	25	4	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMXAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMX	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C1=O	10.1021/acs.jmedchem.5b01285
	118722940	116215	0	None	-2	4	Mouse	8.7	pEC50	=	8.7	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCn2cc(nn2)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL3358548	116215	0	None	-2	4	Mouse	8.7	pEC50	=	8.7	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCn2cc(nn2)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL3358537	211545	0	None	-7	4	Mouse	8.7	pEC50	=	8.7	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C#CC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCCN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O	10.1021/jm501027w
	44416106	141421	0	None	-19	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	617	12	4	5	1.5	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL384176	141421	0	None	-19	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	617	12	4	5	1.5	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	44413830	77921	0	None	-2	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	587	14	5	6	1.3	NC(=O)C[C@H](N)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL209622	77921	0	None	-2	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	587	14	5	6	1.3	NC(=O)C[C@H](N)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	155549760	173853	0	None	-25	4	Mouse	8.0	pEC50	=	8	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	711	17	10	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4539621	173853	0	None	-25	4	Mouse	8.0	pEC50	=	8	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	711	17	10	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	127047475	139724	0	None	-60	5	Mouse	8.0	pEC50	=	8	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	1630	54	21	19	-1.2	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	132991507	139724	0	None	-60	5	Mouse	8.0	pEC50	=	8	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	1630	54	21	19	-1.2	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL3798421	139724	0	None	-60	5	Mouse	8.0	pEC50	=	8	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	1630	54	21	19	-1.2	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	16132144	209256	36	None	-2	8	Mouse	8.0	pEC50	=	8.0	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2009.07.025
	16133793	209256	36	None	-2	8	Mouse	8.0	pEC50	=	8.0	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2009.07.025
	44273719	209256	36	None	-2	8	Mouse	8.0	pEC50	=	8.0	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2009.07.025
	CHEMBL214332	209256	36	None	-2	8	Mouse	8.0	pEC50	=	8.0	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2009.07.025
	24774358	154880	0	None	1	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL	811	9	10	8	-0.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)/C=C\C(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL400866	154880	0	None	1	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL	811	9	10	8	-0.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)/C=C\C(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	155565321	175552	0	None	-3	4	Mouse	7.0	pEC50	=	7	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	718	13	5	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4579448	175552	0	None	-3	4	Mouse	7.0	pEC50	=	7	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	718	13	5	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	155567399	175942	0	None	-21	4	Mouse	7.0	pEC50	=	7	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	769	19	9	7	-0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4588429	175942	0	None	-21	4	Mouse	7.0	pEC50	=	7	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	769	19	9	7	-0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL320157	211203	0	None	-1	4	Mouse	7.0	pEC50	=	7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		CC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.9b00198
	137638725	156955	0	None	-38	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1728	21	21	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4073016	156955	0	None	-38	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1728	21	21	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	137660671	159194	0	None	-1071	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1708	20	19	21	-2.8	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4098785	159194	0	None	-1071	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1708	20	19	21	-2.8	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL411359	212856	0	None	-4	4	Human	6.0	pEC50	=	6	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm049579s
	155566074	175710	0	None	-33	3	Mouse	5.0	pEC50	=	5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	722	15	8	7	-1.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4582914	175710	0	None	-33	3	Mouse	5.0	pEC50	=	5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	722	15	8	7	-1.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	44305763	203063	0	None	-5	4	Mouse	4.0	pEC50	=	4	Functional	Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cellsAgonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells	ChEMBL	490	11	5	4	3.1	NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NN1CCC(Cc2ccccc2)CC1	10.1016/s0960-894x(03)00318-4
	CHEMBL63850	203063	0	None	-5	4	Mouse	4.0	pEC50	=	4	Functional	Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cellsAgonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells	ChEMBL	490	11	5	4	3.1	NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NN1CCC(Cc2ccccc2)CC1	10.1016/s0960-894x(03)00318-4
	44305704	203314	0	None	-4	4	Mouse	4.0	pEC50	=	4	Functional	Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cellsAgonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells	ChEMBL	407	10	5	3	2.4	NCCCCNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1	10.1016/s0960-894x(03)00318-4
	CHEMBL64954	203314	0	None	-4	4	Mouse	4.0	pEC50	=	4	Functional	Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cellsAgonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells	ChEMBL	407	10	5	3	2.4	NCCCCNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1	10.1016/s0960-894x(03)00318-4
	44441645	94098	0	None	-93	3	Human	6.0	pEC50	=	6	Functional	Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production	ChEMBL	605	12	2	7	4.4	CCCCCCC1(Cc2nnnn2C)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL249277	94098	0	None	-93	3	Human	6.0	pEC50	=	6	Functional	Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production	ChEMBL	605	12	2	7	4.4	CCCCCCC1(Cc2nnnn2C)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	44394660	67024	0	None	-70	3	Human	6.0	pEC50	=	6.0	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	772	20	9	7	0.2	NC(=O)CC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL187167	67024	0	None	-70	3	Human	6.0	pEC50	=	6.0	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	772	20	9	7	0.2	NC(=O)CC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	44394654	123947	0	None	-26	3	Human	6.0	pEC50	=	6.0	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	775	20	8	7	1.7	CSCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL362879	123947	0	None	-26	3	Human	6.0	pEC50	=	6.0	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	775	20	8	7	1.7	CSCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	11787684	70245	0	None	-36	4	Mouse	7.0	pEC50	=	7.0	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL	811	27	9	7	2.9	CCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL194217	70245	0	None	-36	4	Mouse	7.0	pEC50	=	7.0	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL	811	27	9	7	2.9	CCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	25132866	172587	0	None	-20	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	623	11	2	5	3.9	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)c1ccncc1	10.1021/jm800525p
	CHEMBL449131	172587	0	None	-20	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	623	11	2	5	3.9	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)c1ccncc1	10.1021/jm800525p
	CHEMBL2323791	209494	0	None	-9	4	Mouse	5.0	pEC50	=	5.0	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	155556047	174473	0	None	-3	4	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	683	16	8	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4554828	174473	0	None	-3	4	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	683	16	8	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4299612	213571	0	None	-3	4	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		CC(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@@H]1C(=O)NCC(=O)N1CCC[C@@H]1C(=O)NCC(=O)N1CCC[C@@H]1C(=O)NCC(=O)N1CCC[C@@H]1C(=O)NCC(=O)N1CCC[C@@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(N)=O	10.1021/acs.jmedchem.5b01894
	46885761	7996	0	None	-173	4	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	506	3	1	3	5.1	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)cc1F	10.1021/jm9017866
	CHEMBL1090813	7996	0	None	-173	4	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	506	3	1	3	5.1	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)cc1F	10.1021/jm9017866
	71457994	78550	0	None	-26	4	Mouse	5.0	pEC50	=	5.0	Functional	Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cellsAgonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells	ChEMBL	441	8	5	3	3.7	NCc1ccc(NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)NCc2ccccc2)cc1	10.1016/s0960-894x(03)00318-4
	CHEMBL2112213	78550	0	None	-26	4	Mouse	5.0	pEC50	=	5.0	Functional	Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cellsAgonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells	ChEMBL	441	8	5	3	3.7	NCc1ccc(NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)NCc2ccccc2)cc1	10.1016/s0960-894x(03)00318-4
	25133556	188825	0	None	-83	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	629	11	3	5	3.2	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1CCNCC1	10.1021/jm800525p
	CHEMBL506762	188825	0	None	-83	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	629	11	3	5	3.2	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1CCNCC1	10.1021/jm800525p
	122184635	122408	0	None	-2	4	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600916	122408	0	None	-2	4	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	162673830	183135	0	None	-47	3	Mouse	8.0	pEC50	=	8.0	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	753	18	10	7	0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	CHEMBL4795352	183135	0	None	-47	3	Mouse	8.0	pEC50	=	8.0	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	753	18	10	7	0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	CHEMBL2371712	210086	0	None	-2	4	Human	8.0	pEC50	=	8.0	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON	10.1021/jm049579s
	CHEMBL3349030	211382	0	None	1	3	Human	8.0	pEC50	=	8.0	Functional	Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorEffective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	CHEMBL5091236	215276	0	None	-102	4	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	90643803	111716	0	None	-26	5	Mouse	7.9	pEC50	=	7.9	Functional	Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL	898	18	9	7	0.4	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O	10.1021/jm500064t
	CHEMBL3287323	111716	0	None	-26	5	Mouse	7.9	pEC50	=	7.9	Functional	Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL	898	18	9	7	0.4	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O	10.1021/jm500064t
	155556954	174524	0	None	-363	4	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	692	15	8	7	0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4556149	174524	0	None	-363	4	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	692	15	8	7	0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	162662213	181472	0	None	-2	3	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	706	15	6	7	1.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	CHEMBL4764827	181472	0	None	-2	3	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	706	15	6	7	1.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	162661724	181511	0	None	-3	3	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	668	14	5	6	1.7	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C	10.1021/acsmedchemlett.0c00561
	CHEMBL4765199	181511	0	None	-3	3	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	668	14	5	6	1.7	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C	10.1021/acsmedchemlett.0c00561
	25128751	173560	0	None	-29	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	629	11	2	6	4.0	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)c1cscn1	10.1021/jm800525p
	CHEMBL453300	173560	0	None	-29	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	629	11	2	6	4.0	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)c1cscn1	10.1021/jm800525p
	137642664	158056	0	None	-12	3	Mouse	6.0	pEC50	=	6.0	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	772	18	9	7	-0.3	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4086346	158056	0	None	-12	3	Mouse	6.0	pEC50	=	6.0	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	772	18	9	7	-0.3	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	155551195	173918	0	None	-52	4	Mouse	6.0	pEC50	=	6.0	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	626	13	5	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4541098	173918	0	None	-52	4	Mouse	6.0	pEC50	=	6.0	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	626	13	5	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	71459938	78952	0	None	-19	4	Human	6.0	pEC50	=	6.0	Functional	Effective concentration against human melanocortin 3 receptor in cAMP release assayEffective concentration against human melanocortin 3 receptor in cAMP release assay	ChEMBL	622	9	2	6	6.6	COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@H]3CCNC[C@@H]3c3ccc(F)cc3)C2=O)cc1	10.1016/j.bmcl.2005.06.033
	CHEMBL2113043	78952	0	None	-19	4	Human	6.0	pEC50	=	6.0	Functional	Effective concentration against human melanocortin 3 receptor in cAMP release assayEffective concentration against human melanocortin 3 receptor in cAMP release assay	ChEMBL	622	9	2	6	6.6	COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@H]3CCNC[C@@H]3c3ccc(F)cc3)C2=O)cc1	10.1016/j.bmcl.2005.06.033
	25128749	178446	0	None	-37	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	560	10	2	4	3.2	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(C)=O	10.1021/jm800525p
	CHEMBL466380	178446	0	None	-37	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	560	10	2	4	3.2	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(C)=O	10.1021/jm800525p
	CHEMBL3601426	211803	0	None	-24	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	11847001	80199	0	None	-125	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	652	15	5	6	2.6	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL213747	80199	0	None	-125	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	652	15	5	6	2.6	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N	10.1021/jm060384p
	44441641	94272	0	None	-69	3	Human	6.9	pEC50	=	6.9	Functional	Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production	ChEMBL	603	8	2	7	4.0	Cn1nnnc1CC1(C2CCCCC2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL250508	94272	0	None	-69	3	Human	6.9	pEC50	=	6.9	Functional	Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production	ChEMBL	603	8	2	7	4.0	Cn1nnnc1CC1(C2CCCCC2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	145989222	167256	0	None	-6	4	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assayAgonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assay	ChEMBL	676	17	7	6	2.2	CCCC[C@H](NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	CHEMBL4293365	167256	0	None	-6	4	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assayAgonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assay	ChEMBL	676	17	7	6	2.2	CCCC[C@H](NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	11328898	7928	22	None	-95	4	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	470	3	1	3	4.8	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1	10.1021/jm9017866
	CHEMBL1090488	7928	22	None	-95	4	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	470	3	1	3	4.8	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1	10.1021/jm9017866
	CHEMBL1204059	7928	22	None	-95	4	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	470	3	1	3	4.8	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1	10.1021/jm9017866
	46885972	8087	0	None	-165	4	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	456	4	1	3	4.4	CC(C)N1C[C@@H](C(=O)N2C[C@H](C)[C@@](O)(c3ccccc3)[C@H](C)C2)[C@H](c2ccc(F)cc2F)C1	10.1021/jm9017866
	CHEMBL1091631	8087	0	None	-165	4	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	456	4	1	3	4.4	CC(C)N1C[C@@H](C(=O)N2C[C@H](C)[C@@](O)(c3ccccc3)[C@H](C)C2)[C@H](c2ccc(F)cc2F)C1	10.1021/jm9017866
	11845630	139489	0	None	-4	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	678	15	5	6	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL379490	139489	0	None	-4	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	678	15	5	6	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL589515	215777	0	None	-169	4	Mouse	4.9	pEC50	=	4.9	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmc.2009.12.010
	25129453	171742	0	None	-15	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	677	11	3	5	3.9	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@@H]1Cc2ccccc2CN1	10.1021/jm800525p
	CHEMBL446757	171742	0	None	-15	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	677	11	3	5	3.9	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@@H]1Cc2ccccc2CN1	10.1021/jm800525p
	145966490	164338	0	None	-1	4	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	839	11	12	9	-1.2	CC1(C)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4212762	164338	0	None	-1	4	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	839	11	12	9	-1.2	CC1(C)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL3349030	211382	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorEffective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	CHEMBL2370967	209947	0	None	3	2	Human	7.9	pEC50	=	7.9	Functional	Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm030119t
	145980719	166472	0	None	-2	4	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assayAgonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assay	ChEMBL	642	17	7	6	1.6	CCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	CHEMBL4278563	166472	0	None	-2	4	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assayAgonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assay	ChEMBL	642	17	7	6	1.6	CCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	44322957	206188	0	None	-18	3	Human	6.9	pEC50	=	6.9	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	753	19	10	7	0.6	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CC(F)(F)F)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL86573	206188	0	None	-18	3	Human	6.9	pEC50	=	6.9	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	753	19	10	7	0.6	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CC(F)(F)F)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	44408189	168855	0	None	-107	4	Human	5.9	pEC50	=	5.9	Functional	Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation	ChEMBL	619	8	2	4	4.6	CN1CCN(CC2(C3CCCCC3)CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)C1=O	10.1016/j.bmcl.2005.11.095
	CHEMBL438259	168855	0	None	-107	4	Human	5.9	pEC50	=	5.9	Functional	Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation	ChEMBL	619	8	2	4	4.6	CN1CCN(CC2(C3CCCCC3)CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)C1=O	10.1016/j.bmcl.2005.11.095
	16132144	209256	36	None	-2	8	Mouse	5.9	pEC50	=	5.9	Functional	Compound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cellsCompound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/s0960-894x(03)00318-4
	16133793	209256	36	None	-2	8	Mouse	5.9	pEC50	=	5.9	Functional	Compound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cellsCompound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/s0960-894x(03)00318-4
	44273719	209256	36	None	-2	8	Mouse	5.9	pEC50	=	5.9	Functional	Compound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cellsCompound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/s0960-894x(03)00318-4
	CHEMBL214332	209256	36	None	-2	8	Mouse	5.9	pEC50	=	5.9	Functional	Compound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cellsCompound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/s0960-894x(03)00318-4
	44413881	137568	0	None	-4	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	707	15	6	7	1.9	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1C(=O)NCCN=C(N)N	10.1021/jm060384p
	CHEMBL375559	137568	0	None	-4	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	707	15	6	7	1.9	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1C(=O)NCCN=C(N)N	10.1021/jm060384p
	137635422	155886	0	None	-30	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1111	22	15	16	-2.3	CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	CHEMBL4060816	155886	0	None	-30	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1111	22	15	16	-2.3	CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	CHEMBL510687	215564	0	None	-141	4	Mouse	5.9	pEC50	=	5.9	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1cccc(Cl)c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	CHEMBL105113	208443	0	None	-30	4	Mouse	4.9	pEC50	=	4.9	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	CHEMBL264190	210585	1	None	-35	8	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	15603023	97936	0	None	-630	5	Mouse	5.9	pEC50	=	5.9	Functional	Agonist activity at mouse MC3R expressed in HEK293 cellsAgonist activity at mouse MC3R expressed in HEK293 cells	ChEMBL	849	12	10	8	0.0	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCC(=O)NCCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701093y
	CHEMBL272660	97936	0	None	-630	5	Mouse	5.9	pEC50	=	5.9	Functional	Agonist activity at mouse MC3R expressed in HEK293 cellsAgonist activity at mouse MC3R expressed in HEK293 cells	ChEMBL	849	12	10	8	0.0	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCC(=O)NCCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701093y
	CHEMBL5093939	215435	0	None	-169	4	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL2310901	209475	0	None	1	4	Human	7.9	pEC50	=	7.9	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm049579s
	44322958	106985	0	None	-2	3	Human	7.9	pEC50	=	7.9	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	727	18	9	7	0.4	CC(C)(C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL315356	106985	0	None	-2	3	Human	7.9	pEC50	=	7.9	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	727	18	9	7	0.4	CC(C)(C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL3600843	211797	0	None	1	4	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL5076315	214405	0	None	-8	4	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](C)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL501592	214118	0	None	-37	4	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2C[C@@H](NC(=N)N)CN2C1=O	10.1021/jm801300c
	44322986	106070	0	None	-18	3	Human	6.9	pEC50	=	6.9	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	713	19	9	7	0.1	CC(C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL313377	106070	0	None	-18	3	Human	6.9	pEC50	=	6.9	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	713	19	9	7	0.1	CC(C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	155567887	176024	0	None	-4	4	Mouse	5.9	pEC50	=	5.9	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	676	19	10	7	-1.1	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.9b00198
	CHEMBL4590532	176024	0	None	-4	4	Mouse	5.9	pEC50	=	5.9	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	676	19	10	7	-1.1	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.9b00198
	137640475	157063	0	None	-29	3	Mouse	4.9	pEC50	=	4.9	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	870	16	7	6	2.9	CC(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4074368	157063	0	None	-29	3	Mouse	4.9	pEC50	=	4.9	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	870	16	7	6	2.9	CC(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	1338	3778	43	None	-1202	8	Rat	5.9	pEC50	=	5.9	Functional	Functional activity as concentration at 50% maximum cAMP accumulation in rat Melanocortin-3 receptor (rMC3R)Functional activity as concentration at 50% maximum cAMP accumulation in rat Melanocortin-3 receptor (rMC3R)	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	9938402	3778	43	None	-1202	8	Rat	5.9	pEC50	=	5.9	Functional	Functional activity as concentration at 50% maximum cAMP accumulation in rat Melanocortin-3 receptor (rMC3R)Functional activity as concentration at 50% maximum cAMP accumulation in rat Melanocortin-3 receptor (rMC3R)	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	CHEMBL339053	3778	43	None	-1202	8	Rat	5.9	pEC50	=	5.9	Functional	Functional activity as concentration at 50% maximum cAMP accumulation in rat Melanocortin-3 receptor (rMC3R)Functional activity as concentration at 50% maximum cAMP accumulation in rat Melanocortin-3 receptor (rMC3R)	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	11308957	69364	0	None	-64	4	Mouse	6.9	pEC50	=	6.9	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL	868	31	9	7	4.5	CCCCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL193151	69364	0	None	-64	4	Mouse	6.9	pEC50	=	6.9	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL	868	31	9	7	4.5	CCCCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	44394093	127213	0	None	-8	3	Human	5.9	pEC50	=	5.9	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	881	19	9	6	3.5	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1c(F)c(F)c(F)c(F)c1F)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL365825	127213	0	None	-8	3	Human	5.9	pEC50	=	5.9	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	881	19	9	6	3.5	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1c(F)c(F)c(F)c(F)c1F)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL217584	209354	0	None	-74	3	Human	6.9	pEC50	=	6.9	Functional	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm960845e
	CHEMBL3350327	211447	0	None	-1	4	Mouse	4.9	pEC50	=	4.9	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)O	10.1021/jm0492756
	11846673	79965	0	None	-5	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	515	11	3	4	3.1	CC(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL212766	79965	0	None	-5	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	515	11	3	4	3.1	CC(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	11491374	67590	0	None	-147	4	Mouse	6.9	pEC50	=	6.9	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL	840	29	9	7	3.7	CCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL190366	67590	0	None	-147	4	Mouse	6.9	pEC50	=	6.9	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL	840	29	9	7	3.7	CCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL500743	214101	0	None	-1	4	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](NC(=N)N)CN2C1=O	10.1021/jm801300c
	162649653	180076	0	None	-23	3	Mouse	7.9	pEC50	=	7.9	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	753	18	10	7	0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	CHEMBL4748317	180076	0	None	-23	3	Mouse	7.9	pEC50	=	7.9	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	753	18	10	7	0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	162661397	181502	0	None	-2	4	Mouse	7.9	pEC50	=	7.9	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	725	17	8	7	0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	CHEMBL4765156	181502	0	None	-2	4	Mouse	7.9	pEC50	=	7.9	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	725	17	8	7	0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	162672755	183066	0	None	-35	3	Mouse	7.9	pEC50	=	7.9	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 6 hrs by beta-galactosidase cAMP assay	ChEMBL	734	16	8	7	1.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	CHEMBL4794484	183066	0	None	-35	3	Mouse	7.9	pEC50	=	7.9	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 6 hrs by beta-galactosidase cAMP assay	ChEMBL	734	16	8	7	1.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	44394786	124054	0	None	-3	3	Human	6.9	pEC50	=	6.9	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	883	22	9	7	3.5	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CCC(=O)c1cc(F)cc(F)c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL363271	124054	0	None	-3	3	Human	6.9	pEC50	=	6.9	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	883	22	9	7	3.5	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CCC(=O)c1cc(F)cc(F)c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL2096759	209185	0	None	-21	4	Human	6.9	pEC50	=	6.9	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON	10.1021/jm049579s
	122184914	122533	0	None	-69	4	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1144	17	9	11	1.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3601432	122533	0	None	-69	4	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1144	17	9	11	1.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	44422999	168831	0	None	-446	4	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human MC3R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC3R expressed in CHO cells assessed as cAMP accumulation	ChEMBL	1040	15	9	10	3.0	CCCC[C@H](NC(C)=O)C(=O)C[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	CHEMBL438118	168831	0	None	-446	4	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human MC3R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC3R expressed in CHO cells assessed as cAMP accumulation	ChEMBL	1040	15	9	10	3.0	CCCC[C@H](NC(C)=O)C(=O)C[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	155538472	173227	0	None	-10	3	Mouse	5.9	pEC50	=	5.9	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	664	14	6	7	0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4524668	173227	0	None	-10	3	Mouse	5.9	pEC50	=	5.9	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	664	14	6	7	0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	1338	3778	43	None	-616	8	Human	5.9	pEC50	=	5.9	Functional	In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 3 receptor (hMC3R)In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 3 receptor (hMC3R)	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/s0960-894x(03)00796-0
	9938402	3778	43	None	-616	8	Human	5.9	pEC50	=	5.9	Functional	In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 3 receptor (hMC3R)In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 3 receptor (hMC3R)	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/s0960-894x(03)00796-0
	CHEMBL339053	3778	43	None	-616	8	Human	5.9	pEC50	=	5.9	Functional	In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 3 receptor (hMC3R)In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 3 receptor (hMC3R)	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/s0960-894x(03)00796-0
	137634090	156275	0	None	-10	6	Mouse	4.9	pEC50	=	4.9	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL	3980	69	56	64	-22.2	CC(C)C[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc4cnc[nH]4)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc4ccccc4)C(=O)NC(=O)[C@H](CSSC[C@@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N3)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N2	10.1021/acs.jmedchem.8b00251
	CHEMBL4065418	156275	0	None	-10	6	Mouse	4.9	pEC50	=	4.9	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL	3980	69	56	64	-22.2	CC(C)C[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc4cnc[nH]4)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc4ccccc4)C(=O)NC(=O)[C@H](CSSC[C@@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N3)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N2	10.1021/acs.jmedchem.8b00251
	137635701	156013	0	None	-1	4	Mouse	4.9	pEC50	=	4.9	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	908	19	8	6	3.8	CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4062425	156013	0	None	-1	4	Mouse	4.9	pEC50	=	4.9	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	908	19	8	6	3.8	CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	162669632	182541	0	None	1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3ccc4ccccc4c3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4787753	182541	0	None	1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3ccc4ccccc4c3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	44416152	81069	0	None	-15	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	560	11	3	4	2.4	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)CCc2ccc(F)cc2)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL215576	81069	0	None	-15	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	560	11	3	4	2.4	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)CCc2ccc(F)cc2)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	44394657	127438	0	None	-12	3	Human	5.8	pEC50	=	5.8	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	745	19	10	7	0.5	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL366040	127438	0	None	-12	3	Human	5.8	pEC50	=	5.8	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	745	19	10	7	0.5	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	44394583	122319	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	771	18	8	6	2.4	CC(C)(C)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL359927	122319	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	771	18	8	6	2.4	CC(C)(C)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	44456964	156666	0	None	-81	4	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse MC3R expressed in HEK293 cellsAgonist activity at mouse MC3R expressed in HEK293 cells	ChEMBL	849	12	10	8	0.0	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701093y
	CHEMBL406985	156666	0	None	-81	4	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse MC3R expressed in HEK293 cellsAgonist activity at mouse MC3R expressed in HEK293 cells	ChEMBL	849	12	10	8	0.0	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701093y
	25129105	176995	0	None	-12	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	623	11	2	5	3.9	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)c1cccnc1	10.1021/jm800525p
	CHEMBL463047	176995	0	None	-12	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	623	11	2	5	3.9	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)c1cccnc1	10.1021/jm800525p
	44413968	80200	0	None	-77	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	632	12	5	5	4.0	N=C(N)NCCC[C@@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1Cc2ccccc2CN1	10.1021/jm060384p
	CHEMBL213751	80200	0	None	-77	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	632	12	5	5	4.0	N=C(N)NCCC[C@@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1Cc2ccccc2CN1	10.1021/jm060384p
	137658158	159693	0	None	-26	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1714	21	22	21	-3.6	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4104465	159693	0	None	-26	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1714	21	22	21	-3.6	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	9849434	176906	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	516	9	2	4	2.8	C=CC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@H](N)Cc1ccc(F)cc1	10.1021/jm800525p
	CHEMBL462044	176906	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	516	9	2	4	2.8	C=CC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@H](N)Cc1ccc(F)cc1	10.1021/jm800525p
	CHEMBL184968	209029	0	None	-11	3	Human	5.8	pEC50	=	5.8	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		CCC(=O)OC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	25133907	176700	0	None	-5	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	518	9	2	4	3.0	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@H](N)Cc1ccc(F)cc1	10.1021/jm800525p
	CHEMBL460138	176700	0	None	-5	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	518	9	2	4	3.0	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@H](N)Cc1ccc(F)cc1	10.1021/jm800525p
	44413914	139493	0	None	-50	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	652	15	5	6	2.6	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL379508	139493	0	None	-50	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	652	15	5	6	2.6	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	155555217	174313	0	None	-9	4	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	775	16	8	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4550976	174313	0	None	-9	4	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	775	16	8	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL307457	210958	0	None	-36	4	Mouse	7.8	pEC50	=	7.8	Functional	Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor	ChEMBL		None	None	None		CC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010061n
	CHEMBL5087814	215096	0	None	-12	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](C)C(=O)N2	10.1021/acs.jmedchem.1c00095
	44577516	172850	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	908	12	12	12	0.0	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc(N)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	CHEMBL451535	172850	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	908	12	12	12	0.0	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc(N)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	162664463	182166	0	None	-4	3	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	706	15	6	7	1.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	CHEMBL4782762	182166	0	None	-4	3	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	706	15	6	7	1.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	11273288	12928	0	None	-61	3	Human	6.8	pEC50	=	6.8	Functional	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 3 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 3 receptor	ChEMBL	585	8	3	5	3.6	CC[C@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1C	10.1016/j.bmcl.2005.02.068
	CHEMBL1189370	12928	0	None	-61	3	Human	6.8	pEC50	=	6.8	Functional	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 3 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 3 receptor	ChEMBL	585	8	3	5	3.6	CC[C@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1C	10.1016/j.bmcl.2005.02.068
	CHEMBL538567	12928	0	None	-61	3	Human	6.8	pEC50	=	6.8	Functional	Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 3 receptorConcentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 3 receptor	ChEMBL	585	8	3	5	3.6	CC[C@H]1CN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)CN1C	10.1016/j.bmcl.2005.02.068
	CHEMBL2370965	209945	0	None	-2	3	Human	6.8	pEC50	=	6.8	Functional	Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm030119t
	137657151	159532	0	None	-3	3	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	888	18	8	7	3.4	CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4102613	159532	0	None	-3	3	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	888	18	8	7	3.4	CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL50056	214096	2	None	-138	7	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.9b00198
	CHEMBL3349030	211382	0	None	1	3	Human	5.8	pEC50	=	5.8	Functional	Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorEffective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	CHEMBL320157	211203	0	None	-1	4	Mouse	4.8	pEC50	=	4.8	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 6 hrs by beta-galactosidase cAMP assay	ChEMBL		None	None	None		CC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.9b00198
	162672691	183177	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3cccc4ccccc34)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4795842	183177	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3cccc4ccccc34)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	11423083	96810	0	None	-154	4	Mouse	6.8	pEC50	=	6.8	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL	882	32	9	7	4.9	CCCCCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL265236	96810	0	None	-154	4	Mouse	6.8	pEC50	=	6.8	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL	882	32	9	7	4.9	CCCCCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	162672691	183177	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3cccc4ccccc34)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4795842	183177	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3cccc4ccccc34)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL264190	210585	1	None	-35	8	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	44448590	95570	0	None	-93	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MC3R expressed in CHO cells assessed as cAMP releaseAgonist activity at human MC3R expressed in CHO cells assessed as cAMP release	ChEMBL	571	7	1	4	6.3	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(OC)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL257759	95570	0	None	-93	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MC3R expressed in CHO cells assessed as cAMP releaseAgonist activity at human MC3R expressed in CHO cells assessed as cAMP release	ChEMBL	571	7	1	4	6.3	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(OC)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL3600842	211796	0	None	-2	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	132180598	157825	0	None	-181	4	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	803	17	10	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4083717	157825	0	None	-181	4	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	803	17	10	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL5077144	214462	0	None	-38	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	16132144	209256	36	None	-7	8	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acs.jmedchem.7b00353
	16133793	209256	36	None	-7	8	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acs.jmedchem.7b00353
	44273719	209256	36	None	-7	8	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acs.jmedchem.7b00353
	CHEMBL214332	209256	36	None	-7	8	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acs.jmedchem.7b00353
	1323	2669	55	None	-58	8	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	92432	2669	55	None	-58	8	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	CHEMBL430239	2669	55	None	-58	8	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	137637026	155901	0	None	-28	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1052	20	15	14	-1.4	CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	CHEMBL4060937	155901	0	None	-28	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1052	20	15	14	-1.4	CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	1338	3778	43	None	-616	8	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cellsAgonist activity at human MC3 receptor expressed in HEK293 cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2007.11.109
	9938402	3778	43	None	-616	8	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cellsAgonist activity at human MC3 receptor expressed in HEK293 cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2007.11.109
	CHEMBL339053	3778	43	None	-616	8	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cellsAgonist activity at human MC3 receptor expressed in HEK293 cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2007.11.109
	137639815	156778	0	None	-7	4	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	847	20	11	8	0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4071063	156778	0	None	-7	4	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	847	20	11	8	0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL264190	210585	1	None	-35	8	Mouse	6.8	pEC50	=	6.8	Functional	Agonistic activity evaluated at melanocortin 3 receptor (MC3R) of mouse HEK293 cellsAgonistic activity evaluated at melanocortin 3 receptor (MC3R) of mouse HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2003.08.078
	44322923	206523	0	None	-19	3	Human	6.8	pEC50	=	6.8	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	710	19	10	8	-0.5	N#CCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL88630	206523	0	None	-19	3	Human	6.8	pEC50	=	6.8	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	710	19	10	8	-0.5	N#CCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	10325955	165247	0	None	-112	2	Human	5.8	pEC50	=	5.8	Functional	Agonistic potency towards human Melanocortin 3 receptor (MC3R) was determined by 50% maximum cAMP releaseAgonistic potency towards human Melanocortin 3 receptor (MC3R) was determined by 50% maximum cAMP release	ChEMBL	582	8	2	6	3.7	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2Cn2ccnc2)CC1)[C@H]1Cc2ccccc2CN1	10.1021/jm0304109
	CHEMBL423101	165247	0	None	-112	2	Human	5.8	pEC50	=	5.8	Functional	Agonistic potency towards human Melanocortin 3 receptor (MC3R) was determined by 50% maximum cAMP releaseAgonistic potency towards human Melanocortin 3 receptor (MC3R) was determined by 50% maximum cAMP release	ChEMBL	582	8	2	6	3.7	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2Cn2ccnc2)CC1)[C@H]1Cc2ccccc2CN1	10.1021/jm0304109
	155562846	175146	0	None	-14	3	Mouse	4.8	pEC50	=	4.8	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	564	13	5	6	-0.2	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4570356	175146	0	None	-14	3	Mouse	4.8	pEC50	=	4.8	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	564	13	5	6	-0.2	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL184326	209026	0	None	-3	3	Human	5.8	pEC50	=	5.8	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		COP(=S)(N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)OC	10.1016/j.bmcl.2004.07.046
	CHEMBL3350396	211456	0	None	-281	4	Human	6.8	pEC50	=	6.8	Functional	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm960845e
	137662147	159355	0	None	-25	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1051	19	15	15	-3.0	C[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	CHEMBL4100598	159355	0	None	-25	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1051	19	15	15	-3.0	C[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	122184575	122401	0	None	1	4	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600836	122401	0	None	1	4	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	168272615	190363	0	None	-31	4	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1319	15	14	15	0.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSCc2ccc(cc2)CSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5177494	190363	0	None	-31	4	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1319	15	14	15	0.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSCc2ccc(cc2)CSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	44416060	81289	0	None	-102	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	734	13	5	6	2.2	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)C2Cc3ccccc3CN2)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL215895	81289	0	None	-102	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	734	13	5	6	2.2	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)C2Cc3ccccc3CN2)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	44394658	168313	0	None	-5	3	Human	6.8	pEC50	=	6.8	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	758	18	10	7	0.0	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)C(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL434329	168313	0	None	-5	3	Human	6.8	pEC50	=	6.8	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	758	18	10	7	0.0	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)C(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL500516	214094	0	None	-74	4	Mouse	4.8	pEC50	=	4.8	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(N)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	CHEMBL364359	211899	0	None	1	3	Human	5.8	pEC50	=	5.8	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NS(=O)(=O)C(F)(F)F)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL195468	209079	0	None	-53	4	Mouse	6.8	pEC50	=	6.8	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL		None	None	None		CCCCCCCCCCCCN[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	45487297	197078	0	None	-33	4	Mouse	4.8	pEC50	=	4.8	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL	613	17	8	6	0.7	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/C=C/c1ccccc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL567634	197078	0	None	-33	4	Mouse	4.8	pEC50	=	4.8	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL	613	17	8	6	0.7	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/C=C/c1ccccc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	162665450	182272	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3ccc4ccccc4c3)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4784053	182272	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3ccc4ccccc4c3)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	1323	2669	55	None	-58	8	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	92432	2669	55	None	-58	8	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	CHEMBL430239	2669	55	None	-58	8	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	44323031	168054	0	None	-33	3	Human	7.8	pEC50	=	7.8	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	775	21	10	7	1.2	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL432565	168054	0	None	-33	3	Human	7.8	pEC50	=	7.8	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	775	21	10	7	1.2	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL5075712	214371	0	None	-125	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	44394694	66282	0	None	-1	3	Human	6.8	pEC50	=	6.8	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	819	21	9	6	3.2	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL184895	66282	0	None	-1	3	Human	6.8	pEC50	=	6.8	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	819	21	9	6	3.2	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL183733	209024	0	None	-13	3	Human	6.8	pEC50	=	6.8	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL50056	214096	2	None	-15	7	Human	6.8	pEC50	=	6.8	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL203602	209137	0	None	-1	3	Human	5.8	pEC50	=	5.8	Functional	Activity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulation	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCC(N)=O)NC1=O	10.1021/jm0510326
	CHEMBL2370968	209948	0	None	-63	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human MC3R transfected in HEK293 cells assessed as cAMP accumulation by competitive binding assayAgonist activity at human MC3R transfected in HEK293 cells assessed as cAMP accumulation by competitive binding assay	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/acs.jmedchem.1c01295
	11753695	8361	7	None	-851	8	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse MC3 receptorAgonist activity at mouse MC3 receptor	ChEMBL	599	4	1	3	6.7	CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21	10.1016/j.bmcl.2010.06.062
	CHEMBL1093304	8361	7	None	-851	8	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse MC3 receptorAgonist activity at mouse MC3 receptor	ChEMBL	599	4	1	3	6.7	CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21	10.1016/j.bmcl.2010.06.062
	44305770	202771	0	None	1	4	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cellsAgonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells	ChEMBL	448	9	5	4	2.2	NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NN1CCc2ccccc2C1	10.1016/s0960-894x(03)00318-4
	CHEMBL62228	202771	0	None	1	4	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cellsAgonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells	ChEMBL	448	9	5	4	2.2	NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NN1CCc2ccccc2C1	10.1016/s0960-894x(03)00318-4
	CHEMBL2370968	209948	0	None	-63	4	Human	5.8	pEC50	=	5.8	Functional	Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm030119t
	CHEMBL264190	210585	1	None	-35	8	Mouse	6.8	pEC50	=	6.8	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	162665450	182272	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3ccc4ccccc4c3)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4784053	182272	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3ccc4ccccc4c3)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL302703	210891	0	None	-5	5	Mouse	5.8	pEC50	=	5.8	Functional	Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010061n
	CHEMBL361252	211811	0	None	-4	3	Human	6.8	pEC50	=	6.8	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		CN(C)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	11847312	79733	0	None	-6	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	613	12	6	6	1.8	N=C(N)NCCNC(=O)[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCCN1	10.1021/jm060384p
	CHEMBL211798	79733	0	None	-6	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	613	12	6	6	1.8	N=C(N)NCCNC(=O)[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCCN1	10.1021/jm060384p
	122184638	122411	0	None	2	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600919	122411	0	None	2	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL5092761	215365	0	None	-281	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL2323786	209489	0	None	-12	4	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	10077258	14999	0	None	-158	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationAgonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation	ChEMBL	596	8	0	5	4.5	CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)S(C)(=O)=O	10.1016/j.bmcl.2010.06.038
	CHEMBL1209253	14999	0	None	-158	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationAgonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation	ChEMBL	596	8	0	5	4.5	CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)S(C)(=O)=O	10.1016/j.bmcl.2010.06.038
	11226756	119948	0	None	-251	2	Human	5.8	pEC50	=	5.8	Functional	Agonistic potency towards human Melanocortin 3 receptor (MC3R) was determined by 50% maximum cAMP releaseAgonistic potency towards human Melanocortin 3 receptor (MC3R) was determined by 50% maximum cAMP release	ChEMBL	559	8	2	5	3.5	CN(C)Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1021/jm0304109
	CHEMBL349850	119948	0	None	-251	2	Human	5.8	pEC50	=	5.8	Functional	Agonistic potency towards human Melanocortin 3 receptor (MC3R) was determined by 50% maximum cAMP releaseAgonistic potency towards human Melanocortin 3 receptor (MC3R) was determined by 50% maximum cAMP release	ChEMBL	559	8	2	5	3.5	CN(C)Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1021/jm0304109
	155538874	172766	0	None	-10	3	Mouse	4.8	pEC50	=	4.8	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	713	16	8	7	-1.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4513460	172766	0	None	-10	3	Mouse	4.8	pEC50	=	4.8	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	713	16	8	7	-1.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	122184636	122409	0	None	-3	4	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600917	122409	0	None	-3	4	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL2323799	209502	0	None	-120	4	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	145976444	163939	0	None	-1	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	889	11	12	9	-0.1	CC1(C)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4207858	163939	0	None	-1	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	889	11	12	9	-0.1	CC1(C)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL3287327	211287	0	None	-7	5	Mouse	7.7	pEC50	=	7.7	Functional	Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O	10.1021/jm500064t
	CHEMBL438235	213736	0	None	3	3	Human	7.7	pEC50	=	7.7	Functional	Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@H]1C(=O)NCC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)CSSC1(C)C	10.1021/jm030119t
	137638778	156734	0	None	-11	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1053	18	14	15	-2.4	CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	CHEMBL4070639	156734	0	None	-11	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1053	18	14	15	-2.4	CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	CHEMBL5090670	215254	0	None	-18	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL2323793	209496	0	None	-25	4	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	168277258	190686	0	None	-39	4	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1243	15	14	15	-0.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSSCC[C@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5182345	190686	0	None	-39	4	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1243	15	14	15	-0.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSSCC[C@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL2323790	209493	0	None	-60	4	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	155555947	174488	0	None	-147	3	Mouse	4.7	pEC50	=	4.7	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	592	14	7	6	-0.2	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4555150	174488	0	None	-147	3	Mouse	4.7	pEC50	=	4.7	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	592	14	7	6	-0.2	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	168274920	190239	0	None	-66	4	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1319	15	14	15	0.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSCc2cccc(c2)CSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5175444	190239	0	None	-66	4	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1319	15	14	15	0.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSCc2cccc(c2)CSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL264190	210585	1	None	-35	8	Mouse	6.7	pEC50	=	6.7	Functional	Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010061n
	CHEMBL3601431	211804	0	None	-2	4	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	45487298	197319	0	None	-25	4	Mouse	4.7	pEC50	=	4.7	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL	657	17	8	8	0.4	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/C=C/c1ccc2c(c1)OCO2)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL568965	197319	0	None	-25	4	Mouse	4.7	pEC50	=	4.7	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL	657	17	8	8	0.4	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/C=C/c1ccc2c(c1)OCO2)C(N)=O	10.1016/j.bmcl.2009.07.025
	44415919	141563	0	None	4	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	780	16	6	7	1.9	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL385000	141563	0	None	4	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	780	16	6	7	1.9	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL503229	214140	0	None	-2	4	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm801300c
	44577510	188711	0	None	-3	4	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	893	12	11	11	0.4	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	CHEMBL504986	188711	0	None	-3	4	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	893	12	11	11	0.4	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	CHEMBL1688107	208811	0	None	-8	4	Mouse	8.7	pEC50	=	8.7	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	CHEMBL443071	213897	0	None	-2	4	Human	8.7	pEC50	=	8.7	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON	10.1021/jm049579s
	CHEMBL3349030	211382	0	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorEffective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	16132144	209256	36	None	-2	8	Mouse	8.7	pEC50	=	8.7	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm701303z
	16133793	209256	36	None	-2	8	Mouse	8.7	pEC50	=	8.7	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm701303z
	44273719	209256	36	None	-2	8	Mouse	8.7	pEC50	=	8.7	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm701303z
	CHEMBL214332	209256	36	None	-2	8	Mouse	8.7	pEC50	=	8.7	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm701303z
	CHEMBL5087839	215097	0	None	-2	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc3ccccc3c1)C(=O)N[C@@H](C)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL3358533	211544	0	None	-4	4	Mouse	8.7	pEC50	=	8.7	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C#CC[C@H](NC(=O)[C@H](CCCC)NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN=[N+]=[N-])C(N)=O	10.1021/jm501027w
	118722932	115492	0	None	-10	4	Mouse	8.6	pEC50	=	8.6	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1038	33	13	11	1.2	CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCN=[N+]=[N-])C(N)=O	10.1021/jm501027w
	CHEMBL3352878	115492	0	None	-10	4	Mouse	8.6	pEC50	=	8.6	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1038	33	13	11	1.2	CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCN=[N+]=[N-])C(N)=O	10.1021/jm501027w
	10408	717	28	None	-5	4	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.8b00170
	5329	717	28	None	-5	4	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.8b00170
	9941379	717	28	None	-5	4	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.8b00170
	CHEMBL2070241	717	28	None	-5	4	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.8b00170
	DB11653	717	28	None	-5	4	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.8b00170
	1323	2669	55	None	-58	8	Human	8.6	pEC50	=	8.6	Functional	Activity at human MC3R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulationActivity at human MC3R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1016/j.bmcl.2006.07.015
	92432	2669	55	None	-58	8	Human	8.6	pEC50	=	8.6	Functional	Activity at human MC3R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulationActivity at human MC3R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1016/j.bmcl.2006.07.015
	CHEMBL430239	2669	55	None	-58	8	Human	8.6	pEC50	=	8.6	Functional	Activity at human MC3R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulationActivity at human MC3R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1016/j.bmcl.2006.07.015
	CHEMBL3358542	211546	0	None	-7	3	Mouse	8.6	pEC50	=	8.6	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(C)=O)C(N)=O	10.1021/jm501027w
	168278271	191091	0	None	-5	4	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2167	35	34	26	-5.3	CCCC[C@@H]1NC(=O)[C@@H]2CS/C(C(=O)O)=C(/C(N)=O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5187932	191091	0	None	-5	4	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	2167	35	34	26	-5.3	CCCC[C@@H]1NC(=O)[C@@H]2CS/C(C(=O)O)=C(/C(N)=O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	16132144	209256	36	None	-7	8	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm9017866
	16133793	209256	36	None	-7	8	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm9017866
	44273719	209256	36	None	-7	8	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm9017866
	CHEMBL214332	209256	36	None	-7	8	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm9017866
	44348200	160172	0	None	2	3	Human	8.6	pEC50	=	8.6	Functional	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL	1511	33	16	22	-1.7	CC(=O)C1C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NC(C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)CSSC1(C)C	10.1021/jm030111j
	CHEMBL410949	160172	0	None	2	3	Human	8.6	pEC50	=	8.6	Functional	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL	1511	33	16	22	-1.7	CC(=O)C1C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NC(C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)CSSC1(C)C	10.1021/jm030111j
	CHEMBL266417	210660	0	None	-83	6	Human	8.6	pEC50	=	8.6	Functional	Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm00018a005
	CHEMBL4299619	213572	0	None	-66	4	Mouse	7.7	pEC50	=	7.7	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		CC(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@@H]1C(=O)NCC(=O)N1CCC[C@@H]1C(=O)NCC(=O)N1CCC[C@@H]1C(=O)NCC(=O)N1CCC[C@@H]1C(=O)NCC(=O)N1CCC[C@@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	137660993	159423	0	None	-13	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1680	20	21	21	-3.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4101216	159423	0	None	-13	4	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1680	20	21	21	-3.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL2323785	209488	0	None	-32	4	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	118735102	118776	0	None	-53	4	Human	5.7	pEC50	=	5.7	Functional	Activity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterActivity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counter	ChEMBL	707	15	8	6	1.1	CC(=O)N[C@H]1Cc2ccccc2CN([C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	CHEMBL3421679	118776	0	None	-53	4	Human	5.7	pEC50	=	5.7	Functional	Activity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterActivity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counter	ChEMBL	707	15	8	6	1.1	CC(=O)N[C@H]1Cc2ccccc2CN([C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	10257242	14998	0	None	-112	4	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationAgonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation	ChEMBL	560	7	0	4	5.1	CC(=O)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(C)C	10.1016/j.bmcl.2010.06.038
	CHEMBL1209252	14998	0	None	-112	4	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationAgonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation	ChEMBL	560	7	0	4	5.1	CC(=O)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(C)C	10.1016/j.bmcl.2010.06.038
	155548791	173706	0	None	-25	4	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	664	14	6	7	0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4536340	173706	0	None	-25	4	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	664	14	6	7	0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	164627491	186479	0	None	3	3	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	587	11	3	3	5.8	CCC[C@@H]1CN([C@H](Cc2ccccc2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C(=N)N1CC12CC3CC(CC(C3)C1)C2	10.1021/acs.jmedchem.0c02041
	CHEMBL4877442	186479	0	None	3	3	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	587	11	3	3	5.8	CCC[C@@H]1CN([C@H](Cc2ccccc2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C(=N)N1CC12CC3CC(CC(C3)C1)C2	10.1021/acs.jmedchem.0c02041
	9960253	116923	0	None	-25	2	Human	5.7	pEC50	=	5.7	Functional	Agonistic potency towards human Melanocortin 3 receptor (MC3R) was determined by 50% maximum cAMP releaseAgonistic potency towards human Melanocortin 3 receptor (MC3R) was determined by 50% maximum cAMP release	ChEMBL	595	8	3	6	2.8	CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1021/jm0304109
	CHEMBL338594	116923	0	None	-25	2	Human	5.7	pEC50	=	5.7	Functional	Agonistic potency towards human Melanocortin 3 receptor (MC3R) was determined by 50% maximum cAMP releaseAgonistic potency towards human Melanocortin 3 receptor (MC3R) was determined by 50% maximum cAMP release	ChEMBL	595	8	3	6	2.8	CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1021/jm0304109
	44409240	74405	0	None	-457	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	736	18	8	7	1.3	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O	10.1016/j.bmcl.2006.05.087
	CHEMBL202699	74405	0	None	-457	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	736	18	8	7	1.3	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O	10.1016/j.bmcl.2006.05.087
	44415972	79854	0	None	-141	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	549	13	6	5	0.9	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)Cc1ccc(F)cc1	10.1016/j.bmcl.2006.05.087
	CHEMBL212332	79854	0	None	-141	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	549	13	6	5	0.9	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)Cc1ccc(F)cc1	10.1016/j.bmcl.2006.05.087
	44415956	141931	0	None	-24	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	531	13	6	5	0.7	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)Cc1ccccc1	10.1016/j.bmcl.2006.05.087
	CHEMBL387246	141931	0	None	-24	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	531	13	6	5	0.7	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)Cc1ccccc1	10.1016/j.bmcl.2006.05.087
	44409240	74405	0	None	-457	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	736	18	8	7	1.3	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O	10.1021/jm060384p
	CHEMBL202699	74405	0	None	-457	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	736	18	8	7	1.3	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O	10.1021/jm060384p
	44413832	78036	0	None	-38	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	584	12	5	5	3.5	N=C(N)NCCC[C@@H]1C[C@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCCCN1	10.1021/jm060384p
	CHEMBL210009	78036	0	None	-38	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	584	12	5	5	3.5	N=C(N)NCCC[C@@H]1C[C@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCCCN1	10.1021/jm060384p
	11845444	80038	0	None	-11	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	678	15	5	6	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL213026	80038	0	None	-11	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	678	15	5	6	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N	10.1021/jm060384p
	44413969	80201	0	None	-44	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	584	12	5	5	3.5	N=C(N)NCCC[C@@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCCCN1	10.1021/jm060384p
	CHEMBL213752	80201	0	None	-44	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	584	12	5	5	3.5	N=C(N)NCCC[C@@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCCCN1	10.1021/jm060384p
	44413970	138990	0	None	-50	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	587	14	5	6	1.3	NC(=O)C[C@H](N)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL378571	138990	0	None	-50	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	587	14	5	6	1.3	NC(=O)C[C@H](N)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N	10.1021/jm060384p
	44415956	141931	0	None	-24	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	531	13	6	5	0.7	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)Cc1ccccc1	10.1021/jm060384p
	CHEMBL387246	141931	0	None	-24	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	531	13	6	5	0.7	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)Cc1ccccc1	10.1021/jm060384p
	44394785	124014	0	None	-4	3	Human	6.7	pEC50	=	6.7	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	865	22	9	7	3.3	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CCC(=O)c1ccc(F)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL363061	124014	0	None	-4	3	Human	6.7	pEC50	=	6.7	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	865	22	9	7	3.3	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CCC(=O)c1ccc(F)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	137631599	156502	0	None	-50	4	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1694	20	20	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4067967	156502	0	None	-50	4	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1694	20	20	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL319871	211201	0	None	-177	4	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	44457043	97584	0	None	-204	5	Mouse	4.7	pEC50	=	4.7	Functional	Agonist activity at mouse MC3R expressed in HEK293 cellsAgonist activity at mouse MC3R expressed in HEK293 cells	ChEMBL	883	12	10	8	0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)c2ccccc2C(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701093y
	CHEMBL270923	97584	0	None	-204	5	Mouse	4.7	pEC50	=	4.7	Functional	Agonist activity at mouse MC3R expressed in HEK293 cellsAgonist activity at mouse MC3R expressed in HEK293 cells	ChEMBL	883	12	10	8	0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)c2ccccc2C(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701093y
	45487415	197416	0	None	-245	4	Mouse	4.7	pEC50	=	4.7	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL	603	16	9	7	-0.2	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccc(O)cc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL569697	197416	0	None	-245	4	Mouse	4.7	pEC50	=	4.7	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL	603	16	9	7	-0.2	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccc(O)cc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	11845276	80024	0	None	-7	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	605	14	4	4	4.9	N=C(N)NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)CCc1ccccc1	10.1021/jm060384p
	CHEMBL212976	80024	0	None	-7	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	605	14	4	4	4.9	N=C(N)NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)CCc1ccccc1	10.1021/jm060384p
	44394695	123132	0	None	-2	3	Human	6.7	pEC50	=	6.7	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	833	22	9	6	3.6	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL361253	123132	0	None	-2	3	Human	6.7	pEC50	=	6.7	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	833	22	9	6	3.6	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	155563222	175267	0	None	-69	4	Mouse	7.7	pEC50	=	7.7	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	711	17	10	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4572994	175267	0	None	-69	4	Mouse	7.7	pEC50	=	7.7	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	711	17	10	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL3287329	211288	0	None	-4	5	Mouse	7.7	pEC50	=	7.7	Functional	Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O	10.1021/jm500064t
	155558348	175012	0	None	-11	4	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	677	19	9	7	-0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4567480	175012	0	None	-11	4	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	677	19	9	7	-0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	155562237	175685	0	None	-104	4	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	692	15	8	7	0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4582276	175685	0	None	-104	4	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	692	15	8	7	0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	164623811	185876	0	None	-1	4	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	614	11	4	4	6.2	CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H]([C@@H](C)O)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4868636	185876	0	None	-1	4	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	614	11	4	4	6.2	CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H]([C@@H](C)O)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL427629	213334	0	None	-1	3	Human	6.7	pEC50	=	6.7	Functional	Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC1=O	10.1021/jm030119t
	137655905	158804	0	None	-51	4	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1666	20	22	21	-3.9	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4094606	158804	0	None	-51	4	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1666	20	22	21	-3.9	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	44413828	139268	0	None	-5	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	632	12	5	5	4.0	N=C(N)NCCC[C@H]1C[C@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1Cc2ccccc2CN1	10.1021/jm060384p
	CHEMBL379168	139268	0	None	-5	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	632	12	5	5	4.0	N=C(N)NCCC[C@H]1C[C@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1Cc2ccccc2CN1	10.1021/jm060384p
	25132864	172578	0	None	-42	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	590	12	2	5	2.8	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)COC	10.1021/jm800525p
	CHEMBL449050	172578	0	None	-42	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	590	12	2	5	2.8	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)COC	10.1021/jm800525p
	162672755	183066	0	None	-35	3	Mouse	7.7	pEC50	=	7.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	734	16	8	7	1.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	CHEMBL4794484	183066	0	None	-35	3	Mouse	7.7	pEC50	=	7.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	734	16	8	7	1.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	90643805	111718	0	None	-7	5	Mouse	7.7	pEC50	=	7.7	Functional	Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL	917	20	11	7	-0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O	10.1021/jm500064t
	CHEMBL3287325	111718	0	None	-7	5	Mouse	7.7	pEC50	=	7.7	Functional	Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL	917	20	11	7	-0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O	10.1021/jm500064t
	127047853	139968	0	None	-123	5	Mouse	7.6	pEC50	=	7.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	1948	72	23	25	-2.1	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL3799955	139968	0	None	-123	5	Mouse	7.6	pEC50	=	7.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	1948	72	23	25	-2.1	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	164610489	184531	0	None	-1	3	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	600	10	4	4	5.8	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H]([C@@H](C)O)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4848322	184531	0	None	-1	3	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	600	10	4	4	5.8	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H]([C@@H](C)O)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	11239907	133102	0	None	-380	4	Mouse	6.7	pEC50	=	6.7	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL	854	30	9	7	4.1	CCCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL370261	133102	0	None	-380	4	Mouse	6.7	pEC50	=	6.7	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL	854	30	9	7	4.1	CCCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	137634090	156275	0	None	-15	6	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at human MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL	3980	69	56	64	-22.2	CC(C)C[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc4cnc[nH]4)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc4ccccc4)C(=O)NC(=O)[C@H](CSSC[C@@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N3)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N2	10.1021/acs.jmedchem.8b00251
	CHEMBL4065418	156275	0	None	-15	6	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayAgonist activity at human MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assay	ChEMBL	3980	69	56	64	-22.2	CC(C)C[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc4cnc[nH]4)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc4ccccc4)C(=O)NC(=O)[C@H](CSSC[C@@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N3)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N2	10.1021/acs.jmedchem.8b00251
	CHEMBL2323529	209487	0	None	-28	4	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	CHEMBL2369131	209570	0	None	-6	4	Mouse	4.7	pEC50	=	4.7	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)O	10.1021/jm0492756
	CHEMBL5081077	214694	0	None	-29	4	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CN1C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]1CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	9867330	97813	0	None	-14	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cellsAgonist activity at human MC3 receptor expressed in HEK293 cells	ChEMBL	429	6	1	5	3.7	N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(Cn2cncn2)(C2CCCCC2)CC1	10.1016/j.bmcl.2007.11.109
	CHEMBL272099	97813	0	None	-14	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cellsAgonist activity at human MC3 receptor expressed in HEK293 cells	ChEMBL	429	6	1	5	3.7	N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(Cn2cncn2)(C2CCCCC2)CC1	10.1016/j.bmcl.2007.11.109
	CHEMBL2323787	209490	0	None	-11	4	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	44441684	94102	0	None	-28	3	Human	6.6	pEC50	=	6.6	Functional	Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production	ChEMBL	571	7	3	5	3.1	CC1CCC(C2(C(=O)NC(C)(C)C)CCN(C(=O)[C@H](Cc3ccc(F)cc3)NC(=O)[C@H]3CN(C)CCN3)CC2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL249321	94102	0	None	-28	3	Human	6.6	pEC50	=	6.6	Functional	Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production	ChEMBL	571	7	3	5	3.1	CC1CCC(C2(C(=O)NC(C)(C)C)CCN(C(=O)[C@H](Cc3ccc(F)cc3)NC(=O)[C@H]3CN(C)CCN3)CC2)CC1	10.1016/j.bmcl.2006.11.084
	44323015	111406	0	None	-25	3	Human	6.6	pEC50	=	6.6	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	731	20	9	8	-0.2	CSCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL327450	111406	0	None	-25	3	Human	6.6	pEC50	=	6.6	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	731	20	9	8	-0.2	CSCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	137657206	159647	0	None	1	3	Mouse	5.6	pEC50	=	5.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	914	19	8	7	3.9	CC(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4103985	159647	0	None	1	3	Mouse	5.6	pEC50	=	5.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	914	19	8	7	3.9	CC(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	11845272	80329	0	None	-23	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	632	12	5	5	4.0	N=C(N)NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1	10.1021/jm060384p
	CHEMBL214347	80329	0	None	-23	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	632	12	5	5	4.0	N=C(N)NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1	10.1021/jm060384p
	44457002	97544	0	None	-5	3	Mouse	4.6	pEC50	=	4.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	ChEMBL	440	4	1	2	5.4	O=C1NC(Cc2ccccc2)C(=O)N(Cc2ccc3ccccc3c2)c2cc(Cl)ccc21	10.1021/jm701303z
	CHEMBL270691	97544	0	None	-5	3	Mouse	4.6	pEC50	=	4.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	ChEMBL	440	4	1	2	5.4	O=C1NC(Cc2ccccc2)C(=O)N(Cc2ccc3ccccc3c2)c2cc(Cl)ccc21	10.1021/jm701303z
	44394626	65754	0	None	-14	3	Human	5.6	pEC50	=	5.6	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	743	19	8	6	1.7	CCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL183476	65754	0	None	-14	3	Human	5.6	pEC50	=	5.6	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	743	19	8	6	1.7	CCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	25132524	176734	0	None	-7	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	504	8	2	4	2.7	CC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@H](N)Cc1ccc(F)cc1	10.1021/jm800525p
	CHEMBL460349	176734	0	None	-7	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	504	8	2	4	2.7	CC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@H](N)Cc1ccc(F)cc1	10.1021/jm800525p
	122184637	122410	0	None	-3	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600918	122410	0	None	-3	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL448536	213936	0	None	-85	4	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(C#N)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	164619151	185530	0	None	1	4	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	610	11	4	4	5.5	CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H]([C@@H](C)O)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4863206	185530	0	None	1	4	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	610	11	4	4	5.5	CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H]([C@@H](C)O)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL409636	212750	0	None	-1	3	Human	6.6	pEC50	=	6.6	Functional	Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm030119t
	44397461	126201	0	None	-27	3	Human	5.6	pEC50	=	5.6	Functional	Effective concentration against human melanocortin 3 receptor in cAMP release assayEffective concentration against human melanocortin 3 receptor in cAMP release assay	ChEMBL	606	10	2	7	5.6	COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNC[C@@H]3c3ccc(F)cc3)c2=O)cc1	10.1016/j.bmcl.2005.06.033
	CHEMBL365005	126201	0	None	-27	3	Human	5.6	pEC50	=	5.6	Functional	Effective concentration against human melanocortin 3 receptor in cAMP release assayEffective concentration against human melanocortin 3 receptor in cAMP release assay	ChEMBL	606	10	2	7	5.6	COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNC[C@@H]3c3ccc(F)cc3)c2=O)cc1	10.1016/j.bmcl.2005.06.033
	CHEMBL2370963	209943	0	None	-85	2	Human	5.6	pEC50	=	5.6	Functional	Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm030119t
	44441685	94103	0	None	1	3	Human	6.6	pEC50	=	6.6	Functional	Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production	ChEMBL	585	7	3	5	3.5	CN1CCN[C@@H](C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCC(C)(C)CC3)CC2)C1	10.1016/j.bmcl.2006.11.084
	CHEMBL249322	94103	0	None	1	3	Human	6.6	pEC50	=	6.6	Functional	Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production	ChEMBL	585	7	3	5	3.5	CN1CCN[C@@H](C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCC(C)(C)CC3)CC2)C1	10.1016/j.bmcl.2006.11.084
	45487294	196790	0	None	-23	4	Mouse	4.6	pEC50	=	4.6	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL	601	17	8	6	0.5	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C/C=C/c1ccccc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL565688	196790	0	None	-23	4	Mouse	4.6	pEC50	=	4.6	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL	601	17	8	6	0.5	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C/C=C/c1ccccc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	118735101	118775	0	None	-64	4	Human	5.6	pEC50	=	5.6	Functional	Activity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterActivity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counter	ChEMBL	824	15	9	6	2.4	CC(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN([C@H](Cc2ccc(Br)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	CHEMBL3421678	118775	0	None	-64	4	Human	5.6	pEC50	=	5.6	Functional	Activity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterActivity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counter	ChEMBL	824	15	9	6	2.4	CC(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN([C@H](Cc2ccc(Br)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	CHEMBL433296	213613	0	None	-39	4	Mouse	5.6	pEC50	=	5.6	Functional	Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010061n
	168295131	192218	0	None	-16	4	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysisAgonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysis	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccc(cc2)CSC(C)(C)[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	CHEMBL5205283	192218	0	None	-16	4	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysisAgonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysis	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccc(cc2)CSC(C)(C)[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	11845440	138647	0	None	-23	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	613	12	6	6	1.7	N=C(N)NCCNC(=O)[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCNCC1	10.1021/jm060384p
	CHEMBL377778	138647	0	None	-23	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	613	12	6	6	1.7	N=C(N)NCCNC(=O)[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCNCC1	10.1021/jm060384p
	CHEMBL50056	214096	2	None	-15	7	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm060384p
	1338	3778	43	None	-616	8	Human	5.6	pEC50	=	5.6	Functional	Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2005.11.095
	9938402	3778	43	None	-616	8	Human	5.6	pEC50	=	5.6	Functional	Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2005.11.095
	CHEMBL339053	3778	43	None	-616	8	Human	5.6	pEC50	=	5.6	Functional	Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2005.11.095
	1338	3778	43	None	-616	8	Human	5.6	pEC50	=	5.6	Functional	Evaluated for Functional Activity at MC3R as effective concentration at 50% maximum CMP accumulationEvaluated for Functional Activity at MC3R as effective concentration at 50% maximum CMP accumulation	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	9938402	3778	43	None	-616	8	Human	5.6	pEC50	=	5.6	Functional	Evaluated for Functional Activity at MC3R as effective concentration at 50% maximum CMP accumulationEvaluated for Functional Activity at MC3R as effective concentration at 50% maximum CMP accumulation	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	CHEMBL339053	3778	43	None	-616	8	Human	5.6	pEC50	=	5.6	Functional	Evaluated for Functional Activity at MC3R as effective concentration at 50% maximum CMP accumulationEvaluated for Functional Activity at MC3R as effective concentration at 50% maximum CMP accumulation	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	1338	3778	43	None	-616	8	Human	5.6	pEC50	=	5.6	Functional	Functional activity as concentration at 50% maximum cAMP accumulation in human melanocortin 1 (MC3R) receptorFunctional activity as concentration at 50% maximum cAMP accumulation in human melanocortin 1 (MC3R) receptor	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	9938402	3778	43	None	-616	8	Human	5.6	pEC50	=	5.6	Functional	Functional activity as concentration at 50% maximum cAMP accumulation in human melanocortin 1 (MC3R) receptorFunctional activity as concentration at 50% maximum cAMP accumulation in human melanocortin 1 (MC3R) receptor	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	CHEMBL339053	3778	43	None	-616	8	Human	5.6	pEC50	=	5.6	Functional	Functional activity as concentration at 50% maximum cAMP accumulation in human melanocortin 1 (MC3R) receptorFunctional activity as concentration at 50% maximum cAMP accumulation in human melanocortin 1 (MC3R) receptor	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	44448660	94944	0	None	-691	4	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MC3R expressed in CHO cells assessed as cAMP releaseAgonist activity at human MC3R expressed in CHO cells assessed as cAMP release	ChEMBL	575	6	1	3	6.9	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Cl)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL254589	94944	0	None	-691	4	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MC3R expressed in CHO cells assessed as cAMP releaseAgonist activity at human MC3R expressed in CHO cells assessed as cAMP release	ChEMBL	575	6	1	3	6.9	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Cl)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	44569175	188798	0	None	-12	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	629	11	3	5	2.5	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1CCC(=O)N1	10.1021/jm800525p
	CHEMBL506272	188798	0	None	-12	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	629	11	3	5	2.5	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1CCC(=O)N1	10.1021/jm800525p
	1323	2669	55	None	-58	8	Human	7.6	pEC50	=	7.6	Functional	Agonistic activity against human melanocortin receptor (hMC3R) for cAMP accumulationAgonistic activity against human melanocortin receptor (hMC3R) for cAMP accumulation	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00114-8
	92432	2669	55	None	-58	8	Human	7.6	pEC50	=	7.6	Functional	Agonistic activity against human melanocortin receptor (hMC3R) for cAMP accumulationAgonistic activity against human melanocortin receptor (hMC3R) for cAMP accumulation	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00114-8
	CHEMBL430239	2669	55	None	-58	8	Human	7.6	pEC50	=	7.6	Functional	Agonistic activity against human melanocortin receptor (hMC3R) for cAMP accumulationAgonistic activity against human melanocortin receptor (hMC3R) for cAMP accumulation	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00114-8
	CHEMBL410795	212819	0	None	1	3	Human	6.6	pEC50	=	6.6	Functional	Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorEffective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	CHEMBL370254	212143	3	None	-91	4	Mouse	6.6	pEC50	=	6.6	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL		None	None	None		NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]cn1	10.1021/jm0490843
	49862425	15028	0	None	-91	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationAgonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation	ChEMBL	570	9	0	5	4.0	CC(C)CC(CN(C(C)C)S(C)(=O)=O)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1	10.1016/j.bmcl.2010.06.038
	CHEMBL1209382	15028	0	None	-91	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationAgonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation	ChEMBL	570	9	0	5	4.0	CC(C)CC(CN(C(C)C)S(C)(=O)=O)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1	10.1016/j.bmcl.2010.06.038
	CHEMBL524861	215600	0	None	-17	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@H](NC(=N)N)CN2C1=O	10.1021/jm801300c
	137640715	156979	0	None	-34	3	Mouse	5.6	pEC50	=	5.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	850	15	7	7	2.5	CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4073316	156979	0	None	-34	3	Mouse	5.6	pEC50	=	5.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	850	15	7	7	2.5	CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	137649203	157484	0	None	-1	3	Mouse	5.6	pEC50	=	5.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	894	18	8	8	3.5	CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4079721	157484	0	None	-1	3	Mouse	5.6	pEC50	=	5.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	894	18	8	8	3.5	CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	145990599	166831	0	None	-4	4	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assayAgonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assay	ChEMBL	710	17	7	6	2.6	CCCC[C@H](NC(=O)[C@@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	CHEMBL4285535	166831	0	None	-4	4	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assayAgonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assay	ChEMBL	710	17	7	6	2.6	CCCC[C@H](NC(=O)[C@@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	CHEMBL2323798	209501	0	None	-85	4	Mouse	5.6	pEC50	=	5.6	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCCN)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	145980198	166662	0	None	-1	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assayAgonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assay	ChEMBL	692	17	7	6	2.7	CCCC[C@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	CHEMBL4282109	166662	0	None	-1	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assayAgonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assay	ChEMBL	692	17	7	6	2.7	CCCC[C@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	45487299	197352	0	None	-48	2	Mouse	4.6	pEC50	=	4.6	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL	661	19	8	8	0.5	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCCCc1ccc2c(c1)OCO2)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL569222	197352	0	None	-48	2	Mouse	4.6	pEC50	=	4.6	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL	661	19	8	8	0.5	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCCCc1ccc2c(c1)OCO2)C(N)=O	10.1016/j.bmcl.2009.07.025
	155544214	173307	0	None	-8	3	Mouse	7.6	pEC50	=	7.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	797	20	11	7	-0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4526652	173307	0	None	-8	3	Mouse	7.6	pEC50	=	7.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	797	20	11	7	-0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	45487403	197412	0	None	-2630	5	Mouse	7.6	pEC50	=	7.6	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL	788	22	9	7	2.4	N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CC1=CN=CC1)NC(=O)CCCc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL569693	197412	0	None	-2630	5	Mouse	7.6	pEC50	=	7.6	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL	788	22	9	7	2.4	N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CC1=CN=CC1)NC(=O)CCCc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2009.07.025
	11846669	80248	0	None	-18	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	584	12	5	5	3.5	N=C(N)NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCCN1	10.1021/jm060384p
	CHEMBL213956	80248	0	None	-18	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	584	12	5	5	3.5	N=C(N)NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCCN1	10.1021/jm060384p
	137656489	159686	0	None	-14	4	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	1125	13	13	12	-1.2	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.6b01707
	CHEMBL4104402	159686	0	None	-14	4	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	1125	13	13	12	-1.2	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.6b01707
	10886436	119131	0	None	-537	5	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	588	8	2	6	4.6	O=C(N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(Cn2cncn2)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1021/acs.jmedchem.0c02041
	CHEMBL342954	119131	0	None	-537	5	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	588	8	2	6	4.6	O=C(N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(Cn2cncn2)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1021/acs.jmedchem.0c02041
	44441644	154814	0	None	-69	3	Human	6.6	pEC50	=	6.6	Functional	Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production	ChEMBL	577	9	2	7	3.5	CCC(C)C1(Cc2nnnn2C)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL400456	154814	0	None	-69	3	Human	6.6	pEC50	=	6.6	Functional	Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production	ChEMBL	577	9	2	7	3.5	CCC(C)C1(Cc2nnnn2C)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL434357	213629	0	None	-19	3	Human	5.6	pEC50	=	5.6	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		COP(=O)(N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)OC	10.1016/j.bmcl.2004.07.046
	44413880	77917	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	639	14	6	7	0.7	NC(N)=NCCNC(=O)[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]cn1	10.1021/jm060384p
	CHEMBL209587	77917	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	639	14	6	7	0.7	NC(N)=NCCNC(=O)[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]cn1	10.1021/jm060384p
	11263053	67991	0	None	-363	4	Mouse	6.6	pEC50	=	6.6	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL	896	33	9	7	5.3	CCCCCCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL191304	67991	0	None	-363	4	Mouse	6.6	pEC50	=	6.6	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL	896	33	9	7	5.3	CCCCCCCCCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	137659790	159298	0	None	-11	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1728	21	21	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4099889	159298	0	None	-11	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1728	21	21	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	137653925	158583	0	None	-64	4	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1742	21	20	21	-2.9	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4092141	158583	0	None	-64	4	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1742	21	20	21	-2.9	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL427205	213329	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Activity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulation	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)NC1=O	10.1021/jm0510326
	24774602	168907	0	None	2	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL	766	9	10	9	-0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)c2nccnc2C(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL438744	168907	0	None	2	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL	766	9	10	9	-0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)c2nccnc2C(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL3799094	212245	0	None	-97	5	Mouse	7.6	pEC50	=	7.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL2115441	209245	0	None	-144	4	Human	7.6	pEC50	=	7.6	Functional	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm960845e
	155549385	173781	0	None	-4	4	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	756	14	6	7	-0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4538225	173781	0	None	-4	4	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	756	14	6	7	-0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	25132525	176701	0	None	-3	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	518	8	2	4	2.9	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](C(C)C)C1=O	10.1021/jm800525p
	CHEMBL460142	176701	0	None	-3	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	518	8	2	4	2.9	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](C(C)C)C1=O	10.1021/jm800525p
	145971673	164674	0	None	-4	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	837	11	12	9	-1.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4217191	164674	0	None	-4	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	837	11	12	9	-1.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	44400428	125651	0	None	-331	4	Mouse	6.6	pEC50	=	6.6	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL	896	35	9	7	6.1	CCCCCCCCCCCCCCCCCCN[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL364726	125651	0	None	-331	4	Mouse	6.6	pEC50	=	6.6	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL	896	35	9	7	6.1	CCCCCCCCCCCCCCCCCCN[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	44323032	206581	0	None	-14	3	Human	7.6	pEC50	=	7.6	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	761	20	10	7	0.8	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL89004	206581	0	None	-14	3	Human	7.6	pEC50	=	7.6	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	761	20	10	7	0.8	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	162672255	182847	0	None	-1	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1100	18	14	11	0.6	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4791788	182847	0	None	-1	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1100	18	14	11	0.6	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL383250	212289	0	None	-18	3	Human	5.6	pEC50	=	5.6	Functional	Activity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulation	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCC(=O)O)NC1=O	10.1021/jm0510326
	164626394	186567	0	None	-5	3	Mouse	5.6	pEC50	=	5.6	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	594	11	3	3	6.5	CCC[C@@H]1CN([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C(=N)N1CC12CC3CC(CC(C3)C1)C2	10.1021/acs.jmedchem.0c02041
	CHEMBL4878558	186567	0	None	-5	3	Mouse	5.6	pEC50	=	5.6	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	594	11	3	3	6.5	CCC[C@@H]1CN([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C(=N)N1CC12CC3CC(CC(C3)C1)C2	10.1021/acs.jmedchem.0c02041
	45487406	196871	0	None	-24	4	Mouse	4.6	pEC50	=	4.6	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL	605	16	8	6	0.3	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccccc1F)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL566150	196871	0	None	-24	4	Mouse	4.6	pEC50	=	4.6	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL	605	16	8	6	0.3	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccccc1F)C(N)=O	10.1016/j.bmcl.2009.07.025
	137659790	159298	0	None	-11	4	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL	1728	21	21	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL4099889	159298	0	None	-11	4	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL	1728	21	21	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	44413829	78037	0	None	-10	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	584	12	5	5	3.5	N=C(N)NCCC[C@H]1C[C@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCCCN1	10.1021/jm060384p
	CHEMBL210011	78037	0	None	-10	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	584	12	5	5	3.5	N=C(N)NCCC[C@H]1C[C@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCCCN1	10.1021/jm060384p
	44445082	154278	0	None	6	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL	799	9	10	8	0.2	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)CCCNCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL398664	154278	0	None	6	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL	799	9	10	8	0.2	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)CCCNCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	162672255	182847	0	None	-1	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1100	18	14	11	0.6	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4791788	182847	0	None	-1	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1100	18	14	11	0.6	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	44310344	97300	0	None	-186	4	Mouse	7.5	pEC50	=	7.5	Functional	Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor	ChEMBL	4414	53	53	68	-9.9	CC(=O)NN[C@H]1CSSSSC[C@@H]2NC(=O)[C@@H]3CSSSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)C(N)=O)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@@H]4CSSSSC[C@H](NC(=O)[C@H](Cc5ccc(O)cc5)NC(=O)[C@H](CSSSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc5c[nH]cn5)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C(C)C)NC1=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N3)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC2=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NN(Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N4	10.1021/jm0303608
	77231883	97300	0	None	-186	4	Mouse	7.5	pEC50	=	7.5	Functional	Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor	ChEMBL	4414	53	53	68	-9.9	CC(=O)NN[C@H]1CSSSSC[C@@H]2NC(=O)[C@@H]3CSSSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)C(N)=O)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@@H]4CSSSSC[C@H](NC(=O)[C@H](Cc5ccc(O)cc5)NC(=O)[C@H](CSSSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc5c[nH]cn5)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C(C)C)NC1=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N3)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC2=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NN(Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N4	10.1021/jm0303608
	CHEMBL269274	97300	0	None	-186	4	Mouse	7.5	pEC50	=	7.5	Functional	Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor	ChEMBL	4414	53	53	68	-9.9	CC(=O)NN[C@H]1CSSSSC[C@@H]2NC(=O)[C@@H]3CSSSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)C(N)=O)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@@H]4CSSSSC[C@H](NC(=O)[C@H](Cc5ccc(O)cc5)NC(=O)[C@H](CSSSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc5c[nH]cn5)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C(C)C)NC1=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N3)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC2=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NN(Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N4	10.1021/jm0303608
	137656521	159720	0	None	-12	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1139	22	17	16	-3.1	CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	CHEMBL4104927	159720	0	None	-12	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1139	22	17	16	-3.1	CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	44391927	13959	0	None	-57	3	Human	5.5	pEC50	=	5.5	Functional	Effective concentration towards human melanocortin-3 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-3 receptor mediated cAMP accumulation in CHO cells	ChEMBL	557	7	3	5	2.9	CN1CCNC[C@H]1C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(=O)NC(C)(C)C)(C2CCCCC2)CC1	10.1016/j.bmcl.2004.10.020
	CHEMBL1196971	13959	0	None	-57	3	Human	5.5	pEC50	=	5.5	Functional	Effective concentration towards human melanocortin-3 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-3 receptor mediated cAMP accumulation in CHO cells	ChEMBL	557	7	3	5	2.9	CN1CCNC[C@H]1C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(=O)NC(C)(C)C)(C2CCCCC2)CC1	10.1016/j.bmcl.2004.10.020
	CHEMBL3216393	13959	0	None	-57	3	Human	5.5	pEC50	=	5.5	Functional	Effective concentration towards human melanocortin-3 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-3 receptor mediated cAMP accumulation in CHO cells	ChEMBL	557	7	3	5	2.9	CN1CCNC[C@H]1C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(=O)NC(C)(C)C)(C2CCCCC2)CC1	10.1016/j.bmcl.2004.10.020
	168296647	192451	0	None	-158	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1319	15	14	15	0.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSCc2ccccc2CSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5208830	192451	0	None	-158	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1319	15	14	15	0.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSCc2ccccc2CSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	44441648	154667	0	None	-41	3	Human	5.5	pEC50	=	5.5	Functional	Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production	ChEMBL	605	8	2	8	2.9	Cn1nnnc1CC1(C2CCOCC2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL399715	154667	0	None	-41	3	Human	5.5	pEC50	=	5.5	Functional	Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production	ChEMBL	605	8	2	8	2.9	Cn1nnnc1CC1(C2CCOCC2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	44413842	138352	0	None	-5	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	587	14	5	6	1.3	NC(=O)C[C@H](N)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL377210	138352	0	None	-5	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	587	14	5	6	1.3	NC(=O)C[C@H](N)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N	10.1021/jm060384p
	44394624	96987	0	None	-60	3	Human	8.5	pEC50	=	8.5	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	964	27	11	9	2.4	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCCC(=O)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL266665	96987	0	None	-60	3	Human	8.5	pEC50	=	8.5	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	964	27	11	9	2.4	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCCC(=O)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL410404	212796	0	None	-25	5	Rat	8.5	pEC50	=	8.5	Functional	Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R)	ChEMBL		None	None	None		C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O	10.1021/jm030452x
	1323	2669	55	None	-58	8	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysisAgonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysis	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01848
	92432	2669	55	None	-58	8	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysisAgonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysis	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01848
	CHEMBL430239	2669	55	None	-58	8	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysisAgonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysis	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01848
	118722935	116210	0	None	-1	4	Mouse	8.5	pEC50	=	8.5	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cc2cn(nn2)CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL3358543	116210	0	None	-1	4	Mouse	8.5	pEC50	=	8.5	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cc2cn(nn2)CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	145966716	164281	0	None	18	4	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	887	11	12	9	-0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4212209	164281	0	None	18	4	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	887	11	12	9	-0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	118722925	116203	0	None	-4	4	Mouse	8.5	pEC50	=	8.5	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1052	34	13	11	1.6	CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=[N+]=[N-])C(N)=O	10.1021/jm501027w
	CHEMBL3358534	116203	0	None	-4	4	Mouse	8.5	pEC50	=	8.5	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1052	34	13	11	1.6	CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=[N+]=[N-])C(N)=O	10.1021/jm501027w
	CHEMBL5094168	215456	0	None	-42	4	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	118722929	116206	0	None	-4	4	Mouse	8.4	pEC50	=	8.4	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1052	34	13	11	1.6	CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O	10.1021/jm501027w
	CHEMBL3358538	116206	0	None	-4	4	Mouse	8.4	pEC50	=	8.4	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1052	34	13	11	1.6	CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O	10.1021/jm501027w
	118722939	116214	0	None	-6	4	Mouse	8.4	pEC50	=	8.4	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCCn2cc(nn2)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	CHEMBL3358547	116214	0	None	-6	4	Mouse	8.4	pEC50	=	8.4	Functional	Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay	ChEMBL	1048	17	13	13	-0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCCn2cc(nn2)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm501027w
	1334	1489	7	None	1	4	Human	8.4	pEC50	=	8.4	Functional	Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.	ChEMBL		None	None	None		None	10.1021/jm030119t
	16133814	1489	7	None	1	4	Human	8.4	pEC50	=	8.4	Functional	Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.	ChEMBL		None	None	None		None	10.1021/jm030119t
	CHEMBL437050	1489	7	None	1	4	Human	8.4	pEC50	=	8.4	Functional	Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.	ChEMBL		None	None	None		None	10.1021/jm030119t
	133053557	163682	0	None	6	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	851	11	12	9	-1.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4204975	163682	0	None	6	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	851	11	12	9	-1.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	155542040	173054	0	None	-151	4	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	654	14	7	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4519837	173054	0	None	-151	4	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	654	14	7	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	137633806	156457	0	None	-10	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1031	14	14	13	-2.0	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CSSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC1=O	10.1021/acs.jmedchem.7b00353
	CHEMBL4067491	156457	0	None	-10	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1031	14	14	13	-2.0	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CSSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](C)NC1=O	10.1021/acs.jmedchem.7b00353
	127047913	139899	0	None	-7	5	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	962	35	12	13	-1.5	N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)COCC(=O)NCCCOCCOCCOCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL3799563	139899	0	None	-7	5	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	962	35	12	13	-1.5	N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)COCC(=O)NCCCOCCOCCOCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL380638	212248	0	None	-3	3	Human	6.5	pEC50	=	6.5	Functional	Activity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulation	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCC)NC1=O	10.1021/jm0510326
	25128748	189967	0	None	-8	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	490	7	2	4	2.3	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](C)C1=O	10.1021/jm800525p
	CHEMBL517108	189967	0	None	-8	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	490	7	2	4	2.3	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](C)C1=O	10.1021/jm800525p
	137656180	159004	0	None	-144	4	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	1005	12	12	11	-2.0	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.6b01707
	CHEMBL4096678	159004	0	None	-144	4	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	1005	12	12	11	-2.0	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.6b01707
	CHEMBL413439	213047	0	None	-40	4	Human	6.5	pEC50	=	6.5	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm049579s
	44322924	107085	0	None	-42	3	Human	6.5	pEC50	=	6.5	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	701	19	11	8	-1.4	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL316038	107085	0	None	-42	3	Human	6.5	pEC50	=	6.5	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	701	19	11	8	-1.4	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	137638218	156804	0	None	-66	4	Mouse	5.5	pEC50	=	5.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	988	11	11	10	-0.7	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.6b01707
	CHEMBL4071283	156804	0	None	-66	4	Mouse	5.5	pEC50	=	5.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	988	11	11	10	-0.7	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.6b01707
	137657607	159612	0	None	-56	3	Mouse	5.5	pEC50	=	5.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	844	15	7	6	2.4	CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4103567	159612	0	None	-56	3	Mouse	5.5	pEC50	=	5.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	844	15	7	6	2.4	CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	155547842	173672	0	None	-125	4	Mouse	5.5	pEC50	=	5.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	741	17	10	7	-1.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4535510	173672	0	None	-125	4	Mouse	5.5	pEC50	=	5.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	741	17	10	7	-1.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL3287060	211276	0	None	-52	5	Mouse	5.5	pEC50	=	5.5	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.9b00198
	155554827	174595	0	None	-8	3	Mouse	4.5	pEC50	=	4.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	621	16	8	7	-1.6	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4557656	174595	0	None	-8	3	Mouse	4.5	pEC50	=	4.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	621	16	8	7	-1.6	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	45487410	197415	0	None	-97	4	Mouse	4.5	pEC50	=	4.5	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL	655	16	8	6	1.1	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1cccc(C(F)(F)F)c1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL569696	197415	0	None	-97	4	Mouse	4.5	pEC50	=	4.5	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL	655	16	8	6	1.1	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1cccc(C(F)(F)F)c1)C(N)=O	10.1016/j.bmcl.2009.07.025
	44394659	66924	0	None	-288	3	Human	5.5	pEC50	=	5.5	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	754	19	9	7	1.5	N#CCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL186687	66924	0	None	-288	3	Human	5.5	pEC50	=	5.5	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	754	19	9	7	1.5	N#CCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	46885712	8039	0	None	-169	4	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	488	3	1	3	4.9	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)cc1	10.1021/jm9017866
	CHEMBL1091151	8039	0	None	-169	4	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	488	3	1	3	4.9	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)cc1	10.1021/jm9017866
	CHEMBL1204061	8039	0	None	-169	4	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	488	3	1	3	4.9	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(F)cc1	10.1021/jm9017866
	44457021	97873	0	None	-17	3	Mouse	4.5	pEC50	=	4.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	ChEMBL	399	6	4	3	2.2	N=C(N)NCCCC1NC(=O)c2ccc(Cl)cc2N(Cc2ccccc2)C1=O	10.1021/jm701303z
	CHEMBL272439	97873	0	None	-17	3	Mouse	4.5	pEC50	=	4.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	ChEMBL	399	6	4	3	2.2	N=C(N)NCCCC1NC(=O)c2ccc(Cl)cc2N(Cc2ccccc2)C1=O	10.1021/jm701303z
	CHEMBL185869	209030	0	None	-89	3	Human	5.5	pEC50	=	5.5	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		CCOC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL2369485	209605	0	None	-5	4	Mouse	6.5	pEC50	=	6.5	Functional	Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NN[C@H]2Cc3ccc(O)cc3NC2=O)CC(=O)N[C@H](C(=O)NN[C@@H](Cc2ccc(O)cc2)C(=O)C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm0303608
	137641398	158292	0	None	-416	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1694	20	20	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4089162	158292	0	None	-416	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1694	20	20	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL264190	210585	1	None	-35	8	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.0c02041
	CHEMBL411378	212858	0	None	-56	5	Rat	7.5	pEC50	=	7.5	Functional	Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R)	ChEMBL		None	None	None		Cc1nc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)CSSC[C@H](C(=O)N[C@H](C(N)=O)[C@@H](C)O)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc3ccccc3)NC2=O)c[nH]1	10.1021/jm030452x
	164623182	185595	0	None	1	2	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	607	11	4	4	5.4	CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H]([C@@H](C)O)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4864094	185595	0	None	1	2	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	607	11	4	4	5.4	CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H]([C@@H](C)O)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	44413938	138914	0	None	-15	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	662	15	4	5	3.9	CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL378446	138914	0	None	-15	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	662	15	4	5	3.9	CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	44394691	122877	0	None	-15	3	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	792	19	9	7	2.2	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1cccnc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL360598	122877	0	None	-15	3	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	792	19	9	7	2.2	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1cccnc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	145988867	167079	0	None	-4	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assayAgonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assay	ChEMBL	660	17	7	6	1.7	CCCC[C@H](NC(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	CHEMBL4289983	167079	0	None	-4	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assayAgonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assay	ChEMBL	660	17	7	6	1.7	CCCC[C@H](NC(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	44413831	78035	0	None	-6	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	632	12	5	5	4.0	N=C(N)NCCC[C@@H]1C[C@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1Cc2ccccc2CN1	10.1021/jm060384p
	CHEMBL210008	78035	0	None	-6	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	632	12	5	5	4.0	N=C(N)NCCC[C@@H]1C[C@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1Cc2ccccc2CN1	10.1021/jm060384p
	134466953	156634	0	None	-91	4	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	1153	14	13	12	-1.3	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.6b01707
	CHEMBL4069451	156634	0	None	-91	4	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	1153	14	13	12	-1.3	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.6b01707
	24882615	97464	0	None	-6	4	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	ChEMBL	371	6	2	3	3.1	NCCCCC1NC(=O)c2ccc(Cl)cc2N(Cc2ccccc2)C1=O	10.1021/jm701303z
	CHEMBL270270	97464	0	None	-6	4	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	ChEMBL	371	6	2	3	3.1	NCCCCC1NC(=O)c2ccc(Cl)cc2N(Cc2ccccc2)C1=O	10.1021/jm701303z
	51351024	58772	0	None	-13	4	Mouse	5.5	pEC50	=	5.5	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N2C[C@@H](Cc3ccccc3)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	53318435	58772	0	None	-13	4	Mouse	5.5	pEC50	=	5.5	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N2C[C@@H](Cc3ccccc3)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	91932358	58772	0	None	-13	4	Mouse	5.5	pEC50	=	5.5	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N2C[C@@H](Cc3ccccc3)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	CHEMBL1688106	58772	0	None	-13	4	Mouse	5.5	pEC50	=	5.5	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N2C[C@@H](Cc3ccccc3)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	102096778	58776	0	None	-35	4	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	51351277	58776	0	None	-35	4	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	53322400	58776	0	None	-35	4	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	91932360	58776	0	None	-35	4	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	CHEMBL1688111	58776	0	None	-35	4	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	122184910	122529	0	None	-30	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3601428	122529	0	None	-30	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	145977650	163810	0	None	2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	865	11	12	9	-0.7	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4206406	163810	0	None	2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	865	11	12	9	-0.7	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	1323	2669	55	None	-58	8	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00353
	92432	2669	55	None	-58	8	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00353
	CHEMBL430239	2669	55	None	-58	8	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00353
	44577519	188745	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	904	12	10	11	1.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC1=O	10.1021/jm701181n
	CHEMBL505536	188745	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	904	12	10	11	1.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC1=O	10.1021/jm701181n
	45487409	196874	0	None	-51	4	Mouse	4.5	pEC50	=	4.5	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL	621	16	8	6	0.8	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1cccc(Cl)c1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL566162	196874	0	None	-51	4	Mouse	4.5	pEC50	=	4.5	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL	621	16	8	6	0.8	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1cccc(Cl)c1)C(N)=O	10.1016/j.bmcl.2009.07.025
	44394783	126347	0	None	1	3	Human	7.5	pEC50	=	7.5	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	847	23	9	6	4.0	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CCCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL365044	126347	0	None	1	3	Human	7.5	pEC50	=	7.5	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	847	23	9	6	4.0	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CCCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	16157270	212530	14	None	-22	7	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/acs.jmedchem.5b01894
	CHEMBL405282	212530	14	None	-22	7	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/acs.jmedchem.5b01894
	44413879	138877	0	None	-112	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	681	15	6	7	0.9	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1C(=O)NCCN=C(N)N	10.1021/jm060384p
	CHEMBL378293	138877	0	None	-112	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	681	15	6	7	0.9	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1C(=O)NCCN=C(N)N	10.1021/jm060384p
	CHEMBL105113	208443	0	None	-30	4	Mouse	4.5	pEC50	=	4.5	Functional	Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	90643802	111715	0	None	-41	5	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL	820	14	5	8	1.9	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O	10.1021/jm500064t
	CHEMBL3287322	111715	0	None	-41	5	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL	820	14	5	8	1.9	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O	10.1021/jm500064t
	CHEMBL3349030	211382	0	None	1	3	Human	7.5	pEC50	=	7.5	Functional	Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorEffective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	155547310	173587	0	None	-6	3	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	750	17	7	7	0.5	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4533593	173587	0	None	-6	3	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	750	17	7	7	0.5	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	164621263	185458	0	None	1	2	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	598	11	3	3	7.2	CCC[C@@H]1CN([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C(=N)N1CC1CCC(C(C)(C)C)CC1	10.1021/acs.jmedchem.0c02041
	CHEMBL4862172	185458	0	None	1	2	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	598	11	3	3	7.2	CCC[C@@H]1CN([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C(=N)N1CC1CCC(C(C)(C)C)CC1	10.1021/acs.jmedchem.0c02041
	CHEMBL89270	215876	0	None	-11	3	Human	6.5	pEC50	=	6.5	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL		None	None	None		NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]cn1	10.1016/s0960-894x(03)00552-3
	11753695	8361	7	None	-281	8	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MC3R expressed in CHO cells assessed as stimulation of intracellular cAMP accumulationAgonist activity at human MC3R expressed in CHO cells assessed as stimulation of intracellular cAMP accumulation	ChEMBL	599	4	1	3	6.7	CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21	10.1016/j.bmcl.2010.02.058
	CHEMBL1093304	8361	7	None	-281	8	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MC3R expressed in CHO cells assessed as stimulation of intracellular cAMP accumulationAgonist activity at human MC3R expressed in CHO cells assessed as stimulation of intracellular cAMP accumulation	ChEMBL	599	4	1	3	6.7	CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21	10.1016/j.bmcl.2010.02.058
	162670795	182802	0	None	-21	3	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	696	15	7	6	1.7	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C	10.1021/acsmedchemlett.0c00561
	CHEMBL4791112	182802	0	None	-21	3	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	696	15	7	6	1.7	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C	10.1021/acsmedchemlett.0c00561
	CHEMBL410168	212781	0	None	-4	3	Human	7.4	pEC50	=	7.4	Functional	Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H]1CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC1=O	10.1021/jm030119t
	164624627	185855	0	None	-2	4	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	589	10	4	4	4.4	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H]([C@@H](C)O)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4868223	185855	0	None	-2	4	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	589	10	4	4	4.4	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H]([C@@H](C)O)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	164627764	186540	0	None	2	2	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	603	11	4	4	4.8	CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H]([C@@H](C)O)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4878201	186540	0	None	2	2	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	603	11	4	4	4.8	CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H]([C@@H](C)O)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	46885523	7771	0	None	-512	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	493	4	1	6	3.4	C[C@H]1CN(C(=O)[C@H]2CN(c3cccnn3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccn1	10.1021/jm9017866
	CHEMBL1089461	7771	0	None	-512	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	493	4	1	6	3.4	C[C@H]1CN(C(=O)[C@H]2CN(c3cccnn3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccn1	10.1021/jm9017866
	46885711	8038	0	None	-123	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	504	3	1	3	5.4	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(Cl)cc1	10.1021/jm9017866
	CHEMBL1091150	8038	0	None	-123	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	504	3	1	3	5.4	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccc(Cl)cc1	10.1021/jm9017866
	CHEMBL446185	213921	0	None	-1	3	Human	7.4	pEC50	=	7.4	Functional	Activity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulation	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm0510326
	44415912	139201	0	None	-23	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	575	11	4	5	1.3	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL378837	139201	0	None	-23	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	575	11	4	5	1.3	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	44408287	75357	0	None	-218	4	Human	6.4	pEC50	=	6.4	Functional	Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation	ChEMBL	620	8	2	5	5.1	C[C@@H]1COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.11.095
	CHEMBL203911	75357	0	None	-218	4	Human	6.4	pEC50	=	6.4	Functional	Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation	ChEMBL	620	8	2	5	5.1	C[C@@H]1COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.11.095
	CHEMBL2371962	210136	0	None	-1412	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MC3R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC3R expressed in CHO cells assessed as cAMP accumulation	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2C(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm0614275
	164609130	184403	0	None	-1	3	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	595	10	4	4	5.1	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H]([C@@H](C)O)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4846261	184403	0	None	-1	3	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	595	10	4	4	5.1	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H]([C@@H](C)O)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	164615813	185120	0	None	-12	3	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	594	10	3	3	6.4	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H](C(C)C)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4856877	185120	0	None	-12	3	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	594	10	3	3	6.4	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H](C(C)C)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	11845804	79529	0	None	-467	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	652	15	5	6	2.6	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL211419	79529	0	None	-467	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	652	15	5	6	2.6	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL264190	210585	1	None	-35	8	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayAgonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.5b00053
	CHEMBL5094215	215458	0	None	-46	4	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](C)C(=O)N2	10.1021/acs.jmedchem.1c00095
	168285904	191646	0	None	-234	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1347	15	14	15	1.3	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSCc2cccc(c2)CSCC[C@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5196407	191646	0	None	-234	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1347	15	14	15	1.3	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSCc2cccc(c2)CSCC[C@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	162654633	180620	0	None	-43	3	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	734	16	8	7	1.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	CHEMBL4754987	180620	0	None	-43	3	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	734	16	8	7	1.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	CHEMBL263878	210575	0	None	2	3	Human	7.4	pEC50	=	7.4	Functional	Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@@H]1CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC1=O	10.1021/jm030119t
	168290510	191873	0	None	-4	4	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1215	15	14	15	-1.3	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5199932	191873	0	None	-4	4	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1215	15	14	15	-1.3	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5085972	214980	0	None	-4	4	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.1c00095
	CHEMBL91957	215882	0	None	-35	3	Human	6.4	pEC50	=	6.4	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL		None	None	None		N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NS(=O)(=O)c1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	137659091	159316	0	None	-41	3	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	806	12	6	6	1.5	CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4100160	159316	0	None	-41	3	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	806	12	6	6	1.5	CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	51350673	58770	0	None	-20	4	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)N2C[C@H](Cc3cnc[nH]3)NC(=O)[C@H](CSCC2=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	53317148	58770	0	None	-20	4	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)N2C[C@H](Cc3cnc[nH]3)NC(=O)[C@H](CSCC2=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	91932362	58770	0	None	-20	4	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)N2C[C@H](Cc3cnc[nH]3)NC(=O)[C@H](CSCC2=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	CHEMBL1688104	58770	0	None	-20	4	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)N2C[C@H](Cc3cnc[nH]3)NC(=O)[C@H](CSCC2=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	122184909	122528	0	None	-13	4	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3601427	122528	0	None	-13	4	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL5077811	214493	0	None	-72	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CC(=O)N[C@H]1CSSC[C@@H](C(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c00095
	155553683	174159	0	None	-13	4	Mouse	8.4	pEC50	=	8.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	746	14	7	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4547556	174159	0	None	-13	4	Mouse	8.4	pEC50	=	8.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	746	14	7	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL5080489	214666	0	None	-4	4	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N2	10.1021/acs.jmedchem.1c00095
	145976863	163734	0	None	1	4	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	879	11	12	9	-0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4205548	163734	0	None	1	4	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	879	11	12	9	-0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	1324	301	25	None	-15	9	Human	8.4	pEC50	=	8.4	Functional	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm960845e
	16154396	301	25	None	-15	9	Human	8.4	pEC50	=	8.4	Functional	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm960845e
	16197727	301	25	None	-15	9	Human	8.4	pEC50	=	8.4	Functional	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm960845e
	44285019	301	25	None	-15	9	Human	8.4	pEC50	=	8.4	Functional	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm960845e
	57514683	301	25	None	-15	9	Human	8.4	pEC50	=	8.4	Functional	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm960845e
	91898441	301	25	None	-15	9	Human	8.4	pEC50	=	8.4	Functional	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm960845e
	CHEMBL441738	301	25	None	-15	9	Human	8.4	pEC50	=	8.4	Functional	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm960845e
	DB04931	301	25	None	-15	9	Human	8.4	pEC50	=	8.4	Functional	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm960845e
	1324	301	25	None	-15	9	Human	8.4	pEC50	=	8.4	Functional	effective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 3 receptoreffective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm960840h
	16154396	301	25	None	-15	9	Human	8.4	pEC50	=	8.4	Functional	effective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 3 receptoreffective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm960840h
	16197727	301	25	None	-15	9	Human	8.4	pEC50	=	8.4	Functional	effective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 3 receptoreffective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm960840h
	44285019	301	25	None	-15	9	Human	8.4	pEC50	=	8.4	Functional	effective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 3 receptoreffective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm960840h
	57514683	301	25	None	-15	9	Human	8.4	pEC50	=	8.4	Functional	effective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 3 receptoreffective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm960840h
	91898441	301	25	None	-15	9	Human	8.4	pEC50	=	8.4	Functional	effective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 3 receptoreffective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm960840h
	CHEMBL441738	301	25	None	-15	9	Human	8.4	pEC50	=	8.4	Functional	effective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 3 receptoreffective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm960840h
	DB04931	301	25	None	-15	9	Human	8.4	pEC50	=	8.4	Functional	effective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 3 receptoreffective concentration of peptide at 50% maximal cAMP accumulation on Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm960840h
	CHEMBL439128	213802	0	None	-1	3	Human	8.4	pEC50	=	8.4	Functional	Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@@H]1CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC1=O	10.1021/jm030119t
	44394623	141513	0	None	-1	2	Human	8.3	pEC50	=	8.3	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	936	26	11	8	2.4	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL384720	141513	0	None	-1	2	Human	8.3	pEC50	=	8.3	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	936	26	11	8	2.4	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	44322896	167948	0	None	-1	2	Human	8.3	pEC50	=	8.3	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	789	22	10	7	1.6	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL431801	167948	0	None	-1	2	Human	8.3	pEC50	=	8.3	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	789	22	10	7	1.6	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	25133210	169433	0	None	-44	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	615	11	3	5	3.0	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@@H]1CCCN1	10.1021/jm800525p
	CHEMBL442829	169433	0	None	-44	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	615	11	3	5	3.0	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@@H]1CCCN1	10.1021/jm800525p
	134463477	159228	0	None	-131	4	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	977	11	12	11	-1.9	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.6b01707
	CHEMBL4099127	159228	0	None	-131	4	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	977	11	12	11	-1.9	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.6b01707
	132180597	156147	0	None	-275	4	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	784	15	8	7	-0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4063911	156147	0	None	-275	4	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	784	15	8	7	-0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	155550083	173890	0	None	-13	4	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	775	16	8	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4540411	173890	0	None	-13	4	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	775	16	8	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	155556466	174392	0	None	-56	4	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	648	17	8	6	1.2	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4552764	174392	0	None	-56	4	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	648	17	8	6	1.2	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	162666503	182206	0	None	-36	3	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	696	15	7	6	1.7	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C	10.1021/acsmedchemlett.0c00561
	CHEMBL4783292	182206	0	None	-36	3	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	696	15	7	6	1.7	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O)C(C)C	10.1021/acsmedchemlett.0c00561
	44322787	105937	0	None	-6	3	Human	7.4	pEC50	=	7.4	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	791	21	11	8	0.2	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)C(O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL312998	105937	0	None	-6	3	Human	7.4	pEC50	=	7.4	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	791	21	11	8	0.2	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)C(O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	162669632	182541	0	None	1	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3ccc4ccccc4c3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4787753	182541	0	None	1	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3ccc4ccccc4c3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL409049	212722	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@H]1C(=O)NCC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)CSSC1(C)C	10.1021/jm030119t
	137646802	157927	0	None	-19	2	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	888	18	8	7	3.4	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4084671	157927	0	None	-19	2	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	888	18	8	7	3.4	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	155531140	171594	0	None	-13	4	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	666	16	8	7	0.3	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.9b00198
	CHEMBL4465466	171594	0	None	-13	4	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	666	16	8	7	0.3	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.9b00198
	164621924	185927	0	None	-6	3	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	587	10	3	3	5.7	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H](C(C)C)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4869531	185927	0	None	-6	3	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	587	10	3	3	5.7	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H](C(C)C)N(CC23CC4CC(CC(C4)C2)C3)C1=N	10.1021/acs.jmedchem.0c02041
	44347927	157252	0	None	-1	3	Human	6.4	pEC50	=	6.4	Functional	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL	1443	31	14	21	-1.9	CC(=O)[C@@H]1CSSC[C@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	CHEMBL407680	157252	0	None	-1	3	Human	6.4	pEC50	=	6.4	Functional	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL	1443	31	14	21	-1.9	CC(=O)[C@@H]1CSSC[C@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	CHEMBL2323788	209491	0	None	-75	4	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	16007263	79767	0	None	-23	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	557	11	4	5	1.2	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccccc2)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL211975	79767	0	None	-23	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	557	11	4	5	1.2	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccccc2)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	44394784	126269	0	None	-1	3	Human	7.4	pEC50	=	7.4	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	861	23	9	7	3.6	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CCCC(=O)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL365019	126269	0	None	-1	3	Human	7.4	pEC50	=	7.4	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	861	23	9	7	3.6	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CCCC(=O)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL321870	211209	0	None	-79	4	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	46885526	7732	0	None	-51	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	456	4	1	5	3.2	C[C@H]1CN(C(=O)[C@H]2CN(c3cccnn3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)C1CC1	10.1021/jm9017866
	CHEMBL1089135	7732	0	None	-51	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	456	4	1	5	3.2	C[C@H]1CN(C(=O)[C@H]2CN(c3cccnn3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)C1CC1	10.1021/jm9017866
	CHEMBL1204056	7732	0	None	-51	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	456	4	1	5	3.2	C[C@H]1CN(C(=O)[C@H]2CN(c3cccnn3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)C1CC1	10.1021/jm9017866
	122179552	121461	0	None	-74	4	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayAgonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	ChEMBL	699	19	10	7	0.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CC(N)=O)Cc1c[nH]c2ccccc12	10.1021/acsmedchemlett.5b00053
	CHEMBL3582446	121461	0	None	-74	4	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayAgonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	ChEMBL	699	19	10	7	0.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CC(N)=O)Cc1c[nH]c2ccccc12	10.1021/acsmedchemlett.5b00053
	44456957	98010	0	None	-18	3	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	ChEMBL	432	5	1	2	5.2	O=C1NC(Cc2ccccc2)C(=O)N(Cc2ccccc2-c2ccccc2)c2ccccc21	10.1021/jm701303z
	CHEMBL273044	98010	0	None	-18	3	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay	ChEMBL	432	5	1	2	5.2	O=C1NC(Cc2ccccc2)C(=O)N(Cc2ccccc2-c2ccccc2)c2ccccc21	10.1021/jm701303z
	44413931	77986	0	None	-9	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	643	16	5	6	1.9	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL209789	77986	0	None	-9	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	643	16	5	6	1.9	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	145948876	167459	0	None	5	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMXAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMX	ChEMBL	1220	17	14	11	1.9	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2CCCN2C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.5b01285
	CHEMBL4299441	167459	0	None	5	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMXAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMX	ChEMBL	1220	17	14	11	1.9	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2CCCN2C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.5b01285
	CHEMBL3349030	211382	0	None	1	3	Human	7.4	pEC50	=	7.4	Functional	Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorEffective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	164624386	186174	0	None	1	3	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	593	10	4	4	5.0	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H]([C@@H](C)O)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4872932	186174	0	None	1	3	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	593	10	4	4	5.0	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H]([C@@H](C)O)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	44394693	96569	0	None	-2	3	Human	7.4	pEC50	=	7.4	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	805	20	9	6	2.8	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL263234	96569	0	None	-2	3	Human	7.4	pEC50	=	7.4	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	805	20	9	6	2.8	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL382369	212282	0	None	1	2	Human	5.4	pEC50	=	5.4	Functional	Activity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulation	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm0510326
	164627732	186470	0	None	-14	3	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	598	10	3	3	7.0	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H](C(C)C)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	CHEMBL4877232	186470	0	None	-14	3	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	598	10	3	3	7.0	CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H](C(C)C)N(CC2CCC(C(C)(C)C)CC2)C1=N	10.1021/acs.jmedchem.0c02041
	44441647	154666	0	None	-18	3	Human	6.4	pEC50	=	6.4	Functional	Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production	ChEMBL	631	8	2	7	4.1	Cn1nnnc1CC1(c2ccc(Cl)cc2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL399714	154666	0	None	-18	3	Human	6.4	pEC50	=	6.4	Functional	Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production	ChEMBL	631	8	2	7	4.1	Cn1nnnc1CC1(c2ccc(Cl)cc2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	168278924	191042	0	None	-22	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysisAgonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysis	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2cccc(c2)CSC(C)(C)[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	CHEMBL5187368	191042	0	None	-22	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysisAgonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysis	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2cccc(c2)CSC(C)(C)[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	CHEMBL50056	214096	2	None	-138	7	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	CHEMBL50056	214096	2	None	-138	7	Mouse	5.4	pEC50	=	5.4	Functional	Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010061n
	45487404	197413	0	None	-8709	5	Mouse	4.4	pEC50	=	4.4	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL	603	18	8	6	0.4	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCCc1ccccc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL569694	197413	0	None	-8709	5	Mouse	4.4	pEC50	=	4.4	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL	603	18	8	6	0.4	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCCc1ccccc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	44569176	172521	0	None	-48	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	629	11	3	5	3.3	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@H]1CCCCN1	10.1021/jm800525p
	CHEMBL448410	172521	0	None	-48	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	629	11	3	5	3.3	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@H]1CCCCN1	10.1021/jm800525p
	25129107	173753	0	None	-36	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	603	11	3	5	2.9	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C(C)(C)N	10.1021/jm800525p
	CHEMBL453734	173753	0	None	-36	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	603	11	3	5	2.9	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C(C)(C)N	10.1021/jm800525p
	11181928	166133	0	None	-13	4	Mouse	7.4	pEC50	=	7.4	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL	797	26	9	7	2.5	CCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL426282	166133	0	None	-13	4	Mouse	7.4	pEC50	=	7.4	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL	797	26	9	7	2.5	CCCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	155561730	175629	0	None	-144	3	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	684	14	7	6	-0.3	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4581269	175629	0	None	-144	3	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	684	14	7	6	-0.3	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	44305956	102734	0	None	-1	4	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cellsAgonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells	ChEMBL	490	11	5	4	2.9	NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NC1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(03)00318-4
	CHEMBL305132	102734	0	None	-1	4	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cellsAgonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells	ChEMBL	490	11	5	4	2.9	NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NC1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(03)00318-4
	44305784	203316	0	None	1	3	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cellsAgonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells	ChEMBL	447	8	4	3	3.4	CC1CCN(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)NCc2ccccc2)CC1	10.1016/s0960-894x(03)00318-4
	CHEMBL64967	203316	0	None	1	3	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cellsAgonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells	ChEMBL	447	8	4	3	3.4	CC1CCN(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)NCc2ccccc2)CC1	10.1016/s0960-894x(03)00318-4
	155550338	174284	0	None	-630	3	Mouse	4.4	pEC50	=	4.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	649	17	10	7	-1.6	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4550246	174284	0	None	-630	3	Mouse	4.4	pEC50	=	4.4	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	649	17	10	7	-1.6	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL317228	211177	0	None	-10	4	Mouse	4.4	pEC50	=	4.4	Functional	Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)c1ccccc1	10.1021/jm010524p
	CHEMBL184870	209028	0	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		C=CCNC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	44322959	156051	0	None	-22	3	Human	7.4	pEC50	=	7.4	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	727	21	9	7	0.6	CCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL406276	156051	0	None	-22	3	Human	7.4	pEC50	=	7.4	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	727	21	9	7	0.6	CCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	44408154	141337	0	None	-316	4	Human	6.4	pEC50	=	6.4	Functional	Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation	ChEMBL	668	8	2	5	5.1	CC1(C)CCN(CC2(C3CCCCC3)CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)S1(=O)=O	10.1016/j.bmcl.2005.11.095
	CHEMBL383719	141337	0	None	-316	4	Human	6.4	pEC50	=	6.4	Functional	Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation	ChEMBL	668	8	2	5	5.1	CC1(C)CCN(CC2(C3CCCCC3)CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)S1(=O)=O	10.1016/j.bmcl.2005.11.095
	44322788	157359	0	None	-58	3	Human	6.4	pEC50	=	6.4	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	699	19	9	7	-0.2	CCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL407825	157359	0	None	-58	3	Human	6.4	pEC50	=	6.4	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	699	19	9	7	-0.2	CCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL2323789	209492	0	None	-2290	4	Mouse	5.4	pEC50	=	5.4	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	44394690	124622	0	None	-14	3	Human	6.3	pEC50	=	6.3	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	792	19	9	7	2.2	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1ccccn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL364119	124622	0	None	-14	3	Human	6.3	pEC50	=	6.3	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	792	19	9	7	2.2	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1ccccn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	168285101	191620	0	None	-213	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1347	15	14	15	1.3	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSCc2ccccc2CSCC[C@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5195937	191620	0	None	-213	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1347	15	14	15	1.3	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSCc2ccccc2CSCC[C@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	46885760	8246	0	None	-102	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	506	3	1	3	5.1	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1c(F)cccc1F	10.1021/jm9017866
	CHEMBL1092550	8246	0	None	-102	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	506	3	1	3	5.1	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1c(F)cccc1F	10.1021/jm9017866
	137653916	158556	0	None	-18	4	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	828	18	9	8	1.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4091894	158556	0	None	-18	4	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	828	18	9	8	1.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	44394582	168350	0	None	-2	3	Human	6.3	pEC50	=	6.3	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	771	21	8	6	2.5	CCCCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL434544	168350	0	None	-2	3	Human	6.3	pEC50	=	6.3	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	771	21	8	6	2.5	CCCCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	102096778	58776	0	None	-35	4	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	51351277	58776	0	None	-35	4	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	53322400	58776	0	None	-35	4	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	91932360	58776	0	None	-35	4	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	CHEMBL1688111	58776	0	None	-35	4	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	CHEMBL3600840	211794	0	None	-1	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	137641157	157040	0	None	-131	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1666	20	22	21	-3.9	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4074074	157040	0	None	-131	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1666	20	22	21	-3.9	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	90643804	111717	0	None	-42	5	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL	839	16	7	8	1.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O	10.1021/jm500064t
	CHEMBL3287324	111717	0	None	-42	5	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL	839	16	7	8	1.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O	10.1021/jm500064t
	127046235	139613	0	None	-380	5	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	1004	36	12	13	-1.3	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL3797690	139613	0	None	-380	5	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	1004	36	12	13	-1.3	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(N)=O	10.1021/acs.jmedchem.5b01894
	44394581	122123	0	None	-12	3	Human	6.3	pEC50	=	6.3	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	755	19	9	6	1.9	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)C1CC1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL359702	122123	0	None	-12	3	Human	6.3	pEC50	=	6.3	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	755	19	9	6	1.9	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)C1CC1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL2323795	209498	0	None	-97	4	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccc(I)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	46885482	8298	0	None	-81	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	492	4	1	5	4.0	C[C@H]1CN(C(=O)[C@H]2CN(c3cccnn3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1	10.1021/jm9017866
	CHEMBL1092860	8298	0	None	-81	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	492	4	1	5	4.0	C[C@H]1CN(C(=O)[C@H]2CN(c3cccnn3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1	10.1021/jm9017866
	51351151	58775	0	None	-15	4	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	53318437	58775	0	None	-15	4	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	91932359	58775	0	None	-15	4	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	CHEMBL1688110	58775	0	None	-15	4	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	1635	23	20	21	-1.8	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm101425m
	44394580	122122	0	None	-4	3	Human	6.3	pEC50	=	6.3	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	757	19	8	6	2.0	CC(C)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL359701	122122	0	None	-4	3	Human	6.3	pEC50	=	6.3	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	757	19	8	6	2.0	CC(C)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	145972289	164496	0	None	27	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	915	11	12	9	0.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4214826	164496	0	None	27	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	915	11	12	9	0.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	1323	2669	55	None	-58	8	Human	8.3	pEC50	=	8.3	Functional	Activity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterActivity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counter	ChEMBL		None	None	None		None	10.1021/ml500436s
	92432	2669	55	None	-58	8	Human	8.3	pEC50	=	8.3	Functional	Activity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterActivity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counter	ChEMBL		None	None	None		None	10.1021/ml500436s
	CHEMBL430239	2669	55	None	-58	8	Human	8.3	pEC50	=	8.3	Functional	Activity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterActivity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counter	ChEMBL		None	None	None		None	10.1021/ml500436s
	137637283	155956	0	None	-15	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MC3R expressed in CHO cells assessed as increase in IBMX-induced cAMP accumulation after 40 minsAgonist activity at human MC3R expressed in CHO cells assessed as increase in IBMX-induced cAMP accumulation after 40 mins	ChEMBL	984	15	12	10	-0.5	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/acs.jmedchem.6b01707
	CHEMBL4061566	155956	0	None	-15	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MC3R expressed in CHO cells assessed as increase in IBMX-induced cAMP accumulation after 40 minsAgonist activity at human MC3R expressed in CHO cells assessed as increase in IBMX-induced cAMP accumulation after 40 mins	ChEMBL	984	15	12	10	-0.5	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/acs.jmedchem.6b01707
	1323	2669	55	None	-58	8	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assayAgonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assay	ChEMBL		None	None	None		None	10.1016/j.ejmech.2018.04.021
	92432	2669	55	None	-58	8	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assayAgonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assay	ChEMBL		None	None	None		None	10.1016/j.ejmech.2018.04.021
	CHEMBL430239	2669	55	None	-58	8	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assayAgonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assay	ChEMBL		None	None	None		None	10.1016/j.ejmech.2018.04.021
	1323	2669	55	None	-58	8	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC3R expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1016/j.bmcl.2011.03.019
	92432	2669	55	None	-58	8	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC3R expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1016/j.bmcl.2011.03.019
	CHEMBL430239	2669	55	None	-58	8	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC3R expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL		None	None	None		None	10.1016/j.bmcl.2011.03.019
	11158573	71090	0	None	-12	4	Mouse	8.3	pEC50	=	8.3	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL	783	25	9	7	2.1	CCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL195439	71090	0	None	-12	4	Mouse	8.3	pEC50	=	8.3	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL	783	25	9	7	2.1	CCCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL405791	212557	0	None	-1	4	Rat	8.3	pEC50	=	8.3	Functional	Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R)	ChEMBL		None	None	None		C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2ncc[nH]2)C(=O)N[C@H](Cc2cccc3ccccc23)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O	10.1021/jm030452x
	CHEMBL2372570	210248	0	None	-53	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC2=NC=NC2)NC1=O	10.1021/jm9017866
	44415920	80342	0	None	-3	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	644	12	4	6	1.2	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)N2CCNCC2)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL214410	80342	0	None	-3	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	644	12	4	6	1.2	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)N2CCNCC2)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	1334	1489	7	None	1	4	Human	8.2	pEC50	=	8.2	Functional	Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorEffective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm000211e
	16133814	1489	7	None	1	4	Human	8.2	pEC50	=	8.2	Functional	Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorEffective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm000211e
	CHEMBL437050	1489	7	None	1	4	Human	8.2	pEC50	=	8.2	Functional	Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorEffective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm000211e
	44577515	188983	0	None	2	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	943	12	11	11	1.6	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	CHEMBL508816	188983	0	None	2	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	943	12	11	11	1.6	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	155555182	174297	0	None	-20	3	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	778	18	9	7	0.5	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4550582	174297	0	None	-20	3	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	778	18	9	7	0.5	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	155561743	175748	0	None	-3	4	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	718	13	5	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4583714	175748	0	None	-3	4	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	718	13	5	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	155568641	176073	0	None	-83	4	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	654	14	7	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4591394	176073	0	None	-83	4	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	654	14	7	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	46885415	8247	0	None	-15	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	468	4	1	3	4.5	C[C@H]1CN(C(=O)[C@H]2CN(C3CCC3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1	10.1021/jm9017866
	CHEMBL1092571	8247	0	None	-15	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	468	4	1	3	4.5	C[C@H]1CN(C(=O)[C@H]2CN(C3CCC3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1	10.1021/jm9017866
	155566298	175769	0	None	-38	4	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	683	16	8	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4584189	175769	0	None	-38	4	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	683	16	8	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	137634306	156298	0	None	-1	2	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	822	18	9	7	0.9	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4065669	156298	0	None	-1	2	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	822	18	9	7	0.9	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.7b00301
	155554244	174925	0	None	-28	3	Mouse	4.3	pEC50	=	4.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	630	15	8	7	-0.9	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4565607	174925	0	None	-28	3	Mouse	4.3	pEC50	=	4.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	630	15	8	7	-0.9	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	168277543	190651	0	None	-125	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1347	15	14	15	1.3	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSCc2ccc(cc2)CSCC[C@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5181752	190651	0	None	-125	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayAgonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay	ChEMBL	1347	15	14	15	1.3	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSCc2ccc(cc2)CSCC[C@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	25129109	188678	0	None	-30	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	603	12	3	5	2.8	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@H](C)NC	10.1021/jm800525p
	CHEMBL504349	188678	0	None	-30	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	603	12	3	5	2.8	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@H](C)NC	10.1021/jm800525p
	132180653	175035	0	None	-51	3	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	784	15	8	7	-0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4567961	175035	0	None	-51	3	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	784	15	8	7	-0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	137648053	157515	0	None	-30	4	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	934	12	11	10	-1.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.6b01707
	CHEMBL4080169	157515	0	None	-30	4	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed by biotinylated cAMP addition and subsequent incubation for 2 hrs by AlphaScreen assay	ChEMBL	934	12	11	10	-1.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.6b01707
	122184911	122530	0	None	-10	4	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3601429	122530	0	None	-10	4	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	118735099	118773	0	None	-4	4	Human	7.3	pEC50	=	7.3	Functional	Activity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterActivity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counter	ChEMBL	746	15	9	6	1.6	CC(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN([C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	CHEMBL3421676	118773	0	None	-4	4	Human	7.3	pEC50	=	7.3	Functional	Activity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterActivity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counter	ChEMBL	746	15	9	6	1.6	CC(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN([C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	25133209	173327	0	None	-19	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	589	12	3	5	2.4	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)CNC	10.1021/jm800525p
	CHEMBL452710	173327	0	None	-19	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	589	12	3	5	2.4	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)CNC	10.1021/jm800525p
	1334	1489	7	None	1	4	Human	6.3	pEC50	=	6.3	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	16133814	1489	7	None	1	4	Human	6.3	pEC50	=	6.3	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	CHEMBL437050	1489	7	None	1	4	Human	6.3	pEC50	=	6.3	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	164621414	185750	0	None	-7	3	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	531	12	4	4	4.4	CC(C)CCCN1C(=N)N([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C[C@H]1[C@@H](C)O	10.1021/acs.jmedchem.0c02041
	CHEMBL4866532	185750	0	None	-7	3	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	531	12	4	4	4.4	CC(C)CCCN1C(=N)N([C@H](CC2CCCCC2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C[C@H]1[C@@H](C)O	10.1021/acs.jmedchem.0c02041
	CHEMBL503449	214143	0	None	-99	4	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(C)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	CHEMBL444219	213907	0	None	-120	4	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	137636965	156192	0	None	-13	4	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1742	21	20	21	-2.9	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4064433	156192	0	None	-13	4	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1742	21	20	21	-2.9	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	44408173	75372	0	None	-186	4	Human	6.3	pEC50	=	6.3	Functional	Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation	ChEMBL	640	8	2	5	4.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2CCCS2(=O)=O)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	CHEMBL203975	75372	0	None	-186	4	Human	6.3	pEC50	=	6.3	Functional	Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation	ChEMBL	640	8	2	5	4.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2CCCS2(=O)=O)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	137658359	159547	0	None	-33	4	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	791	20	11	7	-1.0	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4102774	159547	0	None	-33	4	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	791	20	11	7	-1.0	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	44413876	79715	0	None	-93	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	710	18	8	7	0.4	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(C)=O	10.1016/j.bmcl.2006.05.087
	CHEMBL211699	79715	0	None	-93	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	710	18	8	7	0.4	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(C)=O	10.1016/j.bmcl.2006.05.087
	44413876	79715	0	None	-93	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	710	18	8	7	0.4	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(C)=O	10.1021/jm060384p
	CHEMBL211699	79715	0	None	-93	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	710	18	8	7	0.4	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(C)=O	10.1021/jm060384p
	25132526	188899	0	None	-69	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	602	10	2	4	4.2	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C(C)(C)C	10.1021/jm800525p
	CHEMBL507876	188899	0	None	-69	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	602	10	2	4	4.2	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C(C)(C)C	10.1021/jm800525p
	118735103	118777	0	None	-1	4	Human	7.3	pEC50	=	7.3	Functional	Activity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterActivity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counter	ChEMBL	698	15	8	9	-0.8	CC(=O)N[C@H]1Cn2nncc2CN([C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	CHEMBL3421680	118777	0	None	-1	4	Human	7.3	pEC50	=	7.3	Functional	Activity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterActivity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counter	ChEMBL	698	15	8	9	-0.8	CC(=O)N[C@H]1Cn2nncc2CN([C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	90643806	111719	0	None	-87	5	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL	728	14	5	8	1.9	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O	10.1021/jm500064t
	CHEMBL3287326	111719	0	None	-87	5	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL	728	14	5	8	1.9	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O	10.1021/jm500064t
	CHEMBL264190	210585	1	None	-35	8	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	44408253	140319	0	None	-54	4	Human	6.3	pEC50	=	6.3	Functional	Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation	ChEMBL	650	10	2	5	6.1	CCOC(=O)N(CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)C(C)C	10.1016/j.bmcl.2005.11.095
	CHEMBL380727	140319	0	None	-54	4	Human	6.3	pEC50	=	6.3	Functional	Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation	ChEMBL	650	10	2	5	6.1	CCOC(=O)N(CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)C(C)C	10.1016/j.bmcl.2005.11.095
	CHEMBL2304248	209462	0	None	-3	4	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)O	10.1021/jm0492756
	CHEMBL183315	209020	0	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	44394734	64527	0	None	-4	3	Human	6.3	pEC50	=	6.3	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	791	19	9	6	2.9	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL181494	64527	0	None	-4	3	Human	6.3	pEC50	=	6.3	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	791	19	9	6	2.9	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	44577520	188800	0	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	904	12	10	11	1.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O	10.1021/jm701181n
	CHEMBL506274	188800	0	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	904	12	10	11	1.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O	10.1021/jm701181n
	CHEMBL5078687	214557	0	None	-25	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	44413913	138648	0	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	672	16	6	7	0.2	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1C(=O)NCCN=C(N)N	10.1021/jm060384p
	CHEMBL377779	138648	0	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	672	16	6	7	0.2	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1C(=O)NCCN=C(N)N	10.1021/jm060384p
	145988152	167020	0	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assayAgonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assay	ChEMBL	720	17	7	6	2.3	CCCC[C@H](NC(=O)[C@@H](Cc1ccc(Br)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	CHEMBL4288909	167020	0	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assayAgonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assay	ChEMBL	720	17	7	6	2.3	CCCC[C@H](NC(=O)[C@@H](Cc1ccc(Br)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	132180599	156869	0	None	1	4	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4072129	156869	0	None	1	4	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.7b00301
	46885759	8244	0	None	-95	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	488	3	1	3	4.9	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1cccc(F)c1	10.1021/jm9017866
	CHEMBL1092548	8244	0	None	-95	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	488	3	1	3	4.9	C[C@H]1CN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1cccc(F)c1	10.1021/jm9017866
	44322994	106970	0	None	-60	3	Human	6.2	pEC50	=	6.2	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	715	20	9	8	-1.0	COCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL315258	106970	0	None	-60	3	Human	6.2	pEC50	=	6.2	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	715	20	9	8	-1.0	COCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	25129108	172672	0	None	-6	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	629	11	3	5	3.5	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1(N)CCCC1	10.1021/jm800525p
	CHEMBL450236	172672	0	None	-6	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	629	11	3	5	3.5	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1(N)CCCC1	10.1021/jm800525p
	44322977	111542	0	None	-8	3	Human	7.2	pEC50	=	7.2	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	714	18	11	8	-1.9	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)C(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL328117	111542	0	None	-8	3	Human	7.2	pEC50	=	7.2	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	714	18	11	8	-1.9	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)C(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	45487414	197258	0	None	-54	4	Mouse	4.2	pEC50	=	4.2	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL	621	16	8	6	0.8	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccc(Cl)cc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL568577	197258	0	None	-54	4	Mouse	4.2	pEC50	=	4.2	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL	621	16	8	6	0.8	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)/C=C/c1ccc(Cl)cc1)C(N)=O	10.1016/j.bmcl.2009.07.025
	11061068	31262	0	None	-138	3	Human	7.2	pEC50	=	7.2	Functional	Evaluated for Functional Activity at MC3R as effective concentration at 50% maximum CMP accumulationEvaluated for Functional Activity at MC3R as effective concentration at 50% maximum CMP accumulation	ChEMBL	603	8	2	7	4.0	Cn1nnnc1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1021/jm025539h
	CHEMBL140154	31262	0	None	-138	3	Human	7.2	pEC50	=	7.2	Functional	Evaluated for Functional Activity at MC3R as effective concentration at 50% maximum CMP accumulationEvaluated for Functional Activity at MC3R as effective concentration at 50% maximum CMP accumulation	ChEMBL	603	8	2	7	4.0	Cn1nnnc1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1021/jm025539h
	CHEMBL2372365	210201	0	None	-1	3	Rat	7.2	pEC50	=	7.2	Functional	Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R)	ChEMBL		None	None	None		C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC(C)(C)[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCN)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O	10.1021/jm030452x
	44408155	140528	0	None	-134	4	Human	6.2	pEC50	=	6.2	Functional	Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation	ChEMBL	656	10	2	5	4.9	CC(C)N(CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)S(C)(=O)=O	10.1016/j.bmcl.2005.11.095
	CHEMBL381125	140528	0	None	-134	4	Human	6.2	pEC50	=	6.2	Functional	Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation	ChEMBL	656	10	2	5	4.9	CC(C)N(CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)S(C)(=O)=O	10.1016/j.bmcl.2005.11.095
	44413932	137521	0	None	-34	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	570	12	5	5	3.1	N=C(N)NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1	10.1021/jm060384p
	CHEMBL375440	137521	0	None	-34	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	570	12	5	5	3.1	N=C(N)NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1	10.1021/jm060384p
	44415918	141524	0	None	-3	3	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	754	16	6	7	0.9	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL384774	141524	0	None	-3	3	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	754	16	6	7	0.9	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	155564058	175310	0	None	-30	4	Mouse	8.2	pEC50	=	8.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	746	14	7	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4574056	175310	0	None	-30	4	Mouse	8.2	pEC50	=	8.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	746	14	7	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	44275650	94025	0	None	-15	4	Human	8.2	pEC50	=	8.2	Functional	Agonistic activity against human melanocortin receptor (hMC3R) for cAMP accumulationAgonistic activity against human melanocortin receptor (hMC3R) for cAMP accumulation	ChEMBL	953	15	12	10	-0.8	CCCCC(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC1=O	10.1016/s0960-894x(03)00114-8
	CHEMBL24892	94025	0	None	-15	4	Human	8.2	pEC50	=	8.2	Functional	Agonistic activity against human melanocortin receptor (hMC3R) for cAMP accumulationAgonistic activity against human melanocortin receptor (hMC3R) for cAMP accumulation	ChEMBL	953	15	12	10	-0.8	CCCCC(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC1=O	10.1016/s0960-894x(03)00114-8
	44322895	163346	0	None	-3	3	Human	8.2	pEC50	=	8.2	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	811	21	10	8	1.3	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)COc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL419307	163346	0	None	-3	3	Human	8.2	pEC50	=	8.2	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	811	21	10	8	1.3	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)COc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL2370964	209944	0	None	-47	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human MC3R transfected in HEK293 cells co-transfected with GScAMP22F assessed as increase in cAMP level by split luciferase cAMP sensor dynamic assayAgonist activity at human MC3R transfected in HEK293 cells co-transfected with GScAMP22F assessed as increase in cAMP level by split luciferase cAMP sensor dynamic assay	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/acs.jmedchem.1c01295
	CHEMBL2370964	209944	0	None	-47	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human MC3R transfected in HEK293 cells co-transfected with GScAMP22F assessed as increase in cAMP level by split luciferase cAMP sensor dynamic assayAgonist activity at human MC3R transfected in HEK293 cells co-transfected with GScAMP22F assessed as increase in cAMP level by split luciferase cAMP sensor dynamic assay	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/acs.jmedchem.1c01295
	CHEMBL5080784	214683	0	None	-9	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL5090285	215230	0	None	-8	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	16132144	209256	36	None	-7	8	Human	8.2	pEC50	=	8.2	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm049579s
	16133793	209256	36	None	-7	8	Human	8.2	pEC50	=	8.2	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm049579s
	44273719	209256	36	None	-7	8	Human	8.2	pEC50	=	8.2	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm049579s
	CHEMBL214332	209256	36	None	-7	8	Human	8.2	pEC50	=	8.2	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm049579s
	16132144	209256	36	None	-7	8	Human	8.2	pEC50	=	8.2	Functional	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm030111j
	16133793	209256	36	None	-7	8	Human	8.2	pEC50	=	8.2	Functional	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm030111j
	44273719	209256	36	None	-7	8	Human	8.2	pEC50	=	8.2	Functional	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm030111j
	CHEMBL214332	209256	36	None	-7	8	Human	8.2	pEC50	=	8.2	Functional	Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm030111j
	1324	301	25	None	-15	9	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00353
	16154396	301	25	None	-15	9	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00353
	16197727	301	25	None	-15	9	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00353
	44285019	301	25	None	-15	9	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00353
	57514683	301	25	None	-15	9	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00353
	91898441	301	25	None	-15	9	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00353
	CHEMBL441738	301	25	None	-15	9	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00353
	DB04931	301	25	None	-15	9	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00353
	CHEMBL405335	212533	0	None	-39	4	Mouse	8.2	pEC50	=	8.2	Functional	Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm010061n
	155539948	172862	0	None	-30	4	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	705	20	11	7	-0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4515666	172862	0	None	-30	4	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	705	20	11	7	-0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	155542149	173068	0	None	-30	3	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	740	17	8	6	1.2	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4520119	173068	0	None	-30	3	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	740	17	8	6	1.2	CC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	155563055	175271	0	None	-12	4	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	686	18	9	7	0.5	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4573041	175271	0	None	-12	4	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	686	18	9	7	0.5	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	162670951	182814	0	None	-4	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1100	18	14	11	0.6	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3ccccc3)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4791306	182814	0	None	-4	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1100	18	14	11	0.6	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3ccccc3)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	46885558	7777	0	None	-151	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	492	4	1	5	4.0	C[C@H]1CN(C(=O)[C@H]2CN(c3ccncn3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1	10.1021/jm9017866
	CHEMBL1089483	7777	0	None	-151	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	492	4	1	5	4.0	C[C@H]1CN(C(=O)[C@H]2CN(c3ccncn3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1	10.1021/jm9017866
	137649368	157382	0	None	-70	4	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	844	15	7	6	2.4	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4078495	157382	0	None	-70	4	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	844	15	7	6	2.4	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	9852256	175343	0	None	-15	4	Mouse	5.2	pEC50	=	5.2	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	632	15	8	7	0.3	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.9b00198
	CHEMBL4574756	175343	0	None	-15	4	Mouse	5.2	pEC50	=	5.2	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	632	15	8	7	0.3	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.9b00198
	162670951	182814	0	None	-4	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1100	18	14	11	0.6	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3ccccc3)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4791306	182814	0	None	-4	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1100	18	14	11	0.6	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3ccccc3)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	137651071	157443	0	None	-158	4	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	794	15	7	6	1.3	CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4079298	157443	0	None	-158	4	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	794	15	7	6	1.3	CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL451423	213945	0	None	-47	4	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	CHEMBL509582	215523	0	None	-16	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2C[C@H](NC(=N)N)CN2C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm801300c
	164625186	185943	0	None	-6	3	Mouse	5.2	pEC50	=	5.2	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	591	11	3	3	6.5	CCC[C@@H]1CN([C@H](Cc2ccccc2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C(=N)N1CC1CCC(C(C)(C)C)CC1	10.1021/acs.jmedchem.0c02041
	CHEMBL4869669	185943	0	None	-6	3	Mouse	5.2	pEC50	=	5.2	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay	ChEMBL	591	11	3	3	6.5	CCC[C@@H]1CN([C@H](Cc2ccccc2)N2CCC[C@H]2CN2C(=N)NC[C@H]2C(C)C)C(=N)N1CC1CCC(C(C)(C)C)CC1	10.1021/acs.jmedchem.0c02041
	137637656	156214	0	None	-69	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1045	20	14	15	-2.2	CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	CHEMBL4064777	156214	0	None	-69	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1045	20	14	15	-2.2	CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	CHEMBL2448525	210476	0	None	-977	4	Mouse	4.2	pEC50	=	4.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)O	10.1021/jm0492756
	CHEMBL411400	212860	0	None	-457	5	Rat	7.2	pEC50	=	7.2	Functional	Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R)	ChEMBL		None	None	None		C[C@@H](O)[C@H](NC(=O)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)CSSC1(C)C)C(N)=O	10.1021/jm030452x
	44408275	75390	0	None	-120	4	Human	6.2	pEC50	=	6.2	Functional	Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation	ChEMBL	620	8	2	5	5.1	C[C@H]1COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.11.095
	CHEMBL204078	75390	0	None	-120	4	Human	6.2	pEC50	=	6.2	Functional	Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation	ChEMBL	620	8	2	5	5.1	C[C@H]1COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.11.095
	44323034	206507	0	None	-46	3	Human	6.2	pEC50	=	6.2	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	729	21	11	8	-0.6	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCCO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL88537	206507	0	None	-46	3	Human	6.2	pEC50	=	6.2	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	729	21	11	8	-0.6	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCCO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	44394735	123289	0	None	-34	3	Human	6.2	pEC50	=	6.2	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	797	19	9	7	2.9	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1cccs1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL361578	123289	0	None	-34	3	Human	6.2	pEC50	=	6.2	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	797	19	9	7	2.9	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1cccs1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	168273822	190546	0	None	-61	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysisAgonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysis	ChEMBL	1106	17	13	12	1.5	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccc(cc2)CSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	CHEMBL5180152	190546	0	None	-61	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysisAgonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysis	ChEMBL	1106	17	13	12	1.5	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccc(cc2)CSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	46885481	7723	0	None	-12	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	491	4	1	4	4.6	C[C@H]1CN(C(=O)[C@H]2CN(c3cccnc3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1	10.1021/jm9017866
	CHEMBL1089104	7723	0	None	-12	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	491	4	1	4	4.6	C[C@H]1CN(C(=O)[C@H]2CN(c3cccnc3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1	10.1021/jm9017866
	162671821	182879	0	None	-4	3	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	725	17	8	7	0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	CHEMBL4792291	182879	0	None	-4	3	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	725	17	8	7	0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acsmedchemlett.0c00561
	CHEMBL415200	213156	0	None	-77	5	Rat	6.2	pEC50	=	6.2	Functional	Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R)	ChEMBL		None	None	None		C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(CCCN)CC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O	10.1021/jm030452x
	CHEMBL184644	209027	0	None	-16	3	Human	5.2	pEC50	=	5.2	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		CS(=O)(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	44394736	123290	0	None	-25	3	Human	6.2	pEC50	=	6.2	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	797	19	9	7	2.9	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1ccsc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL361579	123290	0	None	-25	3	Human	6.2	pEC50	=	6.2	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	797	19	9	7	2.9	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1ccsc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	11846844	140054	0	None	-1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	678	15	5	6	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL380051	140054	0	None	-1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	678	15	5	6	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	44441642	154381	0	None	-77	3	Human	6.2	pEC50	=	6.2	Functional	Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production	ChEMBL	577	9	2	7	3.5	CC(C)CC1(Cc2nnnn2C)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL398816	154381	0	None	-77	3	Human	6.2	pEC50	=	6.2	Functional	Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production	ChEMBL	577	9	2	7	3.5	CC(C)CC1(Cc2nnnn2C)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	137640703	157073	0	None	-1202	4	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1694	20	20	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4074479	157073	0	None	-1202	4	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1694	20	20	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL264190	210585	1	None	-3	8	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assayAgonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	CHEMBL406842	212601	0	None	-66	5	Rat	8.1	pEC50	=	8.1	Functional	Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R)	ChEMBL		None	None	None		C[C@H](O)[C@@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O	10.1021/jm030452x
	CHEMBL5077095	214456	0	None	-57	4	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	162665266	182157	0	None	-1	3	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	668	14	5	6	1.7	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C	10.1021/acsmedchemlett.0c00561
	CHEMBL4782693	182157	0	None	-1	3	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	ChEMBL	668	14	5	6	1.7	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C	10.1021/acsmedchemlett.0c00561
	155549302	173779	0	None	-7	3	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	626	13	5	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	CHEMBL4538209	173779	0	None	-7	3	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	626	13	5	6	0.7	CC(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O)C(C)C	10.1021/acs.jmedchem.9b00053
	1334	1489	7	None	1	4	Human	6.2	pEC50	=	6.2	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	16133814	1489	7	None	1	4	Human	6.2	pEC50	=	6.2	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	CHEMBL437050	1489	7	None	1	4	Human	6.2	pEC50	=	6.2	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	10146211	64299	0	None	-2511	3	Human	5.2	pEC50	=	5.2	Functional	Effective concentration determined against melanocortin-3 receptorEffective concentration determined against melanocortin-3 receptor	ChEMBL	649	10	2	6	3.6	CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.01.060
	CHEMBL181162	64299	0	None	-2511	3	Human	5.2	pEC50	=	5.2	Functional	Effective concentration determined against melanocortin-3 receptorEffective concentration determined against melanocortin-3 receptor	ChEMBL	649	10	2	6	3.6	CS(=O)(=O)N(CC1CC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.01.060
	122184577	122403	0	None	-7	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600838	122403	0	None	-7	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	46885480	7722	0	None	-4	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	491	4	1	4	4.6	C[C@H]1CN(C(=O)[C@H]2CN(c3ccccn3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1	10.1021/jm9017866
	CHEMBL1089103	7722	0	None	-4	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	491	4	1	4	4.6	C[C@H]1CN(C(=O)[C@H]2CN(c3ccccn3)C[C@@H]2c2ccc(F)cc2F)C[C@@H](C)[C@]1(O)c1ccccc1	10.1021/jm9017866
	44322812	112355	0	None	-20	3	Human	7.2	pEC50	=	7.2	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	711	19	10	7	0.0	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)C1CC1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL329586	112355	0	None	-20	3	Human	7.2	pEC50	=	7.2	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	711	19	10	7	0.0	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)C1CC1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL2323800	209503	0	None	-446	4	Mouse	5.2	pEC50	=	5.2	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)[C@]23CCCN2C(=O)[C@@H](CSCC3=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	46232226	201060	0	None	-891	4	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase reporter gene assay	ChEMBL	863	12	9	8	0.7	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(Cc2ccccc2)C(=O)CCCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1016/j.bmc.2009.12.010
	CHEMBL602853	201060	0	None	-891	4	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase reporter gene assay	ChEMBL	863	12	9	8	0.7	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(Cc2ccccc2)C(=O)CCCCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1016/j.bmc.2009.12.010
	CHEMBL5075506	214356	0	None	-512	4	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	155549865	173832	0	None	-18	4	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	658	17	7	7	0.5	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4539175	173832	0	None	-18	4	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	658	17	7	7	0.5	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O	10.1021/acs.jmedchem.9b00053
	137647009	157830	0	None	-30	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1122	22	14	16	-1.6	CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	CHEMBL4083755	157830	0	None	-30	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1122	22	14	16	-1.6	CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	145964837	164323	0	None	-1	4	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	875	11	12	9	-0.5	CC1(C)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4212629	164323	0	None	-1	4	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	875	11	12	9	-0.5	CC1(C)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL264190	210585	1	None	-35	8	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	45487413	197228	0	None	-6	4	Mouse	5.1	pEC50	=	5.1	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL	616	15	10	7	-0.1	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)c1cc2cc(O)ccc2[nH]1)C(N)=O	10.1016/j.bmcl.2009.07.025
	CHEMBL568409	197228	0	None	-6	4	Mouse	5.1	pEC50	=	5.1	Functional	Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R	ChEMBL	616	15	10	7	-0.1	N=C(N)NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)c1cc2cc(O)ccc2[nH]1)C(N)=O	10.1016/j.bmcl.2009.07.025
	137646617	157520	0	None	-5	4	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1728	21	21	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4080223	157520	0	None	-5	4	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1728	21	21	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	46885524	7772	0	None	-354	3	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	458	5	1	5	3.6	CCC[C@]1(O)[C@@H](C)CN(C(=O)[C@H]2CN(c3cccnn3)C[C@@H]2c2ccc(F)cc2F)C[C@H]1C	10.1021/jm9017866
	CHEMBL1089462	7772	0	None	-354	3	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	458	5	1	5	3.6	CCC[C@]1(O)[C@@H](C)CN(C(=O)[C@H]2CN(c3cccnn3)C[C@@H]2c2ccc(F)cc2F)C[C@H]1C	10.1021/jm9017866
	CHEMBL1204054	7772	0	None	-354	3	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay	ChEMBL	458	5	1	5	3.6	CCC[C@]1(O)[C@@H](C)CN(C(=O)[C@H]2CN(c3cccnn3)C[C@@H]2c2ccc(F)cc2F)C[C@H]1C	10.1021/jm9017866
	1324	301	25	None	-6	9	Mouse	7.1	pEC50	=	7.1	Functional	Compound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cellsCompound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cells	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00318-4
	16154396	301	25	None	-6	9	Mouse	7.1	pEC50	=	7.1	Functional	Compound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cellsCompound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cells	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00318-4
	16197727	301	25	None	-6	9	Mouse	7.1	pEC50	=	7.1	Functional	Compound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cellsCompound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cells	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00318-4
	44285019	301	25	None	-6	9	Mouse	7.1	pEC50	=	7.1	Functional	Compound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cellsCompound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cells	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00318-4
	57514683	301	25	None	-6	9	Mouse	7.1	pEC50	=	7.1	Functional	Compound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cellsCompound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cells	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00318-4
	91898441	301	25	None	-6	9	Mouse	7.1	pEC50	=	7.1	Functional	Compound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cellsCompound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cells	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00318-4
	CHEMBL441738	301	25	None	-6	9	Mouse	7.1	pEC50	=	7.1	Functional	Compound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cellsCompound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cells	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00318-4
	DB04931	301	25	None	-6	9	Mouse	7.1	pEC50	=	7.1	Functional	Compound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cellsCompound was evaluated for its agonist activity on mouse melanocortin receptor 3 (mMC3R) stably expressed in HEK cells	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00318-4
	CHEMBL406891	212603	0	None	-34	5	Rat	7.1	pEC50	=	7.1	Functional	Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R)	ChEMBL		None	None	None		C[C@@H](O)[C@H](NC(=O)[C@H]1CCSSC[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O	10.1021/jm030452x
	CHEMBL3349030	211382	0	None	1	3	Human	6.1	pEC50	=	6.1	Functional	Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorEffective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	CHEMBL3600922	211802	0	None	-4	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	44394730	132462	0	None	-53	3	Human	6.1	pEC50	=	6.1	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	772	21	10	7	0.3	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CNC=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL369770	132462	0	None	-53	3	Human	6.1	pEC50	=	6.1	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	772	21	10	7	0.3	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CNC=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	137647538	157938	0	None	-1445	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1680	20	21	21	-3.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4084765	157938	0	None	-1445	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1680	20	21	21	-3.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	145975465	163925	0	None	-6	4	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	825	11	12	9	-1.6	CC1(C)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4207725	163925	0	None	-6	4	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	825	11	12	9	-1.6	CC1(C)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	145964017	164017	0	None	-1	4	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	915	11	12	9	0.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4208874	164017	0	None	-1	4	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsAgonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	ChEMBL	915	11	12	9	0.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	53318436	58773	0	None	-46	4	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	814	17	10	9	-0.4	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H]1CSCC(=O)N([C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C[C@H](CCCNC(=N)N)NC1=O	10.1021/jm101425m
	CHEMBL1688108	58773	0	None	-46	4	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay	ChEMBL	814	17	10	9	-0.4	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H]1CSCC(=O)N([C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C[C@H](CCCNC(=N)N)NC1=O	10.1021/jm101425m
	46919520	15106	0	None	-549	6	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human melanocortin 3 receptor expressed in CHO cells assessed as cAMP releaseAgonist activity at human melanocortin 3 receptor expressed in CHO cells assessed as cAMP release	ChEMBL	597	4	0	5	6.3	Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N	10.1016/j.bmcl.2010.06.068
	CHEMBL1209788	15106	0	None	-549	6	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human melanocortin 3 receptor expressed in CHO cells assessed as cAMP releaseAgonist activity at human melanocortin 3 receptor expressed in CHO cells assessed as cAMP release	ChEMBL	597	4	0	5	6.3	Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N	10.1016/j.bmcl.2010.06.068
	162643435	181643	0	None	4	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3cccc4ccccc34)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4776340	181643	0	None	4	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3cccc4ccccc34)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162643435	181643	0	None	4	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3cccc4ccccc34)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4776340	181643	0	None	4	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3cccc4ccccc34)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	122184912	122532	0	None	-3	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3601430	122532	0	None	-3	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	15602927	157858	0	None	-194	5	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cellsAgonist activity at mouse MC3R expressed in HEK293 cells	ChEMBL	835	12	10	8	-0.4	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701093y
	CHEMBL408398	157858	0	None	-194	5	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cellsAgonist activity at mouse MC3R expressed in HEK293 cells	ChEMBL	835	12	10	8	-0.4	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCC(=O)NCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701093y
	CHEMBL455826	213986	0	None	-15	4	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cc2ccccc2)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	CHEMBL2323792	209495	0	None	1	4	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	44457067	97714	0	None	-1548	5	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cellsAgonist activity at mouse MC3R expressed in HEK293 cells	ChEMBL	877	12	10	8	0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCC(=O)NCCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701093y
	CHEMBL271586	97714	0	None	-1548	5	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cellsAgonist activity at mouse MC3R expressed in HEK293 cells	ChEMBL	877	12	10	8	0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCC(=O)NCCCN(CC(N)=O)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701093y
	44335147	4560	0	None	-12	4	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)	ChEMBL	711	16	9	7	-0.3	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NC1(C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)CCc2ccccc2C1	10.1021/jm010524p
	CHEMBL102688	4560	0	None	-12	4	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)	ChEMBL	711	16	9	7	-0.3	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NC1(C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)CCc2ccccc2C1	10.1021/jm010524p
	49862377	15009	0	None	-13	4	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationAgonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation	ChEMBL	654	9	0	6	6.2	CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(=O)c1cnn(C(C)C)c1	10.1016/j.bmcl.2010.06.038
	CHEMBL1209320	15009	0	None	-13	4	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationAgonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation	ChEMBL	654	9	0	6	6.2	CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(=O)c1cnn(C(C)C)c1	10.1016/j.bmcl.2010.06.038
	155543031	173157	0	None	-13	4	Mouse	8.1	pEC50	=	8.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	803	17	10	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4522298	173157	0	None	-13	4	Mouse	8.1	pEC50	=	8.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	803	17	10	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	155560756	175061	0	None	-15	4	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	756	14	6	7	-0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL4568647	175061	0	None	-15	4	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assayAgonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay	ChEMBL	756	14	6	7	-0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00053
	CHEMBL3600921	211801	0	None	-1	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL2323797	209500	0	None	-426	4	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@H]1CN2C(=O)CSC[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccc(O)cc3)CSSC[C@@H](C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2Cc2c[nH]c3ccccc23)C(=O)N1	10.1021/jm301253y
	137648144	157734	0	None	-38	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1127	22	14	17	-1.5	CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2csc3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	CHEMBL4082585	157734	0	None	-38	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayAgonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assay	ChEMBL	1127	22	14	17	-1.5	CSCC[C@H](NC(=O)[C@@H]1Cc2cn(nn2)C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2csc3ccccc23)C(=O)N1)C(=O)O	10.1021/acs.jmedchem.7b00353
	11845438	137598	0	None	-8	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	661	12	6	6	2.4	N=C(N)NCCNC(=O)[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1	10.1021/jm060384p
	CHEMBL375775	137598	0	None	-8	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	661	12	6	6	2.4	N=C(N)NCCNC(=O)[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1	10.1021/jm060384p
	44394627	124055	0	None	-7	3	Human	6.1	pEC50	=	6.1	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	757	20	8	6	2.1	CCCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL363272	124055	0	None	-7	3	Human	6.1	pEC50	=	6.1	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	757	20	8	6	2.1	CCCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	44416135	80155	0	None	-38	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	561	10	5	5	1.1	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCNC(=N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL213566	80155	0	None	-38	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MC3RAgonist activity at human MC3R	ChEMBL	561	10	5	5	1.1	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCNC(=N)N)C1=O	10.1016/j.bmcl.2006.05.087
	25133208	171970	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	615	11	3	5	3.1	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1(N)CCC1	10.1021/jm800525p
	CHEMBL447117	171970	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	615	11	3	5	3.1	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1(N)CCC1	10.1021/jm800525p
	CHEMBL491870	214054	0	None	-213	5	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	44441646	154064	0	None	-10	3	Human	6.1	pEC50	=	6.1	Functional	Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production	ChEMBL	611	9	2	7	3.7	Cn1nnnc1CC1(Cc2ccccc2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL398487	154064	0	None	-10	3	Human	6.1	pEC50	=	6.1	Functional	Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production	ChEMBL	611	9	2	7	3.7	Cn1nnnc1CC1(Cc2ccccc2)CCN(C(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2006.11.084
	CHEMBL88185	215873	0	None	-38	3	Human	6.1	pEC50	=	6.1	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL		None	None	None		CS(=O)(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	25133207	172919	0	None	-18	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	601	11	3	5	2.7	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1(N)CC1	10.1021/jm800525p
	CHEMBL451694	172919	0	None	-18	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	601	11	3	5	2.7	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1(N)CC1	10.1021/jm800525p
	44413930	138623	0	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	678	15	5	6	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL377620	138623	0	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	678	15	5	6	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	122179551	121460	0	None	-22	4	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayAgonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	ChEMBL	699	19	10	7	0.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.5b00053
	CHEMBL3582445	121460	0	None	-22	4	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayAgonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	ChEMBL	699	19	10	7	0.0	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.5b00053
	44394787	165964	0	None	-4	3	Human	6.1	pEC50	=	6.1	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	821	21	9	7	2.6	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)COc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL425348	165964	0	None	-4	3	Human	6.1	pEC50	=	6.1	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	821	21	9	7	2.6	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)COc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL181161	208957	0	None	-10	3	Human	7.1	pEC50	=	7.1	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		CNC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	44394585	66736	0	None	-63	3	Human	6.1	pEC50	=	6.1	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	755	20	9	6	2.1	C=CCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL185868	66736	0	None	-63	3	Human	6.1	pEC50	=	6.1	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	755	20	9	6	2.1	C=CCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	137636677	156076	0	None	-295	4	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1680	20	21	21	-3.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4063111	156076	0	None	-295	4	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	ChEMBL	1680	20	21	21	-3.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	11845813	139779	0	None	-5	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	473	10	3	4	3.0	NC(N)=NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@H](N)Cc1ccccc1	10.1021/jm060384p
	CHEMBL379879	139779	0	None	-5	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells	ChEMBL	473	10	3	4	3.0	NC(N)=NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@H](N)Cc1ccccc1	10.1021/jm060384p
	CHEMBL410217	212785	0	None	-38	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptor	ChEMBL		None	None	None		CC(=O)N[C@@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC1=O	10.1021/jm960845e
	44408252	140644	0	None	-77	4	Human	6.1	pEC50	=	6.1	Functional	Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation	ChEMBL	605	8	3	4	4.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2CCNC2=O)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	CHEMBL381503	140644	0	None	-77	4	Human	6.1	pEC50	=	6.1	Functional	Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation	ChEMBL	605	8	3	4	4.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2CCNC2=O)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	49862378	15010	0	None	-83	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationAgonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation	ChEMBL	534	8	0	4	4.6	CC(=O)N(CC(CC(C)C)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(C)C	10.1016/j.bmcl.2010.06.038
	CHEMBL1209321	15010	0	None	-83	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationAgonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation	ChEMBL	534	8	0	4	4.6	CC(=O)N(CC(CC(C)C)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(C)C	10.1016/j.bmcl.2010.06.038
	44394584	96541	0	None	-5	3	Human	6.1	pEC50	=	6.1	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	797	19	9	6	2.5	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CC(F)(F)F)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL263047	96541	0	None	-5	3	Human	6.1	pEC50	=	6.1	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	797	19	9	6	2.5	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CC(F)(F)F)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	137636060	156207	0	None	2	2	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	850	15	7	7	2.5	CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4064728	156207	0	None	2	2	Mouse	5.1	pEC50	=	5.1	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	850	15	7	7	2.5	CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	10078903	67990	0	None	-28	4	Mouse	8.0	pEC50	=	8.0	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL	769	24	9	7	1.8	CCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	CHEMBL191303	67990	0	None	-28	4	Mouse	8.0	pEC50	=	8.0	Functional	In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor	ChEMBL	769	24	9	7	1.8	CCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0490843
	44323029	207158	0	None	-1	3	Human	8.0	pEC50	=	8.0	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	795	20	10	7	1.5	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL92481	207158	0	None	-1	3	Human	8.0	pEC50	=	8.0	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	795	20	10	7	1.5	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	168285801	191457	0	None	1	4	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysisAgonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysis	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(N)=O)CSCc2cccc(c2)CSC1(C)C	10.1021/acs.jmedchem.1c01848
	CHEMBL5193501	191457	0	None	1	4	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysisAgonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysis	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(N)=O)CSCc2cccc(c2)CSC1(C)C	10.1021/acs.jmedchem.1c01848
	CHEMBL3600841	211795	0	None	1	4	Human	8.0	pEC50	=	8	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	49862375	15007	0	None	-16	4	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationAgonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation	ChEMBL	624	8	0	6	5.2	CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(=O)c1cccnn1	10.1016/j.bmcl.2010.06.038
	CHEMBL1209318	15007	0	None	-16	4	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationAgonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation	ChEMBL	624	8	0	6	5.2	CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(=O)c1cccnn1	10.1016/j.bmcl.2010.06.038
	163196518	192105	2	None	-52	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysisAgonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysis	ChEMBL	1106	17	13	12	1.5	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2cccc(c2)CSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	CHEMBL5203580	192105	2	None	-52	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysisAgonist activity at human MC3R expressed in HEK293 cells assessed as maximal intracellular cAMP accumulation by fluorescence based analysis	ChEMBL	1106	17	13	12	1.5	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2cccc(c2)CSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	CHEMBL187125	209032	0	None	-30	3	Human	6.0	pEC50	=	6.0	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)Nc1ccco1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	44448631	95041	0	None	-416	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human MC3R expressed in CHO cells assessed as cAMP releaseAgonist activity at human MC3R expressed in CHO cells assessed as cAMP release	ChEMBL	619	6	1	3	7.0	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(Br)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL255286	95041	0	None	-416	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human MC3R expressed in CHO cells assessed as cAMP releaseAgonist activity at human MC3R expressed in CHO cells assessed as cAMP release	ChEMBL	619	6	1	3	7.0	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(Br)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL359765	211784	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)Nc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL343094	211674	0	None	-57	4	Mouse	5.0	pEC50	=	5.0	Functional	Agonistic activity evaluated at melanocortin 3 receptor (MC3R) of mouse HEK293 cellsAgonistic activity evaluated at melanocortin 3 receptor (MC3R) of mouse HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2003.08.078
	44322987	96703	0	None	-20	3	Human	7.0	pEC50	=	7.0	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	713	20	9	7	0.2	CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL264306	96703	0	None	-20	3	Human	7.0	pEC50	=	7.0	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	713	20	9	7	0.2	CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	137653704	158609	0	None	-6	4	Mouse	6.0	pEC50	=	6.0	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	838	18	8	7	2.2	CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4092424	158609	0	None	-6	4	Mouse	6.0	pEC50	=	6.0	Functional	Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	838	18	8	7	2.2	CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	90643808	111720	0	None	-93	5	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL	747	16	7	8	1.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O	10.1021/jm500064t
	CHEMBL3287328	111720	0	None	-93	5	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs	ChEMBL	747	16	7	8	1.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(N)=O	10.1021/jm500064t
	24774356	94796	0	None	8	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL	861	9	10	8	0.9	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)c2ccccc2C(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL253574	94796	0	None	8	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation	ChEMBL	861	9	10	8	0.9	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)c2ccccc2C(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL5091245	215277	0	None	-26	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assayAgonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL414778	213133	0	None	-154	4	Human	6.0	pEC50	=	6.0	Functional	Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON	10.1021/jm049579s
	CHEMBL50056	214096	2	None	-138	7	Mouse	6.0	pEC50	=	6.0	Functional	Agonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayAgonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acsmedchemlett.5b00053
	44394586	126753	0	None	-13	3	Human	6.0	pEC50	=	6.0	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	759	20	8	7	1.0	COCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL365385	126753	0	None	-13	3	Human	6.0	pEC50	=	6.0	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	759	20	8	7	1.0	COCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	44448629	167439	0	None	-346	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human MC3R expressed in CHO cells assessed as cAMP releaseAgonist activity at human MC3R expressed in CHO cells assessed as cAMP release	ChEMBL	619	6	1	3	7.0	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Br)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL429854	167439	0	None	-346	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human MC3R expressed in CHO cells assessed as cAMP releaseAgonist activity at human MC3R expressed in CHO cells assessed as cAMP release	ChEMBL	619	6	1	3	7.0	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Br)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL2112008	209203	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorEffective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	44323033	107125	0	None	-14	3	Human	7.0	pEC50	=	7.0	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	747	19	10	7	0.9	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL316259	107125	0	None	-14	3	Human	7.0	pEC50	=	7.0	Functional	In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)	ChEMBL	747	19	10	7	0.9	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	25132867	172474	0	None	-38	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	623	11	2	5	3.9	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)c1ccccn1	10.1021/jm800525p
	CHEMBL448337	172474	0	None	-38	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay	ChEMBL	623	11	2	5	3.9	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)c1ccccn1	10.1021/jm800525p
	44408276	75478	0	None	-134	4	Human	6.0	pEC50	=	6	Functional	Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation	ChEMBL	632	8	2	5	5.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2C(=O)OCC23CC3)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	CHEMBL204308	75478	0	None	-134	4	Human	6.0	pEC50	=	6	Functional	Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation	ChEMBL	632	8	2	5	5.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2C(=O)OCC23CC3)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	6918813	131345	3	None	-144	4	Human	6.0	pEC50	=	6	Functional	Effective concentration towards human melanocortin-3 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-3 receptor mediated cAMP accumulation in CHO cells	ChEMBL	557	7	3	5	2.9	CN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	CHEMBL368876	131345	3	None	-144	4	Human	6.0	pEC50	=	6	Functional	Effective concentration towards human melanocortin-3 receptor mediated cAMP accumulation in CHO cellsEffective concentration towards human melanocortin-3 receptor mediated cAMP accumulation in CHO cells	ChEMBL	557	7	3	5	2.9	CN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	44335147	4560	0	None	-12	4	Mouse	5.0	pEC50	=	5	Functional	Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)	ChEMBL	711	16	9	7	-0.3	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NC1(C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)CCc2ccccc2C1	10.1021/jm010524p
	CHEMBL102688	4560	0	None	-12	4	Mouse	5.0	pEC50	=	5	Functional	Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)	ChEMBL	711	16	9	7	-0.3	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NC1(C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)CCc2ccccc2C1	10.1021/jm010524p
	44394692	66184	0	None	-33	3	Human	6.0	pEC50	=	6	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	792	19	9	7	2.2	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1ccncc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	CHEMBL184466	66184	0	None	-33	3	Human	6.0	pEC50	=	6	Functional	Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor	ChEMBL	792	19	9	7	2.2	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1ccncc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.bmcl.2004.07.046
	11753695	8361	7	None	-501	8	Rat	6.0	pEC50	=	6	Functional	Agonist activity at rat MC3R expressed in CHO cells assessed as stimulation of intracellular cAMP accumulationAgonist activity at rat MC3R expressed in CHO cells assessed as stimulation of intracellular cAMP accumulation	ChEMBL	599	4	1	3	6.7	CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21	10.1016/j.bmcl.2010.02.058
	CHEMBL1093304	8361	7	None	-501	8	Rat	6.0	pEC50	=	6	Functional	Agonist activity at rat MC3R expressed in CHO cells assessed as stimulation of intracellular cAMP accumulationAgonist activity at rat MC3R expressed in CHO cells assessed as stimulation of intracellular cAMP accumulation	ChEMBL	599	4	1	3	6.7	CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21	10.1016/j.bmcl.2010.02.058
	CHEMBL2370968	209948	0	None	-63	4	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human MC3R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level in presence of 30 nM alpha-MSH by split luciferase cAMP sensor dynamic assayAntagonist activity at human MC3R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level in presence of 30 nM alpha-MSH by split luciferase cAMP sensor dynamic assay	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/acs.jmedchem.1c01295
	CHEMBL2370968	209948	0	None	-63	4	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human MC3R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level in presence of 30 nM alpha-MSH by split luciferase cAMP sensor dynamic assayAntagonist activity at human MC3R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level in presence of 30 nM alpha-MSH by split luciferase cAMP sensor dynamic assay	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/acs.jmedchem.1c01295
	CHEMBL2370964	209944	0	None	-47	4	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human MC3R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level in presence of 30 nM alpha-MSH by split luciferase cAMP sensor dynamic assayAntagonist activity at human MC3R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level in presence of 30 nM alpha-MSH by split luciferase cAMP sensor dynamic assay	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/acs.jmedchem.1c01295
	CHEMBL2370964	209944	0	None	-47	4	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human MC3R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level in presence of 30 nM alpha-MSH by split luciferase cAMP sensor dynamic assayAntagonist activity at human MC3R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level in presence of 30 nM alpha-MSH by split luciferase cAMP sensor dynamic assay	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/acs.jmedchem.1c01295
	162673640	182958	0	None	-20	2	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1075	17	15	12	-1.3	CC(=O)N[C@@H](CCCN)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4793346	182958	0	None	-20	2	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1075	17	15	12	-1.3	CC(=O)N[C@@H](CCCN)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162673640	182958	0	None	-20	2	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1075	17	15	12	-1.3	CC(=O)N[C@@H](CCCN)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4793346	182958	0	None	-20	2	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1075	17	15	12	-1.3	CC(=O)N[C@@H](CCCN)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162677173	183504	0	None	-2	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1088	18	14	11	0.5	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4799891	183504	0	None	-2	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1088	18	14	11	0.5	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162677173	183504	0	None	-2	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1088	18	14	11	0.5	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4799891	183504	0	None	-2	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1088	18	14	11	0.5	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162664942	182169	0	None	-2	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1158	16	14	11	1.3	CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4782808	182169	0	None	-2	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1158	16	14	11	1.3	CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162644475	181781	0	None	-2	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1110	16	12	10	2.0	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2C[C@H](c3ccccc3)CN2C1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4778074	181781	0	None	-2	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1110	16	12	10	2.0	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2C[C@H](c3ccccc3)CN2C1=O	10.1021/acs.jmedchem.0c01620
	162644475	181781	0	None	-2	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1110	16	12	10	2.0	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2C[C@H](c3ccccc3)CN2C1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4778074	181781	0	None	-2	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1110	16	12	10	2.0	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2C[C@H](c3ccccc3)CN2C1=O	10.1021/acs.jmedchem.0c01620
	101043845	190368	1	None	-4	2	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human MC3R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level in presence of 30 nM alpha-MSH by split luciferase cAMP sensor dynamic assayAntagonist activity at human MC3R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level in presence of 30 nM alpha-MSH by split luciferase cAMP sensor dynamic assay	ChEMBL	1220	17	14	11	1.9	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.1c01295
	CHEMBL5177536	190368	1	None	-4	2	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human MC3R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level in presence of 30 nM alpha-MSH by split luciferase cAMP sensor dynamic assayAntagonist activity at human MC3R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level in presence of 30 nM alpha-MSH by split luciferase cAMP sensor dynamic assay	ChEMBL	1220	17	14	11	1.9	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.1c01295
	101043845	190368	1	None	-4	2	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human MC3R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level in presence of 30 nM alpha-MSH by split luciferase cAMP sensor dynamic assayAntagonist activity at human MC3R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level in presence of 30 nM alpha-MSH by split luciferase cAMP sensor dynamic assay	ChEMBL	1220	17	14	11	1.9	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.1c01295
	CHEMBL5177536	190368	1	None	-4	2	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human MC3R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level in presence of 30 nM alpha-MSH by split luciferase cAMP sensor dynamic assayAntagonist activity at human MC3R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level in presence of 30 nM alpha-MSH by split luciferase cAMP sensor dynamic assay	ChEMBL	1220	17	14	11	1.9	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.1c01295
	162668987	182566	0	None	-6	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1092	17	14	11	0.3	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3c(F)cccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4788071	182566	0	None	-6	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1092	17	14	11	0.3	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3c(F)cccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162668987	182566	0	None	-6	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1092	17	14	11	0.3	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3c(F)cccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4788071	182566	0	None	-6	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1092	17	14	11	0.3	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3c(F)cccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162674869	183290	0	None	-2	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1114	16	14	11	0.9	CC(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4797266	183290	0	None	-2	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1114	16	14	11	0.9	CC(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162674869	183290	0	None	-2	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1114	16	14	11	0.9	CC(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4797266	183290	0	None	-2	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1114	16	14	11	0.9	CC(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162665567	182325	0	None	-4	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1110	16	12	10	2.0	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2C[C@@H](c3ccccc3)CN2C1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4784635	182325	0	None	-4	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1110	16	12	10	2.0	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2C[C@@H](c3ccccc3)CN2C1=O	10.1021/acs.jmedchem.0c01620
	162665567	182325	0	None	-4	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1110	16	12	10	2.0	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2C[C@@H](c3ccccc3)CN2C1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4784635	182325	0	None	-4	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1110	16	12	10	2.0	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2C[C@@H](c3ccccc3)CN2C1=O	10.1021/acs.jmedchem.0c01620
	162672763	183100	0	None	-6	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1092	17	14	11	0.3	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccc(F)cc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4794990	183100	0	None	-6	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1092	17	14	11	0.3	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccc(F)cc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162672763	183100	0	None	-6	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1092	17	14	11	0.3	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccc(F)cc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4794990	183100	0	None	-6	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1092	17	14	11	0.3	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccc(F)cc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162667953	182513	0	None	-2	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1088	15	12	10	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CC3CCCCC3N2C1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4787322	182513	0	None	-2	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1088	15	12	10	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CC3CCCCC3N2C1=O	10.1021/acs.jmedchem.0c01620
	162667953	182513	0	None	-2	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1088	15	12	10	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CC3CCCCC3N2C1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4787322	182513	0	None	-2	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1088	15	12	10	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CC3CCCCC3N2C1=O	10.1021/acs.jmedchem.0c01620
	162675203	183237	0	None	-10	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1122	16	14	11	1.4	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(NC(=N)N)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4796506	183237	0	None	-10	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1122	16	14	11	1.4	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(NC(=N)N)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162675203	183237	0	None	-10	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1122	16	14	11	1.4	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(NC(=N)N)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4796506	183237	0	None	-10	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1122	16	14	11	1.4	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(NC(=N)N)cc2)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	10855168	181882	0	None	-2	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1050	15	13	11	-0.4	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4779301	181882	0	None	-2	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1050	15	13	11	-0.4	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/acs.jmedchem.0c01620
	10855168	181882	0	None	-2	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1050	15	13	11	-0.4	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4779301	181882	0	None	-2	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1050	15	13	11	-0.4	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/acs.jmedchem.0c01620
	162673931	183034	0	None	-2	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1098	17	13	13	0.4	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cc2cn(nn2)CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4794168	183034	0	None	-2	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1098	17	13	13	0.4	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cc2cn(nn2)CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162673931	183034	0	None	-2	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1098	17	13	13	0.4	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cc2cn(nn2)CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4794168	183034	0	None	-2	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1098	17	13	13	0.4	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cc2cn(nn2)CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	101176453	182938	0	None	-660	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1034	15	12	10	0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4792986	182938	0	None	-660	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1034	15	12	10	0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/acs.jmedchem.0c01620
	101176453	182938	0	None	-660	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1034	15	12	10	0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4792986	182938	0	None	-660	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1034	15	12	10	0.7	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/acs.jmedchem.0c01620
	162643518	181687	0	None	-102	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1075	17	15	12	-1.3	CC(=O)N[C@H](CCCN)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4776915	181687	0	None	-102	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1075	17	15	12	-1.3	CC(=O)N[C@H](CCCN)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162643518	181687	0	None	-102	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1075	17	15	12	-1.3	CC(=O)N[C@H](CCCN)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4776915	181687	0	None	-102	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1075	17	15	12	-1.3	CC(=O)N[C@H](CCCN)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162675582	183436	0	None	-5	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1108	16	14	11	0.2	CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4799036	183436	0	None	-5	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1108	16	14	11	0.2	CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162675582	183436	0	None	-5	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1108	16	14	11	0.2	CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4799036	183436	0	None	-5	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1108	16	14	11	0.2	CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162672837	182997	0	None	-17	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1098	17	13	13	0.4	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cc2cnnn2CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4793821	182997	0	None	-17	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1098	17	13	13	0.4	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cc2cnnn2CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162672837	182997	0	None	-17	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1098	17	13	13	0.4	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cc2cnnn2CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4793821	182997	0	None	-17	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1098	17	13	13	0.4	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cc2cnnn2CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162676295	183429	0	None	-2	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1092	17	14	11	0.3	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3cc(F)ccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4798971	183429	0	None	-2	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1092	17	14	11	0.3	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3cc(F)ccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162677133	183533	0	None	-9	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1108	17	14	11	0.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccc(Cl)cc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4800268	183533	0	None	-9	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1108	17	14	11	0.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccc(Cl)cc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162677133	183533	0	None	-9	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1108	17	14	11	0.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccc(Cl)cc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4800268	183533	0	None	-9	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1108	17	14	11	0.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccc(Cl)cc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162676295	183429	0	None	-2	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1092	17	14	11	0.3	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3cc(F)ccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4798971	183429	0	None	-2	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1092	17	14	11	0.3	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3cc(F)ccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162643092	181700	0	None	-1	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1108	17	14	11	0.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3cc(Cl)ccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4777048	181700	0	None	-1	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1108	17	14	11	0.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3cc(Cl)ccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162643092	181700	0	None	-1	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1108	17	14	11	0.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3cc(Cl)ccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4777048	181700	0	None	-1	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1108	17	14	11	0.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3cc(Cl)ccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162673650	183029	0	None	-2	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1108	17	14	11	0.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3c(Cl)cccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4794121	183029	0	None	-2	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1108	17	14	11	0.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3c(Cl)cccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162673650	183029	0	None	-2	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1108	17	14	11	0.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3c(Cl)cccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4794121	183029	0	None	-2	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1108	17	14	11	0.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3c(Cl)cccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	1325	3573	14	None	-125	5	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	6440621	3573	14	None	-125	5	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	9898183	3573	14	None	-125	5	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	CHEMBL3422426	3573	14	None	-125	5	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	1325	3573	14	None	-125	5	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	6440621	3573	14	None	-125	5	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	9898183	3573	14	None	-125	5	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	CHEMBL3422426	3573	14	None	-125	5	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	162664942	182169	0	None	-2	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1158	16	14	11	1.3	CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4782808	182169	0	None	-2	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assayAntagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay	ChEMBL	1158	16	14	11	1.3	CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL253364	210486	0	None	-	0	Human	10.6	pKd	=	10.6	Functional	Antagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT2 induced intracellular cAMP accumulationAntagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT2 induced intracellular cAMP accumulation	ChEMBL		None	None	None		N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](N)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL2323796	209499	0	None	-	3	Mouse	9.9	pKd	=	9.9	Functional	Antagonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAntagonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	44445083	154281	0	None	2	3	Human	9.8	pKd	=	9.8	Functional	Antagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT2 induced intracellular cAMP accumulationAntagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT2 induced intracellular cAMP accumulation	ChEMBL	953	9	10	9	2.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)c2ccccc2C(=O)CCCNCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL398665	154281	0	None	2	3	Human	9.8	pKd	=	9.8	Functional	Antagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT2 induced intracellular cAMP accumulationAntagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT2 induced intracellular cAMP accumulation	ChEMBL	953	9	10	9	2.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)c2ccccc2C(=O)CCCNCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	122184576	122402	0	None	1	4	Human	9.1	pKd	=	9.1	Functional	Antagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT-II-induced intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAntagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT-II-induced intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600837	122402	0	None	1	4	Human	9.1	pKd	=	9.1	Functional	Antagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT-II-induced intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAntagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT-II-induced intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	164619641	185702	0	None	-	0	Mouse	9.0	pKd	=	9	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4865888	185702	0	None	-	0	Mouse	9.0	pKd	=	9	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL266288	96934	0	None	-	1	Mouse	8.9	pKd	=	8.9	Functional	Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor	ChEMBL	5507	70	67	87	-15.6	CSCC[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]2CSSSSC[C@@H]3NC(=O)[C@@H]4CCCN4C(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]4CSSSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC(=O)[C@H](CSSSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)O)[C@@H](C)O)NC(=O)[C@@H]5CCCN5C(=O)[C@H](CC(N)=O)NC1=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CSSSSC[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N4)NC3=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CSSSSC[C@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCCN=C(N)N)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N2	10.1021/jm0303608
	164613340	184696	0	None	-	0	Mouse	8.8	pKd	=	8.8	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	765	20	11	7	0.7	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4850510	184696	0	None	-	0	Mouse	8.8	pKd	=	8.8	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	765	20	11	7	0.7	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	127035019	136411	0	None	-	1	Mouse	8.8	pKd	=	8.8	Functional	Partial agonist activity at mouse MC3 receptor expressed in HEK293 cells assessed as NDP-MSH induced response by cAMP alpha screen based schild analysisPartial agonist activity at mouse MC3 receptor expressed in HEK293 cells assessed as NDP-MSH induced response by cAMP alpha screen based schild analysis	ChEMBL	1074	17	14	11	0.1	CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1016/j.bmcl.2015.10.095
	CHEMBL3735607	136411	0	None	-	1	Mouse	8.8	pKd	=	8.8	Functional	Partial agonist activity at mouse MC3 receptor expressed in HEK293 cells assessed as NDP-MSH induced response by cAMP alpha screen based schild analysisPartial agonist activity at mouse MC3 receptor expressed in HEK293 cells assessed as NDP-MSH induced response by cAMP alpha screen based schild analysis	ChEMBL	1074	17	14	11	0.1	CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1016/j.bmcl.2015.10.095
	CHEMBL2096742	209183	0	None	-3	6	Human	8.7	pKd	=	8.7	Functional	Antagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT2 induced intracellular cAMP accumulationAntagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT2 induced intracellular cAMP accumulation	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm070461w
	164612217	184821	0	None	-	1	Mouse	8.7	pKd	=	8.7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	830	20	12	7	-0.5	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4852297	184821	0	None	-	1	Mouse	8.7	pKd	=	8.7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	830	20	12	7	-0.5	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	122184635	122408	0	None	-2	4	Human	8.0	pKd	=	8	Functional	Antagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT-II-induced intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAntagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT-II-induced intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600916	122408	0	None	-2	4	Human	8.0	pKd	=	8	Functional	Antagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT-II-induced intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAntagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT-II-induced intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	145951083	162952	0	None	-	0	Mouse	8.0	pKd	=	8	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	1033	15	12	10	-0.4	C[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.8b00684
	CHEMBL4175108	162952	0	None	-	0	Mouse	8.0	pKd	=	8	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	1033	15	12	10	-0.4	C[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.8b00684
	164620129	185723	0	None	-	0	Mouse	8.0	pKd	=	8	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	813	20	9	7	1.1	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4866219	185723	0	None	-	0	Mouse	8.0	pKd	=	8	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	813	20	9	7	1.1	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	164613340	184696	0	None	-	0	Mouse	7.0	pKd	=	7	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	765	20	11	7	0.7	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4850510	184696	0	None	-	0	Mouse	7.0	pKd	=	7	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	765	20	11	7	0.7	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	164626062	186576	0	None	-	0	Mouse	7.0	pKd	=	7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	795	18	9	6	3.2	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4878799	186576	0	None	-	0	Mouse	7.0	pKd	=	7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	795	18	9	6	3.2	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	162645080	179426	0	None	-	1	Mouse	6.0	pKd	=	6	Functional	Antagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL	976	12	9	10	-0.9	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)CN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acsmedchemlett.9b00641
	CHEMBL4740561	179426	0	None	-	1	Mouse	6.0	pKd	=	6	Functional	Antagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL	976	12	9	10	-0.9	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)CN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acsmedchemlett.9b00641
	164619091	186162	0	None	-	1	Mouse	6.0	pKd	=	6	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	737	20	9	7	1.6	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4872732	186162	0	None	-	1	Mouse	6.0	pKd	=	6	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	737	20	9	7	1.6	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	164625782	186457	0	None	-	0	Mouse	6.0	pKd	=	6	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	871	18	9	6	2.7	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4876953	186457	0	None	-	0	Mouse	6.0	pKd	=	6	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	871	18	9	6	2.7	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	145957551	162240	0	None	-	1	Mouse	7.9	pKd	=	7.9	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	1015	17	13	11	-1.5	CCCC[C@@H]1NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.8b00684
	CHEMBL4163787	162240	0	None	-	1	Mouse	7.9	pKd	=	7.9	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	1015	17	13	11	-1.5	CCCC[C@@H]1NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.8b00684
	162649541	180031	0	None	-	0	Mouse	6.9	pKd	=	6.9	Functional	Antagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL	963	12	9	10	-0.8	C[C@@H]1NC(=O)CN(CCN)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acsmedchemlett.9b00641
	CHEMBL4747778	180031	0	None	-	0	Mouse	6.9	pKd	=	6.9	Functional	Antagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL	963	12	9	10	-0.8	C[C@@H]1NC(=O)CN(CCN)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acsmedchemlett.9b00641
	162662360	181447	0	None	-	2	Mouse	6.9	pKd	=	6.9	Functional	Antagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL	948	11	9	10	-0.8	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)CN(Cc2ccccc2)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acsmedchemlett.9b00641
	CHEMBL4764556	181447	0	None	-	2	Mouse	6.9	pKd	=	6.9	Functional	Antagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL	948	11	9	10	-0.8	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)CN(Cc2ccccc2)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acsmedchemlett.9b00641
	164612091	184575	0	None	-	1	Mouse	6.9	pKd	=	6.9	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	813	20	9	7	1.1	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4848905	184575	0	None	-	1	Mouse	6.9	pKd	=	6.9	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	813	20	9	7	1.1	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	164613676	185425	0	None	-	1	Mouse	6.9	pKd	=	6.9	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4861645	185425	0	None	-	1	Mouse	6.9	pKd	=	6.9	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	162676380	183342	0	None	-	0	Mouse	5.9	pKd	=	5.9	Functional	Antagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL	948	11	9	10	-1.2	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CN(CCCNC(=N)N)C(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acsmedchemlett.9b00641
	CHEMBL4797774	183342	0	None	-	0	Mouse	5.9	pKd	=	5.9	Functional	Antagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL	948	11	9	10	-1.2	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CN(CCCNC(=N)N)C(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acsmedchemlett.9b00641
	137659851	159413	0	None	-	0	Mouse	5.9	pKd	=	5.9	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assayAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL	949	11	10	10	-1.1	C[C@@H]1NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.7b00856
	CHEMBL4101128	159413	0	None	-	0	Mouse	5.9	pKd	=	5.9	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assayAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL	949	11	10	10	-1.1	C[C@@H]1NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.7b00856
	155548853	173785	0	None	-1380	5	Mouse	5.9	pKd	=	5.9	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	1005	13	10	10	-0.6	CC(C)[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	CHEMBL4538274	173785	0	None	-1380	5	Mouse	5.9	pKd	=	5.9	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	1005	13	10	10	-0.6	CC(C)[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	164619641	185702	0	None	-	0	Mouse	7.8	pKd	=	7.8	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4865888	185702	0	None	-	0	Mouse	7.8	pKd	=	7.8	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	164618743	185566	0	None	-	1	Mouse	7.8	pKd	=	7.8	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	737	20	9	7	1.6	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4863637	185566	0	None	-	1	Mouse	7.8	pKd	=	7.8	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	737	20	9	7	1.6	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	145950765	162809	0	None	-	1	Mouse	6.8	pKd	=	6.8	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	964	12	11	11	-2.2	N=C(N)NCCC[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.8b00684
	CHEMBL4172753	162809	0	None	-	1	Mouse	6.8	pKd	=	6.8	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	964	12	11	11	-2.2	N=C(N)NCCC[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.8b00684
	164624484	185562	0	None	-	0	Mouse	6.8	pKd	=	6.8	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	754	20	12	7	0.1	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4863587	185562	0	None	-	0	Mouse	6.8	pKd	=	6.8	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	754	20	12	7	0.1	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	164620129	185723	0	None	-	0	Mouse	6.8	pKd	=	6.8	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	813	20	9	7	1.1	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4866219	185723	0	None	-	0	Mouse	6.8	pKd	=	6.8	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	813	20	9	7	1.1	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL2373991	210358	0	None	-14	3	Mouse	6.8	pKd	=	6.8	Functional	Antagonistic activity against mouse Melanocortin 3 ReceptorAntagonistic activity against mouse Melanocortin 3 Receptor	ChEMBL		None	None	None		CC[C@@H]1NC(=O)[C@H](N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CSSC[C@H](NC(=O)[C@@H](Cc3ccc(O)cc3)NC(=O)[C@H](CC)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](C)NC(=O)[C@H](CC)NC(=O)[C@@H]3CCCN3C(=O)[C@@H](CC(=O)O)NC1=O)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2	10.1021/jm049620r
	162667883	182390	0	None	-	1	Mouse	5.8	pKd	=	5.8	Functional	Antagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL	976	12	9	10	-0.9	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)CN(Cc2ccccc2)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acsmedchemlett.9b00641
	CHEMBL4785711	182390	0	None	-	1	Mouse	5.8	pKd	=	5.8	Functional	Antagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL	976	12	9	10	-0.9	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)CN(Cc2ccccc2)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acsmedchemlett.9b00641
	137632948	156558	0	None	-	2	Mouse	5.8	pKd	=	5.8	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assayAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4068643	156558	0	None	-	2	Mouse	5.8	pKd	=	5.8	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assayAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.7b00301
	155532232	171681	0	None	-	2	Mouse	5.8	pKd	=	5.8	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	992	12	11	11	-1.5	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	CHEMBL4466724	171681	0	None	-	2	Mouse	5.8	pKd	=	5.8	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	992	12	11	11	-1.5	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	164608927	184433	0	None	-	0	Mouse	5.8	pKd	=	5.8	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	767	18	7	6	4.1	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4846677	184433	0	None	-	0	Mouse	5.8	pKd	=	5.8	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	767	18	7	6	4.1	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	164622957	186090	0	None	-	1	Mouse	5.8	pKd	=	5.8	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4871777	186090	0	None	-	1	Mouse	5.8	pKd	=	5.8	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL501679	214120	0	None	-	3	Mouse	6.8	pKd	=	6.8	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as effect on MT2 peptide-induced response by CRE/beta-galactosidase reporter gene assayAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as effect on MT2 peptide-induced response by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	145949639	162733	0	None	-	0	Mouse	7.7	pKd	=	7.7	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	1049	16	13	11	-1.5	N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC1=O	10.1021/acs.jmedchem.8b00684
	CHEMBL4171666	162733	0	None	-	0	Mouse	7.7	pKd	=	7.7	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	1049	16	13	11	-1.5	N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC1=O	10.1021/acs.jmedchem.8b00684
	164625246	186009	0	None	-	0	Mouse	7.7	pKd	=	7.7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	726	20	10	7	0.9	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4870667	186009	0	None	-	0	Mouse	7.7	pKd	=	7.7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	726	20	10	7	0.9	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	137654791	158894	0	None	-	0	Mouse	5.7	pKd	=	5.7	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assayAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL	1053	14	10	10	0.0	N=C(N)NCCC[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.7b00856
	CHEMBL4095539	158894	0	None	-	0	Mouse	5.7	pKd	=	5.7	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assayAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL	1053	14	10	10	0.0	N=C(N)NCCC[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.7b00856
	CHEMBL264190	210585	1	None	-35	8	Mouse	6.7	pKd	=	6.7	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as effect on MT2 peptide-induced response by CRE/beta-galactosidase reporter gene assayAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as effect on MT2 peptide-induced response by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	CHEMBL454736	213974	0	None	-	2	Mouse	6.7	pKd	=	6.7	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as effect on MT2 peptide-induced response by CRE/beta-galactosidase reporter gene assayAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as effect on MT2 peptide-induced response by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	145956526	162168	0	None	-	0	Mouse	6.7	pKd	=	6.7	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	929	13	10	10	-0.8	CCCC[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CN)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.8b00684
	CHEMBL4162603	162168	0	None	-	0	Mouse	6.7	pKd	=	6.7	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	929	13	10	10	-0.8	CCCC[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CN)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.8b00684
	145960041	162262	0	None	-	0	Mouse	6.7	pKd	=	6.7	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	945	14	11	11	-1.8	CCCC[C@@H]1NC(=O)[C@H](CO)NC(=O)[C@H](CN)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.8b00684
	CHEMBL4164111	162262	0	None	-	0	Mouse	6.7	pKd	=	6.7	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	945	14	11	11	-1.8	CCCC[C@@H]1NC(=O)[C@H](CO)NC(=O)[C@H](CN)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.8b00684
	137638391	156834	0	None	-	0	Mouse	6.7	pKd	=	6.7	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assayAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL	948	11	10	10	-1.1	C[C@@H]1NC(=O)[C@@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.7b00856
	CHEMBL4071633	156834	0	None	-	0	Mouse	6.7	pKd	=	6.7	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assayAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL	948	11	10	10	-1.1	C[C@@H]1NC(=O)[C@@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.7b00856
	164608927	184433	0	None	-	0	Mouse	6.7	pKd	=	6.7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	767	18	7	6	4.1	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4846677	184433	0	None	-	0	Mouse	6.7	pKd	=	6.7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	767	18	7	6	4.1	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	164613114	185229	0	None	-	0	Mouse	6.7	pKd	=	6.7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4858442	185229	0	None	-	0	Mouse	6.7	pKd	=	6.7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	164623350	185875	0	None	-	0	Mouse	6.7	pKd	=	6.7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4868611	185875	0	None	-	0	Mouse	6.7	pKd	=	6.7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	164628715	186473	0	None	-	0	Mouse	6.7	pKd	=	6.7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	806	18	8	6	3.9	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4877266	186473	0	None	-	0	Mouse	6.7	pKd	=	6.7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	806	18	8	6	3.9	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	137642804	158347	0	None	-	1	Mouse	5.7	pKd	=	5.7	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assayAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	832	18	8	6	2.2	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4089759	158347	0	None	-	1	Mouse	5.7	pKd	=	5.7	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assayAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	832	18	8	6	2.2	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	137631920	156412	0	None	-	0	Mouse	5.7	pKd	=	5.7	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assayAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL	976	12	9	9	0.9	CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O	10.1021/acs.jmedchem.7b00856
	CHEMBL4066929	156412	0	None	-	0	Mouse	5.7	pKd	=	5.7	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assayAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL	976	12	9	9	0.9	CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O	10.1021/acs.jmedchem.7b00856
	137632506	156500	0	None	-	0	Mouse	5.7	pKd	=	5.7	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assayAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL	1049	12	10	9	1.6	C[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.7b00856
	CHEMBL4067947	156500	0	None	-	0	Mouse	5.7	pKd	=	5.7	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assayAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL	1049	12	10	9	1.6	C[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.7b00856
	164616496	185368	0	None	-	1	Mouse	5.7	pKd	=	5.7	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	806	18	8	6	3.9	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4860703	185368	0	None	-	1	Mouse	5.7	pKd	=	5.7	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	806	18	8	6	3.9	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	164623596	185450	0	None	-	0	Mouse	5.7	pKd	=	5.7	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	843	18	7	6	3.5	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4862028	185450	0	None	-	0	Mouse	5.7	pKd	=	5.7	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	843	18	7	6	3.5	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	164626062	186576	0	None	-	0	Mouse	5.7	pKd	=	5.7	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	795	18	9	6	3.2	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4878799	186576	0	None	-	0	Mouse	5.7	pKd	=	5.7	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	795	18	9	6	3.2	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL2370695	209889	0	None	-	2	Mouse	5.7	pKd	=	5.7	Functional	Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)O)NC(=O)[C@@H](Cc2ccccc2)NC1=O	10.1021/jm0303608
	164613361	184753	0	None	-	1	Mouse	8.6	pKd	=	8.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4851302	184753	0	None	-	1	Mouse	8.6	pKd	=	8.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	164610096	184837	0	None	-	1	Mouse	8.6	pKd	=	8.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	813	20	9	7	1.1	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4852476	184837	0	None	-	1	Mouse	8.6	pKd	=	8.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	813	20	9	7	1.1	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL2323794	209497	0	None	-	3	Mouse	7.6	pKd	=	7.6	Functional	Antagonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAntagonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCNC(=N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm301253y
	164620572	185747	0	None	-	0	Mouse	7.6	pKd	=	7.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	802	20	10	7	0.4	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4866496	185747	0	None	-	0	Mouse	7.6	pKd	=	7.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	802	20	10	7	0.4	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	164625782	186457	0	None	-	0	Mouse	7.6	pKd	=	7.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	871	18	9	6	2.7	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4876953	186457	0	None	-	0	Mouse	7.6	pKd	=	7.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	871	18	9	6	2.7	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	145959370	161983	0	None	-	1	Mouse	6.6	pKd	=	6.6	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	959	14	11	11	-2.3	CCCC[C@@H]1NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.8b00684
	CHEMBL4159541	161983	0	None	-	1	Mouse	6.6	pKd	=	6.6	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	959	14	11	11	-2.3	CCCC[C@@H]1NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.8b00684
	164613712	185325	0	None	-	1	Mouse	6.6	pKd	=	6.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	958	18	8	6	2.8	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4860080	185325	0	None	-	1	Mouse	6.6	pKd	=	6.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	958	18	8	6	2.8	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	164623596	185450	0	None	-	0	Mouse	6.6	pKd	=	6.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	843	18	7	6	3.5	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4862028	185450	0	None	-	0	Mouse	6.6	pKd	=	6.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	843	18	7	6	3.5	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	10101361	155679	0	None	-	4	Mouse	5.6	pKd	=	5.6	Functional	Agonist activity of compound in mouse Melanocortin-3 receptor (mMC3R)Agonist activity of compound in mouse Melanocortin-3 receptor (mMC3R)	ChEMBL	717	16	8	6	2.4	CC(=O)Nc1cc2ccccc2cc1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	CHEMBL405174	155679	0	None	-	4	Mouse	5.6	pKd	=	5.6	Functional	Agonist activity of compound in mouse Melanocortin-3 receptor (mMC3R)Agonist activity of compound in mouse Melanocortin-3 receptor (mMC3R)	ChEMBL	717	16	8	6	2.4	CC(=O)Nc1cc2ccccc2cc1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	162647356	179656	0	None	-	0	Mouse	5.6	pKd	=	5.6	Functional	Antagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL	948	11	9	10	-1.2	CN1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCC[C@@H]2C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CN)C1=O	10.1021/acsmedchemlett.9b00641
	CHEMBL4743564	179656	0	None	-	0	Mouse	5.6	pKd	=	5.6	Functional	Antagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL	948	11	9	10	-1.2	CN1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCC[C@@H]2C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CN)C1=O	10.1021/acsmedchemlett.9b00641
	137633477	156571	0	None	-	1	Mouse	5.6	pKd	=	5.6	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assayAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4068777	156571	0	None	-	1	Mouse	5.6	pKd	=	5.6	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assayAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.7b00301
	137646614	157514	0	None	-	2	Mouse	5.6	pKd	=	5.6	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assayAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	822	18	9	7	0.9	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4080138	157514	0	None	-	2	Mouse	5.6	pKd	=	5.6	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assayAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	822	18	9	7	0.9	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.7b00301
	137646086	157870	0	None	-	1	Mouse	5.6	pKd	=	5.6	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assayAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	908	19	8	6	3.8	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4084136	157870	0	None	-	1	Mouse	5.6	pKd	=	5.6	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assayAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	908	19	8	6	3.8	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	164615544	184640	0	None	-	0	Mouse	5.6	pKd	=	5.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	871	18	9	6	2.7	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4849756	184640	0	None	-	0	Mouse	5.6	pKd	=	5.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	871	18	9	6	2.7	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL502093	214126	0	None	-	3	Mouse	7.5	pKd	=	7.5	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as effect on MT2 peptide-induced response by CRE/beta-galactosidase reporter gene assayAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as effect on MT2 peptide-induced response by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Br)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	CHEMBL103817	208436	0	None	-100	4	Mouse	6.5	pKd	=	6.5	Functional	Agonist activity of compound towards mouse Melanocortin-3 receptor (mMC3R); partial agonistAgonist activity of compound towards mouse Melanocortin-3 receptor (mMC3R); partial agonist	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	122184633	122406	0	None	-1	4	Human	8.5	pKd	=	8.5	Functional	Antagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT-II-induced intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAntagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT-II-induced intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600914	122406	0	None	-1	4	Human	8.5	pKd	=	8.5	Functional	Antagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT-II-induced intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAntagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT-II-induced intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	164610510	184571	0	None	-	1	Mouse	8.5	pKd	=	8.5	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	917	20	11	7	-0.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4848870	184571	0	None	-	1	Mouse	8.5	pKd	=	8.5	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	917	20	11	7	-0.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	164612091	184575	0	None	-	1	Mouse	8.5	pKd	=	8.5	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	813	20	9	7	1.1	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4848905	184575	0	None	-	1	Mouse	8.5	pKd	=	8.5	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	813	20	9	7	1.1	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	164613261	184579	0	None	-	1	Mouse	8.5	pKd	=	8.5	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	889	20	9	7	0.5	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4848948	184579	0	None	-	1	Mouse	8.5	pKd	=	8.5	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	889	20	9	7	0.5	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	127035019	136411	0	None	-	1	Mouse	8.5	pKd	=	8.5	Functional	Partial agonist activity at mouse MC3 receptor expressed in HEK293 cells assessed as NDP-MSH induced response by cAMP alpha screen based schild analysisPartial agonist activity at mouse MC3 receptor expressed in HEK293 cells assessed as NDP-MSH induced response by cAMP alpha screen based schild analysis	ChEMBL	1074	17	14	11	0.1	CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1016/j.bmcl.2015.10.095
	CHEMBL3735607	136411	0	None	-	1	Mouse	8.5	pKd	=	8.5	Functional	Partial agonist activity at mouse MC3 receptor expressed in HEK293 cells assessed as NDP-MSH induced response by cAMP alpha screen based schild analysisPartial agonist activity at mouse MC3 receptor expressed in HEK293 cells assessed as NDP-MSH induced response by cAMP alpha screen based schild analysis	ChEMBL	1074	17	14	11	0.1	CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1016/j.bmcl.2015.10.095
	CHEMBL413573	213052	0	None	1	4	Human	8.4	pKd	=	8.4	Functional	Activity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulation	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](C(C)C)NC1=O	10.1021/jm0510326
	132938008	159489	0	None	-1659	5	Mouse	6.5	pKd	=	6.5	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assayAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL	948	11	10	10	-1.1	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.7b00856
	CHEMBL4102048	159489	0	None	-1659	5	Mouse	6.5	pKd	=	6.5	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assayAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL	948	11	10	10	-1.1	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.7b00856
	145952946	162461	0	None	-	0	Mouse	7.5	pKd	=	7.5	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	999	16	12	10	-0.5	CCCC[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.8b00684
	CHEMBL4167239	162461	0	None	-	0	Mouse	7.5	pKd	=	7.5	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	999	16	12	10	-0.5	CCCC[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.8b00684
	145954663	162633	0	None	-	0	Mouse	7.5	pKd	=	7.5	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	985	15	12	10	-0.9	CCCC[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.8b00684
	CHEMBL4169872	162633	0	None	-	0	Mouse	7.5	pKd	=	7.5	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	985	15	12	10	-0.9	CCCC[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.8b00684
	164613261	184579	0	None	-	1	Mouse	7.5	pKd	=	7.5	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	889	20	9	7	0.5	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4848948	184579	0	None	-	1	Mouse	7.5	pKd	=	7.5	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	889	20	9	7	0.5	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	132938008	159489	0	None	-1659	5	Mouse	6.5	pKd	=	6.5	Functional	Antagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL	948	11	10	10	-1.1	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acsmedchemlett.9b00641
	CHEMBL4102048	159489	0	None	-1659	5	Mouse	6.5	pKd	=	6.5	Functional	Antagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL	948	11	10	10	-1.1	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acsmedchemlett.9b00641
	145958585	162315	0	None	-	0	Mouse	6.5	pKd	=	6.5	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	931	13	11	11	-2.2	CCCC[C@@H]1NC(=O)[C@H](CO)NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.8b00684
	CHEMBL4164846	162315	0	None	-	0	Mouse	6.5	pKd	=	6.5	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	931	13	11	11	-2.2	CCCC[C@@H]1NC(=O)[C@H](CO)NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.8b00684
	145973163	163060	0	None	-	0	Mouse	6.5	pKd	=	6.5	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	1007	14	11	11	-1.9	N=C(N)NCCC[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.8b00684
	CHEMBL4176668	163060	0	None	-	0	Mouse	6.5	pKd	=	6.5	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	1007	14	11	11	-1.9	N=C(N)NCCC[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.8b00684
	155561116	174949	0	None	-208	5	Mouse	6.5	pKd	=	6.5	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	964	11	11	11	-1.4	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	CHEMBL4566163	174949	0	None	-208	5	Mouse	6.5	pKd	=	6.5	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	964	11	11	11	-1.4	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	137633477	156571	0	None	-	1	Mouse	6.5	pKd	=	6.5	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4068777	156571	0	None	-	1	Mouse	6.5	pKd	=	6.5	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	162653604	180471	0	None	-	0	Mouse	5.5	pKd	=	5.5	Functional	Antagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL	948	11	9	10	-0.8	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)CN(Cc2ccccc2)C1=O	10.1021/acsmedchemlett.9b00641
	CHEMBL4753150	180471	0	None	-	0	Mouse	5.5	pKd	=	5.5	Functional	Antagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL	948	11	9	10	-0.8	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)CN(Cc2ccccc2)C1=O	10.1021/acsmedchemlett.9b00641
	164625246	186009	0	None	-	0	Mouse	5.5	pKd	=	5.5	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	726	20	10	7	0.9	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4870667	186009	0	None	-	0	Mouse	5.5	pKd	=	5.5	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	726	20	10	7	0.9	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	137656661	159701	0	None	-	0	Mouse	6.5	pKd	=	6.5	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assayAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL	1000	12	10	10	-0.1	C[C@@H]1NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.7b00856
	CHEMBL4104582	159701	0	None	-	0	Mouse	6.5	pKd	=	6.5	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assayAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL	1000	12	10	10	-0.1	C[C@@H]1NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.7b00856
	CHEMBL501394	214114	0	None	-	3	Mouse	7.4	pKd	=	7.4	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as effect on MT2 peptide-induced response by CRE/beta-galactosidase reporter gene assayAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as effect on MT2 peptide-induced response by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)c(Cl)c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	CHEMBL322610	211211	0	None	-	4	Mouse	7.4	pKd	=	7.4	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as effect on MT2 peptide-induced response by CRE/beta-galactosidase reporter gene assayAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as effect on MT2 peptide-induced response by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	164610510	184571	0	None	-	1	Mouse	7.4	pKd	=	7.4	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	917	20	11	7	-0.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4848870	184571	0	None	-	1	Mouse	7.4	pKd	=	7.4	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	917	20	11	7	-0.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	164612217	184821	0	None	-	1	Mouse	7.4	pKd	=	7.4	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	830	20	12	7	-0.5	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4852297	184821	0	None	-	1	Mouse	7.4	pKd	=	7.4	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	830	20	12	7	-0.5	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	137639030	156921	0	None	-	0	Mouse	6.4	pKd	=	6.4	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assayAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL	963	11	10	10	-0.7	C[C@@H]1NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.7b00856
	CHEMBL4072662	156921	0	None	-	0	Mouse	6.4	pKd	=	6.4	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assayAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL	963	11	10	10	-0.7	C[C@@H]1NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.7b00856
	137659513	159226	0	None	-	1	Mouse	5.4	pKd	=	5.4	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assayAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4099096	159226	0	None	-	1	Mouse	5.4	pKd	=	5.4	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assayAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.7b00301
	155546131	173506	0	None	-15	5	Mouse	5.4	pKd	=	5.4	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	929	9	8	10	-0.4	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	CHEMBL4531291	173506	0	None	-15	5	Mouse	5.4	pKd	=	5.4	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	929	9	8	10	-0.4	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	44445085	97045	0	None	1	4	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT2 induced intracellular cAMP accumulationAntagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT2 induced intracellular cAMP accumulation	ChEMBL	879	9	11	9	1.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](N)CCCCC(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL267265	97045	0	None	1	4	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT2 induced intracellular cAMP accumulationAntagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT2 induced intracellular cAMP accumulation	ChEMBL	879	9	11	9	1.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](N)CCCCC(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	164617040	185285	0	None	-	1	Mouse	8.3	pKd	=	8.3	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	765	20	11	7	0.7	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4859395	185285	0	None	-	1	Mouse	8.3	pKd	=	8.3	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	765	20	11	7	0.7	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	164613676	185425	0	None	-	1	Mouse	8.3	pKd	=	8.3	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4861645	185425	0	None	-	1	Mouse	8.3	pKd	=	8.3	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	164624484	185562	0	None	-	0	Mouse	8.3	pKd	=	8.3	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	754	20	12	7	0.1	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4863587	185562	0	None	-	0	Mouse	8.3	pKd	=	8.3	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	754	20	12	7	0.1	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL266417	210660	0	None	-83	6	Human	8.3	pKd	=	8.3	Functional	Evaluated for partial agonistic activity at cloned mammalian Melanocortin 3 receptorEvaluated for partial agonistic activity at cloned mammalian Melanocortin 3 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm00018a005
	CHEMBL428801	213449	0	None	-26	5	Human	8.3	pKd	=	8.3	Functional	Evaluated for partial agonistic activity at cloned mammalian Melanocortin 3 receptorEvaluated for partial agonistic activity at cloned mammalian Melanocortin 3 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(I)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm00018a005
	CHEMBL3577981	211726	1	None	-245	5	Mouse	6.3	pKd	=	6.3	Functional	Antagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acsmedchemlett.9b00641
	145952883	162391	0	None	-	0	Mouse	6.3	pKd	=	6.3	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	973	15	11	11	-1.9	CCCC[C@@H]1NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.8b00684
	CHEMBL4166050	162391	0	None	-	0	Mouse	6.3	pKd	=	6.3	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	973	15	11	11	-1.9	CCCC[C@@H]1NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.8b00684
	CHEMBL3577981	211726	1	None	-245	5	Mouse	6.3	pKd	=	6.3	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assayAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.7b00856
	164613712	185325	0	None	-	1	Mouse	6.3	pKd	=	6.3	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	958	18	8	6	2.8	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4860080	185325	0	None	-	1	Mouse	6.3	pKd	=	6.3	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	958	18	8	6	2.8	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	164616496	185368	0	None	-	1	Mouse	6.3	pKd	=	6.3	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	806	18	8	6	3.9	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4860703	185368	0	None	-	1	Mouse	6.3	pKd	=	6.3	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	806	18	8	6	3.9	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	164619441	186122	0	None	-	0	Mouse	6.3	pKd	=	6.3	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	854	18	6	6	4.2	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4872238	186122	0	None	-	0	Mouse	6.3	pKd	=	6.3	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	854	18	6	6	4.2	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	137657385	159742	0	None	-	1	Mouse	5.3	pKd	=	5.3	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assayAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	867	21	11	7	0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4105142	159742	0	None	-	1	Mouse	5.3	pKd	=	5.3	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assayAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assay	ChEMBL	867	21	11	7	0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL322610	211211	0	None	-	4	Mouse	7.3	pKd	=	7.3	Functional	Agonist activity of compound towards mouse Melanocortin-3 receptor (mMC3R)Agonist activity of compound towards mouse Melanocortin-3 receptor (mMC3R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	CHEMBL3600912	211798	0	None	-2	4	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT-II-induced intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAntagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT-II-induced intracellular cAMP accumulation using [3H]-cAMP by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	164619091	186162	0	None	-	1	Mouse	8.2	pKd	=	8.2	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	737	20	9	7	1.6	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4872732	186162	0	None	-	1	Mouse	8.2	pKd	=	8.2	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	737	20	9	7	1.6	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	145951686	162932	0	None	-	0	Mouse	7.2	pKd	=	7.2	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	979	13	11	11	-1.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CN)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.8b00684
	CHEMBL4174761	162932	0	None	-	0	Mouse	7.2	pKd	=	7.2	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	979	13	11	11	-1.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CN)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.8b00684
	164610096	184837	0	None	-	1	Mouse	7.2	pKd	=	7.2	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	813	20	9	7	1.1	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4852476	184837	0	None	-	1	Mouse	7.2	pKd	=	7.2	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	813	20	9	7	1.1	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	145951904	162915	0	None	-	0	Mouse	6.2	pKd	=	6.2	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	957	14	10	10	-0.9	CCCC[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.8b00684
	CHEMBL4174361	162915	0	None	-	0	Mouse	6.2	pKd	=	6.2	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	957	14	10	10	-0.9	CCCC[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.8b00684
	137649684	157114	0	None	-	0	Mouse	6.2	pKd	=	6.2	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assayAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL	992	13	11	11	-2.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.7b00856
	CHEMBL4075125	157114	0	None	-	0	Mouse	6.2	pKd	=	6.2	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assayAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL	992	13	11	11	-2.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.7b00856
	164618743	185566	0	None	-	1	Mouse	6.2	pKd	=	6.2	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	737	20	9	7	1.6	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4863637	185566	0	None	-	1	Mouse	6.2	pKd	=	6.2	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	737	20	9	7	1.6	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	164620572	185747	0	None	-	0	Mouse	6.2	pKd	=	6.2	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	802	20	10	7	0.4	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4866496	185747	0	None	-	0	Mouse	6.2	pKd	=	6.2	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	802	20	10	7	0.4	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	127047624	139871	0	None	-123	3	Mouse	6.1	pKd	=	6.1	Functional	Antagonist activity against mouse MC3R expressed in HEK293 cells assessed as NDP-MSH-stimulated cAMP accumulation incubated for 2 hrs by alphascreen assayAntagonist activity against mouse MC3R expressed in HEK293 cells assessed as NDP-MSH-stimulated cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	1054	36	12	13	-0.1	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL3799408	139871	0	None	-123	3	Mouse	6.1	pKd	=	6.1	Functional	Antagonist activity against mouse MC3R expressed in HEK293 cells assessed as NDP-MSH-stimulated cAMP accumulation incubated for 2 hrs by alphascreen assayAntagonist activity against mouse MC3R expressed in HEK293 cells assessed as NDP-MSH-stimulated cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	1054	36	12	13	-0.1	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(N)=O	10.1021/acs.jmedchem.5b01894
	162650385	180047	0	None	-	1	Mouse	7.1	pKd	=	7.1	Functional	Antagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL	948	11	9	10	-0.8	C[C@@H]1NC(=O)[C@H](CN)NC(=O)CN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acsmedchemlett.9b00641
	CHEMBL4747952	180047	0	None	-	1	Mouse	7.1	pKd	=	7.1	Functional	Antagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assayAntagonist activity at mouse MC3R assessed as antagonist potency by alphascreen cAMP assay	ChEMBL	948	11	9	10	-0.8	C[C@@H]1NC(=O)[C@H](CN)NC(=O)CN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acsmedchemlett.9b00641
	145957356	161964	0	None	-	0	Mouse	7.1	pKd	=	7.1	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	1035	15	13	11	-1.9	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC1=O	10.1021/acs.jmedchem.8b00684
	CHEMBL4159229	161964	0	None	-	0	Mouse	7.1	pKd	=	7.1	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	1035	15	13	11	-1.9	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC1=O	10.1021/acs.jmedchem.8b00684
	145953129	162416	0	None	-	0	Mouse	7.1	pKd	=	7.1	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	1001	16	13	11	-1.9	CCCC[C@@H]1NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.8b00684
	CHEMBL4166449	162416	0	None	-	0	Mouse	7.1	pKd	=	7.1	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	1001	16	13	11	-1.9	CCCC[C@@H]1NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.8b00684
	145954673	162647	0	None	-	1	Mouse	7.1	pKd	=	7.1	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	915	12	10	10	-1.2	CCCC[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.8b00684
	CHEMBL4170160	162647	0	None	-	1	Mouse	7.1	pKd	=	7.1	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	915	12	10	10	-1.2	CCCC[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O	10.1021/acs.jmedchem.8b00684
	145951839	162851	0	None	-	1	Mouse	7.1	pKd	=	7.1	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	963	12	10	10	-0.7	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.8b00684
	CHEMBL4173301	162851	0	None	-	1	Mouse	7.1	pKd	=	7.1	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysisAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as reduction in NDP-MSH-induced response incubated for 2 hrs by AlphaScreen cAMP assay based Schild analysis	ChEMBL	963	12	10	10	-0.7	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.8b00684
	164613361	184753	0	None	-	1	Mouse	7.1	pKd	=	7.1	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4851302	184753	0	None	-	1	Mouse	7.1	pKd	=	7.1	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	137632217	156278	0	None	-	0	Mouse	6.1	pKd	=	6.1	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assayAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL	900	10	10	10	-2.4	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O	10.1021/acs.jmedchem.7b00856
	CHEMBL4065443	156278	0	None	-	0	Mouse	6.1	pKd	=	6.1	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assayAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation after 2 hrs by AlphaScreen assay	ChEMBL	900	10	10	10	-2.4	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O	10.1021/acs.jmedchem.7b00856
	137633477	156571	0	None	-	1	Mouse	6.1	pKd	=	6.1	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4068777	156571	0	None	-	1	Mouse	6.1	pKd	=	6.1	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	155544852	174915	0	None	-1230	5	Mouse	6.1	pKd	=	6.1	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	977	12	10	10	-0.5	CC(C)[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	CHEMBL4565367	174915	0	None	-1230	5	Mouse	6.1	pKd	=	6.1	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	977	12	10	10	-0.5	CC(C)[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	164613114	185229	0	None	-	0	Mouse	6.1	pKd	=	6.1	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4858442	185229	0	None	-	0	Mouse	6.1	pKd	=	6.1	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	164617040	185285	0	None	-	1	Mouse	6.1	pKd	=	6.1	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	765	20	11	7	0.7	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4859395	185285	0	None	-	1	Mouse	6.1	pKd	=	6.1	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	765	20	11	7	0.7	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	44310103	166623	0	None	-	1	Mouse	8.1	pKd	=	8.1	Functional	Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor	ChEMBL	4237	51	50	66	-10.2	CC(=O)NN[C@H]1CSSSSC[C@@H]2NC(=O)[C@@H]3CSSSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)C(N)=O)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@@H]4CSSSSC[C@H](NC(=O)[C@H](Cc5ccc(O)cc5)NC(=O)[C@H](CSSSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc5c[nH]cn5)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C(C)C)NC1=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N3)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC2=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N4	10.1021/jm0303608
	77231882	166623	0	None	-	1	Mouse	8.1	pKd	=	8.1	Functional	Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor	ChEMBL	4237	51	50	66	-10.2	CC(=O)NN[C@H]1CSSSSC[C@@H]2NC(=O)[C@@H]3CSSSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)C(N)=O)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@@H]4CSSSSC[C@H](NC(=O)[C@H](Cc5ccc(O)cc5)NC(=O)[C@H](CSSSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc5c[nH]cn5)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C(C)C)NC1=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N3)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC2=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N4	10.1021/jm0303608
	CHEMBL428134	166623	0	None	-	1	Mouse	8.1	pKd	=	8.1	Functional	Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor	ChEMBL	4237	51	50	66	-10.2	CC(=O)NN[C@H]1CSSSSC[C@@H]2NC(=O)[C@@H]3CSSSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)C(N)=O)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@@H]4CSSSSC[C@H](NC(=O)[C@H](Cc5ccc(O)cc5)NC(=O)[C@H](CSSSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc5c[nH]cn5)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C(C)C)NC1=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N3)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC2=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N4	10.1021/jm0303608
	127047336	139773	0	None	-33	4	Mouse	6.1	pKd	=	6.1	Functional	Antagonist activity against mouse MC3R expressed in HEK293 cells assessed as NDP-MSH-stimulated cAMP accumulation incubated for 2 hrs by alphascreen assayAntagonist activity against mouse MC3R expressed in HEK293 cells assessed as NDP-MSH-stimulated cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	1730	54	21	19	1.1	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL3798768	139773	0	None	-33	4	Mouse	6.1	pKd	=	6.1	Functional	Antagonist activity against mouse MC3R expressed in HEK293 cells assessed as NDP-MSH-stimulated cAMP accumulation incubated for 2 hrs by alphascreen assayAntagonist activity against mouse MC3R expressed in HEK293 cells assessed as NDP-MSH-stimulated cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	1730	54	21	19	1.1	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	127046262	139795	0	None	-45	3	Mouse	6.1	pKd	=	6.1	Functional	Antagonist activity against mouse MC3R expressed in HEK293 cells assessed as NDP-MSH-stimulated cAMP accumulation incubated for 2 hrs by alphascreen assayAntagonist activity against mouse MC3R expressed in HEK293 cells assessed as NDP-MSH-stimulated cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	1012	35	12	13	-0.3	N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)COCC(=O)NCCCOCCOCCOCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL3798912	139795	0	None	-45	3	Mouse	6.1	pKd	=	6.1	Functional	Antagonist activity against mouse MC3R expressed in HEK293 cells assessed as NDP-MSH-stimulated cAMP accumulation incubated for 2 hrs by alphascreen assayAntagonist activity against mouse MC3R expressed in HEK293 cells assessed as NDP-MSH-stimulated cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL	1012	35	12	13	-0.3	N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)COCC(=O)NCCCOCCOCCOCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL103817	208436	0	None	-100	4	Mouse	6.0	pKd	=	6.0	Functional	Antagonist activity against mouse MC3R expressed in HEK293 cells assessed as NDP-MSH-stimulated cAMP accumulation incubated for 2 hrs by alphascreen assayAntagonist activity against mouse MC3R expressed in HEK293 cells assessed as NDP-MSH-stimulated cAMP accumulation incubated for 2 hrs by alphascreen assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	164619641	185702	0	None	-	0	Mouse	9.0	pKi	=	9	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4865888	185702	0	None	-	0	Mouse	9.0	pKi	=	9	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	164613340	184696	0	None	-	0	Mouse	8.8	pKi	=	8.8	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	765	20	11	7	0.7	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4850510	184696	0	None	-	0	Mouse	8.8	pKi	=	8.8	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	765	20	11	7	0.7	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	127035019	136411	0	None	-	1	Mouse	8.8	pKi	=	8.8	Functional	Partial agonist activity at mouse MC3 receptor expressed in HEK293 cells assessed as NDP-MSH induced response by cAMP alpha screen based schild analysisPartial agonist activity at mouse MC3 receptor expressed in HEK293 cells assessed as NDP-MSH induced response by cAMP alpha screen based schild analysis	ChEMBL	1074	17	14	11	0.1	CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1016/j.bmcl.2015.10.095
	CHEMBL3735607	136411	0	None	-	1	Mouse	8.8	pKi	=	8.8	Functional	Partial agonist activity at mouse MC3 receptor expressed in HEK293 cells assessed as NDP-MSH induced response by cAMP alpha screen based schild analysisPartial agonist activity at mouse MC3 receptor expressed in HEK293 cells assessed as NDP-MSH induced response by cAMP alpha screen based schild analysis	ChEMBL	1074	17	14	11	0.1	CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1016/j.bmcl.2015.10.095
	164620129	185723	0	None	-	0	Mouse	8.0	pKi	=	8	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	813	20	9	7	1.1	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4866219	185723	0	None	-	0	Mouse	8.0	pKi	=	8	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	813	20	9	7	1.1	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	164613340	184696	0	None	-	0	Mouse	7.0	pKi	=	7	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	765	20	11	7	0.7	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4850510	184696	0	None	-	0	Mouse	7.0	pKi	=	7	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	765	20	11	7	0.7	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	164626062	186576	0	None	-	0	Mouse	7.0	pKi	=	7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	795	18	9	6	3.2	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4878799	186576	0	None	-	0	Mouse	7.0	pKi	=	7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	795	18	9	6	3.2	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	164619091	186162	0	None	-	1	Mouse	6.0	pKi	=	6	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	737	20	9	7	1.6	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4872732	186162	0	None	-	1	Mouse	6.0	pKi	=	6	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	737	20	9	7	1.6	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	164625782	186457	0	None	-	0	Mouse	6.0	pKi	=	6	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	871	18	9	6	2.7	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4876953	186457	0	None	-	0	Mouse	6.0	pKi	=	6	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	871	18	9	6	2.7	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	164612091	184575	0	None	-	1	Mouse	6.9	pKi	=	6.9	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	813	20	9	7	1.1	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4848905	184575	0	None	-	1	Mouse	6.9	pKi	=	6.9	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	813	20	9	7	1.1	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	164613676	185425	0	None	-	1	Mouse	6.9	pKi	=	6.9	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4861645	185425	0	None	-	1	Mouse	6.9	pKi	=	6.9	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	164619641	185702	0	None	-	0	Mouse	7.8	pKi	=	7.8	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4865888	185702	0	None	-	0	Mouse	7.8	pKi	=	7.8	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	164618743	185566	0	None	-	1	Mouse	7.8	pKi	=	7.8	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	737	20	9	7	1.6	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4863637	185566	0	None	-	1	Mouse	7.8	pKi	=	7.8	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	737	20	9	7	1.6	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	164624484	185562	0	None	-	0	Mouse	6.8	pKi	=	6.8	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	754	20	12	7	0.1	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4863587	185562	0	None	-	0	Mouse	6.8	pKi	=	6.8	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	754	20	12	7	0.1	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	164620129	185723	0	None	-	0	Mouse	6.8	pKi	=	6.8	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	813	20	9	7	1.1	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4866219	185723	0	None	-	0	Mouse	6.8	pKi	=	6.8	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	813	20	9	7	1.1	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	164608927	184433	0	None	-	0	Mouse	5.8	pKi	=	5.8	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	767	18	7	6	4.1	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4846677	184433	0	None	-	0	Mouse	5.8	pKi	=	5.8	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	767	18	7	6	4.1	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	164622957	186090	0	None	-	1	Mouse	5.8	pKi	=	5.8	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4871777	186090	0	None	-	1	Mouse	5.8	pKi	=	5.8	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	164612217	184821	0	None	-	1	Mouse	8.7	pKi	=	8.7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	830	20	12	7	-0.5	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4852297	184821	0	None	-	1	Mouse	8.7	pKi	=	8.7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	830	20	12	7	-0.5	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	164613361	184753	0	None	-	1	Mouse	8.6	pKi	=	8.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4851302	184753	0	None	-	1	Mouse	8.6	pKi	=	8.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	164610096	184837	0	None	-	1	Mouse	8.6	pKi	=	8.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	813	20	9	7	1.1	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4852476	184837	0	None	-	1	Mouse	8.6	pKi	=	8.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	813	20	9	7	1.1	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	164625246	186009	0	None	-	0	Mouse	7.7	pKi	=	7.7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	726	20	10	7	0.9	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4870667	186009	0	None	-	0	Mouse	7.7	pKi	=	7.7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	726	20	10	7	0.9	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	164608927	184433	0	None	-	0	Mouse	6.7	pKi	=	6.7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	767	18	7	6	4.1	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4846677	184433	0	None	-	0	Mouse	6.7	pKi	=	6.7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	767	18	7	6	4.1	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	164613114	185229	0	None	-	0	Mouse	6.7	pKi	=	6.7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4858442	185229	0	None	-	0	Mouse	6.7	pKi	=	6.7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	164623350	185875	0	None	-	0	Mouse	6.7	pKi	=	6.7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4868611	185875	0	None	-	0	Mouse	6.7	pKi	=	6.7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	164628715	186473	0	None	-	0	Mouse	6.7	pKi	=	6.7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	806	18	8	6	3.9	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4877266	186473	0	None	-	0	Mouse	6.7	pKi	=	6.7	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	806	18	8	6	3.9	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	164616496	185368	0	None	-	1	Mouse	5.7	pKi	=	5.7	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	806	18	8	6	3.9	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4860703	185368	0	None	-	1	Mouse	5.7	pKi	=	5.7	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	806	18	8	6	3.9	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	164623596	185450	0	None	-	0	Mouse	5.7	pKi	=	5.7	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	843	18	7	6	3.5	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4862028	185450	0	None	-	0	Mouse	5.7	pKi	=	5.7	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	843	18	7	6	3.5	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	164626062	186576	0	None	-	0	Mouse	5.7	pKi	=	5.7	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	795	18	9	6	3.2	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4878799	186576	0	None	-	0	Mouse	5.7	pKi	=	5.7	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	795	18	9	6	3.2	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	164620572	185747	0	None	-	0	Mouse	7.6	pKi	=	7.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	802	20	10	7	0.4	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4866496	185747	0	None	-	0	Mouse	7.6	pKi	=	7.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	802	20	10	7	0.4	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	164625782	186457	0	None	-	0	Mouse	7.6	pKi	=	7.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	871	18	9	6	2.7	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4876953	186457	0	None	-	0	Mouse	7.6	pKi	=	7.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	871	18	9	6	2.7	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	164613712	185325	0	None	-	1	Mouse	6.6	pKi	=	6.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	958	18	8	6	2.8	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4860080	185325	0	None	-	1	Mouse	6.6	pKi	=	6.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	958	18	8	6	2.8	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	164623596	185450	0	None	-	0	Mouse	6.6	pKi	=	6.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	843	18	7	6	3.5	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4862028	185450	0	None	-	0	Mouse	6.6	pKi	=	6.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	843	18	7	6	3.5	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	10101361	155679	0	None	-	4	Mouse	5.6	pKi	=	5.6	Functional	Agonist activity of compound in mouse Melanocortin-3 receptor (mMC3R)Agonist activity of compound in mouse Melanocortin-3 receptor (mMC3R)	ChEMBL	717	16	8	6	2.4	CC(=O)Nc1cc2ccccc2cc1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	CHEMBL405174	155679	0	None	-	4	Mouse	5.6	pKi	=	5.6	Functional	Agonist activity of compound in mouse Melanocortin-3 receptor (mMC3R)Agonist activity of compound in mouse Melanocortin-3 receptor (mMC3R)	ChEMBL	717	16	8	6	2.4	CC(=O)Nc1cc2ccccc2cc1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	164615544	184640	0	None	-	0	Mouse	5.6	pKi	=	5.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	871	18	9	6	2.7	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4849756	184640	0	None	-	0	Mouse	5.6	pKi	=	5.6	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	871	18	9	6	2.7	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL322610	211211	0	None	-	4	Mouse	6.6	pKi	=	6.6	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as effect on MT2 peptide-induced response by CRE/beta-galactosidase reporter gene assayAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as effect on MT2 peptide-induced response by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	CHEMBL501394	214114	0	None	-	3	Mouse	6.6	pKi	=	6.6	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as effect on MT2 peptide-induced response by CRE/beta-galactosidase reporter gene assayAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as effect on MT2 peptide-induced response by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)c(Cl)c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	164610510	184571	0	None	-	1	Mouse	8.5	pKi	=	8.5	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	917	20	11	7	-0.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4848870	184571	0	None	-	1	Mouse	8.5	pKi	=	8.5	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	917	20	11	7	-0.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	164612091	184575	0	None	-	1	Mouse	8.5	pKi	=	8.5	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	813	20	9	7	1.1	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4848905	184575	0	None	-	1	Mouse	8.5	pKi	=	8.5	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	813	20	9	7	1.1	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	164613261	184579	0	None	-	1	Mouse	8.5	pKi	=	8.5	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	889	20	9	7	0.5	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4848948	184579	0	None	-	1	Mouse	8.5	pKi	=	8.5	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	889	20	9	7	0.5	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	127035019	136411	0	None	-	1	Mouse	8.5	pKi	=	8.5	Functional	Partial agonist activity at mouse MC3 receptor expressed in HEK293 cells assessed as NDP-MSH induced response by cAMP alpha screen based schild analysisPartial agonist activity at mouse MC3 receptor expressed in HEK293 cells assessed as NDP-MSH induced response by cAMP alpha screen based schild analysis	ChEMBL	1074	17	14	11	0.1	CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1016/j.bmcl.2015.10.095
	CHEMBL3735607	136411	0	None	-	1	Mouse	8.5	pKi	=	8.5	Functional	Partial agonist activity at mouse MC3 receptor expressed in HEK293 cells assessed as NDP-MSH induced response by cAMP alpha screen based schild analysisPartial agonist activity at mouse MC3 receptor expressed in HEK293 cells assessed as NDP-MSH induced response by cAMP alpha screen based schild analysis	ChEMBL	1074	17	14	11	0.1	CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1016/j.bmcl.2015.10.095
	164613261	184579	0	None	-	1	Mouse	7.5	pKi	=	7.5	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	889	20	9	7	0.5	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4848948	184579	0	None	-	1	Mouse	7.5	pKi	=	7.5	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	889	20	9	7	0.5	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	137633477	156571	0	None	-	1	Mouse	6.5	pKi	=	6.5	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4068777	156571	0	None	-	1	Mouse	6.5	pKi	=	6.5	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	164625246	186009	0	None	-	0	Mouse	5.5	pKi	=	5.5	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	726	20	10	7	0.9	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4870667	186009	0	None	-	0	Mouse	5.5	pKi	=	5.5	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	726	20	10	7	0.9	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL502093	214126	0	None	-	3	Mouse	6.5	pKi	=	6.5	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as effect on MT2 peptide-induced response by CRE/beta-galactosidase reporter gene assayAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as effect on MT2 peptide-induced response by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Br)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	164610510	184571	0	None	-	1	Mouse	7.4	pKi	=	7.4	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	917	20	11	7	-0.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4848870	184571	0	None	-	1	Mouse	7.4	pKi	=	7.4	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	917	20	11	7	-0.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	164612217	184821	0	None	-	1	Mouse	7.4	pKi	=	7.4	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	830	20	12	7	-0.5	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4852297	184821	0	None	-	1	Mouse	7.4	pKi	=	7.4	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	830	20	12	7	-0.5	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	164617040	185285	0	None	-	1	Mouse	8.3	pKi	=	8.3	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	765	20	11	7	0.7	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4859395	185285	0	None	-	1	Mouse	8.3	pKi	=	8.3	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	765	20	11	7	0.7	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	164613676	185425	0	None	-	1	Mouse	8.3	pKi	=	8.3	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4861645	185425	0	None	-	1	Mouse	8.3	pKi	=	8.3	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	164624484	185562	0	None	-	0	Mouse	8.3	pKi	=	8.3	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	754	20	12	7	0.1	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4863587	185562	0	None	-	0	Mouse	8.3	pKi	=	8.3	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	754	20	12	7	0.1	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	164613712	185325	0	None	-	1	Mouse	6.3	pKi	=	6.3	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	958	18	8	6	2.8	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4860080	185325	0	None	-	1	Mouse	6.3	pKi	=	6.3	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	958	18	8	6	2.8	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	164616496	185368	0	None	-	1	Mouse	6.3	pKi	=	6.3	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	806	18	8	6	3.9	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4860703	185368	0	None	-	1	Mouse	6.3	pKi	=	6.3	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	806	18	8	6	3.9	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	164619441	186122	0	None	-	0	Mouse	6.3	pKi	=	6.3	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	854	18	6	6	4.2	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4872238	186122	0	None	-	0	Mouse	6.3	pKi	=	6.3	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	854	18	6	6	4.2	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL454736	213974	0	None	-	2	Mouse	5.3	pKi	=	5.3	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as effect on MT2 peptide-induced response by CRE/beta-galactosidase reporter gene assayAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as effect on MT2 peptide-induced response by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	164619091	186162	0	None	-	1	Mouse	8.2	pKi	=	8.2	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	737	20	9	7	1.6	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4872732	186162	0	None	-	1	Mouse	8.2	pKi	=	8.2	Functional	Antagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	737	20	9	7	1.6	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL501679	214120	0	None	-	3	Mouse	5.2	pKi	=	5.2	Functional	Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as effect on MT2 peptide-induced response by CRE/beta-galactosidase reporter gene assayAntagonist activity at mouse MC3R expressed in HEK293 cells assessed as effect on MT2 peptide-induced response by CRE/beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm800291b
	164610096	184837	0	None	-	1	Mouse	7.2	pKi	=	7.2	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	813	20	9	7	1.1	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4852476	184837	0	None	-	1	Mouse	7.2	pKi	=	7.2	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	813	20	9	7	1.1	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	164618743	185566	0	None	-	1	Mouse	6.2	pKi	=	6.2	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	737	20	9	7	1.6	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4863637	185566	0	None	-	1	Mouse	6.2	pKi	=	6.2	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	737	20	9	7	1.6	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	164620572	185747	0	None	-	0	Mouse	6.2	pKi	=	6.2	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	802	20	10	7	0.4	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4866496	185747	0	None	-	0	Mouse	6.2	pKi	=	6.2	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	802	20	10	7	0.4	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O	10.1021/acs.jmedchem.1c01417
	164613361	184753	0	None	-	1	Mouse	7.1	pKi	=	7.1	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4851302	184753	0	None	-	1	Mouse	7.1	pKi	=	7.1	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	137633477	156571	0	None	-	1	Mouse	6.1	pKi	=	6.1	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4068777	156571	0	None	-	1	Mouse	6.1	pKi	=	6.1	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	164613114	185229	0	None	-	0	Mouse	6.1	pKi	=	6.1	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4858442	185229	0	None	-	0	Mouse	6.1	pKi	=	6.1	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	882	18	8	6	3.3	CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.1c01417
	164617040	185285	0	None	-	1	Mouse	6.1	pKi	=	6.1	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	765	20	11	7	0.7	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	CHEMBL4859395	185285	0	None	-	1	Mouse	6.1	pKi	=	6.1	Functional	Antagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysisAntagonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay based Schild analysis	ChEMBL	765	20	11	7	0.7	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.1c01417
	131839615	212613	26	None	-1	7	Mouse	8.0	pEC50	=	8.0	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	Drug Central		None	None	None		CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	None
	16133835	212613	26	None	-1	7	Mouse	8.0	pEC50	=	8.0	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	Drug Central		None	None	None		CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	None
	CHEMBL407070	212613	26	None	-1	7	Mouse	8.0	pEC50	=	8.0	Functional	Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assayAgonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay	Drug Central		None	None	None		CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	None
	10408	717	28	None	-5	4	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	Drug Central		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	None
	5329	717	28	None	-5	4	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	Drug Central		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	None
	9941379	717	28	None	-5	4	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	Drug Central		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	None
	CHEMBL2070241	717	28	None	-5	4	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	Drug Central		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	None
	DB11653	717	28	None	-5	4	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method	Drug Central		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	None
	6546	3053	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	17482720
	1334	1489	7	None	1	4	Human	8.2	pIC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11150170
	16133814	1489	7	None	1	4	Human	8.2	pIC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11150170
	CHEMBL437050	1489	7	None	1	4	Human	8.2	pIC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11150170
	1341	3054	0	None	-6	3	Human	9.7	pIC50	=	9.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12431055
	1329	313	0	None	-	1	Mouse	6.7	pIC50	None	6.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9454589
	1335	314	0	None	-39	3	Human	7.7	pIC50	None	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9819197

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	1971	2846	38	None	-	30	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2404	2846	38	None	-	30	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543	2846	38	None	-	30	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL445	2846	38	None	-	30	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	DB00540	2846	38	None	-	30	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	216416	111554	48	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL328190	111554	48	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	71496458	115538	87	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL3353410	115538	87	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	135409453	3744	41	None	-	2	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3744	41	None	-	2	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3744	41	None	-	2	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	214	3831	58	None	-	30	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2740	3831	58	None	-	30	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566	3831	58	None	-	30	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	66064	3831	58	None	-	30	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL422	3831	58	None	-	30	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00831	3831	58	None	-	30	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2435	3563	83	None	-	49	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	60149	3563	83	None	-	49	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	98	3563	83	None	-	49	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	CHEMBL12713	3563	83	None	-	49	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	DB06144	3563	83	None	-	49	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	25181577	78190	56	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	574	9	2	9	5.0	CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1	10.1038/s41467-023-40064-9
	CHEMBL2105695	78190	56	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	574	9	2	9	5.0	CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1	10.1038/s41467-023-40064-9
	4046	2466	33	None	-	2	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2466	33	None	-	2	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2466	33	None	-	2	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2466	33	None	-	2	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	176	397	66	None	-6	31	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	2157	397	66	None	-6	31	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	2566	397	66	None	-6	31	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	CHEMBL633	397	66	None	-6	31	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	DB01118	397	66	None	-6	31	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	2351	4269	49	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1008	4269	49	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1257078	4269	49	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	1046	202629	116	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	123	1	1	3	-0.4	NC(=O)c1cnccn1	10.1038/s41467-023-40064-9
	CHEMBL614	202629	116	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	123	1	1	3	-0.4	NC(=O)c1cnccn1	10.1038/s41467-023-40064-9
	156419	935	74	None	-	1	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	3308	935	74	None	-	1	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	647	935	74	None	-	1	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL1201284	935	74	None	-	1	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	DB01012	935	74	None	-	1	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	6	1	1	6.1	C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	4212	198656	82	None	-	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	10.1038/s41467-023-40064-9
	CHEMBL1417019	198656	82	None	-	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	10.1038/s41467-023-40064-9
	CHEMBL58	198656	82	None	-	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	10.1038/s41467-023-40064-9
	41684	31191	105	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	CHEMBL1401	31191	105	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	154257	178595	67	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	178595	67	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	104850	3305	96	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	4150	3305	96	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	743	3305	96	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL111	3305	96	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	DB06155	3305	96	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	24826799	10766	104	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	CHEMBL1171837	10766	104	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	2162	41484	100	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1491	41484	100	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	3926	207218	40	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL92870	207218	40	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	4046	2466	33	None	-	2	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2466	33	None	-	2	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2466	33	None	-	2	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2466	33	None	-	2	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4046	2466	33	None	-	2	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2466	33	None	-	2	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2466	33	None	-	2	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2466	33	None	-	2	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	42890	9393	59	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	497	3	5	10	1.0	CC(=O)[C@]1(O)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](N)[C@H](O)[C@H](C)O2)C1)C(=O)c1ccccc1C3=O	10.1038/s41467-023-40064-9
	CHEMBL1117	9393	59	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	497	3	5	10	1.0	CC(=O)[C@]1(O)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](N)[C@H](O)[C@H](C)O2)C1)C(=O)c1ccccc1C3=O	10.1038/s41467-023-40064-9
	11980903	14460	19	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	22526	14460	19	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	5281035	14460	19	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201303	14460	19	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	5440	28693	37	None	-	9	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1378	28693	37	None	-	9	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	2194	63053	101	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	240	2	0	4	4.2	COc1ccc(-c2cc(=S)ss2)cc1	10.1038/s41467-023-40064-9
	CHEMBL178862	63053	101	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	240	2	0	4	4.2	COc1ccc(-c2cc(=S)ss2)cc1	10.1038/s41467-023-40064-9
	5328940	100188	107	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
	CHEMBL288441	100188	107	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
	1212	1649	50	None	-	66	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	204	1649	50	None	-	66	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	3372	1649	50	None	-	66	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL726	1649	50	None	-	66	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00623	1649	50	None	-	66	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	3380	22758	34	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	313	2	0	4	2.5	CN1C(=O)CN=C(c2ccccc2F)c2cc([N+](=O)[O-])ccc21	10.1038/s41467-023-40064-9
	CHEMBL13280	22758	34	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	313	2	0	4	2.5	CN1C(=O)CN=C(c2ccccc2F)c2cc([N+](=O)[O-])ccc21	10.1038/s41467-023-40064-9
	1427	2000	54	None	-	27	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	357	2000	54	None	-	27	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	3696	2000	54	None	-	27	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL11	2000	54	None	-	27	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00458	2000	54	None	-	27	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	4046	2466	33	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2466	33	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2466	33	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2466	33	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4011	82379	49	None	-	24	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
	CHEMBL21731	82379	49	None	-	24	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
	2726	916	68	None	-186	73	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	621	916	68	None	-186	73	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	83	916	68	None	-186	73	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL71	916	68	None	-186	73	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB00477	916	68	None	-186	73	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2519	776	86	None	-	12	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1038/s41467-023-40064-9
	407	776	86	None	-	12	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1038/s41467-023-40064-9
	463	776	86	None	-	12	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1038/s41467-023-40064-9
	CHEMBL113	776	86	None	-	12	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1038/s41467-023-40064-9
	DB00201	776	86	None	-	12	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1038/s41467-023-40064-9
	11626560	200914	94	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	CHEMBL601719	200914	94	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	11976	917	59	None	-	24	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	667467	917	59	None	-	24	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	CHEMBL908	917	59	None	-	24	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	DB01239	917	59	None	-	24	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	1056	3346	116	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	2405	3346	116	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	77999	3346	116	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	CHEMBL121	3346	116	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	DB00412	3346	116	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	2200	20171	61	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1256819	20171	61	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1305	20171	61	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	25382	9125	37	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL110094	9125	37	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	51755	57376	54	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	454	8	0	4	7.3	Clc1ccc(C(Cn2ccnc2)OCc2ccc(Sc3ccccc3)cc2)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1651990	57376	54	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	454	8	0	4	7.3	Clc1ccc(C(Cn2ccnc2)OCc2ccc(Sc3ccccc3)cc2)c(Cl)c1	10.1038/s41467-023-40064-9
	4236	28065	66	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	273	5	1	2	2.0	NC(=O)C[S+]([O-])C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1373	28065	66	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	273	5	1	2	2.0	NC(=O)C[S+]([O-])C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	103	4122	61	None	-	54	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	4122	61	None	-	54	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	4122	61	None	-	54	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	4122	61	None	-	54	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	4122	61	None	-	54	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	202	1496	77	None	-	33	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	60835	1496	77	None	-	33	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	972	1496	77	None	-	33	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1175	1496	77	None	-	33	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	DB00476	1496	77	None	-	33	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	180	400	56	None	-	40	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	400	56	None	-	40	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	400	56	None	-	40	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	400	56	None	-	40	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	400	56	None	-	40	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	124087	1377	114	None	-	15	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	7157	1377	114	None	-	15	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	814	1377	114	None	-	15	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	CHEMBL1172	1377	114	None	-	15	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	DB00967	1377	114	None	-	15	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	3676	205247	101	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	234	5	1	2	2.6	CCN(CC)CC(=O)Nc1c(C)cccc1C	10.1038/s41467-023-40064-9
	CHEMBL79	205247	101	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	234	5	1	2	2.6	CCN(CC)CC(=O)Nc1c(C)cccc1C	10.1038/s41467-023-40064-9
	216239	23763	118	None	-	7	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	CHEMBL1200485	23763	118	None	-	7	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	CHEMBL1336	23763	118	None	-	7	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	2247	504	81	None	-147	42	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	504	81	None	-147	42	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	504	81	None	-147	42	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	504	81	None	-147	42	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	504	81	None	-147	42	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	26987	946	33	None	-	21	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	6063	946	33	None	-	21	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	671	946	33	None	-	21	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	CHEMBL1626	946	33	None	-	21	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	DB00283	946	33	None	-	21	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	CHEMBL4743867	214010	14	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL		None	None	None		OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1	10.1038/s41467-023-40064-9
	3149	12582	15	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1187011	12582	15	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	1353	1898	93	None	-	86	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559	1898	93	None	-	86	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	86	1898	93	None	-	86	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL54	1898	93	None	-	86	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	DB00502	1898	93	None	-	86	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	4150	785	39	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	5288	785	39	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	644019	785	39	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	CHEMBL190461	785	39	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	DB09061	785	39	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	5284550	41691	15	None	-	9	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1492500	41691	15	None	-	9	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	10184665	3960	51	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	4799	3960	51	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	7353	3960	51	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1198857	3960	51	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	DB09082	3960	51	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	123631	207377	129	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	446	8	1	7	4.3	COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1	10.1038/s41467-023-40064-9
	CHEMBL939	207377	129	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	446	8	1	7	4.3	COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1	10.1038/s41467-023-40064-9
	135398737	955	93	None	-	92	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	955	93	None	-	92	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	955	93	None	-	92	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	955	93	None	-	92	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	955	93	None	-	92	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	5282175	14400	36	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	424	16	2	5	5.1	CCCCCCCC(=O)CC[C@@H]1[C@@H](C/C=C\CCCC(=O)OC(C)C)[C@@H](O)C[C@H]1O	10.1038/s41467-023-40064-9
	CHEMBL1200661	14400	36	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	424	16	2	5	5.1	CCCCCCCC(=O)CC[C@@H]1[C@@H](C/C=C\CCCC(=O)OC(C)C)[C@@H](O)C[C@H]1O	10.1038/s41467-023-40064-9
	11511120	78365	86	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	469	7	2	6	5.2	COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL2110732	78365	86	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	469	7	2	6	5.2	COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN1CCCCC1	10.1038/s41467-023-40064-9
	3191	102831	97	None	-	25	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL305660	102831	97	None	-	25	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
	25077405	2696	0	None	-	1	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	3902	2696	0	None	-	1	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	CHEMBL1201309	2696	0	None	-	1	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	DB00666	2696	0	None	-	1	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	2398	951	62	None	-	29	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2801	951	62	None	-	29	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	701	951	62	None	-	29	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL415	951	62	None	-	29	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB01242	951	62	None	-	29	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	10184653	10965	107	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	8	2	7	4.4	CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1	10.1038/s41467-023-40064-9
	CHEMBL1173655	10965	107	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485	8	2	7	4.4	CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1	10.1038/s41467-023-40064-9
	2585	800	103	None	-	22	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	522	800	103	None	-	22	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	551	800	103	None	-	22	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	CHEMBL723	800	103	None	-	22	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	DB01136	800	103	None	-	22	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	30323	62455	57	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	527	4	5	11	1.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL1563	62455	57	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	527	4	5	11	1.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL178	62455	57	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	527	4	5	11	1.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	2286	3161	51	None	-	30	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927	3161	51	None	-	30	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7282	3161	51	None	-	30	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL643	3161	51	None	-	30	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01069	3161	51	None	-	30	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	6436173	55086	45	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	785	2	5	13	6.2	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
	CHEMBL1617	55086	45	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	785	2	5	13	6.2	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
	2713	205248	82	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5353524	205248	82	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5360566	205248	82	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	88536661	205248	82	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	9552079	205248	82	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1330113	205248	82	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL790	205248	82	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	72093	35031	9	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL1433361	35031	9	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL2103773	35031	9	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL3039583	210926	0	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL		None	None	None		NCCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2C[C@H](OC(=O)NCCN)CN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(OCc3ccccc3)cc2)NC1=O	10.1038/s41467-023-40064-9
	2600	3750	74	None	-	13	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	2608	3750	74	None	-	13	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	5405	3750	74	None	-	13	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL17157	3750	74	None	-	13	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	DB00342	3750	74	None	-	13	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	1209	1645	75	None	-	32	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	203	1645	75	None	-	32	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	3386	1645	75	None	-	32	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL41	1645	75	None	-	32	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00472	1645	75	None	-	32	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	1222	1651	49	None	-	33	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3396	1651	49	None	-	33	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	85	1651	49	None	-	33	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL46516	1651	49	None	-	33	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	DB04842	1651	49	None	-	33	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	2335	11816	22	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11816	22	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11816	22	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11816	22	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	5329102	194703	86	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	CHEMBL535	194703	86	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	68617	205504	62	None	-	26	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1709	205504	62	None	-	26	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL809	205504	62	None	-	26	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	1016	3720	78	None	-56	35	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	2561	3720	78	None	-56	35	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	2733526	3720	78	None	-56	35	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	5384	3720	78	None	-56	35	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL83	3720	78	None	-56	35	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	DB00675	3720	78	None	-56	35	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	4746	204868	31	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1334033	204868	31	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL75880	204868	31	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	118422671	2737	65	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	1887	2737	65	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	71301	2737	65	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	7246	2737	65	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	CHEMBL434394	2737	65	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	DB04861	2737	65	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	16362	3103	71	None	-	30	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2172	3103	71	None	-	30	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	90	3103	71	None	-	30	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1423	3103	71	None	-	30	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01100	3103	71	None	-	30	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	100	3776	58	None	-	56	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2637	3776	58	None	-	56	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	5452	3776	58	None	-	56	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL479	3776	58	None	-	56	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB00679	3776	58	None	-	56	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2274	3151	58	None	-	32	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4917	3151	58	None	-	32	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	7279	3151	58	None	-	32	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL728	3151	58	None	-	32	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00433	3151	58	None	-	32	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	1155	1616	53	None	-	5	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	3343	1616	53	None	-	5	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	557	1616	53	None	-	5	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL32800	1616	53	None	-	5	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	DB01288	1616	53	None	-	5	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	1324	301	25	None	-	4	Mouse	10.1	pEC50	=	10.1	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		None	10.1021/jm049010r
	16154396	301	25	None	-	4	Mouse	10.1	pEC50	=	10.1	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		None	10.1021/jm049010r
	16197727	301	25	None	-	4	Mouse	10.1	pEC50	=	10.1	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		None	10.1021/jm049010r
	44285019	301	25	None	-	4	Mouse	10.1	pEC50	=	10.1	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		None	10.1021/jm049010r
	57514683	301	25	None	-	4	Mouse	10.1	pEC50	=	10.1	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		None	10.1021/jm049010r
	91898441	301	25	None	-	4	Mouse	10.1	pEC50	=	10.1	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		None	10.1021/jm049010r
	CHEMBL441738	301	25	None	-	4	Mouse	10.1	pEC50	=	10.1	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		None	10.1021/jm049010r
	DB04931	301	25	None	-	4	Mouse	10.1	pEC50	=	10.1	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		None	10.1021/jm049010r
	1324	301	25	None	-	4	Mouse	10.0	pEC50	=	10.0	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm020296e
	16154396	301	25	None	-	4	Mouse	10.0	pEC50	=	10.0	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm020296e
	16197727	301	25	None	-	4	Mouse	10.0	pEC50	=	10.0	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm020296e
	44285019	301	25	None	-	4	Mouse	10.0	pEC50	=	10.0	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm020296e
	57514683	301	25	None	-	4	Mouse	10.0	pEC50	=	10.0	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm020296e
	91898441	301	25	None	-	4	Mouse	10.0	pEC50	=	10.0	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm020296e
	CHEMBL441738	301	25	None	-	4	Mouse	10.0	pEC50	=	10.0	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm020296e
	DB04931	301	25	None	-	4	Mouse	10.0	pEC50	=	10.0	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm020296e
	1324	301	25	None	-	4	Mouse	10.0	pEC50	=	10.0	Binding	In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.	ChEMBL		None	None	None		None	10.1021/jm0104872
	16154396	301	25	None	-	4	Mouse	10.0	pEC50	=	10.0	Binding	In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.	ChEMBL		None	None	None		None	10.1021/jm0104872
	16197727	301	25	None	-	4	Mouse	10.0	pEC50	=	10.0	Binding	In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.	ChEMBL		None	None	None		None	10.1021/jm0104872
	44285019	301	25	None	-	4	Mouse	10.0	pEC50	=	10.0	Binding	In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.	ChEMBL		None	None	None		None	10.1021/jm0104872
	57514683	301	25	None	-	4	Mouse	10.0	pEC50	=	10.0	Binding	In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.	ChEMBL		None	None	None		None	10.1021/jm0104872
	91898441	301	25	None	-	4	Mouse	10.0	pEC50	=	10.0	Binding	In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.	ChEMBL		None	None	None		None	10.1021/jm0104872
	CHEMBL441738	301	25	None	-	4	Mouse	10.0	pEC50	=	10.0	Binding	In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.	ChEMBL		None	None	None		None	10.1021/jm0104872
	DB04931	301	25	None	-	4	Mouse	10.0	pEC50	=	10.0	Binding	In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.	ChEMBL		None	None	None		None	10.1021/jm0104872
	1323	2669	55	None	-	3	Mouse	9.9	pEC50	=	9.9	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		None	10.1021/jm049010r
	92432	2669	55	None	-	3	Mouse	9.9	pEC50	=	9.9	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		None	10.1021/jm049010r
	CHEMBL430239	2669	55	None	-	3	Mouse	9.9	pEC50	=	9.9	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		None	10.1021/jm049010r
	1324	301	25	None	-2	4	Human	9.9	pEC50	=	9.9	Binding	Effective concentration required for the biological activity against human Melanocortin 3 receptorEffective concentration required for the biological activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0303103
	16154396	301	25	None	-2	4	Human	9.9	pEC50	=	9.9	Binding	Effective concentration required for the biological activity against human Melanocortin 3 receptorEffective concentration required for the biological activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0303103
	16197727	301	25	None	-2	4	Human	9.9	pEC50	=	9.9	Binding	Effective concentration required for the biological activity against human Melanocortin 3 receptorEffective concentration required for the biological activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0303103
	44285019	301	25	None	-2	4	Human	9.9	pEC50	=	9.9	Binding	Effective concentration required for the biological activity against human Melanocortin 3 receptorEffective concentration required for the biological activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0303103
	57514683	301	25	None	-2	4	Human	9.9	pEC50	=	9.9	Binding	Effective concentration required for the biological activity against human Melanocortin 3 receptorEffective concentration required for the biological activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0303103
	91898441	301	25	None	-2	4	Human	9.9	pEC50	=	9.9	Binding	Effective concentration required for the biological activity against human Melanocortin 3 receptorEffective concentration required for the biological activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0303103
	CHEMBL441738	301	25	None	-2	4	Human	9.9	pEC50	=	9.9	Binding	Effective concentration required for the biological activity against human Melanocortin 3 receptorEffective concentration required for the biological activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0303103
	DB04931	301	25	None	-2	4	Human	9.9	pEC50	=	9.9	Binding	Effective concentration required for the biological activity against human Melanocortin 3 receptorEffective concentration required for the biological activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0303103
	1323	2669	55	None	-	3	Mouse	9.8	pEC50	=	9.8	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm020296e
	92432	2669	55	None	-	3	Mouse	9.8	pEC50	=	9.8	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm020296e
	CHEMBL430239	2669	55	None	-	3	Mouse	9.8	pEC50	=	9.8	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm020296e
	44327392	141838	0	None	-	0	Mouse	9.8	pEC50	=	9.8	Binding	In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.	ChEMBL	1025	21	12	12	-0.6	CCCC[C@H](NC(C)=O)C(=O)N1C(=O)[C@@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]1CC(=O)O	10.1021/jm0104872
	CHEMBL386583	141838	0	None	-	0	Mouse	9.8	pEC50	=	9.8	Binding	In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.	ChEMBL	1025	21	12	12	-0.6	CCCC[C@H](NC(C)=O)C(=O)N1C(=O)[C@@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]1CC(=O)O	10.1021/jm0104872
	1323	2669	55	None	-72	3	Human	9.6	pEC50	=	9.6	Binding	Effective concentration required for the biological activity against human Melanocortin 3 receptorEffective concentration required for the biological activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0303103
	92432	2669	55	None	-72	3	Human	9.6	pEC50	=	9.6	Binding	Effective concentration required for the biological activity against human Melanocortin 3 receptorEffective concentration required for the biological activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0303103
	CHEMBL430239	2669	55	None	-72	3	Human	9.6	pEC50	=	9.6	Binding	Effective concentration required for the biological activity against human Melanocortin 3 receptorEffective concentration required for the biological activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm0303103
	1323	2669	55	None	-	3	Mouse	9.5	pEC50	=	9.5	Binding	Agonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/ml500340z
	92432	2669	55	None	-	3	Mouse	9.5	pEC50	=	9.5	Binding	Agonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/ml500340z
	CHEMBL430239	2669	55	None	-	3	Mouse	9.5	pEC50	=	9.5	Binding	Agonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/ml500340z
	16132144	209256	36	None	-	4	Mouse	9.2	pEC50	=	9.2	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm049010r
	16133793	209256	36	None	-	4	Mouse	9.2	pEC50	=	9.2	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm049010r
	44273719	209256	36	None	-	4	Mouse	9.2	pEC50	=	9.2	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm049010r
	CHEMBL214332	209256	36	None	-	4	Mouse	9.2	pEC50	=	9.2	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm049010r
	16132144	209256	36	None	-30	4	Human	9.2	pEC50	=	9.2	Binding	Effective concentration required for the biological activity against human Melanocortin 3 receptorEffective concentration required for the biological activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0303103
	16133793	209256	36	None	-30	4	Human	9.2	pEC50	=	9.2	Binding	Effective concentration required for the biological activity against human Melanocortin 3 receptorEffective concentration required for the biological activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0303103
	44273719	209256	36	None	-30	4	Human	9.2	pEC50	=	9.2	Binding	Effective concentration required for the biological activity against human Melanocortin 3 receptorEffective concentration required for the biological activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0303103
	CHEMBL214332	209256	36	None	-30	4	Human	9.2	pEC50	=	9.2	Binding	Effective concentration required for the biological activity against human Melanocortin 3 receptorEffective concentration required for the biological activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0303103
	16132144	209256	36	None	-	4	Mouse	9.1	pEC50	=	9.1	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm020296e
	16133793	209256	36	None	-	4	Mouse	9.1	pEC50	=	9.1	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm020296e
	44273719	209256	36	None	-	4	Mouse	9.1	pEC50	=	9.1	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm020296e
	CHEMBL214332	209256	36	None	-	4	Mouse	9.1	pEC50	=	9.1	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm020296e
	16132144	209256	36	None	-	4	Mouse	9.1	pEC50	=	9.1	Binding	In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0104872
	16133793	209256	36	None	-	4	Mouse	9.1	pEC50	=	9.1	Binding	In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0104872
	44273719	209256	36	None	-	4	Mouse	9.1	pEC50	=	9.1	Binding	In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0104872
	CHEMBL214332	209256	36	None	-	4	Mouse	9.1	pEC50	=	9.1	Binding	In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm0104872
	CHEMBL2369959	209717	0	None	-	0	Mouse	9.0	pEC50	=	9.0	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL2370154	209778	0	None	-1	3	Human	8.7	pEC50	=	8.7	Binding	Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsInhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm020021z
	44323211	106991	0	None	-	1	Human	6.0	pEC50	=	6	Binding	Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsInhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	768	7	9	8	-0.1	C[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL315397	106991	0	None	-	1	Human	6.0	pEC50	=	6	Binding	Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsInhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	768	7	9	8	-0.1	C[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL432201	213610	0	None	-	0	Mouse	5.0	pEC50	=	5.0	Binding	In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	CHEMBL96871	215898	0	None	-	0	Mouse	4.9	pEC50	=	4.9	Binding	In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.	ChEMBL		None	None	None		CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	CHEMBL327479	211271	0	None	-	0	Mouse	4.9	pEC50	=	4.9	Binding	In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	44323233	106689	0	None	-4	2	Human	7.9	pEC50	=	7.9	Binding	Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsInhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	901	11	12	9	0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)c2ccccc2C(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL314401	106689	0	None	-4	2	Human	7.9	pEC50	=	7.9	Binding	Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsInhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	901	11	12	9	0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)c2ccccc2C(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL2369972	209730	0	None	-	0	Mouse	4.9	pEC50	=	4.9	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL347364	211690	0	None	-	0	Mouse	4.9	pEC50	=	4.9	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/jm020296e
	CHEMBL2369970	209728	0	None	-	0	Mouse	4.9	pEC50	=	4.9	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL2369983	209741	0	None	-	0	Mouse	7.9	pEC50	=	7.9	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL94369	215885	0	None	-	0	Mouse	4.8	pEC50	=	4.8	Binding	In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	CHEMBL154251	208778	0	None	-	0	Mouse	4.8	pEC50	=	4.8	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/jm020296e
	CHEMBL320157	211203	0	None	-	0	Mouse	4.8	pEC50	=	4.8	Binding	In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.	ChEMBL		None	None	None		CC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	44369234	45216	0	None	-	0	Mouse	6.8	pEC50	=	6.8	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL	685	18	9	7	-0.6	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC(Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm020296e
	CHEMBL152612	45216	0	None	-	0	Mouse	6.8	pEC50	=	6.8	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL	685	18	9	7	-0.6	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC(Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm020296e
	CHEMBL264190	210585	1	None	-39	2	Mouse	6.8	pEC50	=	6.8	Binding	In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	CHEMBL188738	209036	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O)C(C)=O	10.1021/jm0490033
	CHEMBL190551	209043	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O	10.1021/jm0490033
	CHEMBL358833	211780	0	None	-	0	Mouse	4.8	pEC50	=	4.8	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(N)=O)C(c1ccccc1)c1ccccc1	10.1021/jm020296e
	CHEMBL347216	211689	0	None	-	0	Mouse	5.8	pEC50	=	5.8	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/jm020296e
	CHEMBL348901	211693	0	None	-	0	Mouse	4.8	pEC50	=	4.8	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(N)=O	10.1021/jm020296e
	11038873	171856	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	In vitro effective concentration towards human Melanocortin 3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin 3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cells	ChEMBL	545	12	3	6	2.9	CCCC(=O)C1(c2ccccc2)CCN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@H](N)Cc2c[nH]cn2)CC1	10.1021/jm025600i
	CHEMBL446941	171856	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	In vitro effective concentration towards human Melanocortin 3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin 3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cells	ChEMBL	545	12	3	6	2.9	CCCC(=O)C1(c2ccccc2)CCN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@H](N)Cc2c[nH]cn2)CC1	10.1021/jm025600i
	CHEMBL2369976	209734	0	None	-	0	Mouse	4.8	pEC50	=	4.8	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	44323020	168972	0	None	7	3	Human	7.8	pEC50	=	7.8	Binding	Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsInhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	951	11	12	9	1.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)c2ccccc2C(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL439188	168972	0	None	7	3	Human	7.8	pEC50	=	7.8	Binding	Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsInhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	951	11	12	9	1.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)c2ccccc2C(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL431092	213599	0	None	-	0	Mouse	4.7	pEC50	=	4.7	Binding	In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	CHEMBL188459	209034	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N(CCCCN)CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O)C(C)=O	10.1021/jm0490033
	CHEMBL372237	212149	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O	10.1021/jm0490033
	CHEMBL346925	211688	0	None	-	0	Mouse	4.7	pEC50	=	4.7	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O	10.1021/jm020296e
	44269189	98310	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	In vitro effective concentration towards human Melanocortin 3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin 3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cells	ChEMBL	587	13	3	6	3.1	CCCC(=O)C1(c2ccccc2)CCN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(C)=O)CC1	10.1021/jm025600i
	CHEMBL275067	98310	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	In vitro effective concentration towards human Melanocortin 3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin 3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cells	ChEMBL	587	13	3	6	3.1	CCCC(=O)C1(c2ccccc2)CCN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(C)=O)CC1	10.1021/jm025600i
	CHEMBL317968	211184	0	None	-	0	Mouse	5.6	pEC50	=	5.6	Binding	In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	CHEMBL2096693	209181	0	None	-	0	Mouse	4.6	pEC50	=	4.6	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/jm020296e
	CHEMBL2369969	209727	0	None	-	0	Mouse	4.6	pEC50	=	4.6	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL373344	212152	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O)C(C)=O	10.1021/jm0490033
	44269217	30229	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	In vitro effective concentration towards human Melanocortin 3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin 3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cells	ChEMBL	649	14	3	6	4.4	CCCC(=O)C1(c2ccccc2)CCN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)c2ccccc2)CC1	10.1021/jm025600i
	CHEMBL13910	30229	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	In vitro effective concentration towards human Melanocortin 3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin 3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cells	ChEMBL	649	14	3	6	4.4	CCCC(=O)C1(c2ccccc2)CCN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)c2ccccc2)CC1	10.1021/jm025600i
	CHEMBL152986	208774	0	None	-	0	Mouse	4.6	pEC50	=	4.6	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/jm020296e
	CHEMBL2369967	209725	0	None	-	0	Mouse	7.5	pEC50	=	7.5	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL330561	211310	0	None	-	0	Mouse	5.5	pEC50	=	5.5	Binding	In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	1325	3573	14	None	-12	7	Mouse	8.5	pEC50	=	8.5	Binding	Agonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/ml500340z
	6440621	3573	14	None	-12	7	Mouse	8.5	pEC50	=	8.5	Binding	Agonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/ml500340z
	9898183	3573	14	None	-12	7	Mouse	8.5	pEC50	=	8.5	Binding	Agonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/ml500340z
	CHEMBL3422426	3573	14	None	-12	7	Mouse	8.5	pEC50	=	8.5	Binding	Agonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		None	10.1021/ml500340z
	CHEMBL349795	211697	0	None	-	0	Mouse	4.5	pEC50	=	4.5	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1cccs1)C(N)=O	10.1021/jm020296e
	CHEMBL2369977	209735	0	None	-	0	Mouse	4.5	pEC50	=	4.5	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL186970	209031	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N(CCCCN)CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1021/jm0490033
	CHEMBL191120	209057	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N(CC(=O)NCC(N)=O)Cc1c[nH]c2ccccc12	10.1021/jm0490033
	CHEMBL365262	212014	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O)C(C)=O	10.1021/jm0490033
	CHEMBL2369982	209740	0	None	-	0	Mouse	6.5	pEC50	=	6.5	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL2369975	209733	0	None	-	0	Mouse	7.5	pEC50	=	7.5	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL2371147	209994	0	None	-	0	Mouse	4.5	pEC50	=	4.5	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@]1(C(N)=O)CCc2ccccc2C1	10.1021/jm020296e
	CHEMBL2369966	209724	0	None	-	0	Mouse	5.5	pEC50	=	5.5	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL154153	208777	0	None	-	0	Mouse	5.5	pEC50	=	5.5	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1cccc2ccccc12)C(N)=O	10.1021/jm020296e
	CHEMBL151906	208771	0	None	-	0	Mouse	5.4	pEC50	=	5.4	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1csc2ccccc12)C(N)=O	10.1021/jm020296e
	44269214	98466	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	In vitro effective concentration towards human Melanocortin-3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin-3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cells	ChEMBL	546	12	3	6	3.0	CCCC(=O)C1(c2ccccc2)CCN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@H](O)Cc2c[nH]cn2)CC1	10.1021/jm025600i
	CHEMBL276012	98466	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	In vitro effective concentration towards human Melanocortin-3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin-3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cells	ChEMBL	546	12	3	6	3.0	CCCC(=O)C1(c2ccccc2)CCN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@H](O)Cc2c[nH]cn2)CC1	10.1021/jm025600i
	CHEMBL2369962	209720	0	None	-	0	Mouse	4.4	pEC50	=	4.4	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL365794	212018	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N(CCCCN)CC(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O	10.1021/jm0490033
	CHEMBL370321	212144	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1021/jm0490033
	44323212	168695	0	None	1	2	Human	4.4	pEC50	=	4.4	Binding	Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsInhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	787	9	10	8	-1.0	C[C@@H]1NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC1=O	10.1021/jm020021z
	CHEMBL436903	168695	0	None	1	2	Human	4.4	pEC50	=	4.4	Binding	Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsInhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	787	9	10	8	-1.0	C[C@@H]1NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC1=O	10.1021/jm020021z
	CHEMBL2369965	209723	0	None	-	0	Mouse	6.4	pEC50	=	6.4	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	137635396	155826	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity at mouse MC3RAgonist activity at mouse MC3R	ChEMBL	1607	50	22	21	-4.6	CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acs.jmedchem.7b00301
	CHEMBL4060118	155826	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity at mouse MC3RAgonist activity at mouse MC3R	ChEMBL	1607	50	22	21	-4.6	CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/acs.jmedchem.7b00301
	CHEMBL2369963	209721	0	None	-	0	Mouse	8.3	pEC50	=	8.3	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL190080	209039	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCCN=C(N)N)CC(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O	10.1021/jm0490033
	CHEMBL190953	209054	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N(CCCCN)CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N(CC(=O)NCC(N)=O)Cc1c[nH]c2ccccc12	10.1021/jm0490033
	CHEMBL2371829	210111	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O)C(C)=O	10.1021/jm0490033
	CHEMBL152555	208772	0	None	-	0	Mouse	4.3	pEC50	=	4.3	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(N)=O)C(c1ccccc1)c1ccccc1	10.1021/jm020296e
	CHEMBL264190	210585	1	None	-39	2	Mouse	5.3	pEC50	=	5.3	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm020296e
	CHEMBL2304247	209461	0	None	-	0	Mouse	8.2	pEC50	=	8.2	Binding	Displacement of MT2 from mouse MC3R expressed in HEK293 cellsDisplacement of MT2 from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)O	10.1021/jm0492756
	CHEMBL3350327	211447	0	None	-	0	Mouse	8.2	pEC50	=	8.2	Binding	Displacement of MT2 from mouse MC3R expressed in HEK293 cellsDisplacement of MT2 from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)O	10.1021/jm0492756
	CHEMBL2369964	209722	0	None	-	0	Mouse	8.2	pEC50	=	8.2	Binding	Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)[C@@](C)(C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049010r
	CHEMBL94391	215886	0	None	-	0	Mouse	5.2	pEC50	=	5.2	Binding	In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.	ChEMBL		None	None	None		CC(=O)N[C@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	CHEMBL191063	209056	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N(CC(=O)NCC(N)=O)Cc1c[nH]c2ccccc12	10.1021/jm0490033
	CHEMBL189991	209038	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N(CCCCN)CC(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N(CC(=O)NCC(N)=O)Cc1c[nH]c2ccccc12	10.1021/jm0490033
	CHEMBL190732	209044	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N(CCCCN)CC(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O)C(C)=O	10.1021/jm0490033
	CHEMBL264190	210585	1	None	-39	2	Mouse	7.2	pEC50	=	7.2	Binding	Agonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/ml500340z
	10260053	168179	0	None	4	3	Human	7.2	pEC50	=	7.2	Binding	Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsInhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	871	27	12	10	-1.1	NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm020021z
	CHEMBL433413	168179	0	None	4	3	Human	7.2	pEC50	=	7.2	Binding	Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsInhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	871	27	12	10	-1.1	NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm020021z
	CHEMBL365913	212020	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1021/jm0490033
	44323234	168032	0	None	7	3	Human	7.2	pEC50	=	7.2	Binding	Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsInhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	903	11	12	9	0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL432377	168032	0	None	7	3	Human	7.2	pEC50	=	7.2	Binding	Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsInhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	903	11	12	9	0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	44322795	206903	0	None	-13	3	Human	7.2	pEC50	=	7.2	Binding	Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsInhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	853	11	12	9	-0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL91041	206903	0	None	-13	3	Human	7.2	pEC50	=	7.2	Binding	Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsInhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	853	11	12	9	-0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	11813437	98501	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	In vitro effective concentration towards human Melanocortin 3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin 3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cells	ChEMBL	530	12	2	5	4.0	CCCC(=O)C1(c2ccccc2)CCN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)CCc2c[nH]cn2)CC1	10.1021/jm025600i
	CHEMBL276301	98501	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	In vitro effective concentration towards human Melanocortin 3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin 3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cells	ChEMBL	530	12	2	5	4.0	CCCC(=O)C1(c2ccccc2)CCN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)CCc2c[nH]cn2)CC1	10.1021/jm025600i
	CHEMBL357558	211720	0	None	-	0	Mouse	6.1	pEC50	=	6.1	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/jm020296e
	44322869	106133	0	None	6	3	Human	7.1	pEC50	=	7.1	Binding	Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsInhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	867	11	12	9	-0.4	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL313690	106133	0	None	6	3	Human	7.1	pEC50	=	7.1	Binding	Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsInhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	867	11	12	9	-0.4	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	46877881	201795	0	None	-2	3	Human	6.1	pEC50	=	6.1	Binding	Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsInhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	813	9	10	8	-0.3	N=C(N)NCCC[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL606990	201795	0	None	-2	3	Human	6.1	pEC50	=	6.1	Binding	Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsInhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	813	9	10	8	-0.3	N=C(N)NCCC[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL190203	209041	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N(CC(=O)NCC(N)=O)Cc1c[nH]c2ccccc12)C(C)=O	10.1021/jm0490033
	CHEMBL330233	211308	0	None	-	0	Mouse	5.1	pEC50	=	5.1	Binding	In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.	ChEMBL		None	None	None		CC(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm0104872
	CHEMBL2371147	209994	0	None	-	0	Mouse	5.0	pEC50	=	5	Binding	Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@]1(C(N)=O)CCc2ccccc2C1	10.1021/jm020296e
	CHEMBL1161322	208485	0	None	-1	2	Human	9.7	pIC50	=	9.7	Binding	Binding affinity for human Melanocortin-3 receptorBinding affinity for human Melanocortin-3 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2CCCN2C1=O	10.1021/jm0202526
	44366081	10230	0	None	-2	2	Human	9.7	pIC50	=	9.7	Binding	Binding affinity for human Melanocortin-3 receptorBinding affinity for human Melanocortin-3 receptor	ChEMBL	1036	15	13	11	0.4	CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(O)[C@H]2CCCN2C1=O	10.1021/jm0202526
	CHEMBL1161313	10230	0	None	-2	2	Human	9.7	pIC50	=	9.7	Binding	Binding affinity for human Melanocortin-3 receptorBinding affinity for human Melanocortin-3 receptor	ChEMBL	1036	15	13	11	0.4	CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(O)[C@H]2CCCN2C1=O	10.1021/jm0202526
	CHEMBL2096742	209183	0	None	-5	2	Human	9.6	pIC50	=	9.6	Binding	Binding affinity for human Melanocortin-3 receptorBinding affinity for human Melanocortin-3 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm0202526
	CHEMBL500743	214101	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](NC(=N)N)CN2C1=O	10.1021/jm801300c
	1324	301	25	None	-2	4	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]NDP-MSH from Melanocortin 3 receptor at 10 uMDisplacement of [125I]NDP-MSH from Melanocortin 3 receptor at 10 uM	ChEMBL		None	None	None		None	10.1021/jm960840h
	16154396	301	25	None	-2	4	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]NDP-MSH from Melanocortin 3 receptor at 10 uMDisplacement of [125I]NDP-MSH from Melanocortin 3 receptor at 10 uM	ChEMBL		None	None	None		None	10.1021/jm960840h
	16197727	301	25	None	-2	4	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]NDP-MSH from Melanocortin 3 receptor at 10 uMDisplacement of [125I]NDP-MSH from Melanocortin 3 receptor at 10 uM	ChEMBL		None	None	None		None	10.1021/jm960840h
	44285019	301	25	None	-2	4	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]NDP-MSH from Melanocortin 3 receptor at 10 uMDisplacement of [125I]NDP-MSH from Melanocortin 3 receptor at 10 uM	ChEMBL		None	None	None		None	10.1021/jm960840h
	57514683	301	25	None	-2	4	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]NDP-MSH from Melanocortin 3 receptor at 10 uMDisplacement of [125I]NDP-MSH from Melanocortin 3 receptor at 10 uM	ChEMBL		None	None	None		None	10.1021/jm960840h
	91898441	301	25	None	-2	4	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]NDP-MSH from Melanocortin 3 receptor at 10 uMDisplacement of [125I]NDP-MSH from Melanocortin 3 receptor at 10 uM	ChEMBL		None	None	None		None	10.1021/jm960840h
	CHEMBL441738	301	25	None	-2	4	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]NDP-MSH from Melanocortin 3 receptor at 10 uMDisplacement of [125I]NDP-MSH from Melanocortin 3 receptor at 10 uM	ChEMBL		None	None	None		None	10.1021/jm960840h
	DB04931	301	25	None	-2	4	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]NDP-MSH from Melanocortin 3 receptor at 10 uMDisplacement of [125I]NDP-MSH from Melanocortin 3 receptor at 10 uM	ChEMBL		None	None	None		None	10.1021/jm960840h
	1324	301	25	None	-2	4	Human	8.9	pIC50	=	8.9	Binding	Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		None	10.1021/jm960845e
	16154396	301	25	None	-2	4	Human	8.9	pIC50	=	8.9	Binding	Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		None	10.1021/jm960845e
	16197727	301	25	None	-2	4	Human	8.9	pIC50	=	8.9	Binding	Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		None	10.1021/jm960845e
	44285019	301	25	None	-2	4	Human	8.9	pIC50	=	8.9	Binding	Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		None	10.1021/jm960845e
	57514683	301	25	None	-2	4	Human	8.9	pIC50	=	8.9	Binding	Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		None	10.1021/jm960845e
	91898441	301	25	None	-2	4	Human	8.9	pIC50	=	8.9	Binding	Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		None	10.1021/jm960845e
	CHEMBL441738	301	25	None	-2	4	Human	8.9	pIC50	=	8.9	Binding	Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		None	10.1021/jm960845e
	DB04931	301	25	None	-2	4	Human	8.9	pIC50	=	8.9	Binding	Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		None	10.1021/jm960845e
	1323	2669	55	None	-72	3	Human	8.9	pIC50	=	8.9	Binding	Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysisDisplacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysis	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01285
	92432	2669	55	None	-72	3	Human	8.9	pIC50	=	8.9	Binding	Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysisDisplacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysis	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01285
	CHEMBL430239	2669	55	None	-72	3	Human	8.9	pIC50	=	8.9	Binding	Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysisDisplacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysis	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01285
	1323	2669	55	None	-72	3	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00488
	92432	2669	55	None	-72	3	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00488
	CHEMBL430239	2669	55	None	-72	3	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00488
	145972289	164496	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	915	11	12	9	0.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4214826	164496	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	915	11	12	9	0.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	44418421	168569	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	387	5	1	2	4.0	O=C(CCc1c[nH]c2ccccc12)N1C[C@@H]2CCCN2C[C@H]1Cc1ccccc1	10.1016/j.bmcl.2006.07.015
	CHEMBL435923	168569	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	387	5	1	2	4.0	O=C(CCc1c[nH]c2ccccc12)N1C[C@@H]2CCCN2C[C@H]1Cc1ccccc1	10.1016/j.bmcl.2006.07.015
	CHEMBL393075	212439	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]NDPalphaMSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDPalphaMSH from human MC3R expressed in HEK293 cells	ChEMBL		None	None	None		CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1016/j.bmcl.2007.02.020
	1323	2669	55	None	-72	3	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm070461w
	92432	2669	55	None	-72	3	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm070461w
	CHEMBL430239	2669	55	None	-72	3	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm070461w
	1323	2669	55	None	-72	3	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm801300c
	92432	2669	55	None	-72	3	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm801300c
	CHEMBL430239	2669	55	None	-72	3	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm801300c
	1323	2669	55	None	-72	3	Human	8.9	pIC50	=	8.9	Binding	Inhibitory activity against hMC3R transfected in HEK293 cellsInhibitory activity against hMC3R transfected in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm0510326
	92432	2669	55	None	-72	3	Human	8.9	pIC50	=	8.9	Binding	Inhibitory activity against hMC3R transfected in HEK293 cellsInhibitory activity against hMC3R transfected in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm0510326
	CHEMBL430239	2669	55	None	-72	3	Human	8.9	pIC50	=	8.9	Binding	Inhibitory activity against hMC3R transfected in HEK293 cellsInhibitory activity against hMC3R transfected in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm0510326
	CHEMBL204310	209141	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Inhibitory activity against hMC3R transfected in HEK293 cellsInhibitory activity against hMC3R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCC(N)=O)NC1=O	10.1021/jm0510326
	122184576	122402	0	None	-	1	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600837	122402	0	None	-	1	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL413573	213052	0	None	-1	2	Human	8.8	pIC50	=	8.8	Binding	Inhibitory activity against hMC3R transfected in HEK293 cellsInhibitory activity against hMC3R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](C(C)C)NC1=O	10.1021/jm0510326
	CHEMBL428801	213449	0	None	-100	3	Human	8.7	pIC50	=	8.7	Binding	Inhibitory activity against human Melanocortin 3 receptorInhibitory activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(I)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm00018a005
	1323	2669	55	None	-72	3	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1016/j.bmcl.2006.07.015
	92432	2669	55	None	-72	3	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1016/j.bmcl.2006.07.015
	CHEMBL430239	2669	55	None	-72	3	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1016/j.bmcl.2006.07.015
	133053557	163682	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	851	11	12	9	-1.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4204975	163682	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	851	11	12	9	-1.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	118735101	118775	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells by gamma counting analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells by gamma counting analysis	ChEMBL	824	15	9	6	2.4	CC(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN([C@H](Cc2ccc(Br)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	CHEMBL3421678	118775	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells by gamma counting analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells by gamma counting analysis	ChEMBL	824	15	9	6	2.4	CC(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN([C@H](Cc2ccc(Br)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	CHEMBL410795	212819	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Binding affinity for Human Melanocortin 3 receptor expressed in L-cellsBinding affinity for Human Melanocortin 3 receptor expressed in L-cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	118735103	118777	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells by gamma counting analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells by gamma counting analysis	ChEMBL	698	15	8	9	-0.8	CC(=O)N[C@H]1Cn2nncc2CN([C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	CHEMBL3421680	118777	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells by gamma counting analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells by gamma counting analysis	ChEMBL	698	15	8	9	-0.8	CC(=O)N[C@H]1Cn2nncc2CN([C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	44315095	103106	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Binding affinity towards human melanocortin 3 receptor (hMC3R) using [125I]NDP-alpha-MSH as radioligandBinding affinity towards human melanocortin 3 receptor (hMC3R) using [125I]NDP-alpha-MSH as radioligand	ChEMBL	559	13	3	4	4.2	CC(=O)N[C@@H](Cc1ccccc1)C(=O)N(CCCCN)C1CCC(N(CCc2c[nH]c3ccccc23)C(C)=O)CC1	10.1016/s0960-894x(03)00412-8
	CHEMBL307857	103106	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Binding affinity towards human melanocortin 3 receptor (hMC3R) using [125I]NDP-alpha-MSH as radioligandBinding affinity towards human melanocortin 3 receptor (hMC3R) using [125I]NDP-alpha-MSH as radioligand	ChEMBL	559	13	3	4	4.2	CC(=O)N[C@@H](Cc1ccccc1)C(=O)N(CCCCN)C1CCC(N(CCc2c[nH]c3ccccc23)C(C)=O)CC1	10.1016/s0960-894x(03)00412-8
	155544852	174915	0	None	-31	4	Mouse	5.0	pIC50	=	5	Binding	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL	977	12	10	10	-0.5	CC(C)[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	CHEMBL4565367	174915	0	None	-31	4	Mouse	5.0	pIC50	=	5	Binding	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL	977	12	10	10	-0.5	CC(C)[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	CHEMBL410217	212785	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		CC(=O)N[C@@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC1=O	10.1021/jm960845e
	127047853	139968	0	None	-	0	Mouse	5.0	pIC50	=	5.0	Binding	Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisDisplacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	ChEMBL	1948	72	23	25	-2.1	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL3799955	139968	0	None	-	0	Mouse	5.0	pIC50	=	5.0	Binding	Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisDisplacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	ChEMBL	1948	72	23	25	-2.1	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	44448629	167439	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	619	6	1	3	7.0	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Br)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL429854	167439	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	619	6	1	3	7.0	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Br)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	122184635	122408	0	None	1	4	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600916	122408	0	None	1	4	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	145977650	163810	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	865	11	12	9	-0.7	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4206406	163810	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	865	11	12	9	-0.7	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	44445083	154281	0	None	-	1	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	953	9	10	9	2.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)c2ccccc2C(=O)CCCNCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL398665	154281	0	None	-	1	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	953	9	10	9	2.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)c2ccccc2C(=O)CCCNCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	145948876	167459	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysisDisplacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysis	ChEMBL	1220	17	14	11	1.9	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2CCCN2C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.5b01285
	CHEMBL4299441	167459	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysisDisplacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysis	ChEMBL	1220	17	14	11	1.9	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2CCCN2C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.5b01285
	CHEMBL1161316	208481	0	None	-63	2	Human	7.0	pIC50	=	7.0	Binding	Binding affinity for human Melanocortin-3 receptorBinding affinity for human Melanocortin-3 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(CCCC2)NC1=O	10.1021/jm0202526
	6918813	131345	3	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Concentration for 50% inhibition of human melanocortin-3 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligandConcentration for 50% inhibition of human melanocortin-3 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligand	ChEMBL	557	7	3	5	2.9	CN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	CHEMBL368876	131345	3	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Concentration for 50% inhibition of human melanocortin-3 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligandConcentration for 50% inhibition of human melanocortin-3 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligand	ChEMBL	557	7	3	5	2.9	CN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	24774602	168907	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	766	9	10	9	-0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)c2nccnc2C(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL438744	168907	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	766	9	10	9	-0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)c2nccnc2C(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL2096710	209182	0	None	-	1	Mouse	4.9	pIC50	=	4.9	Binding	Displacement of [125I]-hAGRP(87-132) from mouse Melanocortin 3 ReceptorDisplacement of [125I]-hAGRP(87-132) from mouse Melanocortin 3 Receptor	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/jm049620r
	44445085	97045	0	None	-2	2	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	879	9	11	9	1.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](N)CCCCC(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL267265	97045	0	None	-2	2	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	879	9	11	9	1.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](N)CCCCC(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL425591	213315	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity against hMC3R transfected in HEK293 cellsInhibitory activity against hMC3R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm0510326
	10304547	168228	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cells	ChEMBL	620	7	3	4	5.7	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2CCc3ccccc3[C@H]2N)CC1	10.1016/j.bmcl.2005.05.012
	CHEMBL433764	168228	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cells	ChEMBL	620	7	3	4	5.7	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2CCc3ccccc3[C@H]2N)CC1	10.1016/j.bmcl.2005.05.012
	CHEMBL382369	212282	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibitory activity against hMC3R transfected in HEK293 cellsInhibitory activity against hMC3R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm0510326
	44448479	155347	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	573	6	1	3	7.3	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL403420	155347	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	573	6	1	3	7.3	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2008.04.049
	176	397	66	None	-6	31	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2157	397	66	None	-6	31	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2566	397	66	None	-6	31	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	CHEMBL633	397	66	None	-6	31	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	DB01118	397	66	None	-6	31	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	CHEMBL373344	212152	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O)C(C)=O	10.1021/jm0490033
	CHEMBL188459	209034	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N(CCCCN)CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O)C(C)=O	10.1021/jm0490033
	CHEMBL190203	209041	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N(CC(=O)NCC(N)=O)Cc1c[nH]c2ccccc12)C(C)=O	10.1021/jm0490033
	CHEMBL3578004	211735	0	None	-	0	Mouse	6.9	pIC50	=	6.9	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@H]1CSSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O	10.1021/acs.jmedchem.5b00184
	122184909	122528	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3601427	122528	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL203760	209138	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity against hMC3R transfected in HEK293 cellsInhibitory activity against hMC3R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/jm0510326
	122184638	122411	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600919	122411	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	71449047	78451	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL	1533	33	16	22	-1.3	CC(=O)[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	CHEMBL2111807	78451	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL	1533	33	16	22	-1.3	CC(=O)[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	127047624	139871	0	None	-177	3	Mouse	5.9	pIC50	=	5.9	Binding	Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisDisplacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	ChEMBL	1054	36	12	13	-0.1	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL3799408	139871	0	None	-177	3	Mouse	5.9	pIC50	=	5.9	Binding	Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisDisplacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	ChEMBL	1054	36	12	13	-0.1	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(N)=O	10.1021/acs.jmedchem.5b01894
	127046235	139613	0	None	-	0	Mouse	4.9	pIC50	=	4.9	Binding	Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisDisplacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	ChEMBL	1004	36	12	13	-1.3	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL3797690	139613	0	None	-	0	Mouse	4.9	pIC50	=	4.9	Binding	Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisDisplacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	ChEMBL	1004	36	12	13	-1.3	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(N)=O	10.1021/acs.jmedchem.5b01894
	10188529	126755	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	582	7	2	4	4.7	CN1C[C@H]2CC[C@@H]1[C@@H](C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC1)C2	10.1016/j.bmcl.2005.05.109
	CHEMBL365401	126755	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	582	7	2	4	4.7	CN1C[C@H]2CC[C@@H]1[C@@H](C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC1)C2	10.1016/j.bmcl.2005.05.109
	CHEMBL3350396	211456	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm960845e
	145964837	164323	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	875	11	12	9	-0.5	CC1(C)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4212629	164323	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	875	11	12	9	-0.5	CC1(C)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL2373991	210358	0	None	-5	2	Mouse	6.9	pIC50	=	6.9	Binding	Displacement of [125I]-hAGRP(87-132) from mouse Melanocortin 3 ReceptorDisplacement of [125I]-hAGRP(87-132) from mouse Melanocortin 3 Receptor	ChEMBL		None	None	None		CC[C@@H]1NC(=O)[C@H](N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CSSC[C@H](NC(=O)[C@@H](Cc3ccc(O)cc3)NC(=O)[C@H](CC)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](C)NC(=O)[C@H](CC)NC(=O)[C@@H]3CCCN3C(=O)[C@@H](CC(=O)O)NC1=O)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2	10.1021/jm049620r
	CHEMBL263822	210567	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against hMC3R transfected in HEK293 cellsInhibitory activity against hMC3R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCCN=C(N)N)NC1=O	10.1021/jm0510326
	CHEMBL383250	212289	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against hMC3R transfected in HEK293 cellsInhibitory activity against hMC3R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCC(=O)O)NC1=O	10.1021/jm0510326
	CHEMBL2371962	210136	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]NDPalphaMSH from human cloned MC3R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC3R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2C(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm0614275
	CHEMBL103817	208436	0	None	-52	3	Mouse	5.8	pIC50	=	5.8	Binding	Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisDisplacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	122184634	122407	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600915	122407	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	44448660	94944	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	575	6	1	3	6.9	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Cl)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL254589	94944	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	575	6	1	3	6.9	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(Cl)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	44449216	95242	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	559	6	1	3	6.4	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(F)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL256286	95242	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	559	6	1	3	6.4	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(F)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL3600912	211798	0	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	44366171	121268	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity for human Melanocortin-3 receptorBinding affinity for human Melanocortin-3 receptor	ChEMBL	766	9	10	7	0.9	N=C(N)NCCC[C@H]1NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm0202526
	CHEMBL358015	121268	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity for human Melanocortin-3 receptorBinding affinity for human Melanocortin-3 receptor	ChEMBL	766	9	10	7	0.9	N=C(N)NCCC[C@H]1NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm0202526
	127053936	152216	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Radioligand Binding Assay: Radioligand binding assays were carried out using commercial or in-house prepared hMC1R, hMC3R and hMC4R membranes and [125I] NDP-MSH, as per the hMC5R procedure in Example 102. In-house plasma membranes were prepared from transfected mammalian cells (prepared as in Example 109, using plasmid DNA containing the human MC1R, MC3R or MC4R gene or other gene of interest in a plasmid vector with a mammalian origin of replication): Adherent cells were washed with warm Hanks buffered saline solution (HBSS). 1 mL of cold HBSS was added to each flask and the cells were scraped off with a rubber policeman. The scraped cells were added to a 50 mL tube on ice. The plates were then rinsed twice with 5 mL cold HBSS and this was also added to the tube. The cells were centrifuged at 1000×g for 5 mins in a bench top centrifuge and the supernatant was decanted. The remaining cell pellet was resuspended in 0.25 M sucrose. The cell suspension was centrifuged again as previously and the pellet resuspended in 5 mL of 0.25 M sucrose containing protease inhibitors. The cells were homogenised by a 10 second pulse with an Ika disperser followed by 30 seconds on ice. The homogenisation and ice incubation was repeated three times. The mixture was then centrifuged at 1260×g for 5 mins. The supernatant was decanted into another centrifuge tube, to which a buffer containing 50 mM Tris, pH 7.4, 12.5 mM MgCl2, 5 mM EGTA and protease inhibitors was added to make the volume up to 30 mL. This was centrifuged at 30,000×g for 90 mins at 4° C. The resulting pellet was resuspended in 1 mL of the buffer above also containing 10% glycerol. Membranes were aliquoted into cryovials which were snap-frozen in a dry-ice/ethanol bath before being stored at −80° C. until required for use.Radioligand Binding Assay: Radioligand binding assays were carried out using commercial or in-house prepared hMC1R, hMC3R and hMC4R membranes and [125I] NDP-MSH, as per the hMC5R procedure in Example 102. In-house plasma membranes were prepared from transfected mammalian cells (prepared as in Example 109, using plasmid DNA containing the human MC1R, MC3R or MC4R gene or other gene of interest in a plasmid vector with a mammalian origin of replication): Adherent cells were washed with warm Hanks buffered saline solution (HBSS). 1 mL of cold HBSS was added to each flask and the cells were scraped off with a rubber policeman. The scraped cells were added to a 50 mL tube on ice. The plates were then rinsed twice with 5 mL cold HBSS and this was also added to the tube. The cells were centrifuged at 1000×g for 5 mins in a bench top centrifuge and the supernatant was decanted. The remaining cell pellet was resuspended in 0.25 M sucrose. The cell suspension was centrifuged again as previously and the pellet resuspended in 5 mL of 0.25 M sucrose containing protease inhibitors. The cells were homogenised by a 10 second pulse with an Ika disperser followed by 30 seconds on ice. The homogenisation and ice incubation was repeated three times. The mixture was then centrifuged at 1260×g for 5 mins. The supernatant was decanted into another centrifuge tube, to which a buffer containing 50 mM Tris, pH 7.4, 12.5 mM MgCl2, 5 mM EGTA and protease inhibitors was added to make the volume up to 30 mL. This was centrifuged at 30,000×g for 90 mins at 4° C. The resulting pellet was resuspended in 1 mL of the buffer above also containing 10% glycerol. Membranes were aliquoted into cryovials which were snap-frozen in a dry-ice/ethanol bath before being stored at −80° C. until required for use.	ChEMBL	598	11	2	4	5.7	O=C(/C=C/c1ccc(Cl)cc1)NC[C@H]1CCN(CC(c2ccccc2)c2ccccc2)C(=O)[C@@H](CCN2CCCCC2)N1	nan
	CHEMBL3968918	152216	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Radioligand Binding Assay: Radioligand binding assays were carried out using commercial or in-house prepared hMC1R, hMC3R and hMC4R membranes and [125I] NDP-MSH, as per the hMC5R procedure in Example 102. In-house plasma membranes were prepared from transfected mammalian cells (prepared as in Example 109, using plasmid DNA containing the human MC1R, MC3R or MC4R gene or other gene of interest in a plasmid vector with a mammalian origin of replication): Adherent cells were washed with warm Hanks buffered saline solution (HBSS). 1 mL of cold HBSS was added to each flask and the cells were scraped off with a rubber policeman. The scraped cells were added to a 50 mL tube on ice. The plates were then rinsed twice with 5 mL cold HBSS and this was also added to the tube. The cells were centrifuged at 1000×g for 5 mins in a bench top centrifuge and the supernatant was decanted. The remaining cell pellet was resuspended in 0.25 M sucrose. The cell suspension was centrifuged again as previously and the pellet resuspended in 5 mL of 0.25 M sucrose containing protease inhibitors. The cells were homogenised by a 10 second pulse with an Ika disperser followed by 30 seconds on ice. The homogenisation and ice incubation was repeated three times. The mixture was then centrifuged at 1260×g for 5 mins. The supernatant was decanted into another centrifuge tube, to which a buffer containing 50 mM Tris, pH 7.4, 12.5 mM MgCl2, 5 mM EGTA and protease inhibitors was added to make the volume up to 30 mL. This was centrifuged at 30,000×g for 90 mins at 4° C. The resulting pellet was resuspended in 1 mL of the buffer above also containing 10% glycerol. Membranes were aliquoted into cryovials which were snap-frozen in a dry-ice/ethanol bath before being stored at −80° C. until required for use.Radioligand Binding Assay: Radioligand binding assays were carried out using commercial or in-house prepared hMC1R, hMC3R and hMC4R membranes and [125I] NDP-MSH, as per the hMC5R procedure in Example 102. In-house plasma membranes were prepared from transfected mammalian cells (prepared as in Example 109, using plasmid DNA containing the human MC1R, MC3R or MC4R gene or other gene of interest in a plasmid vector with a mammalian origin of replication): Adherent cells were washed with warm Hanks buffered saline solution (HBSS). 1 mL of cold HBSS was added to each flask and the cells were scraped off with a rubber policeman. The scraped cells were added to a 50 mL tube on ice. The plates were then rinsed twice with 5 mL cold HBSS and this was also added to the tube. The cells were centrifuged at 1000×g for 5 mins in a bench top centrifuge and the supernatant was decanted. The remaining cell pellet was resuspended in 0.25 M sucrose. The cell suspension was centrifuged again as previously and the pellet resuspended in 5 mL of 0.25 M sucrose containing protease inhibitors. The cells were homogenised by a 10 second pulse with an Ika disperser followed by 30 seconds on ice. The homogenisation and ice incubation was repeated three times. The mixture was then centrifuged at 1260×g for 5 mins. The supernatant was decanted into another centrifuge tube, to which a buffer containing 50 mM Tris, pH 7.4, 12.5 mM MgCl2, 5 mM EGTA and protease inhibitors was added to make the volume up to 30 mL. This was centrifuged at 30,000×g for 90 mins at 4° C. The resulting pellet was resuspended in 1 mL of the buffer above also containing 10% glycerol. Membranes were aliquoted into cryovials which were snap-frozen in a dry-ice/ethanol bath before being stored at −80° C. until required for use.	ChEMBL	598	11	2	4	5.7	O=C(/C=C/c1ccc(Cl)cc1)NC[C@H]1CCN(CC(c2ccccc2)c2ccccc2)C(=O)[C@@H](CCN2CCCCC2)N1	nan
	155546131	173506	0	None	-10	3	Mouse	4.8	pIC50	=	4.8	Binding	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL	929	9	8	10	-0.4	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	CHEMBL4531291	173506	0	None	-10	3	Mouse	4.8	pIC50	=	4.8	Binding	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL	929	9	8	10	-0.4	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	2247	504	81	None	-147	42	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	249	504	81	None	-147	42	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	2603	504	81	None	-147	42	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	CHEMBL296419	504	81	None	-147	42	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	DB00637	504	81	None	-147	42	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	CHEMBL186970	209031	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N(CCCCN)CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1021/jm0490033
	145973975	164633	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	901	11	12	9	0.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4216654	164633	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	901	11	12	9	0.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	6918813	131345	3	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Concentration for 50% inhibition of human melanocortin-3 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligandConcentration for 50% inhibition of human melanocortin-3 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligand	ChEMBL	557	7	3	5	2.9	CN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	CHEMBL368876	131345	3	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Concentration for 50% inhibition of human melanocortin-3 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligandConcentration for 50% inhibition of human melanocortin-3 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligand	ChEMBL	557	7	3	5	2.9	CN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	71456245	78947	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 3 receptorInhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 3 receptor	ChEMBL	608	9	2	6	6.2	COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@H]3CNC[C@@H]3c3ccc(F)cc3)C2=O)cc1	10.1016/j.bmcl.2005.06.033
	CHEMBL2113039	78947	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 3 receptorInhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 3 receptor	ChEMBL	608	9	2	6	6.2	COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@H]3CNC[C@@H]3c3ccc(F)cc3)C2=O)cc1	10.1016/j.bmcl.2005.06.033
	122184911	122530	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3601429	122530	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	122184575	122401	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600836	122401	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	10282847	122939	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cells	ChEMBL	634	7	3	4	5.9	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2CCc3ccccc3[C@@]2(C)N)CC1	10.1016/j.bmcl.2005.05.012
	CHEMBL360819	122939	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cells	ChEMBL	634	7	3	4	5.9	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2CCc3ccccc3[C@@]2(C)N)CC1	10.1016/j.bmcl.2005.05.012
	CHEMBL3577981	211726	1	None	-31	3	Mouse	4.8	pIC50	=	4.8	Binding	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	5624	32663	14	None	-45	10	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
	CHEMBL1203324	32663	14	None	-45	10	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
	CHEMBL141343	32663	14	None	-45	10	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
	57854192	153025	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Radioligand Binding Assay: Radioligand binding assays were carried out using commercial or in-house prepared hMC1R, hMC3R and hMC4R membranes and [125I] NDP-MSH, as per the hMC5R procedure in Example 102. In-house plasma membranes were prepared from transfected mammalian cells (prepared as in Example 109, using plasmid DNA containing the human MC1R, MC3R or MC4R gene or other gene of interest in a plasmid vector with a mammalian origin of replication): Adherent cells were washed with warm Hanks buffered saline solution (HBSS). 1 mL of cold HBSS was added to each flask and the cells were scraped off with a rubber policeman. The scraped cells were added to a 50 mL tube on ice. The plates were then rinsed twice with 5 mL cold HBSS and this was also added to the tube. The cells were centrifuged at 1000×g for 5 mins in a bench top centrifuge and the supernatant was decanted. The remaining cell pellet was resuspended in 0.25 M sucrose. The cell suspension was centrifuged again as previously and the pellet resuspended in 5 mL of 0.25 M sucrose containing protease inhibitors. The cells were homogenised by a 10 second pulse with an Ika disperser followed by 30 seconds on ice. The homogenisation and ice incubation was repeated three times. The mixture was then centrifuged at 1260×g for 5 mins. The supernatant was decanted into another centrifuge tube, to which a buffer containing 50 mM Tris, pH 7.4, 12.5 mM MgCl2, 5 mM EGTA and protease inhibitors was added to make the volume up to 30 mL. This was centrifuged at 30,000×g for 90 mins at 4° C. The resulting pellet was resuspended in 1 mL of the buffer above also containing 10% glycerol. Membranes were aliquoted into cryovials which were snap-frozen in a dry-ice/ethanol bath before being stored at −80° C. until required for use.Radioligand Binding Assay: Radioligand binding assays were carried out using commercial or in-house prepared hMC1R, hMC3R and hMC4R membranes and [125I] NDP-MSH, as per the hMC5R procedure in Example 102. In-house plasma membranes were prepared from transfected mammalian cells (prepared as in Example 109, using plasmid DNA containing the human MC1R, MC3R or MC4R gene or other gene of interest in a plasmid vector with a mammalian origin of replication): Adherent cells were washed with warm Hanks buffered saline solution (HBSS). 1 mL of cold HBSS was added to each flask and the cells were scraped off with a rubber policeman. The scraped cells were added to a 50 mL tube on ice. The plates were then rinsed twice with 5 mL cold HBSS and this was also added to the tube. The cells were centrifuged at 1000×g for 5 mins in a bench top centrifuge and the supernatant was decanted. The remaining cell pellet was resuspended in 0.25 M sucrose. The cell suspension was centrifuged again as previously and the pellet resuspended in 5 mL of 0.25 M sucrose containing protease inhibitors. The cells were homogenised by a 10 second pulse with an Ika disperser followed by 30 seconds on ice. The homogenisation and ice incubation was repeated three times. The mixture was then centrifuged at 1260×g for 5 mins. The supernatant was decanted into another centrifuge tube, to which a buffer containing 50 mM Tris, pH 7.4, 12.5 mM MgCl2, 5 mM EGTA and protease inhibitors was added to make the volume up to 30 mL. This was centrifuged at 30,000×g for 90 mins at 4° C. The resulting pellet was resuspended in 1 mL of the buffer above also containing 10% glycerol. Membranes were aliquoted into cryovials which were snap-frozen in a dry-ice/ethanol bath before being stored at −80° C. until required for use.	ChEMBL	576	11	5	4	4.2	N=C(N)NCCC[C@H]1N[C@@H](CNC(=O)c2ccc3ccccc3c2)CCN(CC(c2ccccc2)c2ccccc2)C1=O	nan
	CHEMBL3975851	153025	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Radioligand Binding Assay: Radioligand binding assays were carried out using commercial or in-house prepared hMC1R, hMC3R and hMC4R membranes and [125I] NDP-MSH, as per the hMC5R procedure in Example 102. In-house plasma membranes were prepared from transfected mammalian cells (prepared as in Example 109, using plasmid DNA containing the human MC1R, MC3R or MC4R gene or other gene of interest in a plasmid vector with a mammalian origin of replication): Adherent cells were washed with warm Hanks buffered saline solution (HBSS). 1 mL of cold HBSS was added to each flask and the cells were scraped off with a rubber policeman. The scraped cells were added to a 50 mL tube on ice. The plates were then rinsed twice with 5 mL cold HBSS and this was also added to the tube. The cells were centrifuged at 1000×g for 5 mins in a bench top centrifuge and the supernatant was decanted. The remaining cell pellet was resuspended in 0.25 M sucrose. The cell suspension was centrifuged again as previously and the pellet resuspended in 5 mL of 0.25 M sucrose containing protease inhibitors. The cells were homogenised by a 10 second pulse with an Ika disperser followed by 30 seconds on ice. The homogenisation and ice incubation was repeated three times. The mixture was then centrifuged at 1260×g for 5 mins. The supernatant was decanted into another centrifuge tube, to which a buffer containing 50 mM Tris, pH 7.4, 12.5 mM MgCl2, 5 mM EGTA and protease inhibitors was added to make the volume up to 30 mL. This was centrifuged at 30,000×g for 90 mins at 4° C. The resulting pellet was resuspended in 1 mL of the buffer above also containing 10% glycerol. Membranes were aliquoted into cryovials which were snap-frozen in a dry-ice/ethanol bath before being stored at −80° C. until required for use.Radioligand Binding Assay: Radioligand binding assays were carried out using commercial or in-house prepared hMC1R, hMC3R and hMC4R membranes and [125I] NDP-MSH, as per the hMC5R procedure in Example 102. In-house plasma membranes were prepared from transfected mammalian cells (prepared as in Example 109, using plasmid DNA containing the human MC1R, MC3R or MC4R gene or other gene of interest in a plasmid vector with a mammalian origin of replication): Adherent cells were washed with warm Hanks buffered saline solution (HBSS). 1 mL of cold HBSS was added to each flask and the cells were scraped off with a rubber policeman. The scraped cells were added to a 50 mL tube on ice. The plates were then rinsed twice with 5 mL cold HBSS and this was also added to the tube. The cells were centrifuged at 1000×g for 5 mins in a bench top centrifuge and the supernatant was decanted. The remaining cell pellet was resuspended in 0.25 M sucrose. The cell suspension was centrifuged again as previously and the pellet resuspended in 5 mL of 0.25 M sucrose containing protease inhibitors. The cells were homogenised by a 10 second pulse with an Ika disperser followed by 30 seconds on ice. The homogenisation and ice incubation was repeated three times. The mixture was then centrifuged at 1260×g for 5 mins. The supernatant was decanted into another centrifuge tube, to which a buffer containing 50 mM Tris, pH 7.4, 12.5 mM MgCl2, 5 mM EGTA and protease inhibitors was added to make the volume up to 30 mL. This was centrifuged at 30,000×g for 90 mins at 4° C. The resulting pellet was resuspended in 1 mL of the buffer above also containing 10% glycerol. Membranes were aliquoted into cryovials which were snap-frozen in a dry-ice/ethanol bath before being stored at −80° C. until required for use.	ChEMBL	576	11	5	4	4.2	N=C(N)NCCC[C@H]1N[C@@H](CNC(=O)c2ccc3ccccc3c2)CCN(CC(c2ccccc2)c2ccccc2)C1=O	nan
	127053937	149029	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Radioligand Binding Assay: Radioligand binding assays were carried out using commercial or in-house prepared hMC1R, hMC3R and hMC4R membranes and [125I] NDP-MSH, as per the hMC5R procedure in Example 102. In-house plasma membranes were prepared from transfected mammalian cells (prepared as in Example 109, using plasmid DNA containing the human MC1R, MC3R or MC4R gene or other gene of interest in a plasmid vector with a mammalian origin of replication): Adherent cells were washed with warm Hanks buffered saline solution (HBSS). 1 mL of cold HBSS was added to each flask and the cells were scraped off with a rubber policeman. The scraped cells were added to a 50 mL tube on ice. The plates were then rinsed twice with 5 mL cold HBSS and this was also added to the tube. The cells were centrifuged at 1000×g for 5 mins in a bench top centrifuge and the supernatant was decanted. The remaining cell pellet was resuspended in 0.25 M sucrose. The cell suspension was centrifuged again as previously and the pellet resuspended in 5 mL of 0.25 M sucrose containing protease inhibitors. The cells were homogenised by a 10 second pulse with an Ika disperser followed by 30 seconds on ice. The homogenisation and ice incubation was repeated three times. The mixture was then centrifuged at 1260×g for 5 mins. The supernatant was decanted into another centrifuge tube, to which a buffer containing 50 mM Tris, pH 7.4, 12.5 mM MgCl2, 5 mM EGTA and protease inhibitors was added to make the volume up to 30 mL. This was centrifuged at 30,000×g for 90 mins at 4° C. The resulting pellet was resuspended in 1 mL of the buffer above also containing 10% glycerol. Membranes were aliquoted into cryovials which were snap-frozen in a dry-ice/ethanol bath before being stored at −80° C. until required for use.Radioligand Binding Assay: Radioligand binding assays were carried out using commercial or in-house prepared hMC1R, hMC3R and hMC4R membranes and [125I] NDP-MSH, as per the hMC5R procedure in Example 102. In-house plasma membranes were prepared from transfected mammalian cells (prepared as in Example 109, using plasmid DNA containing the human MC1R, MC3R or MC4R gene or other gene of interest in a plasmid vector with a mammalian origin of replication): Adherent cells were washed with warm Hanks buffered saline solution (HBSS). 1 mL of cold HBSS was added to each flask and the cells were scraped off with a rubber policeman. The scraped cells were added to a 50 mL tube on ice. The plates were then rinsed twice with 5 mL cold HBSS and this was also added to the tube. The cells were centrifuged at 1000×g for 5 mins in a bench top centrifuge and the supernatant was decanted. The remaining cell pellet was resuspended in 0.25 M sucrose. The cell suspension was centrifuged again as previously and the pellet resuspended in 5 mL of 0.25 M sucrose containing protease inhibitors. The cells were homogenised by a 10 second pulse with an Ika disperser followed by 30 seconds on ice. The homogenisation and ice incubation was repeated three times. The mixture was then centrifuged at 1260×g for 5 mins. The supernatant was decanted into another centrifuge tube, to which a buffer containing 50 mM Tris, pH 7.4, 12.5 mM MgCl2, 5 mM EGTA and protease inhibitors was added to make the volume up to 30 mL. This was centrifuged at 30,000×g for 90 mins at 4° C. The resulting pellet was resuspended in 1 mL of the buffer above also containing 10% glycerol. Membranes were aliquoted into cryovials which were snap-frozen in a dry-ice/ethanol bath before being stored at −80° C. until required for use.	ChEMBL	502	11	2	4	4.3	CCC(CC)CN1CC[C@H](CNC(=O)/C=C/c2ccc(Cl)cc2)N[C@H](CCN2CCCCC2)C1=O	nan
	CHEMBL3942822	149029	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Radioligand Binding Assay: Radioligand binding assays were carried out using commercial or in-house prepared hMC1R, hMC3R and hMC4R membranes and [125I] NDP-MSH, as per the hMC5R procedure in Example 102. In-house plasma membranes were prepared from transfected mammalian cells (prepared as in Example 109, using plasmid DNA containing the human MC1R, MC3R or MC4R gene or other gene of interest in a plasmid vector with a mammalian origin of replication): Adherent cells were washed with warm Hanks buffered saline solution (HBSS). 1 mL of cold HBSS was added to each flask and the cells were scraped off with a rubber policeman. The scraped cells were added to a 50 mL tube on ice. The plates were then rinsed twice with 5 mL cold HBSS and this was also added to the tube. The cells were centrifuged at 1000×g for 5 mins in a bench top centrifuge and the supernatant was decanted. The remaining cell pellet was resuspended in 0.25 M sucrose. The cell suspension was centrifuged again as previously and the pellet resuspended in 5 mL of 0.25 M sucrose containing protease inhibitors. The cells were homogenised by a 10 second pulse with an Ika disperser followed by 30 seconds on ice. The homogenisation and ice incubation was repeated three times. The mixture was then centrifuged at 1260×g for 5 mins. The supernatant was decanted into another centrifuge tube, to which a buffer containing 50 mM Tris, pH 7.4, 12.5 mM MgCl2, 5 mM EGTA and protease inhibitors was added to make the volume up to 30 mL. This was centrifuged at 30,000×g for 90 mins at 4° C. The resulting pellet was resuspended in 1 mL of the buffer above also containing 10% glycerol. Membranes were aliquoted into cryovials which were snap-frozen in a dry-ice/ethanol bath before being stored at −80° C. until required for use.Radioligand Binding Assay: Radioligand binding assays were carried out using commercial or in-house prepared hMC1R, hMC3R and hMC4R membranes and [125I] NDP-MSH, as per the hMC5R procedure in Example 102. In-house plasma membranes were prepared from transfected mammalian cells (prepared as in Example 109, using plasmid DNA containing the human MC1R, MC3R or MC4R gene or other gene of interest in a plasmid vector with a mammalian origin of replication): Adherent cells were washed with warm Hanks buffered saline solution (HBSS). 1 mL of cold HBSS was added to each flask and the cells were scraped off with a rubber policeman. The scraped cells were added to a 50 mL tube on ice. The plates were then rinsed twice with 5 mL cold HBSS and this was also added to the tube. The cells were centrifuged at 1000×g for 5 mins in a bench top centrifuge and the supernatant was decanted. The remaining cell pellet was resuspended in 0.25 M sucrose. The cell suspension was centrifuged again as previously and the pellet resuspended in 5 mL of 0.25 M sucrose containing protease inhibitors. The cells were homogenised by a 10 second pulse with an Ika disperser followed by 30 seconds on ice. The homogenisation and ice incubation was repeated three times. The mixture was then centrifuged at 1260×g for 5 mins. The supernatant was decanted into another centrifuge tube, to which a buffer containing 50 mM Tris, pH 7.4, 12.5 mM MgCl2, 5 mM EGTA and protease inhibitors was added to make the volume up to 30 mL. This was centrifuged at 30,000×g for 90 mins at 4° C. The resulting pellet was resuspended in 1 mL of the buffer above also containing 10% glycerol. Membranes were aliquoted into cryovials which were snap-frozen in a dry-ice/ethanol bath before being stored at −80° C. until required for use.	ChEMBL	502	11	2	4	4.3	CCC(CC)CN1CC[C@H](CNC(=O)/C=C/c2ccc(Cl)cc2)N[C@H](CCN2CCCCC2)C1=O	nan
	4189	206899	96	None	-54	34	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL1559	206899	96	None	-54	34	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL91	206899	96	None	-54	34	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	1338	3778	43	None	-	4	Rat	5.7	pIC50	=	5.7	Binding	Evaluated for binding affinity against rat Melanocortin-3 receptor (rMC3R) by displacing [125I]-NDP-alpha-MSH radioligand expressed in CHO cellsEvaluated for binding affinity against rat Melanocortin-3 receptor (rMC3R) by displacing [125I]-NDP-alpha-MSH radioligand expressed in CHO cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	9938402	3778	43	None	-	4	Rat	5.7	pIC50	=	5.7	Binding	Evaluated for binding affinity against rat Melanocortin-3 receptor (rMC3R) by displacing [125I]-NDP-alpha-MSH radioligand expressed in CHO cellsEvaluated for binding affinity against rat Melanocortin-3 receptor (rMC3R) by displacing [125I]-NDP-alpha-MSH radioligand expressed in CHO cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	CHEMBL339053	3778	43	None	-	4	Rat	5.7	pIC50	=	5.7	Binding	Evaluated for binding affinity against rat Melanocortin-3 receptor (rMC3R) by displacing [125I]-NDP-alpha-MSH radioligand expressed in CHO cellsEvaluated for binding affinity against rat Melanocortin-3 receptor (rMC3R) by displacing [125I]-NDP-alpha-MSH radioligand expressed in CHO cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	16132144	209256	36	None	-30	4	Human	7.7	pIC50	=	7.7	Binding	Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2005.05.109
	16133793	209256	36	None	-30	4	Human	7.7	pIC50	=	7.7	Binding	Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2005.05.109
	44273719	209256	36	None	-30	4	Human	7.7	pIC50	=	7.7	Binding	Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2005.05.109
	CHEMBL214332	209256	36	None	-30	4	Human	7.7	pIC50	=	7.7	Binding	Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1016/j.bmcl.2005.05.109
	CHEMBL3600840	211794	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL1161321	208484	0	None	-19	2	Human	6.7	pIC50	=	6.7	Binding	Binding affinity for human Melanocortin-3 receptorBinding affinity for human Melanocortin-3 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(Cc3ccccc3C2)NC1=O	10.1021/jm0202526
	44577514	172431	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cellsDisplacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells	ChEMBL	943	12	11	11	1.6	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	CHEMBL448081	172431	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cellsDisplacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells	ChEMBL	943	12	11	11	1.6	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	CHEMBL2112008	209203	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Binding affinity for Human Melanocortin 3 receptor expressed in L-cellsBinding affinity for Human Melanocortin 3 receptor expressed in L-cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	CHEMBL2221249	209420	0	None	1	3	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL		None	None	None		CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O	nan
	1016	3720	78	None	-56	35	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2561	3720	78	None	-56	35	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2733526	3720	78	None	-56	35	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	5384	3720	78	None	-56	35	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	CHEMBL83	3720	78	None	-56	35	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	DB00675	3720	78	None	-56	35	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	CHEMBL365913	212020	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1021/jm0490033
	CHEMBL190427	209042	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N(CCCCN)CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N(CC(=O)NCC(N)=O)Cc1c[nH]c2ccccc12)C(C)=O	10.1021/jm0490033
	CHEMBL190551	209043	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O	10.1021/jm0490033
	1323	2669	55	None	-72	3	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells by gamma counting analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells by gamma counting analysis	ChEMBL		None	None	None		None	10.1021/ml500436s
	92432	2669	55	None	-72	3	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells by gamma counting analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells by gamma counting analysis	ChEMBL		None	None	None		None	10.1021/ml500436s
	CHEMBL430239	2669	55	None	-72	3	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells by gamma counting analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells by gamma counting analysis	ChEMBL		None	None	None		None	10.1021/ml500436s
	1323	2669	55	None	-72	3	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting analysisDisplacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting analysis	ChEMBL		None	None	None		None	10.1016/j.ejmech.2018.04.021
	92432	2669	55	None	-72	3	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting analysisDisplacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting analysis	ChEMBL		None	None	None		None	10.1016/j.ejmech.2018.04.021
	CHEMBL430239	2669	55	None	-72	3	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting analysisDisplacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting analysis	ChEMBL		None	None	None		None	10.1016/j.ejmech.2018.04.021
	1323	2669	55	None	-72	3	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]NDP-alphaMSH from human MC3 receptor expressed in HEK293 cellsDisplacement of [125I]NDP-alphaMSH from human MC3 receptor expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm060768f
	92432	2669	55	None	-72	3	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]NDP-alphaMSH from human MC3 receptor expressed in HEK293 cellsDisplacement of [125I]NDP-alphaMSH from human MC3 receptor expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm060768f
	CHEMBL430239	2669	55	None	-72	3	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]NDP-alphaMSH from human MC3 receptor expressed in HEK293 cellsDisplacement of [125I]NDP-alphaMSH from human MC3 receptor expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm060768f
	CHEMBL503229	214140	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm801300c
	CHEMBL443071	213897	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON	10.1021/jm049579s
	145967155	164219	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	901	11	12	9	0.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4211275	164219	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	901	11	12	9	0.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL502300	214129	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2C[C@H](NC(=N)N)CN2C1=O	10.1021/jm801300c
	CHEMBL2096742	209183	0	None	-5	2	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm801300c
	CHEMBL501592	214118	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2C[C@@H](NC(=N)N)CN2C1=O	10.1021/jm801300c
	CHEMBL3752534	212193	1	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysisDisplacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysis	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C1=O	10.1021/acs.jmedchem.5b01285
	CHEMBL1161320	208483	0	None	12	2	Human	8.6	pIC50	=	8.6	Binding	Binding affinity for human Melanocortin-3 receptorBinding affinity for human Melanocortin-3 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(CC2)NC1=O	10.1021/jm0202526
	CHEMBL1161323	208486	0	None	-5	2	Human	8.6	pIC50	=	8.6	Binding	Binding affinity for human Melanocortin-3 receptorBinding affinity for human Melanocortin-3 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2C[C@@]3(C)CCCC[C@@]3(C)N2C1=O	10.1021/jm0202526
	122184637	122410	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600918	122410	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL204263	209140	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibitory activity against hMC3R transfected in HEK293 cellsInhibitory activity against hMC3R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](CCCN=C(N)N)NC1=O	10.1021/jm0510326
	CHEMBL524861	215600	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@H](NC(=N)N)CN2C1=O	10.1021/jm801300c
	1324	301	25	None	-2	4	Human	8.5	pIC50	=	8.5	Binding	Binding affinity for Human Melanocortin 3 receptor expressed in L-cellsBinding affinity for Human Melanocortin 3 receptor expressed in L-cells	ChEMBL		None	None	None		None	10.1021/jm000211e
	16154396	301	25	None	-2	4	Human	8.5	pIC50	=	8.5	Binding	Binding affinity for Human Melanocortin 3 receptor expressed in L-cellsBinding affinity for Human Melanocortin 3 receptor expressed in L-cells	ChEMBL		None	None	None		None	10.1021/jm000211e
	16197727	301	25	None	-2	4	Human	8.5	pIC50	=	8.5	Binding	Binding affinity for Human Melanocortin 3 receptor expressed in L-cellsBinding affinity for Human Melanocortin 3 receptor expressed in L-cells	ChEMBL		None	None	None		None	10.1021/jm000211e
	44285019	301	25	None	-2	4	Human	8.5	pIC50	=	8.5	Binding	Binding affinity for Human Melanocortin 3 receptor expressed in L-cellsBinding affinity for Human Melanocortin 3 receptor expressed in L-cells	ChEMBL		None	None	None		None	10.1021/jm000211e
	57514683	301	25	None	-2	4	Human	8.5	pIC50	=	8.5	Binding	Binding affinity for Human Melanocortin 3 receptor expressed in L-cellsBinding affinity for Human Melanocortin 3 receptor expressed in L-cells	ChEMBL		None	None	None		None	10.1021/jm000211e
	91898441	301	25	None	-2	4	Human	8.5	pIC50	=	8.5	Binding	Binding affinity for Human Melanocortin 3 receptor expressed in L-cellsBinding affinity for Human Melanocortin 3 receptor expressed in L-cells	ChEMBL		None	None	None		None	10.1021/jm000211e
	CHEMBL441738	301	25	None	-2	4	Human	8.5	pIC50	=	8.5	Binding	Binding affinity for Human Melanocortin 3 receptor expressed in L-cellsBinding affinity for Human Melanocortin 3 receptor expressed in L-cells	ChEMBL		None	None	None		None	10.1021/jm000211e
	DB04931	301	25	None	-2	4	Human	8.5	pIC50	=	8.5	Binding	Binding affinity for Human Melanocortin 3 receptor expressed in L-cellsBinding affinity for Human Melanocortin 3 receptor expressed in L-cells	ChEMBL		None	None	None		None	10.1021/jm000211e
	145975465	163925	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	825	11	12	9	-1.6	CC1(C)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4207725	163925	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	825	11	12	9	-1.6	CC1(C)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	122184910	122529	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3601428	122529	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	24774521	154234	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	861	9	10	8	0.6	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)/C=C\C(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL398635	154234	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	861	9	10	8	0.6	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)/C=C\C(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL3600832	211790	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	71456219	78718	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL	1533	33	16	22	-1.3	CC(=O)[C@H]1CSSC[C@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	CHEMBL2112603	78718	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL	1533	33	16	22	-1.3	CC(=O)[C@H]1CSSC[C@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	44396986	67402	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	568	7	3	4	4.3	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H]2C[C@H]3CC[C@@H]2NC3)CC1	10.1016/j.bmcl.2005.05.109
	CHEMBL188966	67402	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	568	7	3	4	4.3	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H]2C[C@H]3CC[C@@H]2NC3)CC1	10.1016/j.bmcl.2005.05.109
	44408287	75357	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	620	8	2	5	5.1	C[C@@H]1COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.11.095
	CHEMBL203911	75357	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	620	8	2	5	5.1	C[C@@H]1COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.11.095
	15953838	67240	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Concentration required to inhibit binding of [125I]NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-3-receptor (MC3R)Concentration required to inhibit binding of [125I]NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-3-receptor (MC3R)	ChEMBL	602	10	2	7	5.9	COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccccc3)c2=O)cc1	10.1016/j.bmcl.2003.09.026
	CHEMBL188146	67240	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Concentration required to inhibit binding of [125I]NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-3-receptor (MC3R)Concentration required to inhibit binding of [125I]NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-3-receptor (MC3R)	ChEMBL	602	10	2	7	5.9	COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccccc3)c2=O)cc1	10.1016/j.bmcl.2003.09.026
	CHEMBL539306	67240	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Concentration required to inhibit binding of [125I]NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-3-receptor (MC3R)Concentration required to inhibit binding of [125I]NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-3-receptor (MC3R)	ChEMBL	602	10	2	7	5.9	COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccccc3)c2=O)cc1	10.1016/j.bmcl.2003.09.026
	168282779	191147	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assay	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(N)=O)CSCc2ccccc2CSC1(C)C	10.1021/acs.jmedchem.1c01848
	CHEMBL5188894	191147	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assay	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(N)=O)CSCc2ccccc2CSC1(C)C	10.1021/acs.jmedchem.1c01848
	CHEMBL3600920	211800	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	145988152	167020	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting analysisDisplacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting analysis	ChEMBL	720	17	7	6	2.3	CCCC[C@H](NC(=O)[C@@H](Cc1ccc(Br)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	CHEMBL4288909	167020	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting analysisDisplacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting analysis	ChEMBL	720	17	7	6	2.3	CCCC[C@H](NC(=O)[C@@H](Cc1ccc(Br)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	127053935	144160	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Radioligand Binding Assay: Radioligand binding assays were carried out using commercial or in-house prepared hMC1R, hMC3R and hMC4R membranes and [125I] NDP-MSH, as per the hMC5R procedure in Example 102. In-house plasma membranes were prepared from transfected mammalian cells (prepared as in Example 109, using plasmid DNA containing the human MC1R, MC3R or MC4R gene or other gene of interest in a plasmid vector with a mammalian origin of replication): Adherent cells were washed with warm Hanks buffered saline solution (HBSS). 1 mL of cold HBSS was added to each flask and the cells were scraped off with a rubber policeman. The scraped cells were added to a 50 mL tube on ice. The plates were then rinsed twice with 5 mL cold HBSS and this was also added to the tube. The cells were centrifuged at 1000×g for 5 mins in a bench top centrifuge and the supernatant was decanted. The remaining cell pellet was resuspended in 0.25 M sucrose. The cell suspension was centrifuged again as previously and the pellet resuspended in 5 mL of 0.25 M sucrose containing protease inhibitors. The cells were homogenised by a 10 second pulse with an Ika disperser followed by 30 seconds on ice. The homogenisation and ice incubation was repeated three times. The mixture was then centrifuged at 1260×g for 5 mins. The supernatant was decanted into another centrifuge tube, to which a buffer containing 50 mM Tris, pH 7.4, 12.5 mM MgCl2, 5 mM EGTA and protease inhibitors was added to make the volume up to 30 mL. This was centrifuged at 30,000×g for 90 mins at 4° C. The resulting pellet was resuspended in 1 mL of the buffer above also containing 10% glycerol. Membranes were aliquoted into cryovials which were snap-frozen in a dry-ice/ethanol bath before being stored at −80° C. until required for use.Radioligand Binding Assay: Radioligand binding assays were carried out using commercial or in-house prepared hMC1R, hMC3R and hMC4R membranes and [125I] NDP-MSH, as per the hMC5R procedure in Example 102. In-house plasma membranes were prepared from transfected mammalian cells (prepared as in Example 109, using plasmid DNA containing the human MC1R, MC3R or MC4R gene or other gene of interest in a plasmid vector with a mammalian origin of replication): Adherent cells were washed with warm Hanks buffered saline solution (HBSS). 1 mL of cold HBSS was added to each flask and the cells were scraped off with a rubber policeman. The scraped cells were added to a 50 mL tube on ice. The plates were then rinsed twice with 5 mL cold HBSS and this was also added to the tube. The cells were centrifuged at 1000×g for 5 mins in a bench top centrifuge and the supernatant was decanted. The remaining cell pellet was resuspended in 0.25 M sucrose. The cell suspension was centrifuged again as previously and the pellet resuspended in 5 mL of 0.25 M sucrose containing protease inhibitors. The cells were homogenised by a 10 second pulse with an Ika disperser followed by 30 seconds on ice. The homogenisation and ice incubation was repeated three times. The mixture was then centrifuged at 1260×g for 5 mins. The supernatant was decanted into another centrifuge tube, to which a buffer containing 50 mM Tris, pH 7.4, 12.5 mM MgCl2, 5 mM EGTA and protease inhibitors was added to make the volume up to 30 mL. This was centrifuged at 30,000×g for 90 mins at 4° C. The resulting pellet was resuspended in 1 mL of the buffer above also containing 10% glycerol. Membranes were aliquoted into cryovials which were snap-frozen in a dry-ice/ethanol bath before being stored at −80° C. until required for use.	ChEMBL	602	11	2	4	6.2	O=C(NC[C@H]1CCN(CC(c2ccccc2)c2ccccc2)C(=O)[C@@H](CCCN2CCCCC2)N1)c1ccc2ccccc2c1	nan
	CHEMBL3904191	144160	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Radioligand Binding Assay: Radioligand binding assays were carried out using commercial or in-house prepared hMC1R, hMC3R and hMC4R membranes and [125I] NDP-MSH, as per the hMC5R procedure in Example 102. In-house plasma membranes were prepared from transfected mammalian cells (prepared as in Example 109, using plasmid DNA containing the human MC1R, MC3R or MC4R gene or other gene of interest in a plasmid vector with a mammalian origin of replication): Adherent cells were washed with warm Hanks buffered saline solution (HBSS). 1 mL of cold HBSS was added to each flask and the cells were scraped off with a rubber policeman. The scraped cells were added to a 50 mL tube on ice. The plates were then rinsed twice with 5 mL cold HBSS and this was also added to the tube. The cells were centrifuged at 1000×g for 5 mins in a bench top centrifuge and the supernatant was decanted. The remaining cell pellet was resuspended in 0.25 M sucrose. The cell suspension was centrifuged again as previously and the pellet resuspended in 5 mL of 0.25 M sucrose containing protease inhibitors. The cells were homogenised by a 10 second pulse with an Ika disperser followed by 30 seconds on ice. The homogenisation and ice incubation was repeated three times. The mixture was then centrifuged at 1260×g for 5 mins. The supernatant was decanted into another centrifuge tube, to which a buffer containing 50 mM Tris, pH 7.4, 12.5 mM MgCl2, 5 mM EGTA and protease inhibitors was added to make the volume up to 30 mL. This was centrifuged at 30,000×g for 90 mins at 4° C. The resulting pellet was resuspended in 1 mL of the buffer above also containing 10% glycerol. Membranes were aliquoted into cryovials which were snap-frozen in a dry-ice/ethanol bath before being stored at −80° C. until required for use.Radioligand Binding Assay: Radioligand binding assays were carried out using commercial or in-house prepared hMC1R, hMC3R and hMC4R membranes and [125I] NDP-MSH, as per the hMC5R procedure in Example 102. In-house plasma membranes were prepared from transfected mammalian cells (prepared as in Example 109, using plasmid DNA containing the human MC1R, MC3R or MC4R gene or other gene of interest in a plasmid vector with a mammalian origin of replication): Adherent cells were washed with warm Hanks buffered saline solution (HBSS). 1 mL of cold HBSS was added to each flask and the cells were scraped off with a rubber policeman. The scraped cells were added to a 50 mL tube on ice. The plates were then rinsed twice with 5 mL cold HBSS and this was also added to the tube. The cells were centrifuged at 1000×g for 5 mins in a bench top centrifuge and the supernatant was decanted. The remaining cell pellet was resuspended in 0.25 M sucrose. The cell suspension was centrifuged again as previously and the pellet resuspended in 5 mL of 0.25 M sucrose containing protease inhibitors. The cells were homogenised by a 10 second pulse with an Ika disperser followed by 30 seconds on ice. The homogenisation and ice incubation was repeated three times. The mixture was then centrifuged at 1260×g for 5 mins. The supernatant was decanted into another centrifuge tube, to which a buffer containing 50 mM Tris, pH 7.4, 12.5 mM MgCl2, 5 mM EGTA and protease inhibitors was added to make the volume up to 30 mL. This was centrifuged at 30,000×g for 90 mins at 4° C. The resulting pellet was resuspended in 1 mL of the buffer above also containing 10% glycerol. Membranes were aliquoted into cryovials which were snap-frozen in a dry-ice/ethanol bath before being stored at −80° C. until required for use.	ChEMBL	602	11	2	4	6.2	O=C(NC[C@H]1CCN(CC(c2ccccc2)c2ccccc2)C(=O)[C@@H](CCCN2CCCCC2)N1)c1ccc2ccccc2c1	nan
	CHEMBL217305	209350	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human melanocortin 3 receptor (hMC3R) using [125I]NDP-alpha-MSH as radioligandBinding affinity towards human melanocortin 3 receptor (hMC3R) using [125I]NDP-alpha-MSH as radioligand	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O	10.1016/s0960-894x(03)00412-8
	122184499	122367	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1088	17	13	11	0.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600737	122367	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1088	17	13	11	0.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	24774438	94826	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	816	9	10	9	0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)c2nccnc2C(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL253789	94826	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	816	9	10	9	0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)c2nccnc2C(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	9808801	60779	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	599	8	3	4	5.0	CC[C@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](CC)N1	10.1016/j.bmcl.2011.02.090
	CHEMBL1761871	60779	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	599	8	3	4	5.0	CC[C@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](CC)N1	10.1016/j.bmcl.2011.02.090
	44408286	140643	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	634	8	2	5	5.5	CC1(C)COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.11.095
	CHEMBL381501	140643	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	634	8	2	5	5.5	CC1(C)COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.11.095
	6918813	131345	3	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Concentration for 50% inhibition of human melanocortin-3 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligandConcentration for 50% inhibition of human melanocortin-3 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligand	ChEMBL	557	7	3	5	2.9	CN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	CHEMBL368876	131345	3	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Concentration for 50% inhibition of human melanocortin-3 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligandConcentration for 50% inhibition of human melanocortin-3 receptor expressed in CHO cells using [125I]NDP-alpha-MSH as radioligand	ChEMBL	557	7	3	5	2.9	CN1CCN[C@H](C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C1	10.1016/j.bmcl.2004.10.020
	168273822	190546	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assay	ChEMBL	1106	17	13	12	1.5	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccc(cc2)CSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	CHEMBL5180152	190546	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assay	ChEMBL	1106	17	13	12	1.5	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccc(cc2)CSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	122184578	122404	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600839	122404	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL217584	209354	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm960845e
	2726	916	68	None	-186	73	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	621	916	68	None	-186	73	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	83	916	68	None	-186	73	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	CHEMBL71	916	68	None	-186	73	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	DB00477	916	68	None	-186	73	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	168285801	191457	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assay	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(N)=O)CSCc2cccc(c2)CSC1(C)C	10.1021/acs.jmedchem.1c01848
	CHEMBL5193501	191457	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assay	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(N)=O)CSCc2cccc(c2)CSC1(C)C	10.1021/acs.jmedchem.1c01848
	44347840	161900	0	None	-17	3	Human	7.6	pIC50	=	7.6	Binding	Binding affinity for human Melanocortin-3 receptorBinding affinity for human Melanocortin-3 receptor	ChEMBL	1590	33	17	23	-2.2	CC(=O)[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm0202526
	91932630	161900	0	None	-17	3	Human	7.6	pIC50	=	7.6	Binding	Binding affinity for human Melanocortin-3 receptorBinding affinity for human Melanocortin-3 receptor	ChEMBL	1590	33	17	23	-2.2	CC(=O)[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm0202526
	CHEMBL415333	161900	0	None	-17	3	Human	7.6	pIC50	=	7.6	Binding	Binding affinity for human Melanocortin-3 receptorBinding affinity for human Melanocortin-3 receptor	ChEMBL	1590	33	17	23	-2.2	CC(=O)[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm0202526
	CHEMBL2096759	209185	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON	10.1021/jm049579s
	CHEMBL2115441	209245	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm960845e
	CHEMBL380638	212248	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory activity against hMC3R transfected in HEK293 cellsInhibitory activity against hMC3R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCC)NC1=O	10.1021/jm0510326
	137651071	157443	0	None	-	1	Mouse	5.6	pIC50	=	5.6	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL	794	15	7	6	1.3	CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4079298	157443	0	None	-	1	Mouse	5.6	pIC50	=	5.6	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL	794	15	7	6	1.3	CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	145976444	163939	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	889	11	12	9	-0.1	CC1(C)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4207858	163939	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	889	11	12	9	-0.1	CC1(C)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL3600834	211792	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL2371966	210140	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]NDPalphaMSH from human cloned MC3R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC3R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2C(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/jm0614275
	CHEMBL203602	209137	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory activity against hMC3R transfected in HEK293 cellsInhibitory activity against hMC3R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCC(N)=O)NC1=O	10.1021/jm0510326
	CHEMBL381739	212269	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibitory activity against hMC3R transfected in HEK293 cellsInhibitory activity against hMC3R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O	10.1021/jm0510326
	CHEMBL3349030	211382	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Binding affinity for Human Melanocortin 3 receptor expressed in L-cellsBinding affinity for Human Melanocortin 3 receptor expressed in L-cells	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	6918707	104165	1	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Binding affinity towards human melanocortin 3 receptor (hMC3R) using [125I]NDP-alpha-MSH as radioligandBinding affinity towards human melanocortin 3 receptor (hMC3R) using [125I]NDP-alpha-MSH as radioligand	ChEMBL	601	14	5	4	3.7	CC(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCCNC(=N)N)C1CCC(N(CCc2c[nH]c3ccccc23)C(C)=O)CC1	10.1016/s0960-894x(03)00412-8
	CHEMBL309807	104165	1	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Binding affinity towards human melanocortin 3 receptor (hMC3R) using [125I]NDP-alpha-MSH as radioligandBinding affinity towards human melanocortin 3 receptor (hMC3R) using [125I]NDP-alpha-MSH as radioligand	ChEMBL	601	14	5	4	3.7	CC(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCCNC(=N)N)C1CCC(N(CCc2c[nH]c3ccccc23)C(C)=O)CC1	10.1016/s0960-894x(03)00412-8
	155561116	174949	0	None	-10	4	Mouse	4.6	pIC50	=	4.6	Binding	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL	964	11	11	11	-1.4	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	CHEMBL4566163	174949	0	None	-10	4	Mouse	4.6	pIC50	=	4.6	Binding	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL	964	11	11	11	-1.4	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	44431512	145899	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]NDPalphaMSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDPalphaMSH from human MC3R expressed in HEK293 cells	ChEMBL	1038	14	12	10	0.9	CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(Cl)cc2)N2Cc3ccccc3CC(NC1=O)C2=O	10.1016/j.bmcl.2007.02.020
	CHEMBL391796	145899	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]NDPalphaMSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDPalphaMSH from human MC3R expressed in HEK293 cells	ChEMBL	1038	14	12	10	0.9	CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(Cl)cc2)N2Cc3ccccc3CC(NC1=O)C2=O	10.1016/j.bmcl.2007.02.020
	CHEMBL2372588	210249	0	None	-316	2	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human Melanocortin-3 receptorBinding affinity for human Melanocortin-3 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2Cc3ccccc3N2C1=O	10.1021/jm0202526
	44348144	157798	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL	1533	33	16	22	-1.3	CC(=O)C1CSSCC(C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	CHEMBL408336	157798	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL	1533	33	16	22	-1.3	CC(=O)C1CSSCC(C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	44349173	116964	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against human melanocortin 3 receptorInhibitory activity against human melanocortin 3 receptor	ChEMBL	606	6	2	5	3.4	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)c2ccccc21	10.1016/j.bmcl.2003.10.056
	CHEMBL338768	116964	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against human melanocortin 3 receptorInhibitory activity against human melanocortin 3 receptor	ChEMBL	606	6	2	5	3.4	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)c2ccccc21	10.1016/j.bmcl.2003.10.056
	44448631	95041	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	619	6	1	3	7.0	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(Br)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL255286	95041	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	619	6	1	3	7.0	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(Br)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	44448590	95570	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	571	7	1	4	6.3	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(OC)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL257759	95570	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	571	7	1	4	6.3	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(OC)cc2F)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL2371712	210086	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON	10.1021/jm049579s
	44347838	96614	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL	1561	33	16	22	-0.6	CC(=O)C1C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NC(C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)CSSC1(C)C	10.1021/jm030111j
	CHEMBL263585	96614	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL	1561	33	16	22	-0.6	CC(=O)C1C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NC(C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)CSSC1(C)C	10.1021/jm030111j
	CHEMBL3600835	211793	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL2096742	209183	0	None	-5	2	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm070461w
	1324	301	25	None	-2	4	Human	8.5	pIC50	=	8.5	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	16154396	301	25	None	-2	4	Human	8.5	pIC50	=	8.5	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	16197727	301	25	None	-2	4	Human	8.5	pIC50	=	8.5	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	44285019	301	25	None	-2	4	Human	8.5	pIC50	=	8.5	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	57514683	301	25	None	-2	4	Human	8.5	pIC50	=	8.5	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	91898441	301	25	None	-2	4	Human	8.5	pIC50	=	8.5	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	CHEMBL441738	301	25	None	-2	4	Human	8.5	pIC50	=	8.5	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	DB04931	301	25	None	-2	4	Human	8.5	pIC50	=	8.5	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	1324	301	25	None	-2	4	Human	8.5	pIC50	=	8.5	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm030111j
	16154396	301	25	None	-2	4	Human	8.5	pIC50	=	8.5	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm030111j
	16197727	301	25	None	-2	4	Human	8.5	pIC50	=	8.5	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm030111j
	44285019	301	25	None	-2	4	Human	8.5	pIC50	=	8.5	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm030111j
	57514683	301	25	None	-2	4	Human	8.5	pIC50	=	8.5	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm030111j
	91898441	301	25	None	-2	4	Human	8.5	pIC50	=	8.5	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm030111j
	CHEMBL441738	301	25	None	-2	4	Human	8.5	pIC50	=	8.5	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm030111j
	DB04931	301	25	None	-2	4	Human	8.5	pIC50	=	8.5	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm030111j
	CHEMBL266417	210660	0	None	-8	3	Human	8.5	pIC50	=	8.5	Binding	Inhibitory activity against human Melanocortin 3 receptorInhibitory activity against human Melanocortin 3 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm00018a005
	CHEMBL3600736	211789	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	1324	301	25	None	-2	4	Human	8.4	pIC50	=	8.4	Binding	Inhibitory activity against Melanocortin 3 receptorInhibitory activity against Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm00018a005
	16154396	301	25	None	-2	4	Human	8.4	pIC50	=	8.4	Binding	Inhibitory activity against Melanocortin 3 receptorInhibitory activity against Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm00018a005
	16197727	301	25	None	-2	4	Human	8.4	pIC50	=	8.4	Binding	Inhibitory activity against Melanocortin 3 receptorInhibitory activity against Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm00018a005
	44285019	301	25	None	-2	4	Human	8.4	pIC50	=	8.4	Binding	Inhibitory activity against Melanocortin 3 receptorInhibitory activity against Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm00018a005
	57514683	301	25	None	-2	4	Human	8.4	pIC50	=	8.4	Binding	Inhibitory activity against Melanocortin 3 receptorInhibitory activity against Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm00018a005
	91898441	301	25	None	-2	4	Human	8.4	pIC50	=	8.4	Binding	Inhibitory activity against Melanocortin 3 receptorInhibitory activity against Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm00018a005
	CHEMBL441738	301	25	None	-2	4	Human	8.4	pIC50	=	8.4	Binding	Inhibitory activity against Melanocortin 3 receptorInhibitory activity against Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm00018a005
	DB04931	301	25	None	-2	4	Human	8.4	pIC50	=	8.4	Binding	Inhibitory activity against Melanocortin 3 receptorInhibitory activity against Melanocortin 3 receptor	ChEMBL		None	None	None		None	10.1021/jm00018a005
	145964017	164017	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	915	11	12	9	0.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4208874	164017	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	915	11	12	9	0.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	16132144	209256	36	None	-30	4	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm049579s
	16133793	209256	36	None	-30	4	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm049579s
	44273719	209256	36	None	-30	4	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm049579s
	CHEMBL214332	209256	36	None	-30	4	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm049579s
	16132144	209256	36	None	-30	4	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm030111j
	16133793	209256	36	None	-30	4	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm030111j
	44273719	209256	36	None	-30	4	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm030111j
	CHEMBL214332	209256	36	None	-30	4	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm030111j
	CHEMBL408509	212697	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON	10.1021/jm049579s
	168295644	192288	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assay	ChEMBL	1106	17	13	12	1.5	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccccc2CSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	CHEMBL5206336	192288	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assay	ChEMBL	1106	17	13	12	1.5	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccccc2CSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	44348183	97136	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL	1493	31	14	21	-0.8	CC(=O)[C@@H]1CSSC[C@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	CHEMBL268094	97136	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL	1493	31	14	21	-0.8	CC(=O)[C@@H]1CSSC[C@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	44408173	75372	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	640	8	2	5	4.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2CCCS2(=O)=O)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	CHEMBL203975	75372	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	640	8	2	5	4.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2CCCS2(=O)=O)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	CHEMBL188738	209036	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O)C(C)=O	10.1021/jm0490033
	6918849	122938	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cells	ChEMBL	620	7	3	4	5.7	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2CCc3ccccc3[C@@H]2N)CC1	10.1016/j.bmcl.2005.05.012
	CHEMBL360818	122938	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cells	ChEMBL	620	7	3	4	5.7	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H]2CCc3ccccc3[C@@H]2N)CC1	10.1016/j.bmcl.2005.05.012
	163196518	192105	2	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assay	ChEMBL	1106	17	13	12	1.5	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2cccc(c2)CSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	CHEMBL5203580	192105	2	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assay	ChEMBL	1106	17	13	12	1.5	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2cccc(c2)CSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	24774519	94825	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	911	9	10	8	2.0	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)c2ccccc2C(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL253788	94825	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	911	9	10	8	2.0	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)c2ccccc2C(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL2310901	209475	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm049579s
	132938008	159489	0	None	-138	3	Mouse	5.5	pIC50	=	5.5	Binding	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL	948	11	10	10	-1.1	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	CHEMBL4102048	159489	0	None	-138	3	Mouse	5.5	pIC50	=	5.5	Binding	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL	948	11	10	10	-1.1	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	CHEMBL4299619	213572	0	None	-	0	Mouse	5.5	pIC50	=	5.5	Binding	Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisDisplacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	ChEMBL		None	None	None		CC(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@@H]1C(=O)NCC(=O)N1CCC[C@@H]1C(=O)NCC(=O)N1CCC[C@@H]1C(=O)NCC(=O)N1CCC[C@@H]1C(=O)NCC(=O)N1CCC[C@@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	54587278	60788	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	587	6	3	4	4.7	C[C@H]1CN(C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](C)N1	10.1016/j.bmcl.2011.02.090
	CHEMBL1762009	60788	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	587	6	3	4	4.7	C[C@H]1CN(C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](C)N1	10.1016/j.bmcl.2011.02.090
	CHEMBL3601426	211803	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	6918276	15579	7	None	-309	8	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
	CHEMBL1221512	15579	7	None	-309	8	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
	CHEMBL3349030	211382	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for Human Melanocortin 3 receptor expressed in L-cellsBinding affinity for Human Melanocortin 3 receptor expressed in L-cells	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	137653916	158556	0	None	-	1	Mouse	5.5	pIC50	=	5.5	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL	828	18	9	8	1.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4091894	158556	0	None	-	1	Mouse	5.5	pIC50	=	5.5	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL	828	18	9	8	1.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	127047475	139724	0	None	-	0	Mouse	5.5	pIC50	=	5.5	Binding	Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisDisplacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	ChEMBL	1630	54	21	19	-1.2	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	132991507	139724	0	None	-	0	Mouse	5.5	pIC50	=	5.5	Binding	Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisDisplacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	ChEMBL	1630	54	21	19	-1.2	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL3798421	139724	0	None	-	0	Mouse	5.5	pIC50	=	5.5	Binding	Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisDisplacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	ChEMBL	1630	54	21	19	-1.2	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	127047336	139773	0	None	-52	3	Mouse	6.5	pIC50	=	6.5	Binding	Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisDisplacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	ChEMBL	1730	54	21	19	1.1	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL3798768	139773	0	None	-52	3	Mouse	6.5	pIC50	=	6.5	Binding	Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisDisplacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	ChEMBL	1730	54	21	19	1.1	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	44418430	83226	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	334	4	0	2	3.1	O=C(Cc1ccccc1)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1	10.1016/j.bmcl.2006.07.015
	CHEMBL218748	83226	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	334	4	0	2	3.1	O=C(Cc1ccccc1)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1	10.1016/j.bmcl.2006.07.015
	10077258	14999	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	596	8	0	5	4.5	CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)S(C)(=O)=O	10.1016/j.bmcl.2010.06.038
	CHEMBL1209253	14999	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	596	8	0	5	4.5	CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)S(C)(=O)=O	10.1016/j.bmcl.2010.06.038
	3198	205490	76	None	-75	34	Human	4.4	pIC50	=	4.4	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL1201049	205490	76	None	-75	34	Human	4.4	pIC50	=	4.4	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL808	205490	76	None	-75	34	Human	4.4	pIC50	=	4.4	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL3600842	211796	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	24857886	155224	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	591	6	1	3	7.2	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(C(F)(F)F)cc2)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL402769	155224	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	591	6	1	3	7.2	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(C(F)(F)F)cc2)CC1	10.1016/j.bmcl.2008.04.049
	24858629	195446	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cellsDisplacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells	ChEMBL	853	10	9	10	1.0	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	CHEMBL552520	195446	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cellsDisplacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells	ChEMBL	853	10	9	10	1.0	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	44408155	140528	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	656	10	2	5	4.9	CC(C)N(CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)S(C)(=O)=O	10.1016/j.bmcl.2005.11.095
	CHEMBL381125	140528	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	656	10	2	5	4.9	CC(C)N(CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)S(C)(=O)=O	10.1016/j.bmcl.2005.11.095
	44445082	154278	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	799	9	10	8	0.2	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)CCCNCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL398664	154278	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	799	9	10	8	0.2	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)CCCNCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	54586246	60787	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	599	8	3	4	5.0	CC[C@@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](CC)N1	10.1016/j.bmcl.2011.02.090
	CHEMBL1762008	60787	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	599	8	3	4	5.0	CC[C@@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](CC)N1	10.1016/j.bmcl.2011.02.090
	CHEMBL2371967	210141	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]NDPalphaMSH from human cloned MC3R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC3R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2C(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2C1=O	10.1021/jm0614275
	CHEMBL190732	209044	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N(CCCCN)CC(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O)C(C)=O	10.1021/jm0490033
	CHEMBL2371835	210114	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCCN=C(N)N)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1021/jm0490033
	CHEMBL365794	212018	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N(CCCCN)CC(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O	10.1021/jm0490033
	1324	301	25	None	-	4	Mouse	8.4	pIC50	=	8.4	Binding	Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisDisplacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01894
	16154396	301	25	None	-	4	Mouse	8.4	pIC50	=	8.4	Binding	Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisDisplacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01894
	16197727	301	25	None	-	4	Mouse	8.4	pIC50	=	8.4	Binding	Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisDisplacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01894
	44285019	301	25	None	-	4	Mouse	8.4	pIC50	=	8.4	Binding	Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisDisplacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01894
	57514683	301	25	None	-	4	Mouse	8.4	pIC50	=	8.4	Binding	Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisDisplacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01894
	91898441	301	25	None	-	4	Mouse	8.4	pIC50	=	8.4	Binding	Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisDisplacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01894
	CHEMBL441738	301	25	None	-	4	Mouse	8.4	pIC50	=	8.4	Binding	Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisDisplacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01894
	DB04931	301	25	None	-	4	Mouse	8.4	pIC50	=	8.4	Binding	Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisDisplacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b01894
	145973779	164708	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	929	11	12	9	0.9	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4217528	164708	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	929	11	12	9	0.9	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	44577510	188711	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cellsDisplacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells	ChEMBL	893	12	11	11	0.4	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	CHEMBL504986	188711	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cellsDisplacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells	ChEMBL	893	12	11	11	0.4	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm701181n
	1334	1489	7	None	1	3	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	16133814	1489	7	None	1	3	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	CHEMBL437050	1489	7	None	1	3	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	CHEMBL1775066	208858	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by Wallac 1470 gamma countingDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by Wallac 1470 gamma counting	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1016/j.bmcl.2011.03.019
	44408388	140298	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	646	8	2	5	5.6	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2C(=O)OCC23CCC3)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	CHEMBL380635	140298	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	646	8	2	5	5.6	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2C(=O)OCC23CCC3)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	44277696	101178	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity towards human Melanocortin 3 receptor using radiolabeled NDP-MSH displacementBinding affinity towards human Melanocortin 3 receptor using radiolabeled NDP-MSH displacement	ChEMBL	770	22	10	8	-0.7	CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1016/j.bmcl.2005.08.012
	CHEMBL29582	101178	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity towards human Melanocortin 3 receptor using radiolabeled NDP-MSH displacementBinding affinity towards human Melanocortin 3 receptor using radiolabeled NDP-MSH displacement	ChEMBL	770	22	10	8	-0.7	CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1016/j.bmcl.2005.08.012
	44277696	101178	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity towards human melanocortin receptor hMC3R by using radioligand NDP-MSHBinding affinity towards human melanocortin receptor hMC3R by using radioligand NDP-MSH	ChEMBL	770	22	10	8	-0.7	CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1016/s0960-894x(02)00830-2
	CHEMBL29582	101178	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity towards human melanocortin receptor hMC3R by using radioligand NDP-MSHBinding affinity towards human melanocortin receptor hMC3R by using radioligand NDP-MSH	ChEMBL	770	22	10	8	-0.7	CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1016/s0960-894x(02)00830-2
	CHEMBL1161318	208482	0	None	-79	2	Human	7.4	pIC50	=	7.4	Binding	Binding affinity for human Melanocortin-3 receptorBinding affinity for human Melanocortin-3 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(CCCCC2)NC1=O	10.1021/jm0202526
	44397220	167280	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	582	7	2	4	4.7	CN1C[C@@H]2CC[C@H]1[C@@H](C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC1)C2	10.1016/j.bmcl.2005.05.109
	CHEMBL429387	167280	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	582	7	2	4	4.7	CN1C[C@@H]2CC[C@H]1[C@@H](C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC1)C2	10.1016/j.bmcl.2005.05.109
	CHEMBL3600841	211795	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	137649368	157382	0	None	-	1	Mouse	6.4	pIC50	=	6.4	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL	844	15	7	6	2.4	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4078495	157382	0	None	-	1	Mouse	6.4	pIC50	=	6.4	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL	844	15	7	6	2.4	CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	15953833	78945	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 3 receptorInhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 3 receptor	ChEMBL	622	9	2	6	6.6	COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccc(F)cc3)C2=O)cc1	10.1016/j.bmcl.2005.06.033
	CHEMBL2113037	78945	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 3 receptorInhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 3 receptor	ChEMBL	622	9	2	6	6.6	COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccc(F)cc3)C2=O)cc1	10.1016/j.bmcl.2005.06.033
	16725559	94960	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	591	6	1	3	7.5	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2008.04.049
	CHEMBL254757	94960	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	591	6	1	3	7.5	CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(C(=O)[C@H]2CN(C(C)(C)C)C[C@@H]2c2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2008.04.049
	44431513	145784	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]NDPalphaMSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDPalphaMSH from human MC3R expressed in HEK293 cells	ChEMBL	1054	14	12	10	1.4	CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N2Cc3ccccc3CC(NC1=O)C2=O	10.1016/j.bmcl.2007.02.020
	CHEMBL391704	145784	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]NDPalphaMSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDPalphaMSH from human MC3R expressed in HEK293 cells	ChEMBL	1054	14	12	10	1.4	CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N2Cc3ccccc3CC(NC1=O)C2=O	10.1016/j.bmcl.2007.02.020
	44348200	160172	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL	1511	33	16	22	-1.7	CC(=O)C1C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NC(C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)CSSC1(C)C	10.1021/jm030111j
	CHEMBL410949	160172	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL	1511	33	16	22	-1.7	CC(=O)C1C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NC(C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)CSSC1(C)C	10.1021/jm030111j
	CHEMBL3348530	211379	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibitory activity against human melanocortin 3 receptorInhibitory activity against human melanocortin 3 receptor	ChEMBL		None	None	None		CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1016/j.bmcl.2003.10.056
	132180599	156869	0	None	-	1	Mouse	6.4	pIC50	=	6.4	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4072129	156869	0	None	-	1	Mouse	6.4	pIC50	=	6.4	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL	841	20	11	7	0.2	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL2371965	210139	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]NDPalphaMSH from human cloned MC3R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC3R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H]2CC3CCCCC3N2C1=O	10.1021/jm0614275
	CHEMBL439691	213825	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON	10.1021/jm049579s
	168296790	192322	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assay	ChEMBL	1163	17	13	12	3.0	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(N)=O)C(C)(C)SCc2cccc(c2)CSC1(C)C	10.1021/acs.jmedchem.1c01848
	CHEMBL5206941	192322	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assay	ChEMBL	1163	17	13	12	3.0	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(N)=O)C(C)(C)SCc2cccc(c2)CSC1(C)C	10.1021/acs.jmedchem.1c01848
	168273291	190508	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assay	ChEMBL	1163	17	13	12	3.0	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(N)=O)C(C)(C)SCc2ccccc2CSC1(C)C	10.1021/acs.jmedchem.1c01848
	CHEMBL5179637	190508	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assay	ChEMBL	1163	17	13	12	3.0	CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(N)=O)C(C)(C)SCc2ccccc2CSC1(C)C	10.1021/acs.jmedchem.1c01848
	145987870	167210	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting analysisDisplacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting analysis	ChEMBL	620	14	5	5	2.2	CCCC[C@H](NC(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	CHEMBL4292317	167210	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting analysisDisplacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting analysis	ChEMBL	620	14	5	5	2.2	CCCC[C@H](NC(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	44408190	96894	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	606	8	2	5	4.7	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2CCOC2=O)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	CHEMBL265985	96894	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	606	8	2	5	4.7	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2CCOC2=O)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	CHEMBL3600833	211791	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3349030	211382	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity for Human Melanocortin 3 receptor expressed in L-cellsBinding affinity for Human Melanocortin 3 receptor expressed in L-cells	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	49862378	15010	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	534	8	0	4	4.6	CC(=O)N(CC(CC(C)C)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(C)C	10.1016/j.bmcl.2010.06.038
	CHEMBL1209321	15010	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	534	8	0	4	4.6	CC(=O)N(CC(CC(C)C)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(C)C	10.1016/j.bmcl.2010.06.038
	71459938	78952	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 3 receptorInhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 3 receptor	ChEMBL	622	9	2	6	6.6	COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@H]3CCNC[C@@H]3c3ccc(F)cc3)C2=O)cc1	10.1016/j.bmcl.2005.06.033
	CHEMBL2113043	78952	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 3 receptorInhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 3 receptor	ChEMBL	622	9	2	6	6.6	COc1ccc(N2N=C(Sc3ccc(Cl)cc3)CC(CC[C@@H](C)NC(=O)[C@H]3CCNC[C@@H]3c3ccc(F)cc3)C2=O)cc1	10.1016/j.bmcl.2005.06.033
	44397455	123817	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cells	ChEMBL	620	7	3	4	5.2	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2Cc3ccccc3CC2N)CC1	10.1016/j.bmcl.2005.05.012
	CHEMBL362523	123817	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cells	ChEMBL	620	7	3	4	5.2	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2Cc3ccccc3CC2N)CC1	10.1016/j.bmcl.2005.05.012
	CHEMBL417853	213215	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Inhibitory activity against hMC3R (human melanocortin receptor) using [125I]-[Nle4] alpha-MSH as radioligandInhibitory activity against hMC3R (human melanocortin receptor) using [125I]-[Nle4] alpha-MSH as radioligand	ChEMBL		None	None	None		C[C@H](c1ccccc1)N(CC(N)=O)C(=O)CN(C(=O)CNCCCN=C(N)N)C(c1ccccc1)c1ccccc1	10.1016/s0960-894x(03)00164-1
	46919520	15106	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of human melanocortin 3 receptorInhibition of human melanocortin 3 receptor	ChEMBL	597	4	0	5	6.3	Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N	10.1016/j.bmcl.2010.06.068
	CHEMBL1209788	15106	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of human melanocortin 3 receptorInhibition of human melanocortin 3 receptor	ChEMBL	597	4	0	5	6.3	Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N	10.1016/j.bmcl.2010.06.068
	44408276	75478	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	632	8	2	5	5.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2C(=O)OCC23CC3)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	CHEMBL204308	75478	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	632	8	2	5	5.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2C(=O)OCC23CC3)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	49862425	15028	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	570	9	0	5	4.0	CC(C)CC(CN(C(C)C)S(C)(=O)=O)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1	10.1016/j.bmcl.2010.06.038
	CHEMBL1209382	15028	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	570	9	0	5	4.0	CC(C)CC(CN(C(C)C)S(C)(=O)=O)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1	10.1016/j.bmcl.2010.06.038
	155551202	173935	0	None	-	0	Mouse	4.3	pIC50	=	4.3	Binding	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL	895	8	8	10	-0.5	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CS)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	CHEMBL4541505	173935	0	None	-	0	Mouse	4.3	pIC50	=	4.3	Binding	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL	895	8	8	10	-0.5	C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CS)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	44418431	136531	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	334	4	0	2	3.1	O=C(Cc1ccccc1)N1C[C@@H]2CCCN2C[C@H]1Cc1ccccc1	10.1016/j.bmcl.2006.07.015
	CHEMBL373821	136531	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	334	4	0	2	3.1	O=C(Cc1ccccc1)N1C[C@@H]2CCCN2C[C@H]1Cc1ccccc1	10.1016/j.bmcl.2006.07.015
	CHEMBL413439	213047	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm049579s
	145966716	164281	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	887	11	12	9	-0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4212209	164281	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	887	11	12	9	-0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCC2)NC(=O)C[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	1324	301	25	None	-	4	Mouse	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00301
	16154396	301	25	None	-	4	Mouse	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00301
	16197727	301	25	None	-	4	Mouse	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00301
	44285019	301	25	None	-	4	Mouse	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00301
	57514683	301	25	None	-	4	Mouse	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00301
	91898441	301	25	None	-	4	Mouse	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00301
	CHEMBL441738	301	25	None	-	4	Mouse	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00301
	DB04931	301	25	None	-	4	Mouse	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.7b00301
	44431511	88037	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]NDPalphaMSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDPalphaMSH from human MC3R expressed in HEK293 cells	ChEMBL	1004	14	12	10	0.3	CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)N2Cc3ccccc3CC(NC1=O)C2=O	10.1016/j.bmcl.2007.02.020
	CHEMBL234629	88037	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]NDPalphaMSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDPalphaMSH from human MC3R expressed in HEK293 cells	ChEMBL	1004	14	12	10	0.3	CCCC[C@H](N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)N2Cc3ccccc3CC(NC1=O)C2=O	10.1016/j.bmcl.2007.02.020
	CHEMBL263948	210576	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]NDP-MSH from Melanocortin 3 receptor at 10 uMDisplacement of [125I]NDP-MSH from Melanocortin 3 receptor at 10 uM	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm960840h
	16132144	209256	36	None	-30	4	Human	7.3	pIC50	=	7.3	Binding	Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm960845e
	16133793	209256	36	None	-30	4	Human	7.3	pIC50	=	7.3	Binding	Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm960845e
	44273719	209256	36	None	-30	4	Human	7.3	pIC50	=	7.3	Binding	Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm960845e
	CHEMBL214332	209256	36	None	-30	4	Human	7.3	pIC50	=	7.3	Binding	Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm960845e
	CHEMBL1775062	208857	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by Wallac 1470 gamma countingDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by Wallac 1470 gamma counting	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1016/j.bmcl.2011.03.019
	118735100	118774	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells by gamma counting analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells by gamma counting analysis	ChEMBL	764	15	9	6	1.8	CC(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN([C@H](Cc2ccc(F)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	CHEMBL3421677	118774	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells by gamma counting analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells by gamma counting analysis	ChEMBL	764	15	9	6	1.8	CC(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN([C@H](Cc2ccc(F)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O	10.1021/ml500436s
	CHEMBL191120	209057	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N(CC(=O)NCC(N)=O)Cc1c[nH]c2ccccc12	10.1021/jm0490033
	CHEMBL191063	209056	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N(CC(=O)NCC(N)=O)Cc1c[nH]c2ccccc12	10.1021/jm0490033
	CHEMBL370321	212144	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1021/jm0490033
	CHEMBL264190	210585	1	None	-39	2	Mouse	4.3	pIC50	=	4.3	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL3600921	211801	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	44408252	140644	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	605	8	3	4	4.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2CCNC2=O)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	CHEMBL381503	140644	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	605	8	3	4	4.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(CN2CCNC2=O)(C2CCCCC2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.11.095
	155548853	173785	0	None	-79	4	Mouse	4.3	pIC50	=	4.3	Binding	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL	1005	13	10	10	-0.6	CC(C)[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	CHEMBL4538274	173785	0	None	-79	4	Mouse	4.3	pIC50	=	4.3	Binding	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL	1005	13	10	10	-0.6	CC(C)[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.9b00860
	137653704	158609	0	None	-	1	Mouse	5.3	pIC50	=	5.3	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL	838	18	8	7	2.2	CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4092424	158609	0	None	-	1	Mouse	5.3	pIC50	=	5.3	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL	838	18	8	7	2.2	CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL3600913	211799	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	145971389	164609	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	851	11	12	9	-1.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4216242	164609	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	851	11	12	9	-1.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	132180598	157825	0	None	-	1	Mouse	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL	803	17	10	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4083717	157825	0	None	-	1	Mouse	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL	803	17	10	7	-0.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL446185	213921	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibitory activity against hMC3R transfected in HEK293 cellsInhibitory activity against hMC3R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm0510326
	71449048	78452	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL	1483	33	16	22	-2.5	CC(=O)[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	CHEMBL2111808	78452	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL	1483	33	16	22	-2.5	CC(=O)[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	145966490	164338	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	839	11	12	9	-1.2	CC1(C)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4212762	164338	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	839	11	12	9	-1.2	CC1(C)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.8b00488
	145948912	167461	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysisDisplacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysis	ChEMBL	1170	17	14	11	0.7	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.5b01285
	CHEMBL4299454	167461	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysisDisplacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysis	ChEMBL	1170	17	14	11	0.7	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.5b01285
	122184914	122533	0	None	-	1	Human	5.2	pIC50	=	5.2	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1144	17	9	11	1.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3601432	122533	0	None	-	1	Human	5.2	pIC50	=	5.2	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1144	17	9	11	1.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	145966364	164096	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	865	11	12	9	-0.7	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4209913	164096	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	865	11	12	9	-0.7	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL3754655	212200	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysisDisplacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysis	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C1=O	10.1021/acs.jmedchem.5b01285
	CHEMBL414778	213133	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON	10.1021/jm049579s
	CHEMBL438920	213786	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)ON	10.1021/jm049579s
	CHEMBL204864	209143	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibitory activity against hMC3R transfected in HEK293 cellsInhibitory activity against hMC3R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCC)NC1=O	10.1021/jm0510326
	16157270	212530	14	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity for Human Melanocortin 3 receptor expressed in L-cellsBinding affinity for Human Melanocortin 3 receptor expressed in L-cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	CHEMBL405282	212530	14	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity for Human Melanocortin 3 receptor expressed in L-cellsBinding affinity for Human Melanocortin 3 receptor expressed in L-cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	CHEMBL2372589	210250	0	None	15	2	Human	8.2	pIC50	=	8.2	Binding	Binding affinity for human Melanocortin-3 receptorBinding affinity for human Melanocortin-3 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2Cc3ccccc3CN2C1=O	10.1021/jm0202526
	16157270	212530	14	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm049579s
	CHEMBL405282	212530	14	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm049579s
	CHEMBL427205	213329	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibitory activity against hMC3R transfected in HEK293 cellsInhibitory activity against hMC3R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)NC1=O	10.1021/jm0510326
	122184912	122532	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3601430	122532	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1130	17	10	11	1.5	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3349030	211382	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Binding affinity for Human Melanocortin 3 receptor expressed in L-cellsBinding affinity for Human Melanocortin 3 receptor expressed in L-cells	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	44577520	188800	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cellsDisplacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells	ChEMBL	904	12	10	11	1.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O	10.1021/jm701181n
	CHEMBL506274	188800	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cellsDisplacement of [125I]-[Nle4, D-Phe7]alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells	ChEMBL	904	12	10	11	1.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2cc([N+](=O)[O-])ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O	10.1021/jm701181n
	CHEMBL411359	212856	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm049579s
	44396987	67163	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	568	7	3	4	4.3	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H]2C[C@@H]3CC[C@@H]2NC3)CC1	10.1016/j.bmcl.2005.05.109
	CHEMBL187774	67163	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	568	7	3	4	4.3	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H]2C[C@@H]3CC[C@@H]2NC3)CC1	10.1016/j.bmcl.2005.05.109
	71452720	78942	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	568	7	3	4	4.3	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2C[C@H]3CC[C@@H]2NC3)CC1	10.1016/j.bmcl.2005.05.109
	CHEMBL2113031	78942	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	568	7	3	4	4.3	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H]2C[C@H]3CC[C@@H]2NC3)CC1	10.1016/j.bmcl.2005.05.109
	71456220	78719	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL	1483	33	16	22	-2.5	CC(=O)[C@H]1CSSC[C@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	CHEMBL2112604	78719	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human Melanocortin 3 receptorInhibition of human Melanocortin 3 receptor	ChEMBL	1483	33	16	22	-2.5	CC(=O)[C@H]1CSSC[C@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	CHEMBL264190	210585	1	None	-	2	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting analysisDisplacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting analysis	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	44408253	140319	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	650	10	2	5	6.1	CCOC(=O)N(CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)C(C)C	10.1016/j.bmcl.2005.11.095
	CHEMBL380727	140319	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	650	10	2	5	6.1	CCOC(=O)N(CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1)C(C)C	10.1016/j.bmcl.2005.11.095
	CHEMBL2371963	210137	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]NDPalphaMSH from human cloned MC3R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC3R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/jm0614275
	CHEMBL190080	209039	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCCN=C(N)N)CC(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O	10.1021/jm0490033
	168295131	192218	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assay	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccc(cc2)CSC(C)(C)[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	CHEMBL5205283	192218	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assay	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccc(cc2)CSC(C)(C)[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	CHEMBL3600843	211797	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	52918026	60778	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	571	6	3	4	4.2	C[C@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](C)N1	10.1016/j.bmcl.2011.02.090
	CHEMBL1761870	60778	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	571	6	3	4	4.2	C[C@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](C)N1	10.1016/j.bmcl.2011.02.090
	137658359	159547	0	None	-	1	Mouse	5.2	pIC50	=	5.2	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL	791	20	11	7	-1.0	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4102774	159547	0	None	-	1	Mouse	5.2	pIC50	=	5.2	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL	791	20	11	7	-1.0	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/acs.jmedchem.7b00301
	10257242	14998	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	560	7	0	4	5.1	CC(=O)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(C)C	10.1016/j.bmcl.2010.06.038
	CHEMBL1209252	14998	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	560	7	0	4	5.1	CC(=O)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(C)C	10.1016/j.bmcl.2010.06.038
	CHEMBL3601431	211804	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	44408189	168855	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	619	8	2	4	4.6	CN1CCN(CC2(C3CCCCC3)CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)C1=O	10.1016/j.bmcl.2005.11.095
	CHEMBL438259	168855	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	619	8	2	4	4.6	CN1CCN(CC2(C3CCCCC3)CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)C1=O	10.1016/j.bmcl.2005.11.095
	168278924	191042	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assay	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2cccc(c2)CSC(C)(C)[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	CHEMBL5187368	191042	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assay	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2cccc(c2)CSC(C)(C)[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	1334	1489	7	None	1	3	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	16133814	1489	7	None	1	3	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	CHEMBL437050	1489	7	None	1	3	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)	ChEMBL		None	None	None		None	10.1021/jm049579s
	1334	1489	7	None	1	3	Human	7.1	pIC50	=	7.1	Binding	Binding affinity for Human Melanocortin 3 receptor expressed in L-cellsBinding affinity for Human Melanocortin 3 receptor expressed in L-cells	ChEMBL		None	None	None		None	10.1021/jm000211e
	16133814	1489	7	None	1	3	Human	7.1	pIC50	=	7.1	Binding	Binding affinity for Human Melanocortin 3 receptor expressed in L-cellsBinding affinity for Human Melanocortin 3 receptor expressed in L-cells	ChEMBL		None	None	None		None	10.1021/jm000211e
	CHEMBL437050	1489	7	None	1	3	Human	7.1	pIC50	=	7.1	Binding	Binding affinity for Human Melanocortin 3 receptor expressed in L-cellsBinding affinity for Human Melanocortin 3 receptor expressed in L-cells	ChEMBL		None	None	None		None	10.1021/jm000211e
	CHEMBL3349030	211382	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity for Human Melanocortin 3 receptor expressed in L-cellsBinding affinity for Human Melanocortin 3 receptor expressed in L-cells	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	145976863	163734	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	879	11	12	9	-0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	CHEMBL4205548	163734	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	ChEMBL	879	11	12	9	-0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)C2(CCCCC2)NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/acs.jmedchem.8b00488
	168274393	190081	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assay	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccccc2CSC(C)(C)[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	CHEMBL5172938	190081	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assay	ChEMBL	1135	17	13	12	2.2	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CSCc2ccccc2CSC(C)(C)[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c01848
	54584302	60782	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	571	6	3	4	4.2	C[C@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@H](C)N1	10.1016/j.bmcl.2011.02.090
	CHEMBL1761874	60782	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	571	6	3	4	4.2	C[C@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@H](C)N1	10.1016/j.bmcl.2011.02.090
	54584301	60780	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	585	6	2	4	4.6	C[C@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](C)N1C	10.1016/j.bmcl.2011.02.090
	CHEMBL1761872	60780	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	585	6	2	4	4.6	C[C@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](C)N1C	10.1016/j.bmcl.2011.02.090
	44408154	141337	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	668	8	2	5	5.1	CC1(C)CCN(CC2(C3CCCCC3)CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)S1(=O)=O	10.1016/j.bmcl.2005.11.095
	CHEMBL383719	141337	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	668	8	2	5	5.1	CC1(C)CCN(CC2(C3CCCCC3)CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@H]3Cc4ccccc4CN3)CC2)S1(=O)=O	10.1016/j.bmcl.2005.11.095
	1338	3778	43	None	-75	4	Human	6.1	pIC50	=	6.1	Binding	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2005.05.012
	9938402	3778	43	None	-75	4	Human	6.1	pIC50	=	6.1	Binding	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2005.05.012
	CHEMBL339053	3778	43	None	-75	4	Human	6.1	pIC50	=	6.1	Binding	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2005.05.012
	1338	3778	43	None	-75	4	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2005.11.095
	9938402	3778	43	None	-75	4	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2005.11.095
	CHEMBL339053	3778	43	None	-75	4	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2005.11.095
	1338	3778	43	None	-75	4	Human	6.1	pIC50	=	6.1	Binding	Evaluated for binding affinity against human Melanocortin-3 receptor (hMC3R) by displacing [125I]NDP-alpha-MSH radioligand expressed in CHO cellsEvaluated for binding affinity against human Melanocortin-3 receptor (hMC3R) by displacing [125I]NDP-alpha-MSH radioligand expressed in CHO cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	9938402	3778	43	None	-75	4	Human	6.1	pIC50	=	6.1	Binding	Evaluated for binding affinity against human Melanocortin-3 receptor (hMC3R) by displacing [125I]NDP-alpha-MSH radioligand expressed in CHO cellsEvaluated for binding affinity against human Melanocortin-3 receptor (hMC3R) by displacing [125I]NDP-alpha-MSH radioligand expressed in CHO cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	CHEMBL339053	3778	43	None	-75	4	Human	6.1	pIC50	=	6.1	Binding	Evaluated for binding affinity against human Melanocortin-3 receptor (hMC3R) by displacing [125I]NDP-alpha-MSH radioligand expressed in CHO cellsEvaluated for binding affinity against human Melanocortin-3 receptor (hMC3R) by displacing [125I]NDP-alpha-MSH radioligand expressed in CHO cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm025539h
	49862375	15007	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	624	8	0	6	5.2	CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(=O)c1cccnn1	10.1016/j.bmcl.2010.06.038
	CHEMBL1209318	15007	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	624	8	0	6	5.2	CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(=O)c1cccnn1	10.1016/j.bmcl.2010.06.038
	CHEMBL190953	209054	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N(CCCCN)CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N(CC(=O)NCC(N)=O)Cc1c[nH]c2ccccc12	10.1021/jm0490033
	CHEMBL275999	210803	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCCN(CC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CCCN=C(N)N)CC(=O)N(CC(=O)NCC(N)=O)Cc1c[nH]c2ccccc12)C(C)=O	10.1021/jm0490033
	CHEMBL372237	212149	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cellsDisplacement of [125I]NDP-MSH from human melanocortin receptor-3 expressed in 293 HEK cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N(CCc1c[nH]c2ccccc12)CC(=O)NCC(N)=O	10.1021/jm0490033
	122184577	122403	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600838	122403	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1102	17	12	11	0.8	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	1323	2669	55	None	-72	3	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by Wallac 1470 gamma countingDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by Wallac 1470 gamma counting	ChEMBL		None	None	None		None	10.1016/j.bmcl.2011.03.019
	92432	2669	55	None	-72	3	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by Wallac 1470 gamma countingDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by Wallac 1470 gamma counting	ChEMBL		None	None	None		None	10.1016/j.bmcl.2011.03.019
	CHEMBL430239	2669	55	None	-72	3	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by Wallac 1470 gamma countingDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by Wallac 1470 gamma counting	ChEMBL		None	None	None		None	10.1016/j.bmcl.2011.03.019
	122184636	122409	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600917	122409	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	1324	301	25	None	-	4	Mouse	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	16154396	301	25	None	-	4	Mouse	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	16197727	301	25	None	-	4	Mouse	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	44285019	301	25	None	-	4	Mouse	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	57514683	301	25	None	-	4	Mouse	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	91898441	301	25	None	-	4	Mouse	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	CHEMBL441738	301	25	None	-	4	Mouse	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	DB04931	301	25	None	-	4	Mouse	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting methodDisplacement of [125I]-NDP-MSH from mouse melanocortin receptor 3 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b00860
	1323	2669	55	None	-72	3	Human	8.1	pIC50	=	8.1	Binding	Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		None	10.1021/jm960845e
	92432	2669	55	None	-72	3	Human	8.1	pIC50	=	8.1	Binding	Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		None	10.1021/jm960845e
	CHEMBL430239	2669	55	None	-72	3	Human	8.1	pIC50	=	8.1	Binding	Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)Inhibitory concentration against human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		None	10.1021/jm960845e
	CHEMBL3349030	211382	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity for Human Melanocortin 3 receptor expressed in L-cellsBinding affinity for Human Melanocortin 3 receptor expressed in L-cells	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1021/jm000211e
	CHEMBL409144	212724	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibitory activity against hMC3R transfected in HEK293 cellsInhibitory activity against hMC3R transfected in HEK293 cells	ChEMBL		None	None	None		CCCC[C@@H]1NC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](CC(=O)O)NC1=O	10.1021/jm0510326
	10210964	67213	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cells	ChEMBL	606	7	3	4	5.3	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2Cc3ccccc3C2N)CC1	10.1016/j.bmcl.2005.05.012
	CHEMBL187990	67213	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cells	ChEMBL	606	7	3	4	5.3	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2Cc3ccccc3C2N)CC1	10.1016/j.bmcl.2005.05.012
	44445084	160715	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	829	9	11	9	0.2	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](N)CCCCC(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	CHEMBL411391	160715	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	829	9	11	9	0.2	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](N)CCCCC(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	44408275	75390	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	620	8	2	5	5.1	C[C@H]1COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.11.095
	CHEMBL204078	75390	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	620	8	2	5	5.1	C[C@H]1COC(=O)N1CC1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.11.095
	CHEMBL3799094	212245	0	None	-	0	Mouse	5.1	pIC50	=	5.1	Binding	Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisDisplacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	ChEMBL		None	None	None		N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL375947	212209	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]NDPalphaMSH from human cloned MC3R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC3R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	49862377	15009	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	654	9	0	6	6.2	CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(=O)c1cnn(C(C)C)c1	10.1016/j.bmcl.2010.06.038
	CHEMBL1209320	15009	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	654	9	0	6	6.2	CC(C)N(CC(C1CCCCC1)N1CCN(C(=O)[C@@H]2CN(C(C)(C)C)C[C@H]2c2ccc(F)cc2F)CC1)C(=O)c1cnn(C(C)C)c1	10.1016/j.bmcl.2010.06.038
	11753695	8361	7	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	599	4	1	3	6.7	CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21	10.1016/j.bmcl.2010.02.058
	CHEMBL1093304	8361	7	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cells	ChEMBL	599	4	1	3	6.7	CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)c2cc(Cl)c(C)cc21	10.1016/j.bmcl.2010.02.058
	122184633	122406	0	None	-	1	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL3600914	122406	0	None	-	1	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL	1116	17	11	11	1.1	CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.5b00102
	1323	2669	55	None	-72	3	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01848
	92432	2669	55	None	-72	3	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01848
	CHEMBL430239	2669	55	None	-72	3	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assayDisplacement of [125I]NDP-alpha-MSH from human MC3R expressed in HEK293 cells by competitive binding assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c01848
	145990599	166831	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting analysisDisplacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting analysis	ChEMBL	710	17	7	6	2.6	CCCC[C@H](NC(=O)[C@@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	CHEMBL4285535	166831	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting analysisDisplacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting analysis	ChEMBL	710	17	7	6	2.6	CCCC[C@H](NC(=O)[C@@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/j.ejmech.2018.04.021
	44397410	124333	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 3 receptor expressed in CHO cellsInhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 3 receptor expressed in CHO cells	ChEMBL	620	10	2	7	6.0	COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccc(F)cc3)c2=O)cc1	10.1016/j.bmcl.2005.06.033
	CHEMBL363740	124333	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 3 receptor expressed in CHO cellsInhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 3 receptor expressed in CHO cells	ChEMBL	620	10	2	7	6.0	COc1ccc(-n2nc(Sc3ccc(Cl)cc3)cc(CC[C@@H](C)NC(=O)[C@H]3CNCC[C@@H]3c3ccc(F)cc3)c2=O)cc1	10.1016/j.bmcl.2005.06.033
	1337	3398	6	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	582	7	2	4	4.7	O=C([C@@H]1C[C@@H]2CC[C@H]1N(C2)C)N[C@@H](C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C)Cc1ccc(cc1)F	10.1016/j.bmcl.2005.05.109
	6918851	3398	6	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	582	7	2	4	4.7	O=C([C@@H]1C[C@@H]2CC[C@H]1N(C2)C)N[C@@H](C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C)Cc1ccc(cc1)F	10.1016/j.bmcl.2005.05.109
	CHEMBL364346	3398	6	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cellsInhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells	ChEMBL	582	7	2	4	4.7	O=C([C@@H]1C[C@@H]2CC[C@H]1N(C2)C)N[C@@H](C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C)Cc1ccc(cc1)F	10.1016/j.bmcl.2005.05.109
	137639815	156778	0	None	-	1	Mouse	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL	847	20	11	8	0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4071063	156778	0	None	-	1	Mouse	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL	847	20	11	8	0.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O	10.1021/acs.jmedchem.7b00301
	10304776	78950	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cells	ChEMBL	634	7	3	4	6.1	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2CCCc3ccccc3C2N)CC1	10.1016/j.bmcl.2005.05.012
	CHEMBL2113041	78950	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cellsConcentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC3R expressed in CHO cells	ChEMBL	634	7	3	4	6.1	CC(C)(C)NC(=O)C1(C2CCCCC2)CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2CCCc3ccccc3C2N)CC1	10.1016/j.bmcl.2005.05.012
	10483153	60781	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	571	6	3	4	4.2	C[C@@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](C)N1	10.1016/j.bmcl.2011.02.090
	CHEMBL1761873	60781	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cells	ChEMBL	571	6	3	4	4.2	C[C@@H]1CN(C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)N2CCC(C(=O)NC(C)(C)C)(C3CCCCC3)CC2)C[C@@H](C)N1	10.1016/j.bmcl.2011.02.090
	132180597	156147	0	None	-	1	Mouse	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL	784	15	8	7	-0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL4063911	156147	0	None	-	1	Mouse	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma countingDisplacement of [125I]-NDP-MSH from mouse MC3R expressed in HEK293 cells after 1 hr by gamma counting	ChEMBL	784	15	8	7	-0.0	CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O	10.1021/acs.jmedchem.7b00301
	CHEMBL3600922	211802	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence countingDisplacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)[C@H](Cc2cnc[nH]2)N(C)C1=O	10.1021/acs.jmedchem.5b00102
	CHEMBL389674	212410	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [125I]NDPalphaMSH from human cloned MC3R expressed in CHO cellsDisplacement of [125I]NDPalphaMSH from human cloned MC3R expressed in CHO cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/jm0614275
	127046262	139795	0	None	-79	3	Mouse	6.0	pIC50	=	6	Binding	Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisDisplacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	ChEMBL	1012	35	12	13	-0.3	N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)COCC(=O)NCCCOCCOCCOCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	CHEMBL3798912	139795	0	None	-79	3	Mouse	6.0	pIC50	=	6	Binding	Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisDisplacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysis	ChEMBL	1012	35	12	13	-0.3	N=C(N)NCCC[C@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)COCC(=O)NCCCOCCOCCOCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/acs.jmedchem.5b01894
	1325	3573	14	None	-12	7	Mouse	9.5	pKd	=	9.5	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b00184
	6440621	3573	14	None	-12	7	Mouse	9.5	pKd	=	9.5	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b00184
	9898183	3573	14	None	-12	7	Mouse	9.5	pKd	=	9.5	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b00184
	CHEMBL3422426	3573	14	None	-12	7	Mouse	9.5	pKd	=	9.5	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.5b00184
	44366081	10230	0	None	-2	2	Human	9.4	pKd	=	9.4	Binding	pA2 value for human Melanocortin-3 receptorpA2 value for human Melanocortin-3 receptor	ChEMBL	1036	15	13	11	0.4	CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(O)[C@H]2CCCN2C1=O	10.1021/jm0202526
	CHEMBL1161313	10230	0	None	-2	2	Human	9.4	pKd	=	9.4	Binding	pA2 value for human Melanocortin-3 receptorpA2 value for human Melanocortin-3 receptor	ChEMBL	1036	15	13	11	0.4	CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(O)[C@H]2CCCN2C1=O	10.1021/jm0202526
	CHEMBL2372589	210250	0	None	15	2	Human	9.2	pKd	=	9.2	Binding	pA2 value for human Melanocortin-3 receptorpA2 value for human Melanocortin-3 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2Cc3ccccc3CN2C1=O	10.1021/jm0202526
	CHEMBL1161322	208485	0	None	-1	2	Human	9.0	pKd	=	9	Binding	pA2 value for human Melanocortin-3 receptorpA2 value for human Melanocortin-3 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2CCCN2C1=O	10.1021/jm0202526
	1325	3573	14	None	-12	7	Mouse	8.7	pKd	=	8.7	Binding	Competitive antagonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells assessed as inhibition of MTII-induced response after 6 hrs by Schild analysisCompetitive antagonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells assessed as inhibition of MTII-induced response after 6 hrs by Schild analysis	ChEMBL		None	None	None		None	10.1021/ml500340z
	6440621	3573	14	None	-12	7	Mouse	8.7	pKd	=	8.7	Binding	Competitive antagonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells assessed as inhibition of MTII-induced response after 6 hrs by Schild analysisCompetitive antagonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells assessed as inhibition of MTII-induced response after 6 hrs by Schild analysis	ChEMBL		None	None	None		None	10.1021/ml500340z
	9898183	3573	14	None	-12	7	Mouse	8.7	pKd	=	8.7	Binding	Competitive antagonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells assessed as inhibition of MTII-induced response after 6 hrs by Schild analysisCompetitive antagonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells assessed as inhibition of MTII-induced response after 6 hrs by Schild analysis	ChEMBL		None	None	None		None	10.1021/ml500340z
	CHEMBL3422426	3573	14	None	-12	7	Mouse	8.7	pKd	=	8.7	Binding	Competitive antagonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells assessed as inhibition of MTII-induced response after 6 hrs by Schild analysisCompetitive antagonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells assessed as inhibition of MTII-induced response after 6 hrs by Schild analysis	ChEMBL		None	None	None		None	10.1021/ml500340z
	CHEMBL2096742	209183	0	None	-5	2	Human	8.7	pKd	=	8.7	Binding	pA2 value for human melanocortin receptor Melanocortin-3 receptorpA2 value for human melanocortin receptor Melanocortin-3 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm0202526
	122178168	121235	0	None	-25	2	Mouse	7.0	pKd	=	7	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL	963	12	10	10	-0.7	C[C@@H]1NC(=O)C(CCN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	CHEMBL3577997	121235	0	None	-25	2	Mouse	7.0	pKd	=	7	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL	963	12	10	10	-0.7	C[C@@H]1NC(=O)C(CCN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	CHEMBL3577999	211730	0	None	-19	2	Mouse	7.0	pKd	=	7	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	122178158	121227	0	None	-10	2	Mouse	6.0	pKd	=	6	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL	1027	12	10	10	-0.1	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)C(Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	CHEMBL3577987	121227	0	None	-10	2	Mouse	6.0	pKd	=	6	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL	1027	12	10	10	-0.1	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)C(Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	122178167	121234	0	None	-162	2	Mouse	6.9	pKd	=	6.9	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL	948	11	10	10	-1.1	C[C@@H]1NC(=O)C(CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	CHEMBL3577996	121234	0	None	-162	2	Mouse	6.9	pKd	=	6.9	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL	948	11	10	10	-1.1	C[C@@H]1NC(=O)C(CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	118735609	118854	0	None	-251	2	Mouse	5.9	pKd	=	5.9	Binding	Antagonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells assessed as inhibition of MTII-induced response after 6 hrs by Schild analysisAntagonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells assessed as inhibition of MTII-induced response after 6 hrs by Schild analysis	ChEMBL	871	18	9	6	2.7	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/ml500340z
	CHEMBL3422432	118854	0	None	-251	2	Mouse	5.9	pKd	=	5.9	Binding	Antagonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells assessed as inhibition of MTII-induced response after 6 hrs by Schild analysisAntagonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells assessed as inhibition of MTII-induced response after 6 hrs by Schild analysis	ChEMBL	871	18	9	6	2.7	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/ml500340z
	CHEMBL3577980	211725	0	None	-7	2	Mouse	5.9	pKd	=	5.9	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	122178169	121236	0	None	-31	2	Mouse	6.8	pKd	=	6.8	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL	977	13	10	10	-0.4	C[C@@H]1NC(=O)C(CCCN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	CHEMBL3577998	121236	0	None	-31	2	Mouse	6.8	pKd	=	6.8	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL	977	13	10	10	-0.4	C[C@@H]1NC(=O)C(CCCN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	CHEMBL3578000	211731	0	None	-50	2	Mouse	6.7	pKd	=	6.7	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CCCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	118735610	118855	0	None	-398	2	Mouse	5.7	pKd	=	5.7	Binding	Antagonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells assessed as inhibition of MTII-induced response after 6 hrs by Schild analysisAntagonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells assessed as inhibition of MTII-induced response after 6 hrs by Schild analysis	ChEMBL	871	18	9	6	2.7	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/ml500340z
	CHEMBL3422433	118855	0	None	-398	2	Mouse	5.7	pKd	=	5.7	Binding	Antagonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells assessed as inhibition of MTII-induced response after 6 hrs by Schild analysisAntagonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells assessed as inhibition of MTII-induced response after 6 hrs by Schild analysis	ChEMBL	871	18	9	6	2.7	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O	10.1021/ml500340z
	CHEMBL3577995	211729	0	None	-6	2	Mouse	7.6	pKd	=	7.6	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		C[C@@H]1NC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	CHEMBL1161320	208483	0	None	12	2	Human	7.6	pKd	=	7.6	Binding	pA2 value for human melanocortin receptor Melanocortin-3 receptorpA2 value for human melanocortin receptor Melanocortin-3 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(CC2)NC1=O	10.1021/jm0202526
	122178164	121232	0	None	-158	2	Mouse	5.6	pKd	=	5.6	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL	1027	12	10	10	-0.1	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)C(Cc2cccc3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	CHEMBL3577993	121232	0	None	-158	2	Mouse	5.6	pKd	=	5.6	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL	1027	12	10	10	-0.1	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)C(Cc2cccc3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	CHEMBL1161318	208482	0	None	-79	2	Human	6.5	pKd	=	6.5	Binding	pA2 value for human Melanocortin-3 receptorpA2 value for human Melanocortin-3 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(CCCCC2)NC1=O	10.1021/jm0202526
	CHEMBL3577981	211726	1	None	-31	3	Mouse	6.4	pKd	=	6.4	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	CHEMBL1161321	208484	0	None	-19	2	Human	6.4	pKd	=	6.4	Binding	pA2 value for human Melanocortin-3 receptorpA2 value for human Melanocortin-3 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(Cc3ccccc3C2)NC1=O	10.1021/jm0202526
	118735604	118851	0	None	-251	2	Mouse	5.4	pKd	=	5.4	Binding	Competitive antagonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells assessed as inhibition of MTII-induced response after 6 hrs by Schild analysisCompetitive antagonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells assessed as inhibition of MTII-induced response after 6 hrs by Schild analysis	ChEMBL	860	18	10	6	2.0	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/ml500340z
	CHEMBL3422427	118851	0	None	-251	2	Mouse	5.4	pKd	=	5.4	Binding	Competitive antagonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells assessed as inhibition of MTII-induced response after 6 hrs by Schild analysisCompetitive antagonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells assessed as inhibition of MTII-induced response after 6 hrs by Schild analysis	ChEMBL	860	18	10	6	2.0	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/ml500340z
	CHEMBL440801	213846	0	None	-25	2	Human	8.3	pKd	=	8.3	Binding	pA2 against human melanocortin receptor, hMC3RpA2 against human melanocortin receptor, hMC3R	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(I)cc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC1=O	10.1021/jm0303103
	CHEMBL2096742	209183	0	None	-5	2	Human	8.3	pKd	=	8.3	Binding	pA2 value for the compound against human Melanocortin 3 receptorpA2 value for the compound against human Melanocortin 3 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm0303103
	CHEMBL1161323	208486	0	None	-5	2	Human	8.2	pKd	=	8.2	Binding	pA2 value for human Melanocortin-3 receptorpA2 value for human Melanocortin-3 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2C[C@@]3(C)CCCC[C@@]3(C)N2C1=O	10.1021/jm0202526
	CHEMBL3577977	211722	0	None	-3	2	Mouse	6.2	pKd	=	6.2	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O)[C@@H](C)O)[C@@H](C)O	10.1021/acs.jmedchem.5b00184
	CHEMBL3577978	211723	0	None	-10	2	Mouse	6.2	pKd	=	6.2	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@H](C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CSSC[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC1=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2)[C@@H](C)O	10.1021/acs.jmedchem.5b00184
	CHEMBL3577982	211727	0	None	-3	2	Mouse	6.2	pKd	=	6.2	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	CHEMBL3578003	211734	0	None	-	1	Mouse	6.2	pKd	=	6.2	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	CHEMBL1161316	208481	0	None	-63	2	Human	6.2	pKd	=	6.2	Binding	pA2 value for human Melanocortin-3 receptorpA2 value for human Melanocortin-3 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(CCCC2)NC1=O	10.1021/jm0202526
	122178157	121226	0	None	-50	2	Mouse	6.1	pKd	=	6.1	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL	1027	12	10	10	-0.1	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)C(Cc2cccc3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	CHEMBL3577986	121226	0	None	-50	2	Mouse	6.1	pKd	=	6.1	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL	1027	12	10	10	-0.1	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)C(Cc2cccc3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	CHEMBL3577976	211721	0	None	-2	2	Mouse	6.1	pKd	=	6.1	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O)[C@@H](C)O	10.1021/acs.jmedchem.5b00184
	CHEMBL3578002	211733	0	None	-	1	Mouse	6.1	pKd	=	6.1	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](N)[C@@H](C)O)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	CHEMBL2372588	210249	0	None	-316	2	Human	6.1	pKd	=	6.1	Binding	pA2 value for human Melanocortin-3 receptorpA2 value for human Melanocortin-3 receptor	ChEMBL		None	None	None		CCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2Cc3ccccc3N2C1=O	10.1021/jm0202526
	162643092	181700	0	None	-1	2	Human	10.7	pKi	=	10.7	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1108	17	14	11	0.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3cc(Cl)ccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4777048	181700	0	None	-1	2	Human	10.7	pKi	=	10.7	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1108	17	14	11	0.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3cc(Cl)ccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162643092	181700	0	None	-1	2	Human	10.7	pKi	=	10.7	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1108	17	14	11	0.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3cc(Cl)ccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4777048	181700	0	None	-1	2	Human	10.7	pKi	=	10.7	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1108	17	14	11	0.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3cc(Cl)ccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162673650	183029	0	None	-1	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1108	17	14	11	0.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3c(Cl)cccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4794121	183029	0	None	-1	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1108	17	14	11	0.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3c(Cl)cccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162673650	183029	0	None	-1	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1108	17	14	11	0.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3c(Cl)cccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4794121	183029	0	None	-1	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1108	17	14	11	0.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3c(Cl)cccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162676295	183429	0	None	-2	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1092	17	14	11	0.3	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3cc(F)ccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4798971	183429	0	None	-2	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1092	17	14	11	0.3	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3cc(F)ccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162676295	183429	0	None	-2	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1092	17	14	11	0.3	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3cc(F)ccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4798971	183429	0	None	-2	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1092	17	14	11	0.3	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3cc(F)ccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL414718	213128	0	None	-1	4	Human	10.0	pKi	=	10.0	Binding	Inhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cellsInhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(N)=O	10.1021/jm0501432
	1325	3573	14	None	-5	7	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	6440621	3573	14	None	-5	7	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	9898183	3573	14	None	-5	7	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	CHEMBL3422426	3573	14	None	-5	7	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	1325	3573	14	None	-5	7	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	6440621	3573	14	None	-5	7	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	9898183	3573	14	None	-5	7	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	CHEMBL3422426	3573	14	None	-5	7	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	162673931	183034	0	None	-8	2	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1098	17	13	13	0.4	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cc2cn(nn2)CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4794168	183034	0	None	-8	2	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1098	17	13	13	0.4	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cc2cn(nn2)CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162673931	183034	0	None	-8	2	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1098	17	13	13	0.4	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cc2cn(nn2)CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4794168	183034	0	None	-8	2	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1098	17	13	13	0.4	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cc2cn(nn2)CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL2370968	209948	0	None	1	3	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm030119t
	CHEMBL442504	213893	0	None	-3	3	Human	9.6	pKi	=	9.6	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm010165y
	CHEMBL415165	213153	0	None	-2	5	Human	9.6	pKi	=	9.6	Binding	Inhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cellsInhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm0501432
	162668987	182566	0	None	-15	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1092	17	14	11	0.3	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3c(F)cccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4788071	182566	0	None	-15	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1092	17	14	11	0.3	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3c(F)cccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162668987	182566	0	None	-15	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1092	17	14	11	0.3	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3c(F)cccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4788071	182566	0	None	-15	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1092	17	14	11	0.3	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3c(F)cccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162672763	183100	0	None	-13	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1092	17	14	11	0.3	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccc(F)cc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4794990	183100	0	None	-13	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1092	17	14	11	0.3	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccc(F)cc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162672763	183100	0	None	-13	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1092	17	14	11	0.3	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccc(F)cc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4794990	183100	0	None	-13	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1092	17	14	11	0.3	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccc(F)cc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162672255	182847	0	None	-13	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1100	18	14	11	0.6	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4791788	182847	0	None	-13	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1100	18	14	11	0.6	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162672255	182847	0	None	-13	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1100	18	14	11	0.6	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4791788	182847	0	None	-13	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1100	18	14	11	0.6	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162672837	182997	0	None	-18	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1098	17	13	13	0.4	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cc2cnnn2CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4793821	182997	0	None	-18	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1098	17	13	13	0.4	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cc2cnnn2CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162672837	182997	0	None	-18	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1098	17	13	13	0.4	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cc2cnnn2CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4793821	182997	0	None	-18	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1098	17	13	13	0.4	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cc2cnnn2CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	168277761	190276	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2342	37	34	29	-3.4	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCN)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5175981	190276	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2342	37	34	29	-3.4	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCN)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	1324	301	25	None	-2	4	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00552-3
	16154396	301	25	None	-2	4	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00552-3
	16197727	301	25	None	-2	4	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00552-3
	44285019	301	25	None	-2	4	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00552-3
	57514683	301	25	None	-2	4	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00552-3
	91898441	301	25	None	-2	4	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00552-3
	CHEMBL441738	301	25	None	-2	4	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00552-3
	DB04931	301	25	None	-2	4	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		None	10.1016/s0960-894x(03)00552-3
	162677133	183533	0	None	-19	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1108	17	14	11	0.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccc(Cl)cc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4800268	183533	0	None	-19	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1108	17	14	11	0.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccc(Cl)cc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162677133	183533	0	None	-19	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1108	17	14	11	0.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccc(Cl)cc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4800268	183533	0	None	-19	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1108	17	14	11	0.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccc(Cl)cc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	1324	301	25	None	-2	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		None	10.1021/jm201489a
	16154396	301	25	None	-2	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		None	10.1021/jm201489a
	16197727	301	25	None	-2	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		None	10.1021/jm201489a
	44285019	301	25	None	-2	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		None	10.1021/jm201489a
	57514683	301	25	None	-2	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		None	10.1021/jm201489a
	91898441	301	25	None	-2	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		None	10.1021/jm201489a
	CHEMBL441738	301	25	None	-2	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		None	10.1021/jm201489a
	DB04931	301	25	None	-2	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		None	10.1021/jm201489a
	CHEMBL2370964	209944	0	None	1	3	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm030119t
	CHEMBL385465	212328	0	None	-10	3	Human	9.0	pKi	=	9.0	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL		None	None	None		CC(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm010165y
	44415913	79922	0	None	-2	3	Human	9.0	pKi	=	9	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	736	16	6	7	0.8	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL212614	79922	0	None	-2	3	Human	9.0	pKi	=	9	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	736	16	6	7	0.8	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	44415914	139245	0	None	-1	3	Human	9.0	pKi	=	9	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	762	16	6	7	1.8	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL379054	139245	0	None	-1	3	Human	9.0	pKi	=	9	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	762	16	6	7	1.8	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	44415919	141563	0	None	-2	3	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	780	16	6	7	1.9	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL385000	141563	0	None	-2	3	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	780	16	6	7	1.9	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL2370154	209778	0	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsBinding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm020021z
	CHEMBL266879	210683	0	None	-6	4	Human	8.8	pKi	=	8.8	Binding	Inhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cellsInhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O	10.1021/jm0501432
	162665450	182272	0	None	-10	2	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3ccc4ccccc4c3)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4784053	182272	0	None	-10	2	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3ccc4ccccc4c3)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162665450	182272	0	None	-10	2	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3ccc4ccccc4c3)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4784053	182272	0	None	-10	2	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3ccc4ccccc4c3)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	168273645	190301	0	None	-24	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	5162	106	68	67	-6.5	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCNC(=O)CCOCCOCCOCCOCCOCCC(=O)NCCOCCOCCNC(=O)OCC3C4CCc5c6nnc(c5CCC43)SC[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](CS6)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC3=O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5176443	190301	0	None	-24	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	5162	106	68	67	-6.5	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCNC(=O)CCOCCOCCOCCOCCOCCC(=O)NCCOCCOCCNC(=O)OCC3C4CCc5c6nnc(c5CCC43)SC[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](CS6)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC3=O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	16172929	212978	15	None	-12	4	Human	8.0	pKi	=	8.0	Binding	Inhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cellsInhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm0501432
	CHEMBL412536	212978	15	None	-12	4	Human	8.0	pKi	=	8.0	Binding	Inhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cellsInhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cells	ChEMBL		None	None	None		None	10.1021/jm0501432
	168289404	191288	0	None	-15	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2134	33	32	28	-5.0	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(nn3)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5191309	191288	0	None	-15	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2134	33	32	28	-5.0	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(nn3)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	122178168	121235	0	None	-25	2	Mouse	7.0	pKi	=	7	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL	963	12	10	10	-0.7	C[C@@H]1NC(=O)C(CCN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	CHEMBL3577997	121235	0	None	-25	2	Mouse	7.0	pKi	=	7	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL	963	12	10	10	-0.7	C[C@@H]1NC(=O)C(CCN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	CHEMBL3577999	211730	0	None	-19	2	Mouse	7.0	pKi	=	7	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	CHEMBL5087814	215096	0	None	-26	3	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](C)C(=O)N2	10.1021/acs.jmedchem.1c00095
	44400811	68612	0	None	-416	2	Human	6.0	pKi	=	6	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	615	10	3	5	5.7	CC(C)(C)NC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	CHEMBL191857	68612	0	None	-416	2	Human	6.0	pKi	=	6	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	615	10	3	5	5.7	CC(C)(C)NC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	9915636	66794	0	None	-58	4	Human	6.0	pKi	=	6	Binding	Binding affinity towards human melanocortin 3 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligandBinding affinity towards human melanocortin 3 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligand	ChEMBL	553	12	3	6	3.5	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2004.08.055
	CHEMBL186083	66794	0	None	-58	4	Human	6.0	pKi	=	6	Binding	Binding affinity towards human melanocortin 3 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligandBinding affinity towards human melanocortin 3 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligand	ChEMBL	553	12	3	6	3.5	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2004.08.055
	122178158	121227	0	None	-10	2	Mouse	6.0	pKi	=	6	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL	1027	12	10	10	-0.1	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)C(Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	CHEMBL3577987	121227	0	None	-10	2	Mouse	6.0	pKi	=	6	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL	1027	12	10	10	-0.1	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)C(Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	44434860	90013	0	None	-3	4	Human	5.0	pKi	=	5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	449	8	2	2	5.9	N[C@H]1CC[C@H](N(C/C(Cl)=C/c2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL238159	90013	0	None	-3	4	Human	5.0	pKi	=	5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	449	8	2	2	5.9	N[C@H]1CC[C@H](N(C/C(Cl)=C/c2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL5094168	215456	0	None	-707	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL5090946	215262	0	None	-75	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](C)C(=O)N2	10.1021/acs.jmedchem.1c00095
	44401341	135648	0	None	-3	2	Human	5.0	pKi	=	5.0	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	630	13	5	4	4.5	N=C(N)NCCC[C@H](NC(=O)c1ccccc1-c1ccccc1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	CHEMBL372965	135648	0	None	-3	2	Human	5.0	pKi	=	5.0	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	630	13	5	4	4.5	N=C(N)NCCC[C@H](NC(=O)c1ccccc1-c1ccccc1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	176	397	66	None	-6	31	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2157	397	66	None	-6	31	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2566	397	66	None	-6	31	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	CHEMBL633	397	66	None	-6	31	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	DB01118	397	66	None	-6	31	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	59149264	76773	0	None	-85	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1946	57	23	26	-3.0	CCCC[C@H](NC(=O)[C@H](CN(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	70684624	76773	0	None	-85	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1946	57	23	26	-3.0	CCCC[C@H](NC(=O)[C@H](CN(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	91929810	76773	0	None	-85	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1946	57	23	26	-3.0	CCCC[C@H](NC(=O)[C@H](CN(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	CHEMBL2069317	76773	0	None	-85	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1946	57	23	26	-3.0	CCCC[C@H](NC(=O)[C@H](CN(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	168277916	190653	0	None	-17	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	4986	94	68	63	-6.6	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCNC(=O)CCOCCOCCOCCOCCOCCC(=O)NCCNC(=O)OCC3C4CCc5c6nnc(c5CCC43)SC[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](CS6)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC3=O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5181812	190653	0	None	-17	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	4986	94	68	63	-6.6	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCNC(=O)CCOCCOCCOCCOCCOCCC(=O)NCCNC(=O)OCC3C4CCc5c6nnc(c5CCC43)SC[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](CS6)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC3=O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	168272660	190409	0	None	-14	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2202	33	32	24	-2.1	CCCC[C@@H]1NC(=O)[C@@H]2CSc3c(F)c(F)c(c(F)c3F)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5178164	190409	0	None	-14	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2202	33	32	24	-2.1	CCCC[C@@H]1NC(=O)[C@@H]2CSc3c(F)c(F)c(c(F)c3F)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	44322869	106133	0	None	6	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsBinding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	867	11	12	9	-0.4	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL313690	106133	0	None	6	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsBinding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	867	11	12	9	-0.4	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	44322895	163346	0	None	-18	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	811	21	10	8	1.3	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)COc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL419307	163346	0	None	-18	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	811	21	10	8	1.3	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)COc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	168285313	191377	0	None	-3	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	2967	62	33	39	-5.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC2=O)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5192562	191377	0	None	-3	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	2967	62	33	39	-5.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC2=O)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	44433294	153019	0	None	-575	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity at human MC3RBinding affinity at human MC3R	ChEMBL	619	11	2	5	4.6	CC(C)C[C@H](NC(=O)CCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmcl.2007.07.097
	CHEMBL397580	153019	0	None	-575	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity at human MC3RBinding affinity at human MC3R	ChEMBL	619	11	2	5	4.6	CC(C)C[C@H](NC(=O)CCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmcl.2007.07.097
	CHEMBL2070254	209162	0	None	-31	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	44397030	67339	0	None	-131	4	Human	6.0	pKi	=	6.0	Binding	Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells	ChEMBL	607	11	3	6	3.6	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(C2(CNC(=O)Cc3cccs3)CCCCC2)CC1	10.1016/j.bmcl.2005.05.017
	CHEMBL188651	67339	0	None	-131	4	Human	6.0	pKi	=	6.0	Binding	Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells	ChEMBL	607	11	3	6	3.6	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(C2(CNC(=O)Cc3cccs3)CCCCC2)CC1	10.1016/j.bmcl.2005.05.017
	6918850	125396	1	None	-316	4	Human	6.0	pKi	=	6.0	Binding	Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells	ChEMBL	631	12	3	6	3.6	COc1ccc(CC(=O)NCC2(N3CCN(C(=O)[C@@H](Cc4ccc(Cl)cc4Cl)NC(=O)CCN)CC3)CCCCC2)cc1	10.1016/j.bmcl.2005.05.017
	CHEMBL364560	125396	1	None	-316	4	Human	6.0	pKi	=	6.0	Binding	Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells	ChEMBL	631	12	3	6	3.6	COc1ccc(CC(=O)NCC2(N3CCN(C(=O)[C@@H](Cc4ccc(Cl)cc4Cl)NC(=O)CCN)CC3)CCCCC2)cc1	10.1016/j.bmcl.2005.05.017
	10270570	89004	0	None	-2	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	371	6	2	2	4.4	CC(c1ccc2ccccc2c1)N(CCN)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL236450	89004	0	None	-2	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	371	6	2	2	4.4	CC(c1ccc2ccccc2c1)N(CCN)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44401592	125164	0	None	-4	2	Human	6.0	pKi	=	6.0	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	607	13	6	4	3.2	N=C(N)NCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	CHEMBL364519	125164	0	None	-4	2	Human	6.0	pKi	=	6.0	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	607	13	6	4	3.2	N=C(N)NCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	46905545	10268	0	None	-2	2	Human	5.0	pKi	=	5.0	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	631	14	7	6	1.4	CC(N)=O.N=C(N)NCCC[C@H](NC(=O)CCc1c[nH]cn1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	CHEMBL1161792	10268	0	None	-2	2	Human	5.0	pKi	=	5.0	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	631	14	7	6	1.4	CC(N)=O.N=C(N)NCCC[C@H](NC(=O)CCc1c[nH]cn1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	44415972	79854	0	None	-5	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	549	13	6	5	0.9	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)Cc1ccc(F)cc1	10.1016/j.bmcl.2006.05.087
	CHEMBL212332	79854	0	None	-5	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	549	13	6	5	0.9	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)Cc1ccc(F)cc1	10.1016/j.bmcl.2006.05.087
	CHEMBL5078687	214557	0	None	-75	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	11845450	138444	0	None	-91	3	Human	6.9	pKi	=	6.9	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	652	15	5	6	2.6	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL377465	138444	0	None	-91	3	Human	6.9	pKi	=	6.9	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	652	15	5	6	2.6	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	51346770	58197	0	None	-10	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in BHK cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in BHK cells	ChEMBL	643	11	2	8	3.5	COCC(=O)N[C@H]1Cc2ccc(OC)c(c2)Cc2ccc(cc2)Oc2cccc(c2)CN(CCCN2CCN(CCCN)CC2)C1=O	10.1016/j.bmcl.2011.01.011
	CHEMBL1682209	58197	0	None	-10	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in BHK cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in BHK cells	ChEMBL	643	11	2	8	3.5	COCC(=O)N[C@H]1Cc2ccc(OC)c(c2)Cc2ccc(cc2)Oc2cccc(c2)CN(CCCN2CCN(CCCN)CC2)C1=O	10.1016/j.bmcl.2011.01.011
	44413876	79715	0	None	-93	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	710	18	8	7	0.4	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(C)=O	10.1016/j.bmcl.2006.05.087
	CHEMBL211699	79715	0	None	-93	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	710	18	8	7	0.4	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(C)=O	10.1016/j.bmcl.2006.05.087
	44413876	79715	0	None	-93	3	Human	5.9	pKi	=	5.9	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	710	18	8	7	0.4	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(C)=O	10.1021/jm060384p
	CHEMBL211699	79715	0	None	-93	3	Human	5.9	pKi	=	5.9	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	710	18	8	7	0.4	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(C)=O	10.1021/jm060384p
	CHEMBL2370967	209947	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm030119t
	44323234	168032	0	None	7	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsBinding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	903	11	12	9	0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL432377	168032	0	None	7	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsBinding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	903	11	12	9	0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	44347331	16295	0	None	-181	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	794	10	9	7	1.3	CCC1CC(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(N)=O)CCCCNC1=O	10.1021/jm010165y
	CHEMBL122773	16295	0	None	-181	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	794	10	9	7	1.3	CCC1CC(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(N)=O)CCCCNC1=O	10.1021/jm010165y
	16007264	79691	0	None	-63	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	572	9	2	4	5.5	CC(C)C[C@H](NC(=O)CN)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)CCc2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2006.05.088
	CHEMBL211564	79691	0	None	-63	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	572	9	2	4	5.5	CC(C)C[C@H](NC(=O)CN)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)CCc2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2006.05.088
	16007264	79691	0	None	-63	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]NDPMSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC3R expressed in HEK293 cells	ChEMBL	572	9	2	4	5.5	CC(C)C[C@H](NC(=O)CN)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)CCc2ccc(Cl)cc2Cl)CC1	10.1021/jm701137s
	CHEMBL211564	79691	0	None	-63	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]NDPMSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC3R expressed in HEK293 cells	ChEMBL	572	9	2	4	5.5	CC(C)C[C@H](NC(=O)CN)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)CCc2ccc(Cl)cc2Cl)CC1	10.1021/jm701137s
	71452732	79005	0	None	-1	4	Human	5.9	pKi	=	5.9	Binding	Inhibition of [125I]-NDP MSH binding towards human melanocortin 3 receptorInhibition of [125I]-NDP MSH binding towards human melanocortin 3 receptor	ChEMBL	697	8	2	6	4.2	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2cccc3c2CN(S(=O)(=O)c2ccccc2)CC3)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.07.035
	CHEMBL2113139	79005	0	None	-1	4	Human	5.9	pKi	=	5.9	Binding	Inhibition of [125I]-NDP MSH binding towards human melanocortin 3 receptorInhibition of [125I]-NDP MSH binding towards human melanocortin 3 receptor	ChEMBL	697	8	2	6	4.2	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2cccc3c2CN(S(=O)(=O)c2ccccc2)CC3)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.07.035
	71461657	79010	0	None	-4	4	Human	5.9	pKi	=	5.9	Binding	Inhibition of [125I]-NDP MSH binding towards human melanocortin 3 receptorInhibition of [125I]-NDP MSH binding towards human melanocortin 3 receptor	ChEMBL	556	6	2	4	4.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2cccc3c2CCCC3)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.07.035
	CHEMBL2113144	79010	0	None	-4	4	Human	5.9	pKi	=	5.9	Binding	Inhibition of [125I]-NDP MSH binding towards human melanocortin 3 receptorInhibition of [125I]-NDP MSH binding towards human melanocortin 3 receptor	ChEMBL	556	6	2	4	4.3	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2cccc3c2CCCC3)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.07.035
	44435220	89223	0	None	-2	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	609	10	2	3	8.9	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)c3cc4cc(OCc5ccccc5)ccc4[nH]3)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL236803	89223	0	None	-2	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	609	10	2	3	8.9	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)c3cc4cc(OCc5ccccc5)ccc4[nH]3)CC2)CC1	10.1016/j.bmc.2007.06.003
	10293285	89583	0	None	-2	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	382	7	1	2	4.9	NCCCN(Cc1ccc2ccccc2c1)C(=O)Cc1ccc2ccccc2c1	10.1016/j.bmc.2007.06.003
	CHEMBL237528	89583	0	None	-2	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	382	7	1	2	4.9	NCCCN(Cc1ccc2ccccc2c1)C(=O)Cc1ccc2ccccc2c1	10.1016/j.bmc.2007.06.003
	10137615	89707	0	None	-4	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	431	9	2	2	5.4	CC(c1ccc(C(F)(F)F)cc1)N(CCCCCN)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237692	89707	0	None	-4	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	431	9	2	2	5.4	CC(c1ccc(C(F)(F)F)cc1)N(CCCCCN)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434855	90001	0	None	-10	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	7.5	CC1CC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	CHEMBL238154	90001	0	None	-10	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	7.5	CC1CC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	44434766	154690	0	None	-10	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	510	9	2	3	6.9	N#Cc1ccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL399810	154690	0	None	-10	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	510	9	2	3	6.9	N#Cc1ccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	59149266	76897	0	None	-707	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1918	56	24	26	-3.6	CCCC[C@H](NC(=O)[C@@H](N)CNC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	70693081	76897	0	None	-707	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1918	56	24	26	-3.6	CCCC[C@H](NC(=O)[C@@H](N)CNC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	91929807	76897	0	None	-707	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1918	56	24	26	-3.6	CCCC[C@H](NC(=O)[C@@H](N)CNC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	CHEMBL2070250	76897	0	None	-707	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1918	56	24	26	-3.6	CCCC[C@H](NC(=O)[C@@H](N)CNC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	168296647	192451	0	None	-190	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	1319	15	14	15	0.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSCc2ccccc2CSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5208830	192451	0	None	-190	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	1319	15	14	15	0.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSCc2ccccc2CSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	11845813	139779	0	None	-4	3	Human	5.9	pKi	=	5.9	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	473	10	3	4	3.0	NC(N)=NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@H](N)Cc1ccccc1	10.1021/jm060384p
	CHEMBL379879	139779	0	None	-4	3	Human	5.9	pKi	=	5.9	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	473	10	3	4	3.0	NC(N)=NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@H](N)Cc1ccccc1	10.1021/jm060384p
	1338	3778	43	None	-75	4	Human	6.9	pKi	=	6.9	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2007.11.109
	9938402	3778	43	None	-75	4	Human	6.9	pKi	=	6.9	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2007.11.109
	CHEMBL339053	3778	43	None	-75	4	Human	6.9	pKi	=	6.9	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2007.11.109
	44413829	78037	0	None	-10	3	Human	5.9	pKi	=	5.9	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	584	12	5	5	3.5	N=C(N)NCCC[C@H]1C[C@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCCCN1	10.1021/jm060384p
	CHEMBL210011	78037	0	None	-10	3	Human	5.9	pKi	=	5.9	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	584	12	5	5	3.5	N=C(N)NCCC[C@H]1C[C@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCCCN1	10.1021/jm060384p
	25133556	188825	0	None	-23	3	Human	6.9	pKi	=	6.9	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	629	11	3	5	3.2	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1CCNCC1	10.1021/jm800525p
	CHEMBL506762	188825	0	None	-23	3	Human	6.9	pKi	=	6.9	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	629	11	3	5	3.2	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1CCNCC1	10.1021/jm800525p
	44569175	188798	0	None	-32	3	Human	6.9	pKi	=	6.9	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	629	11	3	5	2.5	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1CCC(=O)N1	10.1021/jm800525p
	CHEMBL506272	188798	0	None	-32	3	Human	6.9	pKi	=	6.9	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	629	11	3	5	2.5	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1CCC(=O)N1	10.1021/jm800525p
	168277543	190651	0	None	-128	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	1347	15	14	15	1.3	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSCc2ccc(cc2)CSCC[C@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5181752	190651	0	None	-128	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	1347	15	14	15	1.3	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSCc2ccc(cc2)CSCC[C@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	59149255	76899	0	None	-50	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1960	58	24	26	-2.5	CCCC[C@H](NC(=O)[C@H](CNC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	70693082	76899	0	None	-50	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1960	58	24	26	-2.5	CCCC[C@H](NC(=O)[C@H](CNC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	91929809	76899	0	None	-50	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1960	58	24	26	-2.5	CCCC[C@H](NC(=O)[C@H](CNC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	CHEMBL2070252	76899	0	None	-50	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1960	58	24	26	-2.5	CCCC[C@H](NC(=O)[C@H](CNC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	11993702	3566	18	None	-3	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.2c00793
	5416	3566	18	None	-3	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.2c00793
	9272	3566	18	None	-3	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.2c00793
	CHEMBL3301624	3566	18	None	-3	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.2c00793
	DB11700	3566	18	None	-3	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.2c00793
	11993702	3566	18	None	-3	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00095
	5416	3566	18	None	-3	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00095
	9272	3566	18	None	-3	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00095
	CHEMBL3301624	3566	18	None	-3	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00095
	DB11700	3566	18	None	-3	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00095
	168276507	190241	0	None	-33	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2158	33	32	24	-2.3	CCCC[C@@H]1NC(=O)[C@@H]2CSCc3cccc(c3)CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5175487	190241	0	None	-33	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2158	33	32	24	-2.3	CCCC[C@@H]1NC(=O)[C@@H]2CSCc3cccc(c3)CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	44322896	167948	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	789	22	10	7	1.6	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL431801	167948	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	789	22	10	7	1.6	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	168293710	192142	0	None	-56	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2158	33	32	24	-2.3	CCCC[C@@H]1NC(=O)[C@@H]2CSCc3ccc(cc3)CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5203986	192142	0	None	-56	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2158	33	32	24	-2.3	CCCC[C@@H]1NC(=O)[C@@H]2CSCc3ccc(cc3)CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	44322958	106985	0	None	-3	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	727	18	9	7	0.4	CC(C)(C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL315356	106985	0	None	-3	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	727	18	9	7	0.4	CC(C)(C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	122178167	121234	0	None	-162	2	Mouse	6.9	pKi	=	6.9	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL	948	11	10	10	-1.1	C[C@@H]1NC(=O)C(CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	CHEMBL3577996	121234	0	None	-162	2	Mouse	6.9	pKi	=	6.9	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL	948	11	10	10	-1.1	C[C@@H]1NC(=O)C(CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	44432932	87725	0	None	-38	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]NDP-alphaMSH from human melanocortin 3 receptor expressed in CHOK1 cellsDisplacement of [125I]NDP-alphaMSH from human melanocortin 3 receptor expressed in CHOK1 cells	ChEMBL	574	14	2	6	6.6	CNC(=O)c1ccc(Nc2nc3ccc(C(=O)N(CCC(C)C)CCC(C)C)cc3n2CCCN2CCCCC2)cc1	10.1016/j.bmcl.2007.06.010
	CHEMBL233758	87725	0	None	-38	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]NDP-alphaMSH from human melanocortin 3 receptor expressed in CHOK1 cellsDisplacement of [125I]NDP-alphaMSH from human melanocortin 3 receptor expressed in CHOK1 cells	ChEMBL	574	14	2	6	6.6	CNC(=O)c1ccc(Nc2nc3ccc(C(=O)N(CCC(C)C)CCC(C)C)cc3n2CCCN2CCCCC2)cc1	10.1016/j.bmcl.2007.06.010
	44400863	69135	0	None	-288	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	602	11	2	6	5.8	CC(C)OC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	CHEMBL192464	69135	0	None	-288	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	602	11	2	6	5.8	CC(C)OC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	44456219	155414	0	None	-275	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity to MC3RBinding affinity to MC3R	ChEMBL	637	10	1	6	5.0	Cc1ccc(N2CCN(C(=O)[C@H]3CN(C4CCOCC4)C[C@@H]3c3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1016/j.bmcl.2007.10.115
	CHEMBL403806	155414	0	None	-275	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity to MC3RBinding affinity to MC3R	ChEMBL	637	10	1	6	5.0	Cc1ccc(N2CCN(C(=O)[C@H]3CN(C4CCOCC4)C[C@@H]3c3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1016/j.bmcl.2007.10.115
	CHEMBL3577979	211724	0	None	-8	2	Mouse	5.9	pKi	=	5.9	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccc(O)cc2)NC1=O	10.1021/acs.jmedchem.5b00184
	16046215	80060	0	None	-51	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]NDP-MSH from human MC3R stably expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R stably expressed in HEK293 cells	ChEMBL	441	7	1	3	5.2	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](N)CC(C)C)c1	10.1016/j.bmcl.2006.06.075
	CHEMBL213122	80060	0	None	-51	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]NDP-MSH from human MC3R stably expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R stably expressed in HEK293 cells	ChEMBL	441	7	1	3	5.2	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](N)CC(C)C)c1	10.1016/j.bmcl.2006.06.075
	16046215	80060	0	None	-51	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]NDPMSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC3R expressed in HEK293 cells	ChEMBL	441	7	1	3	5.2	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](N)CC(C)C)c1	10.1021/jm701137s
	CHEMBL213122	80060	0	None	-51	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]NDPMSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC3R expressed in HEK293 cells	ChEMBL	441	7	1	3	5.2	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](N)CC(C)C)c1	10.1021/jm701137s
	44434843	88671	0	None	-3	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	587	11	4	2	7.6	N=C(N)NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL236020	88671	0	None	-3	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	587	11	4	2	7.6	N=C(N)NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434854	90000	0	None	-8	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	573	10	2	2	8.6	CC1CC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	CHEMBL238153	90000	0	None	-8	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	573	10	2	2	8.6	CC1CC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	44434648	148135	0	None	-2	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	413	10	2	2	5.1	NCCCCCN(CCc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL393558	148135	0	None	-2	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	413	10	2	2	5.1	NCCCCCN(CCc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	168285101	191620	0	None	-190	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	1347	15	14	15	1.3	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSCc2ccccc2CSCC[C@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5195937	191620	0	None	-190	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	1347	15	14	15	1.3	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSCc2ccccc2CSCC[C@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5080489	214666	0	None	-16	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N2	10.1021/acs.jmedchem.1c00095
	2247	504	81	None	-147	42	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	249	504	81	None	-147	42	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	2603	504	81	None	-147	42	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	CHEMBL296419	504	81	None	-147	42	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	DB00637	504	81	None	-147	42	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	44401573	71169	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	568	13	5	4	2.8	N=C(N)NCCC[C@H](NC(=O)Cc1ccccc1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	CHEMBL195638	71169	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	568	13	5	4	2.8	N=C(N)NCCC[C@H](NC(=O)Cc1ccccc1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	CHEMBL420167	213219	0	None	-8	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL		None	None	None		NC(=O)[C@H]1CCCCNC(=O)C[C@H](N)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1	10.1021/jm010165y
	CHEMBL266417	210660	0	None	-8	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm010165y
	10260053	168179	0	None	4	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsBinding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	871	27	12	10	-1.1	NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm020021z
	CHEMBL433413	168179	0	None	4	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsBinding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	871	27	12	10	-1.1	NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm020021z
	44322787	105937	0	None	-12	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	791	21	11	8	0.2	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)C(O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL312998	105937	0	None	-12	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	791	21	11	8	0.2	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)C(O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL2370965	209945	0	None	-1	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm030119t
	44433439	89895	0	None	-165	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity at human MC3 receptorBinding affinity at human MC3 receptor	ChEMBL	538	6	1	5	4.8	Cc1ccc(N2CCN(C(=O)[C@H]3CN(C4CCOCC4)C[C@@H]3c3ccc(Cl)cc3)CC2)c([C@@H](N)C(C)C)c1	10.1016/j.bmcl.2007.09.079
	CHEMBL237976	89895	0	None	-165	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity at human MC3 receptorBinding affinity at human MC3 receptor	ChEMBL	538	6	1	5	4.8	Cc1ccc(N2CCN(C(=O)[C@H]3CN(C4CCOCC4)C[C@@H]3c3ccc(Cl)cc3)CC2)c([C@@H](N)C(C)C)c1	10.1016/j.bmcl.2007.09.079
	44323212	168695	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsBinding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	787	9	10	8	-1.0	C[C@@H]1NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC1=O	10.1021/jm020021z
	CHEMBL436903	168695	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsBinding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	787	9	10	8	-1.0	C[C@@H]1NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC1=O	10.1021/jm020021z
	11180881	66791	1	None	-93	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human melanocortin 3 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligandBinding affinity towards human melanocortin 3 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligand	ChEMBL	593	11	3	6	4.1	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)C1CCCNC1	10.1016/j.bmcl.2004.08.055
	CHEMBL186074	66791	1	None	-93	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human melanocortin 3 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligandBinding affinity towards human melanocortin 3 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligand	ChEMBL	593	11	3	6	4.1	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)C1CCCNC1	10.1016/j.bmcl.2004.08.055
	44395681	66840	0	None	-100	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human melanocortin 3 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligandBinding affinity towards human melanocortin 3 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligand	ChEMBL	567	13	3	6	3.8	NCCCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2004.08.055
	CHEMBL186289	66840	0	None	-100	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human melanocortin 3 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligandBinding affinity towards human melanocortin 3 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligand	ChEMBL	567	13	3	6	3.8	NCCCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2004.08.055
	44415417	80117	0	None	-12	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	465	7	1	3	5.5	CC(C)C[C@H](N)c1cccc(F)c1N1CCN(C(=O)CCc2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2006.05.088
	CHEMBL213380	80117	0	None	-12	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	465	7	1	3	5.5	CC(C)C[C@H](N)c1cccc(F)c1N1CCN(C(=O)CCc2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2006.05.088
	10304463	76745	0	None	-14	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cell	ChEMBL	615	11	1	5	5.6	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)c2cc3ccccc3cn2)CC1	10.1016/j.bmcl.2005.10.103
	CHEMBL206840	76745	0	None	-14	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cell	ChEMBL	615	11	1	5	5.6	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)c2cc3ccccc3cn2)CC1	10.1016/j.bmcl.2005.10.103
	9915636	66794	0	None	-58	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [125]NDP-MSH from human MC3receptor expressed in HEK293 cellsDisplacement of [125]NDP-MSH from human MC3receptor expressed in HEK293 cells	ChEMBL	553	12	3	6	3.5	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1021/jm049278i
	CHEMBL186083	66794	0	None	-58	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [125]NDP-MSH from human MC3receptor expressed in HEK293 cellsDisplacement of [125]NDP-MSH from human MC3receptor expressed in HEK293 cells	ChEMBL	553	12	3	6	3.5	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1021/jm049278i
	44265715	10153	0	None	-4	4	Human	4.9	pKi	=	4.9	Binding	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptor	ChEMBL	439	9	4	3	4.1	NC(N)=NCCC[C@H](NCc1ccc2ccccc2c1)C(=O)Nc1ccc2ccccc2c1	10.1016/s0960-894x(02)00089-6
	CHEMBL1159702	10153	0	None	-4	4	Human	4.9	pKi	=	4.9	Binding	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptor	ChEMBL	439	9	4	3	4.1	NC(N)=NCCC[C@H](NCc1ccc2ccccc2c1)C(=O)Nc1ccc2ccccc2c1	10.1016/s0960-894x(02)00089-6
	10108894	89708	0	None	-2	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	355	8	2	2	4.4	NCCCCCN(C(=O)Cc1c[nH]c2ccccc12)C1CCCCCC1	10.1016/j.bmc.2007.06.003
	CHEMBL237693	89708	0	None	-2	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	355	8	2	2	4.4	NCCCCCN(C(=O)Cc1c[nH]c2ccccc12)C1CCCCCC1	10.1016/j.bmc.2007.06.003
	44434697	148669	0	None	-6	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	543	10	2	4	6.8	COC(=O)c1ccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL393994	148669	0	None	-6	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	543	10	2	4	6.8	COC(=O)c1ccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	44434757	152717	0	None	-7	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	649	12	2	4	8.3	COc1cc(Br)c(/C=C/CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	CHEMBL397324	152717	0	None	-7	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	649	12	2	4	8.3	COc1cc(Br)c(/C=C/CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	25129105	176995	0	None	-23	3	Human	6.8	pKi	=	6.8	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	623	11	2	5	3.9	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)c1cccnc1	10.1021/jm800525p
	CHEMBL463047	176995	0	None	-23	3	Human	6.8	pKi	=	6.8	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	623	11	2	5	3.9	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)c1cccnc1	10.1021/jm800525p
	CHEMBL5081077	214694	0	None	-30	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CN1C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]1CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	44401418	123990	0	None	-2	2	Human	5.8	pKi	=	5.8	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	621	14	6	4	3.3	N=C(N)NCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCCc1ccccc1	10.1016/j.bmcl.2005.03.120
	CHEMBL362964	123990	0	None	-2	2	Human	5.8	pKi	=	5.8	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	621	14	6	4	3.3	N=C(N)NCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCCc1ccccc1	10.1016/j.bmcl.2005.03.120
	44413913	138648	0	None	-2	3	Human	5.8	pKi	=	5.8	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	672	16	6	7	0.2	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1C(=O)NCCN=C(N)N	10.1021/jm060384p
	CHEMBL377779	138648	0	None	-2	3	Human	5.8	pKi	=	5.8	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	672	16	6	7	0.2	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1C(=O)NCCN=C(N)N	10.1021/jm060384p
	CHEMBL2370963	209943	0	None	-10	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm030119t
	162670951	182814	0	None	-33	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1100	18	14	11	0.6	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3ccccc3)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4791306	182814	0	None	-33	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1100	18	14	11	0.6	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3ccccc3)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162670951	182814	0	None	-33	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1100	18	14	11	0.6	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3ccccc3)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4791306	182814	0	None	-33	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1100	18	14	11	0.6	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3ccccc3)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	42630327	155847	0	None	-5	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1119	32	19	14	-3.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CS)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CS)C(N)=O	10.1021/acs.jmedchem.8b00170
	CHEMBL4060381	155847	0	None	-5	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1119	32	19	14	-3.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CS)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CS)C(N)=O	10.1021/acs.jmedchem.8b00170
	CHEMBL407809	212662	0	None	-56	4	Human	7.8	pKi	=	7.8	Binding	Inhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cellsInhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm0501432
	CHEMBL409049	212722	0	None	-12	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@H]1C(=O)NCC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)CSSC1(C)C	10.1021/jm030119t
	CHEMBL438235	213736	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@H]1C(=O)NCC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)CSSC1(C)C	10.1021/jm030119t
	44347219	16548	0	None	-301	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	781	9	10	8	0.2	NNC(=O)[C@H]1CCCCNC(=O)CCC(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1	10.1021/jm010165y
	CHEMBL123938	16548	0	None	-301	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	781	9	10	8	0.2	NNC(=O)[C@H]1CCCCNC(=O)CCC(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1	10.1021/jm010165y
	44347105	113319	0	None	-13	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	724	9	10	7	-0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCC(C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL331728	113319	0	None	-13	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	724	9	10	7	-0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCC(C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	44393441	66399	0	None	-1	4	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards Melanocortin 3 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 3 receptor using [125I]NDP-MSH	ChEMBL	502	6	2	4	3.4	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	CHEMBL185195	66399	0	None	-1	4	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards Melanocortin 3 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 3 receptor using [125I]NDP-MSH	ChEMBL	502	6	2	4	3.4	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	44434662	88485	0	None	-4	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	377	11	2	2	4.6	NCCCCCN(Cc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL235137	88485	0	None	-4	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	377	11	2	2	4.6	NCCCCCN(Cc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434781	89875	0	None	-15	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	485	9	2	2	7.0	NC1CCC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL237919	89875	0	None	-15	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	485	9	2	2	7.0	NC1CCC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	5624	32663	14	None	-45	10	Human	4.8	pKi	=	4.8	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
	CHEMBL1203324	32663	14	None	-45	10	Human	4.8	pKi	=	4.8	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
	CHEMBL141343	32663	14	None	-45	10	Human	4.8	pKi	=	4.8	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
	44413970	138990	0	None	-34	3	Human	4.8	pKi	=	4.8	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	587	14	5	6	1.3	NC(=O)C[C@H](N)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL378571	138990	0	None	-34	3	Human	4.8	pKi	=	4.8	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	587	14	5	6	1.3	NC(=O)C[C@H](N)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N	10.1021/jm060384p
	44413938	138914	0	None	-2	3	Human	6.8	pKi	=	6.8	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	662	15	4	5	3.9	CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL378446	138914	0	None	-2	3	Human	6.8	pKi	=	6.8	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	662	15	4	5	3.9	CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	44569176	172521	0	None	-30	3	Human	6.8	pKi	=	6.8	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	629	11	3	5	3.3	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@H]1CCCCN1	10.1021/jm800525p
	CHEMBL448410	172521	0	None	-30	3	Human	6.8	pKi	=	6.8	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	629	11	3	5	3.3	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@H]1CCCCN1	10.1021/jm800525p
	11846669	80248	0	None	-5	3	Human	6.8	pKi	=	6.8	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	584	12	5	5	3.5	N=C(N)NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCCN1	10.1021/jm060384p
	CHEMBL213956	80248	0	None	-5	3	Human	6.8	pKi	=	6.8	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	584	12	5	5	3.5	N=C(N)NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCCN1	10.1021/jm060384p
	168271934	190061	0	None	-9	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2229	37	32	26	-3.7	C#CCCCCN1C(=O)C2=C(SC[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](CS2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2c[nH]c4ccccc24)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC3=O)C1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5172738	190061	0	None	-9	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2229	37	32	26	-3.7	C#CCCCCN1C(=O)C2=C(SC[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](CS2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2c[nH]c4ccccc24)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC3=O)C1=O	10.1021/acs.jmedchem.2c00793
	1323	2669	55	None	-72	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00170
	92432	2669	55	None	-72	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00170
	CHEMBL430239	2669	55	None	-72	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.8b00170
	44322977	111542	0	None	-2	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	714	18	11	8	-1.9	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)C(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL328117	111542	0	None	-2	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	714	18	11	8	-1.9	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)C(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	122178169	121236	0	None	-31	2	Mouse	6.8	pKi	=	6.8	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL	977	13	10	10	-0.4	C[C@@H]1NC(=O)C(CCCN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	CHEMBL3577998	121236	0	None	-31	2	Mouse	6.8	pKi	=	6.8	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL	977	13	10	10	-0.4	C[C@@H]1NC(=O)C(CCCN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	44577092	178621	0	None	-144	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	548	10	2	5	4.6	CNCC(=O)N[C@H](c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2OC)CC1)C(C)C	10.1016/j.bmc.2008.03.072
	CHEMBL467586	178621	0	None	-144	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	548	10	2	5	4.6	CNCC(=O)N[C@H](c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2OC)CC1)C(C)C	10.1016/j.bmc.2008.03.072
	CHEMBL427629	213334	0	None	-7	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC1=O	10.1021/jm030119t
	24873537	146036	0	None	-138	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity at human MC3 receptorBinding affinity at human MC3 receptor	ChEMBL	538	6	1	5	4.8	Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](N)C(C)C)c1	10.1016/j.bmcl.2007.09.079
	CHEMBL391902	146036	0	None	-138	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity at human MC3 receptorBinding affinity at human MC3 receptor	ChEMBL	538	6	1	5	4.8	Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](N)C(C)C)c1	10.1016/j.bmcl.2007.09.079
	44400661	124313	0	None	-512	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	620	11	2	5	6.1	O=C(N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)c1ccccc1	10.1016/j.bmcl.2005.03.053
	CHEMBL363641	124313	0	None	-512	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	620	11	2	5	6.1	O=C(N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)c1ccccc1	10.1016/j.bmcl.2005.03.053
	70693083	76900	0	None	-6	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1996	61	24	26	-1.3	CCCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	91929813	76900	0	None	-6	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1996	61	24	26	-1.3	CCCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	CHEMBL2070253	76900	0	None	-6	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1996	61	24	26	-1.3	CCCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	44434636	89271	0	None	-3	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	469	12	3	3	5.6	NCCCCN(Cc1ccccc1)C(=O)CCCc1c(Cc2ccc(O)cc2)[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL236841	89271	0	None	-3	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	469	12	3	3	5.6	NCCCCN(Cc1ccccc1)C(=O)CCCc1c(Cc2ccc(O)cc2)[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	9946241	89403	0	None	-3	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	347	5	2	2	3.1	NCCN(C(=O)Cc1c[nH]c2ccccc12)C1CCc2ccccc2C1	10.1016/j.bmc.2007.06.003
	CHEMBL237079	89403	0	None	-3	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	347	5	2	2	3.1	NCCN(C(=O)Cc1c[nH]c2ccccc12)C1CCc2ccccc2C1	10.1016/j.bmc.2007.06.003
	44434782	89998	0	None	-5	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	511	10	2	2	7.5	NC1CCC(CC2CCC(N(C/C=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL238144	89998	0	None	-5	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	511	10	2	2	7.5	NC1CCC(CC2CCC(N(C/C=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434693	167323	0	None	-7	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	559	12	2	4	7.4	CCOc1cc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)ccc1OC	10.1016/j.bmc.2007.06.003
	CHEMBL429451	167323	0	None	-7	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	559	12	2	4	7.4	CCOc1cc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)ccc1OC	10.1016/j.bmc.2007.06.003
	10211466	168876	0	None	-213	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cell	ChEMBL	633	12	2	5	5.1	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)CC2(C)NCc3ccccc32)CC1	10.1016/j.bmcl.2005.10.103
	CHEMBL438432	168876	0	None	-213	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cell	ChEMBL	633	12	2	5	5.1	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)CC2(C)NCc3ccccc32)CC1	10.1016/j.bmcl.2005.10.103
	4189	206899	96	None	-54	34	Human	4.8	pKi	=	4.8	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL1559	206899	96	None	-54	34	Human	4.8	pKi	=	4.8	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL91	206899	96	None	-54	34	Human	4.8	pKi	=	4.8	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	44409257	140561	0	None	-67	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	690	15	7	6	1.6	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.12.005
	CHEMBL381357	140561	0	None	-67	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	690	15	7	6	1.6	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.12.005
	25133210	169433	0	None	-13	3	Human	6.8	pKi	=	6.8	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	615	11	3	5	3.0	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@@H]1CCCN1	10.1021/jm800525p
	CHEMBL442829	169433	0	None	-13	3	Human	6.8	pKi	=	6.8	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	615	11	3	5	3.0	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@@H]1CCCN1	10.1021/jm800525p
	CHEMBL427666	213341	0	None	-60	4	Human	6.8	pKi	=	6.8	Binding	Inhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cellsInhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cells	ChEMBL		None	None	None		CSC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CSC)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(N)=O	10.1021/jm0501432
	CHEMBL2221249	209420	0	None	1	3	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL		None	None	None		CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O	nan
	168273045	190230	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	2905	62	33	37	-5.8	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5175392	190230	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	2905	62	33	37	-5.8	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	44415920	80342	0	None	-13	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	644	12	4	6	1.2	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)N2CCNCC2)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL214410	80342	0	None	-13	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	644	12	4	6	1.2	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)N2CCNCC2)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	44322959	156051	0	None	-8	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	727	21	9	7	0.6	CCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL406276	156051	0	None	-8	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	727	21	9	7	0.6	CCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	25132864	172578	0	None	-12	3	Human	6.8	pKi	=	6.8	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	590	12	2	5	2.8	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)COC	10.1021/jm800525p
	CHEMBL449050	172578	0	None	-12	3	Human	6.8	pKi	=	6.8	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	590	12	2	5	2.8	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)COC	10.1021/jm800525p
	25058412	189416	0	None	-208	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	534	10	3	5	3.8	CC(C)CC(O)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CCN)CC1	10.1016/j.bmcl.2008.07.076
	CHEMBL513404	189416	0	None	-208	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	534	10	3	5	3.8	CC(C)CC(O)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CCN)CC1	10.1016/j.bmcl.2008.07.076
	44434587	89409	0	None	1	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	391	6	2	3	3.9	NCCN(C(=O)[C@H](N)Cc1ccc(Cl)cc1)C1CCC2(CCCCC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL237094	89409	0	None	1	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	391	6	2	3	3.9	NCCN(C(=O)[C@H](N)Cc1ccc(Cl)cc1)C1CCC2(CCCCC2)CC1	10.1016/j.bmc.2007.06.003
	44434848	88939	0	None	-11	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	461	9	2	2	6.3	NCc1cccc(CN(Cc2ccc3ccccc3c2)C(=O)CCCc2c[nH]c3ccccc23)c1	10.1016/j.bmc.2007.06.003
	CHEMBL236443	88939	0	None	-11	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	461	9	2	2	6.3	NCc1cccc(CN(Cc2ccc3ccccc3c2)C(=O)CCCc2c[nH]c3ccccc23)c1	10.1016/j.bmc.2007.06.003
	44434690	89277	0	None	-19	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	545	10	2	2	8.1	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL236861	89277	0	None	-19	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	545	10	2	2	8.1	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434713	89567	0	None	-14	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	541	11	2	3	7.5	COc1ccccc1/C=C/CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL237502	89567	0	None	-14	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	541	11	2	3	7.5	COc1ccccc1/C=C/CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	10109225	154648	0	None	-10	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	361	8	2	3	3.2	NCCCN(C/C=C/c1ccccc1)C(=O)C(=O)c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL399624	154648	0	None	-10	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	361	8	2	3	3.2	NCCCN(C/C=C/c1ccccc1)C(=O)C(=O)c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44409240	74405	0	None	-16	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	736	18	8	7	1.3	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O	10.1016/j.bmcl.2005.12.005
	CHEMBL202699	74405	0	None	-16	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	736	18	8	7	1.3	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O	10.1016/j.bmcl.2005.12.005
	44409240	74405	0	None	-16	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	736	18	8	7	1.3	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O	10.1016/j.bmcl.2006.05.087
	CHEMBL202699	74405	0	None	-16	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	736	18	8	7	1.3	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O	10.1016/j.bmcl.2006.05.087
	44409240	74405	0	None	-16	3	Human	5.8	pKi	=	5.8	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	736	18	8	7	1.3	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O	10.1021/jm060384p
	CHEMBL202699	74405	0	None	-16	3	Human	5.8	pKi	=	5.8	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	736	18	8	7	1.3	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O	10.1021/jm060384p
	1016	3720	78	None	-56	35	Human	4.8	pKi	=	4.8	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2561	3720	78	None	-56	35	Human	4.8	pKi	=	4.8	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2733526	3720	78	None	-56	35	Human	4.8	pKi	=	4.8	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	5384	3720	78	None	-56	35	Human	4.8	pKi	=	4.8	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	CHEMBL83	3720	78	None	-56	35	Human	4.8	pKi	=	4.8	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	DB00675	3720	78	None	-56	35	Human	4.8	pKi	=	4.8	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	CHEMBL5075506	214356	0	None	-1348	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	137658158	159693	0	None	-63	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1714	21	22	21	-3.6	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4104465	159693	0	None	-63	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1714	21	22	21	-3.6	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	1323	2669	55	None	-72	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.2c00793
	92432	2669	55	None	-72	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.2c00793
	CHEMBL430239	2669	55	None	-72	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.2c00793
	1323	2669	55	None	-72	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00095
	92432	2669	55	None	-72	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00095
	CHEMBL430239	2669	55	None	-72	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.1c00095
	24180646	148158	0	None	-251	8	Mouse	6.8	pKi	=	6.8	Binding	Binding affinity at mouse MC3RBinding affinity at mouse MC3R	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmcl.2007.07.097
	CHEMBL393576	148158	0	None	-251	8	Mouse	6.8	pKi	=	6.8	Binding	Binding affinity at mouse MC3RBinding affinity at mouse MC3R	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmcl.2007.07.097
	44396002	124748	0	None	-43	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards human melanocortin 3 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligandBinding affinity towards human melanocortin 3 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligand	ChEMBL	587	11	2	6	4.8	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)c1cccnc1	10.1016/j.bmcl.2004.08.055
	CHEMBL364215	124748	0	None	-43	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards human melanocortin 3 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligandBinding affinity towards human melanocortin 3 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligand	ChEMBL	587	11	2	6	4.8	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)c1cccnc1	10.1016/j.bmcl.2004.08.055
	11181804	128481	0	None	-158	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptor	ChEMBL	641	11	3	6	4.8	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2004.06.059
	CHEMBL366706	128481	0	None	-158	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptor	ChEMBL	641	11	3	6	4.8	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2004.06.059
	23661656	169020	0	None	-323	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]NDP-MSH from MC3R receptor in HEK293 cellsDisplacement of [125I]NDP-MSH from MC3R receptor in HEK293 cells	ChEMBL	564	8	1	4	5.3	CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)N2CCCC2=O)CC1	10.1016/j.bmc.2007.05.026
	CHEMBL439560	169020	0	None	-323	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]NDP-MSH from MC3R receptor in HEK293 cellsDisplacement of [125I]NDP-MSH from MC3R receptor in HEK293 cells	ChEMBL	564	8	1	4	5.3	CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)N2CCCC2=O)CC1	10.1016/j.bmc.2007.05.026
	44434661	88484	0	None	-4	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	415	11	2	3	4.4	NCCCCCN(Cc1ccccc1)C(=O)[C@H](N)Cc1ccc(-c2ccccc2)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL235136	88484	0	None	-4	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	415	11	2	3	4.4	NCCCCCN(Cc1ccccc1)C(=O)[C@H](N)Cc1ccc(-c2ccccc2)cc1	10.1016/j.bmc.2007.06.003
	44434603	89884	0	None	-2	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	409	10	2	2	4.9	NCCCN(C/C(Cl)=C/c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237935	89884	0	None	-2	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	409	10	2	2	4.9	NCCCN(C/C(Cl)=C/c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44265496	97020	0	None	-13	4	Human	4.8	pKi	=	4.8	Binding	Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay	ChEMBL	453	9	3	3	3.9	NC(N)=NCCC[C@H](N)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12	10.1016/s0960-894x(02)00088-4
	CHEMBL267020	97020	0	None	-13	4	Human	4.8	pKi	=	4.8	Binding	Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay	ChEMBL	453	9	3	3	3.9	NC(N)=NCCC[C@H](N)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12	10.1016/s0960-894x(02)00088-4
	44409379	76493	0	None	-85	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	757	19	6	5	4.3	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC[C@H](Cc1ccc(Cl)cc1)NC(C)=O)Cc1ccc(F)cc1	10.1016/j.bmcl.2005.12.005
	CHEMBL206018	76493	0	None	-85	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	757	19	6	5	4.3	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC[C@H](Cc1ccc(Cl)cc1)NC(C)=O)Cc1ccc(F)cc1	10.1016/j.bmcl.2005.12.005
	25132525	176701	0	None	-2	3	Human	5.7	pKi	=	5.7	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	518	8	2	4	2.9	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](C(C)C)C1=O	10.1021/jm800525p
	CHEMBL460142	176701	0	None	-2	3	Human	5.7	pKi	=	5.7	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	518	8	2	4	2.9	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](C(C)C)C1=O	10.1021/jm800525p
	168270124	189931	0	None	-14	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2096	33	32	24	-3.6	CCCC[C@@H]1NC(=O)[C@@H]2CSCCCSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5170533	189931	0	None	-14	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2096	33	32	24	-3.6	CCCC[C@@H]1NC(=O)[C@@H]2CSCCCSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL407213	212625	0	None	-44	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL		None	None	None		CC(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O	10.1021/jm010165y
	44577060	188028	0	None	-54	8	Mouse	6.7	pKi	=	6.7	Binding	Binding affinity at mouse MC3RBinding affinity at mouse MC3R	ChEMBL	530	10	1	4	4.8	CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
	CHEMBL497746	188028	0	None	-54	8	Mouse	6.7	pKi	=	6.7	Binding	Binding affinity at mouse MC3RBinding affinity at mouse MC3R	ChEMBL	530	10	1	4	4.8	CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
	137637711	155822	0	None	-74	3	Mouse	6.7	pKi	=	6.7	Binding	Displacement of [125I]-NDP-R-MSH from mouse melanocortin receptor 3 expressed in HEK293 cells after 2 hrs by scintillation counting methodDisplacement of [125I]-NDP-R-MSH from mouse melanocortin receptor 3 expressed in HEK293 cells after 2 hrs by scintillation counting method	ChEMBL	871	11	14	12	-3.9	C[C@@H]1NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC1=O	10.1021/acs.jmedchem.7b00856
	CHEMBL4060087	155822	0	None	-74	3	Mouse	6.7	pKi	=	6.7	Binding	Displacement of [125I]-NDP-R-MSH from mouse melanocortin receptor 3 expressed in HEK293 cells after 2 hrs by scintillation counting methodDisplacement of [125I]-NDP-R-MSH from mouse melanocortin receptor 3 expressed in HEK293 cells after 2 hrs by scintillation counting method	ChEMBL	871	11	14	12	-3.9	C[C@@H]1NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC1=O	10.1021/acs.jmedchem.7b00856
	44577091	178643	0	None	-56	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	532	10	2	5	4.0	CNCC(=O)N[C@H](c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2OC)CC1)C(C)C	10.1016/j.bmc.2008.03.072
	CHEMBL467772	178643	0	None	-56	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	532	10	2	5	4.0	CNCC(=O)N[C@H](c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2OC)CC1)C(C)C	10.1016/j.bmc.2008.03.072
	10408	717	28	None	-23	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.8b00170
	5329	717	28	None	-23	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.8b00170
	9941379	717	28	None	-23	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.8b00170
	CHEMBL2070241	717	28	None	-23	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.8b00170
	DB11653	717	28	None	-23	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.8b00170
	11490658	64913	0	None	-301	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human melanocortin 3 receptorBinding affinity for human melanocortin 3 receptor	ChEMBL	642	10	4	6	4.4	CC(NC1CCCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)CC2NCCc3ccccc32)CC1	10.1016/j.bmcl.2004.10.096
	CHEMBL182277	64913	0	None	-301	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human melanocortin 3 receptorBinding affinity for human melanocortin 3 receptor	ChEMBL	642	10	4	6	4.4	CC(NC1CCCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)CC2NCCc3ccccc32)CC1	10.1016/j.bmcl.2004.10.096
	CHEMBL88185	215873	0	None	-11	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		CS(=O)(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	11296732	143788	0	None	-43	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human melanocortin 3 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligandBinding affinity towards human melanocortin 3 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligand	ChEMBL	539	11	3	6	3.1	NCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2004.08.055
	CHEMBL390130	143788	0	None	-43	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human melanocortin 3 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligandBinding affinity towards human melanocortin 3 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligand	ChEMBL	539	11	3	6	3.1	NCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2004.08.055
	10283036	140218	0	None	-331	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cell	ChEMBL	647	11	2	5	5.2	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2Cc3ccccc3C(C)(C)N2)CC1	10.1016/j.bmcl.2005.10.103
	CHEMBL380540	140218	0	None	-331	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cell	ChEMBL	647	11	2	5	5.2	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2Cc3ccccc3C(C)(C)N2)CC1	10.1016/j.bmcl.2005.10.103
	11296732	143788	0	None	-43	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [125]NDP-MSH from human MC3receptor expressed in HEK293 cellsDisplacement of [125]NDP-MSH from human MC3receptor expressed in HEK293 cells	ChEMBL	539	11	3	6	3.1	NCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1021/jm049278i
	CHEMBL390130	143788	0	None	-43	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [125]NDP-MSH from human MC3receptor expressed in HEK293 cellsDisplacement of [125]NDP-MSH from human MC3receptor expressed in HEK293 cells	ChEMBL	539	11	3	6	3.1	NCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1021/jm049278i
	44434772	88568	0	None	-21	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	6.7	C=C(Br)CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL235582	88568	0	None	-21	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	6.7	C=C(Br)CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434621	146280	0	None	-6	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	561	9	1	5	6.4	COc1ccc2c(c1)c(CC(=O)N(CCCCN)C13CC4CC(CC(C4)C1)C3)c(C)n2C(=O)c1ccc(Cl)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL392094	146280	0	None	-6	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	561	9	1	5	6.4	COc1ccc2c(c1)c(CC(=O)N(CCCCN)C13CC4CC(CC(C4)C1)C3)c(C)n2C(=O)c1ccc(Cl)cc1	10.1016/j.bmc.2007.06.003
	9969456	147592	0	None	-11	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	371	7	2	2	4.7	NCCCCN(Cc1ccc2ccccc2c1)C(=O)c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL393125	147592	0	None	-11	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	371	7	2	2	4.7	NCCCCN(Cc1ccc2ccccc2c1)C(=O)c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434845	147878	0	None	-12	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	527	10	4	2	6.5	N=C(N)NC1CCC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL393350	147878	0	None	-12	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	527	10	4	2	6.5	N=C(N)NC1CCC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	71454518	79121	0	None	-12	4	Human	4.7	pKi	=	4.7	Binding	Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay	ChEMBL	456	10	4	3	3.3	NC(N)=NCCC[C@H](N)C(=O)N(CCc1c[nH]c2ccccc12)Cc1ccc2ccccc2c1	10.1016/s0960-894x(02)00088-4
	CHEMBL2113315	79121	0	None	-12	4	Human	4.7	pKi	=	4.7	Binding	Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay	ChEMBL	456	10	4	3	3.3	NC(N)=NCCC[C@H](N)C(=O)N(CCc1c[nH]c2ccccc12)Cc1ccc2ccccc2c1	10.1016/s0960-894x(02)00088-4
	11845444	80038	0	None	-11	3	Human	4.7	pKi	=	4.7	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	678	15	5	6	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL213026	80038	0	None	-11	3	Human	4.7	pKi	=	4.7	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	678	15	5	6	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N	10.1021/jm060384p
	137631599	156502	0	None	-288	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1694	20	20	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4067967	156502	0	None	-288	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1694	20	20	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	11847001	80199	0	None	-138	3	Human	5.7	pKi	=	5.7	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	652	15	5	6	2.6	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL213747	80199	0	None	-138	3	Human	5.7	pKi	=	5.7	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	652	15	5	6	2.6	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N	10.1021/jm060384p
	156010247	177048	0	None	-11	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in CHO-K1 cell membranes incubated for 3 hrs by top-count beta countingDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in CHO-K1 cell membranes incubated for 3 hrs by top-count beta counting	ChEMBL	2913	40	44	46	-16.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc4cnc[nH]4)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N2)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@H](C(=O)O)[C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC3=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC1=O	10.1021/acs.jmedchem.0c00485
	CHEMBL4633001	177048	0	None	-11	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in CHO-K1 cell membranes incubated for 3 hrs by top-count beta countingDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in CHO-K1 cell membranes incubated for 3 hrs by top-count beta counting	ChEMBL	2913	40	44	46	-16.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc4cnc[nH]4)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N2)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@H](C(=O)O)[C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC3=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC1=O	10.1021/acs.jmedchem.0c00485
	10408	717	28	None	-23	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.2c00793
	5329	717	28	None	-23	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.2c00793
	9941379	717	28	None	-23	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.2c00793
	CHEMBL2070241	717	28	None	-23	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.2c00793
	DB11653	717	28	None	-23	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.2c00793
	10408	717	28	None	-23	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.1c00095
	5329	717	28	None	-23	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.1c00095
	9941379	717	28	None	-23	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.1c00095
	CHEMBL2070241	717	28	None	-23	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.1c00095
	DB11653	717	28	None	-23	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/acs.jmedchem.1c00095
	57646411	76892	0	None	-5	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1739	49	24	20	-1.7	CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	CHEMBL2070245	76892	0	None	-5	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1739	49	24	20	-1.7	CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	57646441	76891	0	None	-20	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1706	46	22	20	-1.4	CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	CHEMBL2070243	76891	0	None	-20	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1706	46	22	20	-1.4	CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	CHEMBL408843	212712	0	None	-6	3	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL		None	None	None		CC(=O)N[C@@H]1CSSC[C@@H](C(N)=O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm010165y
	CHEMBL2370533	209845	0	None	-9	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL		None	None	None		CC(=O)N[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(=O)O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm010165y
	CHEMBL331259	211338	0	None	-70	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O	10.1021/jm010165y
	44323029	207158	0	None	-5	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	795	20	10	7	1.5	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL92481	207158	0	None	-5	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	795	20	10	7	1.5	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	168284733	191600	0	None	-6	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2054	33	32	24	-4.1	CCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5195641	191600	0	None	-6	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2054	33	32	24	-4.1	CCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL3578000	211731	0	None	-50	2	Mouse	6.7	pKi	=	6.7	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CCCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	44577062	193350	0	None	-48	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	518	9	2	4	4.6	CNCC(=O)N[C@H](c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1)C(C)C	10.1016/j.bmc.2008.03.072
	CHEMBL525177	193350	0	None	-48	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	518	9	2	4	4.6	CNCC(=O)N[C@H](c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1)C(C)C	10.1016/j.bmc.2008.03.072
	11296600	122917	0	None	-309	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptor	ChEMBL	628	9	4	6	3.8	CC(NC1CCCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2004.06.059
	CHEMBL360716	122917	0	None	-309	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptor	ChEMBL	628	9	4	6	3.8	CC(NC1CCCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2004.06.059
	10180932	89378	0	None	-3	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	427	11	2	2	5.8	NCCCCCN(Cc1ccc2ccccc2c1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237051	89378	0	None	-3	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	427	11	2	2	5.8	NCCCCCN(Cc1ccc2ccccc2c1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434695	89397	0	None	-8	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	503	9	2	2	7.1	NC1CCC(CC2CCC(N(Cc3ccccc3F)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL237070	89397	0	None	-8	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	503	9	2	2	7.1	NC1CCC(CC2CCC(N(Cc3ccccc3F)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434766	154690	0	None	-10	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	510	9	2	3	6.9	N#Cc1ccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL399810	154690	0	None	-10	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	510	9	2	3	6.9	N#Cc1ccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	25128749	178446	0	None	-25	3	Human	6.7	pKi	=	6.7	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	560	10	2	4	3.2	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(C)=O	10.1021/jm800525p
	CHEMBL466380	178446	0	None	-25	3	Human	6.7	pKi	=	6.7	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	560	10	2	4	3.2	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(C)=O	10.1021/jm800525p
	44416152	81069	0	None	-38	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	560	11	3	4	2.4	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)CCc2ccc(F)cc2)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL215576	81069	0	None	-38	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	560	11	3	4	2.4	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)CCc2ccc(F)cc2)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	25129109	188678	0	None	-34	3	Human	6.7	pKi	=	6.7	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	603	12	3	5	2.8	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@H](C)NC	10.1021/jm800525p
	CHEMBL504349	188678	0	None	-34	3	Human	6.7	pKi	=	6.7	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	603	12	3	5	2.8	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@H](C)NC	10.1021/jm800525p
	44322812	112355	0	None	-4	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	711	19	10	7	0.0	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)C1CC1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL329586	112355	0	None	-4	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	711	19	10	7	0.0	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)C1CC1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	44434584	151918	0	None	1	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	394	6	1	3	4.9	NCCN(C(=O)COc1ccc2ccccc2c1)C1CCC2(CCCCC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL396638	151918	0	None	1	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	394	6	1	3	4.9	NCCN(C(=O)COc1ccc2ccccc2c1)C1CCC2(CCCCC2)CC1	10.1016/j.bmc.2007.06.003
	44434772	88568	0	None	-21	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	6.7	C=C(Br)CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL235582	88568	0	None	-21	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	6.7	C=C(Br)CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434690	89277	0	None	-19	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	545	10	2	2	8.1	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL236861	89277	0	None	-19	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	545	10	2	2	8.1	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	10291369	168898	0	None	-3	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	347	8	2	2	3.6	NCCCN(C/C=C/c1ccccc1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL438672	168898	0	None	-3	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	347	8	2	2	3.6	NCCCN(C/C=C/c1ccccc1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	2726	916	68	None	-186	73	Human	4.7	pKi	=	4.7	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	621	916	68	None	-186	73	Human	4.7	pKi	=	4.7	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	83	916	68	None	-186	73	Human	4.7	pKi	=	4.7	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	CHEMBL71	916	68	None	-186	73	Human	4.7	pKi	=	4.7	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	DB00477	916	68	None	-186	73	Human	4.7	pKi	=	4.7	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	25132867	172474	0	None	-6	3	Human	6.7	pKi	=	6.7	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	623	11	2	5	3.9	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)c1ccccn1	10.1021/jm800525p
	CHEMBL448337	172474	0	None	-6	3	Human	6.7	pKi	=	6.7	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	623	11	2	5	3.9	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)c1ccccn1	10.1021/jm800525p
	44413932	137521	0	None	-4	3	Human	6.7	pKi	=	6.7	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	570	12	5	5	3.1	N=C(N)NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1	10.1021/jm060384p
	CHEMBL375440	137521	0	None	-4	3	Human	6.7	pKi	=	6.7	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	570	12	5	5	3.1	N=C(N)NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1	10.1021/jm060384p
	CHEMBL2070244	209161	0	None	-21	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(C)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	44577093	178622	0	None	-275	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	548	9	2	5	4.7	COc1cc(Cl)ccc1C[C@@H](C)C(=O)N1CCN(c2ccc(Cl)cc2[C@@H](NC(=O)[C@@H](C)N)C(C)C)CC1	10.1016/j.bmc.2008.03.072
	CHEMBL467587	178622	0	None	-275	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	548	9	2	5	4.7	COc1cc(Cl)ccc1C[C@@H](C)C(=O)N1CCN(c2ccc(Cl)cc2[C@@H](NC(=O)[C@@H](C)N)C(C)C)CC1	10.1016/j.bmc.2008.03.072
	11341045	66136	0	None	-123	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human melanocortin 3 receptorBinding affinity for human melanocortin 3 receptor	ChEMBL	501	6	3	3	5.0	O=C(NCCc1ccc(Cl)cc1Cl)c1ccc(N/C(=N/C2CCCCC2)N2CCNCC2)cc1	10.1021/jm0400496
	CHEMBL184275	66136	0	None	-123	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human melanocortin 3 receptorBinding affinity for human melanocortin 3 receptor	ChEMBL	501	6	3	3	5.0	O=C(NCCc1ccc(Cl)cc1Cl)c1ccc(N/C(=N/C2CCCCC2)N2CCNCC2)cc1	10.1021/jm0400496
	44434760	88488	0	None	-7	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	519	9	2	2	7.6	NC1CCC(CC2CCC(N(Cc3ccccc3Cl)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL235140	88488	0	None	-7	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	519	9	2	2	7.6	NC1CCC(CC2CCC(N(Cc3ccccc3Cl)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434691	89396	0	None	-6	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	545	11	2	4	7.0	COc1ccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	CHEMBL237069	89396	0	None	-6	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	545	11	2	4	7.0	COc1ccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	44434701	89472	0	None	-16	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	499	9	2	2	7.3	Cc1cccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)c1	10.1016/j.bmc.2007.06.003
	CHEMBL237291	89472	0	None	-16	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	499	9	2	2	7.3	Cc1cccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)c1	10.1016/j.bmc.2007.06.003
	44434778	89714	0	None	-27	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	544	9	1	3	7.8	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)COc3ccc4ccccc4c3)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL237702	89714	0	None	-27	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	544	9	1	3	7.8	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)COc3ccc4ccccc4c3)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434655	89993	0	None	-6	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	417	12	2	2	5.6	C/C(=C/c1ccccc1)CN(CCCCCN)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL238135	89993	0	None	-6	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	417	12	2	2	5.6	C/C(=C/c1ccccc1)CN(CCCCCN)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434855	90001	0	None	-10	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	7.5	CC1CC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	CHEMBL238154	90001	0	None	-10	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	7.5	CC1CC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	168283984	191222	0	None	-3	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	2937	64	35	39	-7.9	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5190172	191222	0	None	-3	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	2937	64	35	39	-7.9	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	44415956	141931	0	None	-17	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	531	13	6	5	0.7	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)Cc1ccccc1	10.1016/j.bmcl.2006.05.087
	CHEMBL387246	141931	0	None	-17	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	531	13	6	5	0.7	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)Cc1ccccc1	10.1016/j.bmcl.2006.05.087
	44415956	141931	0	None	-17	3	Human	4.7	pKi	=	4.7	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	531	13	6	5	0.7	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)Cc1ccccc1	10.1021/jm060384p
	CHEMBL387246	141931	0	None	-17	3	Human	4.7	pKi	=	4.7	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	531	13	6	5	0.7	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)Cc1ccccc1	10.1021/jm060384p
	44409103	140098	0	None	-2	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	628	15	5	6	2.4	CC(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccccc2)C[C@@H]1CCCN=C(N)N	10.1016/j.bmcl.2005.12.005
	CHEMBL380120	140098	0	None	-2	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	628	15	5	6	2.4	CC(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccccc2)C[C@@H]1CCCN=C(N)N	10.1016/j.bmcl.2005.12.005
	168283616	191215	0	None	-11	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2110	33	32	25	-4.5	CCCC[C@@H]1NC(=O)[C@@H]2CSCC(=O)CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5190042	191215	0	None	-11	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2110	33	32	25	-4.5	CCCC[C@@H]1NC(=O)[C@@H]2CSCC(=O)CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	44323015	111406	0	None	-3	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	731	20	9	8	-0.2	CSCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL327450	111406	0	None	-3	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	731	20	9	8	-0.2	CSCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	23635107	91529	0	None	-81	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]NDP-MSH from human MC3RDisplacement of [125I]NDP-MSH from human MC3R	ChEMBL	516	9	2	4	4.3	CNCC(=O)N[C@H](c1cc(C)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2F)CC1)C(C)C	10.1021/jm070806a
	CHEMBL240571	91529	0	None	-81	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]NDP-MSH from human MC3RDisplacement of [125I]NDP-MSH from human MC3R	ChEMBL	516	9	2	4	4.3	CNCC(=O)N[C@H](c1cc(C)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2F)CC1)C(C)C	10.1021/jm070806a
	23635107	91529	0	None	-81	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	516	9	2	4	4.3	CNCC(=O)N[C@H](c1cc(C)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2F)CC1)C(C)C	10.1016/j.bmc.2008.03.072
	CHEMBL240571	91529	0	None	-81	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	516	9	2	4	4.3	CNCC(=O)N[C@H](c1cc(C)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2F)CC1)C(C)C	10.1016/j.bmc.2008.03.072
	11477853	66864	0	None	-63	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human melanocortin 3 receptorBinding affinity for human melanocortin 3 receptor	ChEMBL	515	7	3	3	5.2	CNC1CCN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)C1	10.1021/jm0400496
	CHEMBL186439	66864	0	None	-63	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human melanocortin 3 receptorBinding affinity for human melanocortin 3 receptor	ChEMBL	515	7	3	3	5.2	CNC1CCN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)C1	10.1021/jm0400496
	44562414	176793	0	None	-95	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	532	10	2	5	3.9	CC(C)CC(=O)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CCN)CC1	10.1016/j.bmcl.2008.07.076
	CHEMBL460942	176793	0	None	-95	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	532	10	2	5	3.9	CC(C)CC(=O)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CCN)CC1	10.1016/j.bmcl.2008.07.076
	1338	3778	43	None	-75	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptor	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2004.06.059
	9938402	3778	43	None	-75	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptor	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2004.06.059
	CHEMBL339053	3778	43	None	-75	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptor	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2004.06.059
	44394079	126739	0	None	-85	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptor	ChEMBL	653	11	3	5	4.9	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2ccccc2F)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2004.06.059
	CHEMBL365278	126739	0	None	-85	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptor	ChEMBL	653	11	3	5	4.9	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2CNCCc2ccccc2F)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2004.06.059
	9867330	97813	0	None	-100	2	Human	5.6	pKi	=	5.6	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	429	6	1	5	3.7	N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(Cn2cncn2)(C2CCCCC2)CC1	10.1016/j.bmcl.2007.11.109
	CHEMBL272099	97813	0	None	-100	2	Human	5.6	pKi	=	5.6	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	429	6	1	5	3.7	N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(Cn2cncn2)(C2CCCCC2)CC1	10.1016/j.bmcl.2007.11.109
	44397283	67136	0	None	-181	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells	ChEMBL	591	11	3	5	4.1	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(C2(CNCc3ccccc3F)CCCCC2)CC1	10.1016/j.bmcl.2005.05.017
	CHEMBL187659	67136	0	None	-181	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells	ChEMBL	591	11	3	5	4.1	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(C2(CNCc3ccccc3F)CCCCC2)CC1	10.1016/j.bmcl.2005.05.017
	44434692	88496	0	None	-12	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	651	13	3	5	8.3	COc1ccc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	CHEMBL235176	88496	0	None	-12	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	651	13	3	5	8.3	COc1ccc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	44434847	88928	0	None	-6	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	553	11	4	2	7.0	N=C(N)NC1CCC(CC2CCC(N(C/C=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL236442	88928	0	None	-6	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	553	11	4	2	7.0	N=C(N)NC1CCC(CC2CCC(N(C/C=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434778	89714	0	None	-27	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	544	9	1	3	7.8	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)COc3ccc4ccccc4c3)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL237702	89714	0	None	-27	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	544	9	1	3	7.8	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)COc3ccc4ccccc4c3)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434765	161747	0	None	-20	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	643	11	3	3	9.1	NC1CCC(CC2CCC(N(Cc3c(F)cccc3Cl)C(=O)CCCc3c(Cc4ccc(O)cc4)[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL413982	161747	0	None	-20	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	643	11	3	3	9.1	NC1CCC(CC2CCC(N(Cc3c(F)cccc3Cl)C(=O)CCCc3c(Cc4ccc(O)cc4)[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	137655905	158804	0	None	-64	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1666	20	22	21	-3.9	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4094606	158804	0	None	-64	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1666	20	22	21	-3.9	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	16007263	79767	0	None	-41	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	557	11	4	5	1.2	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccccc2)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL211975	79767	0	None	-41	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	557	11	4	5	1.2	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccccc2)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	24848995	117921	0	None	11	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptor at 10 uMDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptor at 10 uM	ChEMBL	583	8	2	7	3.1	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2Cn2cncn2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2004.06.059
	CHEMBL340355	117921	0	None	11	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptor at 10 uMDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptor at 10 uM	ChEMBL	583	8	2	7	3.1	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2Cn2cncn2)CC1)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2004.06.059
	CHEMBL263878	210575	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@@H]1CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC1=O	10.1021/jm030119t
	44347331	16295	0	None	-181	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	794	10	9	7	1.3	CCC1CC(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(N)=O)CCCCNC1=O	10.1021/jm010165y
	CHEMBL122773	16295	0	None	-181	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	794	10	9	7	1.3	CCC1CC(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(N)=O)CCCCNC1=O	10.1021/jm010165y
	24180646	148158	0	None	-338	8	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at rat MC3RBinding affinity at rat MC3R	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmcl.2007.07.097
	CHEMBL393576	148158	0	None	-338	8	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at rat MC3RBinding affinity at rat MC3R	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmcl.2007.07.097
	11237444	127439	0	None	-457	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human melanocortin 3 receptorBinding affinity for human melanocortin 3 receptor	ChEMBL	503	8	4	3	5.4	CC(C)(N)C/N=C(\Nc1ccc(C(=O)NCCc2ccc(Cl)cc2Cl)cc1)NC1CCCCC1	10.1021/jm0400496
	CHEMBL366042	127439	0	None	-457	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human melanocortin 3 receptorBinding affinity for human melanocortin 3 receptor	ChEMBL	503	8	4	3	5.4	CC(C)(N)C/N=C(\Nc1ccc(C(=O)NCCc2ccc(Cl)cc2Cl)cc1)NC1CCCCC1	10.1021/jm0400496
	44397304	126800	0	None	-199	4	Human	5.6	pKi	=	5.6	Binding	Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells	ChEMBL	579	11	3	6	4.1	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(C2(CNCc3cccs3)CCCCC2)CC1	10.1016/j.bmcl.2005.05.017
	CHEMBL365465	126800	0	None	-199	4	Human	5.6	pKi	=	5.6	Binding	Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells Inhibition of [125I]NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells	ChEMBL	579	11	3	6	4.1	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(C2(CNCc3cccs3)CCCCC2)CC1	10.1016/j.bmcl.2005.05.017
	44434764	88531	0	None	-11	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	551	10	2	2	7.8	NC1CCC(CC2CCC(N(CCc3c(F)cccc3Cl)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL235358	88531	0	None	-11	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	551	10	2	2	7.8	NC1CCC(CC2CCC(N(CCc3c(F)cccc3Cl)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434884	88582	0	None	-8	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	417	9	2	2	5.3	NCC1CCCC(CN(Cc2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)C1	10.1016/j.bmc.2007.06.003
	CHEMBL235617	88582	0	None	-8	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	417	9	2	2	5.3	NCC1CCCC(CN(Cc2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)C1	10.1016/j.bmc.2007.06.003
	44434689	89146	0	None	-19	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	431	14	2	2	5.9	NCCCCCCCCN(C/C=C/c1ccccc1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL236649	89146	0	None	-19	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	431	14	2	2	5.9	NCCCCCCCCN(C/C=C/c1ccccc1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	10291370	145941	0	None	-28	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	347	7	2	2	4.1	C/C(=C\c1ccccc1)CN(CCCN)C(=O)c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL391823	145941	0	None	-28	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	347	7	2	2	4.1	C/C(=C\c1ccccc1)CN(CCCN)C(=O)c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434762	152986	0	None	-13	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	579	11	2	4	7.7	COc1cc(Cl)c(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	CHEMBL397550	152986	0	None	-13	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	579	11	2	4	7.7	COc1cc(Cl)c(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	44409140	141261	0	None	-10	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	675	16	6	5	3.5	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC[C@@H]1Cc2ccccc2CN1)Cc1ccccc1	10.1016/j.bmcl.2005.12.005
	CHEMBL383256	141261	0	None	-10	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	675	16	6	5	3.5	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC[C@@H]1Cc2ccccc2CN1)Cc1ccccc1	10.1016/j.bmcl.2005.12.005
	44401386	69495	0	None	-2	2	Human	5.6	pKi	=	5.6	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	593	12	6	4	3.6	N=C(N)NCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)Nc1ccccc1	10.1016/j.bmcl.2005.03.120
	CHEMBL193409	69495	0	None	-2	2	Human	5.6	pKi	=	5.6	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	593	12	6	4	3.6	N=C(N)NCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)Nc1ccccc1	10.1016/j.bmcl.2005.03.120
	137636677	156076	0	None	-50	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1680	20	21	21	-3.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4063111	156076	0	None	-50	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1680	20	21	21	-3.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	137636965	156192	0	None	-23	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1742	21	20	21	-2.9	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4064433	156192	0	None	-23	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1742	21	20	21	-2.9	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	44409337	170437	0	None	-114	3	Human	4.6	pKi	=	4.6	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	721	19	7	6	3.2	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC[C@H](Cc1ccc(O)cc1)NC(C)=O)Cc1ccccc1	10.1016/j.bmcl.2005.12.005
	CHEMBL444883	170437	0	None	-114	3	Human	4.6	pKi	=	4.6	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	721	19	7	6	3.2	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC[C@H](Cc1ccc(O)cc1)NC(C)=O)Cc1ccccc1	10.1016/j.bmcl.2005.12.005
	CHEMBL2370553	209847	0	None	-16	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL		None	None	None		CC(=O)N[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(=O)O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm010165y
	CHEMBL3577995	211729	0	None	-6	2	Mouse	7.6	pKi	=	7.6	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		C[C@@H]1NC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	44401440	70091	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	618	13	5	4	3.9	N=C(N)NCCC[C@H](NC(=O)Cc1ccc2ccccc2c1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	CHEMBL194011	70091	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	618	13	5	4	3.9	N=C(N)NCCC[C@H](NC(=O)Cc1ccc2ccccc2c1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	11341046	66850	0	None	-95	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human melanocortin 3 receptorBinding affinity for human melanocortin 3 receptor	ChEMBL	501	7	4	3	5.0	O=C(NCCc1ccc(Cl)cc1Cl)c1ccc(N/C(=N\C2CCNC2)NC2CCCCC2)cc1	10.1021/jm0400496
	CHEMBL186339	66850	0	None	-95	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human melanocortin 3 receptorBinding affinity for human melanocortin 3 receptor	ChEMBL	501	7	4	3	5.0	O=C(NCCc1ccc(Cl)cc1Cl)c1ccc(N/C(=N\C2CCNC2)NC2CCCCC2)cc1	10.1021/jm0400496
	44562440	179017	0	None	-38	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	534	10	3	5	3.7	CNCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2C(O)CC(C)C)CC1	10.1016/j.bmcl.2008.07.076
	CHEMBL471340	179017	0	None	-38	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	534	10	3	5	3.7	CNCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2C(O)CC(C)C)CC1	10.1016/j.bmcl.2008.07.076
	122178164	121232	0	None	-158	2	Mouse	5.6	pKi	=	5.6	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL	1027	12	10	10	-0.1	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)C(Cc2cccc3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	CHEMBL3577993	121232	0	None	-158	2	Mouse	5.6	pKi	=	5.6	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL	1027	12	10	10	-0.1	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)C(Cc2cccc3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	44434880	88581	0	None	-16	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	477	10	2	2	6.4	NCC1CCCC(CN(C/C(Cl)=C/c2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)C1	10.1016/j.bmc.2007.06.003
	CHEMBL235616	88581	0	None	-16	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	477	10	2	2	6.4	NCC1CCCC(CN(C/C(Cl)=C/c2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)C1	10.1016/j.bmc.2007.06.003
	44434647	89561	0	None	-4	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	421	10	2	2	5.3	NCCCCCN(C(=O)CCCc1c[nH]c2ccccc12)C1C2CC3CC(C2)CC1C3	10.1016/j.bmc.2007.06.003
	CHEMBL237483	89561	0	None	-4	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	421	10	2	2	5.3	NCCCCCN(C(=O)CCCc1c[nH]c2ccccc12)C1C2CC3CC(C2)CC1C3	10.1016/j.bmc.2007.06.003
	44434767	89706	0	None	-17	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	616	11	3	4	8.2	N#Cc1ccc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL237689	89706	0	None	-17	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	616	11	3	4	8.2	N#Cc1ccc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	44434868	149527	0	None	-8	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	635	11	5	4	6.7	NC1CCCC(NC(=O)NC2CCCC(N(Cc3ccccc3)C(=O)CCCc3c(Cc4ccc(O)cc4)[nH]c4ccccc34)C2)C1	10.1016/j.bmc.2007.06.003
	CHEMBL394669	149527	0	None	-8	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	635	11	5	4	6.7	NC1CCCC(NC(=O)NC2CCCC(N(Cc3ccccc3)C(=O)CCCc3c(Cc4ccc(O)cc4)[nH]c4ccccc34)C2)C1	10.1016/j.bmc.2007.06.003
	44434762	152986	0	None	-13	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	579	11	2	4	7.7	COc1cc(Cl)c(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	CHEMBL397550	152986	0	None	-13	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	579	11	2	4	7.7	COc1cc(Cl)c(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	44434768	154691	0	None	-10	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	553	9	2	2	8.3	NC1CCC(CC2CCC(N(Cc3c(Cl)cccc3Cl)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL399811	154691	0	None	-10	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	553	9	2	2	8.3	NC1CCC(CC2CCC(N(Cc3c(Cl)cccc3Cl)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	11308054	133591	0	None	-8	2	Human	6.6	pKi	=	6.6	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	618	13	5	4	3.9	N=C(N)NCCC[C@H](NC(=O)Cc1cccc2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	CHEMBL371365	133591	0	None	-8	2	Human	6.6	pKi	=	6.6	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	618	13	5	4	3.9	N=C(N)NCCC[C@H](NC(=O)Cc1cccc2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	44413914	139493	0	None	-40	3	Human	7.6	pKi	=	7.6	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	652	15	5	6	2.6	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL379508	139493	0	None	-40	3	Human	7.6	pKi	=	7.6	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	652	15	5	6	2.6	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	168289457	191356	0	None	-16	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2158	33	32	24	-2.3	CCCC[C@@H]1NC(=O)[C@@H]2CSCc3ccccc3CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5192329	191356	0	None	-16	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2158	33	32	24	-2.3	CCCC[C@@H]1NC(=O)[C@@H]2CSCc3ccccc3CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	44456222	97897	0	None	-223	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to MC3RBinding affinity to MC3R	ChEMBL	637	10	1	6	5.0	Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1016/j.bmcl.2007.10.115
	CHEMBL272538	97897	0	None	-223	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to MC3RBinding affinity to MC3R	ChEMBL	637	10	1	6	5.0	Cc1ccc(N2CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1016/j.bmcl.2007.10.115
	44323033	107125	0	None	-8	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	747	19	10	7	0.9	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL316259	107125	0	None	-8	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	747	19	10	7	0.9	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	44434694	88572	0	None	-12	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	665	14	3	5	8.7	CCOc1cc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)ccc1OC	10.1016/j.bmc.2007.06.003
	CHEMBL235589	88572	0	None	-12	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	665	14	3	5	8.7	CCOc1cc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)ccc1OC	10.1016/j.bmc.2007.06.003
	44434761	89138	0	None	-3	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	625	11	3	3	8.9	NC1CCC(CC2CCC(N(Cc3ccccc3Cl)C(=O)CCCc3c(Cc4ccc(O)cc4)[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL236626	89138	0	None	-3	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	625	11	3	3	8.9	NC1CCC(CC2CCC(N(Cc3ccccc3Cl)C(=O)CCCc3c(Cc4ccc(O)cc4)[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434592	89486	0	None	-7	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	399	9	2	2	5.0	NCCCN(Cc1ccc2ccccc2c1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237315	89486	0	None	-7	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	399	9	2	2	5.0	NCCCN(Cc1ccc2ccccc2c1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434682	148580	0	None	-10	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	451	13	2	2	6.1	NCCCCCCN(C/C(Cl)=C/c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL393919	148580	0	None	-10	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	451	13	2	2	6.1	NCCCCCCN(C/C(Cl)=C/c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	25131477	178677	0	None	-42	3	Human	4.6	pKi	=	4.6	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	547	10	2	5	2.2	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCN(C)C)C1=O	10.1021/jm800525p
	CHEMBL468252	178677	0	None	-42	3	Human	4.6	pKi	=	4.6	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	547	10	2	5	2.2	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCN(C)C)C1=O	10.1021/jm800525p
	CHEMBL5075712	214371	0	None	-181	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	57817763	76898	0	None	-338	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1988	59	26	26	-3.2	CCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	70690940	76898	0	None	-338	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1988	59	26	26	-3.2	CCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	91929808	76898	0	None	-338	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1988	59	26	26	-3.2	CCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	CHEMBL2070251	76898	0	None	-338	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1988	59	26	26	-3.2	CCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	23635237	91424	0	None	-45	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]NDP-MSH from human MC3RDisplacement of [125I]NDP-MSH from human MC3R	ChEMBL	498	9	2	4	4.3	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN)C(C)C)c1	10.1021/jm070806a
	CHEMBL240364	91424	0	None	-45	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]NDP-MSH from human MC3RDisplacement of [125I]NDP-MSH from human MC3R	ChEMBL	498	9	2	4	4.3	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN)C(C)C)c1	10.1021/jm070806a
	23635237	91424	0	None	-45	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	498	9	2	4	4.3	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN)C(C)C)c1	10.1016/j.bmc.2008.03.072
	CHEMBL240364	91424	0	None	-45	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	498	9	2	4	4.3	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN)C(C)C)c1	10.1016/j.bmc.2008.03.072
	44401513	69133	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	612	13	5	6	2.5	N=C(N)NCCC[C@H](NC(=O)Cc1ccc2c(c1)OCO2)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	CHEMBL192450	69133	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	612	13	5	6	2.5	N=C(N)NCCC[C@H](NC(=O)Cc1ccc2c(c1)OCO2)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	44434581	167027	0	None	1	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	395	7	2	2	5.2	NCCN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC2(CCCCC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL428903	167027	0	None	1	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	395	7	2	2	5.2	NCCN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC2(CCCCC2)CC1	10.1016/j.bmc.2007.06.003
	44434772	88568	0	None	-21	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	6.7	C=C(Br)CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL235582	88568	0	None	-21	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	6.7	C=C(Br)CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434683	89274	0	None	-7	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	405	10	3	3	4.9	C/C(=C\c1ccccc1)CN(CCCCCCN)C(=O)c1cc2cc(O)ccc2[nH]1	10.1016/j.bmc.2007.06.003
	CHEMBL236847	89274	0	None	-7	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	405	10	3	3	4.9	C/C(=C\c1ccccc1)CN(CCCCCCN)C(=O)c1cc2cc(O)ccc2[nH]1	10.1016/j.bmc.2007.06.003
	44434769	89710	0	None	-16	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	659	11	3	3	9.6	NC1CCC(CC2CCC(N(Cc3c(Cl)cccc3Cl)C(=O)CCCc3c(Cc4ccc(O)cc4)[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL237698	89710	0	None	-16	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	659	11	3	3	9.6	NC1CCC(CC2CCC(N(Cc3c(Cl)cccc3Cl)C(=O)CCCc3c(Cc4ccc(O)cc4)[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434650	89870	0	None	-7	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	389	11	2	2	4.8	NCCCCCN(C/C=C/c1ccccc1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237910	89870	0	None	-7	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	389	11	2	2	4.8	NCCCCCN(C/C=C/c1ccccc1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434651	89871	0	None	-8	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	495	13	3	3	6.1	NCCCCCN(C/C=C\c1ccccc1)C(=O)CCc1c(Cc2ccc(O)cc2)[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237911	89871	0	None	-8	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	495	13	3	3	6.1	NCCCCCN(C/C=C\c1ccccc1)C(=O)CCc1c(Cc2ccc(O)cc2)[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434654	89992	0	None	-10	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	421	10	2	2	5.4	NCCCCCN(C/C(Cl)=C\c1ccccc1)C(=O)/C=C/c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL238134	89992	0	None	-10	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	421	10	2	2	5.4	NCCCCCN(C/C(Cl)=C\c1ccccc1)C(=O)/C=C/c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434863	148120	0	None	-10	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	417	9	2	2	5.3	NCC1CCC(CN(Cc2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL393552	148120	0	None	-10	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	417	9	2	2	5.3	NCC1CCC(CN(Cc2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2007.06.003
	168282596	190882	0	None	-2	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	2990	66	33	37	-3.8	CC(C)C[C@@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)CSSC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC1=O	10.1021/acs.jmedchem.2c00786
	CHEMBL5185132	190882	0	None	-2	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	2990	66	33	37	-3.8	CC(C)C[C@@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)CSSC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC1=O	10.1021/acs.jmedchem.2c00786
	168281389	190898	0	None	-7	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2149	33	33	26	-5.2	CCCC[C@@H]1NC(=O)[C@@H]2CSC3=C(SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2)C(=O)NC3=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5185405	190898	0	None	-7	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2149	33	33	26	-5.2	CCCC[C@@H]1NC(=O)[C@@H]2CSC3=C(SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2)C(=O)NC3=O	10.1021/acs.jmedchem.2c00793
	44323233	106689	0	None	-4	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsBinding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	901	11	12	9	0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)c2ccccc2C(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL314401	106689	0	None	-4	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsBinding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	901	11	12	9	0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)c2ccccc2C(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	44322986	106070	0	None	-7	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	713	19	9	7	0.1	CC(C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL313377	106070	0	None	-7	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	713	19	9	7	0.1	CC(C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	11249545	66174	0	None	-478	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human melanocortin 3 receptorBinding affinity for human melanocortin 3 receptor	ChEMBL	529	6	3	3	5.6	C[C@H]1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)[C@H](C)CN1	10.1021/jm0400496
	CHEMBL184432	66174	0	None	-478	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human melanocortin 3 receptorBinding affinity for human melanocortin 3 receptor	ChEMBL	529	6	3	3	5.6	C[C@H]1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)[C@H](C)CN1	10.1021/jm0400496
	11364326	66656	0	None	-134	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human melanocortin 3 receptorBinding affinity for human melanocortin 3 receptor	ChEMBL	515	6	3	3	5.2	C[C@H]1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CCN1	10.1021/jm0400496
	CHEMBL185455	66656	0	None	-134	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human melanocortin 3 receptorBinding affinity for human melanocortin 3 receptor	ChEMBL	515	6	3	3	5.2	C[C@H]1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CCN1	10.1021/jm0400496
	24740653	88563	0	None	-758	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]NDPMSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC3R expressed in HEK293 cells	ChEMBL	540	11	1	4	5.3	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@H](CC(C)C)NC(=O)CCN(C)C)c1	10.1021/jm701137s
	CHEMBL235556	88563	0	None	-758	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]NDPMSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC3R expressed in HEK293 cells	ChEMBL	540	11	1	4	5.3	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@H](CC(C)C)NC(=O)CCN(C)C)c1	10.1021/jm701137s
	44265707	10152	0	None	-4	4	Human	4.6	pKi	=	4.6	Binding	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptor	ChEMBL	354	10	3	4	2.1	C=CCOC(=O)[C@H](CCCN=C(N)N)NCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00089-6
	CHEMBL1159701	10152	0	None	-4	4	Human	4.6	pKi	=	4.6	Binding	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptor	ChEMBL	354	10	3	4	2.1	C=CCOC(=O)[C@H](CCCN=C(N)N)NCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00089-6
	44434759	88487	0	None	-7	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	486	9	2	3	6.4	NC1CCC(CC2CCC(N(Cc3ccncc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL235139	88487	0	None	-7	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	486	9	2	3	6.4	NC1CCC(CC2CCC(N(Cc3ccncc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434688	89144	0	None	-8	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	405	13	2	2	5.4	NCCCCCCCN(Cc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL236640	89144	0	None	-8	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	405	13	2	2	5.4	NCCCCCCCN(Cc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	168286369	191688	0	None	-4	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	2962	64	33	37	-4.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5197030	191688	0	None	-4	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	2962	64	33	37	-4.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	137640703	157073	0	None	-218	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1694	20	20	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4074479	157073	0	None	-218	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1694	20	20	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	25133209	173327	0	None	-56	3	Human	6.6	pKi	=	6.6	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	589	12	3	5	2.4	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)CNC	10.1021/jm800525p
	CHEMBL452710	173327	0	None	-56	3	Human	6.6	pKi	=	6.6	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	589	12	3	5	2.4	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)CNC	10.1021/jm800525p
	25128748	189967	0	None	-28	3	Human	5.6	pKi	=	5.6	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	490	7	2	4	2.3	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](C)C1=O	10.1021/jm800525p
	CHEMBL517108	189967	0	None	-28	3	Human	5.6	pKi	=	5.6	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	490	7	2	4	2.3	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](C)C1=O	10.1021/jm800525p
	CHEMBL50056	214096	2	None	-41	3	Human	5.5	pKi	=	5.5	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm060384p
	11845630	139489	0	None	-5	3	Human	5.5	pKi	=	5.5	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	678	15	5	6	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL379490	139489	0	None	-5	3	Human	5.5	pKi	=	5.5	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	678	15	5	6	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N	10.1021/jm060384p
	11846673	79965	0	None	-3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	515	11	3	4	3.1	CC(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL212766	79965	0	None	-3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	515	11	3	4	3.1	CC(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	44347220	168416	0	None	-112	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	861	11	12	9	-0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCC(C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL434985	168416	0	None	-112	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	861	11	12	9	-0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCC(C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL268851	210746	0	None	-33	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL		None	None	None		CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(N)=O)CCCCNC1=O	10.1021/jm010165y
	44347378	114408	0	None	-6	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	818	11	11	9	0.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NCC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL333262	114408	0	None	-6	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	818	11	11	9	0.1	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NCC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	44434772	88568	0	None	-21	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	6.7	C=C(Br)CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL235582	88568	0	None	-21	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	6.7	C=C(Br)CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	9968756	89480	0	None	-18	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	358	5	1	2	3.7	NCCN(C(=O)Cc1ccc2ccccc2c1)C1CCc2ccccc2C1	10.1016/j.bmc.2007.06.003
	CHEMBL237299	89480	0	None	-18	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	358	5	1	2	3.7	NCCN(C(=O)Cc1ccc2ccccc2c1)C1CCc2ccccc2C1	10.1016/j.bmc.2007.06.003
	44434870	148124	0	None	-13	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	449	8	2	2	5.9	NC1CCCC(N(C/C(Cl)=C/c2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)C1	10.1016/j.bmc.2007.06.003
	CHEMBL393553	148124	0	None	-13	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	449	8	2	2	5.9	NC1CCCC(N(C/C(Cl)=C/c2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)C1	10.1016/j.bmc.2007.06.003
	44413842	138352	0	None	-18	3	Human	4.5	pKi	=	4.5	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	587	14	5	6	1.3	NC(=O)C[C@H](N)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL377210	138352	0	None	-18	3	Human	4.5	pKi	=	4.5	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	587	14	5	6	1.3	NC(=O)C[C@H](N)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL103817	208436	0	None	-52	3	Mouse	6.5	pKi	=	6.5	Binding	Binding constant (Ki) at mouse Melanocortin-3 receptorBinding constant (Ki) at mouse Melanocortin-3 receptor	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	168278271	191091	0	None	-30	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2167	35	34	26	-5.3	CCCC[C@@H]1NC(=O)[C@@H]2CS/C(C(=O)O)=C(/C(N)=O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5187932	191091	0	None	-30	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2167	35	34	26	-5.3	CCCC[C@@H]1NC(=O)[C@@H]2CS/C(C(=O)O)=C(/C(N)=O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	6918276	15579	7	None	-309	8	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
	CHEMBL1221512	15579	7	None	-309	8	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
	CHEMBL415661	213175	0	None	-21	4	Human	8.5	pKi	=	8.5	Binding	Inhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cellsInhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm0501432
	162643435	181643	0	None	-4	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3cccc4ccccc34)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4776340	181643	0	None	-4	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3cccc4ccccc34)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162643435	181643	0	None	-4	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3cccc4ccccc34)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4776340	181643	0	None	-4	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3cccc4ccccc34)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	44416057	81162	0	None	-3	3	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	745	17	6	7	0.2	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H](CCC(N)=O)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL215833	81162	0	None	-3	3	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	745	17	6	7	0.2	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H](CCC(N)=O)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	162643518	181687	0	None	-89	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1075	17	15	12	-1.3	CC(=O)N[C@H](CCCN)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4776915	181687	0	None	-89	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1075	17	15	12	-1.3	CC(=O)N[C@H](CCCN)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162643518	181687	0	None	-89	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1075	17	15	12	-1.3	CC(=O)N[C@H](CCCN)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4776915	181687	0	None	-89	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1075	17	15	12	-1.3	CC(=O)N[C@H](CCCN)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	1323	2669	55	None	-72	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	92432	2669	55	None	-72	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	CHEMBL430239	2669	55	None	-72	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	1323	2669	55	None	-72	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	92432	2669	55	None	-72	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	CHEMBL430239	2669	55	None	-72	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.0c01620
	168271899	190577	0	None	-4	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	3020	70	35	39	-5.6	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5180727	190577	0	None	-4	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	3020	70	35	39	-5.6	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	168271237	190464	0	None	-10	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2788	45	36	36	0.1	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCNC(=O)c3ccc4c(c3)C(=O)OC43c4ccc(O)cc4Oc4cc(O)ccc43)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5179081	190464	0	None	-10	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2788	45	36	36	0.1	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCNC(=O)c3ccc4c(c3)C(=O)OC43c4ccc(O)cc4Oc4cc(O)ccc43)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	44347379	114409	0	None	-5	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	750	9	9	7	0.5	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NC2CCC(C(N)=O)N2C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL333263	114409	0	None	-5	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	750	9	9	7	0.5	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NC2CCC(C(N)=O)N2C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	44347106	115034	0	None	-52	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	738	9	10	7	0.1	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL334309	115034	0	None	-52	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	738	9	10	7	0.1	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	44434872	88535	0	None	-9	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	389	7	2	2	4.8	NC1CCCC(N(Cc2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)C1	10.1016/j.bmc.2007.06.003
	CHEMBL235382	88535	0	None	-9	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	389	7	2	2	4.8	NC1CCCC(N(Cc2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)C1	10.1016/j.bmc.2007.06.003
	44434634	89270	0	None	-16	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	557	11	1	5	6.5	COc1ccc2c(c1)c(CC(=O)N(CCCCN)C/C(C)=C/c1ccccc1)c(C)n2C(=O)c1ccc(Cl)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL236840	89270	0	None	-16	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	557	11	1	5	6.5	COc1ccc2c(c1)c(CC(=O)N(CCCCN)C/C(C)=C/c1ccccc1)c(C)n2C(=O)c1ccc(Cl)cc1	10.1016/j.bmc.2007.06.003
	44434597	89584	0	None	-1	3	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	363	10	2	2	3.9	NCCCN(CCc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237530	89584	0	None	-1	3	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	363	10	2	2	3.9	NCCCN(CCc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL5080784	214683	0	None	-75	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N2	10.1021/acs.jmedchem.1c00095
	25132866	172587	0	None	-77	3	Human	6.5	pKi	=	6.5	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	623	11	2	5	3.9	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)c1ccncc1	10.1021/jm800525p
	CHEMBL449131	172587	0	None	-77	3	Human	6.5	pKi	=	6.5	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	623	11	2	5	3.9	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)c1ccncc1	10.1021/jm800525p
	162672691	183177	0	None	-57	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3cccc4ccccc34)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4795842	183177	0	None	-57	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3cccc4ccccc34)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162672691	183177	0	None	-57	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3cccc4ccccc34)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4795842	183177	0	None	-57	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2cccc(-c3cccc4ccccc34)c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	44562287	174224	0	None	-331	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	548	10	2	5	3.9	CCC(O)(CC)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CN(C)C)CC1	10.1016/j.bmcl.2008.07.076
	CHEMBL454900	174224	0	None	-331	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	548	10	2	5	3.9	CCC(O)(CC)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CN(C)C)CC1	10.1016/j.bmcl.2008.07.076
	25211670	174236	0	None	-323	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	548	10	2	5	4.0	CC(C)CC(O)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CN(C)C)CC1	10.1016/j.bmcl.2008.07.076
	CHEMBL454916	174236	0	None	-323	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	548	10	2	5	4.0	CC(C)CC(O)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CN(C)C)CC1	10.1016/j.bmcl.2008.07.076
	44562460	189241	0	None	-954	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	533	10	3	5	3.8	CC(C)CC(N)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CCN)CC1	10.1016/j.bmcl.2008.07.076
	CHEMBL511826	189241	0	None	-954	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	533	10	3	5	3.8	CC(C)CC(N)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CCN)CC1	10.1016/j.bmcl.2008.07.076
	44434690	89277	0	None	-19	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	545	10	2	2	8.1	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL236861	89277	0	None	-19	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	545	10	2	2	8.1	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434713	89567	0	None	-14	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	541	11	2	3	7.5	COc1ccccc1/C=C/CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL237502	89567	0	None	-14	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	541	11	2	3	7.5	COc1ccccc1/C=C/CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434855	90001	0	None	-10	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	7.5	CC1CC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	CHEMBL238154	90001	0	None	-10	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	7.5	CC1CC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	44434859	90005	0	None	-17	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	529	9	4	3	5.4	NC1CCCC(NC(=O)N[C@H]2CC[C@H](N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)C1	10.1016/j.bmc.2007.06.003
	CHEMBL238158	90005	0	None	-17	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	529	9	4	3	5.4	NC1CCCC(NC(=O)N[C@H]2CC[C@H](N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)C1	10.1016/j.bmc.2007.06.003
	44265487	97354	0	None	-1	4	Human	4.5	pKi	=	4.5	Binding	Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay	ChEMBL	256	6	4	2	1.8	N=C(N)NCCCNCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00088-4
	CHEMBL269689	97354	0	None	-1	4	Human	4.5	pKi	=	4.5	Binding	Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay	ChEMBL	256	6	4	2	1.8	N=C(N)NCCCNCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00088-4
	CHEMBL412494	212974	0	None	-125	3	Human	6.5	pKi	=	6.5	Binding	Inhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cellsInhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H]1CSSC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm0501432
	3198	205490	76	None	-75	34	Human	4.5	pKi	=	4.5	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL1201049	205490	76	None	-75	34	Human	4.5	pKi	=	4.5	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL808	205490	76	None	-75	34	Human	4.5	pKi	=	4.5	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL5077811	214493	0	None	-56	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC(=O)N[C@H]1CSSC[C@@H](C(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/acs.jmedchem.1c00095
	44320339	206100	0	None	-19	4	Human	4.5	pKi	=	4.5	Binding	Binding affinity towards Melanocortin 3 receptor, expressed as negative log of the Ki valueBinding affinity towards Melanocortin 3 receptor, expressed as negative log of the Ki value	ChEMBL	410	9	1	2	6.0	NCCCCCC(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12	10.1021/jm020945m
	CHEMBL85918	206100	0	None	-19	4	Human	4.5	pKi	=	4.5	Binding	Binding affinity towards Melanocortin 3 receptor, expressed as negative log of the Ki valueBinding affinity towards Melanocortin 3 receptor, expressed as negative log of the Ki value	ChEMBL	410	9	1	2	6.0	NCCCCCC(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12	10.1021/jm020945m
	11845440	138647	0	None	-26	3	Human	5.5	pKi	=	5.5	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	613	12	6	6	1.7	N=C(N)NCCNC(=O)[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCNCC1	10.1021/jm060384p
	CHEMBL377778	138647	0	None	-26	3	Human	5.5	pKi	=	5.5	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	613	12	6	6	1.7	N=C(N)NCCNC(=O)[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCNCC1	10.1021/jm060384p
	24741624	138355	0	None	-22	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]NDP-MSH from human MC3R stably expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R stably expressed in HEK293 cells	ChEMBL	525	8	1	4	5.9	COc1cc(Cl)ccc1CC(C)C(=O)N1CCN(c2ccc(C(F)(F)F)cc2[C@@H](N)CC(C)C)CC1	10.1016/j.bmcl.2006.06.075
	CHEMBL377231	138355	0	None	-22	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]NDP-MSH from human MC3R stably expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R stably expressed in HEK293 cells	ChEMBL	525	8	1	4	5.9	COc1cc(Cl)ccc1CC(C)C(=O)N1CCN(c2ccc(C(F)(F)F)cc2[C@@H](N)CC(C)C)CC1	10.1016/j.bmcl.2006.06.075
	24741624	138355	0	None	-22	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]NDPMSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC3R expressed in HEK293 cells	ChEMBL	525	8	1	4	5.9	COc1cc(Cl)ccc1CC(C)C(=O)N1CCN(c2ccc(C(F)(F)F)cc2[C@@H](N)CC(C)C)CC1	10.1021/jm701137s
	CHEMBL377231	138355	0	None	-22	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]NDPMSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC3R expressed in HEK293 cells	ChEMBL	525	8	1	4	5.9	COc1cc(Cl)ccc1CC(C)C(=O)N1CCN(c2ccc(C(F)(F)F)cc2[C@@H](N)CC(C)C)CC1	10.1021/jm701137s
	44397281	126518	0	None	-288	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells	ChEMBL	587	12	3	5	4.0	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(C2(CNCCc3ccccc3)CCCCC2)CC1	10.1016/j.bmcl.2005.05.017
	CHEMBL365237	126518	0	None	-288	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells	ChEMBL	587	12	3	5	4.0	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(C2(CNCCc3ccccc3)CCCCC2)CC1	10.1016/j.bmcl.2005.05.017
	44434633	89141	0	None	-13	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	423	11	2	2	5.3	NCCCCN(C/C(Cl)=C/c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL236630	89141	0	None	-13	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	423	11	2	2	5.3	NCCCCN(C/C(Cl)=C/c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	25129107	173753	0	None	-36	3	Human	6.5	pKi	=	6.5	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	603	11	3	5	2.9	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C(C)(C)N	10.1021/jm800525p
	CHEMBL453734	173753	0	None	-36	3	Human	6.5	pKi	=	6.5	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	603	11	3	5	2.9	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C(C)(C)N	10.1021/jm800525p
	137660993	159423	0	None	-83	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1680	20	21	21	-3.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4101216	159423	0	None	-83	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1680	20	21	21	-3.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	11156852	65655	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptor at 10 uMDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptor at 10 uM	ChEMBL	531	7	3	5	2.9	NCc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2004.06.059
	CHEMBL183434	65655	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptor at 10 uMDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptor at 10 uM	ChEMBL	531	7	3	5	2.9	NCc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2004.06.059
	CHEMBL408257	212681	0	None	-77	3	Human	7.5	pKi	=	7.5	Binding	Inhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cellsInhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H]1CSSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](CCC(=O)O)NC1=O	10.1021/jm0501432
	24740419	148170	0	None	-1318	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]NDPMSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC3R expressed in HEK293 cells	ChEMBL	575	11	1	5	5.4	Cc1ccc([C@@H](CC(C)C)NC(=O)CCN(C)C)c(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3Cl)CC2)n1	10.1021/jm701137s
	CHEMBL393584	148170	0	None	-1318	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]NDPMSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC3R expressed in HEK293 cells	ChEMBL	575	11	1	5	5.4	Cc1ccc([C@@H](CC(C)C)NC(=O)CCN(C)C)c(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3Cl)CC2)n1	10.1021/jm701137s
	44434690	89277	0	None	-19	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	545	10	2	2	8.1	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL236861	89277	0	None	-19	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	545	10	2	2	8.1	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434862	90219	0	None	-20	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	477	10	2	2	6.4	NCC1CCC(CN(C/C(Cl)=C/c2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL238368	90219	0	None	-20	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	477	10	2	2	6.4	NCC1CCC(CN(C/C(Cl)=C/c2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2007.06.003
	10225762	145792	0	None	-4	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	448	14	2	3	5.5	CCN(CC)c1ccc(CN(CCCCCN)C(=O)CCCc2c[nH]c3ccccc23)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL391707	145792	0	None	-4	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	448	14	2	3	5.5	CCN(CC)c1ccc(CN(CCCCCN)C(=O)CCCc2c[nH]c3ccccc23)cc1	10.1016/j.bmc.2007.06.003
	44434601	146443	0	None	-13	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	358	8	1	2	4.3	NCCCN(C/C=C/c1ccccc1)C(=O)Cc1ccc2ccccc2c1	10.1016/j.bmc.2007.06.003
	CHEMBL392223	146443	0	None	-13	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	358	8	1	2	4.3	NCCCN(C/C=C/c1ccccc1)C(=O)Cc1ccc2ccccc2c1	10.1016/j.bmc.2007.06.003
	44265374	206465	0	None	-21	4	Human	4.5	pKi	=	4.5	Binding	Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay	ChEMBL	454	10	2	2	6.4	O=C(O)CCCCCNC(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12	10.1016/s0960-894x(02)00088-4
	CHEMBL8825	206465	0	None	-21	4	Human	4.5	pKi	=	4.5	Binding	Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay	ChEMBL	454	10	2	2	6.4	O=C(O)CCCCCNC(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12	10.1016/s0960-894x(02)00088-4
	44577060	188028	0	None	-97	8	Rat	6.5	pKi	=	6.5	Binding	Binding affinity at rat MC3RBinding affinity at rat MC3R	ChEMBL	530	10	1	4	4.8	CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
	CHEMBL497746	188028	0	None	-97	8	Rat	6.5	pKi	=	6.5	Binding	Binding affinity at rat MC3RBinding affinity at rat MC3R	ChEMBL	530	10	1	4	4.8	CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
	24180592	96984	0	None	-100	6	Mouse	6.5	pKi	=	6.5	Binding	Binding affinity to mouse MC3RBinding affinity to mouse MC3R	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
	CHEMBL266647	96984	0	None	-100	6	Mouse	6.5	pKi	=	6.5	Binding	Binding affinity to mouse MC3RBinding affinity to mouse MC3R	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
	CHEMBL2370966	209946	0	None	-28	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](CCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm030119t
	10232787	140356	0	None	-467	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cell	ChEMBL	619	12	2	5	5.0	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)CC2NCc3ccccc32)CC1	10.1016/j.bmcl.2005.10.103
	CHEMBL380855	140356	0	None	-467	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cell	ChEMBL	619	12	2	5	5.0	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)CC2NCc3ccccc32)CC1	10.1016/j.bmcl.2005.10.103
	44415918	141524	0	None	-17	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	754	16	6	7	0.9	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL384774	141524	0	None	-17	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	754	16	6	7	0.9	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	168295726	192381	0	None	-56	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2547	50	34	33	-2.8	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCOCCOCCC(=O)O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5207936	192381	0	None	-56	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2547	50	34	33	-2.8	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCOCCOCCC(=O)O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	44322923	206523	0	None	-3	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	710	19	10	8	-0.5	N#CCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL88630	206523	0	None	-3	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	710	19	10	8	-0.5	N#CCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	11375764	66659	0	None	-1659	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity for human melanocortin 3 receptorBinding affinity for human melanocortin 3 receptor	ChEMBL	515	6	3	3	5.2	C[C@@H]1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CCN1	10.1021/jm0400496
	CHEMBL185469	66659	0	None	-1659	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity for human melanocortin 3 receptorBinding affinity for human melanocortin 3 receptor	ChEMBL	515	6	3	3	5.2	C[C@@H]1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CCN1	10.1021/jm0400496
	24882666	95689	0	None	1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	385	10	5	3	1.7	N=C(N)NCCC[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccc(F)cc1	10.1016/j.bmcl.2007.11.109
	CHEMBL258295	95689	0	None	1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	385	10	5	3	1.7	N=C(N)NCCC[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccc(F)cc1	10.1016/j.bmcl.2007.11.109
	44393450	123628	0	None	1	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity towards Melanocortin 3 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 3 receptor using [125I]NDP-MSH	ChEMBL	518	6	2	4	3.4	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CC[N+]([O-])(c2ccccc2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	CHEMBL362010	123628	0	None	1	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity towards Melanocortin 3 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 3 receptor using [125I]NDP-MSH	ChEMBL	518	6	2	4	3.4	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CC[N+]([O-])(c2ccccc2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	44416060	81289	0	None	-58	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	734	13	5	6	2.2	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)C2Cc3ccccc3CN2)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL215895	81289	0	None	-58	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	734	13	5	6	2.2	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)C2Cc3ccccc3CN2)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	10325955	165247	0	None	-33	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human Melanocortin 3 receptor (MC3R) using [125I]NDP-alpha-MSH as a radioligand in membranes of HEK 293 cellsBinding affinity towards human Melanocortin 3 receptor (MC3R) using [125I]NDP-alpha-MSH as a radioligand in membranes of HEK 293 cells	ChEMBL	582	8	2	6	3.7	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2Cn2ccnc2)CC1)[C@H]1Cc2ccccc2CN1	10.1021/jm0304109
	CHEMBL423101	165247	0	None	-33	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human Melanocortin 3 receptor (MC3R) using [125I]NDP-alpha-MSH as a radioligand in membranes of HEK 293 cellsBinding affinity towards human Melanocortin 3 receptor (MC3R) using [125I]NDP-alpha-MSH as a radioligand in membranes of HEK 293 cells	ChEMBL	582	8	2	6	3.7	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccccc2Cn2ccnc2)CC1)[C@H]1Cc2ccccc2CN1	10.1021/jm0304109
	11786860	66304	1	None	-281	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptor	ChEMBL	614	9	4	6	3.4	CC(N[C@H]1CCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2004.06.059
	CHEMBL185035	66304	1	None	-281	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptorDisplacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-3 receptor	ChEMBL	614	9	4	6	3.4	CC(N[C@H]1CCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2004.06.059
	44434685	89142	0	None	-17	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	497	14	3	3	6.3	NCCCCCCN(Cc1ccccc1)C(=O)CCCc1c(Cc2ccc(O)cc2)[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL236638	89142	0	None	-17	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	497	14	3	3	6.3	NCCCCCCN(Cc1ccccc1)C(=O)CCCc1c(Cc2ccc(O)cc2)[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434652	89872	0	None	-16	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	403	12	2	2	5.2	NCCCCCN(C/C=C\c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237912	89872	0	None	-16	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	403	12	2	2	5.2	NCCCCCN(C/C=C\c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	168289584	191762	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	3108	98	37	41	-6.4	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CSC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CSC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5198158	191762	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	3108	98	37	41	-6.4	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CSC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CSC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	168294114	192166	0	None	-16	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	4756	82	66	59	-5.7	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCOCCNC(=O)OCC3C4CCc5c6nnc(c5CCC43)SC[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](CS6)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC3=O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5204285	192166	0	None	-16	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	4756	82	66	59	-5.7	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCOCCNC(=O)OCC3C4CCc5c6nnc(c5CCC43)SC[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](CS6)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC3=O)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	44323211	106991	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsBinding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	768	7	9	8	-0.1	C[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL315397	106991	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsBinding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	768	7	9	8	-0.1	C[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	44434666	88530	0	None	1	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	434	9	1	3	5.8	NCCCCCN(C(=O)COc1ccc2ccccc2c1)C1CCC2(CC=CCC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL235356	88530	0	None	1	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	434	9	1	3	5.8	NCCCCCN(C(=O)COc1ccc2ccccc2c1)C1CCC2(CC=CCC2)CC1	10.1016/j.bmc.2007.06.003
	44265672	10149	0	None	-16	4	Human	4.4	pKi	=	4.4	Binding	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptor	ChEMBL	442	10	5	3	3.1	NC(N)=NCCC[C@H](NCc1ccc2ccccc2c1)C(=O)NCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00089-6
	CHEMBL1159699	10149	0	None	-16	4	Human	4.4	pKi	=	4.4	Binding	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptor	ChEMBL	442	10	5	3	3.1	NC(N)=NCCC[C@H](NCc1ccc2ccccc2c1)C(=O)NCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00089-6
	44434754	90207	0	None	-14	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	557	11	3	4	7.2	COc1cc(O)ccc1/C=C/CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL238345	90207	0	None	-14	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	557	11	3	4	7.2	COc1cc(O)ccc1/C=C/CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	10292084	148371	0	None	-15	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	361	6	2	2	3.4	NCCCN(C(=O)Cc1c[nH]c2ccccc12)C1CCc2ccccc2C1	10.1016/j.bmc.2007.06.003
	CHEMBL393755	148371	0	None	-15	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	361	6	2	2	3.4	NCCCN(C(=O)Cc1c[nH]c2ccccc12)C1CCc2ccccc2C1	10.1016/j.bmc.2007.06.003
	25133208	171970	0	None	-34	3	Human	6.4	pKi	=	6.4	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	615	11	3	5	3.1	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1(N)CCC1	10.1021/jm800525p
	CHEMBL447117	171970	0	None	-34	3	Human	6.4	pKi	=	6.4	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	615	11	3	5	3.1	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1(N)CCC1	10.1021/jm800525p
	168281969	191254	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	3072	100	37	39	-7.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5190661	191254	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	3072	100	37	39	-7.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	44322994	106970	0	None	-4	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	715	20	9	8	-1.0	COCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL315258	106970	0	None	-4	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	715	20	9	8	-1.0	COCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	44577063	188076	0	None	-70	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	544	8	1	4	4.9	CC(C)[C@H](NC(=O)C1CN(C)C1)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
	CHEMBL498150	188076	0	None	-70	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	544	8	1	4	4.9	CC(C)[C@H](NC(=O)C1CN(C)C1)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
	CHEMBL5090670	215254	0	None	-37	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	44434616	88666	0	None	-2	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	377	10	2	2	4.8	CCC(c1ccccc1)N(CCCCN)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL236003	88666	0	None	-2	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	377	10	2	2	4.8	CCC(c1ccccc1)N(CCCCN)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	10159196	89709	0	None	-6	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	421	11	2	4	4.4	NCCCCCN(Cc1ccc2c(c1)OCO2)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237694	89709	0	None	-6	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	421	11	2	4	4.4	NCCCCCN(Cc1ccc2c(c1)OCO2)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434635	168863	0	None	-3	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	363	10	2	2	4.3	NCCCCN(Cc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL438334	168863	0	None	-3	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	363	10	2	2	4.3	NCCCCN(Cc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44409206	140159	0	None	-5	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	567	13	4	4	4.8	N=C(N)NCCC[C@H]1C[C@@H](OCc2ccccc2)CN1C(=O)[C@H](CC[C@H]1Cc2ccccc2CN1)Cc1ccccc1	10.1016/j.bmcl.2005.12.005
	CHEMBL380437	140159	0	None	-5	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	567	13	4	4	4.8	N=C(N)NCCC[C@H]1C[C@@H](OCc2ccccc2)CN1C(=O)[C@H](CC[C@H]1Cc2ccccc2CN1)Cc1ccccc1	10.1016/j.bmcl.2005.12.005
	11847312	79733	0	None	-6	3	Human	5.4	pKi	=	5.4	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	613	12	6	6	1.8	N=C(N)NCCNC(=O)[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCCN1	10.1021/jm060384p
	CHEMBL211798	79733	0	None	-6	3	Human	5.4	pKi	=	5.4	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	613	12	6	6	1.8	N=C(N)NCCNC(=O)[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCCN1	10.1021/jm060384p
	CHEMBL5077095	214456	0	None	-346	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL5090285	215230	0	None	-138	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	137646617	157520	0	None	-8	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1728	21	21	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4080223	157520	0	None	-8	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1728	21	21	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	46877881	201795	0	None	-2	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsBinding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	813	9	10	8	-0.3	N=C(N)NCCC[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL606990	201795	0	None	-2	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsBinding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	813	9	10	8	-0.3	N=C(N)NCCC[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C(=O)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	44400813	71057	0	None	-134	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	603	12	4	6	3.9	O=C(NCCO)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	CHEMBL195308	71057	0	None	-134	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	603	12	4	6	3.9	O=C(NCCO)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	9958649	124331	0	None	-354	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity for human melanocortin 3 receptorBinding affinity for human melanocortin 3 receptor	ChEMBL	529	6	3	3	5.6	CC1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CC(C)N1	10.1021/jm0400496
	CHEMBL363730	124331	0	None	-354	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity for human melanocortin 3 receptorBinding affinity for human melanocortin 3 receptor	ChEMBL	529	6	3	3	5.6	CC1CN(/C(=N/c2ccc(C(=O)NCCc3ccc(Cl)cc3Cl)cc2)NC2CCCCC2)CC(C)N1	10.1021/jm0400496
	156015336	177495	0	None	-1	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in CHO-K1 cell membranes incubated for 3 hrs by top-count beta countingDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in CHO-K1 cell membranes incubated for 3 hrs by top-count beta counting	ChEMBL	3793	77	53	60	-15.9	CC[C@H](C)[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CSSC[C@@H](C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CCC(N)=O)CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N3)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2	10.1021/acs.jmedchem.0c00485
	CHEMBL4639782	177495	0	None	-1	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in CHO-K1 cell membranes incubated for 3 hrs by top-count beta countingDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in CHO-K1 cell membranes incubated for 3 hrs by top-count beta counting	ChEMBL	3793	77	53	60	-15.9	CC[C@H](C)[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CSSC[C@@H](C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CCC(N)=O)CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N3)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2	10.1021/acs.jmedchem.0c00485
	44434658	90206	0	None	-3	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	389	10	2	3	3.9	NCCCCCN(Cc1ccccc1)C(=O)[C@@H](N)Cc1ccc2ccccc2c1	10.1016/j.bmc.2007.06.003
	CHEMBL238342	90206	0	None	-3	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	389	10	2	3	3.9	NCCCCCN(Cc1ccccc1)C(=O)[C@@H](N)Cc1ccc2ccccc2c1	10.1016/j.bmc.2007.06.003
	44434714	148368	0	None	-8	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	486	9	2	3	6.4	NC1CCC(CC2CCC(N(Cc3ccccn3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL393753	148368	0	None	-8	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	486	9	2	3	6.4	NC1CCC(CC2CCC(N(Cc3ccccn3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	137660671	159194	0	None	-416	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1708	20	19	21	-2.8	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4098785	159194	0	None	-416	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1708	20	19	21	-2.8	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N(C)[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	168290510	191873	0	None	-20	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	1215	15	14	15	-1.3	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5199932	191873	0	None	-20	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	1215	15	14	15	-1.3	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5085972	214980	0	None	-20	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.1c00095
	CHEMBL385556	212331	0	None	-173	3	Human	6.4	pKi	=	6.4	Binding	Inhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cellsInhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H]1CSSC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm0501432
	CHEMBL3577981	211726	1	None	-31	3	Mouse	6.4	pKi	=	6.4	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	10077773	87238	4	None	-204	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]NDP-alphaMSH from human melanocortin 3 receptor expressed in CHOK1 cellsDisplacement of [125I]NDP-alphaMSH from human melanocortin 3 receptor expressed in CHOK1 cells	ChEMBL	559	14	1	6	7.4	CC(=O)c1ccc(Nc2nc3ccc(C(=O)N(CCC(C)C)CCC(C)C)cc3n2CCCN2CCCCC2)cc1	10.1016/j.bmcl.2007.06.010
	CHEMBL233135	87238	4	None	-204	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]NDP-alphaMSH from human melanocortin 3 receptor expressed in CHOK1 cellsDisplacement of [125I]NDP-alphaMSH from human melanocortin 3 receptor expressed in CHOK1 cells	ChEMBL	559	14	1	6	7.4	CC(=O)c1ccc(Nc2nc3ccc(C(=O)N(CCC(C)C)CCC(C)C)cc3n2CCCN2CCCCC2)cc1	10.1016/j.bmcl.2007.06.010
	44434850	89145	0	None	-10	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	461	9	2	2	6.3	NCc1ccc(CN(Cc2ccc3ccccc3c2)C(=O)CCCc2c[nH]c3ccccc23)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL236645	89145	0	None	-10	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	461	9	2	2	6.3	NCc1ccc(CN(Cc2ccc3ccccc3c2)C(=O)CCCc2c[nH]c3ccccc23)cc1	10.1016/j.bmc.2007.06.003
	11845276	80024	0	None	-2	3	Human	6.4	pKi	=	6.4	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	605	14	4	4	4.9	N=C(N)NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)CCc1ccccc1	10.1021/jm060384p
	CHEMBL212976	80024	0	None	-2	3	Human	6.4	pKi	=	6.4	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	605	14	4	4	4.9	N=C(N)NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)CCc1ccccc1	10.1021/jm060384p
	CHEMBL5076315	214405	0	None	-51	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](C)C(=O)N2	10.1021/acs.jmedchem.1c00095
	168281969	191254	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	3072	100	37	39	-7.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5190661	191254	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	3072	100	37	39	-7.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	44434657	90205	0	None	-8	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	389	10	2	3	3.9	NCCCCCN(Cc1ccccc1)C(=O)[C@H](N)Cc1ccc2ccccc2c1	10.1016/j.bmc.2007.06.003
	CHEMBL238341	90205	0	None	-8	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	389	10	2	3	3.9	NCCCCCN(Cc1ccccc1)C(=O)[C@H](N)Cc1ccc2ccccc2c1	10.1016/j.bmc.2007.06.003
	44415991	80481	0	None	-21	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	519	9	3	5	1.6	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCN)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL214770	80481	0	None	-21	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	519	9	3	5	1.6	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCN)C1=O	10.1016/j.bmcl.2006.05.087
	44415991	80481	0	None	-21	3	Human	5.4	pKi	=	5.4	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	519	9	3	5	1.6	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCN)C1=O	10.1021/jm800525p
	CHEMBL214770	80481	0	None	-21	3	Human	5.4	pKi	=	5.4	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	519	9	3	5	1.6	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCN)C1=O	10.1021/jm800525p
	44413831	78035	0	None	-6	3	Human	5.4	pKi	=	5.4	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	632	12	5	5	4.0	N=C(N)NCCC[C@@H]1C[C@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1Cc2ccccc2CN1	10.1021/jm060384p
	CHEMBL210008	78035	0	None	-6	3	Human	5.4	pKi	=	5.4	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	632	12	5	5	4.0	N=C(N)NCCC[C@@H]1C[C@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1Cc2ccccc2CN1	10.1021/jm060384p
	57817773	76896	0	None	-245	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1918	56	24	26	-3.6	CCCC[C@H](NC(=O)[C@H](CN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	70684623	76896	0	None	-245	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1918	56	24	26	-3.6	CCCC[C@H](NC(=O)[C@H](CN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	91929806	76896	0	None	-245	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1918	56	24	26	-3.6	CCCC[C@H](NC(=O)[C@H](CN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	CHEMBL2070249	76896	0	None	-245	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1918	56	24	26	-3.6	CCCC[C@H](NC(=O)[C@H](CN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	44413930	138623	0	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	678	15	5	6	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL377620	138623	0	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	678	15	5	6	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL433645	213620	0	None	-104	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL		None	None	None		NC(=O)[C@H]1CCCCNC(=O)C[C@H](N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1	10.1021/jm010165y
	23635235	166477	0	None	-177	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]NDP-MSH from human MC3RDisplacement of [125I]NDP-MSH from human MC3R	ChEMBL	526	10	1	4	4.9	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1021/jm070806a
	CHEMBL427860	166477	0	None	-177	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]NDP-MSH from human MC3RDisplacement of [125I]NDP-MSH from human MC3R	ChEMBL	526	10	1	4	4.9	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1021/jm070806a
	44410803	140147	0	None	-398	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cell	ChEMBL	633	12	2	5	5.0	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)CC2NCCc3ccccc32)CC1	10.1016/j.bmcl.2005.10.103
	CHEMBL380365	140147	0	None	-398	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cell	ChEMBL	633	12	2	5	5.0	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)CC2NCCc3ccccc32)CC1	10.1016/j.bmcl.2005.10.103
	44434687	159468	0	None	-8	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	465	14	2	2	6.5	NCCCCCCCN(C/C(Cl)=C/c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL410179	159468	0	None	-8	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	465	14	2	2	6.5	NCCCCCCCN(C/C(Cl)=C/c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	11846844	140054	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	678	15	5	6	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL380051	140054	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	678	15	5	6	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	137653925	158583	0	None	-18	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1742	21	20	21	-2.9	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4092141	158583	0	None	-18	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1742	21	20	21	-2.9	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	25128751	173560	0	None	-11	3	Human	6.4	pKi	=	6.4	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	629	11	2	6	4.0	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)c1cscn1	10.1021/jm800525p
	CHEMBL453300	173560	0	None	-11	3	Human	6.4	pKi	=	6.4	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	629	11	2	6	4.0	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)c1cscn1	10.1021/jm800525p
	CHEMBL438030	213721	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O	10.1021/jm030119t
	44434855	90001	0	None	-10	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	7.5	CC1CC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	CHEMBL238154	90001	0	None	-10	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	7.5	CC1CC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	44434684	146574	0	None	-12	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	391	12	2	2	5.0	NCCCCCCN(Cc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL392315	146574	0	None	-12	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	391	12	2	2	5.0	NCCCCCCN(Cc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434665	147924	0	None	-1	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	378	10	3	3	3.2	NCCCCCN(Cc1ccccc1)C(=O)[C@@H](N)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL393383	147924	0	None	-1	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	378	10	3	3	3.2	NCCCCCN(Cc1ccccc1)C(=O)[C@@H](N)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	25133207	172919	0	None	-16	3	Human	6.4	pKi	=	6.4	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	601	11	3	5	2.7	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1(N)CC1	10.1021/jm800525p
	CHEMBL451694	172919	0	None	-16	3	Human	6.4	pKi	=	6.4	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	601	11	3	5	2.7	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1(N)CC1	10.1021/jm800525p
	11845438	137598	0	None	-10	3	Human	5.4	pKi	=	5.4	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	661	12	6	6	2.4	N=C(N)NCCNC(=O)[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1	10.1021/jm060384p
	CHEMBL375775	137598	0	None	-10	3	Human	5.4	pKi	=	5.4	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	661	12	6	6	2.4	N=C(N)NCCNC(=O)[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1	10.1021/jm060384p
	44323034	206507	0	None	-12	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	729	21	11	8	-0.6	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCCO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL88537	206507	0	None	-12	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	729	21	11	8	-0.6	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCCO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL91957	215882	0	None	-6	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NS(=O)(=O)c1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	10257541	126316	0	None	-269	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards Melanocortin 3 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 3 receptor using [125I]NDP-MSH	ChEMBL	575	7	2	7	3.0	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN([C@@H]2CCCC[C@H]2n2cncn2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	CHEMBL365039	126316	0	None	-269	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards Melanocortin 3 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 3 receptor using [125I]NDP-MSH	ChEMBL	575	7	2	7	3.0	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN([C@@H]2CCCC[C@H]2n2cncn2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	44434851	89880	0	None	-16	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	437	10	2	2	5.7	NCc1ccc(CN(C/C=C/c2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL237930	89880	0	None	-16	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	437	10	2	2	5.7	NCc1ccc(CN(C/C=C/c2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)cc1	10.1016/j.bmc.2007.06.003
	10155513	151517	0	None	-4	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	361	8	2	2	4.0	C/C(=C\c1ccccc1)CN(CCCN)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL396303	151517	0	None	-4	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	361	8	2	2	4.0	C/C(=C\c1ccccc1)CN(CCCN)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL2070242	209160	0	None	-9	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(C)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	44400810	124034	0	None	-316	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	601	11	3	5	5.4	CC(C)NC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	CHEMBL363190	124034	0	None	-316	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	601	11	3	5	5.4	CC(C)NC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	CHEMBL2070373	209163	0	None	-57	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	44434562	88669	0	None	-562	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]NDP-MSH from MC3R receptor in HEK293 cellsDisplacement of [125I]NDP-MSH from MC3R receptor in HEK293 cells	ChEMBL	551	10	3	5	3.9	CC(C)C[C@H](N)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CCN)CC1	10.1016/j.bmc.2007.05.026
	CHEMBL236014	88669	0	None	-562	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]NDP-MSH from MC3R receptor in HEK293 cellsDisplacement of [125I]NDP-MSH from MC3R receptor in HEK293 cells	ChEMBL	551	10	3	5	3.9	CC(C)C[C@H](N)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CCN)CC1	10.1016/j.bmc.2007.05.026
	44577094	178623	0	None	-134	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	546	10	1	4	5.3	CC(C)[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
	CHEMBL467588	178623	0	None	-134	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	546	10	1	4	5.3	CC(C)[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
	1338	3778	43	None	-75	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards Melanocortin 3 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 3 receptor using [125I]NDP-MSH	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm0311285
	9938402	3778	43	None	-75	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards Melanocortin 3 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 3 receptor using [125I]NDP-MSH	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm0311285
	CHEMBL339053	3778	43	None	-75	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards Melanocortin 3 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 3 receptor using [125I]NDP-MSH	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1021/jm0311285
	44432964	87424	0	None	-1148	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]NDP-alphaMSH from human melanocortin 3 receptor expressed in CHOK1 cellsDisplacement of [125I]NDP-alphaMSH from human melanocortin 3 receptor expressed in CHOK1 cells	ChEMBL	558	14	0	5	7.2	CC(=O)c1ccc(Cc2nc3ccc(C(=O)N(CCC(C)C)CCC(C)C)cc3n2CCCN2CCCCC2)cc1	10.1016/j.bmcl.2007.06.010
	CHEMBL233372	87424	0	None	-1148	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]NDP-alphaMSH from human melanocortin 3 receptor expressed in CHOK1 cellsDisplacement of [125I]NDP-alphaMSH from human melanocortin 3 receptor expressed in CHOK1 cells	ChEMBL	558	14	0	5	7.2	CC(=O)c1ccc(Cc2nc3ccc(C(=O)N(CCC(C)C)CCC(C)C)cc3n2CCCN2CCCCC2)cc1	10.1016/j.bmcl.2007.06.010
	44453903	155400	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	387	9	2	5	2.7	N[C@H](Cc1ccc(F)cc1)C(=O)NCCC(Cn1cncn1)C1CCCCC1	10.1016/j.bmcl.2007.11.109
	CHEMBL403722	155400	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	387	9	2	5	2.7	N[C@H](Cc1ccc(F)cc1)C(=O)NCCC(Cn1cncn1)C1CCCCC1	10.1016/j.bmcl.2007.11.109
	44434865	88721	0	None	-14	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	589	10	4	3	6.5	NC1CCCC(NC(=O)NC2CCCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C2)C1	10.1016/j.bmc.2007.06.003
	CHEMBL236226	88721	0	None	-14	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	589	10	4	3	6.5	NC1CCCC(NC(=O)NC2CCCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C2)C1	10.1016/j.bmc.2007.06.003
	44434690	89876	0	None	-14	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	545	10	2	2	8.1	N[C@H]1CC[C@H](C[C@H]2CC[C@H](N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL237920	89876	0	None	-14	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	545	10	2	2	8.1	N[C@H]1CC[C@H](C[C@H]2CC[C@H](N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434849	146831	0	None	-23	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	411	9	2	2	5.2	NCc1cccc(CN(Cc2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)c1	10.1016/j.bmc.2007.06.003
	CHEMBL392521	146831	0	None	-23	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	411	9	2	2	5.2	NCc1cccc(CN(Cc2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)c1	10.1016/j.bmc.2007.06.003
	44434614	151560	1	None	-2	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	349	9	2	2	3.9	NCCCN(Cc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL396341	151560	1	None	-2	4	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	349	9	2	2	3.9	NCCCN(Cc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44265472	206332	0	None	-3	3	Human	4.4	pKi	=	4.4	Binding	Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay	ChEMBL	245	6	5	2	1.1	N=C(N)NCCCNCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00088-4
	CHEMBL8742	206332	0	None	-3	3	Human	4.4	pKi	=	4.4	Binding	Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay	ChEMBL	245	6	5	2	1.1	N=C(N)NCCCNCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00088-4
	51346771	58196	0	None	-13	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in BHK cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in BHK cells	ChEMBL	671	10	2	9	3.3	COCC(=O)N[C@H]1Cc2cc3c(c(c2)Cc2ccc(cc2)Oc2cccc(c2)CN(CCCN2CCN(CCCN)CC2)C1=O)OCOC3	10.1016/j.bmcl.2011.01.011
	CHEMBL1682208	58196	0	None	-13	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in BHK cellsDisplacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in BHK cells	ChEMBL	671	10	2	9	3.3	COCC(=O)N[C@H]1Cc2cc3c(c(c2)Cc2ccc(cc2)Oc2cccc(c2)CN(CCCN2CCN(CCCN)CC2)C1=O)OCOC3	10.1016/j.bmcl.2011.01.011
	16132144	209256	36	None	-30	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm201489a
	16133793	209256	36	None	-30	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm201489a
	44273719	209256	36	None	-30	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm201489a
	CHEMBL214332	209256	36	None	-30	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	10.1021/jm201489a
	44410802	140360	0	None	-263	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cell	ChEMBL	633	12	1	5	5.3	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)CC2c3ccccc3CN2C)CC1	10.1016/j.bmcl.2005.10.103
	CHEMBL380858	140360	0	None	-263	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cell	ChEMBL	633	12	1	5	5.3	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)CC2c3ccccc3CN2C)CC1	10.1016/j.bmcl.2005.10.103
	44434686	146575	0	None	-15	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	407	11	3	3	4.7	CC(Cc1ccccc1)CN(CCCCCCN)C(=O)c1cc2cc(O)ccc2[nH]1	10.1016/j.bmc.2007.06.003
	CHEMBL392316	146575	0	None	-15	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	407	11	3	3	4.7	CC(Cc1ccccc1)CN(CCCCCCN)C(=O)c1cc2cc(O)ccc2[nH]1	10.1016/j.bmc.2007.06.003
	44434698	171001	0	None	-16	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	649	12	3	5	8.1	COC(=O)c1ccc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	CHEMBL445669	171001	0	None	-16	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	649	12	3	5	8.1	COC(=O)c1ccc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1	10.1016/j.bmc.2007.06.003
	44416122	80099	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	576	11	4	5	1.7	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCCNC(N)=O)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL213284	80099	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	576	11	4	5	1.7	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCCNC(N)=O)C1=O	10.1016/j.bmcl.2006.05.087
	44409104	76496	0	None	-36	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	582	12	5	5	2.9	N=C(N)NCCC[C@H]1C[C@@H](OCc2ccccc2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.12.005
	CHEMBL206033	76496	0	None	-36	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	582	12	5	5	2.9	N=C(N)NCCC[C@H]1C[C@@H](OCc2ccccc2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1Cc2ccccc2CN1	10.1016/j.bmcl.2005.12.005
	44347221	16603	0	None	-53	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	903	11	12	9	0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL124169	16603	0	None	-53	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	903	11	12	9	0.3	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	44416135	80155	0	None	-42	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	561	10	5	5	1.1	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCNC(=N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL213566	80155	0	None	-42	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	561	10	5	5	1.1	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCNC(=N)N)C1=O	10.1016/j.bmcl.2006.05.087
	44416135	80155	0	None	-42	3	Human	6.3	pKi	=	6.3	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	561	10	5	5	1.1	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCNC(=N)N)C1=O	10.1021/jm800525p
	CHEMBL213566	80155	0	None	-42	3	Human	6.3	pKi	=	6.3	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	561	10	5	5	1.1	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCNC(=N)N)C1=O	10.1021/jm800525p
	44434663	88486	0	None	-23	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	483	13	3	3	5.9	NCCCCCN(Cc1ccccc1)C(=O)CCCc1c(Cc2ccc(O)cc2)[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL235138	88486	0	None	-23	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	483	13	3	3	5.9	NCCCCCN(Cc1ccccc1)C(=O)CCCc1c(Cc2ccc(O)cc2)[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434637	89383	0	None	-5	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	377	11	2	2	4.3	NCCCCCN(CCCc1ccccc1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237052	89383	0	None	-5	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	377	11	2	2	4.3	NCCCCCN(CCCc1ccccc1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	25129108	172672	0	None	-33	3	Human	6.3	pKi	=	6.3	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	629	11	3	5	3.5	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1(N)CCCC1	10.1021/jm800525p
	CHEMBL450236	172672	0	None	-33	3	Human	6.3	pKi	=	6.3	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	629	11	3	5	3.5	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1(N)CCCC1	10.1021/jm800525p
	CHEMBL5091236	215276	0	None	-602	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL441760	213873	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC1=O	10.1021/jm030119t
	44265751	106071	0	None	-1	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptor	ChEMBL	412	12	7	4	0.3	N=C(N)NCCCNC(=O)[C@H](CCCN=C(N)N)NCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00089-6
	CHEMBL313379	106071	0	None	-1	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptor	ChEMBL	412	12	7	4	0.3	N=C(N)NCCCNC(=O)[C@H](CCCN=C(N)N)NCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00089-6
	44434611	88585	0	None	-7	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	373	6	2	2	3.9	NCCCN(C(=O)/C=C/c1c[nH]c2ccccc12)C1CCc2ccccc2C1	10.1016/j.bmc.2007.06.003
	CHEMBL235627	88585	0	None	-7	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	373	6	2	2	3.9	NCCCN(C(=O)/C=C/c1c[nH]c2ccccc12)C1CCc2ccccc2C1	10.1016/j.bmc.2007.06.003
	44401392	68628	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	582	14	5	4	3.1	N=C(N)NCCC[C@H](NC(=O)CCc1ccccc1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	CHEMBL191975	68628	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	582	14	5	4	3.1	N=C(N)NCCC[C@H](NC(=O)CCc1ccccc1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	44577060	188028	0	None	-141	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	530	10	1	4	4.8	CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
	CHEMBL497746	188028	0	None	-141	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	530	10	1	4	4.8	CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
	44434580	151879	0	None	-2	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	335	8	2	2	3.5	NCCN(Cc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL396598	151879	0	None	-2	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	335	8	2	2	3.5	NCCN(Cc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	168281421	190933	0	None	-89	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2430	43	34	31	-3.4	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCN)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5185945	190933	0	None	-89	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2430	43	34	31	-3.4	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCN)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	168284256	190922	0	None	-14	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2383	48	33	31	-4.2	CCCC[C@@H]1NC(=O)[C@@H]2CSC/C(=N/OCC(=O)NCCOCCOCCOCCN=[N+]=[N-])CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5185775	190922	0	None	-14	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	2383	48	33	31	-4.2	CCCC[C@@H]1NC(=O)[C@@H]2CSC/C(=N/OCC(=O)NCCOCCOCCOCCN=[N+]=[N-])CSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL409636	212750	0	None	1	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@H]1CC(=O)NCCCC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O	10.1021/jm030119t
	44322868	105981	0	None	4	3	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsBinding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	917	11	12	9	0.7	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL313279	105981	0	None	4	3	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsBinding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	917	11	12	9	0.7	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL253364	210486	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL		None	None	None		N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](N)CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm070461w
	44413931	77986	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	643	16	5	6	1.9	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL209789	77986	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	643	16	5	6	1.9	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL5087839	215097	0	None	-69	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc3ccccc3c1)C(=O)N[C@@H](C)C(=O)N2	10.1021/acs.jmedchem.1c00095
	71458055	78999	0	None	7	4	Human	6.3	pKi	=	6.3	Binding	Inhibition of [125I]-NDP MSH binding towards human melanocortin 3 receptorInhibition of [125I]-NDP MSH binding towards human melanocortin 3 receptor	ChEMBL	599	6	2	5	3.7	CC(=O)N1CCCc2cccc(N3CCN(C(=O)[C@@H](Cc4ccc(Cl)cc4)NC(=O)[C@H]4Cc5ccccc5CN4)CC3)c21	10.1016/j.bmcl.2005.07.035
	CHEMBL2113133	78999	0	None	7	4	Human	6.3	pKi	=	6.3	Binding	Inhibition of [125I]-NDP MSH binding towards human melanocortin 3 receptorInhibition of [125I]-NDP MSH binding towards human melanocortin 3 receptor	ChEMBL	599	6	2	5	3.7	CC(=O)N1CCCc2cccc(N3CCN(C(=O)[C@@H](Cc4ccc(Cl)cc4)NC(=O)[C@H]4Cc5ccccc5CN4)CC3)c21	10.1016/j.bmcl.2005.07.035
	16038315	138733	0	None	-741	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	612	13	3	7	3.5	COc1ccccc1CCNCc1cccnc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CCN)CC1	10.1016/j.bmcl.2006.04.069
	CHEMBL378046	138733	0	None	-741	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	612	13	3	7	3.5	COc1ccccc1CCNCc1cccnc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CCN)CC1	10.1016/j.bmcl.2006.04.069
	44434839	88624	0	None	-4	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	441	10	4	2	4.5	N=C(N)NCCCCN(Cc1ccc2ccccc2c1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL235802	88624	0	None	-4	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	441	10	4	2	4.5	N=C(N)NCCCCN(Cc1ccc2ccccc2c1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	10157774	89272	0	None	-33	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	399	9	2	2	5.0	NCCCCCN(Cc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL236842	89272	0	None	-33	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	399	9	2	2	5.0	NCCCCCN(Cc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434861	90218	0	None	-11	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	389	7	2	2	4.8	N[C@H]1CC[C@H](N(Cc2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL238367	90218	0	None	-11	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	389	7	2	2	4.8	N[C@H]1CC[C@H](N(Cc2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2007.06.003
	44413881	137568	0	None	1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	707	15	6	7	1.9	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1C(=O)NCCN=C(N)N	10.1021/jm060384p
	CHEMBL375559	137568	0	None	1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	707	15	6	7	1.9	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1C(=O)NCCN=C(N)N	10.1021/jm060384p
	44265751	106071	0	None	-1	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards Melanocortin 3 receptor, expressed as negative log of the Ki valueBinding affinity towards Melanocortin 3 receptor, expressed as negative log of the Ki value	ChEMBL	412	12	7	4	0.3	N=C(N)NCCCNC(=O)[C@H](CCCN=C(N)N)NCc1ccc2ccccc2c1	10.1021/jm020945m
	CHEMBL313379	106071	0	None	-1	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards Melanocortin 3 receptor, expressed as negative log of the Ki valueBinding affinity towards Melanocortin 3 receptor, expressed as negative log of the Ki value	ChEMBL	412	12	7	4	0.3	N=C(N)NCCCNC(=O)[C@H](CCCN=C(N)N)NCc1ccc2ccccc2c1	10.1021/jm020945m
	CHEMBL5091245	215277	0	None	-120	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	10025669	97363	0	None	-79	4	Human	4.3	pKi	=	4.3	Binding	Binding affinity towards Melanocortin 3 receptor, expressed as negative log of the Ki valueBinding affinity towards Melanocortin 3 receptor, expressed as negative log of the Ki value	ChEMBL	429	11	5	4	3.0	NCCCNC(=O)[C@H](CNCc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1	10.1021/jm020945m
	CHEMBL269776	97363	0	None	-79	4	Human	4.3	pKi	=	4.3	Binding	Binding affinity towards Melanocortin 3 receptor, expressed as negative log of the Ki valueBinding affinity towards Melanocortin 3 receptor, expressed as negative log of the Ki value	ChEMBL	429	11	5	4	3.0	NCCCNC(=O)[C@H](CNCc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1	10.1021/jm020945m
	168276294	190484	0	None	-23	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	3264	55	36	40	1.5	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCOCCNC(=O)OCC3C4CCc5nnn(CC(=O)N6CCCC[C@H]6C6(O)CN(C(=O)c7ccc(F)c(F)c7Nc7ccc(I)cc7F)C6)c5CCC43)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5179373	190484	0	None	-23	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	3264	55	36	40	1.5	CCCC[C@@H]1NC(=O)[C@@H]2CSc3nnc(c4c3CCC3C(CC4)C3COC(=O)NCCOCCOCCOCCNC(=O)OCC3C4CCc5nnn(CC(=O)N6CCCC[C@H]6C6(O)CN(C(=O)c7ccc(F)c(F)c7Nc7ccc(I)cc7F)C6)c5CCC43)SC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.2c00793
	CHEMBL5087859	215100	0	None	-741	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	44434570	89750	0	None	-3	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	347	8	2	2	3.6	NCCN(C/C=C/c1ccccc1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237719	89750	0	None	-3	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	347	8	2	2	3.6	NCCN(C/C=C/c1ccccc1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434754	90207	0	None	-14	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	557	11	3	4	7.2	COc1cc(O)ccc1/C=C/CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL238345	90207	0	None	-14	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	557	11	3	4	7.2	COc1cc(O)ccc1/C=C/CN(C(=O)CCCc1c[nH]c2ccccc12)C1CCC(CC2CCC(N)CC2)CC1	10.1016/j.bmc.2007.06.003
	44393417	96562	0	None	-13	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards Melanocortin 3 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 3 receptor using [125I]NDP-MSH	ChEMBL	589	8	2	7	3.1	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(C2CCCCC2Cn2cncn2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	CHEMBL263182	96562	0	None	-13	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards Melanocortin 3 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 3 receptor using [125I]NDP-MSH	ChEMBL	589	8	2	7	3.1	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(C2CCCCC2Cn2cncn2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	44434770	88532	0	None	-29	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	521	9	2	2	7.3	NC1CCC(CC2CCC(N(Cc3c(F)cccc3F)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL235359	88532	0	None	-29	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	521	9	2	2	7.3	NC1CCC(CC2CCC(N(Cc3c(F)cccc3F)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434857	154403	0	None	-8	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	475	13	2	4	3.9	NCCCN1CCN(CCCN(Cc2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL398980	154403	0	None	-8	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	475	13	2	4	3.9	NCCCN1CCN(CCCN(Cc2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2007.06.003
	71461662	79087	0	None	-4	4	Human	4.3	pKi	=	4.3	Binding	Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay	ChEMBL	442	9	4	3	3.2	NC(N)=NCCC[C@H](N)C(=O)N(Cc1cccc2ccccc12)Cc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00088-4
	CHEMBL2113280	79087	0	None	-4	4	Human	4.3	pKi	=	4.3	Binding	Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay	ChEMBL	442	9	4	3	3.2	NC(N)=NCCC[C@H](N)C(=O)N(Cc1cccc2ccccc12)Cc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00088-4
	44401607	133592	0	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	635	15	6	4	3.7	N=C(N)NCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCCCc1ccccc1	10.1016/j.bmcl.2005.03.120
	CHEMBL371366	133592	0	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	635	15	6	4	3.7	N=C(N)NCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCCCc1ccccc1	10.1016/j.bmcl.2005.03.120
	44413828	139268	0	None	-5	3	Human	6.3	pKi	=	6.3	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	632	12	5	5	4.0	N=C(N)NCCC[C@H]1C[C@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1Cc2ccccc2CN1	10.1021/jm060384p
	CHEMBL379168	139268	0	None	-5	3	Human	6.3	pKi	=	6.3	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	632	12	5	5	4.0	N=C(N)NCCC[C@H]1C[C@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1Cc2ccccc2CN1	10.1021/jm060384p
	10408	717	28	None	-23	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/jm201489a
	5329	717	28	None	-23	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/jm201489a
	9941379	717	28	None	-23	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/jm201489a
	CHEMBL2070241	717	28	None	-23	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/jm201489a
	DB11653	717	28	None	-23	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	10.1021/jm201489a
	44265711	206966	0	None	-3	4	Human	4.3	pKi	=	4.3	Binding	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptor	ChEMBL	343	6	3	2	3.5	NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00089-6
	CHEMBL9138	206966	0	None	-3	4	Human	4.3	pKi	=	4.3	Binding	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptor	ChEMBL	343	6	3	2	3.5	NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00089-6
	23653113	88623	0	None	-4	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	427	9	4	2	4.2	N=C(N)NCCCN(Cc1ccc2ccccc2c1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL235798	88623	0	None	-4	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	427	9	4	2	4.2	N=C(N)NCCCN(Cc1ccc2ccccc2c1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	137659790	159298	0	None	-102	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1728	21	21	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4099889	159298	0	None	-102	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1728	21	21	21	-3.2	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	44347840	161900	0	None	-17	3	Human	7.3	pKi	=	7.3	Binding	Inhibitory activity against human Melanocortin 3 receptor was determinedInhibitory activity against human Melanocortin 3 receptor was determined	ChEMBL	1590	33	17	23	-2.2	CC(=O)[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	91932630	161900	0	None	-17	3	Human	7.3	pKi	=	7.3	Binding	Inhibitory activity against human Melanocortin 3 receptor was determinedInhibitory activity against human Melanocortin 3 receptor was determined	ChEMBL	1590	33	17	23	-2.2	CC(=O)[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	CHEMBL415333	161900	0	None	-17	3	Human	7.3	pKi	=	7.3	Binding	Inhibitory activity against human Melanocortin 3 receptor was determinedInhibitory activity against human Melanocortin 3 receptor was determined	ChEMBL	1590	33	17	23	-2.2	CC(=O)[C@@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)CN2CCC[C@H]2C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(=O)O)C(N)=O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm030111j
	44322788	157359	0	None	-11	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	699	19	9	7	-0.2	CCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL407825	157359	0	None	-11	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	699	19	9	7	-0.2	CCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	44322957	206188	0	None	-8	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	753	19	10	7	0.6	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CC(F)(F)F)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL86573	206188	0	None	-8	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	753	19	10	7	0.6	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CC(F)(F)F)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	44432966	146276	0	None	-562	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]NDP-alphaMSH from human melanocortin 3 receptor expressed in CHOK1 cellsDisplacement of [125I]NDP-alphaMSH from human melanocortin 3 receptor expressed in CHOK1 cells	ChEMBL	560	14	0	6	6.7	COc1ccc(C(=O)c2nc3ccc(C(=O)N(CCC(C)C)CCC(C)C)cc3n2CCCN2CCCCC2)cc1	10.1016/j.bmcl.2007.06.010
	CHEMBL392092	146276	0	None	-562	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]NDP-alphaMSH from human melanocortin 3 receptor expressed in CHOK1 cellsDisplacement of [125I]NDP-alphaMSH from human melanocortin 3 receptor expressed in CHOK1 cells	ChEMBL	560	14	0	6	6.7	COc1ccc(C(=O)c2nc3ccc(C(=O)N(CCC(C)C)CCC(C)C)cc3n2CCCN2CCCCC2)cc1	10.1016/j.bmcl.2007.06.010
	44434649	145787	0	None	-2	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	453	12	2	2	6.4	NCCCCCN(/C=C/Cc1ccc2ccccc2c1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL391705	145787	0	None	-2	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	453	12	2	2	6.4	NCCCCCN(/C=C/Cc1ccc2ccccc2c1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434653	145790	0	None	-6	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	437	12	2	2	5.7	NCCCCCN(C/C(Cl)=C\c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL391706	145790	0	None	-6	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	437	12	2	2	5.7	NCCCCCN(C/C(Cl)=C\c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434787	148768	0	None	-1	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	729	13	3	5	9.1	COc1cc(Br)c(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)[C@H]2CC[C@@H](C[C@H]3CC[C@H](N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	CHEMBL394075	148768	0	None	-1	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	729	13	3	5	9.1	COc1cc(Br)c(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)[C@H]2CC[C@@H](C[C@H]3CC[C@H](N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	CHEMBL264352	210594	0	None	-104	4	Human	7.3	pKi	=	7.3	Binding	Inhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cellsInhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm0501432
	44434696	149174	0	None	-54	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	609	11	3	3	8.4	NC1CCC(CC2CCC(N(Cc3ccccc3F)C(=O)CCCc3c(Cc4ccc(O)cc4)[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL394394	149174	0	None	-54	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	609	11	3	3	8.4	NC1CCC(CC2CCC(N(Cc3ccccc3F)C(=O)CCCc3c(Cc4ccc(O)cc4)[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44409339	74967	0	None	-1479	3	Human	4.3	pKi	=	4.3	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	723	19	6	5	3.7	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC[C@H](Cc1ccccc1)NC(C)=O)Cc1ccc(F)cc1	10.1016/j.bmcl.2005.12.005
	CHEMBL203252	74967	0	None	-1479	3	Human	4.3	pKi	=	4.3	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	723	19	6	5	3.7	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC[C@H](Cc1ccccc1)NC(C)=O)Cc1ccc(F)cc1	10.1016/j.bmcl.2005.12.005
	44347119	114396	0	None	-151	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	752	9	10	7	0.5	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL333178	114396	0	None	-151	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	752	9	10	7	0.5	N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL322610	211211	0	None	-	1	Mouse	7.3	pKi	=	7.3	Binding	Binding constant (Ki) at mouse Melanocortin-3 receptorBinding constant (Ki) at mouse Melanocortin-3 receptor	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm010524p
	CHEMBL267900	210714	0	None	-144	4	Human	7.3	pKi	=	7.3	Binding	Inhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cellsInhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CSSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](CCC(=O)O)NC1=O	10.1021/jm0501432
	44400934	70584	0	None	-281	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	587	10	2	5	4.9	CN(C)C(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	CHEMBL194987	70584	0	None	-281	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	587	10	2	5	4.9	CN(C)C(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	44393418	155676	0	None	-5	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards Melanocortin 3 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 3 receptor using [125I]NDP-MSH	ChEMBL	589	8	2	7	3.2	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(C2(Cn3cncn3)CCCCC2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	CHEMBL405150	155676	0	None	-5	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards Melanocortin 3 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 3 receptor using [125I]NDP-MSH	ChEMBL	589	8	2	7	3.2	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(C2(Cn3cncn3)CCCCC2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	44265749	207199	0	None	-6	3	Human	4.3	pKi	=	4.3	Binding	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptor	ChEMBL	343	6	3	2	3.5	NC(=O)[C@H](Cc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00089-6
	CHEMBL9274	207199	0	None	-6	3	Human	4.3	pKi	=	4.3	Binding	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptor	ChEMBL	343	6	3	2	3.5	NC(=O)[C@H](Cc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00089-6
	10025669	97363	0	None	-79	4	Human	4.3	pKi	=	4.3	Binding	Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay	ChEMBL	429	11	5	4	3.0	NCCCNC(=O)[C@H](CNCc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00088-4
	CHEMBL269776	97363	0	None	-79	4	Human	4.3	pKi	=	4.3	Binding	Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay	ChEMBL	429	11	5	4	3.0	NCCCNC(=O)[C@H](CNCc1c[nH]c2ccccc12)NCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00088-4
	44400660	70701	0	None	-239	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	558	10	2	5	4.8	CC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	CHEMBL195071	70701	0	None	-239	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	558	10	2	5	4.8	CC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	44577090	178642	0	None	-57	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	502	9	2	4	4.0	CNCC(=O)N[C@H](c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1)C(C)C	10.1016/j.bmc.2008.03.072
	CHEMBL467771	178642	0	None	-57	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	502	9	2	4	4.0	CNCC(=O)N[C@H](c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1)C(C)C	10.1016/j.bmc.2008.03.072
	44434598	89787	0	None	-1	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	349	9	2	2	3.5	NCCCN(CCCc1ccccc1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237743	89787	0	None	-1	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	349	9	2	2	3.5	NCCCN(CCCc1ccccc1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434867	88494	0	None	-26	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	529	9	4	3	5.4	NC1CCCC(NC(=O)NC2CCCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C2)C1	10.1016/j.bmc.2007.06.003
	CHEMBL235162	88494	0	None	-26	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	529	9	4	3	5.4	NC1CCCC(NC(=O)NC2CCCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C2)C1	10.1016/j.bmc.2007.06.003
	44434790	90210	0	None	-3	3	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	399	7	4	2	3.4	N=C(N)NCCN(Cc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL238353	90210	0	None	-3	3	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	399	7	4	2	3.4	N=C(N)NCCN(Cc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44265309	205639	1	None	-1	3	Human	4.2	pKi	=	4.2	Binding	Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay	ChEMBL	214	5	2	2	2.3	NCCCNCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00088-4
	CHEMBL8201	205639	1	None	-1	3	Human	4.2	pKi	=	4.2	Binding	Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay	ChEMBL	214	5	2	2	2.3	NCCCNCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00088-4
	44400814	70592	0	None	-446	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	627	11	3	5	5.9	O=C(NC1CCCC1)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	CHEMBL194990	70592	0	None	-446	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	627	11	3	5	5.9	O=C(NC1CCCC1)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	44322987	96703	0	None	-15	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	713	20	9	7	0.2	CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL264306	96703	0	None	-15	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	713	20	9	7	0.2	CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	10158674	147890	0	None	-7	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	413	10	2	2	5.4	NCCCCCN(Cc1ccc2ccccc2c1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL393359	147890	0	None	-7	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	413	10	2	2	5.4	NCCCCCN(Cc1ccc2ccccc2c1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44265347	96938	0	None	-2	4	Human	4.2	pKi	=	4.2	Binding	Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay	ChEMBL	426	10	4	4	3.3	NCCNC(=O)[C@H](CNCc1ccc2ccccc2c1)NCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00088-4
	CHEMBL266305	96938	0	None	-2	4	Human	4.2	pKi	=	4.2	Binding	Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay	ChEMBL	426	10	4	4	3.3	NCCNC(=O)[C@H](CNCc1ccc2ccccc2c1)NCc1ccc2ccccc2c1	10.1016/s0960-894x(02)00088-4
	23635235	166477	0	None	-177	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	526	10	1	4	4.9	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1016/j.bmc.2008.03.072
	CHEMBL427860	166477	0	None	-177	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	526	10	1	4	4.9	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1016/j.bmc.2008.03.072
	44347110	114082	0	None	-6	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	681	9	9	7	0.6	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NCC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL332762	114082	0	None	-6	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	681	9	9	7	0.6	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NCC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	44347082	163884	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	766	9	10	7	0.9	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL420727	163884	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	766	9	10	7	0.9	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	44347330	168039	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	766	9	10	7	0.9	N=C(N)NCCC[C@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL432407	168039	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	766	9	10	7	0.9	N=C(N)NCCC[C@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	44347081	168603	0	None	-4	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	766	9	10	7	0.9	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	CHEMBL436169	168603	0	None	-4	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding)	ChEMBL	766	9	10	7	0.9	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm010165y
	44434864	90220	0	None	-21	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	529	9	4	3	5.4	N[C@H]1CC[C@H](NC(=O)NC2CCCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL238369	90220	0	None	-21	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	529	9	4	3	5.4	N[C@H]1CC[C@H](NC(=O)NC2CCCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C2)CC1	10.1016/j.bmc.2007.06.003
	2852098	205441	13	None	-4	3	Human	4.2	pKi	=	4.2	Binding	Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay	ChEMBL	300	5	2	1	4.7	c1ccc2cc(CNCCc3c[nH]c4ccccc34)ccc2c1	10.1016/s0960-894x(02)00088-4
	CHEMBL8045	205441	13	None	-4	3	Human	4.2	pKi	=	4.2	Binding	Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay	ChEMBL	300	5	2	1	4.7	c1ccc2cc(CNCCc3c[nH]c4ccccc34)ccc2c1	10.1016/s0960-894x(02)00088-4
	CHEMBL439128	213802	0	None	-2	3	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@@H]1CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC1=O	10.1021/jm030119t
	CHEMBL412523	212977	0	None	-22	4	Human	8.2	pKi	=	8.2	Binding	Inhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cellsInhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm0501432
	44434639	148133	0	None	-3	3	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	405	13	2	2	5.1	NCCCCCN(CCCc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL393557	148133	0	None	-3	3	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	405	13	2	2	5.1	NCCCCCN(CCCc1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44416014	79986	0	None	-16	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	562	10	4	5	1.3	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCNC(N)=O)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL212855	79986	0	None	-16	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	562	10	4	5	1.3	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCNC(N)=O)C1=O	10.1016/j.bmcl.2006.05.087
	44409338	168720	0	None	-1230	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	739	19	7	6	3.4	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC[C@H](Cc1ccc(O)cc1)NC(C)=O)Cc1ccc(F)cc1	10.1016/j.bmcl.2005.12.005
	CHEMBL437132	168720	0	None	-1230	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity to MC3 receptorBinding affinity to MC3 receptor	ChEMBL	739	19	7	6	3.4	CNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC[C@H](Cc1ccc(O)cc1)NC(C)=O)Cc1ccc(F)cc1	10.1016/j.bmcl.2005.12.005
	44434778	89714	0	None	-27	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	544	9	1	3	7.8	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)COc3ccc4ccccc4c3)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL237702	89714	0	None	-27	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	544	9	1	3	7.8	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)COc3ccc4ccccc4c3)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434853	97175	0	None	-5	2	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	415	8	2	2	5.3	N[C@@H]1CCCC[C@H]1N(C/C=C/c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL268395	97175	0	None	-5	2	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	415	8	2	2	5.3	N[C@@H]1CCCC[C@H]1N(C/C=C/c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	11215758	66049	0	None	-131	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human melanocortin 3 receptorBinding affinity for human melanocortin 3 receptor	ChEMBL	624	9	3	6	5.0	CC(NC1CCCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)c2cnc3ccccc3c2)CC1	10.1016/j.bmcl.2004.10.096
	CHEMBL183799	66049	0	None	-131	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human melanocortin 3 receptorBinding affinity for human melanocortin 3 receptor	ChEMBL	624	9	3	6	5.0	CC(NC1CCCNC1)c1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)c2cnc3ccccc3c2)CC1	10.1016/j.bmcl.2004.10.096
	44322924	107085	0	None	-5	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	701	19	11	8	-1.4	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL316038	107085	0	None	-5	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	701	19	11	8	-1.4	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL3577977	211722	0	None	-3	2	Mouse	6.2	pKi	=	6.2	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O)[C@@H](C)O)[C@@H](C)O	10.1021/acs.jmedchem.5b00184
	CHEMBL3577978	211723	0	None	-10	2	Mouse	6.2	pKi	=	6.2	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@H](C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CSSC[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC1=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2)[C@@H](C)O	10.1021/acs.jmedchem.5b00184
	CHEMBL3577982	211727	0	None	-3	2	Mouse	6.2	pKi	=	6.2	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	10177247	89485	0	None	-5	3	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	371	7	2	2	4.2	NCCCN(Cc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237314	89485	0	None	-5	3	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	371	7	2	2	4.2	NCCCN(Cc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	10200110	89704	0	None	-4	3	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	385	8	2	2	4.6	NCCCCN(Cc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237687	89704	0	None	-4	3	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	385	8	2	2	4.6	NCCCCN(Cc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434605	149490	0	None	-9	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	356	10	1	3	4.4	C/C(=C\c1ccccc1)CN(CCCN)C(=O)CCCc1cccs1	10.1016/j.bmc.2007.06.003
	CHEMBL394647	149490	0	None	-9	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	356	10	1	3	4.4	C/C(=C\c1ccccc1)CN(CCCN)C(=O)CCCc1cccs1	10.1016/j.bmc.2007.06.003
	168277258	190686	0	None	-109	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	1243	15	14	15	-0.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSSCC[C@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5182345	190686	0	None	-109	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	1243	15	14	15	-0.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSSCC[C@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	6918814	127031	1	None	-134	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	587	12	3	6	4.1	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	CHEMBL365597	127031	1	None	-134	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	587	12	3	6	4.1	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	44433264	89322	0	None	-144	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]NDP-MSH from MC3R receptor in HEK293 cellsDisplacement of [125I]NDP-MSH from MC3R receptor in HEK293 cells	ChEMBL	598	8	1	4	5.9	CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmc.2007.05.026
	CHEMBL236940	89322	0	None	-144	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]NDP-MSH from MC3R receptor in HEK293 cellsDisplacement of [125I]NDP-MSH from MC3R receptor in HEK293 cells	ChEMBL	598	8	1	4	5.9	CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmc.2007.05.026
	6918814	127031	1	None	-134	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [125]NDP-MSH from human MC3receptor expressed in HEK293 cellsDisplacement of [125]NDP-MSH from human MC3receptor expressed in HEK293 cells	ChEMBL	587	12	3	6	4.1	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1021/jm049278i
	CHEMBL365597	127031	1	None	-134	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [125]NDP-MSH from human MC3receptor expressed in HEK293 cellsDisplacement of [125]NDP-MSH from human MC3receptor expressed in HEK293 cells	ChEMBL	587	12	3	6	4.1	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1021/jm049278i
	44265639	10147	0	None	-5	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptor	ChEMBL	439	9	4	3	4.1	NC(N)=NCCC[C@H](NCc1ccc2ccccc2c1)C(=O)Nc1cccc2ccccc12	10.1016/s0960-894x(02)00089-6
	CHEMBL1159697	10147	0	None	-5	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptor	ChEMBL	439	9	4	3	4.1	NC(N)=NCCC[C@H](NCc1ccc2ccccc2c1)C(=O)Nc1cccc2ccccc12	10.1016/s0960-894x(02)00089-6
	44434854	90000	0	None	-8	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	573	10	2	2	8.6	CC1CC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	CHEMBL238153	90000	0	None	-8	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	573	10	2	2	8.6	CC1CC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	44323031	168054	0	None	-10	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	775	21	10	7	1.2	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL432565	168054	0	None	-10	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	775	21	10	7	1.2	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	44397028	124005	0	None	-85	4	Human	6.2	pKi	=	6.2	Binding	Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells	ChEMBL	631	12	3	6	3.6	COc1cccc(CC(=O)NCC2(N3CCN(C(=O)[C@@H](Cc4ccc(Cl)cc4Cl)NC(=O)CCN)CC3)CCCCC2)c1	10.1016/j.bmcl.2005.05.017
	CHEMBL363019	124005	0	None	-85	4	Human	6.2	pKi	=	6.2	Binding	Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells	ChEMBL	631	12	3	6	3.6	COc1cccc(CC(=O)NCC2(N3CCN(C(=O)[C@@H](Cc4ccc(Cl)cc4Cl)NC(=O)CCN)CC3)CCCCC2)c1	10.1016/j.bmcl.2005.05.017
	44392514	123841	0	None	-7	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards Melanocortin 3 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 3 receptor using [125I]NDP-MSH	ChEMBL	575	7	2	7	3.0	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN([C@H]2CCCC[C@@H]2n2cncn2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	CHEMBL362670	123841	0	None	-7	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards Melanocortin 3 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 3 receptor using [125I]NDP-MSH	ChEMBL	575	7	2	7	3.0	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN([C@H]2CCCC[C@@H]2n2cncn2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	44434794	88491	0	None	-4	3	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	413	8	4	2	3.8	N=C(N)NCCN(Cc1ccc2ccccc2c1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL235147	88491	0	None	-4	3	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	413	8	4	2	3.8	N=C(N)NCCN(Cc1ccc2ccccc2c1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434600	148578	0	None	-5	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	361	9	2	2	4.0	NCCCN(C/C=C/c1ccccc1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL393918	148578	0	None	-5	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	361	9	2	2	4.0	NCCCN(C/C=C/c1ccccc1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44434771	148766	0	None	-30	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	627	11	3	3	8.6	NC1CCC(CC2CCC(N(Cc3c(F)cccc3F)C(=O)CCCc3c(Cc4ccc(O)cc4)[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL394073	148766	0	None	-30	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	627	11	3	3	8.6	NC1CCC(CC2CCC(N(Cc3c(F)cccc3F)C(=O)CCCc3c(Cc4ccc(O)cc4)[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434572	166568	0	None	-11	3	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	395	9	2	2	4.6	NCCN(C/C(Cl)=C/c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL428022	166568	0	None	-11	3	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	395	9	2	2	4.6	NCCN(C/C(Cl)=C/c1ccccc1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44401367	161695	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	602	13	5	4	3.4	N=C(N)NCCC[C@H](NC(=O)Cc1ccc(Cl)cc1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	CHEMBL413565	161695	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	602	13	5	4	3.4	N=C(N)NCCC[C@H](NC(=O)Cc1ccc(Cl)cc1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	44323032	206581	0	None	-3	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	761	20	10	7	0.8	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	CHEMBL89004	206581	0	None	-3	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL	761	20	10	7	0.8	N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	44434855	90001	0	None	-10	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	7.5	CC1CC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	CHEMBL238154	90001	0	None	-10	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	513	9	2	2	7.5	CC1CC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)C(C)C2)CCC1N	10.1016/j.bmc.2007.06.003
	57817730	76894	0	None	-338	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1919	56	24	26	-3.5	CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	70684622	76894	0	None	-338	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1919	56	24	26	-3.5	CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	91929805	76894	0	None	-338	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1919	56	24	26	-3.5	CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	CHEMBL2070247	76894	0	None	-338	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1919	56	24	26	-3.5	CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	44400935	70833	0	None	-446	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	613	10	2	5	5.5	O=C(N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)N1CCCC1	10.1016/j.bmcl.2005.03.053
	CHEMBL195110	70833	0	None	-446	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	613	10	2	5	5.5	O=C(N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)N1CCCC1	10.1016/j.bmcl.2005.03.053
	44434632	146284	0	None	-8	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	375	10	2	2	4.4	NCCCCN(C/C=C/c1ccccc1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL392096	146284	0	None	-8	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	375	10	2	2	4.4	NCCCCN(C/C=C/c1ccccc1)C(=O)CCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL410168	212781	0	None	-3	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H]1CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC1=O	10.1021/jm030119t
	44393421	123077	0	None	-4	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards Melanocortin 3 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 3 receptor using [125I]NDP-MSH	ChEMBL	508	6	2	4	3.6	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(C2CCCCC2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	CHEMBL361052	123077	0	None	-4	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards Melanocortin 3 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 3 receptor using [125I]NDP-MSH	ChEMBL	508	6	2	4	3.6	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(C2CCCCC2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	70684954	77790	0	None	-7	3	Human	4.2	pKi	=	4.2	Binding	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptor	ChEMBL	383	5	2	2	4.6	O=C(NCc1c[nH]c2ccccc12)[C@@H]1CCCN1Cc1cccc2ccccc12	10.1016/s0960-894x(02)00089-6
	CHEMBL2092821	77790	0	None	-7	3	Human	4.2	pKi	=	4.2	Binding	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptor	ChEMBL	383	5	2	2	4.6	O=C(NCc1c[nH]c2ccccc12)[C@@H]1CCCN1Cc1cccc2ccccc12	10.1016/s0960-894x(02)00089-6
	9924916	88980	0	None	-3	3	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	357	6	2	2	3.9	NCCN(Cc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL236447	88980	0	None	-3	3	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	357	6	2	2	3.9	NCCN(Cc1ccc2ccccc2c1)C(=O)Cc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	168279695	191111	0	None	-2	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	2967	66	33	39	-5.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N2)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5188196	191111	0	None	-2	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	2967	66	33	39	-5.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N2)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	1334	1489	7	None	1	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		None	10.1021/jm030119t
	16133814	1489	7	None	1	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		None	10.1021/jm030119t
	CHEMBL437050	1489	7	None	1	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement.	ChEMBL		None	None	None		None	10.1021/jm030119t
	44401581	68601	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	602	13	5	4	3.4	N=C(N)NCCC[C@H](NC(=O)Cc1ccccc1Cl)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	CHEMBL191794	68601	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	602	13	5	4	3.4	N=C(N)NCCC[C@H](NC(=O)Cc1ccccc1Cl)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	44416106	141421	0	None	-5	3	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	617	12	4	5	1.5	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL384176	141421	0	None	-5	3	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	617	12	4	5	1.5	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@@H](Cc2ccc(F)cc2)NC(C)=O)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	44323020	168972	0	None	7	3	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsBinding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	951	11	12	9	1.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)c2ccccc2C(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL439188	168972	0	None	7	3	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsBinding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	951	11	12	9	1.5	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)c2ccccc2C(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL2373515	210356	0	None	-15	3	Human	8.1	pKi	=	8.1	Binding	Inhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cellsInhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(=O)N[C@@H](CO)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm0501432
	11226756	119948	0	None	-114	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards human Melanocortin 3 receptor (MC3R) using [125I]NDP-alpha-MSH as a radioligand in membranes of HEK 293 cellsBinding affinity towards human Melanocortin 3 receptor (MC3R) using [125I]NDP-alpha-MSH as a radioligand in membranes of HEK 293 cells	ChEMBL	559	8	2	5	3.5	CN(C)Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1021/jm0304109
	CHEMBL349850	119948	0	None	-114	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards human Melanocortin 3 receptor (MC3R) using [125I]NDP-alpha-MSH as a radioligand in membranes of HEK 293 cellsBinding affinity towards human Melanocortin 3 receptor (MC3R) using [125I]NDP-alpha-MSH as a radioligand in membranes of HEK 293 cells	ChEMBL	559	8	2	5	3.5	CN(C)Cc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1021/jm0304109
	6918857	138684	1	None	-239	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cell	ChEMBL	619	11	2	5	4.4	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.10.103
	CHEMBL377961	138684	1	None	-239	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cellDisplacement of [125I]NDP-alpha-MSH from cloned human MC3R expressed in HEK293 cell	ChEMBL	619	11	2	5	4.4	CCN(CC)CC(c1ccccc1F)N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1016/j.bmcl.2005.10.103
	44413880	77917	0	None	-46	3	Human	6.2	pKi	=	6.2	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	639	14	6	7	0.7	NC(N)=NCCNC(=O)[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]cn1	10.1021/jm060384p
	CHEMBL209587	77917	0	None	-46	3	Human	6.2	pKi	=	6.2	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	639	14	6	7	0.7	NC(N)=NCCNC(=O)[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]cn1	10.1021/jm060384p
	44401587	10269	0	None	1	2	Human	5.2	pKi	=	5.2	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	611	15	6	5	2.6	N=C(N)NCCC[C@H](NC(=O)CCc1ccccc1CN)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	CHEMBL1161794	10269	0	None	1	2	Human	5.2	pKi	=	5.2	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	611	15	6	5	2.6	N=C(N)NCCC[C@H](NC(=O)CCc1ccccc1CN)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	CHEMBL5094215	215458	0	None	-60	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](C)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL2070374	209164	0	None	-123	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@H](CNC(=O)CN(CC(=O)O)CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCc1nnn[nH]1)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	23635236	91572	0	None	-123	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]NDP-MSH from human MC3RDisplacement of [125I]NDP-MSH from human MC3R	ChEMBL	512	10	2	4	4.6	CNCCC(=O)N[C@H](c1cc(C)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1)C(C)C	10.1021/jm070806a
	CHEMBL240780	91572	0	None	-123	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]NDP-MSH from human MC3RDisplacement of [125I]NDP-MSH from human MC3R	ChEMBL	512	10	2	4	4.6	CNCCC(=O)N[C@H](c1cc(C)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1)C(C)C	10.1021/jm070806a
	23635236	91572	0	None	-123	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	512	10	2	4	4.6	CNCCC(=O)N[C@H](c1cc(C)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1)C(C)C	10.1016/j.bmc.2008.03.072
	CHEMBL240780	91572	0	None	-123	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	512	10	2	4	4.6	CNCCC(=O)N[C@H](c1cc(C)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1)C(C)C	10.1016/j.bmc.2008.03.072
	24180592	96984	0	None	-208	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]NDPMSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC3R expressed in HEK293 cells	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
	CHEMBL266647	96984	0	None	-208	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]NDPMSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC3R expressed in HEK293 cells	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
	44397198	66735	0	None	-93	3	Human	6.2	pKi	=	6.2	Binding	Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells	ChEMBL	601	11	3	5	3.6	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(C2(CNC(=O)Cc3ccccc3)CCCCC2)CC1	10.1016/j.bmcl.2005.05.017
	CHEMBL185862	66735	0	None	-93	3	Human	6.2	pKi	=	6.2	Binding	Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells	ChEMBL	601	11	3	5	3.6	NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(C2(CNC(=O)Cc3ccccc3)CCCCC2)CC1	10.1016/j.bmcl.2005.05.017
	44434690	89277	0	None	-19	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	545	10	2	2	8.1	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL236861	89277	0	None	-19	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	545	10	2	2	8.1	NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44413832	78036	0	None	-4	3	Human	5.1	pKi	=	5.1	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	584	12	5	5	3.5	N=C(N)NCCC[C@@H]1C[C@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCCCN1	10.1021/jm060384p
	CHEMBL210009	78036	0	None	-4	3	Human	5.1	pKi	=	5.1	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	584	12	5	5	3.5	N=C(N)NCCC[C@@H]1C[C@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCCCN1	10.1021/jm060384p
	11845804	79529	0	None	-1548	3	Human	5.1	pKi	=	5.1	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	652	15	5	6	2.6	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL211419	79529	0	None	-1548	3	Human	5.1	pKi	=	5.1	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	652	15	5	6	2.6	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@H]1CCCN=C(N)N	10.1021/jm060384p
	25133907	176700	0	None	-9	3	Human	6.1	pKi	=	6.1	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	518	9	2	4	3.0	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@H](N)Cc1ccc(F)cc1	10.1021/jm800525p
	CHEMBL460138	176700	0	None	-9	3	Human	6.1	pKi	=	6.1	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	518	9	2	4	3.0	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@H](N)Cc1ccc(F)cc1	10.1021/jm800525p
	1338	3778	43	None	-75	4	Human	6.1	pKi	=	6.1	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2005.03.120
	9938402	3778	43	None	-75	4	Human	6.1	pKi	=	6.1	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2005.03.120
	CHEMBL339053	3778	43	None	-75	4	Human	6.1	pKi	=	6.1	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	588	8	2	6	4.6	O=C([C@@H]1NCc2c(C1)cccc2)N[C@@H](C(=O)N1CCC(CC1)(Cn1cncn1)C1CCCCC1)Cc1ccc(cc1)Cl	10.1016/j.bmcl.2005.03.120
	10178845	89885	0	None	-7	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	395	8	2	3	3.8	NCCCN(C/C(Cl)=C/c1ccccc1)C(=O)C(=O)c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL237937	89885	0	None	-7	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	395	8	2	3	3.8	NCCCN(C/C(Cl)=C/c1ccccc1)C(=O)C(=O)c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44413969	80201	0	None	-21	3	Human	5.1	pKi	=	5.1	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	584	12	5	5	3.5	N=C(N)NCCC[C@@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCCCN1	10.1021/jm060384p
	CHEMBL213752	80201	0	None	-21	3	Human	5.1	pKi	=	5.1	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	584	12	5	5	3.5	N=C(N)NCCC[C@@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCCCN1	10.1021/jm060384p
	44415912	139201	0	None	-10	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	575	11	4	5	1.3	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	CHEMBL378837	139201	0	None	-10	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human MC3RBinding affinity to human MC3R	ChEMBL	575	11	4	5	1.3	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCCN=C(N)N)C1=O	10.1016/j.bmcl.2006.05.087
	24180646	148158	0	None	-1071	8	Human	6.1	pKi	=	6.1	Binding	Binding affinity at human MC3RBinding affinity at human MC3R	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmcl.2007.07.097
	CHEMBL393576	148158	0	None	-1071	8	Human	6.1	pKi	=	6.1	Binding	Binding affinity at human MC3RBinding affinity at human MC3R	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmcl.2007.07.097
	24180646	148158	0	None	-1071	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]NDPMSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC3R expressed in HEK293 cells	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1021/jm701137s
	CHEMBL393576	148158	0	None	-1071	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]NDPMSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC3R expressed in HEK293 cells	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1021/jm701137s
	44434821	89999	0	None	-3	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	441	10	4	2	4.5	N=C(N)NCCCN(Cc1ccc2ccccc2c1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL238149	89999	0	None	-3	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	441	10	4	2	4.5	N=C(N)NCCCN(Cc1ccc2ccccc2c1)C(=O)CCCc1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	137647538	157938	0	None	-1318	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1680	20	21	21	-3.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	CHEMBL4084765	157938	0	None	-1318	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proximity assay	ChEMBL	1680	20	21	21	-3.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.8b00170
	25131478	169484	0	None	-53	3	Human	7.1	pKi	=	7.1	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	574	10	5	6	1.1	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](C/C=N/NC(=N)N)C1=O	10.1021/jm800525p
	CHEMBL443396	169484	0	None	-53	3	Human	7.1	pKi	=	7.1	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	574	10	5	6	1.1	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](C/C=N/NC(=N)N)C1=O	10.1021/jm800525p
	44443035	154393	0	None	-1258	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to MC3RBinding affinity to MC3R	ChEMBL	584	9	1	5	5.5	COc1ccc(CNCC2(N3CCN(C(=O)[C@H]4CN(C(C)C)C[C@@H]4c4ccc(Cl)cc4)CC3)CCCCC2)cc1F	10.1016/j.bmcl.2007.10.032
	CHEMBL398929	154393	0	None	-1258	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to MC3RBinding affinity to MC3R	ChEMBL	584	9	1	5	5.5	COc1ccc(CNCC2(N3CCN(C(=O)[C@H]4CN(C(C)C)C[C@@H]4c4ccc(Cl)cc4)CC3)CCCCC2)cc1F	10.1016/j.bmcl.2007.10.032
	44322795	206903	0	None	-13	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsBinding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	853	11	12	9	-0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL91041	206903	0	None	-13	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsBinding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells	ChEMBL	853	11	12	9	-0.8	N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CCC(=O)NCCCC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm020021z
	CHEMBL50056	214096	2	None	-41	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1016/s0960-894x(03)00552-3
	46905544	10267	0	None	4	2	Human	5.1	pKi	=	5.1	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	641	14	6	5	2.6	CC(N)=O.N=C(N)NCCC[C@H](NC(=O)CCc1ccccc1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	CHEMBL1161791	10267	0	None	4	2	Human	5.1	pKi	=	5.1	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	641	14	6	5	2.6	CC(N)=O.N=C(N)NCCC[C@H](NC(=O)CCc1ccccc1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	44434702	149489	0	None	-26	4	Human	4.1	pKi	=	4.1	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	605	11	3	3	8.6	Cc1cccc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)c1	10.1016/j.bmc.2007.06.003
	CHEMBL394646	149489	0	None	-26	4	Human	4.1	pKi	=	4.1	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	605	11	3	3	8.6	Cc1cccc(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)c1	10.1016/j.bmc.2007.06.003
	44434856	154368	0	None	-16	4	Human	4.1	pKi	=	4.1	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	535	14	2	4	5.0	NCCCN1CCN(CCCN(C/C(Cl)=C/c2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL398777	154368	0	None	-16	4	Human	4.1	pKi	=	4.1	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	535	14	2	4	5.0	NCCCN1CCN(CCCN(C/C(Cl)=C/c2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2007.06.003
	44400864	124299	0	None	-467	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	587	11	3	5	5.0	CCNC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	CHEMBL363576	124299	0	None	-467	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	587	11	3	5	5.0	CCNC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	6918844	168598	1	None	-245	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	606	12	2	6	5.3	O=C(N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)OCCF	10.1016/j.bmcl.2005.03.053
	CHEMBL436122	168598	1	None	-245	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	606	12	2	6	5.3	O=C(N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1)OCCF	10.1016/j.bmcl.2005.03.053
	122178157	121226	0	None	-50	2	Mouse	6.1	pKi	=	6.1	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL	1027	12	10	10	-0.1	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)C(Cc2cccc3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	CHEMBL3577986	121226	0	None	-50	2	Mouse	6.1	pKi	=	6.1	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL	1027	12	10	10	-0.1	C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)C(Cc2cccc3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O	10.1021/acs.jmedchem.5b00184
	CHEMBL3577976	211721	0	None	-2	2	Mouse	6.1	pKi	=	6.1	Binding	Displacement of MTII from mouse MC3R expressed in HEK293 cellsDisplacement of MTII from mouse MC3R expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O)[C@@H](C)O	10.1021/acs.jmedchem.5b00184
	44265496	97020	0	None	-13	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards Melanocortin 3 receptor, expressed as negative log of the Ki valueBinding affinity towards Melanocortin 3 receptor, expressed as negative log of the Ki value	ChEMBL	453	9	3	3	3.9	NC(N)=NCCC[C@H](N)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12	10.1021/jm020945m
	CHEMBL267020	97020	0	None	-13	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards Melanocortin 3 receptor, expressed as negative log of the Ki valueBinding affinity towards Melanocortin 3 receptor, expressed as negative log of the Ki value	ChEMBL	453	9	3	3	3.9	NC(N)=NCCC[C@H](N)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12	10.1021/jm020945m
	70688853	76895	0	None	-23	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1495	39	18	16	-0.1	CCCCCCCCCCCCCCCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	CHEMBL2070248	76895	0	None	-23	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1495	39	18	16	-0.1	CCCCCCCCCCCCCCCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	57646437	76893	0	None	-74	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1855	51	23	23	-2.2	CCCCCCCCCCCCCCCC(=O)NS(=O)(=O)CCCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	70684621	76893	0	None	-74	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1855	51	23	23	-2.2	CCCCCCCCCCCCCCCC(=O)NS(=O)(=O)CCCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	91929804	76893	0	None	-74	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1855	51	23	23	-2.2	CCCCCCCCCCCCCCCC(=O)NS(=O)(=O)CCCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	CHEMBL2070246	76893	0	None	-74	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminDisplacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbumin	ChEMBL	1855	51	23	23	-2.2	CCCCCCCCCCCCCCCC(=O)NS(=O)(=O)CCCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O	10.1021/jm201489a
	162669632	182541	0	None	-6	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3ccc4ccccc4c3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4787753	182541	0	None	-6	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3ccc4ccccc4c3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	162669632	182541	0	None	-6	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3ccc4ccccc4c3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	CHEMBL4787753	182541	0	None	-6	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsDisplacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins	ChEMBL	1150	18	14	11	1.8	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(-c3ccc4ccccc4c3)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O	10.1021/acs.jmedchem.0c01620
	25129453	171742	0	None	-14	3	Human	7.1	pKi	=	7.1	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	677	11	3	5	3.9	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@@H]1Cc2ccccc2CN1	10.1021/jm800525p
	CHEMBL446757	171742	0	None	-14	3	Human	7.1	pKi	=	7.1	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	677	11	3	5	3.9	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@@H]1Cc2ccccc2CN1	10.1021/jm800525p
	44400932	70274	0	None	-173	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	588	11	2	6	5.4	CCOC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	CHEMBL194393	70274	0	None	-173	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	588	11	2	6	5.4	CCOC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	16007285	81093	0	None	-61	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	586	10	2	4	5.8	CCC(C)[C@H](NC(=O)CCN)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)CCc2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2006.05.088
	CHEMBL215659	81093	0	None	-61	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDP-MSH from human MC3R expressed in HEK293 cells	ChEMBL	586	10	2	4	5.8	CCC(C)[C@H](NC(=O)CCN)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)CCc2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2006.05.088
	44434709	89746	0	None	-21	4	Human	4.1	pKi	=	4.1	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	563	9	2	2	7.7	NC1CCC(CC2CCC(N(Cc3ccccc3Br)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL237714	89746	0	None	-21	4	Human	4.1	pKi	=	4.1	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	563	9	2	2	7.7	NC1CCC(CC2CCC(N(Cc3ccccc3Br)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44400778	135863	0	None	-162	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	574	10	2	6	5.0	COC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	CHEMBL373099	135863	0	None	-162	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	574	10	2	6	5.0	COC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	44434785	148767	0	None	-3	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	623	11	2	4	7.8	COc1cc(Br)c(CN(C(=O)CCCc2c[nH]c3ccccc23)[C@H]2CC[C@@H](C[C@H]3CC[C@@H](N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	CHEMBL394074	148767	0	None	-3	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	623	11	2	4	7.8	COc1cc(Br)c(CN(C(=O)CCCc2c[nH]c3ccccc23)[C@H]2CC[C@@H](C[C@H]3CC[C@@H](N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	44413968	80200	0	None	-426	3	Human	5.1	pKi	=	5.1	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	632	12	5	5	4.0	N=C(N)NCCC[C@@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1Cc2ccccc2CN1	10.1021/jm060384p
	CHEMBL213751	80200	0	None	-426	3	Human	5.1	pKi	=	5.1	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	632	12	5	5	4.0	N=C(N)NCCC[C@@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)C1Cc2ccccc2CN1	10.1021/jm060384p
	24740655	89057	0	None	-1380	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity at human MC3RBinding affinity at human MC3R	ChEMBL	643	12	1	5	5.3	Cc1ccc(N2CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3Cl)N3CCCC3=O)CC2)c([C@H](CC(C)C)NC(=O)CCN(C)C)c1	10.1016/j.bmcl.2007.07.097
	CHEMBL236521	89057	0	None	-1380	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity at human MC3RBinding affinity at human MC3R	ChEMBL	643	12	1	5	5.3	Cc1ccc(N2CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3Cl)N3CCCC3=O)CC2)c([C@H](CC(C)C)NC(=O)CCN(C)C)c1	10.1016/j.bmcl.2007.07.097
	24740655	89057	0	None	-1380	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]NDPMSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC3R expressed in HEK293 cells	ChEMBL	643	12	1	5	5.3	Cc1ccc(N2CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3Cl)N3CCCC3=O)CC2)c([C@H](CC(C)C)NC(=O)CCN(C)C)c1	10.1021/jm701137s
	CHEMBL236521	89057	0	None	-1380	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]NDPMSH from human MC3R expressed in HEK293 cellsDisplacement of [125I]NDPMSH from human MC3R expressed in HEK293 cells	ChEMBL	643	12	1	5	5.3	Cc1ccc(N2CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3Cl)N3CCCC3=O)CC2)c([C@H](CC(C)C)NC(=O)CCN(C)C)c1	10.1021/jm701137s
	58777892	79015	0	None	-117	4	Human	5.1	pKi	=	5.1	Binding	Inhibition of [125I]-NDP MSH binding towards human melanocortin 3 receptorInhibition of [125I]-NDP MSH binding towards human melanocortin 3 receptor	ChEMBL	599	7	2	5	3.9	CN(C)C1CCc2cccc(N3CCN(C(=O)[C@@H](Cc4ccc(Cl)cc4)NC(=O)[C@H]4Cc5ccccc5CN4)CC3)c2C1	10.1016/j.bmcl.2005.07.035
	CHEMBL2113149	79015	0	None	-117	4	Human	5.1	pKi	=	5.1	Binding	Inhibition of [125I]-NDP MSH binding towards human melanocortin 3 receptorInhibition of [125I]-NDP MSH binding towards human melanocortin 3 receptor	ChEMBL	599	7	2	5	3.9	CN(C)C1CCc2cccc(N3CCN(C(=O)[C@@H](Cc4ccc(Cl)cc4)NC(=O)[C@H]4Cc5ccccc5CN4)CC3)c2C1	10.1016/j.bmcl.2005.07.035
	44265681	10151	0	None	-28	2	Human	4.1	pKi	=	4.1	Binding	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptor	ChEMBL	369	7	4	4	0.6	NC(N)=NCCCNC(=O)[C@@H]1C[C@H](O)CN1Cc1ccc2ccccc2c1	10.1016/s0960-894x(02)00089-6
	CHEMBL1159700	10151	0	None	-28	2	Human	4.1	pKi	=	4.1	Binding	Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptorBinding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 3 receptor	ChEMBL	369	7	4	4	0.6	NC(N)=NCCCNC(=O)[C@@H]1C[C@H](O)CN1Cc1ccc2ccccc2c1	10.1016/s0960-894x(02)00089-6
	44413879	138877	0	None	-64	3	Human	6.1	pKi	=	6.1	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	681	15	6	7	0.9	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1C(=O)NCCN=C(N)N	10.1021/jm060384p
	CHEMBL378293	138877	0	None	-64	3	Human	6.1	pKi	=	6.1	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	681	15	6	7	0.9	CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@@H]1C(=O)NCCN=C(N)N	10.1021/jm060384p
	25132526	188899	0	None	-43	3	Human	6.1	pKi	=	6.1	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	602	10	2	4	4.2	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C(C)(C)C	10.1021/jm800525p
	CHEMBL507876	188899	0	None	-43	3	Human	6.1	pKi	=	6.1	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	602	10	2	4	4.2	CCC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C(C)(C)C	10.1021/jm800525p
	168279695	191111	0	None	-2	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	2967	66	33	39	-5.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N2)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5188196	191111	0	None	-2	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	2967	66	33	39	-5.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N2)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	44400777	68643	0	None	-295	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	630	13	2	7	4.7	COC(=O)CCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	CHEMBL192090	68643	0	None	-295	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	630	13	2	7	4.7	COC(=O)CCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	44434763	151319	0	None	-13	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	685	13	3	5	9.0	COc1cc(Cl)c(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	CHEMBL396111	151319	0	None	-13	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	685	13	3	5	9.0	COc1cc(Cl)c(CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	168285904	191646	0	None	-169	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	1347	15	14	15	1.3	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSCc2cccc(c2)CSCC[C@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5196407	191646	0	None	-169	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	1347	15	14	15	1.3	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](NC(C)=O)CCSCc2cccc(c2)CSCC[C@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	44413830	77921	0	None	-8	3	Human	6.1	pKi	=	6.1	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	587	14	5	6	1.3	NC(=O)C[C@H](N)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL209622	77921	0	None	-8	3	Human	6.1	pKi	=	6.1	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	587	14	5	6	1.3	NC(=O)C[C@H](N)C(=O)N[C@H](Cc1ccccc1)C(=O)N1C[C@@H](OCc2ccc3ccccc3c2)C[C@@H]1CCCN=C(N)N	10.1021/jm060384p
	CHEMBL5083551	214846	0	None	-93	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](C)C(=O)N2	10.1021/acs.jmedchem.1c00095
	11845272	80329	0	None	-8	3	Human	7.1	pKi	=	7.1	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	632	12	5	5	4.0	N=C(N)NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1	10.1021/jm060384p
	CHEMBL214347	80329	0	None	-8	3	Human	7.1	pKi	=	7.1	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	632	12	5	5	4.0	N=C(N)NCCC[C@H]1C[C@@H](OCc2ccc3ccccc3c2)CN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1	10.1021/jm060384p
	44400809	68373	0	None	-407	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	599	11	3	5	5.1	O=C(NC1CC1)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	CHEMBL191701	68373	0	None	-407	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	599	11	3	5	5.1	O=C(NC1CC1)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	2163781	97348	9	None	-4	3	Human	4.1	pKi	=	4.1	Binding	Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay	ChEMBL	289	5	3	1	4.0	c1ccc2c(CCNCc3c[nH]c4ccccc34)c[nH]c2c1	10.1016/s0960-894x(02)00088-4
	CHEMBL269653	97348	9	None	-4	3	Human	4.1	pKi	=	4.1	Binding	Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay	ChEMBL	289	5	3	1	4.0	c1ccc2c(CCNCc3c[nH]c4ccccc34)c[nH]c2c1	10.1016/s0960-894x(02)00088-4
	44401553	69796	0	None	-18	2	Human	6.1	pKi	=	6.1	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	648	14	4	5	3.7	COc1ccc(CNC(=O)[C@@H]2C[C@@H](Cc3ccccc3)CN2C(=O)[C@H](CCCN=C(N)N)NC(=O)Cc2cccc3ccccc23)cc1	10.1016/j.bmcl.2005.03.120
	CHEMBL193715	69796	0	None	-18	2	Human	6.1	pKi	=	6.1	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	648	14	4	5	3.7	COc1ccc(CNC(=O)[C@@H]2C[C@@H](Cc3ccccc3)CN2C(=O)[C@H](CCCN=C(N)N)NC(=O)Cc2cccc3ccccc23)cc1	10.1016/j.bmcl.2005.03.120
	25133903	170534	0	None	-15	3	Human	5.1	pKi	=	5.1	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	596	11	3	6	3.1	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCNc2ccccn2)C1=O	10.1021/jm800525p
	CHEMBL445009	170534	0	None	-15	3	Human	5.1	pKi	=	5.1	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	596	11	3	6	3.1	CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN(C(=O)[C@H](N)Cc2ccc(F)cc2)[C@@H](CCNc2ccccn2)C1=O	10.1021/jm800525p
	44392535	64242	0	None	-16	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards Melanocortin 3 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 3 receptor using [125I]NDP-MSH	ChEMBL	575	8	2	7	2.8	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(C2(Cn3cncn3)CCCC2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	CHEMBL180937	64242	0	None	-16	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards Melanocortin 3 receptor using [125I]NDP-MSHBinding affinity towards Melanocortin 3 receptor using [125I]NDP-MSH	ChEMBL	575	8	2	7	2.8	O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(C2(Cn3cncn3)CCCC2)CC1)C1Cc2ccccc2CN1	10.1021/jm0311285
	9960253	116923	0	None	-39	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards human Melanocortin 3 receptor (MC3R) using [125I]NDP-alpha-MSH as a radioligand in membranes of HEK 293 cellsBinding affinity towards human Melanocortin 3 receptor (MC3R) using [125I]NDP-alpha-MSH as a radioligand in membranes of HEK 293 cells	ChEMBL	595	8	3	6	2.8	CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1021/jm0304109
	CHEMBL338594	116923	0	None	-39	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards human Melanocortin 3 receptor (MC3R) using [125I]NDP-alpha-MSH as a radioligand in membranes of HEK 293 cellsBinding affinity towards human Melanocortin 3 receptor (MC3R) using [125I]NDP-alpha-MSH as a radioligand in membranes of HEK 293 cells	ChEMBL	595	8	3	6	2.8	CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)CC1	10.1021/jm0304109
	168295173	192287	0	None	-2	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	2967	62	33	39	-5.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](N)CC(C)C)CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC2=O)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5206293	192287	0	None	-2	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	2967	62	33	39	-5.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](N)CC(C)C)CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC2=O)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL89270	215876	0	None	-17	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards human Melanocortin 3 receptor (hMC3R)Binding affinity towards human Melanocortin 3 receptor (hMC3R)	ChEMBL		None	None	None		NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]cn1	10.1016/s0960-894x(03)00552-3
	CHEMBL5077144	214462	0	None	-575	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL5092761	215365	0	None	-1258	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL		None	None	None		CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N2	10.1021/acs.jmedchem.1c00095
	CHEMBL428326	213415	0	None	-17	4	Human	8.0	pKi	=	8.0	Binding	Inhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cellsInhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cells	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)CN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(N)=O	10.1021/jm0501432
	168295173	192287	0	None	-2	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	2967	62	33	39	-5.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](N)CC(C)C)CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC2=O)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5206293	192287	0	None	-2	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	2967	62	33	39	-5.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](N)CC(C)C)CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC2=O)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	44401285	135650	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	636	13	5	4	4.1	N=C(N)NCCC[C@H](NC(=O)Cc1ccc(Cl)c(Cl)c1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	CHEMBL372966	135650	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Inhibitory activity towards human Melanocortin 3 ReceptorInhibitory activity towards human Melanocortin 3 Receptor	ChEMBL	636	13	5	4	4.1	N=C(N)NCCC[C@H](NC(=O)Cc1ccc(Cl)c(Cl)c1)C(=O)N1C[C@H](Cc2ccccc2)C[C@H]1C(=O)NCc1ccccc1	10.1016/j.bmcl.2005.03.120
	44265496	97020	0	None	-13	4	Human	5.1	pKi	=	5.1	Binding	Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay	ChEMBL	453	9	3	3	3.9	NC(N)=NCCC[C@H](N)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12	10.1016/s0960-894x(02)00088-4
	CHEMBL267020	97020	0	None	-13	4	Human	5.1	pKi	=	5.1	Binding	Tested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assayTested for its binding affinity towards human recombinant Melanocortin 3 receptor by using radioligand binding assay	ChEMBL	453	9	3	3	3.9	NC(N)=NCCC[C@H](N)C(=O)N(Cc1ccc2ccccc2c1)Cc1cccc2ccccc12	10.1016/s0960-894x(02)00088-4
	10134057	88628	0	None	-5	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	375	8	2	3	3.6	C/C(=C\c1ccccc1)CN(CCCN)C(=O)C(=O)c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	CHEMBL235815	88628	0	None	-5	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	375	8	2	3	3.6	C/C(=C\c1ccccc1)CN(CCCN)C(=O)C(=O)c1c[nH]c2ccccc12	10.1016/j.bmc.2007.06.003
	44453902	95405	0	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	391	10	5	3	2.4	N=C(N)NCCC[C@H](CC1CCCCC1)NC(=O)[C@H](N)Cc1ccc(F)cc1	10.1016/j.bmcl.2007.11.109
	CHEMBL257040	95405	0	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of europium labeled NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cellsDisplacement of europium labeled NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells	ChEMBL	391	10	5	3	2.4	N=C(N)NCCC[C@H](CC1CCCCC1)NC(=O)[C@H](N)Cc1ccc(F)cc1	10.1016/j.bmcl.2007.11.109
	168274920	190239	0	None	-83	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	1319	15	14	15	0.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSCc2cccc(c2)CSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5175444	190239	0	None	-83	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	1319	15	14	15	0.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSCc2cccc(c2)CSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	44434715	167484	0	None	-3	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	593	10	2	3	7.8	COc1ccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1Br	10.1016/j.bmc.2007.06.003
	CHEMBL429983	167484	0	None	-3	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	593	10	2	3	7.8	COc1ccc(CN(C(=O)CCCc2c[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1Br	10.1016/j.bmc.2007.06.003
	44434781	89875	0	None	-15	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	485	9	2	2	7.0	NC1CCC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL237919	89875	0	None	-15	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	485	9	2	2	7.0	NC1CCC(CC2CCC(N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	44434758	88665	0	None	-100	4	Human	4.0	pKi	=	4.0	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	755	14	3	5	9.6	COc1cc(Br)c(/C=C/CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	CHEMBL236002	88665	0	None	-100	4	Human	4.0	pKi	=	4.0	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	755	14	3	5	9.6	COc1cc(Br)c(/C=C/CN(C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)C2CCC(CC3CCC(N)CC3)CC2)cc1OC	10.1016/j.bmc.2007.06.003
	25132524	176734	0	None	-5	3	Human	6.0	pKi	=	6.0	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	504	8	2	4	2.7	CC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@H](N)Cc1ccc(F)cc1	10.1021/jm800525p
	CHEMBL460349	176734	0	None	-5	3	Human	6.0	pKi	=	6.0	Binding	Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cellsDisplacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells	ChEMBL	504	8	2	4	2.7	CC[C@H]1C(=O)N([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)CCN1C(=O)[C@H](N)Cc1ccc(F)cc1	10.1021/jm800525p
	44400662	125142	0	None	-478	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	601	13	3	6	4.5	NCCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	CHEMBL364463	125142	0	None	-478	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligandBinding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand	ChEMBL	601	13	3	6	4.5	NCCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(c2ccccc2CNCCc2cccs2)CC1	10.1016/j.bmcl.2005.03.053
	44434568	89147	0	None	-213	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]NDP-MSH from MC3R receptor in HEK293 cellsDisplacement of [125I]NDP-MSH from MC3R receptor in HEK293 cells	ChEMBL	613	8	2	5	4.8	CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCNCC2=O)CC1	10.1016/j.bmc.2007.05.026
	CHEMBL236650	89147	0	None	-213	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]NDP-MSH from MC3R receptor in HEK293 cellsDisplacement of [125I]NDP-MSH from MC3R receptor in HEK293 cells	ChEMBL	613	8	2	5	4.8	CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCNCC2=O)CC1	10.1016/j.bmc.2007.05.026
	44434843	88671	0	None	-3	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	587	11	4	2	7.6	N=C(N)NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL236020	88671	0	None	-3	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	587	11	4	2	7.6	N=C(N)NC1CCC(CC2CCC(N(C/C(Cl)=C/c3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	168285313	191377	0	None	-3	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	2967	62	33	39	-5.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC2=O)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL5192562	191377	0	None	-3	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysisDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells by Topcount beta counter analysis	ChEMBL	2967	62	33	39	-5.5	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC2=O)C(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O	10.1021/acs.jmedchem.2c00786
	CHEMBL412495	212975	0	None	-79	3	Human	7.0	pKi	=	7.0	Binding	Inhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cellsInhibition of [125I]-NDP-alpha-MSH binding to melanocortin-3 receptor expressed in HEK293 cells	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]1CSSC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(=O)O)NC1=O	10.1021/jm0501432
	168272615	190363	0	None	-87	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	1319	15	14	15	0.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSCc2ccc(cc2)CSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	CHEMBL5177494	190363	0	None	-87	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assayDisplacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay	ChEMBL	1319	15	14	15	0.5	CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(C)=O)CSCc2ccc(cc2)CSC[C@@H](C(N)=O)NC1=O	10.1021/acs.jmedchem.2c00793
	44434858	167227	0	None	-9	3	Human	4.0	pKi	=	4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	529	9	4	3	5.4	N[C@H]1CC[C@H](NC(=O)N[C@H]2CC[C@H](N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	CHEMBL429269	167227	0	None	-9	3	Human	4.0	pKi	=	4	Binding	Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cellsDisplacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells	ChEMBL	529	9	4	3	5.4	N[C@H]1CC[C@H](NC(=O)N[C@H]2CC[C@H](N(Cc3ccccc3)C(=O)CCCc3c[nH]c4ccccc34)CC2)CC1	10.1016/j.bmc.2007.06.003
	11292	430	0	None	-	1	Human	6.4	pKd	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	5	2	5	1.7	NC(=N/N=C\C=C\c1cccn1c1ccccc1[N+](=O)[O-])N	None
	70669253	430	0	None	-	1	Human	6.4	pKd	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	5	2	5	1.7	NC(=N/N=C\C=C\c1cccn1c1ccccc1[N+](=O)[O-])N	None
	1321	1929	0	None	-15	3	Human	7.3	pKd	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10657491
	1328	1930	0	None	-15	4	Human	8.3	pKd	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9832440
	1333	1750	0	None	-	1	Human	8.5	pKd	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10358030
	166638272	1750	0	None	-	1	Human	8.5	pKd	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10358030
	44134812	1750	0	None	-	1	Human	8.5	pKd	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10358030
	None	216283	0	125I-NDP-MSH	-11	4	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	299	5	3	6	-0.3	CC(C)C(C(C)O)(C(=O)OCC1=CCN2C1C(CC2)O)O	None
	None	216283	0	125I-[Nle4,D-Phe7]Alpha-MSH	-11	4	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	299	5	3	6	-0.3	CC(C)C(C(C)O)(C(=O)OCC1=CCN2C1C(CC2)O)O	None
	3198	205490	76	None	-75	34	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	CHEMBL1201049	205490	76	None	-75	34	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	CHEMBL808	205490	76	None	-75	34	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	2726	916	68	None	-186	73	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	None	-186	73	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	None	-186	73	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	None	-186	73	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	None	-186	73	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	1016	3720	78	None	-56	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	2561	3720	78	None	-56	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	2733526	3720	78	None	-56	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	5384	3720	78	None	-56	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	CHEMBL83	3720	78	None	-56	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	DB00675	3720	78	None	-56	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	4189	206899	96	None	-54	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	CHEMBL1559	206899	96	None	-54	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	CHEMBL91	206899	96	None	-54	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	2247	504	81	None	-147	42	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	249	504	81	None	-147	42	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	2603	504	81	None	-147	42	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	CHEMBL296419	504	81	None	-147	42	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	DB00637	504	81	None	-147	42	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	176	397	66	None	-6	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	2157	397	66	None	-6	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	2566	397	66	None	-6	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	CHEMBL633	397	66	None	-6	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	DB01118	397	66	None	-6	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	134611880	276	0	None	-5	5	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central		None	None	None		None	None
	16132265	276	0	None	-5	5	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central		None	None	None		None	None
	3633	276	0	None	-5	5	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central		None	None	None		None	None
	4931	276	0	None	-5	5	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central		None	None	None		None	None
	CHEMBL1201610	276	0	None	-5	5	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central		None	None	None		None	None
	DB01285	276	0	None	-5	5	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central		None	None	None		None	None
	None	216284	0	125I-NDP-MSH	-7	4	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	961	29	13	12	-1.5	CSCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCC(=O)O)N	None
	None	216284	0	125I-[Nle4,D-Phe7]Alpha-MSH	-7	4	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	961	29	13	12	-1.5	CSCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCC(=O)O)N	None
	11993702	3566	18	None	-3	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central		None	None	None		None	None
	5416	3566	18	None	-3	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central		None	None	None		None	None
	9272	3566	18	None	-3	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central		None	None	None		None	None
	CHEMBL3301624	3566	18	None	-3	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central		None	None	None		None	None
	DB11700	3566	18	None	-3	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central		None	None	None		None	None
	131839615	212613	26	None	-1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central		None	None	None		CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	None
	16133835	212613	26	None	-1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central		None	None	None		CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	None
	CHEMBL407070	212613	26	None	-1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central		None	None	None		CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C	None
	10408	717	28	None	-23	4	Human	7.3	pKi	=	7.3	Binding	Inhibition of <sup>125</sup>I-NDP-αMSH binding to membranes from BHK570 cells stably expressing human MC<sub>3</sub> receptor.Inhibition of <sup>125</sup>I-NDP-αMSH binding to membranes from BHK570 cells stably expressing human MC<sub>3</sub> receptor.	Guide to Pharmacology		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	22335602
	5329	717	28	None	-23	4	Human	7.3	pKi	=	7.3	Binding	Inhibition of <sup>125</sup>I-NDP-αMSH binding to membranes from BHK570 cells stably expressing human MC<sub>3</sub> receptor.Inhibition of <sup>125</sup>I-NDP-αMSH binding to membranes from BHK570 cells stably expressing human MC<sub>3</sub> receptor.	Guide to Pharmacology		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	22335602
	9941379	717	28	None	-23	4	Human	7.3	pKi	=	7.3	Binding	Inhibition of <sup>125</sup>I-NDP-αMSH binding to membranes from BHK570 cells stably expressing human MC<sub>3</sub> receptor.Inhibition of <sup>125</sup>I-NDP-αMSH binding to membranes from BHK570 cells stably expressing human MC<sub>3</sub> receptor.	Guide to Pharmacology		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	22335602
	CHEMBL2070241	717	28	None	-23	4	Human	7.3	pKi	=	7.3	Binding	Inhibition of <sup>125</sup>I-NDP-αMSH binding to membranes from BHK570 cells stably expressing human MC<sub>3</sub> receptor.Inhibition of <sup>125</sup>I-NDP-αMSH binding to membranes from BHK570 cells stably expressing human MC<sub>3</sub> receptor.	Guide to Pharmacology		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	22335602
	DB11653	717	28	None	-23	4	Human	7.3	pKi	=	7.3	Binding	Inhibition of <sup>125</sup>I-NDP-αMSH binding to membranes from BHK570 cells stably expressing human MC<sub>3</sub> receptor.Inhibition of <sup>125</sup>I-NDP-αMSH binding to membranes from BHK570 cells stably expressing human MC<sub>3</sub> receptor.	Guide to Pharmacology		None	None	None		CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C	22335602
	134611880	276	0	None	-5	5	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7774675
	16132265	276	0	None	-5	5	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7774675
	3633	276	0	None	-5	5	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7774675
	4931	276	0	None	-5	5	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7774675
	CHEMBL1201610	276	0	None	-5	5	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7774675
	DB01285	276	0	None	-5	5	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7774675
	11993702	3566	18	None	-3	5	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	19646498
	5416	3566	18	None	-3	5	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	19646498
	9272	3566	18	None	-3	5	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	19646498
	CHEMBL3301624	3566	18	None	-3	5	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	19646498
	DB11700	3566	18	None	-3	5	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	19646498
	1325	3573	14	None	-5	7	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10657491
	1325	3573	14	None	-5	7	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12007532
	1325	3573	14	None	-5	7	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7658432
	6440621	3573	14	None	-5	7	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10657491
	6440621	3573	14	None	-5	7	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12007532
	6440621	3573	14	None	-5	7	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7658432
	9898183	3573	14	None	-5	7	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10657491
	9898183	3573	14	None	-5	7	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12007532
	9898183	3573	14	None	-5	7	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7658432
	CHEMBL3422426	3573	14	None	-5	7	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10657491
	CHEMBL3422426	3573	14	None	-5	7	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12007532
	CHEMBL3422426	3573	14	None	-5	7	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7658432
	1325	3573	14	None	-12	7	Rat	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10493100
	6440621	3573	14	None	-12	7	Rat	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10493100
	9898183	3573	14	None	-12	7	Rat	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10493100
	CHEMBL3422426	3573	14	None	-12	7	Rat	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10493100
	1320	365	0	None	3	3	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10358030
	1320	365	0	None	3	3	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10493100
	16162729	365	0	None	3	3	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10358030
	16162729	365	0	None	3	3	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10493100
	1323	2669	55	None	-72	3	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10493100
	92432	2669	55	None	-72	3	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10493100
	CHEMBL430239	2669	55	None	-72	3	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10493100
	1324	301	25	None	-2	4	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10493100
	16154396	301	25	None	-2	4	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10493100
	16197727	301	25	None	-2	4	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10493100
	44285019	301	25	None	-2	4	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10493100
	57514683	301	25	None	-2	4	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10493100
	91898441	301	25	None	-2	4	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10493100
	CHEMBL441738	301	25	None	-2	4	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10493100
	DB04931	301	25	None	-2	4	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10493100

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