Ligand source activities (1 row/activity)
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
155491018 | 174187 | None | 1 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -2 | 2 | ChEMBL | 395 | 3 | 2 | 5 | 3.1 | CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4544504 | 174187 | None | 1 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -2 | 2 | ChEMBL | 395 | 3 | 2 | 5 | 3.1 | CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 | 10.1021/acs.jmedchem.9b00742 | |||
10585 | 1079 | None | 1 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
145996522 | 1079 | None | 1 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4531005 | 1079 | None | 1 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
155491018 | 174187 | None | 1 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -2 | 2 | ChEMBL | 395 | 3 | 2 | 5 | 3.1 | CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4544504 | 174187 | None | 1 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -2 | 2 | ChEMBL | 395 | 3 | 2 | 5 | 3.1 | CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 | 10.1021/acs.jmedchem.9b00742 | |||
10585 | 1079 | None | 1 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
145996522 | 1079 | None | 1 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4531005 | 1079 | None | 1 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
155491018 | 174187 | None | 1 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -2 | 2 | ChEMBL | 395 | 3 | 2 | 5 | 3.1 | CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4544504 | 174187 | None | 1 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -2 | 2 | ChEMBL | 395 | 3 | 2 | 5 | 3.1 | CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 | 10.1021/acs.jmedchem.9b00742 | |||
155491018 | 174187 | None | 1 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -2 | 2 | ChEMBL | 395 | 3 | 2 | 5 | 3.1 | CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4544504 | 174187 | None | 1 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -2 | 2 | ChEMBL | 395 | 3 | 2 | 5 | 3.1 | CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 | 10.1021/acs.jmedchem.9b00742 | |||
44453327 | 95148 | None | 24 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 439 | 6 | 2 | 3 | 3.5 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2004.08.009 | |||
CHEMBL255408 | 95148 | None | 24 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 439 | 6 | 2 | 3 | 3.5 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2004.08.009 | |||
10585 | 1079 | None | 1 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
145996522 | 1079 | None | 1 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4531005 | 1079 | None | 1 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
10585 | 1079 | None | 1 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
145996522 | 1079 | None | 1 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4531005 | 1079 | None | 1 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
155491018 | 174187 | None | 1 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -2 | 2 | ChEMBL | 395 | 3 | 2 | 5 | 3.1 | CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4544504 | 174187 | None | 1 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -2 | 2 | ChEMBL | 395 | 3 | 2 | 5 | 3.1 | CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 | 10.1021/acs.jmedchem.9b00742 | |||
155491018 | 174187 | None | 1 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -2 | 2 | ChEMBL | 395 | 3 | 2 | 5 | 3.1 | CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4544504 | 174187 | None | 1 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -2 | 2 | ChEMBL | 395 | 3 | 2 | 5 | 3.1 | CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 | 10.1021/acs.jmedchem.9b00742 | |||
69212799 | 78005 | None | 2 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 439 | 6 | 2 | 3 | 3.5 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2004.08.009 | |||
CHEMBL2096789 | 78005 | None | 2 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 439 | 6 | 2 | 3 | 3.5 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2004.08.009 | |||
508750 | 168638 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 467 | 7 | 2 | 3 | 4.1 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NCC1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2004.08.009 | |||
CHEMBL435499 | 168638 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 467 | 7 | 2 | 3 | 4.1 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NCC1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2004.08.009 | |||
10585 | 1079 | None | 1 | Human | Functional | pEC50 | = | 7.3 | 7.3 | 1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
145996522 | 1079 | None | 1 | Human | Functional | pEC50 | = | 7.3 | 7.3 | 1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4531005 | 1079 | None | 1 | Human | Functional | pEC50 | = | 7.3 | 7.3 | 1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
10585 | 1079 | None | 1 | Human | Functional | pEC50 | = | 7.3 | 7.3 | 1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
145996522 | 1079 | None | 1 | Human | Functional | pEC50 | = | 7.3 | 7.3 | 1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4531005 | 1079 | None | 1 | Human | Functional | pEC50 | = | 7.3 | 7.3 | 1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
44395055 | 64525 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 453 | 6 | 2 | 3 | 3.9 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CCCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2004.08.009 | |||
CHEMBL181432 | 64525 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 453 | 6 | 2 | 3 | 3.9 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CCCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2004.08.009 | |||
73351183 | 93287 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 453 | 7 | 2 | 3 | 3.9 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC[C@@H]1CCCN1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2004.08.009 | |||
CHEMBL2448120 | 93287 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 453 | 7 | 2 | 3 | 3.9 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC[C@@H]1CCCN1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2004.08.009 | |||
70697571 | 78004 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 453 | 7 | 2 | 3 | 3.9 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC[C@H]1CCCN1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2004.08.009 | |||
CHEMBL2096788 | 78004 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 453 | 7 | 2 | 3 | 3.9 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC[C@H]1CCCN1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2004.08.009 | |||
11735999 | 189459 | None | 0 | Human | Functional | pED50 | = | 10.4 | 10.4 | - | 1 | ChEMBL | 212 | 1 | 2 | 2 | 0.8 | CC(C)(C)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
CHEMBL512607 | 189459 | None | 0 | Human | Functional | pED50 | = | 10.4 | 10.4 | - | 1 | ChEMBL | 212 | 1 | 2 | 2 | 0.8 | CC(C)(C)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
11322108 | 178672 | None | 0 | Human | Functional | pED50 | = | 10.2 | 10.2 | - | 1 | ChEMBL | 226 | 3 | 2 | 2 | 1.2 | CCC(C)(C)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
CHEMBL467070 | 178672 | None | 0 | Human | Functional | pED50 | = | 10.2 | 10.2 | - | 1 | ChEMBL | 226 | 3 | 2 | 2 | 1.2 | CCC(C)(C)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
11254190 | 189461 | None | 0 | Human | Functional | pED50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 268 | 5 | 2 | 2 | 2.2 | CC(C)CCC(C)(C)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
CHEMBL512615 | 189461 | None | 0 | Human | Functional | pED50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 268 | 5 | 2 | 2 | 2.2 | CC(C)CCC(C)(C)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
11651747 | 173873 | None | 0 | Human | Functional | pED50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 252 | 2 | 2 | 2 | 1.7 | CC1(C(=O)N[C@H]2CCCCNC2=O)CCCCC1 | 10.1021/jm900133w | |||
CHEMBL453720 | 173873 | None | 0 | Human | Functional | pED50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 252 | 2 | 2 | 2 | 1.7 | CC1(C(=O)N[C@H]2CCCCNC2=O)CCCCC1 | 10.1021/jm900133w | |||
11659300 | 178869 | None | 0 | Human | Functional | pED50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 290 | 2 | 2 | 2 | 2.0 | O=C1NCCCC[C@@H]1NC(=O)C12CC3CC(CC(C3)C1)C2 | 10.1021/jm900133w | |||
CHEMBL468733 | 178869 | None | 0 | Human | Functional | pED50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 290 | 2 | 2 | 2 | 2.0 | O=C1NCCCC[C@@H]1NC(=O)C12CC3CC(CC(C3)C1)C2 | 10.1021/jm900133w | |||
11151928 | 189596 | None | 0 | Human | Functional | pED50 | = | 10.1 | 10.1 | 1 | 4 | ChEMBL | 338 | 11 | 2 | 2 | 4.3 | CCCCCCCCCCC(C)(C)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
CHEMBL513863 | 189596 | None | 0 | Human | Functional | pED50 | = | 10.1 | 10.1 | 1 | 4 | ChEMBL | 338 | 11 | 2 | 2 | 4.3 | CCCCCCCCCCC(C)(C)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
11173161 | 188915 | None | 0 | Human | Functional | pED50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 266 | 4 | 2 | 2 | 2.2 | CC(C)=CCC(C)(C)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
CHEMBL506023 | 188915 | None | 0 | Human | Functional | pED50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 266 | 4 | 2 | 2 | 2.2 | CC(C)=CCC(C)(C)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
44157844 | 189398 | None | 0 | Human | Functional | pED50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 290 | 2 | 2 | 2 | 2.0 | O=C1NCCCC[C@H]1NC(=O)C12CC3CC(CC(C3)C1)C2 | 10.1021/jm900133w | |||
CHEMBL512094 | 189398 | None | 0 | Human | Functional | pED50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 290 | 2 | 2 | 2 | 2.0 | O=C1NCCCC[C@H]1NC(=O)C12CC3CC(CC(C3)C1)C2 | 10.1021/jm900133w | |||
11218678 | 170456 | None | 0 | Human | Functional | pED50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 240 | 4 | 2 | 2 | 1.6 | CCCC(C)(C)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
CHEMBL444736 | 170456 | None | 0 | Human | Functional | pED50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 240 | 4 | 2 | 2 | 1.6 | CCCC(C)(C)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
11543222 | 193616 | None | 2 | Human | Functional | pED50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 238 | 2 | 2 | 2 | 1.4 | O=C(N[C@H]1CCCCNC1=O)C1CCCCC1 | 10.1021/jm900133w | |||
CHEMBL526704 | 193616 | None | 2 | Human | Functional | pED50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 238 | 2 | 2 | 2 | 1.4 | O=C(N[C@H]1CCCCNC1=O)C1CCCCC1 | 10.1021/jm900133w | |||
11536008 | 178699 | None | 0 | Human | Functional | pED50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 236 | 2 | 2 | 2 | 1.3 | O=C(N[C@H]1CCCCNC1=O)C1=CCCCC1 | 10.1021/jm900133w | |||
CHEMBL467276 | 178699 | None | 0 | Human | Functional | pED50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 236 | 2 | 2 | 2 | 1.3 | O=C(N[C@H]1CCCCNC1=O)C1=CCCCC1 | 10.1021/jm900133w | |||
11551248 | 178765 | None | 0 | Human | Functional | pED50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 304 | 3 | 2 | 2 | 2.4 | O=C(CC12CC3CC(CC(C3)C1)C2)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
CHEMBL467685 | 178765 | None | 0 | Human | Functional | pED50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 304 | 3 | 2 | 2 | 2.4 | O=C(CC12CC3CC(CC(C3)C1)C2)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
11390777 | 172719 | None | 0 | Human | Functional | pED50 | = | 9 | 9.0 | - | 0 | ChEMBL | 238 | 4 | 2 | 2 | 1.4 | C=CCC(C)(C)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
CHEMBL449215 | 172719 | None | 0 | Human | Functional | pED50 | = | 9 | 9.0 | - | 0 | ChEMBL | 238 | 4 | 2 | 2 | 1.4 | C=CCC(C)(C)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
11198073 | 178584 | None | 0 | Human | Functional | pED50 | = | 8 | 8.0 | - | 1 | ChEMBL | 322 | 10 | 2 | 2 | 3.9 | CCCCCCCCC/C=C(\C)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
CHEMBL466434 | 178584 | None | 0 | Human | Functional | pED50 | = | 8 | 8.0 | - | 1 | ChEMBL | 322 | 10 | 2 | 2 | 3.9 | CCCCCCCCC/C=C(\C)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
11370332 | 63316 | None | 0 | Human | Functional | pED50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 310 | 11 | 2 | 2 | 3.7 | CCCCCCCCCCCC(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
CHEMBL179312 | 63316 | None | 0 | Human | Functional | pED50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 310 | 11 | 2 | 2 | 3.7 | CCCCCCCCCCCC(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
44157843 | 178582 | None | 0 | Human | Functional | pED50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 324 | 11 | 2 | 2 | 3.9 | CCCCCCCCCCC(C)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
CHEMBL466432 | 178582 | None | 0 | Human | Functional | pED50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 324 | 11 | 2 | 2 | 3.9 | CCCCCCCCCCC(C)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
44157843 | 178582 | None | 0 | Human | Functional | pED50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 324 | 11 | 2 | 2 | 3.9 | CCCCCCCCCCC(C)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
CHEMBL466432 | 178582 | None | 0 | Human | Functional | pED50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 324 | 11 | 2 | 2 | 3.9 | CCCCCCCCCCC(C)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
11151929 | 178868 | None | 0 | Human | Functional | pED50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 338 | 11 | 2 | 2 | 4.3 | CCCCCCCCCC(C)(C)CC(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
CHEMBL468732 | 178868 | None | 0 | Human | Functional | pED50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 338 | 11 | 2 | 2 | 4.3 | CCCCCCCCCC(C)(C)CC(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
11359715 | 178867 | None | 0 | Human | Functional | pED50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 338 | 11 | 2 | 2 | 4.3 | CCCCCCCCCCC(C)(C)C(=O)N[C@@H]1CCCCNC1=O | 10.1021/jm900133w | |||
CHEMBL468720 | 178867 | None | 0 | Human | Functional | pED50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 338 | 11 | 2 | 2 | 4.3 | CCCCCCCCCCC(C)(C)C(=O)N[C@@H]1CCCCNC1=O | 10.1021/jm900133w | |||
11544064 | 178583 | None | 0 | Human | Functional | pED50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 308 | 6 | 2 | 2 | 3.2 | CCCCCC1CCC(C(=O)N[C@H]2CCCCNC2=O)CC1 | 10.1021/jm900133w | |||
CHEMBL466433 | 178583 | None | 0 | Human | Functional | pED50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 308 | 6 | 2 | 2 | 3.2 | CCCCCC1CCC(C(=O)N[C@H]2CCCCNC2=O)CC1 | 10.1021/jm900133w | |||
11609693 | 189321 | None | 0 | Human | Functional | pED50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 334 | 6 | 2 | 2 | 3.7 | CCCCCC12CCC(C(=O)N[C@H]3CCCCNC3=O)(CC1)CC2 | 10.1021/jm900133w | |||
CHEMBL511426 | 189321 | None | 0 | Human | Functional | pED50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 334 | 6 | 2 | 2 | 3.7 | CCCCCC12CCC(C(=O)N[C@H]3CCCCNC3=O)(CC1)CC2 | 10.1021/jm900133w | |||
11437477 | 188731 | None | 0 | Human | Functional | pED50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 280 | 4 | 2 | 2 | 1.3 | CC(CCl)(CCl)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
CHEMBL502976 | 188731 | None | 0 | Human | Functional | pED50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 280 | 4 | 2 | 2 | 1.3 | CC(CCl)(CCl)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
44593562 | 187601 | None | 0 | Human | Functional | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 494 | 6 | 2 | 3 | 5.6 | CC1COCCC1N[C@@H]1CC[C@@](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(C(C)C)C1 | 10.1016/j.bmcl.2008.12.050 | |||
CHEMBL494191 | 187601 | None | 0 | Human | Functional | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 494 | 6 | 2 | 3 | 5.6 | CC1COCCC1N[C@@H]1CC[C@@](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(C(C)C)C1 | 10.1016/j.bmcl.2008.12.050 | |||
86642531 | 138390 | None | 0 | Human | Functional | pIC50 | = | 9.9 | 9.9 | 10 | 2 | ChEMBL | 482 | 2 | 2 | 6 | 2.6 | CC(C)(C)N1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3nc(C(F)(F)F)c(Cl)s3)CC2)C1 | 10.1039/C5MD00362H | |||
CHEMBL3770912 | 138390 | None | 0 | Human | Functional | pIC50 | = | 9.9 | 9.9 | 10 | 2 | ChEMBL | 482 | 2 | 2 | 6 | 2.6 | CC(C)(C)N1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3nc(C(F)(F)F)c(Cl)s3)CC2)C1 | 10.1039/C5MD00362H | |||
44425645 | 86116 | None | 0 | Human | Functional | pIC50 | = | 9.8 | 9.8 | 7 | 2 | ChEMBL | 528 | 5 | 1 | 2 | 7.0 | CC(C)[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2007.04.053 | |||
CHEMBL230933 | 86116 | None | 0 | Human | Functional | pIC50 | = | 9.8 | 9.8 | 7 | 2 | ChEMBL | 528 | 5 | 1 | 2 | 7.0 | CC(C)[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2007.04.053 | |||
10240064 | 188535 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 599 | 10 | 2 | 6 | 4.6 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL502247 | 188535 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 599 | 10 | 2 | 6 | 4.6 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
44593562 | 187601 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 494 | 6 | 2 | 3 | 5.6 | CC1COCCC1N[C@@H]1CC[C@@](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(C(C)C)C1 | 10.1016/j.bmcl.2008.12.050 | |||
CHEMBL494191 | 187601 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 494 | 6 | 2 | 3 | 5.6 | CC1COCCC1N[C@@H]1CC[C@@](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(C(C)C)C1 | 10.1016/j.bmcl.2008.12.050 | |||
44425652 | 168871 | None | 0 | Human | Functional | pIC50 | = | 9.6 | 9.6 | 12 | 2 | ChEMBL | 526 | 5 | 1 | 2 | 6.7 | C[C@H]1CN([C@@H]2CC[C@@](C(=O)NCc3cc(F)cc(C(F)(F)F)c3)(C3CC3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2007.04.053 | |||
CHEMBL437359 | 168871 | None | 0 | Human | Functional | pIC50 | = | 9.6 | 9.6 | 12 | 2 | ChEMBL | 526 | 5 | 1 | 2 | 6.7 | C[C@H]1CN([C@@H]2CC[C@@](C(=O)NCc3cc(F)cc(C(F)(F)F)c3)(C3CC3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2007.04.053 | |||
10289827 | 188082 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 571 | 9 | 2 | 6 | 3.8 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C)CC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL497202 | 188082 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 571 | 9 | 2 | 6 | 3.8 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C)CC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
44593563 | 193219 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 508 | 7 | 2 | 3 | 5.9 | CCC1COCCC1N[C@@H]1CC[C@@](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(C(C)C)C1 | 10.1016/j.bmcl.2008.12.050 | |||
CHEMBL522688 | 193219 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 508 | 7 | 2 | 3 | 5.9 | CCC1COCCC1N[C@@H]1CC[C@@](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(C(C)C)C1 | 10.1016/j.bmcl.2008.12.050 | |||
44425647 | 86135 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | 5 | 2 | ChEMBL | 542 | 6 | 1 | 2 | 7.4 | CC(C)C[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2007.04.053 | |||
CHEMBL231039 | 86135 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | 5 | 2 | ChEMBL | 542 | 6 | 1 | 2 | 7.4 | CC(C)C[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2007.04.053 | |||
44425292 | 86002 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 627 | 9 | 3 | 5 | 6.6 | CNC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL230281 | 86002 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 627 | 9 | 3 | 5 | 6.6 | CNC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
44425292 | 86002 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 627 | 9 | 3 | 5 | 6.6 | CNC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL230281 | 86002 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 627 | 9 | 3 | 5 | 6.6 | CNC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
10240064 | 188535 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 599 | 10 | 2 | 6 | 4.6 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL502247 | 188535 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 599 | 10 | 2 | 6 | 4.6 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
46865775 | 8116 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 579 | 8 | 1 | 5 | 4.4 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2010.03.035 | |||
CHEMBL1091605 | 8116 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 579 | 8 | 1 | 5 | 4.4 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2010.03.035 | |||
24801689 | 97847 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 651 | 9 | 5 | 6 | 3.5 | NS(=O)(=O)c1ccc(C(=O)N[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)C2CCCCC2)cc1 | 10.1021/jm701488f | |||
CHEMBL271828 | 97847 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 651 | 9 | 5 | 6 | 3.5 | NS(=O)(=O)c1ccc(C(=O)N[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)C2CCCCC2)cc1 | 10.1021/jm701488f | |||
44425255 | 168987 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 650 | 8 | 2 | 5 | 7.2 | CC(=O)Nc1nc(C(CCN2CCC3(C=Cc4ccccc43)[C@@H](C)C2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
CHEMBL438304 | 168987 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 650 | 8 | 2 | 5 | 7.2 | CC(=O)Nc1nc(C(CCN2CCC3(C=Cc4ccccc43)[C@@H](C)C2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
44425652 | 168871 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 12 | 2 | ChEMBL | 526 | 5 | 1 | 2 | 6.7 | C[C@H]1CN([C@@H]2CC[C@@](C(=O)NCc3cc(F)cc(C(F)(F)F)c3)(C3CC3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2007.04.053 | |||
CHEMBL437359 | 168871 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 12 | 2 | ChEMBL | 526 | 5 | 1 | 2 | 6.7 | C[C@H]1CN([C@@H]2CC[C@@](C(=O)NCc3cc(F)cc(C(F)(F)F)c3)(C3CC3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2007.04.053 | |||
59370257 | 138251 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 428 | 2 | 2 | 6 | 1.9 | Cc1nc(NC(=O)N2CCN(C(=O)[C@H]3CN(C(C)(C)C)CCN3)CC2)sc1Cl | 10.1039/C5MD00362H | |||
CHEMBL3769444 | 138251 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 428 | 2 | 2 | 6 | 1.9 | Cc1nc(NC(=O)N2CCN(C(=O)[C@H]3CN(C(C)(C)C)CCN3)CC2)sc1Cl | 10.1039/C5MD00362H | |||
10129192 | 188566 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 599 | 11 | 2 | 6 | 4.6 | CCN(CC)[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)[C@H](CS(=O)(=O)c2ccc(SC)cc2)C1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL502793 | 188566 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 599 | 11 | 2 | 6 | 4.6 | CCN(CC)[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)[C@H](CS(=O)(=O)c2ccc(SC)cc2)C1 | 10.1016/j.bmcl.2009.05.041 | |||
11598 | 673 | None | 13 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 812 | 2 | ChEMBL | 506 | 6 | 2 | 6 | 3.4 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1021/acsmedchemlett.1c00373 | |||
23725177 | 673 | None | 13 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 812 | 2 | ChEMBL | 506 | 6 | 2 | 6 | 3.4 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1021/acsmedchemlett.1c00373 | |||
CHEMBL4442783 | 673 | None | 13 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 812 | 2 | ChEMBL | 506 | 6 | 2 | 6 | 3.4 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1021/acsmedchemlett.1c00373 | |||
44425254 | 142347 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 636 | 8 | 2 | 5 | 7.0 | CC(=O)Nc1nc(C(CCN2CCC3(C=Cc4ccccc43)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
CHEMBL388487 | 142347 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 636 | 8 | 2 | 5 | 7.0 | CC(=O)Nc1nc(C(CCN2CCC3(C=Cc4ccccc43)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
16216716 | 153618 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 612 | 9 | 2 | 5 | 6.8 | CC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
CHEMBL397996 | 153618 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 612 | 9 | 2 | 5 | 6.8 | CC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
44425645 | 86116 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 7 | 2 | ChEMBL | 528 | 5 | 1 | 2 | 7.0 | CC(C)[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2007.04.053 | |||
CHEMBL230933 | 86116 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 7 | 2 | ChEMBL | 528 | 5 | 1 | 2 | 7.0 | CC(C)[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2007.04.053 | |||
11597 | 674 | None | 6 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 11 | 2 | ChEMBL | 506 | 5 | 3 | 6 | 3.5 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C | 10.1021/acsmedchemlett.1c00373 | |||
23725180 | 674 | None | 6 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 11 | 2 | ChEMBL | 506 | 5 | 3 | 6 | 3.5 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C | 10.1021/acsmedchemlett.1c00373 | |||
CHEMBL4781426 | 674 | None | 6 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 11 | 2 | ChEMBL | 506 | 5 | 3 | 6 | 3.5 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C | 10.1021/acsmedchemlett.1c00373 | |||
51039119 | 176321 | None | 34 | Human | Functional | pIC50 | = | 9.1 | 9.1 | -1 | 3 | ChEMBL | 484 | 5 | 3 | 8 | 2.2 | CC(=O)N[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1N1CC[C@H](Nc2ncnc3cc(C(C)(C)C)nn23)C1=O | 10.1021/acsmedchemlett.1c00373 | |||
CHEMBL4594419 | 176321 | None | 34 | Human | Functional | pIC50 | = | 9.1 | 9.1 | -1 | 3 | ChEMBL | 484 | 5 | 3 | 8 | 2.2 | CC(=O)N[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1N1CC[C@H](Nc2ncnc3cc(C(C)(C)C)nn23)C1=O | 10.1021/acsmedchemlett.1c00373 | |||
44593564 | 187338 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 498 | 6 | 2 | 3 | 5.3 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](NC2CCOCC2F)C1 | 10.1016/j.bmcl.2008.12.050 | |||
CHEMBL492564 | 187338 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 498 | 6 | 2 | 3 | 5.3 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](NC2CCOCC2F)C1 | 10.1016/j.bmcl.2008.12.050 | |||
25022597 | 95392 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 448 | 6 | 3 | 4 | 3.0 | Cc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)c(C)c1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL256629 | 95392 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 448 | 6 | 3 | 4 | 3.0 | Cc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)c(C)c1 | 10.1016/j.bmcl.2008.02.015 | |||
44453440 | 97741 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 448 | 7 | 3 | 4 | 3.0 | CCc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL271288 | 97741 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 448 | 7 | 3 | 4 | 3.0 | CCc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
183790 | 3742 | None | 8 | Human | Functional | pIC50 | = | 9.0 | 9.0 | -1 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1016/j.bmc.2015.02.019 | |||
783 | 3742 | None | 8 | Human | Functional | pIC50 | = | 9.0 | 9.0 | -1 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1016/j.bmc.2015.02.019 | |||
CHEMBL1178786 | 3742 | None | 8 | Human | Functional | pIC50 | = | 9.0 | 9.0 | -1 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1016/j.bmc.2015.02.019 | |||
183790 | 3742 | None | 8 | Human | Functional | pIC50 | = | 9.0 | 9.0 | -1 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1016/j.ejmech.2017.04.046 | |||
783 | 3742 | None | 8 | Human | Functional | pIC50 | = | 9.0 | 9.0 | -1 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1016/j.ejmech.2017.04.046 | |||
CHEMBL1178786 | 3742 | None | 8 | Human | Functional | pIC50 | = | 9.0 | 9.0 | -1 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1016/j.ejmech.2017.04.046 | |||
24801690 | 98094 | None | 20 | Human | Functional | pIC50 | = | 9 | 9.0 | 95 | 5 | ChEMBL | 593 | 9 | 5 | 5 | 4.5 | CSc1ccc(C(=O)N[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL273083 | 98094 | None | 20 | Human | Functional | pIC50 | = | 9 | 9.0 | 95 | 5 | ChEMBL | 593 | 9 | 5 | 5 | 4.5 | CSc1ccc(C(=O)N[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
57402219 | 71032 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | 52 | 2 | ChEMBL | 503 | 6 | 3 | 4 | 3.8 | Cc1ccc([C@]2(O)CC[C@H](N3CC[C@@H](NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cc1 | 10.1021/ml200030q | |||
CHEMBL1951766 | 71032 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | 52 | 2 | ChEMBL | 503 | 6 | 3 | 4 | 3.8 | Cc1ccc([C@]2(O)CC[C@H](N3CC[C@@H](NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cc1 | 10.1021/ml200030q | |||
24801690 | 98094 | None | 20 | Human | Functional | pIC50 | = | 9 | 9.0 | 95 | 5 | ChEMBL | 593 | 9 | 5 | 5 | 4.5 | CSc1ccc(C(=O)N[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)cc1 | 10.1021/jm701488f | |||
CHEMBL273083 | 98094 | None | 20 | Human | Functional | pIC50 | = | 9 | 9.0 | 95 | 5 | ChEMBL | 593 | 9 | 5 | 5 | 4.5 | CSc1ccc(C(=O)N[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)cc1 | 10.1021/jm701488f | |||
44593564 | 187338 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 498 | 6 | 2 | 3 | 5.3 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](NC2CCOCC2F)C1 | 10.1016/j.bmcl.2008.12.050 | |||
CHEMBL492564 | 187338 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 498 | 6 | 2 | 3 | 5.3 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](NC2CCOCC2F)C1 | 10.1016/j.bmcl.2008.12.050 | |||
44573649 | 187341 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 548 | 6 | 2 | 3 | 6.1 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](NC2CCOCC2C(F)(F)F)C1 | 10.1016/j.bmcl.2008.12.050 | |||
CHEMBL492569 | 187341 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 548 | 6 | 2 | 3 | 6.1 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](NC2CCOCC2C(F)(F)F)C1 | 10.1016/j.bmcl.2008.12.050 | |||
44593562 | 187601 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 494 | 6 | 2 | 3 | 5.6 | CC1COCCC1N[C@@H]1CC[C@@](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(C(C)C)C1 | 10.1016/j.bmcl.2008.12.050 | |||
CHEMBL494191 | 187601 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 494 | 6 | 2 | 3 | 5.6 | CC1COCCC1N[C@@H]1CC[C@@](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(C(C)C)C1 | 10.1016/j.bmcl.2008.12.050 | |||
10175425 | 193642 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 614 | 10 | 3 | 7 | 4.2 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL526752 | 193642 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 614 | 10 | 3 | 7 | 4.2 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
127025088 | 138350 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 420 | 3 | 2 | 6 | 1.8 | CC(C)(C)N1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3nc(C4CC4)cs3)CC2)C1 | 10.1039/C5MD00362H | |||
CHEMBL3770530 | 138350 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 420 | 3 | 2 | 6 | 1.8 | CC(C)(C)N1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3nc(C4CC4)cs3)CC2)C1 | 10.1039/C5MD00362H | |||
127025086 | 138270 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 442 | 4 | 2 | 6 | 2.3 | CC(C)c1nc(NC(=O)N2CCN(C(=O)[C@H]3CN(C(C)C)CCN3)CC2)sc1Cl | 10.1039/C5MD00362H | |||
CHEMBL3769610 | 138270 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 442 | 4 | 2 | 6 | 2.3 | CC(C)c1nc(NC(=O)N2CCN(C(=O)[C@H]3CN(C(C)C)CCN3)CC2)sc1Cl | 10.1039/C5MD00362H | |||
46865774 | 8115 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 553 | 9 | 2 | 5 | 3.9 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2010.03.035 | |||
CHEMBL1091604 | 8115 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 553 | 9 | 2 | 5 | 3.9 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2010.03.035 | |||
86642531 | 138390 | None | 0 | Rat | Functional | pIC50 | = | 8.9 | 8.9 | -10 | 2 | ChEMBL | 482 | 2 | 2 | 6 | 2.6 | CC(C)(C)N1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3nc(C(F)(F)F)c(Cl)s3)CC2)C1 | 10.1039/C5MD00362H | |||
CHEMBL3770912 | 138390 | None | 0 | Rat | Functional | pIC50 | = | 8.9 | 8.9 | -10 | 2 | ChEMBL | 482 | 2 | 2 | 6 | 2.6 | CC(C)(C)N1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3nc(C(F)(F)F)c(Cl)s3)CC2)C1 | 10.1039/C5MD00362H | |||
10007642 | 19116 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | 2 | 2 | ChEMBL | 547 | 8 | 3 | 5 | 3.8 | CCO[C@H]1CN([C@H]2CC[C@@](O)(c3ccc(C)cc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.10.020 | |||
CHEMBL1289203 | 19116 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | 2 | 2 | ChEMBL | 547 | 8 | 3 | 5 | 3.8 | CCO[C@H]1CN([C@H]2CC[C@@](O)(c3ccc(C)cc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.10.020 | |||
10218403 | 188016 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 557 | 9 | 3 | 6 | 3.5 | CN[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)[C@H](CS(=O)(=O)c2ccc(SC)cc2)C1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL496630 | 188016 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 557 | 9 | 3 | 6 | 3.5 | CN[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)[C@H](CS(=O)(=O)c2ccc(SC)cc2)C1 | 10.1016/j.bmcl.2009.05.041 | |||
46886055 | 8046 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 593 | 9 | 1 | 5 | 4.8 | CCN(C(C)C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2010.03.035 | |||
CHEMBL1090893 | 8046 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 593 | 9 | 1 | 5 | 4.8 | CCN(C(C)C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2010.03.035 | |||
127025093 | 138301 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 428 | 4 | 2 | 6 | 1.7 | CCc1nc(NC(=O)N2CCN(C(=O)[C@H]3CN(C(C)C)CCN3)CC2)sc1Cl | 10.1039/C5MD00362H | |||
CHEMBL3769984 | 138301 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 428 | 4 | 2 | 6 | 1.7 | CCc1nc(NC(=O)N2CCN(C(=O)[C@H]3CN(C(C)C)CCN3)CC2)sc1Cl | 10.1039/C5MD00362H | |||
46830335 | 8217 | None | 8 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 565 | 8 | 2 | 5 | 2.7 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCN2CCN(C(=O)c3ccccc3Cl)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1092238 | 8217 | None | 8 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 565 | 8 | 2 | 5 | 2.7 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCN2CCN(C(=O)c3ccccc3Cl)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
11365166 | 74570 | None | 1 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 573 | 7 | 3 | 7 | 4.0 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4nccs4)cn3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
CHEMBL2029423 | 74570 | None | 1 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 573 | 7 | 3 | 7 | 4.0 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4nccs4)cn3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
52941377 | 19336 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 7 | 2 | ChEMBL | 531 | 9 | 2 | 4 | 4.8 | CCCO[C@H]1CN([C@H]2CC[C@@H](c3ccccc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.10.020 | |||
CHEMBL1290637 | 19336 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 7 | 2 | ChEMBL | 531 | 9 | 2 | 4 | 4.8 | CCCO[C@H]1CN([C@H]2CC[C@@H](c3ccccc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.10.020 | |||
16216716 | 153618 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 612 | 9 | 2 | 5 | 6.8 | CC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL397996 | 153618 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 612 | 9 | 2 | 5 | 6.8 | CC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
44425292 | 86002 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 627 | 9 | 3 | 5 | 6.6 | CNC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
CHEMBL230281 | 86002 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 627 | 9 | 3 | 5 | 6.6 | CNC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
16216716 | 153618 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 612 | 9 | 2 | 5 | 6.8 | CC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL397996 | 153618 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 612 | 9 | 2 | 5 | 6.8 | CC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
11353855 | 74575 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 595 | 6 | 2 | 8 | 4.2 | O=C(C1CCN(c2cc(C(F)(F)F)ccn2)CC1)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncccn4)cn3)CC2)C1 | 10.1021/ml200199c | |||
CHEMBL2029568 | 74575 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 595 | 6 | 2 | 8 | 4.2 | O=C(C1CCN(c2cc(C(F)(F)F)ccn2)CC1)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncccn4)cn3)CC2)C1 | 10.1021/ml200199c | |||
44425652 | 168871 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 12 | 2 | ChEMBL | 526 | 5 | 1 | 2 | 6.7 | C[C@H]1CN([C@@H]2CC[C@@](C(=O)NCc3cc(F)cc(C(F)(F)F)c3)(C3CC3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL437359 | 168871 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 12 | 2 | ChEMBL | 526 | 5 | 1 | 2 | 6.7 | C[C@H]1CN([C@@H]2CC[C@@](C(=O)NCc3cc(F)cc(C(F)(F)F)c3)(C3CC3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
44425652 | 168871 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 12 | 2 | ChEMBL | 526 | 5 | 1 | 2 | 6.7 | C[C@H]1CN([C@@H]2CC[C@@](C(=O)NCc3cc(F)cc(C(F)(F)F)c3)(C3CC3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL437359 | 168871 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 12 | 2 | ChEMBL | 526 | 5 | 1 | 2 | 6.7 | C[C@H]1CN([C@@H]2CC[C@@](C(=O)NCc3cc(F)cc(C(F)(F)F)c3)(C3CC3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
57335017 | 70362 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | 1380 | 2 | ChEMBL | 595 | 8 | 4 | 6 | 2.8 | N[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N2CCC2)C[C@@H]1CS(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2011.12.057 | |||
CHEMBL1944776 | 70362 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | 1380 | 2 | ChEMBL | 595 | 8 | 4 | 6 | 2.8 | N[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N2CCC2)C[C@@H]1CS(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2011.12.057 | |||
70691785 | 73753 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 606 | 12 | 6 | 6 | 2.9 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)N1CCNCC1 | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018391 | 73753 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 606 | 12 | 6 | 6 | 2.9 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)N1CCNCC1 | 10.1016/j.bmcl.2012.03.007 | |||
46830336 | 7852 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 567 | 8 | 2 | 5 | 2.4 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCN2CCN(C(=O)c3cc(F)ccc3F)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1089793 | 7852 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 567 | 8 | 2 | 5 | 2.4 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCN2CCN(C(=O)c3cc(F)ccc3F)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
54754967 | 77859 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 518 | 7 | 4 | 7 | 3.0 | COc1ccc([C@]2(O)CC[C@H](N3CC(NC(=O)CNc4n[nH]c5ccc(C(F)(F)F)cc45)C3)CC2)cn1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL2092884 | 77859 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 518 | 7 | 4 | 7 | 3.0 | COc1ccc([C@]2(O)CC[C@H](N3CC(NC(=O)CNc4n[nH]c5ccc(C(F)(F)F)cc45)C3)CC2)cn1 | 10.1016/j.bmcl.2011.08.074 | |||
10239991 | 188554 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 585 | 10 | 3 | 6 | 4.3 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](NC(C)C)CC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL502516 | 188554 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 585 | 10 | 3 | 6 | 4.3 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](NC(C)C)CC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
57391766 | 71041 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 491 | 6 | 3 | 6 | 2.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN([C@H]2CC[C@@](O)(c3cnccn3)CC2)C1 | 10.1021/ml200030q | |||
CHEMBL1951776 | 71041 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 491 | 6 | 3 | 6 | 2.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN([C@H]2CC[C@@](O)(c3cnccn3)CC2)C1 | 10.1021/ml200030q | |||
10187492 | 147878 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 549 | 11 | 5 | 5 | 3.7 | CCNc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@@H](CNCc1ccc(C)cc1C)C(=O)NC(C)(C)C | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL393267 | 147878 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 549 | 11 | 5 | 5 | 3.7 | CCNc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@@H](CNCc1ccc(C)cc1C)C(=O)NC(C)(C)C | 10.1016/j.bmcl.2007.07.028 | |||
25256791 | 187797 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 494 | 6 | 2 | 3 | 5.6 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N[C@H]2CCOC[C@H]2C)C1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL495202 | 187797 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 494 | 6 | 2 | 3 | 5.6 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N[C@H]2CCOC[C@H]2C)C1 | 10.1016/j.bmcl.2010.02.072 | |||
11502371 | 153217 | None | 3 | Human | Functional | pIC50 | = | 7 | 7.0 | 22 | 2 | ChEMBL | 407 | 5 | 1 | 2 | 5.0 | C[N+](C)(Cc1ccc(NC(=O)c2ccc(Cl)c(Cl)c2)cc1)C1CCOCC1 | 10.1016/j.bmcl.2007.01.115 | |||
CHEMBL397647 | 153217 | None | 3 | Human | Functional | pIC50 | = | 7 | 7.0 | 22 | 2 | ChEMBL | 407 | 5 | 1 | 2 | 5.0 | C[N+](C)(Cc1ccc(NC(=O)c2ccc(Cl)c(Cl)c2)cc1)C1CCOCC1 | 10.1016/j.bmcl.2007.01.115 | |||
11502371 | 153217 | None | 3 | Human | Functional | pIC50 | = | 7 | 7.0 | 22 | 2 | ChEMBL | 407 | 5 | 1 | 2 | 5.0 | C[N+](C)(Cc1ccc(NC(=O)c2ccc(Cl)c(Cl)c2)cc1)C1CCOCC1 | 10.1016/j.bmcl.2007.01.115 | |||
CHEMBL397647 | 153217 | None | 3 | Human | Functional | pIC50 | = | 7 | 7.0 | 22 | 2 | ChEMBL | 407 | 5 | 1 | 2 | 5.0 | C[N+](C)(Cc1ccc(NC(=O)c2ccc(Cl)c(Cl)c2)cc1)C1CCOCC1 | 10.1016/j.bmcl.2007.01.115 | |||
10154434 | 58806 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 342 | 4 | 2 | 5 | 3.2 | CC(C)Oc1cccc(NC(=O)NC(=O)c2ccc3c(c2)OCO3)c1 | 10.1021/jm1012903 | |||
CHEMBL1687955 | 58806 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 342 | 4 | 2 | 5 | 3.2 | CC(C)Oc1cccc(NC(=O)NC(=O)c2ccc3c(c2)OCO3)c1 | 10.1021/jm1012903 | |||
44413167 | 79750 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 447 | 8 | 2 | 3 | 4.2 | CN(C)CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL211560 | 79750 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 447 | 8 | 2 | 3 | 4.2 | CN(C)CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2008.01.023 | |||
9967878 | 85113 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 342 | 4 | 2 | 3 | 3.9 | Fc1ccc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)cc1F | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL224510 | 85113 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 342 | 4 | 2 | 3 | 3.9 | Fc1ccc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)cc1F | 10.1016/j.bmc.2006.09.052 | |||
44421867 | 85191 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 312 | 4 | 2 | 4 | 3.7 | c1cc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)cs1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL225166 | 85191 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 312 | 4 | 2 | 4 | 3.7 | c1cc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)cs1 | 10.1016/j.bmc.2006.09.052 | |||
44421889 | 85253 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 307 | 4 | 1 | 3 | 3.6 | c1ccc(CN2CCCC(Oc3ccc4[nH]ncc4c3)C2)cc1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL225582 | 85253 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 307 | 4 | 1 | 3 | 3.6 | c1ccc(CN2CCCC(Oc3ccc4[nH]ncc4c3)C2)cc1 | 10.1016/j.bmc.2006.09.052 | |||
21098519 | 85264 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 336 | 5 | 2 | 4 | 3.6 | COc1ccc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)cc1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL225637 | 85264 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 336 | 5 | 2 | 4 | 3.6 | COc1ccc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)cc1 | 10.1016/j.bmc.2006.09.052 | |||
21098523 | 142376 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 320 | 4 | 2 | 3 | 3.9 | Cc1ccc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)cc1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL388516 | 142376 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 320 | 4 | 2 | 3 | 3.9 | Cc1ccc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)cc1 | 10.1016/j.bmc.2006.09.052 | |||
44421913 | 161978 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 334 | 4 | 2 | 3 | 3.4 | O=C(Nc1ccc2[nH]ncc2c1)C1CCCN(Cc2ccccc2)C1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL415061 | 161978 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 334 | 4 | 2 | 3 | 3.4 | O=C(Nc1ccc2[nH]ncc2c1)C1CCCN(Cc2ccccc2)C1 | 10.1016/j.bmc.2006.09.052 | |||
21098488 | 166362 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 340 | 4 | 2 | 3 | 4.3 | Clc1ccc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)cc1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL426925 | 166362 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 340 | 4 | 2 | 3 | 4.3 | Clc1ccc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)cc1 | 10.1016/j.bmc.2006.09.052 | |||
21098490 | 166420 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 326 | 4 | 2 | 3 | 3.9 | Clc1ccc(CN2CCC(Nc3ccc4[nH]ncc4c3)C2)cc1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL427245 | 166420 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 326 | 4 | 2 | 3 | 3.9 | Clc1ccc(CN2CCC(Nc3ccc4[nH]ncc4c3)C2)cc1 | 10.1016/j.bmc.2006.09.052 | |||
44421917 | 166422 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 321 | 4 | 3 | 4 | 3.2 | Nc1ccccc1CN1CCCC(Nc2ccc3[nH]ncc3c2)C1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL427254 | 166422 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 321 | 4 | 3 | 4 | 3.2 | Nc1ccccc1CN1CCCC(Nc2ccc3[nH]ncc3c2)C1 | 10.1016/j.bmc.2006.09.052 | |||
9840006 | 142113 | None | 4 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 318 | 4 | 2 | 4 | 3.5 | Nc1cccc(CN2CC[C@@H](Nc3cccc4cnccc34)C2)c1 | 10.1016/j.bmc.2006.10.028 | |||
CHEMBL387625 | 142113 | None | 4 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 318 | 4 | 2 | 4 | 3.5 | Nc1cccc(CN2CC[C@@H](Nc3cccc4cnccc34)C2)c1 | 10.1016/j.bmc.2006.10.028 | |||
9956238 | 60218 | None | 0 | Rat | Functional | pIC50 | = | 5 | 5.0 | -79 | 4 | ChEMBL | 467 | 8 | 2 | 8 | 3.0 | Cc1nn(C)c2nc(N(C)CCN(C)C)c(C(=O)NC(=O)Nc3cccc(OC(C)C)c3)cc12 | 10.1021/jm1012903 | |||
CHEMBL1688889 | 60218 | None | 0 | Rat | Functional | pIC50 | = | 5 | 5.0 | -79 | 4 | ChEMBL | 467 | 8 | 2 | 8 | 3.0 | Cc1nn(C)c2nc(N(C)CCN(C)C)c(C(=O)NC(=O)Nc3cccc(OC(C)C)c3)cc12 | 10.1021/jm1012903 | |||
CHEMBL1739922 | 60218 | None | 0 | Rat | Functional | pIC50 | = | 5 | 5.0 | -79 | 4 | ChEMBL | 467 | 8 | 2 | 8 | 3.0 | Cc1nn(C)c2nc(N(C)CCN(C)C)c(C(=O)NC(=O)Nc3cccc(OC(C)C)c3)cc12 | 10.1021/jm1012903 | |||
44453002 | 155463 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 453 | 7 | 2 | 3 | 3.9 | O=C(CCNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL403424 | 155463 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 453 | 7 | 2 | 3 | 3.9 | O=C(CCNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
44421860 | 85082 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 295 | 4 | 3 | 3 | 3.0 | c1c[nH]c(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)c1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL224166 | 85082 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 295 | 4 | 3 | 3 | 3.0 | c1c[nH]c(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)c1 | 10.1016/j.bmc.2006.09.052 | |||
9900683 | 141999 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 292 | 4 | 2 | 3 | 3.2 | c1ccc(CN2CCC(Nc3ccc4[nH]ncc4c3)C2)cc1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL386937 | 141999 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 292 | 4 | 2 | 3 | 3.2 | c1ccc(CN2CCC(Nc3ccc4[nH]ncc4c3)C2)cc1 | 10.1016/j.bmc.2006.09.052 | |||
10065796 | 142154 | None | 3 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 339 | 4 | 1 | 3 | 4.2 | Fc1cccc(F)c1CN1CCC(Nc2cccc3cnccc23)C1 | 10.1016/j.bmc.2006.10.028 | |||
CHEMBL387954 | 142154 | None | 3 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 339 | 4 | 1 | 3 | 4.2 | Fc1cccc(F)c1CN1CCC(Nc2cccc3cnccc23)C1 | 10.1016/j.bmc.2006.10.028 | |||
54585109 | 62593 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 468 | 5 | 1 | 5 | 3.7 | CC(C)[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)CC[C@@H](NC2CCOCC2)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782579 | 62593 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 468 | 5 | 1 | 5 | 3.7 | CC(C)[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)CC[C@@H](NC2CCOCC2)C1 | 10.1016/j.bmcl.2011.01.034 | |||
44453234 | 97524 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 489 | 7 | 2 | 4 | 3.7 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccc(OC(F)(F)F)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL270182 | 97524 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 489 | 7 | 2 | 4 | 3.7 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccc(OC(F)(F)F)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
22143196 | 184093 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | -3 | 2 | ChEMBL | 509 | 7 | 5 | 6 | 2.0 | CSc1ccc(C(=O)NC2CCNCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL481790 | 184093 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | -3 | 2 | ChEMBL | 509 | 7 | 5 | 6 | 2.0 | CSc1ccc(C(=O)NC2CCNCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
22143196 | 184093 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | -3 | 2 | ChEMBL | 509 | 7 | 5 | 6 | 2.0 | CSc1ccc(C(=O)NC2CCNCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
CHEMBL481790 | 184093 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | -3 | 2 | ChEMBL | 509 | 7 | 5 | 6 | 2.0 | CSc1ccc(C(=O)NC2CCNCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
44416138 | 138961 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 564 | 7 | 1 | 2 | 7.5 | C[C@H]1CN(CC[C@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCC2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2006.07.011 | |||
CHEMBL378195 | 138961 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 564 | 7 | 1 | 2 | 7.5 | C[C@H]1CN(CC[C@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCC2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2006.07.011 | |||
46927117 | 65449 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 490 | 7 | 2 | 5 | 3.4 | COc1ccc([C@H]2CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cn1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829619 | 65449 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 490 | 7 | 2 | 5 | 3.4 | COc1ccc([C@H]2CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cn1 | 10.1016/j.bmcl.2011.06.080 | |||
44453405 | 95489 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 469 | 6 | 4 | 5 | 2.6 | Nc1cc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)ccc1Cl | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL257062 | 95489 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 469 | 6 | 4 | 5 | 2.6 | Nc1cc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)ccc1Cl | 10.1016/j.bmcl.2008.02.015 | |||
44453407 | 95490 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 450 | 7 | 3 | 5 | 2.4 | COc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL257063 | 95490 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 450 | 7 | 3 | 5 | 2.4 | COc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
56675205 | 65816 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 486 | 6 | 3 | 5 | 4.2 | Cc1ccc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4n[nH]c5ccc(C(F)(F)F)cc45)C3)CC2)cn1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834788 | 65816 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 486 | 6 | 3 | 5 | 4.2 | Cc1ccc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4n[nH]c5ccc(C(F)(F)F)cc45)C3)CC2)cn1 | 10.1016/j.bmcl.2011.08.074 | |||
56671793 | 65817 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 486 | 6 | 2 | 6 | 3.9 | Cn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](c4cccnc4)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834789 | 65817 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 486 | 6 | 2 | 6 | 3.9 | Cn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](c4cccnc4)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
56671795 | 65820 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 478 | 6 | 3 | 6 | 4.0 | O=C(CNc1n[nH]c2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](c3cncs3)CC2)C1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834792 | 65820 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 478 | 6 | 3 | 6 | 4.0 | O=C(CNc1n[nH]c2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](c3cncs3)CC2)C1 | 10.1016/j.bmcl.2011.08.074 | |||
46884856 | 8346 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 566 | 8 | 2 | 4 | 3.8 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCC2CCN(C(=O)c3cc(F)ccc3F)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1092921 | 8346 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 566 | 8 | 2 | 4 | 3.8 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCC2CCN(C(=O)c3cc(F)ccc3F)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
44583280 | 172552 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 640 | 9 | 3 | 6 | 4.9 | CSc1ccc(S(=O)(=O)C[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N2CCCC2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL447937 | 172552 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 640 | 9 | 3 | 6 | 4.9 | CSc1ccc(S(=O)(=O)C[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N2CCCC2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
46885159 | 8377 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 545 | 8 | 2 | 5 | 2.4 | Cc1ccc(C(=O)N2CCN(CCN3CC[C@@H](NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cc1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1093153 | 8377 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 545 | 8 | 2 | 5 | 2.4 | Cc1ccc(C(=O)N2CCN(CCN3CC[C@@H](NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cc1 | 10.1016/j.bmcl.2010.02.072 | |||
46885160 | 8378 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 549 | 8 | 2 | 5 | 2.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCN2CCN(C(=O)c3ccc(F)cc3)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1093154 | 8378 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 549 | 8 | 2 | 5 | 2.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCN2CCN(C(=O)c3ccc(F)cc3)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
9974356 | 137678 | None | 3 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 337 | 4 | 1 | 3 | 4.6 | Clc1ccc(CN2CCC(Nc3cccc4cnccc34)C2)cc1 | 10.1016/j.bmc.2006.10.028 | |||
CHEMBL375556 | 137678 | None | 3 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 337 | 4 | 1 | 3 | 4.6 | Clc1ccc(CN2CCC(Nc3cccc4cnccc34)C2)cc1 | 10.1016/j.bmc.2006.10.028 | |||
57396726 | 68977 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 562 | 8 | 3 | 5 | 4.0 | CS(=O)(=O)c1ccc(/C=C/C(=O)N2CCC(C(NC3CCC(c4c[nH]c5ccccc45)CC3)C(N)=O)CC2)cc1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922817 | 68977 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 562 | 8 | 3 | 5 | 4.0 | CS(=O)(=O)c1ccc(/C=C/C(=O)N2CCC(C(NC3CCC(c4c[nH]c5ccccc45)CC3)C(N)=O)CC2)cc1 | 10.1016/j.bmcl.2011.09.113 | |||
44439163 | 90328 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 596 | 12 | 4 | 7 | 4.7 | COC(=O)[C@H](CCCNC(=N)N)NC(=O)CCOc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
CHEMBL238518 | 90328 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 596 | 12 | 4 | 7 | 4.7 | COC(=O)[C@H](CCCNC(=N)N)NC(=O)CCOc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
183790 | 3742 | None | 8 | Human | Functional | pIC50 | = | 7.9 | 7.9 | -1 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1016/j.bmc.2018.05.027 | |||
783 | 3742 | None | 8 | Human | Functional | pIC50 | = | 7.9 | 7.9 | -1 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1016/j.bmc.2018.05.027 | |||
CHEMBL1178786 | 3742 | None | 8 | Human | Functional | pIC50 | = | 7.9 | 7.9 | -1 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1016/j.bmc.2018.05.027 | |||
11283842 | 73764 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 522 | 13 | 5 | 5 | 4.5 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CC(=O)Nc1cc(NCC)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018402 | 73764 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 522 | 13 | 5 | 5 | 4.5 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CC(=O)Nc1cc(NCC)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2012.03.007 | |||
11353855 | 74575 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 595 | 6 | 2 | 8 | 4.2 | O=C(C1CCN(c2cc(C(F)(F)F)ccn2)CC1)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncccn4)cn3)CC2)C1 | 10.1021/ml200199c | |||
CHEMBL2029568 | 74575 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 595 | 6 | 2 | 8 | 4.2 | O=C(C1CCN(c2cc(C(F)(F)F)ccn2)CC1)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncccn4)cn3)CC2)C1 | 10.1021/ml200199c | |||
56643545 | 68982 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 520 | 7 | 3 | 3 | 4.9 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)cc(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922823 | 68982 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 520 | 7 | 3 | 3 | 4.9 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)cc(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
52943756 | 19297 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 23 | 2 | ChEMBL | 489 | 6 | 3 | 4 | 3.3 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@H]1CN([C@H]2CC[C@@H](c3ccccc3)CC2)C[C@@H]1O | 10.1016/j.bmcl.2010.10.020 | |||
CHEMBL1290412 | 19297 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 23 | 2 | ChEMBL | 489 | 6 | 3 | 4 | 3.3 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@H]1CN([C@H]2CC[C@@H](c3ccccc3)CC2)C[C@@H]1O | 10.1016/j.bmcl.2010.10.020 | |||
44453368 | 97820 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 449 | 6 | 4 | 5 | 2.3 | Cc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)cc1N | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL271725 | 97820 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 449 | 6 | 4 | 5 | 2.3 | Cc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)cc1N | 10.1016/j.bmcl.2008.02.015 | |||
56683116 | 65827 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 534 | 7 | 2 | 7 | 5.1 | CC(C)c1ncc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4nn(C)c5ccc(C(F)(F)F)cc45)C3)CC2)s1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834799 | 65827 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 534 | 7 | 2 | 7 | 5.1 | CC(C)c1ncc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4nn(C)c5ccc(C(F)(F)F)cc45)C3)CC2)s1 | 10.1016/j.bmcl.2011.08.074 | |||
46884898 | 7719 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 564 | 8 | 2 | 4 | 4.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCC2CCN(C(=O)c3ccccc3Cl)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1088874 | 7719 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 564 | 8 | 2 | 4 | 4.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCC2CCN(C(=O)c3ccccc3Cl)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
44453409 | 95492 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 419 | 6 | 2 | 3 | 3.1 | Cc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL257065 | 95492 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 419 | 6 | 2 | 3 | 3.1 | Cc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
22143146 | 184012 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 490 | 8 | 3 | 4 | 3.5 | Cc1ccc(CNC2CC(N(C)C)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
CHEMBL481202 | 184012 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 490 | 8 | 3 | 4 | 3.5 | Cc1ccc(CNC2CC(N(C)C)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
10218843 | 172889 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 633 | 11 | 3 | 6 | 5.1 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](NCc3ccccc3)CC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL451340 | 172889 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 633 | 11 | 3 | 6 | 5.1 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](NCc3ccccc3)CC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
44425641 | 86100 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 5 | 2 | ChEMBL | 596 | 6 | 1 | 3 | 7.5 | CSC[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL230832 | 86100 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 5 | 2 | ChEMBL | 596 | 6 | 1 | 3 | 7.5 | CSC[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
10007642 | 19116 | None | 0 | Mouse | Functional | pIC50 | = | 7.9 | 7.9 | -2 | 2 | ChEMBL | 547 | 8 | 3 | 5 | 3.8 | CCO[C@H]1CN([C@H]2CC[C@@](O)(c3ccc(C)cc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.10.020 | |||
CHEMBL1289203 | 19116 | None | 0 | Mouse | Functional | pIC50 | = | 7.9 | 7.9 | -2 | 2 | ChEMBL | 547 | 8 | 3 | 5 | 3.8 | CCO[C@H]1CN([C@H]2CC[C@@](O)(c3ccc(C)cc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.10.020 | |||
46885028 | 8424 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 545 | 8 | 2 | 5 | 2.4 | Cc1ccccc1C(=O)N1CCN(CCN2CC[C@@H](NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1093470 | 8424 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 545 | 8 | 2 | 5 | 2.4 | Cc1ccccc1C(=O)N1CCN(CCN2CC[C@@H](NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2010.02.072 | |||
24801523 | 97908 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 493 | 7 | 3 | 4 | 4.0 | CSc1ccc(C(=O)N[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1021/jm701488f | |||
CHEMBL272168 | 97908 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 493 | 7 | 3 | 4 | 4.0 | CSc1ccc(C(=O)N[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1021/jm701488f | |||
57656833 | 75255 | None | 0 | Mouse | Functional | pIC50 | = | 5.9 | 5.9 | -257 | 4 | ChEMBL | 427 | 3 | 2 | 4 | 2.4 | CC(C)N1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036782 | 75255 | None | 0 | Mouse | Functional | pIC50 | = | 5.9 | 5.9 | -257 | 4 | ChEMBL | 427 | 3 | 2 | 4 | 2.4 | CC(C)N1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
122181148 | 121902 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 478 | 6 | 1 | 3 | 5.2 | CC1Cc2ccccc2C2(CCN(CCCC(=O)NCc3cc(F)cc(C(F)(F)F)c3)CC2)O1 | 10.1016/j.bmc.2015.02.019 | |||
CHEMBL3589843 | 121902 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 478 | 6 | 1 | 3 | 5.2 | CC1Cc2ccccc2C2(CCN(CCCC(=O)NCc3cc(F)cc(C(F)(F)F)c3)CC2)O1 | 10.1016/j.bmc.2015.02.019 | |||
9956238 | 60218 | None | 0 | Mouse | Functional | pIC50 | = | 4.9 | 4.9 | -95 | 4 | ChEMBL | 467 | 8 | 2 | 8 | 3.0 | Cc1nn(C)c2nc(N(C)CCN(C)C)c(C(=O)NC(=O)Nc3cccc(OC(C)C)c3)cc12 | 10.1021/jm1012903 | |||
CHEMBL1688889 | 60218 | None | 0 | Mouse | Functional | pIC50 | = | 4.9 | 4.9 | -95 | 4 | ChEMBL | 467 | 8 | 2 | 8 | 3.0 | Cc1nn(C)c2nc(N(C)CCN(C)C)c(C(=O)NC(=O)Nc3cccc(OC(C)C)c3)cc12 | 10.1021/jm1012903 | |||
CHEMBL1739922 | 60218 | None | 0 | Mouse | Functional | pIC50 | = | 4.9 | 4.9 | -95 | 4 | ChEMBL | 467 | 8 | 2 | 8 | 3.0 | Cc1nn(C)c2nc(N(C)CCN(C)C)c(C(=O)NC(=O)Nc3cccc(OC(C)C)c3)cc12 | 10.1021/jm1012903 | |||
508742 | 95629 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 423 | 6 | 2 | 3 | 3.0 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL257702 | 95629 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 423 | 6 | 2 | 3 | 3.0 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccc(F)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
145963552 | 161442 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 489 | 6 | 1 | 5 | 4.1 | CC(=O)N1CCN(CCCN2CCCc3c(ccnc3Nc3ccc(Cl)c(Cl)c3)C2=O)CC1 | 10.1016/j.bmc.2018.05.027 | |||
CHEMBL4125866 | 161442 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 489 | 6 | 1 | 5 | 4.1 | CC(=O)N1CCN(CCCN2CCCc3c(ccnc3Nc3ccc(Cl)c(Cl)c3)C2=O)CC1 | 10.1016/j.bmc.2018.05.027 | |||
122181146 | 121900 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | 14 | 2 | ChEMBL | 544 | 7 | 1 | 4 | 5.7 | COc1ccc2c(c1)CCOC21CCN(CCCC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1 | 10.1016/j.bmc.2015.02.019 | |||
CHEMBL3589841 | 121900 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | 14 | 2 | ChEMBL | 544 | 7 | 1 | 4 | 5.7 | COc1ccc2c(c1)CCOC21CCN(CCCC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1 | 10.1016/j.bmc.2015.02.019 | |||
44447435 | 94749 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 514 | 9 | 1 | 2 | 7.0 | CCCC(CCN1CCC(c2ccccc2)CC1)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL252815 | 94749 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 514 | 9 | 1 | 2 | 7.0 | CCCC(CCN1CCC(c2ccccc2)CC1)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.01.023 | |||
44447435 | 94749 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 514 | 9 | 1 | 2 | 7.0 | CCCC(CCN1CCC(c2ccccc2)CC1)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL252815 | 94749 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 514 | 9 | 1 | 2 | 7.0 | CCCC(CCN1CCC(c2ccccc2)CC1)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.01.023 | |||
145962429 | 161663 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 446 | 6 | 1 | 4 | 5.4 | O=C1c2ccnc(Nc3ccc(Cl)c(Cl)c3)c2CCCN1CCCN1CCCCC1 | 10.1016/j.bmc.2018.05.027 | |||
CHEMBL4128975 | 161663 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 446 | 6 | 1 | 4 | 5.4 | O=C1c2ccnc(Nc3ccc(Cl)c(Cl)c3)c2CCCN1CCCN1CCCCC1 | 10.1016/j.bmc.2018.05.027 | |||
44453538 | 97983 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 419 | 6 | 2 | 3 | 3.1 | Cc1ccccc1CN1CC[C@@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL272543 | 97983 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 419 | 6 | 2 | 3 | 3.1 | Cc1ccccc1CN1CC[C@@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
46240482 | 83610 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 482 | 6 | 3 | 6 | 2.5 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@@](O)(c3nccs3)CC2)C1 | 10.1021/ml300260s | |||
CHEMBL2204259 | 83610 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 482 | 6 | 3 | 6 | 2.5 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@@](O)(c3nccs3)CC2)C1 | 10.1021/ml300260s | |||
22143294 | 193535 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 551 | 11 | 4 | 6 | 3.9 | CCCCN1CCC(NCc2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL526091 | 193535 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 551 | 11 | 4 | 6 | 3.9 | CCCCN1CCC(NCc2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C1 | 10.1016/j.bmcl.2008.07.123 | |||
44580590 | 193680 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 565 | 10 | 4 | 6 | 3.5 | CCCCN1CCC(NC(=O)c2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL526859 | 193680 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 565 | 10 | 4 | 6 | 3.5 | CCCCN1CCC(NC(=O)c2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C1 | 10.1016/j.bmcl.2008.07.123 | |||
70683350 | 73752 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 607 | 12 | 5 | 6 | 3.4 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)N1CCOCC1 | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018390 | 73752 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 607 | 12 | 5 | 6 | 3.4 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)N1CCOCC1 | 10.1016/j.bmcl.2012.03.007 | |||
44425641 | 86100 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 5 | 2 | ChEMBL | 596 | 6 | 1 | 3 | 7.5 | CSC[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL230832 | 86100 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 5 | 2 | ChEMBL | 596 | 6 | 1 | 3 | 7.5 | CSC[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
44425288 | 86049 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 570 | 8 | 2 | 5 | 6.4 | Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL230507 | 86049 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 570 | 8 | 2 | 5 | 6.4 | Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
44425304 | 143454 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 670 | 9 | 2 | 6 | 8.2 | CC(C)(C)OC(=O)Nc1nc([C@@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL389773 | 143454 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 670 | 9 | 2 | 6 | 8.2 | CC(C)(C)OC(=O)Nc1nc([C@@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
69035677 | 77678 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 590 | 8 | 1 | 5 | 5.6 | CCN(C(C)C)[C@@H]1CC[C@H](N2CCC(c3nc4cccc(C(F)(F)F)c4[nH]3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2012.08.002 | |||
CHEMBL2088389 | 77678 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 590 | 8 | 1 | 5 | 5.6 | CCN(C(C)C)[C@@H]1CC[C@H](N2CCC(c3nc4cccc(C(F)(F)F)c4[nH]3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2012.08.002 | |||
44425288 | 86049 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 570 | 8 | 2 | 5 | 6.4 | Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL230507 | 86049 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 570 | 8 | 2 | 5 | 6.4 | Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
44425304 | 143454 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 670 | 9 | 2 | 6 | 8.2 | CC(C)(C)OC(=O)Nc1nc([C@@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL389773 | 143454 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 670 | 9 | 2 | 6 | 8.2 | CC(C)(C)OC(=O)Nc1nc([C@@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
44571218 | 183984 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 523 | 7 | 5 | 6 | 2.5 | CSc1ccc(C(=O)NC2CC(N)CCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
CHEMBL481009 | 183984 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 523 | 7 | 5 | 6 | 2.5 | CSc1ccc(C(=O)NC2CC(N)CCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
57344310 | 68958 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 539 | 7 | 3 | 4 | 4.4 | NC(=O)C(NC1CCC(c2c[nH]c3ncccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922794 | 68958 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 539 | 7 | 3 | 4 | 4.4 | NC(=O)C(NC1CCC(c2c[nH]c3ncccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
57343820 | 68976 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 518 | 7 | 3 | 3 | 5.2 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922816 | 68976 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 518 | 7 | 3 | 3 | 5.2 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
24801525 | 97662 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 526 | 7 | 4 | 5 | 1.9 | NS(=O)(=O)c1ccc(C(=O)N[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1021/jm701488f | |||
CHEMBL270906 | 97662 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 526 | 7 | 4 | 5 | 1.9 | NS(=O)(=O)c1ccc(C(=O)N[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1021/jm701488f | |||
49763686 | 65445 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 503 | 7 | 3 | 4 | 3.7 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3ccc(C(=O)O)cc3)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829615 | 65445 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 503 | 7 | 3 | 4 | 3.7 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3ccc(C(=O)O)cc3)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
57396724 | 68969 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 485 | 7 | 2 | 3 | 4.1 | NC(=O)C(NC1CCC(c2ccccc2)C1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922805 | 68969 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 485 | 7 | 2 | 3 | 4.1 | NC(=O)C(NC1CCC(c2ccccc2)C1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
57396725 | 68971 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 498 | 7 | 3 | 3 | 4.7 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)C2CC2c2ccccc2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922808 | 68971 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 498 | 7 | 3 | 3 | 4.7 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)C2CC2c2ccccc2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
44563039 | 192154 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 482 | 5 | 1 | 3 | 5.1 | O=C(/C=C/c1cc(F)c(F)c(F)c1)N1CCC(CN2CCC(c3c[nH]c4ncccc34)CC2)CC1 | 10.1016/j.bmcl.2008.10.061 | |||
CHEMBL520228 | 192154 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 482 | 5 | 1 | 3 | 5.1 | O=C(/C=C/c1cc(F)c(F)c(F)c1)N1CCC(CN2CCC(c3c[nH]c4ncccc34)CC2)CC1 | 10.1016/j.bmcl.2008.10.061 | |||
11179439 | 73762 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 494 | 11 | 5 | 5 | 3.7 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CC(=O)Nc1cc(N)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018400 | 73762 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 494 | 11 | 5 | 5 | 3.7 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CC(=O)Nc1cc(N)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2012.03.007 | |||
46947816 | 65454 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 476 | 6 | 3 | 5 | 3.1 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3ccc(O)cn3)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829624 | 65454 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 476 | 6 | 3 | 5 | 3.1 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3ccc(O)cn3)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
44563113 | 174687 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 515 | 5 | 3 | 4 | 5.4 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCC(C(CO)N2CCC(c3c[nH]c4ncccc34)CC2)CC1 | 10.1016/j.bmcl.2008.10.061 | |||
CHEMBL455682 | 174687 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 515 | 5 | 3 | 4 | 5.4 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCC(C(CO)N2CCC(c3c[nH]c4ncccc34)CC2)CC1 | 10.1016/j.bmcl.2008.10.061 | |||
508877 | 95114 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 466 | 7 | 4 | 6 | 2.1 | COc1cc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)ccc1O | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL255209 | 95114 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 466 | 7 | 4 | 6 | 2.1 | COc1cc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)ccc1O | 10.1016/j.bmcl.2008.02.015 | |||
54756045 | 65809 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 510 | 7 | 3 | 8 | 2.3 | CCOC(=O)[C@H]1CC[C@@H](N2CC(NC(=O)CNc3nn(C(N)=O)c4ccc(C(F)(F)F)cc34)C2)CC1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834781 | 65809 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 510 | 7 | 3 | 8 | 2.3 | CCOC(=O)[C@H]1CC[C@@H](N2CC(NC(=O)CNc3nn(C(N)=O)c4ccc(C(F)(F)F)cc34)C2)CC1 | 10.1016/j.bmcl.2011.08.074 | |||
56678507 | 65821 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 492 | 6 | 2 | 7 | 4.0 | Cn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](c4cncs4)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834793 | 65821 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 492 | 6 | 2 | 7 | 4.0 | Cn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](c4cncs4)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
44447429 | 94696 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 550 | 7 | 1 | 2 | 7.1 | C[C@H]1CN(CCC(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CC2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL252412 | 94696 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 550 | 7 | 1 | 2 | 7.1 | C[C@H]1CN(CCC(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CC2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
50925394 | 19335 | None | 0 | Mouse | Functional | pIC50 | = | 7.9 | 7.9 | -2 | 2 | ChEMBL | 517 | 8 | 2 | 4 | 4.4 | CCO[C@H]1CN([C@H]2CC[C@@H](c3ccccc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.10.020 | |||
CHEMBL1290636 | 19335 | None | 0 | Mouse | Functional | pIC50 | = | 7.9 | 7.9 | -2 | 2 | ChEMBL | 517 | 8 | 2 | 4 | 4.4 | CCO[C@H]1CN([C@H]2CC[C@@H](c3ccccc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.10.020 | |||
44447429 | 94696 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 550 | 7 | 1 | 2 | 7.1 | C[C@H]1CN(CCC(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CC2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL252412 | 94696 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 550 | 7 | 1 | 2 | 7.1 | C[C@H]1CN(CCC(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CC2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
44425286 | 153336 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 670 | 9 | 2 | 6 | 8.2 | CC(C)(C)OC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL397750 | 153336 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 670 | 9 | 2 | 6 | 8.2 | CC(C)(C)OC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
44425286 | 153336 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 670 | 9 | 2 | 6 | 8.2 | CC(C)(C)OC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL397750 | 153336 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 670 | 9 | 2 | 6 | 8.2 | CC(C)(C)OC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
57344299 | 68978 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 552 | 7 | 3 | 3 | 5.6 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2ccc(C(F)(F)F)cc2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922818 | 68978 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 552 | 7 | 3 | 3 | 5.6 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2ccc(C(F)(F)F)cc2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
56669631 | 65830 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 489 | 6 | 2 | 7 | 3.3 | Cn1ccc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4nn(C)c5ccc(C(F)(F)F)cc45)C3)CC2)n1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834851 | 65830 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 489 | 6 | 2 | 7 | 3.3 | Cn1ccc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4nn(C)c5ccc(C(F)(F)F)cc45)C3)CC2)n1 | 10.1016/j.bmcl.2011.08.074 | |||
132572938 | 156881 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 551 | 8 | 1 | 4 | 6.4 | Cc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(CN(C)C4CCOCC4)cc2)CN(CC(C)C)C3=O)cc1 | 10.1016/j.ejmech.2017.04.046 | |||
CHEMBL4070869 | 156881 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 551 | 8 | 1 | 4 | 6.4 | Cc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(CN(C)C4CCOCC4)cc2)CN(CC(C)C)C3=O)cc1 | 10.1016/j.ejmech.2017.04.046 | |||
44439158 | 146915 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 542 | 10 | 1 | 4 | 7.5 | O=C(CCCc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1)NCCCc1ccncc1 | 10.1016/j.bmcl.2006.10.060 | |||
CHEMBL392493 | 146915 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 542 | 10 | 1 | 4 | 7.5 | O=C(CCCc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1)NCCCc1ccncc1 | 10.1016/j.bmcl.2006.10.060 | |||
10272003 | 58896 | None | 1 | Mouse | Functional | pIC50 | = | 5.9 | 5.9 | -2 | 3 | ChEMBL | 395 | 2 | 2 | 5 | 3.4 | Cc1nn(C)c2ncc(C(=O)NC(=O)Nc3ccc(F)c(C(F)(F)F)c3)cc12 | 10.1021/jm1012903 | |||
CHEMBL1688888 | 58896 | None | 1 | Mouse | Functional | pIC50 | = | 5.9 | 5.9 | -2 | 3 | ChEMBL | 395 | 2 | 2 | 5 | 3.4 | Cc1nn(C)c2ncc(C(=O)NC(=O)Nc3ccc(F)c(C(F)(F)F)c3)cc12 | 10.1021/jm1012903 | |||
57403700 | 68967 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 457 | 6 | 2 | 3 | 3.0 | NC(=O)C(NC1Cc2ccccc2C1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922803 | 68967 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 457 | 6 | 2 | 3 | 3.0 | NC(=O)C(NC1Cc2ccccc2C1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
10427217 | 85031 | None | 3 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 337 | 4 | 1 | 3 | 4.6 | Clc1cccc(CN2CCC(Nc3cccc4cnccc34)C2)c1 | 10.1016/j.bmc.2006.10.028 | |||
CHEMBL223815 | 85031 | None | 3 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 337 | 4 | 1 | 3 | 4.6 | Clc1cccc(CN2CCC(Nc3cccc4cnccc34)C2)c1 | 10.1016/j.bmc.2006.10.028 | |||
10041590 | 142198 | None | 3 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 318 | 4 | 2 | 4 | 3.5 | Nc1ccccc1CN1CCC(Nc2cccc3cnccc23)C1 | 10.1016/j.bmc.2006.10.028 | |||
CHEMBL388285 | 142198 | None | 3 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 318 | 4 | 2 | 4 | 3.5 | Nc1ccccc1CN1CCC(Nc2cccc3cnccc23)C1 | 10.1016/j.bmc.2006.10.028 | |||
54584164 | 62588 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 504 | 6 | 1 | 7 | 3.4 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3nc(C(F)(F)F)cs3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782574 | 62588 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 504 | 6 | 1 | 7 | 3.4 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3nc(C(F)(F)F)cs3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
44595711 | 137408 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 332 | 2 | 1 | 1 | 5.1 | C[C@H]1CC=C(C(=O)O)[C@](C)(c2ccc(Cl)c(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2015.11.051 | |||
CHEMBL3752627 | 137408 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 332 | 2 | 1 | 1 | 5.1 | C[C@H]1CC=C(C(=O)O)[C@](C)(c2ccc(Cl)c(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2015.11.051 | |||
49763568 | 65436 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 503 | 6 | 2 | 5 | 3.7 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@@H](c3ccc4c(c3)OCO4)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829605 | 65436 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 503 | 6 | 2 | 5 | 3.7 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@@H](c3ccc4c(c3)OCO4)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
11752457 | 74565 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 504 | 6 | 3 | 5 | 3.2 | Cc1ccc([C@]2(O)CC[C@H](N[C@H]3CCN(C(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)nc1 | 10.1021/ml200199c | |||
CHEMBL2029417 | 74565 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 504 | 6 | 3 | 5 | 3.2 | Cc1ccc([C@]2(O)CC[C@H](N[C@H]3CCN(C(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)nc1 | 10.1021/ml200199c | |||
54755081 | 65798 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 467 | 7 | 3 | 6 | 2.9 | CCOC(=O)[C@H]1CC[C@@H](N2CC(NC(=O)CNc3n[nH]c4ccc(C(F)(F)F)cc34)C2)CC1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834719 | 65798 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 467 | 7 | 3 | 6 | 2.9 | CCOC(=O)[C@H]1CC[C@@H](N2CC(NC(=O)CNc3n[nH]c4ccc(C(F)(F)F)cc34)C2)CC1 | 10.1016/j.bmcl.2011.08.074 | |||
56671794 | 65818 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 516 | 7 | 2 | 7 | 3.9 | COc1ccc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4nn(C)c5ccc(C(F)(F)F)cc45)C3)CC2)cn1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834790 | 65818 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 516 | 7 | 2 | 7 | 3.9 | COc1ccc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4nn(C)c5ccc(C(F)(F)F)cc45)C3)CC2)cn1 | 10.1016/j.bmcl.2011.08.074 | |||
44425634 | 142105 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 2 | 2 | ChEMBL | 578 | 6 | 1 | 2 | 8.0 | CCC[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL387587 | 142105 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 2 | 2 | ChEMBL | 578 | 6 | 1 | 2 | 8.0 | CCC[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
44442599 | 93702 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | 31 | 2 | ChEMBL | 585 | 9 | 5 | 5 | 3.3 | Cc1cc(Br)ccc1CNC[C@H](NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1N)C(=O)NC(C)(C)C | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL246804 | 93702 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | 31 | 2 | ChEMBL | 585 | 9 | 5 | 5 | 3.3 | Cc1cc(Br)ccc1CNC[C@H](NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1N)C(=O)NC(C)(C)C | 10.1016/j.bmcl.2007.07.028 | |||
10291634 | 58894 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 352 | 2 | 2 | 4 | 3.7 | O=C(NC(=O)c1ccc2c(c1)OCO2)Nc1ccc(Cl)c(Cl)c1 | 10.1021/jm1012903 | |||
CHEMBL1688879 | 58894 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 352 | 2 | 2 | 4 | 3.7 | O=C(NC(=O)c1ccc2c(c1)OCO2)Nc1ccc(Cl)c(Cl)c1 | 10.1021/jm1012903 | |||
10154979 | 58895 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 352 | 2 | 2 | 4 | 3.4 | O=C(NC(=O)c1ccc2c(c1)OCO2)Nc1cccc(C(F)(F)F)c1 | 10.1021/jm1012903 | |||
CHEMBL1688880 | 58895 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 352 | 2 | 2 | 4 | 3.4 | O=C(NC(=O)c1ccc2c(c1)OCO2)Nc1cccc(C(F)(F)F)c1 | 10.1021/jm1012903 | |||
10064487 | 85051 | None | 3 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 318 | 4 | 2 | 4 | 3.5 | Nc1ccc(CN2CCC(Nc3cccc4cnccc34)C2)cc1 | 10.1016/j.bmc.2006.10.028 | |||
CHEMBL223907 | 85051 | None | 3 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 318 | 4 | 2 | 4 | 3.5 | Nc1ccc(CN2CCC(Nc3cccc4cnccc34)C2)cc1 | 10.1016/j.bmc.2006.10.028 | |||
11585168 | 90722 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 594 | 15 | 1 | 5 | 8.2 | CCCC(CCCN(CC)CC)NC(=O)CCOc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
CHEMBL239143 | 90722 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 594 | 15 | 1 | 5 | 8.2 | CCCC(CCCN(CC)CC)NC(=O)CCOc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
57402219 | 71032 | None | 0 | Mouse | Functional | pIC50 | = | 6.8 | 6.8 | -52 | 2 | ChEMBL | 503 | 6 | 3 | 4 | 3.8 | Cc1ccc([C@]2(O)CC[C@H](N3CC[C@@H](NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cc1 | 10.1021/ml200030q | |||
CHEMBL1951766 | 71032 | None | 0 | Mouse | Functional | pIC50 | = | 6.8 | 6.8 | -52 | 2 | ChEMBL | 503 | 6 | 3 | 4 | 3.8 | Cc1ccc([C@]2(O)CC[C@H](N3CC[C@@H](NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cc1 | 10.1021/ml200030q | |||
145961260 | 161525 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 476 | 7 | 1 | 5 | 5.0 | COC1CCN(CCCN2CCCc3c(ccnc3Nc3ccc(Cl)c(Cl)c3)C2=O)CC1 | 10.1016/j.bmc.2018.05.027 | |||
CHEMBL4127096 | 161525 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 476 | 7 | 1 | 5 | 5.0 | COC1CCN(CCCN2CCCc3c(ccnc3Nc3ccc(Cl)c(Cl)c3)C2=O)CC1 | 10.1016/j.bmc.2018.05.027 | |||
52941377 | 19336 | None | 0 | Mouse | Functional | pIC50 | = | 6.8 | 6.8 | -7 | 2 | ChEMBL | 531 | 9 | 2 | 4 | 4.8 | CCCO[C@H]1CN([C@H]2CC[C@@H](c3ccccc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.10.020 | |||
CHEMBL1290637 | 19336 | None | 0 | Mouse | Functional | pIC50 | = | 6.8 | 6.8 | -7 | 2 | ChEMBL | 531 | 9 | 2 | 4 | 4.8 | CCCO[C@H]1CN([C@H]2CC[C@@H](c3ccccc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.10.020 | |||
57394970 | 68965 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 465 | 7 | 2 | 3 | 4.0 | CC(C)C1CCC(NC(C(N)=O)C2CCN(C(=O)/C=C/c3cc(F)c(F)c(F)c3)CC2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922800 | 68965 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 465 | 7 | 2 | 3 | 4.0 | CC(C)C1CCC(NC(C(N)=O)C2CCN(C(=O)/C=C/c3cc(F)c(F)c(F)c3)CC2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
44583282 | 172798 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 656 | 9 | 3 | 7 | 4.2 | CSc1ccc(S(=O)(=O)C[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N2CCOCC2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL450231 | 172798 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 656 | 9 | 3 | 7 | 4.2 | CSc1ccc(S(=O)(=O)C[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N2CCOCC2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
53389660 | 171586 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 300 | 3 | 1 | 4 | 2.5 | O=c1c(Cc2cccc(Cl)c2)c(C2CC2)[nH]c2ncnn12 | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4463626 | 171586 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 300 | 3 | 1 | 4 | 2.5 | O=c1c(Cc2cccc(Cl)c2)c(C2CC2)[nH]c2ncnn12 | 10.1021/acs.jmedchem.9b00742 | |||
53389845 | 173064 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 45 | 2 | ChEMBL | 315 | 3 | 2 | 5 | 2.1 | Nc1nc2[nH]c(C3CC3)c(Cc3cccc(Cl)c3)c(=O)n2n1 | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4517518 | 173064 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 45 | 2 | ChEMBL | 315 | 3 | 2 | 5 | 2.1 | Nc1nc2[nH]c(C3CC3)c(Cc3cccc(Cl)c3)c(=O)n2n1 | 10.1021/acs.jmedchem.9b00742 | |||
57344303 | 68953 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 538 | 7 | 3 | 3 | 5.0 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922789 | 68953 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 538 | 7 | 3 | 3 | 5.0 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
44353447 | 3775 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 433 | 6 | 2 | 3 | 3.4 | O=C(N[C@@H]1CCN(C1)Cc1ccc(cc1C)C)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1016/j.bmcl.2008.02.015 | |||
785 | 3775 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 433 | 6 | 2 | 3 | 3.4 | O=C(N[C@@H]1CCN(C1)Cc1ccc(cc1C)C)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL337246 | 3775 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 433 | 6 | 2 | 3 | 3.4 | O=C(N[C@@H]1CCN(C1)Cc1ccc(cc1C)C)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1016/j.bmcl.2008.02.015 | |||
44425634 | 142105 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 2 | 2 | ChEMBL | 578 | 6 | 1 | 2 | 8.0 | CCC[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL387587 | 142105 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 2 | 2 | ChEMBL | 578 | 6 | 1 | 2 | 8.0 | CCC[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
11192346 | 2024 | None | 45 | Mouse | Functional | pIC50 | = | 7.8 | 7.8 | -4 | 3 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(N1CC[C@@H](C1)NC1CCC(CC1)(O)c1ccc(cn1)c1ncccn1)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200199c | |||
9032 | 2024 | None | 45 | Mouse | Functional | pIC50 | = | 7.8 | 7.8 | -4 | 3 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(N1CC[C@@H](C1)NC1CCC(CC1)(O)c1ccc(cn1)c1ncccn1)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200199c | |||
CHEMBL2029422 | 2024 | None | 45 | Mouse | Functional | pIC50 | = | 7.8 | 7.8 | -4 | 3 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(N1CC[C@@H](C1)NC1CCC(CC1)(O)c1ccc(cn1)c1ncccn1)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200199c | |||
44583281 | 188342 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 626 | 9 | 3 | 6 | 4.5 | CSc1ccc(S(=O)(=O)C[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N2CCC2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL499467 | 188342 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 626 | 9 | 3 | 6 | 4.5 | CSc1ccc(S(=O)(=O)C[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N2CCC2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
49763575 | 65466 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 474 | 6 | 3 | 4 | 3.0 | N[C@]1(c2ccccc2)CC[C@H](N2CC(NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829637 | 65466 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 474 | 6 | 3 | 4 | 3.0 | N[C@]1(c2ccccc2)CC[C@H](N2CC(NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2011.06.080 | |||
24801522 | 161231 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 573 | 6 | 3 | 3 | 3.9 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@H]1CCCC[C@H]1NC(=O)c1ccc(I)cc1 | 10.1021/jm701488f | |||
CHEMBL411726 | 161231 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 573 | 6 | 3 | 3 | 3.9 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@H]1CCCC[C@H]1NC(=O)c1ccc(I)cc1 | 10.1021/jm701488f | |||
46884855 | 8305 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 548 | 8 | 2 | 4 | 3.7 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCC2CCN(C(=O)c3cccc(F)c3)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1092656 | 8305 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 548 | 8 | 2 | 4 | 3.7 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCC2CCN(C(=O)c3cccc(F)c3)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
122181235 | 121916 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | 5 | 2 | ChEMBL | 572 | 7 | 1 | 3 | 6.7 | CC1Cc2ccccc2C2(CCN(CCC(C(=O)NCc3cc(F)cc(C(F)(F)F)c3)c3ccc(F)cc3)CC2)O1 | 10.1016/j.bmc.2015.02.019 | |||
CHEMBL3589949 | 121916 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | 5 | 2 | ChEMBL | 572 | 7 | 1 | 3 | 6.7 | CC1Cc2ccccc2C2(CCN(CCC(C(=O)NCc3cc(F)cc(C(F)(F)F)c3)c3ccc(F)cc3)CC2)O1 | 10.1016/j.bmc.2015.02.019 | |||
9923015 | 58893 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 318 | 2 | 2 | 4 | 3.0 | O=C(NC(=O)c1ccc2c(c1)OCO2)Nc1cccc(Cl)c1 | 10.1021/jm1012903 | |||
CHEMBL1688878 | 58893 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 318 | 2 | 2 | 4 | 3.0 | O=C(NC(=O)c1ccc2c(c1)OCO2)Nc1cccc(Cl)c1 | 10.1021/jm1012903 | |||
11582651 | 75229 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 424 | 5 | 1 | 3 | 4.3 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(C[C@@H]2CCCN(CC3CC3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036754 | 75229 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 424 | 5 | 1 | 3 | 4.3 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(C[C@@H]2CCCN(CC3CC3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
145961759 | 161624 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 566 | 6 | 1 | 5 | 7.1 | O=C1c2ccnc(Nc3ccc(Cl)c(Cl)c3)c2CCCN1CCCN1CCC2(CC1)SCc1ccccc12 | 10.1016/j.bmc.2018.05.027 | |||
CHEMBL4128487 | 161624 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 566 | 6 | 1 | 5 | 7.1 | O=C1c2ccnc(Nc3ccc(Cl)c(Cl)c3)c2CCCN1CCCN1CCC2(CC1)SCc1ccccc12 | 10.1016/j.bmc.2018.05.027 | |||
57656921 | 75239 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 420 | 4 | 1 | 3 | 3.5 | O=C(Nc1ccc(Br)cc1)N1CCN(C[C@@H]2CCCN(C3CC3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036764 | 75239 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 420 | 4 | 1 | 3 | 3.5 | O=C(Nc1ccc(Br)cc1)N1CCN(C[C@@H]2CCCN(C3CC3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
122181152 | 121771 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | 25 | 2 | ChEMBL | 638 | 8 | 1 | 4 | 7.2 | COc1ccc2c(c1)CCOC21CCN(CCC(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccc(F)cc2)CC1 | 10.1016/j.bmc.2015.02.019 | |||
CHEMBL3588870 | 121771 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | 25 | 2 | ChEMBL | 638 | 8 | 1 | 4 | 7.2 | COc1ccc2c(c1)CCOC21CCN(CCC(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccc(F)cc2)CC1 | 10.1016/j.bmc.2015.02.019 | |||
46241610 | 83603 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 548 | 7 | 3 | 6 | 3.6 | CC(C)(C)Oc1ccc([C@]2(O)CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cn1 | 10.1021/ml300260s | |||
CHEMBL2204252 | 83603 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 548 | 7 | 3 | 6 | 3.6 | CC(C)(C)Oc1ccc([C@]2(O)CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cn1 | 10.1021/ml300260s | |||
122181238 | 121919 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 194 | 2 | ChEMBL | 554 | 7 | 1 | 3 | 6.3 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC2(CC1)OCCc1ccccc12)C1CC1 | 10.1016/j.bmc.2015.02.019 | |||
CHEMBL3589952 | 121919 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 194 | 2 | ChEMBL | 554 | 7 | 1 | 3 | 6.3 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC2(CC1)OCCc1ccccc12)C1CC1 | 10.1016/j.bmc.2015.02.019 | |||
10304021 | 73746 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 594 | 12 | 5 | 6 | 4.8 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)OC(C)(C)C | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018384 | 73746 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 594 | 12 | 5 | 6 | 4.8 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)OC(C)(C)C | 10.1016/j.bmcl.2012.03.007 | |||
11504634 | 186142 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 526 | 6 | 2 | 4 | 4.6 | O=C(O)C(C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1)N1CCC(c2c[nH]c3ncccc23)CC1 | 10.1016/j.bmcl.2008.10.061 | |||
CHEMBL487070 | 186142 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 526 | 6 | 2 | 4 | 4.6 | O=C(O)C(C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1)N1CCC(c2c[nH]c3ncccc23)CC1 | 10.1016/j.bmcl.2008.10.061 | |||
56678508 | 65822 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 492 | 6 | 2 | 7 | 4.0 | Cn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](c4nccs4)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834794 | 65822 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 492 | 6 | 2 | 7 | 4.0 | Cn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](c4nccs4)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
44570718 | 183939 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 533 | 9 | 4 | 5 | 3.2 | CC(=O)Nc1ccc(CNC2CC(N(C)C)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
CHEMBL480621 | 183939 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 533 | 9 | 4 | 5 | 3.2 | CC(=O)Nc1ccc(CNC2CC(N(C)C)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
44580590 | 193680 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 565 | 10 | 4 | 6 | 3.5 | CCCCN1CCC(NC(=O)c2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL526859 | 193680 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 565 | 10 | 4 | 6 | 3.5 | CCCCN1CCC(NC(=O)c2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C1 | 10.1016/j.bmcl.2008.07.123 | |||
46944853 | 65451 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 490 | 7 | 2 | 5 | 3.4 | COc1cc([C@H]2CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)ccn1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829621 | 65451 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 490 | 7 | 2 | 5 | 3.4 | COc1cc([C@H]2CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)ccn1 | 10.1016/j.bmcl.2011.06.080 | |||
49763574 | 65465 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 477 | 6 | 2 | 3 | 4.0 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@](F)(c3ccccc3)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829636 | 65465 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 477 | 6 | 2 | 3 | 4.0 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@](F)(c3ccccc3)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
54755083 | 65765 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 488 | 6 | 3 | 6 | 3.1 | O=C(CNc1n[nH]c2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](n3ccccc3=O)CC2)C1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834636 | 65765 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 488 | 6 | 3 | 6 | 3.1 | O=C(CNc1n[nH]c2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](n3ccccc3=O)CC2)C1 | 10.1016/j.bmcl.2011.08.074 | |||
46885029 | 8251 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 545 | 8 | 2 | 5 | 2.4 | Cc1cccc(C(=O)N2CCN(CCN3CC[C@@H](NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)c1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1092343 | 8251 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 545 | 8 | 2 | 5 | 2.4 | Cc1cccc(C(=O)N2CCN(CCN3CC[C@@H](NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)c1 | 10.1016/j.bmcl.2010.02.072 | |||
10315045 | 143662 | None | 4 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 337 | 4 | 1 | 3 | 4.6 | Clc1ccccc1CN1CCC(Nc2cccc3cnccc23)C1 | 10.1016/j.bmc.2006.10.028 | |||
CHEMBL389926 | 143662 | None | 4 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 337 | 4 | 1 | 3 | 4.6 | Clc1ccccc1CN1CCC(Nc2cccc3cnccc23)C1 | 10.1016/j.bmc.2006.10.028 | |||
122181153 | 121906 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | 20 | 2 | ChEMBL | 558 | 7 | 1 | 3 | 6.3 | O=C(NCc1cc(F)cc(C(F)(F)F)c1)C(CCN1CCC2(CC1)OCCc1ccccc12)c1ccc(F)cc1 | 10.1016/j.bmc.2015.02.019 | |||
CHEMBL3589847 | 121906 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | 20 | 2 | ChEMBL | 558 | 7 | 1 | 3 | 6.3 | O=C(NCc1cc(F)cc(C(F)(F)F)c1)C(CCN1CCC2(CC1)OCCc1ccccc12)c1ccc(F)cc1 | 10.1016/j.bmc.2015.02.019 | |||
44416274 | 158646 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 510 | 6 | 1 | 2 | 6.4 | C[C@H]1CN(CCCC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL409162 | 158646 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 510 | 6 | 1 | 2 | 6.4 | C[C@H]1CN(CCCC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
10346048 | 78263 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 505 | 8 | 2 | 3 | 5.3 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](NCCN1CCCCC1)c1ccc(F)cc1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL210606 | 78263 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 505 | 8 | 2 | 3 | 5.3 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](NCCN1CCCCC1)c1ccc(F)cc1 | 10.1016/j.bmcl.2008.01.023 | |||
145962546 | 161504 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 537 | 8 | 1 | 6 | 3.8 | CN(C1CCN(CCCN2CCCc3c(ccnc3Nc3ccc(Cl)c(F)c3)C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
CHEMBL4126779 | 161504 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 537 | 8 | 1 | 6 | 3.8 | CN(C1CCN(CCCN2CCCc3c(ccnc3Nc3ccc(Cl)c(F)c3)C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
11553070 | 75226 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 398 | 4 | 1 | 3 | 3.9 | CCN1CCC[C@@H](CN2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036751 | 75226 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 398 | 4 | 1 | 3 | 3.9 | CCN1CCC[C@@H](CN2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
10346048 | 78263 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 505 | 8 | 2 | 3 | 5.3 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](NCCN1CCCCC1)c1ccc(F)cc1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL210606 | 78263 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 505 | 8 | 2 | 3 | 5.3 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](NCCN1CCCCC1)c1ccc(F)cc1 | 10.1016/j.bmcl.2008.01.023 | |||
11563451 | 152007 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 608 | 15 | 1 | 5 | 8.4 | CCN(CC)CCCC(CC(C)C)NC(=O)CCOc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
CHEMBL396621 | 152007 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 608 | 15 | 1 | 5 | 8.4 | CCN(CC)CCCC(CC(C)C)NC(=O)CCOc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
24801690 | 98094 | None | 20 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 95 | 5 | ChEMBL | 593 | 9 | 5 | 5 | 4.5 | CSc1ccc(C(=O)N[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL273083 | 98094 | None | 20 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 95 | 5 | ChEMBL | 593 | 9 | 5 | 5 | 4.5 | CSc1ccc(C(=O)N[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
70689914 | 74578 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 552 | 6 | 2 | 9 | 3.0 | N#Cc1ccnc(N2CCC(C(=O)N3CC[C@H](N[C@H]4CC[C@@](O)(c5ccc(-c6ncccn6)cn5)CC4)C3)CC2)c1 | 10.1021/ml200199c | |||
CHEMBL2029571 | 74578 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 552 | 6 | 2 | 9 | 3.0 | N#Cc1ccnc(N2CCC(C(=O)N3CC[C@H](N[C@H]4CC[C@@](O)(c5ccc(-c6ncccn6)cn5)CC4)C3)CC2)c1 | 10.1021/ml200199c | |||
24801690 | 98094 | None | 20 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 95 | 5 | ChEMBL | 593 | 9 | 5 | 5 | 4.5 | CSc1ccc(C(=O)N[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)cc1 | 10.1021/jm701488f | |||
CHEMBL273083 | 98094 | None | 20 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 95 | 5 | ChEMBL | 593 | 9 | 5 | 5 | 4.5 | CSc1ccc(C(=O)N[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)cc1 | 10.1021/jm701488f | |||
44453366 | 158396 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 451 | 6 | 5 | 6 | 1.7 | Nc1cc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)ccc1O | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL408908 | 158396 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 451 | 6 | 5 | 6 | 1.7 | Nc1cc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)ccc1O | 10.1016/j.bmcl.2008.02.015 | |||
46885027 | 8423 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 531 | 8 | 2 | 5 | 2.1 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCN2CCN(C(=O)c3ccccc3)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1093469 | 8423 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 531 | 8 | 2 | 5 | 2.1 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCN2CCN(C(=O)c3ccccc3)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
53322810 | 58489 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 2 | 2 | ChEMBL | 499 | 6 | 1 | 7 | 2.7 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3nccc(C(F)(F)F)n3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1683075 | 58489 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 2 | 2 | ChEMBL | 499 | 6 | 1 | 7 | 2.7 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3nccc(C(F)(F)F)n3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
54585107 | 62581 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 498 | 6 | 1 | 6 | 3.3 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3ccnc(C(F)(F)F)c3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782567 | 62581 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 498 | 6 | 1 | 6 | 3.3 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3ccnc(C(F)(F)F)c3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
54580188 | 62587 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 504 | 6 | 1 | 7 | 3.4 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3ncc(C(F)(F)F)s3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782573 | 62587 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 504 | 6 | 1 | 7 | 3.4 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3ncc(C(F)(F)F)s3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
53325639 | 58487 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 1 | 2 | ChEMBL | 498 | 6 | 1 | 6 | 3.3 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cccc(C(F)(F)F)n3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1683073 | 58487 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 1 | 2 | ChEMBL | 498 | 6 | 1 | 6 | 3.3 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cccc(C(F)(F)F)n3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
122181147 | 121901 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 464 | 6 | 1 | 3 | 4.8 | O=C(CCCN1CCC2(CC1)OCCc1ccccc12)NCc1cc(F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2015.02.019 | |||
CHEMBL3589842 | 121901 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 464 | 6 | 1 | 3 | 4.8 | O=C(CCCN1CCC2(CC1)OCCc1ccccc12)NCc1cc(F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2015.02.019 | |||
11670910 | 88656 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 524 | 6 | 2 | 3 | 4.6 | NC(=O)C(C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1)N1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL235657 | 88656 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 524 | 6 | 2 | 3 | 4.6 | NC(=O)C(C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1)N1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
145961961 | 161590 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 553 | 8 | 1 | 6 | 4.0 | CN(C1CCN(CCCN2CCCc3c(ccnc3Nc3cccc(C(F)(F)F)c3)C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
CHEMBL4128015 | 161590 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 553 | 8 | 1 | 6 | 4.0 | CN(C1CCN(CCCN2CCCc3c(ccnc3Nc3cccc(C(F)(F)F)c3)C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
57656640 | 75237 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 390 | 4 | 1 | 3 | 3.7 | Cc1ccc(NC(=O)N2CCN(C[C@@H]3CCCN(C4CC4)C3)CC2)cc1Cl | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036762 | 75237 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 390 | 4 | 1 | 3 | 3.7 | Cc1ccc(NC(=O)N2CCN(C[C@@H]3CCCN(C4CC4)C3)CC2)cc1Cl | 10.1016/j.bmcl.2012.04.118 | |||
44439155 | 92008 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | -3 | 2 | ChEMBL | 594 | 12 | 4 | 6 | 5.2 | COC(=O)[C@H](CCCNC(=N)N)NC(=O)CCCc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
CHEMBL241497 | 92008 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | -3 | 2 | ChEMBL | 594 | 12 | 4 | 6 | 5.2 | COC(=O)[C@H](CCCNC(=N)N)NC(=O)CCCc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
46885269 | 7905 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 545 | 8 | 2 | 5 | 2.5 | CC(CN1CCN(C(=O)c2ccccc2)CC1)N1CC[C@@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1090148 | 7905 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 545 | 8 | 2 | 5 | 2.5 | CC(CN1CCN(C(=O)c2ccccc2)CC1)N1CC[C@@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
56643545 | 68982 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 520 | 7 | 3 | 3 | 4.9 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)cc(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922823 | 68982 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 520 | 7 | 3 | 3 | 4.9 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)cc(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
57398494 | 68980 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 527 | 8 | 3 | 4 | 4.7 | CN(C)c1ccc(/C=C/C(=O)N2CCC(C(NC3CCC(c4c[nH]c5ccccc45)CC3)C(N)=O)CC2)cc1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922820 | 68980 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 527 | 8 | 3 | 4 | 4.7 | CN(C)c1ccc(/C=C/C(=O)N2CCC(C(NC3CCC(c4c[nH]c5ccccc45)CC3)C(N)=O)CC2)cc1 | 10.1016/j.bmcl.2011.09.113 | |||
22143104 | 188164 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 483 | 7 | 5 | 5 | 2.3 | Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)NC1CNCCC1NCc1ccc(Cl)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL497780 | 188164 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 483 | 7 | 5 | 5 | 2.3 | Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)NC1CNCCC1NCc1ccc(Cl)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
22143294 | 193535 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 551 | 11 | 4 | 6 | 3.9 | CCCCN1CCC(NCc2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL526091 | 193535 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 551 | 11 | 4 | 6 | 3.9 | CCCCN1CCC(NCc2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C1 | 10.1016/j.bmcl.2008.07.123 | |||
44571257 | 191203 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 518 | 9 | 3 | 4 | 4.3 | CC(C)c1ccc(CNC2CC(N(C)C)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
CHEMBL518772 | 191203 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 518 | 9 | 3 | 4 | 4.3 | CC(C)c1ccc(CNC2CC(N(C)C)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
11192346 | 2024 | None | 45 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 1 | 3 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(N1CC[C@@H](C1)NC1CCC(CC1)(O)c1ccc(cn1)c1ncccn1)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200199c | |||
9032 | 2024 | None | 45 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 1 | 3 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(N1CC[C@@H](C1)NC1CCC(CC1)(O)c1ccc(cn1)c1ncccn1)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200199c | |||
CHEMBL2029422 | 2024 | None | 45 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 1 | 3 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(N1CC[C@@H](C1)NC1CCC(CC1)(O)c1ccc(cn1)c1ncccn1)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200199c | |||
56661444 | 65796 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 614 | 6 | 3 | 8 | 5.1 | CC(C)(C)NC(=O)n1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](c4ccc5c(c4)OCO5)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834717 | 65796 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 614 | 6 | 3 | 8 | 5.1 | CC(C)(C)NC(=O)n1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](c4ccc5c(c4)OCO5)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
44425637 | 86021 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 3 | 2 | ChEMBL | 604 | 6 | 1 | 2 | 8.4 | C[C@H]1CN([C@@H]2CC[C@](CC3CCC3)(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL230405 | 86021 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 3 | 2 | ChEMBL | 604 | 6 | 1 | 2 | 8.4 | C[C@H]1CN([C@@H]2CC[C@](CC3CCC3)(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
44425637 | 86021 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 3 | 2 | ChEMBL | 604 | 6 | 1 | 2 | 8.4 | C[C@H]1CN([C@@H]2CC[C@](CC3CCC3)(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL230405 | 86021 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 3 | 2 | ChEMBL | 604 | 6 | 1 | 2 | 8.4 | C[C@H]1CN([C@@H]2CC[C@](CC3CCC3)(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
44425629 | 86060 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 536 | 4 | 1 | 2 | 6.8 | C[C@H]1CN([C@@H]2CC[C@H](C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL230616 | 86060 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 536 | 4 | 1 | 2 | 6.8 | C[C@H]1CN([C@@H]2CC[C@H](C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
44442593 | 147288 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 549 | 11 | 5 | 5 | 3.7 | CCNc1cc(C(=O)NCC(=O)N[C@@H](CNCc2ccc(C)cc2C)C(=O)NC(C)(C)C)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL392814 | 147288 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 549 | 11 | 5 | 5 | 3.7 | CCNc1cc(C(=O)NCC(=O)N[C@@H](CNCc2ccc(C)cc2C)C(=O)NC(C)(C)C)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.07.028 | |||
57344218 | 68970 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 484 | 7 | 3 | 3 | 4.6 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2ccccc2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922806 | 68970 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 484 | 7 | 3 | 3 | 4.6 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2ccccc2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
44563038 | 186145 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 554 | 7 | 1 | 5 | 5.0 | CCOC(=O)C(C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1)N1CCC(c2c[nH]c3ncccc23)CC1 | 10.1016/j.bmcl.2008.10.061 | |||
CHEMBL487074 | 186145 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 554 | 7 | 1 | 5 | 5.0 | CCOC(=O)C(C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1)N1CCC(c2c[nH]c3ncccc23)CC1 | 10.1016/j.bmcl.2008.10.061 | |||
21098512 | 85123 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 351 | 5 | 2 | 5 | 3.5 | O=[N+]([O-])c1cccc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)c1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL224594 | 85123 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 351 | 5 | 2 | 5 | 3.5 | O=[N+]([O-])c1cccc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)c1 | 10.1016/j.bmc.2006.09.052 | |||
21098530 | 143646 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 351 | 5 | 2 | 5 | 3.5 | O=[N+]([O-])c1ccc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)cc1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL389915 | 143646 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 351 | 5 | 2 | 5 | 3.5 | O=[N+]([O-])c1ccc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)cc1 | 10.1016/j.bmc.2006.09.052 | |||
44447426 | 94662 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 536 | 8 | 1 | 2 | 7.0 | C=CCC(CCN1CCC2(C=Cc3ccccc32)CC1)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL252208 | 94662 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 536 | 8 | 1 | 2 | 7.0 | C=CCC(CCN1CCC2(C=Cc3ccccc32)CC1)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.01.023 | |||
145961667 | 161448 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 461 | 6 | 1 | 5 | 4.2 | CN1CCN(CCCN2CCCc3c(ccnc3Nc3ccc(Cl)c(Cl)c3)C2=O)CC1 | 10.1016/j.bmc.2018.05.027 | |||
CHEMBL4126007 | 161448 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 461 | 6 | 1 | 5 | 4.2 | CN1CCN(CCCN2CCCc3c(ccnc3Nc3ccc(Cl)c(Cl)c3)C2=O)CC1 | 10.1016/j.bmc.2018.05.027 | |||
44447426 | 94662 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 536 | 8 | 1 | 2 | 7.0 | C=CCC(CCN1CCC2(C=Cc3ccccc32)CC1)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL252208 | 94662 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 536 | 8 | 1 | 2 | 7.0 | C=CCC(CCN1CCC2(C=Cc3ccccc32)CC1)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.01.023 | |||
145963369 | 161480 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 522 | 7 | 1 | 4 | 6.8 | O=C1c2ccnc(Nc3ccc(Cl)c(Cl)c3)c2CCCN1CCCN1CCC(c2ccccc2)CC1 | 10.1016/j.bmc.2018.05.027 | |||
CHEMBL4126360 | 161480 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 522 | 7 | 1 | 4 | 6.8 | O=C1c2ccnc(Nc3ccc(Cl)c(Cl)c3)c2CCCN1CCCN1CCC(c2ccccc2)CC1 | 10.1016/j.bmc.2018.05.027 | |||
11548199 | 89956 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 707 | 2 | ChEMBL | 525 | 6 | 2 | 3 | 5.2 | O=C(O)[C@H](C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1)N1CCC(c2c[nH]c3ccccc23)CC1 | 10.1021/jm070902b | |||
CHEMBL237967 | 89956 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 707 | 2 | ChEMBL | 525 | 6 | 2 | 3 | 5.2 | O=C(O)[C@H](C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1)N1CCC(c2c[nH]c3ccccc23)CC1 | 10.1021/jm070902b | |||
22143255 | 187964 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 523 | 7 | 4 | 6 | 2.4 | CSc1ccc(C(=O)NC2CCN(C)CC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL496343 | 187964 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 523 | 7 | 4 | 6 | 2.4 | CSc1ccc(C(=O)NC2CCN(C)CC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
22143155 | 188168 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 537 | 10 | 4 | 6 | 3.5 | CCCN1CCC(NCc2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL497788 | 188168 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 537 | 10 | 4 | 6 | 3.5 | CCCN1CCC(NCc2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C1 | 10.1016/j.bmcl.2008.07.123 | |||
44593555 | 188892 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 2 | ChEMBL | 642 | 10 | 4 | 6 | 4.9 | CSc1ccc(C(=O)NC2CC(NC(=O)OCc3ccccc3)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
CHEMBL505722 | 188892 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 2 | ChEMBL | 642 | 10 | 4 | 6 | 4.9 | CSc1ccc(C(=O)NC2CC(NC(=O)OCc3ccccc3)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
44570714 | 189903 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 9 | 2 | ChEMBL | 565 | 9 | 5 | 6 | 3.6 | CSc1ccc(C(=O)NC2CCC(NC(C)C)CC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
CHEMBL516224 | 189903 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 9 | 2 | ChEMBL | 565 | 9 | 5 | 6 | 3.6 | CSc1ccc(C(=O)NC2CCC(NC(C)C)CC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
9850318 | 95298 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 542 | 6 | 1 | 4 | 6.2 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CCC(c3cncnc3)CC2)C1 | 10.1016/j.bmcl.2007.12.029 | |||
CHEMBL256154 | 95298 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 542 | 6 | 1 | 4 | 6.2 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CCC(c3cncnc3)CC2)C1 | 10.1016/j.bmcl.2007.12.029 | |||
10392978 | 167557 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 558 | 6 | 2 | 5 | 5.3 | CC(C)(O)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CCC(c3cncnc3)CC2)C1 | 10.1016/j.bmcl.2007.12.029 | |||
CHEMBL429849 | 167557 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 558 | 6 | 2 | 5 | 5.3 | CC(C)(O)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CCC(c3cncnc3)CC2)C1 | 10.1016/j.bmcl.2007.12.029 | |||
54754968 | 65763 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 502 | 7 | 3 | 6 | 3.9 | COc1ccc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4n[nH]c5ccc(C(F)(F)F)cc45)C3)CC2)cn1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834634 | 65763 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 502 | 7 | 3 | 6 | 3.9 | COc1ccc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4n[nH]c5ccc(C(F)(F)F)cc45)C3)CC2)cn1 | 10.1016/j.bmcl.2011.08.074 | |||
44425647 | 86135 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 5 | 2 | ChEMBL | 542 | 6 | 1 | 2 | 7.4 | CC(C)C[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2007.04.053 | |||
CHEMBL231039 | 86135 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 5 | 2 | ChEMBL | 542 | 6 | 1 | 2 | 7.4 | CC(C)C[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2007.04.053 | |||
44423283 | 85341 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 536 | 4 | 1 | 2 | 6.8 | C[C@H]1CN([C@@H]2CC[C@H](C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC[C@@]12C=Cc1ccccc12 | 10.1021/jm070166b | |||
CHEMBL226065 | 85341 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 536 | 4 | 1 | 2 | 6.8 | C[C@H]1CN([C@@H]2CC[C@H](C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC[C@@]12C=Cc1ccccc12 | 10.1021/jm070166b | |||
44583283 | 188393 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 714 | 11 | 3 | 8 | 6.0 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)OC(C)(C)C)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL500175 | 188393 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 714 | 11 | 3 | 8 | 6.0 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)OC(C)(C)C)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
127026243 | 138356 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 456 | 3 | 2 | 6 | 2.5 | CC(C)N1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3nc(C(C)(C)C)c(Cl)s3)CC2)C1 | 10.1039/C5MD00362H | |||
CHEMBL3770591 | 138356 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 456 | 3 | 2 | 6 | 2.5 | CC(C)N1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3nc(C(C)(C)C)c(Cl)s3)CC2)C1 | 10.1039/C5MD00362H | |||
53321616 | 58477 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 5 | 2 | ChEMBL | 495 | 6 | 1 | 4 | 5.0 | CC[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cccc(C(F)(F)F)c3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.015 | |||
CHEMBL1683063 | 58477 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 5 | 2 | ChEMBL | 495 | 6 | 1 | 4 | 5.0 | CC[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cccc(C(F)(F)F)c3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.015 | |||
11433008 | 77666 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 564 | 8 | 2 | 5 | 4.9 | Cc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2NC(=O)Cc2nc3cccc(C(F)(F)F)c3[nH]2)cc1 | 10.1016/j.bmcl.2012.08.002 | |||
CHEMBL2088378 | 77666 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 564 | 8 | 2 | 5 | 4.9 | Cc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2NC(=O)Cc2nc3cccc(C(F)(F)F)c3[nH]2)cc1 | 10.1016/j.bmcl.2012.08.002 | |||
10289827 | 188082 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 571 | 9 | 2 | 6 | 3.8 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C)CC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL497202 | 188082 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 571 | 9 | 2 | 6 | 3.8 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C)CC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
25110716 | 155296 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 515 | 4 | 0 | 3 | 7.0 | C[C@H]1CN([C@@H]2CC[C@@]3(CCO[C@H]3OCc3cc(F)cc(C(F)(F)F)c3)C2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.016 | |||
CHEMBL402532 | 155296 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 515 | 4 | 0 | 3 | 7.0 | C[C@H]1CN([C@@H]2CC[C@@]3(CCO[C@H]3OCc3cc(F)cc(C(F)(F)F)c3)C2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.016 | |||
53318853 | 58473 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 27 | 2 | ChEMBL | 481 | 5 | 1 | 4 | 4.6 | CC(C)[C@]1(C(=O)N2CCN(c3cccc(C(F)(F)F)c3)CC2)CC[C@@H](N[C@H]2CCOC[C@H]2C)C1 | 10.1016/j.bmcl.2011.01.015 | |||
CHEMBL1683059 | 58473 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 27 | 2 | ChEMBL | 481 | 5 | 1 | 4 | 4.6 | CC(C)[C@]1(C(=O)N2CCN(c3cccc(C(F)(F)F)c3)CC2)CC[C@@H](N[C@H]2CCOC[C@H]2C)C1 | 10.1016/j.bmcl.2011.01.015 | |||
11597 | 674 | None | 6 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 11 | 2 | ChEMBL | 506 | 5 | 3 | 6 | 3.5 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C | 10.1021/acsmedchemlett.1c00373 | |||
23725180 | 674 | None | 6 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 11 | 2 | ChEMBL | 506 | 5 | 3 | 6 | 3.5 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C | 10.1021/acsmedchemlett.1c00373 | |||
CHEMBL4781426 | 674 | None | 6 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 11 | 2 | ChEMBL | 506 | 5 | 3 | 6 | 3.5 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C | 10.1021/acsmedchemlett.1c00373 | |||
11387511 | 74567 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 567 | 7 | 3 | 6 | 3.9 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ccncc4)cn3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
CHEMBL2029419 | 74567 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 567 | 7 | 3 | 6 | 3.9 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ccncc4)cn3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
44453441 | 97742 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 498 | 6 | 3 | 4 | 3.2 | Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@@H]1CCN(Cc2ccc(Br)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL271289 | 97742 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 498 | 6 | 3 | 4 | 3.2 | Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@@H]1CCN(Cc2ccc(Br)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
46885213 | 8462 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 52 | 3 | ChEMBL | 549 | 8 | 2 | 5 | 2.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCN2CCN(C(=O)c3ccccc3F)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1093802 | 8462 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 52 | 3 | ChEMBL | 549 | 8 | 2 | 5 | 2.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCN2CCN(C(=O)c3ccccc3F)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
57391767 | 71043 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 534 | 8 | 3 | 6 | 3.3 | CCOc1ccc([C@]2(O)CC[C@H](N3CC[C@@H](NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cn1 | 10.1021/ml200030q | |||
CHEMBL1951779 | 71043 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 534 | 8 | 3 | 6 | 3.3 | CCOc1ccc([C@]2(O)CC[C@H](N3CC[C@@H](NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cn1 | 10.1021/ml200030q | |||
127029034 | 138302 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 440 | 3 | 2 | 6 | 1.9 | CC(C)N1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3nc(C(C)(C)C)c(F)s3)CC2)C1 | 10.1039/C5MD00362H | |||
CHEMBL3770008 | 138302 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 440 | 3 | 2 | 6 | 1.9 | CC(C)N1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3nc(C(C)(C)C)c(F)s3)CC2)C1 | 10.1039/C5MD00362H | |||
11192346 | 2024 | None | 45 | Rat | Functional | pIC50 | = | 8.6 | 8.6 | -1 | 3 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(N1CC[C@@H](C1)NC1CCC(CC1)(O)c1ccc(cn1)c1ncccn1)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200199c | |||
9032 | 2024 | None | 45 | Rat | Functional | pIC50 | = | 8.6 | 8.6 | -1 | 3 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(N1CC[C@@H](C1)NC1CCC(CC1)(O)c1ccc(cn1)c1ncccn1)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200199c | |||
CHEMBL2029422 | 2024 | None | 45 | Rat | Functional | pIC50 | = | 8.6 | 8.6 | -1 | 3 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(N1CC[C@@H](C1)NC1CCC(CC1)(O)c1ccc(cn1)c1ncccn1)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200199c | |||
10300284 | 73758 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 494 | 11 | 5 | 5 | 3.1 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(N)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018396 | 73758 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 494 | 11 | 5 | 5 | 3.1 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(N)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2012.03.007 | |||
57396998 | 71038 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 491 | 6 | 3 | 6 | 2.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN([C@H]2CC[C@@](O)(c3cncnc3)CC2)C1 | 10.1021/ml200030q | |||
CHEMBL1951773 | 71038 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 491 | 6 | 3 | 6 | 2.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN([C@H]2CC[C@@](O)(c3cncnc3)CC2)C1 | 10.1021/ml200030q | |||
54755919 | 65780 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 516 | 6 | 2 | 7 | 4.5 | O=C(CNc1noc2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](c3ccc4c(c3)OCO4)CC2)C1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834651 | 65780 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 516 | 6 | 2 | 7 | 4.5 | O=C(CNc1noc2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](c3ccc4c(c3)OCO4)CC2)C1 | 10.1016/j.bmcl.2011.08.074 | |||
54755801 | 65781 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 559 | 8 | 3 | 8 | 3.7 | O=C(CNc1nn(CCO)c2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](c3ccc4c(c3)OCO4)CC2)C1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834652 | 65781 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 559 | 8 | 3 | 8 | 3.7 | O=C(CNc1nn(CCO)c2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](c3ccc4c(c3)OCO4)CC2)C1 | 10.1016/j.bmcl.2011.08.074 | |||
56659295 | 65831 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 503 | 7 | 2 | 7 | 4.2 | COc1ccc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4noc5ccc(C(F)(F)F)cc45)C3)CC2)cn1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834852 | 65831 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 503 | 7 | 2 | 7 | 4.2 | COc1ccc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4noc5ccc(C(F)(F)F)cc45)C3)CC2)cn1 | 10.1016/j.bmcl.2011.08.074 | |||
44425629 | 86060 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 536 | 4 | 1 | 2 | 6.8 | C[C@H]1CN([C@@H]2CC[C@H](C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL230616 | 86060 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 536 | 4 | 1 | 2 | 6.8 | C[C@H]1CN([C@@H]2CC[C@H](C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
9956238 | 60218 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | 3 | 4 | ChEMBL | 467 | 8 | 2 | 8 | 3.0 | Cc1nn(C)c2nc(N(C)CCN(C)C)c(C(=O)NC(=O)Nc3cccc(OC(C)C)c3)cc12 | 10.1021/jm1012903 | |||
CHEMBL1688889 | 60218 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | 3 | 4 | ChEMBL | 467 | 8 | 2 | 8 | 3.0 | Cc1nn(C)c2nc(N(C)CCN(C)C)c(C(=O)NC(=O)Nc3cccc(OC(C)C)c3)cc12 | 10.1021/jm1012903 | |||
CHEMBL1739922 | 60218 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | 3 | 4 | ChEMBL | 467 | 8 | 2 | 8 | 3.0 | Cc1nn(C)c2nc(N(C)CCN(C)C)c(C(=O)NC(=O)Nc3cccc(OC(C)C)c3)cc12 | 10.1021/jm1012903 | |||
57656833 | 75255 | None | 0 | Rat | Functional | pIC50 | = | 6.7 | 6.7 | -42 | 4 | ChEMBL | 427 | 3 | 2 | 4 | 2.4 | CC(C)N1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036782 | 75255 | None | 0 | Rat | Functional | pIC50 | = | 6.7 | 6.7 | -42 | 4 | ChEMBL | 427 | 3 | 2 | 4 | 2.4 | CC(C)N1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
44421923 | 85116 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 321 | 4 | 3 | 4 | 3.2 | Nc1ccc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)cc1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL224535 | 85116 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 321 | 4 | 3 | 4 | 3.2 | Nc1ccc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)cc1 | 10.1016/j.bmc.2006.09.052 | |||
9857714 | 85165 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 306 | 4 | 2 | 3 | 3.6 | c1ccc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)cc1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL224885 | 85165 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 306 | 4 | 2 | 3 | 3.6 | c1ccc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)cc1 | 10.1016/j.bmc.2006.09.052 | |||
44421855 | 85148 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 307 | 4 | 2 | 4 | 3.0 | c1cncc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)c1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL224746 | 85148 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 307 | 4 | 2 | 4 | 3.0 | c1cncc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)c1 | 10.1016/j.bmc.2006.09.052 | |||
11723420 | 136638 | None | 4 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 318 | 4 | 2 | 4 | 3.5 | Nc1cccc(CN2CCC(Nc3cccc4cnccc34)C2)c1 | 10.1016/j.bmc.2006.10.028 | |||
CHEMBL373759 | 136638 | None | 4 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 318 | 4 | 2 | 4 | 3.5 | Nc1cccc(CN2CCC(Nc3cccc4cnccc34)C2)c1 | 10.1016/j.bmc.2006.10.028 | |||
57656887 | 75238 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 376 | 4 | 1 | 3 | 3.4 | O=C(Nc1cccc(Cl)c1)N1CCN(C[C@@H]2CCCN(C3CC3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036763 | 75238 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 376 | 4 | 1 | 3 | 3.4 | O=C(Nc1cccc(Cl)c1)N1CCN(C[C@@H]2CCCN(C3CC3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
44447427 | 154937 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 538 | 7 | 1 | 2 | 7.1 | CC(C)C(CCN1CCC2(C=Cc3ccccc32)CC1)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL400516 | 154937 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 538 | 7 | 1 | 2 | 7.1 | CC(C)C(CCN1CCC2(C=Cc3ccccc32)CC1)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.01.023 | |||
44447427 | 154937 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 538 | 7 | 1 | 2 | 7.1 | CC(C)C(CCN1CCC2(C=Cc3ccccc32)CC1)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL400516 | 154937 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 538 | 7 | 1 | 2 | 7.1 | CC(C)C(CCN1CCC2(C=Cc3ccccc32)CC1)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.01.023 | |||
11570431 | 92016 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | -2 | 2 | ChEMBL | 564 | 13 | 1 | 4 | 7.9 | CCN(CC)CCCC(C)NC(=O)CCCc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
CHEMBL241502 | 92016 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | -2 | 2 | ChEMBL | 564 | 13 | 1 | 4 | 7.9 | CCN(CC)CCCC(C)NC(=O)CCCc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
22143346 | 172754 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 634 | 11 | 4 | 6 | 4.5 | CCCN1CCC(NCc2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N2CCCC2)C1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL449672 | 172754 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 634 | 11 | 4 | 6 | 4.5 | CCCN1CCC(NCc2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N2CCCC2)C1 | 10.1016/j.bmcl.2008.07.123 | |||
10175423 | 188553 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 614 | 10 | 4 | 6 | 4.4 | CCNC(=O)Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@H]1CCCC[C@H]1CS(=O)(=O)c1ccc(SC)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL502515 | 188553 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 614 | 10 | 4 | 6 | 4.4 | CCNC(=O)Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@H]1CCCC[C@H]1CS(=O)(=O)c1ccc(SC)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
10312346 | 188569 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 614 | 9 | 3 | 6 | 4.4 | CSc1ccc(S(=O)(=O)C[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N(C)C)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL502795 | 188569 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 614 | 9 | 3 | 6 | 4.4 | CSc1ccc(S(=O)(=O)C[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N(C)C)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
10152864 | 187980 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 543 | 8 | 3 | 6 | 3.2 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N)CC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL496432 | 187980 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 543 | 8 | 3 | 6 | 3.2 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N)CC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
49763931 | 65447 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 499 | 6 | 3 | 4 | 3.8 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3ccc4[nH]cnc4c3)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829617 | 65447 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 499 | 6 | 3 | 4 | 3.8 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3ccc4[nH]cnc4c3)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
44453330 | 95555 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 483 | 6 | 2 | 3 | 3.6 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccc(Br)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL257316 | 95555 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 483 | 6 | 2 | 3 | 3.6 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccc(Br)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
44453300 | 97489 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 451 | 7 | 2 | 4 | 3.5 | CSc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL270005 | 97489 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 451 | 7 | 2 | 4 | 3.5 | CSc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
44416274 | 158646 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 510 | 6 | 1 | 2 | 6.4 | C[C@H]1CN(CCCC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL409162 | 158646 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 510 | 6 | 1 | 2 | 6.4 | C[C@H]1CN(CCCC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
24801523 | 97908 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 493 | 7 | 3 | 4 | 4.0 | CSc1ccc(C(=O)N[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1021/jm701488f | |||
CHEMBL272168 | 97908 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 493 | 7 | 3 | 4 | 4.0 | CSc1ccc(C(=O)N[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1021/jm701488f | |||
10458152 | 77830 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 487 | 8 | 2 | 3 | 5.2 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](NCCN1CCCCC1)c1ccccc1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL209267 | 77830 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 487 | 8 | 2 | 3 | 5.2 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](NCCN1CCCCC1)c1ccccc1 | 10.1016/j.bmcl.2008.01.023 | |||
10458152 | 77830 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 487 | 8 | 2 | 3 | 5.2 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](NCCN1CCCCC1)c1ccccc1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL209267 | 77830 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 487 | 8 | 2 | 3 | 5.2 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](NCCN1CCCCC1)c1ccccc1 | 10.1016/j.bmcl.2008.01.023 | |||
49764446 | 65461 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 518 | 7 | 3 | 5 | 3.1 | CN(C)c1cccc([C@]2(O)CC[C@@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)c1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829631 | 65461 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 518 | 7 | 3 | 5 | 3.1 | CN(C)c1cccc([C@]2(O)CC[C@@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)c1 | 10.1016/j.bmcl.2011.06.080 | |||
44453474 | 97924 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 512 | 6 | 3 | 4 | 2.6 | Nc1ccc(I)cc1C(=O)NCC(=O)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL272284 | 97924 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 512 | 6 | 3 | 4 | 2.6 | Nc1ccc(I)cc1C(=O)NCC(=O)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
56659196 | 65824 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 522 | 8 | 3 | 8 | 3.4 | O=C(CNc1nn(CCO)c2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](c3nccs3)CC2)C1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834796 | 65824 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 522 | 8 | 3 | 8 | 3.4 | O=C(CNc1nn(CCO)c2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](c3nccs3)CC2)C1 | 10.1016/j.bmcl.2011.08.074 | |||
22143258 | 183985 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 522 | 9 | 3 | 5 | 3.9 | CSc1ccc(CNC2CC(N(C)C)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
CHEMBL481010 | 183985 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 522 | 9 | 3 | 5 | 3.9 | CSc1ccc(CNC2CC(N(C)C)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
57656942 | 75065 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 376 | 4 | 1 | 3 | 3.4 | O=C(Nc1ccc(Cl)cc1)N1CCN(C[C@@H]2CCCN(C3CC3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2035000 | 75065 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 376 | 4 | 1 | 3 | 3.4 | O=C(Nc1ccc(Cl)cc1)N1CCN(C[C@@H]2CCCN(C3CC3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
57403699 | 68959 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 539 | 7 | 3 | 4 | 4.4 | NC(=O)C(NC1CCC(c2c[nH]c3cnccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922795 | 68959 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 539 | 7 | 3 | 4 | 4.4 | NC(=O)C(NC1CCC(c2c[nH]c3cnccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
44453004 | 95317 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 453 | 6 | 2 | 3 | 3.9 | CC(NC(=O)c1cccc(C(F)(F)F)c1)C(=O)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL256256 | 95317 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 453 | 6 | 2 | 3 | 3.9 | CC(NC(=O)c1cccc(C(F)(F)F)c1)C(=O)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
10471319 | 84837 | None | 4 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 321 | 4 | 1 | 3 | 4.1 | Fc1ccc(CN2CCC(Nc3cccc4cnccc34)C2)cc1 | 10.1016/j.bmc.2006.10.028 | |||
CHEMBL223336 | 84837 | None | 4 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 321 | 4 | 1 | 3 | 4.1 | Fc1ccc(CN2CCC(Nc3cccc4cnccc34)C2)cc1 | 10.1016/j.bmc.2006.10.028 | |||
44439169 | 90808 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 622 | 16 | 1 | 5 | 8.8 | CCC(C)CC(CCCN(CC)CC)NC(=O)CCOc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
CHEMBL239170 | 90808 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 622 | 16 | 1 | 5 | 8.8 | CCC(C)CC(CCCN(CC)CC)NC(=O)CCOc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
44447446 | 154969 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 570 | 8 | 2 | 5 | 6.4 | Nc1nc([C@@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL400724 | 154969 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 570 | 8 | 2 | 5 | 6.4 | Nc1nc([C@@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
44447424 | 94661 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 510 | 6 | 1 | 2 | 6.4 | CC(CCN1CCC2(C=Cc3ccccc32)CC1)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL252206 | 94661 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 510 | 6 | 1 | 2 | 6.4 | CC(CCN1CCC2(C=Cc3ccccc32)CC1)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.01.023 | |||
44447446 | 154969 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 570 | 8 | 2 | 5 | 6.4 | Nc1nc([C@@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL400724 | 154969 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 570 | 8 | 2 | 5 | 6.4 | Nc1nc([C@@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
11306757 | 73763 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 508 | 12 | 5 | 5 | 4.1 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CC(=O)Nc1cc(NC)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018401 | 73763 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 508 | 12 | 5 | 5 | 4.1 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CC(=O)Nc1cc(NC)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2012.03.007 | |||
11489078 | 73831 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 509 | 12 | 4 | 5 | 4.1 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CC(=O)Nc1cc(OC)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018530 | 73831 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 509 | 12 | 4 | 5 | 4.1 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CC(=O)Nc1cc(OC)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2012.03.007 | |||
44570781 | 192674 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 515 | 8 | 4 | 4 | 3.7 | CN(C)C1CCC(NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(NCc2ccc3[nH]ccc3c2)C1 | 10.1016/j.bmcl.2008.12.062 | |||
CHEMBL521275 | 192674 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 515 | 8 | 4 | 4 | 3.7 | CN(C)C1CCC(NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(NCc2ccc3[nH]ccc3c2)C1 | 10.1016/j.bmcl.2008.12.062 | |||
46830335 | 8217 | None | 8 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 565 | 8 | 2 | 5 | 2.7 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCN2CCN(C(=O)c3ccccc3Cl)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1092238 | 8217 | None | 8 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 565 | 8 | 2 | 5 | 2.7 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCN2CCN(C(=O)c3ccccc3Cl)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
46842383 | 8347 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 530 | 8 | 2 | 4 | 3.6 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCC2CCN(C(=O)c3ccccc3)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1092929 | 8347 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 530 | 8 | 2 | 4 | 3.6 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCC2CCN(C(=O)c3ccccc3)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
70689915 | 74579 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 611 | 6 | 3 | 9 | 3.3 | O=C(N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncccn4)cn3)CC2)C1)C1(O)CCN(c2cc(C(F)(F)F)ccn2)CC1 | 10.1021/ml200199c | |||
CHEMBL2029572 | 74579 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 611 | 6 | 3 | 9 | 3.3 | O=C(N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncccn4)cn3)CC2)C1)C1(O)CCN(c2cc(C(F)(F)F)ccn2)CC1 | 10.1021/ml200199c | |||
44453472 | 155628 | None | 1 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 454 | 6 | 3 | 4 | 3.1 | Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL404259 | 155628 | None | 1 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 454 | 6 | 3 | 4 | 3.1 | Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
54586021 | 62563 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 494 | 4 | 0 | 5 | 4.1 | CC(C)[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)CC[C@@H](N2CCC3COCCC32)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782375 | 62563 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 494 | 4 | 0 | 5 | 4.1 | CC(C)[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)CC[C@@H](N2CCC3COCCC32)C1 | 10.1016/j.bmcl.2011.01.034 | |||
57396723 | 68968 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 457 | 6 | 2 | 3 | 3.5 | NC(=O)C(NC1CCc2ccccc21)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922804 | 68968 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 457 | 6 | 2 | 3 | 3.5 | NC(=O)C(NC1CCc2ccccc21)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
10360623 | 85240 | None | 4 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 351 | 4 | 1 | 3 | 5.0 | Clc1ccc(CN2CCCC(Nc3cccc4cnccc34)C2)cc1 | 10.1016/j.bmc.2006.10.028 | |||
CHEMBL225492 | 85240 | None | 4 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 351 | 4 | 1 | 3 | 5.0 | Clc1ccc(CN2CCCC(Nc3cccc4cnccc34)C2)cc1 | 10.1016/j.bmc.2006.10.028 | |||
44447424 | 94661 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 510 | 6 | 1 | 2 | 6.4 | CC(CCN1CCC2(C=Cc3ccccc32)CC1)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL252206 | 94661 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 510 | 6 | 1 | 2 | 6.4 | CC(CCN1CCC2(C=Cc3ccccc32)CC1)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.01.023 | |||
44583280 | 172552 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 640 | 9 | 3 | 6 | 4.9 | CSc1ccc(S(=O)(=O)C[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N2CCCC2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL447937 | 172552 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 640 | 9 | 3 | 6 | 4.9 | CSc1ccc(S(=O)(=O)C[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N2CCCC2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
10281316 | 73748 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | -2 | 3 | ChEMBL | 565 | 13 | 6 | 5 | 3.6 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)NCC | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018386 | 73748 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | -2 | 3 | ChEMBL | 565 | 13 | 6 | 5 | 3.6 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)NCC | 10.1016/j.bmcl.2012.03.007 | |||
44453327 | 95148 | None | 24 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 439 | 6 | 2 | 3 | 3.5 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL255408 | 95148 | None | 24 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 439 | 6 | 2 | 3 | 3.5 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
10162782 | 73732 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 479 | 11 | 4 | 4 | 3.5 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018370 | 73732 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 479 | 11 | 4 | 4 | 3.5 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2012.03.007 | |||
44442590 | 93825 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | 169 | 2 | ChEMBL | 606 | 11 | 6 | 5 | 3.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL247455 | 93825 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | 169 | 2 | ChEMBL | 606 | 11 | 6 | 5 | 3.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
49763804 | 65446 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 528 | 7 | 2 | 4 | 4.6 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3ccc(N4CCCC4)cc3)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829616 | 65446 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 528 | 7 | 2 | 4 | 4.6 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3ccc(N4CCCC4)cc3)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
11510932 | 75228 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 460 | 5 | 1 | 3 | 5.1 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(C[C@@H]2CCCN(Cc3ccccc3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036753 | 75228 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 460 | 5 | 1 | 3 | 5.1 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(C[C@@H]2CCCN(Cc3ccccc3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
145962732 | 161451 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 554 | 8 | 0 | 6 | 4.3 | CN(C1CCN(CCCN2CCCc3c(ccnc3Oc3ccc(Cl)c(Cl)c3)C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
CHEMBL4126032 | 161451 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 554 | 8 | 0 | 6 | 4.3 | CN(C1CCN(CCCN2CCCc3c(ccnc3Oc3ccc(Cl)c(Cl)c3)C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
44580591 | 187965 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 551 | 9 | 4 | 6 | 3.1 | CCCN1CCC(NC(=O)c2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(N)cc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL496344 | 187965 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 551 | 9 | 4 | 6 | 3.1 | CCCN1CCC(NC(=O)c2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(N)cc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2008.07.123 | |||
49763682 | 65442 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 489 | 7 | 2 | 4 | 4.0 | COc1ccc([C@H]2CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cc1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829612 | 65442 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 489 | 7 | 2 | 4 | 4.0 | COc1ccc([C@H]2CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cc1 | 10.1016/j.bmcl.2011.06.080 | |||
44447432 | 154938 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 564 | 8 | 1 | 2 | 7.5 | C[C@H]1CN(CCC(CC2CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL400517 | 154938 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 564 | 8 | 1 | 2 | 7.5 | C[C@H]1CN(CCC(CC2CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
44447432 | 154938 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 564 | 8 | 1 | 2 | 7.5 | C[C@H]1CN(CCC(CC2CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL400517 | 154938 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 564 | 8 | 1 | 2 | 7.5 | C[C@H]1CN(CCC(CC2CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
50991056 | 62586 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 499 | 6 | 1 | 7 | 2.7 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)cnn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782572 | 62586 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 499 | 6 | 1 | 7 | 2.7 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)cnn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
57394966 | 68949 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 495 | 6 | 2 | 2 | 6.2 | O=C(/C=C/c1cc(F)c(F)c(F)c1)N1CCC(CNC2CCC(c3c[nH]c4ccccc34)CC2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922785 | 68949 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 495 | 6 | 2 | 2 | 6.2 | O=C(/C=C/c1cc(F)c(F)c(F)c1)N1CCC(CNC2CCC(c3c[nH]c4ccccc34)CC2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
145953092 | 161432 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 539 | 8 | 1 | 6 | 3.9 | CN(C1CCN(CCCN2CCc3cnc(Nc4ccc(Cl)c(Cl)c4)cc3C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
CHEMBL4125768 | 161432 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 539 | 8 | 1 | 6 | 3.9 | CN(C1CCN(CCCN2CCc3cnc(Nc4ccc(Cl)c(Cl)c4)cc3C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
22143309 | 188047 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 537 | 10 | 4 | 6 | 3.5 | CCCN1CCC(NCc2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(N)cc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL496959 | 188047 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 537 | 10 | 4 | 6 | 3.5 | CCCN1CCC(NCc2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(N)cc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2008.07.123 | |||
10111333 | 175571 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 19 | 2 | ChEMBL | 395 | 3 | 1 | 3 | 4.3 | CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
CHEMBL4577133 | 175571 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 19 | 2 | ChEMBL | 395 | 3 | 1 | 3 | 4.3 | CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
10142792 | 93794 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | 26 | 2 | ChEMBL | 521 | 9 | 5 | 5 | 2.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL247245 | 93794 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | 26 | 2 | ChEMBL | 521 | 9 | 5 | 5 | 2.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
57656869 | 75247 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 412 | 4 | 1 | 4 | 3.0 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(C[C@H]2CN(C3CC3)CCO2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036774 | 75247 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 412 | 4 | 1 | 4 | 3.0 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(C[C@H]2CN(C3CC3)CCO2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
52943756 | 19297 | None | 0 | Mouse | Functional | pIC50 | = | 6.6 | 6.6 | -23 | 2 | ChEMBL | 489 | 6 | 3 | 4 | 3.3 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@H]1CN([C@H]2CC[C@@H](c3ccccc3)CC2)C[C@@H]1O | 10.1016/j.bmcl.2010.10.020 | |||
CHEMBL1290412 | 19297 | None | 0 | Mouse | Functional | pIC50 | = | 6.6 | 6.6 | -23 | 2 | ChEMBL | 489 | 6 | 3 | 4 | 3.3 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@H]1CN([C@H]2CC[C@@H](c3ccccc3)CC2)C[C@@H]1O | 10.1016/j.bmcl.2010.10.020 | |||
49764196 | 65463 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 519 | 6 | 3 | 6 | 2.8 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@](O)(c3ccc4c(c3)OCO4)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829633 | 65463 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 519 | 6 | 3 | 6 | 2.8 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@](O)(c3ccc4c(c3)OCO4)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
44570717 | 183938 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 544 | 8 | 3 | 4 | 4.2 | CN(C)C1CCC(NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(NCc2cccc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2008.12.062 | |||
CHEMBL480620 | 183938 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 544 | 8 | 3 | 4 | 4.2 | CN(C)C1CCC(NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(NCc2cccc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2008.12.062 | |||
56676474 | 65833 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 479 | 6 | 2 | 7 | 4.2 | O=C(CNc1noc2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](c3nccs3)CC2)C1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834854 | 65833 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 479 | 6 | 2 | 7 | 4.2 | O=C(CNc1noc2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](c3nccs3)CC2)C1 | 10.1016/j.bmcl.2011.08.074 | |||
183790 | 3742 | None | 8 | Human | Functional | pIC50 | = | 7.6 | 7.6 | -1 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1016/s0960-894x(00)00347-4 | |||
783 | 3742 | None | 8 | Human | Functional | pIC50 | = | 7.6 | 7.6 | -1 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL1178786 | 3742 | None | 8 | Human | Functional | pIC50 | = | 7.6 | 7.6 | -1 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1016/s0960-894x(00)00347-4 | |||
44425309 | 142444 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 636 | 8 | 2 | 5 | 7.0 | CC(=O)Nc1nc([C@@H](CCN2CCC3(C=Cc4ccccc43)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
CHEMBL388867 | 142444 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 636 | 8 | 2 | 5 | 7.0 | CC(=O)Nc1nc([C@@H](CCN2CCC3(C=Cc4ccccc43)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
183790 | 3742 | None | 8 | Human | Functional | pIC50 | = | 7.6 | 7.6 | -1 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1021/jm010468s | |||
783 | 3742 | None | 8 | Human | Functional | pIC50 | = | 7.6 | 7.6 | -1 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1021/jm010468s | |||
CHEMBL1178786 | 3742 | None | 8 | Human | Functional | pIC50 | = | 7.6 | 7.6 | -1 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1021/jm010468s | |||
183790 | 3742 | None | 8 | Human | Functional | pIC50 | = | 7.6 | 7.6 | -1 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1021/jm030862l | |||
783 | 3742 | None | 8 | Human | Functional | pIC50 | = | 7.6 | 7.6 | -1 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1021/jm030862l | |||
CHEMBL1178786 | 3742 | None | 8 | Human | Functional | pIC50 | = | 7.6 | 7.6 | -1 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1021/jm030862l | |||
22143334 | 187914 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 509 | 8 | 4 | 6 | 2.7 | CSc1ccc(CNC2CCN(C)CC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL495924 | 187914 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 509 | 8 | 4 | 6 | 2.7 | CSc1ccc(CNC2CCN(C)CC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
57344297 | 68975 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 502 | 7 | 3 | 3 | 4.7 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2ccccc2F)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922815 | 68975 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 502 | 7 | 3 | 3 | 4.7 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2ccccc2F)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
11711078 | 75246 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 400 | 4 | 1 | 4 | 2.9 | CCN1CCO[C@@H](CN2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036773 | 75246 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 400 | 4 | 1 | 4 | 2.9 | CCN1CCO[C@@H](CN2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
46240584 | 83613 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 532 | 6 | 3 | 6 | 3.7 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@@](O)(c3nc4ccccc4s3)CC2)C1 | 10.1021/ml300260s | |||
CHEMBL2204262 | 83613 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 532 | 6 | 3 | 6 | 3.7 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@@](O)(c3nc4ccccc4s3)CC2)C1 | 10.1021/ml300260s | |||
46944854 | 65450 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 490 | 7 | 2 | 5 | 3.4 | COc1cnccc1[C@H]1CC[C@H](N2CC(NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829620 | 65450 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 490 | 7 | 2 | 5 | 3.4 | COc1cnccc1[C@H]1CC[C@H](N2CC(NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2011.06.080 | |||
54756156 | 65806 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 507 | 9 | 2 | 7 | 3.6 | C=CCn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](C(=O)OCC)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834779 | 65806 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 507 | 9 | 2 | 7 | 3.6 | C=CCn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](C(=O)OCC)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
44447431 | 94724 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 564 | 7 | 1 | 2 | 7.5 | C[C@H]1CN(CCC(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCC2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL252611 | 94724 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 564 | 7 | 1 | 2 | 7.5 | C[C@H]1CN(CCC(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCC2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
44425642 | 142433 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 12 | 2 | ChEMBL | 582 | 5 | 1 | 3 | 7.3 | CS[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL388675 | 142433 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 12 | 2 | ChEMBL | 582 | 5 | 1 | 3 | 7.3 | CS[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
44447431 | 94724 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 564 | 7 | 1 | 2 | 7.5 | C[C@H]1CN(CCC(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCC2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL252611 | 94724 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 564 | 7 | 1 | 2 | 7.5 | C[C@H]1CN(CCC(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCC2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
44425642 | 142433 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 12 | 2 | ChEMBL | 582 | 5 | 1 | 3 | 7.3 | CS[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL388675 | 142433 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 12 | 2 | ChEMBL | 582 | 5 | 1 | 3 | 7.3 | CS[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
11678573 | 90673 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 566 | 13 | 1 | 5 | 7.4 | CCN(CC)CCCC(C)NC(=O)CCOc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
CHEMBL238936 | 90673 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 566 | 13 | 1 | 5 | 7.4 | CCN(CC)CCCC(C)NC(=O)CCOc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
57656713 | 75231 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 488 | 7 | 1 | 3 | 5.5 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(C[C@@H]2CCCN(CCCc3ccccc3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036756 | 75231 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 488 | 7 | 1 | 3 | 5.5 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(C[C@@H]2CCCN(CCCc3ccccc3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
44447433 | 94747 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 530 | 8 | 1 | 2 | 6.8 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(c2ccc(F)cc2)CC1)C1CC1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL252813 | 94747 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 530 | 8 | 1 | 2 | 6.8 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(c2ccc(F)cc2)CC1)C1CC1 | 10.1016/j.bmcl.2008.01.023 | |||
44447433 | 94747 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 530 | 8 | 1 | 2 | 6.8 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(c2ccc(F)cc2)CC1)C1CC1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL252813 | 94747 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 530 | 8 | 1 | 2 | 6.8 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(c2ccc(F)cc2)CC1)C1CC1 | 10.1016/j.bmcl.2008.01.023 | |||
22143293 | 188133 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 495 | 8 | 5 | 6 | 2.4 | CSc1ccc(CNC2CCNCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL497577 | 188133 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 495 | 8 | 5 | 6 | 2.4 | CSc1ccc(CNC2CCNCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
44447434 | 94748 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 512 | 8 | 1 | 2 | 6.6 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(c2ccccc2)CC1)C1CC1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL252814 | 94748 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 512 | 8 | 1 | 2 | 6.6 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(c2ccccc2)CC1)C1CC1 | 10.1016/j.bmcl.2008.01.023 | |||
44453535 | 155264 | None | 1 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 473 | 6 | 2 | 3 | 4.1 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccc(Cl)cc2Cl)C1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL402322 | 155264 | None | 1 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 473 | 6 | 2 | 3 | 4.1 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccc(Cl)cc2Cl)C1 | 10.1016/j.bmcl.2008.02.015 | |||
44447434 | 94748 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 512 | 8 | 1 | 2 | 6.6 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(c2ccccc2)CC1)C1CC1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL252814 | 94748 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 512 | 8 | 1 | 2 | 6.6 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(c2ccccc2)CC1)C1CC1 | 10.1016/j.bmcl.2008.01.023 | |||
155521447 | 170687 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | 3 | 2 | ChEMBL | 421 | 4 | 1 | 3 | 4.7 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1)C1CC1 | 10.1021/acs.jmedchem.8b00605 | |||
CHEMBL4450561 | 170687 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | 3 | 2 | ChEMBL | 421 | 4 | 1 | 3 | 4.7 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1)C1CC1 | 10.1021/acs.jmedchem.8b00605 | |||
11227168 | 74576 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 596 | 6 | 2 | 9 | 3.6 | O=C(C1CCN(c2nccc(C(F)(F)F)n2)CC1)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncccn4)cn3)CC2)C1 | 10.1021/ml200199c | |||
CHEMBL2029569 | 74576 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 596 | 6 | 2 | 9 | 3.6 | O=C(C1CCN(c2nccc(C(F)(F)F)n2)CC1)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncccn4)cn3)CC2)C1 | 10.1021/ml200199c | |||
46884818 | 7873 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 548 | 8 | 2 | 4 | 3.7 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCC2CCN(C(=O)c3ccccc3F)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1089881 | 7873 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 548 | 8 | 2 | 4 | 3.7 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCC2CCN(C(=O)c3ccccc3F)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
145963669 | 161653 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 553 | 8 | 1 | 6 | 4.3 | CN(C1CCN(CCCN2CCCc3c(ccnc3Nc3cc(Cl)cc(Cl)c3)C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
CHEMBL4128832 | 161653 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 553 | 8 | 1 | 6 | 4.3 | CN(C1CCN(CCCN2CCCc3c(ccnc3Nc3cc(Cl)cc(Cl)c3)C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
44416157 | 80626 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 564 | 8 | 1 | 2 | 7.5 | C[C@H]1CN(CC[C@H](CC2CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2006.07.011 | |||
CHEMBL215020 | 80626 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 564 | 8 | 1 | 2 | 7.5 | C[C@H]1CN(CC[C@H](CC2CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2006.07.011 | |||
22143309 | 188047 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 537 | 10 | 4 | 6 | 3.5 | CCCN1CCC(NCc2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(N)cc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL496959 | 188047 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 537 | 10 | 4 | 6 | 3.5 | CCCN1CCC(NCc2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(N)cc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2008.07.123 | |||
22143112 | 188552 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 594 | 11 | 5 | 6 | 3.7 | CCCN1CCC(NCc2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC)C1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL502513 | 188552 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 594 | 11 | 5 | 6 | 3.7 | CCCN1CCC(NCc2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC)C1 | 10.1016/j.bmcl.2008.07.123 | |||
57395219 | 71035 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 490 | 6 | 3 | 5 | 2.9 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN([C@H]2CC[C@@](O)(c3ccncc3)CC2)C1 | 10.1021/ml200030q | |||
CHEMBL1951770 | 71035 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 490 | 6 | 3 | 5 | 2.9 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN([C@H]2CC[C@@](O)(c3ccncc3)CC2)C1 | 10.1021/ml200030q | |||
11756884 | 19096 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 25 | 2 | ChEMBL | 533 | 8 | 3 | 5 | 3.5 | CCO[C@H]1CN([C@H]2CC[C@@](O)(c3ccccc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.10.020 | |||
CHEMBL1289083 | 19096 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 25 | 2 | ChEMBL | 533 | 8 | 3 | 5 | 3.5 | CCO[C@H]1CN([C@H]2CC[C@@](O)(c3ccccc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.10.020 | |||
54754969 | 65761 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 515 | 6 | 3 | 6 | 4.2 | O=C(CNc1n[nH]c2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](c3ccc4c(c3)OCO4)CC2)C1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834632 | 65761 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 515 | 6 | 3 | 6 | 4.2 | O=C(CNc1n[nH]c2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](c3ccc4c(c3)OCO4)CC2)C1 | 10.1016/j.bmcl.2011.08.074 | |||
44425645 | 86116 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 7 | 2 | ChEMBL | 528 | 5 | 1 | 2 | 7.0 | CC(C)[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL230933 | 86116 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 7 | 2 | ChEMBL | 528 | 5 | 1 | 2 | 7.0 | CC(C)[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
44453442 | 97743 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 434 | 6 | 3 | 4 | 2.7 | Cc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL271290 | 97743 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 434 | 6 | 3 | 4 | 2.7 | Cc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
44425645 | 86116 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 7 | 2 | ChEMBL | 528 | 5 | 1 | 2 | 7.0 | CC(C)[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL230933 | 86116 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 7 | 2 | ChEMBL | 528 | 5 | 1 | 2 | 7.0 | CC(C)[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
57395217 | 71033 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 490 | 6 | 3 | 5 | 2.9 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN([C@H]2CC[C@@](O)(c3ccccn3)CC2)C1 | 10.1021/ml200030q | |||
CHEMBL1951768 | 71033 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 490 | 6 | 3 | 5 | 2.9 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN([C@H]2CC[C@@](O)(c3ccccn3)CC2)C1 | 10.1021/ml200030q | |||
50992246 | 58488 | None | 2 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -1 | 5 | ChEMBL | 498 | 6 | 1 | 6 | 3.3 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1683074 | 58488 | None | 2 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -1 | 5 | ChEMBL | 498 | 6 | 1 | 6 | 3.3 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
50992246 | 58488 | None | 2 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -1 | 5 | ChEMBL | 498 | 6 | 1 | 6 | 3.3 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.015 | |||
CHEMBL1683074 | 58488 | None | 2 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -1 | 5 | ChEMBL | 498 | 6 | 1 | 6 | 3.3 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.015 | |||
44593561 | 12667 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 452 | 6 | 2 | 3 | 4.5 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](NC2COC2)C1 | 10.1016/j.bmcl.2008.12.050 | |||
CHEMBL1187238 | 12667 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 452 | 6 | 2 | 3 | 4.5 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](NC2COC2)C1 | 10.1016/j.bmcl.2008.12.050 | |||
CHEMBL494580 | 12667 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 452 | 6 | 2 | 3 | 4.5 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](NC2COC2)C1 | 10.1016/j.bmcl.2008.12.050 | |||
11192346 | 2024 | None | 45 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 1 | 3 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(N1CC[C@@H](C1)NC1CCC(CC1)(O)c1ccc(cn1)c1ncccn1)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200199c | |||
9032 | 2024 | None | 45 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 1 | 3 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(N1CC[C@@H](C1)NC1CCC(CC1)(O)c1ccc(cn1)c1ncccn1)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200199c | |||
CHEMBL2029422 | 2024 | None | 45 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 1 | 3 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(N1CC[C@@H](C1)NC1CCC(CC1)(O)c1ccc(cn1)c1ncccn1)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200199c | |||
67011331 | 74571 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 557 | 7 | 3 | 7 | 3.5 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncco4)cn3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
CHEMBL2029424 | 74571 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 557 | 7 | 3 | 7 | 3.5 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncco4)cn3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
44425653 | 86263 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 4 | 2 | ChEMBL | 546 | 6 | 1 | 3 | 6.7 | CSC[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL231246 | 86263 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 4 | 2 | ChEMBL | 546 | 6 | 1 | 3 | 6.7 | CSC[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
44425290 | 153620 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 628 | 9 | 2 | 6 | 7.0 | COC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL397997 | 153620 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 628 | 9 | 2 | 6 | 7.0 | COC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
11627639 | 94986 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 511 | 6 | 2 | 3 | 5.1 | O=C(/C=C/c1cc(F)c(F)c(F)c1)N1CCC([C@@H](CO)N2CCC(c3c[nH]c4ccccc34)CC2)CC1 | 10.1016/j.bmcl.2008.05.010 | |||
CHEMBL254355 | 94986 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 511 | 6 | 2 | 3 | 5.1 | O=C(/C=C/c1cc(F)c(F)c(F)c1)N1CCC([C@@H](CO)N2CCC(c3c[nH]c4ccccc34)CC2)CC1 | 10.1016/j.bmcl.2008.05.010 | |||
44425653 | 86263 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 4 | 2 | ChEMBL | 546 | 6 | 1 | 3 | 6.7 | CSC[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL231246 | 86263 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 4 | 2 | ChEMBL | 546 | 6 | 1 | 3 | 6.7 | CSC[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
44425290 | 153620 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 628 | 9 | 2 | 6 | 7.0 | COC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL397997 | 153620 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 628 | 9 | 2 | 6 | 7.0 | COC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
44453472 | 155628 | None | 1 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 454 | 6 | 3 | 4 | 3.1 | Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL404259 | 155628 | None | 1 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 454 | 6 | 3 | 4 | 3.1 | Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
24801689 | 97847 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 651 | 9 | 5 | 6 | 3.5 | NS(=O)(=O)c1ccc(C(=O)N[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)C2CCCCC2)cc1 | 10.1021/jm701488f | |||
CHEMBL271828 | 97847 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 651 | 9 | 5 | 6 | 3.5 | NS(=O)(=O)c1ccc(C(=O)N[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)C2CCCCC2)cc1 | 10.1021/jm701488f | |||
46830336 | 7852 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 567 | 8 | 2 | 5 | 2.4 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCN2CCN(C(=O)c3cc(F)ccc3F)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1089793 | 7852 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 567 | 8 | 2 | 5 | 2.4 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCN2CCN(C(=O)c3cc(F)ccc3F)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
11421712 | 74569 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4cnccn4)cn3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
CHEMBL2029421 | 74569 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4cnccn4)cn3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
10008367 | 2022 | None | 36 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 1 | 3 | ChEMBL | 577 | 8 | 3 | 7 | 3.2 | CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@@H]1CC[C@](CC1)(O)c1ccc2c(c1)OCO2 | 10.1016/j.bmcl.2010.10.020 | |||
777 | 2022 | None | 36 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 1 | 3 | ChEMBL | 577 | 8 | 3 | 7 | 3.2 | CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@@H]1CC[C@](CC1)(O)c1ccc2c(c1)OCO2 | 10.1016/j.bmcl.2010.10.020 | |||
CHEMBL1289316 | 2022 | None | 36 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 1 | 3 | ChEMBL | 577 | 8 | 3 | 7 | 3.2 | CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@@H]1CC[C@](CC1)(O)c1ccc2c(c1)OCO2 | 10.1016/j.bmcl.2010.10.020 | |||
CHEMBL2426341 | 2022 | None | 36 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 1 | 3 | ChEMBL | 577 | 8 | 3 | 7 | 3.2 | CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@@H]1CC[C@](CC1)(O)c1ccc2c(c1)OCO2 | 10.1016/j.bmcl.2010.10.020 | |||
CHEMBL5268600 | 2022 | None | 36 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 1 | 3 | ChEMBL | 577 | 8 | 3 | 7 | 3.2 | CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@@H]1CC[C@](CC1)(O)c1ccc2c(c1)OCO2 | 10.1016/j.bmcl.2010.10.020 | |||
44425647 | 86135 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 5 | 2 | ChEMBL | 542 | 6 | 1 | 2 | 7.4 | CC(C)C[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL231039 | 86135 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 5 | 2 | ChEMBL | 542 | 6 | 1 | 2 | 7.4 | CC(C)C[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
57395218 | 71034 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 490 | 6 | 3 | 5 | 2.9 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN([C@H]2CC[C@@](O)(c3cccnc3)CC2)C1 | 10.1021/ml200030q | |||
CHEMBL1951769 | 71034 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 490 | 6 | 3 | 5 | 2.9 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN([C@H]2CC[C@@](O)(c3cccnc3)CC2)C1 | 10.1021/ml200030q | |||
11192346 | 2024 | None | 45 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 1 | 3 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(N1CC[C@@H](C1)NC1CCC(CC1)(O)c1ccc(cn1)c1ncccn1)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200199c | |||
9032 | 2024 | None | 45 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 1 | 3 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(N1CC[C@@H](C1)NC1CCC(CC1)(O)c1ccc(cn1)c1ncccn1)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200199c | |||
CHEMBL2029422 | 2024 | None | 45 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 1 | 3 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(N1CC[C@@H](C1)NC1CCC(CC1)(O)c1ccc(cn1)c1ncccn1)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200199c | |||
50992246 | 58488 | None | 2 | Human | Functional | pIC50 | = | 8.4 | 8.4 | -1 | 5 | ChEMBL | 498 | 6 | 1 | 6 | 3.3 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1683074 | 58488 | None | 2 | Human | Functional | pIC50 | = | 8.4 | 8.4 | -1 | 5 | ChEMBL | 498 | 6 | 1 | 6 | 3.3 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
508869 | 95493 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 446 | 7 | 3 | 4 | 3.1 | C=Cc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL257066 | 95493 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 446 | 7 | 3 | 4 | 3.1 | C=Cc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
44425647 | 86135 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 5 | 2 | ChEMBL | 542 | 6 | 1 | 2 | 7.4 | CC(C)C[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL231039 | 86135 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 5 | 2 | ChEMBL | 542 | 6 | 1 | 2 | 7.4 | CC(C)C[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
44425643 | 86076 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 14 | 2 | ChEMBL | 500 | 4 | 1 | 2 | 6.3 | C[C@H]1CN([C@@H]2CC[C@](C)(C(=O)NCc3cc(F)cc(C(F)(F)F)c3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL230722 | 86076 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 14 | 2 | ChEMBL | 500 | 4 | 1 | 2 | 6.3 | C[C@H]1CN([C@@H]2CC[C@](C)(C(=O)NCc3cc(F)cc(C(F)(F)F)c3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
46241717 | 83600 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 520 | 8 | 3 | 6 | 2.9 | CCOc1ccc([C@]2(O)CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cn1 | 10.1021/ml300260s | |||
CHEMBL2204249 | 83600 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 520 | 8 | 3 | 6 | 2.9 | CCOc1ccc([C@]2(O)CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cn1 | 10.1021/ml300260s | |||
46208367 | 83614 | None | 16 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 482 | 6 | 3 | 6 | 2.5 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@@](O)(c3cncs3)CC2)C1 | 10.1021/ml300260s | |||
CHEMBL2204263 | 83614 | None | 16 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 482 | 6 | 3 | 6 | 2.5 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@@](O)(c3cncs3)CC2)C1 | 10.1021/ml300260s | |||
24801522 | 161231 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 573 | 6 | 3 | 3 | 3.9 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@H]1CCCC[C@H]1NC(=O)c1ccc(I)cc1 | 10.1021/jm701488f | |||
CHEMBL411726 | 161231 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 573 | 6 | 3 | 3 | 3.9 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@H]1CCCC[C@H]1NC(=O)c1ccc(I)cc1 | 10.1021/jm701488f | |||
56657929 | 65813 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 485 | 6 | 2 | 5 | 4.5 | Cn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](c4ccccc4)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834785 | 65813 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 485 | 6 | 2 | 5 | 4.5 | Cn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](c4ccccc4)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
46842383 | 8347 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 530 | 8 | 2 | 4 | 3.6 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCC2CCN(C(=O)c3ccccc3)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1092929 | 8347 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 530 | 8 | 2 | 4 | 3.6 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCC2CCN(C(=O)c3ccccc3)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
44425308 | 153795 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 627 | 9 | 3 | 5 | 6.6 | CNC(=O)Nc1nc([C@@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL398150 | 153795 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 627 | 9 | 3 | 5 | 6.6 | CNC(=O)Nc1nc([C@@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
10111333 | 175571 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 19 | 2 | ChEMBL | 395 | 3 | 1 | 3 | 4.3 | CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
CHEMBL4577133 | 175571 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 19 | 2 | ChEMBL | 395 | 3 | 1 | 3 | 4.3 | CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
44425308 | 153795 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 627 | 9 | 3 | 5 | 6.6 | CNC(=O)Nc1nc([C@@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL398150 | 153795 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 627 | 9 | 3 | 5 | 6.6 | CNC(=O)Nc1nc([C@@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
54585107 | 62581 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 498 | 6 | 1 | 6 | 3.3 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3ccnc(C(F)(F)F)c3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782567 | 62581 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 498 | 6 | 1 | 6 | 3.3 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3ccnc(C(F)(F)F)c3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
44353447 | 3775 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 433 | 6 | 2 | 3 | 3.4 | O=C(N[C@@H]1CCN(C1)Cc1ccc(cc1C)C)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1016/j.bmcl.2010.02.072 | |||
785 | 3775 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 433 | 6 | 2 | 3 | 3.4 | O=C(N[C@@H]1CCN(C1)Cc1ccc(cc1C)C)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL337246 | 3775 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 433 | 6 | 2 | 3 | 3.4 | O=C(N[C@@H]1CCN(C1)Cc1ccc(cc1C)C)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1016/j.bmcl.2010.02.072 | |||
137654404 | 158661 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 551 | 8 | 1 | 4 | 6.4 | Cc1ccc(-c2ccc3c(c2)C(=O)N(CC(C)C)CC(C(=O)Nc2ccc(CN(C)C4CCOCC4)cc2)=C3)cc1 | 10.1016/j.ejmech.2017.04.046 | |||
CHEMBL4091736 | 158661 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 551 | 8 | 1 | 4 | 6.4 | Cc1ccc(-c2ccc3c(c2)C(=O)N(CC(C)C)CC(C(=O)Nc2ccc(CN(C)C4CCOCC4)cc2)=C3)cc1 | 10.1016/j.ejmech.2017.04.046 | |||
44421922 | 144638 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 321 | 4 | 3 | 4 | 3.2 | Nc1cccc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)c1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL390736 | 144638 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 321 | 4 | 3 | 4 | 3.2 | Nc1cccc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)c1 | 10.1016/j.bmc.2006.09.052 | |||
9836178 | 85111 | None | 2 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 306 | 4 | 2 | 3 | 3.6 | c1ccc(CN2CCC(Nc3ccc4[nH]ncc4c3)CC2)cc1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL224500 | 85111 | None | 2 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 306 | 4 | 2 | 3 | 3.6 | c1ccc(CN2CCC(Nc3ccc4[nH]ncc4c3)CC2)cc1 | 10.1016/j.bmc.2006.09.052 | |||
10245340 | 169040 | None | 4 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 318 | 4 | 2 | 4 | 3.5 | Nc1cccc(CN2CC[C@H](Nc3cccc4cnccc34)C2)c1 | 10.1016/j.bmc.2006.10.028 | |||
CHEMBL438783 | 169040 | None | 4 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 318 | 4 | 2 | 4 | 3.5 | Nc1cccc(CN2CC[C@H](Nc3cccc4cnccc34)C2)c1 | 10.1016/j.bmc.2006.10.028 | |||
67011331 | 74571 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 557 | 7 | 3 | 7 | 3.5 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncco4)cn3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
CHEMBL2029424 | 74571 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 557 | 7 | 3 | 7 | 3.5 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncco4)cn3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
57656657 | 75235 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 444 | 4 | 1 | 3 | 4.4 | O=C(Nc1ccc(C(F)(F)F)c(Cl)c1)N1CCN(C[C@@H]2CCCN(C3CC3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036760 | 75235 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 444 | 4 | 1 | 3 | 4.4 | O=C(Nc1ccc(C(F)(F)F)c(Cl)c1)N1CCN(C[C@@H]2CCCN(C3CC3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
56671792 | 65815 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 472 | 6 | 3 | 5 | 3.9 | O=C(CNc1n[nH]c2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](c3cccnc3)CC2)C1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834787 | 65815 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 472 | 6 | 3 | 5 | 3.9 | O=C(CNc1n[nH]c2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](c3cccnc3)CC2)C1 | 10.1016/j.bmcl.2011.08.074 | |||
162666730 | 182380 | None | 1 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 562 | 3 | ChEMBL | 589 | 9 | 2 | 6 | 6.5 | N#CSCCNC(=O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
CHEMBL4783861 | 182380 | None | 1 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 562 | 3 | ChEMBL | 589 | 9 | 2 | 6 | 6.5 | N#CSCCNC(=O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
122181149 | 121903 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 494 | 7 | 1 | 4 | 4.8 | COc1ccc2c(c1)CCOC21CCN(CCCC(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC1 | 10.1016/j.bmc.2015.02.019 | |||
CHEMBL3589844 | 121903 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 494 | 7 | 1 | 4 | 4.8 | COc1ccc2c(c1)CCOC21CCN(CCCC(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC1 | 10.1016/j.bmc.2015.02.019 | |||
11534473 | 90733 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 117 | 2 | ChEMBL | 594 | 14 | 1 | 5 | 8.0 | CCN(CC)CCCC(NC(=O)CCOc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1)C(C)C | 10.1016/j.bmcl.2006.10.060 | |||
CHEMBL239144 | 90733 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 117 | 2 | ChEMBL | 594 | 14 | 1 | 5 | 8.0 | CCN(CC)CCCC(NC(=O)CCOc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1)C(C)C | 10.1016/j.bmcl.2006.10.060 | |||
10117480 | 73742 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 494 | 11 | 5 | 5 | 3.1 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1N | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018380 | 73742 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 494 | 11 | 5 | 5 | 3.1 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1N | 10.1016/j.bmcl.2012.03.007 | |||
70688149 | 75250 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 413 | 4 | 2 | 4 | 2.8 | CC(C)N1CCN[C@@H](CN2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036777 | 75250 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 413 | 4 | 2 | 4 | 2.8 | CC(C)N1CCN[C@@H](CN2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
44296219 | 101369 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 435 | 4 | 1 | 5 | 5.2 | Cc1ccc2c(c1)C1(CCN(CCc3nc(-c4ccc(F)cc4)oc3C)CC1)OC(=O)N2 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL296609 | 101369 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 435 | 4 | 1 | 5 | 5.2 | Cc1ccc2c(c1)C1(CCN(CCc3nc(-c4ccc(F)cc4)oc3C)CC1)OC(=O)N2 | 10.1016/s0960-894x(00)00347-4 | |||
44442598 | 154476 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 465 | 9 | 5 | 5 | 1.4 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2N)C(N)=O)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL398747 | 154476 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 465 | 9 | 5 | 5 | 1.4 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2N)C(N)=O)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
71452241 | 83601 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 574 | 8 | 3 | 6 | 3.4 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@@](O)(c3ccc(OCC(F)(F)F)nc3)CC2)C1 | 10.1021/ml300260s | |||
CHEMBL2204250 | 83601 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 574 | 8 | 3 | 6 | 3.4 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@@](O)(c3ccc(OCC(F)(F)F)nc3)CC2)C1 | 10.1021/ml300260s | |||
10120067 | 73755 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 550 | 12 | 5 | 5 | 4.7 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(C)(C)C | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018393 | 73755 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 550 | 12 | 5 | 5 | 4.7 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(C)(C)C | 10.1016/j.bmcl.2012.03.007 | |||
70689914 | 74578 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 552 | 6 | 2 | 9 | 3.0 | N#Cc1ccnc(N2CCC(C(=O)N3CC[C@H](N[C@H]4CC[C@@](O)(c5ccc(-c6ncccn6)cn5)CC4)C3)CC2)c1 | 10.1021/ml200199c | |||
CHEMBL2029571 | 74578 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 552 | 6 | 2 | 9 | 3.0 | N#Cc1ccnc(N2CCC(C(=O)N3CC[C@H](N[C@H]4CC[C@@](O)(c5ccc(-c6ncccn6)cn5)CC4)C3)CC2)c1 | 10.1021/ml200199c | |||
70689915 | 74579 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 611 | 6 | 3 | 9 | 3.3 | O=C(N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncccn4)cn3)CC2)C1)C1(O)CCN(c2cc(C(F)(F)F)ccn2)CC1 | 10.1021/ml200199c | |||
CHEMBL2029572 | 74579 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 611 | 6 | 3 | 9 | 3.3 | O=C(N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncccn4)cn3)CC2)C1)C1(O)CCN(c2cc(C(F)(F)F)ccn2)CC1 | 10.1021/ml200199c | |||
162666730 | 182380 | None | 1 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 562 | 3 | ChEMBL | 589 | 9 | 2 | 6 | 6.5 | N#CSCCNC(=O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
CHEMBL4783861 | 182380 | None | 1 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 562 | 3 | ChEMBL | 589 | 9 | 2 | 6 | 6.5 | N#CSCCNC(=O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
56659197 | 65825 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 506 | 6 | 2 | 7 | 4.3 | Cc1ncc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4nn(C)c5ccc(C(F)(F)F)cc45)C3)CC2)s1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834797 | 65825 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 506 | 6 | 2 | 7 | 4.3 | Cc1ncc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4nn(C)c5ccc(C(F)(F)F)cc45)C3)CC2)s1 | 10.1016/j.bmcl.2011.08.074 | |||
22725647 | 173803 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 52 | 2 | ChEMBL | 347 | 3 | 1 | 3 | 4.3 | CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
CHEMBL4535696 | 173803 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 52 | 2 | ChEMBL | 347 | 3 | 1 | 3 | 4.3 | CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
155521447 | 170687 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | 3 | 2 | ChEMBL | 421 | 4 | 1 | 3 | 4.7 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1)C1CC1 | 10.1021/acs.jmedchem.8b00605 | |||
CHEMBL4450561 | 170687 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | 3 | 2 | ChEMBL | 421 | 4 | 1 | 3 | 4.7 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1)C1CC1 | 10.1021/acs.jmedchem.8b00605 | |||
145954949 | 161738 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 539 | 8 | 2 | 6 | 3.9 | CS(=O)(=O)NC1CCN(CCCN2CCCc3c(ccnc3Nc3ccc(Cl)c(Cl)c3)C2=O)CC1 | 10.1016/j.bmc.2018.05.027 | |||
CHEMBL4130191 | 161738 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 539 | 8 | 2 | 6 | 3.9 | CS(=O)(=O)NC1CCN(CCCN2CCCc3c(ccnc3Nc3ccc(Cl)c(Cl)c3)C2=O)CC1 | 10.1016/j.bmc.2018.05.027 | |||
10129343 | 173369 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 642 | 11 | 3 | 6 | 5.2 | CCN(CC)C(=O)Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@H]1CCCC[C@H]1CS(=O)(=O)c1ccc(SC)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL452509 | 173369 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 642 | 11 | 3 | 6 | 5.2 | CCN(CC)C(=O)Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@H]1CCCC[C@H]1CS(=O)(=O)c1ccc(SC)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
56668309 | 65797 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 558 | 6 | 3 | 8 | 3.6 | NC(=O)n1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](c4ccc5c(c4)OCO5)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834718 | 65797 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 558 | 6 | 3 | 8 | 3.6 | NC(=O)n1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](c4ccc5c(c4)OCO5)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
54756038 | 65799 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 468 | 7 | 2 | 7 | 3.2 | CCOC(=O)[C@H]1CC[C@@H](N2CC(NC(=O)CNc3noc4ccc(C(F)(F)F)cc34)C2)CC1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834720 | 65799 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 468 | 7 | 2 | 7 | 3.2 | CCOC(=O)[C@H]1CC[C@@H](N2CC(NC(=O)CNc3noc4ccc(C(F)(F)F)cc34)C2)CC1 | 10.1016/j.bmcl.2011.08.074 | |||
49763571 | 65439 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 459 | 6 | 2 | 3 | 4.0 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3ccccc3)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829609 | 65439 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 459 | 6 | 2 | 3 | 4.0 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3ccccc3)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
46945254 | 65456 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 475 | 6 | 3 | 5 | 2.9 | Nc1cccnc1[C@H]1CC[C@H](N2CC(NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829626 | 65456 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 475 | 6 | 3 | 5 | 2.9 | Nc1cccnc1[C@H]1CC[C@H](N2CC(NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2011.06.080 | |||
57344305 | 68961 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 539 | 7 | 3 | 4 | 4.4 | NC(=O)C(NC1CCC(c2c[nH]c3cccnc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922797 | 68961 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 539 | 7 | 3 | 4 | 4.4 | NC(=O)C(NC1CCC(c2c[nH]c3cccnc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
44453373 | 97864 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 435 | 7 | 2 | 4 | 2.8 | COc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL271935 | 97864 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 435 | 7 | 2 | 4 | 2.8 | COc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
54755079 | 65762 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 528 | 8 | 4 | 5 | 3.5 | NC(=O)Cc1ccc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4n[nH]c5ccc(C(F)(F)F)cc45)C3)CC2)cc1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834633 | 65762 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 528 | 8 | 4 | 5 | 3.5 | NC(=O)Cc1ccc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4n[nH]c5ccc(C(F)(F)F)cc45)C3)CC2)cc1 | 10.1016/j.bmcl.2011.08.074 | |||
3547 | 141460 | None | 43 | Human | Functional | pIC50 | = | 4.5 | 4.5 | -8 | 8 | ChEMBL | 291 | 2 | 1 | 4 | 1.2 | O=S(=O)(c1cccc2cnccc12)N1CCCNCC1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL38380 | 141460 | None | 43 | Human | Functional | pIC50 | = | 4.5 | 4.5 | -8 | 8 | ChEMBL | 291 | 2 | 1 | 4 | 1.2 | O=S(=O)(c1cccc2cnccc12)N1CCCNCC1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL541388 | 141460 | None | 43 | Human | Functional | pIC50 | = | 4.5 | 4.5 | -8 | 8 | ChEMBL | 291 | 2 | 1 | 4 | 1.2 | O=S(=O)(c1cccc2cnccc12)N1CCCNCC1 | 10.1016/j.bmc.2006.09.052 | |||
3547 | 141460 | None | 43 | Human | Functional | pIC50 | = | 4.5 | 4.5 | -8 | 8 | ChEMBL | 291 | 2 | 1 | 4 | 1.2 | O=S(=O)(c1cccc2cnccc12)N1CCCNCC1 | 10.1016/j.bmc.2006.10.028 | |||
CHEMBL38380 | 141460 | None | 43 | Human | Functional | pIC50 | = | 4.5 | 4.5 | -8 | 8 | ChEMBL | 291 | 2 | 1 | 4 | 1.2 | O=S(=O)(c1cccc2cnccc12)N1CCCNCC1 | 10.1016/j.bmc.2006.10.028 | |||
CHEMBL541388 | 141460 | None | 43 | Human | Functional | pIC50 | = | 4.5 | 4.5 | -8 | 8 | ChEMBL | 291 | 2 | 1 | 4 | 1.2 | O=S(=O)(c1cccc2cnccc12)N1CCCNCC1 | 10.1016/j.bmc.2006.10.028 | |||
122181236 | 121917 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | 13 | 2 | ChEMBL | 588 | 8 | 1 | 4 | 6.3 | COc1ccc2c(c1)CCOC21CCN(CCC(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)c2ccc(F)cc2)CC1 | 10.1016/j.bmc.2015.02.019 | |||
CHEMBL3589950 | 121917 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | 13 | 2 | ChEMBL | 588 | 8 | 1 | 4 | 6.3 | COc1ccc2c(c1)CCOC21CCN(CCC(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)c2ccc(F)cc2)CC1 | 10.1016/j.bmc.2015.02.019 | |||
11319072 | 74568 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4cncnc4)cn3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
CHEMBL2029420 | 74568 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4cncnc4)cn3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
57344296 | 68973 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 502 | 7 | 3 | 3 | 4.7 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922813 | 68973 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 502 | 7 | 3 | 3 | 4.7 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
23630215 | 62564 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 508 | 5 | 1 | 5 | 4.3 | CC(C)[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)CC[C@@H](NC2C3CCCC2COC3)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782376 | 62564 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 508 | 5 | 1 | 5 | 4.3 | CC(C)[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)CC[C@@H](NC2C3CCCC2COC3)C1 | 10.1016/j.bmcl.2011.01.034 | |||
44453134 | 98117 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 455 | 7 | 2 | 4 | 3.4 | O=C(CNC(=O)c1cccc(OC(F)(F)F)c1)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL273195 | 98117 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 455 | 7 | 2 | 4 | 3.4 | O=C(CNC(=O)c1cccc(OC(F)(F)F)c1)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
67220645 | 75256 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 399 | 2 | 2 | 4 | 1.6 | CN1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036783 | 75256 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 399 | 2 | 2 | 4 | 1.6 | CN1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
44453298 | 155329 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 421 | 6 | 3 | 4 | 2.5 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccc(O)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL402723 | 155329 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 421 | 6 | 3 | 4 | 2.5 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccc(O)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
44442599 | 93702 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | 31 | 2 | ChEMBL | 585 | 9 | 5 | 5 | 3.3 | Cc1cc(Br)ccc1CNC[C@H](NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1N)C(=O)NC(C)(C)C | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL246804 | 93702 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | 31 | 2 | ChEMBL | 585 | 9 | 5 | 5 | 3.3 | Cc1cc(Br)ccc1CNC[C@H](NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1N)C(=O)NC(C)(C)C | 10.1016/j.bmcl.2007.07.028 | |||
11353843 | 74573 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 594 | 6 | 2 | 7 | 4.8 | O=C(C1CCN(c2cccc(C(F)(F)F)c2)CC1)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncccn4)cn3)CC2)C1 | 10.1021/ml200199c | |||
CHEMBL2029566 | 74573 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 594 | 6 | 2 | 7 | 4.8 | O=C(C1CCN(c2cccc(C(F)(F)F)c2)CC1)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncccn4)cn3)CC2)C1 | 10.1021/ml200199c | |||
56683121 | 65832 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 479 | 6 | 2 | 7 | 4.2 | O=C(CNc1noc2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](c3cncs3)CC2)C1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834853 | 65832 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 479 | 6 | 2 | 7 | 4.2 | O=C(CNc1noc2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](c3cncs3)CC2)C1 | 10.1016/j.bmcl.2011.08.074 | |||
10196988 | 169568 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 628 | 10 | 4 | 6 | 4.8 | CSc1ccc(S(=O)(=O)C[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL442929 | 169568 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 628 | 10 | 4 | 6 | 4.8 | CSc1ccc(S(=O)(=O)C[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
57401954 | 68981 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 520 | 7 | 3 | 3 | 4.9 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2ccc(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922822 | 68981 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 520 | 7 | 3 | 3 | 4.9 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2ccc(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
57656854 | 75254 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 425 | 3 | 2 | 4 | 2.1 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(C(=O)[C@H]2CN(C3CC3)CCN2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036781 | 75254 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 425 | 3 | 2 | 4 | 2.1 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(C(=O)[C@H]2CN(C3CC3)CCN2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
22143255 | 187964 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 523 | 7 | 4 | 6 | 2.4 | CSc1ccc(C(=O)NC2CCN(C)CC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL496343 | 187964 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 523 | 7 | 4 | 6 | 2.4 | CSc1ccc(C(=O)NC2CCN(C)CC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
10323427 | 79791 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 493 | 8 | 2 | 4 | 5.2 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](NCCN1CCCCC1)c1ccsc1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL211775 | 79791 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 493 | 8 | 2 | 4 | 5.2 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](NCCN1CCCCC1)c1ccsc1 | 10.1016/j.bmcl.2008.01.023 | |||
145953765 | 161619 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 537 | 8 | 1 | 7 | 4.2 | CN(C1CCN(CCCn2ccc3c(Nc4ccc(Cl)c(Cl)c4)nccc3c2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
CHEMBL4128372 | 161619 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 537 | 8 | 1 | 7 | 4.2 | CN(C1CCN(CCCn2ccc3c(Nc4ccc(Cl)c(Cl)c4)nccc3c2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
44442587 | 93862 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 611 | 12 | 5 | 5 | 4.9 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NCc2ccccc2)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL247608 | 93862 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 611 | 12 | 5 | 5 | 4.9 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NCc2ccccc2)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
10323427 | 79791 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 493 | 8 | 2 | 4 | 5.2 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](NCCN1CCCCC1)c1ccsc1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL211775 | 79791 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 493 | 8 | 2 | 4 | 5.2 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](NCCN1CCCCC1)c1ccsc1 | 10.1016/j.bmcl.2008.01.023 | |||
10129343 | 173369 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 642 | 11 | 3 | 6 | 5.2 | CCN(CC)C(=O)Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@H]1CCCC[C@H]1CS(=O)(=O)c1ccc(SC)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL452509 | 173369 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 642 | 11 | 3 | 6 | 5.2 | CCN(CC)C(=O)Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@H]1CCCC[C@H]1CS(=O)(=O)c1ccc(SC)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
145962575 | 161562 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 567 | 9 | 1 | 6 | 4.7 | CCS(=O)(=O)N(C)C1CCN(CCCN2CCCc3c(ccnc3Nc3ccc(Cl)c(Cl)c3)C2=O)CC1 | 10.1016/j.bmc.2018.05.027 | |||
CHEMBL4127580 | 161562 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 567 | 9 | 1 | 6 | 4.7 | CCS(=O)(=O)N(C)C1CCN(CCCN2CCCc3c(ccnc3Nc3ccc(Cl)c(Cl)c3)C2=O)CC1 | 10.1016/j.bmc.2018.05.027 | |||
10268598 | 58892 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 334 | 2 | 3 | 5 | 2.7 | O=C(NC(=O)c1ccc2c(c1)OCO2)Nc1ccc(O)c(Cl)c1 | 10.1021/jm1012903 | |||
CHEMBL1688877 | 58892 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 334 | 2 | 3 | 5 | 2.7 | O=C(NC(=O)c1ccc2c(c1)OCO2)Nc1ccc(O)c(Cl)c1 | 10.1021/jm1012903 | |||
10436083 | 79908 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 501 | 8 | 2 | 3 | 5.5 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](NCCN1CCCCCC1)c1ccccc1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL212306 | 79908 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 501 | 8 | 2 | 3 | 5.5 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](NCCN1CCCCCC1)c1ccccc1 | 10.1016/j.bmcl.2008.01.023 | |||
44415880 | 169442 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 550 | 7 | 1 | 2 | 7.1 | C[C@H]1CN(CC[C@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CC2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2006.07.011 | |||
CHEMBL441856 | 169442 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 550 | 7 | 1 | 2 | 7.1 | C[C@H]1CN(CC[C@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CC2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2006.07.011 | |||
46241010 | 83617 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 540 | 8 | 3 | 7 | 3.3 | CC(C)Oc1ncc([C@]2(O)CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)s1 | 10.1021/ml300260s | |||
CHEMBL2204266 | 83617 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 540 | 8 | 3 | 7 | 3.3 | CC(C)Oc1ncc([C@]2(O)CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)s1 | 10.1021/ml300260s | |||
56643545 | 68982 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 520 | 7 | 3 | 3 | 4.9 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)cc(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922823 | 68982 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 520 | 7 | 3 | 3 | 4.9 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)cc(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
10281316 | 73748 | None | 0 | Mouse | Functional | pIC50 | = | 8.4 | 8.4 | 2 | 3 | ChEMBL | 565 | 13 | 6 | 5 | 3.6 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)NCC | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018386 | 73748 | None | 0 | Mouse | Functional | pIC50 | = | 8.4 | 8.4 | 2 | 3 | ChEMBL | 565 | 13 | 6 | 5 | 3.6 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)NCC | 10.1016/j.bmcl.2012.03.007 | |||
25154827 | 174688 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 494 | 6 | 2 | 4 | 4.3 | O=C(/C=C/c1cc(F)cc(F)c1)N1CCC([C@@H](CO)N2CCC(c3c[nH]c4ncccc34)CC2)CC1 | 10.1016/j.bmcl.2008.10.061 | |||
CHEMBL455683 | 174688 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 494 | 6 | 2 | 4 | 4.3 | O=C(/C=C/c1cc(F)cc(F)c1)N1CCC([C@@H](CO)N2CCC(c3c[nH]c4ncccc34)CC2)CC1 | 10.1016/j.bmcl.2008.10.061 | |||
56657930 | 65814 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 528 | 7 | 2 | 6 | 4.6 | CN(C)c1cccc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4nn(C)c5ccc(C(F)(F)F)cc45)C3)CC2)c1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834786 | 65814 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 528 | 7 | 2 | 6 | 4.6 | CN(C)c1cccc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4nn(C)c5ccc(C(F)(F)F)cc45)C3)CC2)c1 | 10.1016/j.bmcl.2011.08.074 | |||
44425643 | 86076 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 14 | 2 | ChEMBL | 500 | 4 | 1 | 2 | 6.3 | C[C@H]1CN([C@@H]2CC[C@](C)(C(=O)NCc3cc(F)cc(C(F)(F)F)c3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL230722 | 86076 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 14 | 2 | ChEMBL | 500 | 4 | 1 | 2 | 6.3 | C[C@H]1CN([C@@H]2CC[C@](C)(C(=O)NCc3cc(F)cc(C(F)(F)F)c3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
10120907 | 73750 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 577 | 12 | 5 | 5 | 3.7 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)N1CCC1 | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018388 | 73750 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 577 | 12 | 5 | 5 | 3.7 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)N1CCC1 | 10.1016/j.bmcl.2012.03.007 | |||
11227168 | 74576 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 596 | 6 | 2 | 9 | 3.6 | O=C(C1CCN(c2nccc(C(F)(F)F)n2)CC1)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncccn4)cn3)CC2)C1 | 10.1021/ml200199c | |||
CHEMBL2029569 | 74576 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 596 | 6 | 2 | 9 | 3.6 | O=C(C1CCN(c2nccc(C(F)(F)F)n2)CC1)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncccn4)cn3)CC2)C1 | 10.1021/ml200199c | |||
11527661 | 2021 | None | 28 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 520 | 7 | 3 | 6 | 2.9 | COc1ccc(cn1)C1(O)CCC(CC1)N1CC[C@H](C1)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200030q | |||
9045 | 2021 | None | 28 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 520 | 7 | 3 | 6 | 2.9 | COc1ccc(cn1)C1(O)CCC(CC1)N1CC[C@H](C1)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200030q | |||
CHEMBL1963131 | 2021 | None | 28 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 520 | 7 | 3 | 6 | 2.9 | COc1ccc(cn1)C1(O)CCC(CC1)N1CC[C@H](C1)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200030q | |||
11527661 | 2021 | None | 28 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 520 | 7 | 3 | 6 | 2.9 | COc1ccc(cn1)C1(O)CCC(CC1)N1CC[C@H](C1)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200199c | |||
9045 | 2021 | None | 28 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 520 | 7 | 3 | 6 | 2.9 | COc1ccc(cn1)C1(O)CCC(CC1)N1CC[C@H](C1)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200199c | |||
CHEMBL1963131 | 2021 | None | 28 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 520 | 7 | 3 | 6 | 2.9 | COc1ccc(cn1)C1(O)CCC(CC1)N1CC[C@H](C1)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200199c | |||
22143346 | 172754 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 634 | 11 | 4 | 6 | 4.5 | CCCN1CCC(NCc2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N2CCCC2)C1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL449672 | 172754 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 634 | 11 | 4 | 6 | 4.5 | CCCN1CCC(NCc2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N2CCCC2)C1 | 10.1016/j.bmcl.2008.07.123 | |||
11753466 | 77669 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 575 | 8 | 2 | 6 | 4.5 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)Cc2nc3cccc(C(F)(F)F)c3[nH]2)[C@H](CS(=O)(=O)c2ccc(C#N)cc2)C1 | 10.1016/j.bmcl.2012.08.002 | |||
CHEMBL2088380 | 77669 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 575 | 8 | 2 | 6 | 4.5 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)Cc2nc3cccc(C(F)(F)F)c3[nH]2)[C@H](CS(=O)(=O)c2ccc(C#N)cc2)C1 | 10.1016/j.bmcl.2012.08.002 | |||
51039119 | 176321 | None | 34 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -1 | 3 | ChEMBL | 484 | 5 | 3 | 8 | 2.2 | CC(=O)N[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1N1CC[C@H](Nc2ncnc3cc(C(C)(C)C)nn23)C1=O | 10.1021/acsmedchemlett.1c00373 | |||
CHEMBL4594419 | 176321 | None | 34 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -1 | 3 | ChEMBL | 484 | 5 | 3 | 8 | 2.2 | CC(=O)N[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1N1CC[C@H](Nc2ncnc3cc(C(C)(C)C)nn23)C1=O | 10.1021/acsmedchemlett.1c00373 | |||
24801526 | 97669 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 541 | 7 | 5 | 6 | 1.5 | Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@H]1CCCC[C@H]1NC(=O)c1ccc(S(N)(=O)=O)cc1 | 10.1021/jm701488f | |||
CHEMBL270959 | 97669 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 541 | 7 | 5 | 6 | 1.5 | Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@H]1CCCC[C@H]1NC(=O)c1ccc(S(N)(=O)=O)cc1 | 10.1021/jm701488f | |||
11330837 | 74577 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 596 | 6 | 2 | 9 | 3.6 | O=C(C1CCN(c2cc(C(F)(F)F)ncn2)CC1)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncccn4)cn3)CC2)C1 | 10.1021/ml200199c | |||
CHEMBL2029570 | 74577 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 596 | 6 | 2 | 9 | 3.6 | O=C(C1CCN(c2cc(C(F)(F)F)ncn2)CC1)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncccn4)cn3)CC2)C1 | 10.1021/ml200199c | |||
56671925 | 65770 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 481 | 7 | 2 | 7 | 2.9 | CCOC(=O)[C@H]1CC[C@@H](N2CC(NC(=O)CNc3nn(C)c4ccc(C(F)(F)F)cc34)C2)CC1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834640 | 65770 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 481 | 7 | 2 | 7 | 2.9 | CCOC(=O)[C@H]1CC[C@@H](N2CC(NC(=O)CNc3nn(C)c4ccc(C(F)(F)F)cc34)C2)CC1 | 10.1016/j.bmcl.2011.08.074 | |||
22725647 | 173803 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | 52 | 2 | ChEMBL | 347 | 3 | 1 | 3 | 4.3 | CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
CHEMBL4535696 | 173803 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | 52 | 2 | ChEMBL | 347 | 3 | 1 | 3 | 4.3 | CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
54582215 | 62580 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 498 | 6 | 1 | 6 | 3.3 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cncc(C(F)(F)F)c3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782566 | 62580 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 498 | 6 | 1 | 6 | 3.3 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cncc(C(F)(F)F)c3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
10436083 | 79908 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 501 | 8 | 2 | 3 | 5.5 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](NCCN1CCCCCC1)c1ccccc1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL212306 | 79908 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 501 | 8 | 2 | 3 | 5.5 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](NCCN1CCCCCC1)c1ccccc1 | 10.1016/j.bmcl.2008.01.023 | |||
9858433 | 85112 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 324 | 4 | 2 | 3 | 3.8 | Fc1ccc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)cc1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL224509 | 85112 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 324 | 4 | 2 | 3 | 3.8 | Fc1ccc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)cc1 | 10.1016/j.bmc.2006.09.052 | |||
127025091 | 138297 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 424 | 3 | 2 | 7 | 1.2 | COc1sc(NC(=O)N2CCN(C(=O)[C@H]3CN(C(C)(C)C)CCN3)CC2)nc1C | 10.1039/C5MD00362H | |||
CHEMBL3769934 | 138297 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 424 | 3 | 2 | 7 | 1.2 | COc1sc(NC(=O)N2CCN(C(=O)[C@H]3CN(C(C)(C)C)CCN3)CC2)nc1C | 10.1039/C5MD00362H | |||
22143305 | 183718 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 506 | 9 | 3 | 5 | 3.2 | COc1ccc(CNC2CC(N(C)C)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
CHEMBL480228 | 183718 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 506 | 9 | 3 | 5 | 3.2 | COc1ccc(CNC2CC(N(C)C)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
44425306 | 142456 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 612 | 9 | 2 | 5 | 6.8 | CC(=O)Nc1nc([C@@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL388949 | 142456 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 612 | 9 | 2 | 5 | 6.8 | CC(=O)Nc1nc([C@@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
44453592 | 160149 | None | 24 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 405 | 6 | 2 | 3 | 2.8 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccccc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL410829 | 160149 | None | 24 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 405 | 6 | 2 | 3 | 2.8 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccccc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
44453565 | 169110 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 439 | 6 | 2 | 3 | 3.5 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccccc2Cl)C1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL439252 | 169110 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 439 | 6 | 2 | 3 | 3.5 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccccc2Cl)C1 | 10.1016/j.bmcl.2008.02.015 | |||
49764447 | 65443 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 475 | 6 | 3 | 4 | 3.7 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3ccc(O)cc3)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829613 | 65443 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 475 | 6 | 3 | 4 | 3.7 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3ccc(O)cc3)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
24801525 | 97662 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 526 | 7 | 4 | 5 | 1.9 | NS(=O)(=O)c1ccc(C(=O)N[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1021/jm701488f | |||
CHEMBL270906 | 97662 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 526 | 7 | 4 | 5 | 1.9 | NS(=O)(=O)c1ccc(C(=O)N[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1021/jm701488f | |||
11598084 | 75230 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 474 | 6 | 1 | 3 | 5.1 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(C[C@@H]2CCCN(CCc3ccccc3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036755 | 75230 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 474 | 6 | 1 | 3 | 5.1 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(C[C@@H]2CCCN(CCc3ccccc3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
57656641 | 75248 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 414 | 4 | 1 | 4 | 3.3 | CC(C)N1CCO[C@@H](CN2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036775 | 75248 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 414 | 4 | 1 | 4 | 3.3 | CC(C)N1CCO[C@@H](CN2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
44425306 | 142456 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 612 | 9 | 2 | 5 | 6.8 | CC(=O)Nc1nc([C@@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL388949 | 142456 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 612 | 9 | 2 | 5 | 6.8 | CC(=O)Nc1nc([C@@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2008.01.023 | |||
57656749 | 75236 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 444 | 4 | 1 | 3 | 4.4 | O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)N1CCN(C[C@@H]2CCCN(C3CC3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036761 | 75236 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 444 | 4 | 1 | 3 | 4.4 | O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)N1CCN(C[C@@H]2CCCN(C3CC3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
44413147 | 139800 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 453 | 8 | 2 | 4 | 4.3 | CN(C)CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccsc1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL379818 | 139800 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 453 | 8 | 2 | 4 | 4.3 | CN(C)CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccsc1 | 10.1016/j.bmcl.2008.01.023 | |||
44413147 | 139800 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 453 | 8 | 2 | 4 | 4.3 | CN(C)CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccsc1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL379818 | 139800 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 453 | 8 | 2 | 4 | 4.3 | CN(C)CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccsc1 | 10.1016/j.bmcl.2008.01.023 | |||
46241718 | 83604 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 546 | 8 | 3 | 6 | 3.4 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@@](O)(c3ccc(OC4CCC4)nc3)CC2)C1 | 10.1021/ml300260s | |||
CHEMBL2204253 | 83604 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 546 | 8 | 3 | 6 | 3.4 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@@](O)(c3ccc(OC4CCC4)nc3)CC2)C1 | 10.1021/ml300260s | |||
44453471 | 97923 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 470 | 7 | 3 | 5 | 2.9 | Nc1ccc(OC(F)(F)F)cc1C(=O)NCC(=O)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL272283 | 97923 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 470 | 7 | 3 | 5 | 2.9 | Nc1ccc(OC(F)(F)F)cc1C(=O)NCC(=O)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
44453562 | 155744 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 431 | 7 | 3 | 6 | 2.0 | Nc1ccc([N+](=O)[O-])cc1C(=O)NCC(=O)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL404837 | 155744 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 431 | 7 | 3 | 6 | 2.0 | Nc1ccc([N+](=O)[O-])cc1C(=O)NCC(=O)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
10312346 | 188569 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 614 | 9 | 3 | 6 | 4.4 | CSc1ccc(S(=O)(=O)C[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N(C)C)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL502795 | 188569 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 614 | 9 | 3 | 6 | 4.4 | CSc1ccc(S(=O)(=O)C[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N(C)C)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
54581190 | 62582 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 499 | 6 | 1 | 7 | 2.7 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cncc(C(F)(F)F)n3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782568 | 62582 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 499 | 6 | 1 | 7 | 2.7 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cncc(C(F)(F)F)n3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
70696470 | 75244 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 367 | 4 | 1 | 4 | 2.6 | N#Cc1ccc(NC(=O)N2CCN(C[C@@H]3CCCN(C4CC4)C3)CC2)cc1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036769 | 75244 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 367 | 4 | 1 | 4 | 2.6 | N#Cc1ccc(NC(=O)N2CCN(C[C@@H]3CCCN(C4CC4)C3)CC2)cc1 | 10.1016/j.bmcl.2012.04.118 | |||
46241608 | 83602 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 534 | 8 | 3 | 6 | 3.2 | CC(C)Oc1ccc([C@]2(O)CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cn1 | 10.1021/ml300260s | |||
CHEMBL2204251 | 83602 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 534 | 8 | 3 | 6 | 3.2 | CC(C)Oc1ccc([C@]2(O)CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cn1 | 10.1021/ml300260s | |||
11756884 | 19096 | None | 0 | Mouse | Functional | pIC50 | = | 6.4 | 6.4 | -25 | 2 | ChEMBL | 533 | 8 | 3 | 5 | 3.5 | CCO[C@H]1CN([C@H]2CC[C@@](O)(c3ccccc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.10.020 | |||
CHEMBL1289083 | 19096 | None | 0 | Mouse | Functional | pIC50 | = | 6.4 | 6.4 | -25 | 2 | ChEMBL | 533 | 8 | 3 | 5 | 3.5 | CCO[C@H]1CN([C@H]2CC[C@@](O)(c3ccccc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.10.020 | |||
508729 | 95588 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 416 | 7 | 2 | 5 | 2.4 | O=C(CNC(=O)c1cccc([N+](=O)[O-])c1)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL257510 | 95588 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 416 | 7 | 2 | 5 | 2.4 | O=C(CNC(=O)c1cccc([N+](=O)[O-])c1)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
145963612 | 161533 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 448 | 6 | 1 | 5 | 4.2 | O=C1c2ccnc(Nc3ccc(Cl)c(Cl)c3)c2CCCN1CCCN1CCOCC1 | 10.1016/j.bmc.2018.05.027 | |||
CHEMBL4127249 | 161533 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 448 | 6 | 1 | 5 | 4.2 | O=C1c2ccnc(Nc3ccc(Cl)c(Cl)c3)c2CCCN1CCCN1CCOCC1 | 10.1016/j.bmc.2018.05.027 | |||
54582216 | 62585 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 500 | 6 | 1 | 8 | 2.1 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3nncc(C(F)(F)F)n3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782571 | 62585 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 500 | 6 | 1 | 8 | 2.1 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3nncc(C(F)(F)F)n3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
54583186 | 62592 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 496 | 6 | 1 | 5 | 4.3 | CCC1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782578 | 62592 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 496 | 6 | 1 | 5 | 4.3 | CCC1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
122181151 | 121905 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | 7 | 2 | ChEMBL | 622 | 7 | 1 | 3 | 7.6 | CC1Cc2ccccc2C2(CCN(CCC(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccc(F)cc3)CC2)O1 | 10.1016/j.bmc.2015.02.019 | |||
CHEMBL3589846 | 121905 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | 7 | 2 | ChEMBL | 622 | 7 | 1 | 3 | 7.6 | CC1Cc2ccccc2C2(CCN(CCC(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccc(F)cc3)CC2)O1 | 10.1016/j.bmc.2015.02.019 | |||
54754722 | 65773 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 439 | 6 | 3 | 6 | 2.4 | Cn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](CO)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834643 | 65773 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 439 | 6 | 3 | 6 | 2.4 | Cn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](CO)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
44453171 | 95790 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 449 | 6 | 2 | 3 | 3.2 | O=C(CNC(=O)c1cccc(Br)c1)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL258364 | 95790 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 449 | 6 | 2 | 3 | 3.2 | O=C(CNC(=O)c1cccc(Br)c1)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
57344221 | 68979 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 568 | 8 | 3 | 4 | 5.5 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2ccc(OC(F)(F)F)cc2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922819 | 68979 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 568 | 8 | 3 | 4 | 5.5 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2ccc(OC(F)(F)F)cc2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
145955877 | 161498 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 503 | 8 | 1 | 6 | 3.1 | CN(C1CCN(CCCN2CCCc3c(ccnc3Nc3cccc(F)c3)C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
CHEMBL4126634 | 161498 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 503 | 8 | 1 | 6 | 3.1 | CN(C1CCN(CCCN2CCCc3c(ccnc3Nc3cccc(F)c3)C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
22143334 | 187914 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 509 | 8 | 4 | 6 | 2.7 | CSc1ccc(CNC2CCN(C)CC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL495924 | 187914 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 509 | 8 | 4 | 6 | 2.7 | CSc1ccc(CNC2CCN(C)CC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
10209478 | 73747 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 551 | 12 | 6 | 5 | 3.2 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)NC | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018385 | 73747 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 551 | 12 | 6 | 5 | 3.2 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)NC | 10.1016/j.bmcl.2012.03.007 | |||
11591776 | 145574 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 525 | 6 | 2 | 3 | 5.2 | O=C(O)C(C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1)N1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL391459 | 145574 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 525 | 6 | 2 | 3 | 5.2 | O=C(O)C(C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1)N1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
10239991 | 188554 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 585 | 10 | 3 | 6 | 4.3 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](NC(C)C)CC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL502516 | 188554 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 585 | 10 | 3 | 6 | 4.3 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](NC(C)C)CC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
44593555 | 188892 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 2 | 2 | ChEMBL | 642 | 10 | 4 | 6 | 4.9 | CSc1ccc(C(=O)NC2CC(NC(=O)OCc3ccccc3)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
CHEMBL505722 | 188892 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 2 | 2 | ChEMBL | 642 | 10 | 4 | 6 | 4.9 | CSc1ccc(C(=O)NC2CC(NC(=O)OCc3ccccc3)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
44453408 | 95491 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 436 | 6 | 4 | 5 | 2.1 | Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@@H]1CCN(Cc2ccc(O)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL257064 | 95491 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 436 | 6 | 4 | 5 | 2.1 | Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@@H]1CCN(Cc2ccc(O)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
44573608 | 187657 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 522 | 8 | 2 | 3 | 6.3 | CCCC1COCCC1N[C@@H]1CC[C@@](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(C(C)C)C1 | 10.1016/j.bmcl.2008.12.050 | |||
CHEMBL494540 | 187657 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 522 | 8 | 2 | 3 | 6.3 | CCCC1COCCC1N[C@@H]1CC[C@@](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(C(C)C)C1 | 10.1016/j.bmcl.2008.12.050 | |||
10167417 | 73751 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 591 | 12 | 5 | 5 | 4.1 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)N1CCCC1 | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018389 | 73751 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 591 | 12 | 5 | 5 | 4.1 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)N1CCCC1 | 10.1016/j.bmcl.2012.03.007 | |||
44453440 | 97741 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 448 | 7 | 3 | 4 | 3.0 | CCc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL271288 | 97741 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 448 | 7 | 3 | 4 | 3.0 | CCc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
44425293 | 153553 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 636 | 8 | 2 | 5 | 7.0 | CC(=O)Nc1nc([C@H](CCN2CCC3(C=Cc4ccccc43)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
CHEMBL397948 | 153553 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 636 | 8 | 2 | 5 | 7.0 | CC(=O)Nc1nc([C@H](CCN2CCC3(C=Cc4ccccc43)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
22143155 | 188168 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 537 | 10 | 4 | 6 | 3.5 | CCCN1CCC(NCc2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL497788 | 188168 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 537 | 10 | 4 | 6 | 3.5 | CCCN1CCC(NCc2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C1 | 10.1016/j.bmcl.2008.07.123 | |||
11330529 | 74566 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 567 | 7 | 3 | 6 | 3.9 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4cccnc4)cn3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
CHEMBL2029418 | 74566 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 567 | 7 | 3 | 6 | 3.9 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4cccnc4)cn3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
22143146 | 184012 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 490 | 8 | 3 | 4 | 3.5 | Cc1ccc(CNC2CC(N(C)C)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
CHEMBL481202 | 184012 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 490 | 8 | 3 | 4 | 3.5 | Cc1ccc(CNC2CC(N(C)C)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
44453298 | 155329 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 421 | 6 | 3 | 4 | 2.5 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccc(O)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL402723 | 155329 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 421 | 6 | 3 | 4 | 2.5 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccc(O)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
57396999 | 71042 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 504 | 6 | 3 | 5 | 3.2 | Cc1ccc([C@]2(O)CC[C@H](N3CC[C@@H](NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cn1 | 10.1021/ml200030q | |||
CHEMBL1951777 | 71042 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 504 | 6 | 3 | 5 | 3.2 | Cc1ccc([C@]2(O)CC[C@H](N3CC[C@@H](NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cn1 | 10.1021/ml200030q | |||
11192943 | 77653 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 628 | 8 | 2 | 5 | 5.4 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)Cc2nc3cccc(C(F)(F)F)c3[nH]2)[C@H](CS(=O)(=O)c2ccc(Br)cc2)C1 | 10.1016/j.bmcl.2012.08.002 | |||
CHEMBL2088212 | 77653 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 628 | 8 | 2 | 5 | 5.4 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)Cc2nc3cccc(C(F)(F)F)c3[nH]2)[C@H](CS(=O)(=O)c2ccc(Br)cc2)C1 | 10.1016/j.bmcl.2012.08.002 | |||
53322809 | 58474 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 13 | 2 | ChEMBL | 481 | 5 | 1 | 4 | 4.6 | CC(C)[C@]1(C(=O)N2CCN(c3cccc(C(F)(F)F)c3)CC2)CC[C@@H](N[C@@H]2CCOC[C@@H]2C)C1 | 10.1016/j.bmcl.2011.01.015 | |||
CHEMBL1683060 | 58474 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 13 | 2 | ChEMBL | 481 | 5 | 1 | 4 | 4.6 | CC(C)[C@]1(C(=O)N2CCN(c3cccc(C(F)(F)F)c3)CC2)CC[C@@H](N[C@@H]2CCOC[C@@H]2C)C1 | 10.1016/j.bmcl.2011.01.015 | |||
57391765 | 71039 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 491 | 6 | 3 | 6 | 2.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN([C@H]2CC[C@@](O)(c3cccnn3)CC2)C1 | 10.1021/ml200030q | |||
CHEMBL1951774 | 71039 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 491 | 6 | 3 | 6 | 2.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN([C@H]2CC[C@@](O)(c3cccnn3)CC2)C1 | 10.1021/ml200030q | |||
69035439 | 77677 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 576 | 7 | 1 | 5 | 5.2 | CC(C)N(C)[C@@H]1CC[C@H](N2CCC(c3nc4cccc(C(F)(F)F)c4[nH]3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2012.08.002 | |||
CHEMBL2088388 | 77677 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 576 | 7 | 1 | 5 | 5.2 | CC(C)N(C)[C@@H]1CC[C@H](N2CCC(c3nc4cccc(C(F)(F)F)c4[nH]3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2012.08.002 | |||
57656833 | 75255 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 4 | 4 | ChEMBL | 427 | 3 | 2 | 4 | 2.4 | CC(C)N1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036782 | 75255 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 4 | 4 | ChEMBL | 427 | 3 | 2 | 4 | 2.4 | CC(C)N1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
10323427 | 79791 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 493 | 8 | 2 | 4 | 5.2 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](NCCN1CCCCC1)c1ccsc1 | 10.1016/j.bmcl.2006.04.045 | |||
CHEMBL211775 | 79791 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 493 | 8 | 2 | 4 | 5.2 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](NCCN1CCCCC1)c1ccsc1 | 10.1016/j.bmcl.2006.04.045 | |||
57400160 | 68947 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 539 | 7 | 3 | 3 | 5.6 | O=C(O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922783 | 68947 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 539 | 7 | 3 | 3 | 5.6 | O=C(O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
54584109 | 62567 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 509 | 5 | 1 | 6 | 3.7 | CC(C)[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)cnn3)CC2)CC[C@@H](NC2C3CCCC2COC3)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782379 | 62567 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 509 | 5 | 1 | 6 | 3.7 | CC(C)[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)cnn3)CC2)CC[C@@H](NC2C3CCCC2COC3)C1 | 10.1016/j.bmcl.2011.01.034 | |||
44421868 | 85192 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 296 | 4 | 2 | 4 | 3.2 | c1coc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)c1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL225167 | 85192 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 296 | 4 | 2 | 4 | 3.2 | c1coc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)c1 | 10.1016/j.bmc.2006.09.052 | |||
21098480 | 144231 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 326 | 4 | 2 | 3 | 3.9 | Clc1cccc(CN2CCC(Nc3ccc4[nH]ncc4c3)C2)c1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL390389 | 144231 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 326 | 4 | 2 | 3 | 3.9 | Clc1cccc(CN2CCC(Nc3ccc4[nH]ncc4c3)C2)c1 | 10.1016/j.bmc.2006.09.052 | |||
145962604 | 161621 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 541 | 8 | 1 | 6 | 4.3 | CN(C1CCN(CCCN2CCCc3c(ccnc3Nc3ccc(C(C)(C)C)cc3)C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
CHEMBL4128399 | 161621 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 541 | 8 | 1 | 6 | 4.3 | CN(C1CCN(CCCN2CCCc3c(ccnc3Nc3ccc(C(C)(C)C)cc3)C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
11180383 | 77652 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 550 | 8 | 2 | 5 | 4.6 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)Cc2nc3cccc(C(F)(F)F)c3[nH]2)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2012.08.002 | |||
CHEMBL2088211 | 77652 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 550 | 8 | 2 | 5 | 4.6 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)Cc2nc3cccc(C(F)(F)F)c3[nH]2)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2012.08.002 | |||
22143200 | 187871 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 480 | 8 | 4 | 5 | 2.8 | CSc1ccc(CNC2CCNCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL495718 | 187871 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 480 | 8 | 4 | 5 | 2.8 | CSc1ccc(CNC2CCNCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
44442586 | 93864 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 521 | 9 | 5 | 5 | 2.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(N)cc(C(F)(F)F)c2)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL247621 | 93864 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 521 | 9 | 5 | 5 | 2.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(N)cc(C(F)(F)F)c2)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
10164316 | 154882 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 506 | 9 | 4 | 4 | 3.2 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL400196 | 154882 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 506 | 9 | 4 | 4 | 3.2 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
56667036 | 65448 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 460 | 6 | 2 | 4 | 3.4 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3cccnc3)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829618 | 65448 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 460 | 6 | 2 | 4 | 3.4 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3cccnc3)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
56677288 | 65464 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 517 | 6 | 3 | 5 | 3.0 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@](O)(c3ccc4c(c3)OCC4)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829634 | 65464 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 517 | 6 | 3 | 5 | 3.0 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@](O)(c3ccc4c(c3)OCC4)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
11409228 | 74560 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 490 | 6 | 3 | 5 | 2.9 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccccn3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
CHEMBL2029412 | 74560 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 490 | 6 | 3 | 5 | 2.9 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccccn3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
46842084 | 7917 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 544 | 8 | 2 | 4 | 3.9 | Cc1ccccc1C(=O)N1CCC(CCN2CC[C@@H](NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1090206 | 7917 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 544 | 8 | 2 | 4 | 3.9 | Cc1ccccc1C(=O)N1CCC(CCN2CC[C@@H](NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)CC1 | 10.1016/j.bmcl.2010.02.072 | |||
57396722 | 68966 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 536 | 4 | 3 | 3 | 5.0 | O=C1NC2(CCC(c3c[nH]c4ccccc34)CC2)NC1C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922801 | 68966 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 536 | 4 | 3 | 3 | 5.0 | O=C1NC2(CCC(c3c[nH]c4ccccc34)CC2)NC1C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
11721085 | 166955 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 565 | 13 | 2 | 5 | 7.4 | CCN(CC)CCCC(C)NC(=O)CCNc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
CHEMBL428559 | 166955 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 565 | 13 | 2 | 5 | 7.4 | CCN(CC)CCCC(C)NC(=O)CCNc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
44353447 | 3775 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 433 | 6 | 2 | 3 | 3.4 | O=C(N[C@@H]1CCN(C1)Cc1ccc(cc1C)C)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/jm030862l | |||
785 | 3775 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 433 | 6 | 2 | 3 | 3.4 | O=C(N[C@@H]1CCN(C1)Cc1ccc(cc1C)C)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/jm030862l | |||
CHEMBL337246 | 3775 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 433 | 6 | 2 | 3 | 3.4 | O=C(N[C@@H]1CCN(C1)Cc1ccc(cc1C)C)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/jm030862l | |||
46927116 | 65458 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 475 | 6 | 3 | 4 | 3.1 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@](O)(c3ccccc3)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829628 | 65458 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 475 | 6 | 3 | 4 | 3.1 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@](O)(c3ccccc3)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
57656871 | 75253 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 413 | 3 | 2 | 4 | 2.0 | CCN1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036780 | 75253 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 413 | 3 | 2 | 4 | 2.0 | CCN1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
145962608 | 161627 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 486 | 8 | 1 | 7 | 2.4 | CN(C1CCN(CCCN2CCCc3c(ccnc3Nc3ccccn3)C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
CHEMBL4128514 | 161627 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 486 | 8 | 1 | 7 | 2.4 | CN(C1CCN(CCCN2CCCc3c(ccnc3Nc3ccccn3)C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
46241509 | 83595 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 506 | 7 | 3 | 6 | 2.5 | COc1ccc([C@]2(O)CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cn1 | 10.1021/ml300260s | |||
CHEMBL2204244 | 83595 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 506 | 7 | 3 | 6 | 2.5 | COc1ccc([C@]2(O)CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cn1 | 10.1021/ml300260s | |||
44423283 | 85341 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 536 | 4 | 1 | 2 | 6.8 | C[C@H]1CN([C@@H]2CC[C@H](C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC[C@@]12C=Cc1ccccc12 | 10.1021/jm070166b | |||
CHEMBL226065 | 85341 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 536 | 4 | 1 | 2 | 6.8 | C[C@H]1CN([C@@H]2CC[C@H](C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC[C@@]12C=Cc1ccccc12 | 10.1021/jm070166b | |||
44442587 | 93862 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 611 | 12 | 5 | 5 | 4.9 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NCc2ccccc2)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL247608 | 93862 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 611 | 12 | 5 | 5 | 4.9 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NCc2ccccc2)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
46944855 | 65455 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 476 | 6 | 3 | 5 | 3.1 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3ccncc3O)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829625 | 65455 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 476 | 6 | 3 | 5 | 3.1 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3ccncc3O)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
44416273 | 139028 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 496 | 6 | 1 | 2 | 6.2 | O=C(CCCN1CCC2(C=Cc3ccccc32)CC1)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL378449 | 139028 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 496 | 6 | 1 | 2 | 6.2 | O=C(CCCN1CCC2(C=Cc3ccccc32)CC1)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.01.023 | |||
44416273 | 139028 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 496 | 6 | 1 | 2 | 6.2 | O=C(CCCN1CCC2(C=Cc3ccccc32)CC1)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL378449 | 139028 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 496 | 6 | 1 | 2 | 6.2 | O=C(CCCN1CCC2(C=Cc3ccccc32)CC1)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.01.023 | |||
57656938 | 75241 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 410 | 4 | 1 | 3 | 3.7 | O=C(Nc1cccc(C(F)(F)F)c1)N1CCN(C[C@@H]2CCCN(C3CC3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036766 | 75241 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 410 | 4 | 1 | 3 | 3.7 | O=C(Nc1cccc(C(F)(F)F)c1)N1CCN(C[C@@H]2CCCN(C3CC3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
44442590 | 93825 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 169 | 2 | ChEMBL | 606 | 11 | 6 | 5 | 3.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL247455 | 93825 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 169 | 2 | ChEMBL | 606 | 11 | 6 | 5 | 3.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
44442593 | 147288 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 549 | 11 | 5 | 5 | 3.7 | CCNc1cc(C(=O)NCC(=O)N[C@@H](CNCc2ccc(C)cc2C)C(=O)NC(C)(C)C)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL392814 | 147288 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 549 | 11 | 5 | 5 | 3.7 | CCNc1cc(C(=O)NCC(=O)N[C@@H](CNCc2ccc(C)cc2C)C(=O)NC(C)(C)C)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.07.028 | |||
11647276 | 75233 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 412 | 4 | 1 | 3 | 4.3 | CC(C)N1CCC[C@@H](CN2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036758 | 75233 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 412 | 4 | 1 | 3 | 4.3 | CC(C)N1CCC[C@@H](CN2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
70681778 | 75243 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 367 | 4 | 1 | 4 | 2.6 | N#Cc1cccc(NC(=O)N2CCN(C[C@@H]3CCCN(C4CC4)C3)CC2)c1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036768 | 75243 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 367 | 4 | 1 | 4 | 2.6 | N#Cc1cccc(NC(=O)N2CCN(C[C@@H]3CCCN(C4CC4)C3)CC2)c1 | 10.1016/j.bmcl.2012.04.118 | |||
11690139 | 75251 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 412 | 3 | 1 | 3 | 3.4 | CCN1CCC[C@@H](C(=O)N2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036778 | 75251 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 412 | 3 | 1 | 3 | 3.4 | CCN1CCC[C@@H](C(=O)N2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
57656719 | 75242 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 410 | 4 | 1 | 3 | 3.7 | O=C(Nc1ccc(C(F)(F)F)cc1)N1CCN(C[C@@H]2CCCN(C3CC3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036767 | 75242 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 410 | 4 | 1 | 3 | 3.7 | O=C(Nc1ccc(C(F)(F)F)cc1)N1CCN(C[C@@H]2CCCN(C3CC3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
56643545 | 68982 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 520 | 7 | 3 | 3 | 4.9 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)cc(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922823 | 68982 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 520 | 7 | 3 | 3 | 4.9 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)cc(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
44580591 | 187965 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 551 | 9 | 4 | 6 | 3.1 | CCCN1CCC(NC(=O)c2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(N)cc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL496344 | 187965 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 551 | 9 | 4 | 6 | 3.1 | CCCN1CCC(NC(=O)c2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(N)cc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2008.07.123 | |||
44571218 | 183984 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 523 | 7 | 5 | 6 | 2.5 | CSc1ccc(C(=O)NC2CC(N)CCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
CHEMBL481009 | 183984 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 523 | 7 | 5 | 6 | 2.5 | CSc1ccc(C(=O)NC2CC(N)CCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
22143258 | 183985 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 522 | 9 | 3 | 5 | 3.9 | CSc1ccc(CNC2CC(N(C)C)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
CHEMBL481010 | 183985 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 522 | 9 | 3 | 5 | 3.9 | CSc1ccc(CNC2CC(N(C)C)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
11584094 | 189040 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 494 | 6 | 2 | 4 | 4.3 | O=C(/C=C/c1cc(F)cc(F)c1)N1CCC(C(CO)N2CCC(c3c[nH]c4ncccc34)CC2)CC1 | 10.1016/j.bmcl.2008.10.061 | |||
CHEMBL508015 | 189040 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 494 | 6 | 2 | 4 | 4.3 | O=C(/C=C/c1cc(F)cc(F)c1)N1CCC(C(CO)N2CCC(c3c[nH]c4ncccc34)CC2)CC1 | 10.1016/j.bmcl.2008.10.061 | |||
11613399 | 189053 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 526 | 6 | 2 | 4 | 5.4 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)N1CCC(C(CO)N2CCC(c3c[nH]c4ncccc34)CC2)CC1 | 10.1016/j.bmcl.2008.10.061 | |||
CHEMBL508073 | 189053 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 526 | 6 | 2 | 4 | 5.4 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)N1CCC(C(CO)N2CCC(c3c[nH]c4ncccc34)CC2)CC1 | 10.1016/j.bmcl.2008.10.061 | |||
11527661 | 2021 | None | 28 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 520 | 7 | 3 | 6 | 2.9 | COc1ccc(cn1)C1(O)CCC(CC1)N1CC[C@H](C1)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200030q | |||
9045 | 2021 | None | 28 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 520 | 7 | 3 | 6 | 2.9 | COc1ccc(cn1)C1(O)CCC(CC1)N1CC[C@H](C1)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200030q | |||
CHEMBL1963131 | 2021 | None | 28 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 520 | 7 | 3 | 6 | 2.9 | COc1ccc(cn1)C1(O)CCC(CC1)N1CC[C@H](C1)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200030q | |||
11353843 | 74573 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 594 | 6 | 2 | 7 | 4.8 | O=C(C1CCN(c2cccc(C(F)(F)F)c2)CC1)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncccn4)cn3)CC2)C1 | 10.1021/ml200199c | |||
CHEMBL2029566 | 74573 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 594 | 6 | 2 | 7 | 4.8 | O=C(C1CCN(c2cccc(C(F)(F)F)c2)CC1)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncccn4)cn3)CC2)C1 | 10.1021/ml200199c | |||
44453329 | 155441 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 431 | 7 | 2 | 3 | 3.5 | C=Cc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL403281 | 155441 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 431 | 7 | 2 | 3 | 3.5 | C=Cc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
53325639 | 58487 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 1 | 2 | ChEMBL | 498 | 6 | 1 | 6 | 3.3 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cccc(C(F)(F)F)n3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.015 | |||
CHEMBL1683073 | 58487 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 1 | 2 | ChEMBL | 498 | 6 | 1 | 6 | 3.3 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cccc(C(F)(F)F)n3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.015 | |||
54583111 | 62565 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 512 | 6 | 0 | 6 | 3.7 | CO[C@@H]1COCC[C@@H]1N(C)[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782377 | 62565 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 512 | 6 | 0 | 6 | 3.7 | CO[C@@H]1COCC[C@@H]1N(C)[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
44583281 | 188342 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 626 | 9 | 3 | 6 | 4.5 | CSc1ccc(S(=O)(=O)C[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N2CCC2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL499467 | 188342 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 626 | 9 | 3 | 6 | 4.5 | CSc1ccc(S(=O)(=O)C[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N2CCC2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
11421712 | 74569 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4cnccn4)cn3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
CHEMBL2029421 | 74569 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4cnccn4)cn3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
50925394 | 19335 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 2 | 2 | ChEMBL | 517 | 8 | 2 | 4 | 4.4 | CCO[C@H]1CN([C@H]2CC[C@@H](c3ccccc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.10.020 | |||
CHEMBL1290636 | 19335 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 2 | 2 | ChEMBL | 517 | 8 | 2 | 4 | 4.4 | CCO[C@H]1CN([C@H]2CC[C@@H](c3ccccc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.10.020 | |||
53324304 | 58481 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 3 | 2 | ChEMBL | 497 | 6 | 1 | 5 | 3.9 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cccc(C(F)(F)F)c3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.015 | |||
CHEMBL1683067 | 58481 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 3 | 2 | ChEMBL | 497 | 6 | 1 | 5 | 3.9 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cccc(C(F)(F)F)c3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.015 | |||
46240484 | 83612 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 496 | 6 | 3 | 6 | 2.8 | Cc1cnc([C@]2(O)CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)s1 | 10.1021/ml300260s | |||
CHEMBL2204261 | 83612 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 496 | 6 | 3 | 6 | 2.8 | Cc1cnc([C@]2(O)CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)s1 | 10.1021/ml300260s | |||
57394969 | 68962 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 499 | 7 | 2 | 3 | 4.5 | NC(=O)C(NC1CCC(c2ccccc2)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922798 | 68962 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 499 | 7 | 2 | 3 | 4.5 | NC(=O)C(NC1CCC(c2ccccc2)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
44421888 | 85227 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 307 | 4 | 1 | 3 | 3.6 | c1ccc(CN2CCC(Oc3ccc4[nH]ncc4c3)CC2)cc1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL225434 | 85227 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 307 | 4 | 1 | 3 | 3.6 | c1ccc(CN2CCC(Oc3ccc4[nH]ncc4c3)CC2)cc1 | 10.1016/j.bmc.2006.09.052 | |||
44421862 | 136467 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 312 | 4 | 2 | 4 | 3.7 | c1csc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)c1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL373512 | 136467 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 312 | 4 | 2 | 4 | 3.7 | c1csc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)c1 | 10.1016/j.bmc.2006.09.052 | |||
145961982 | 161626 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 10 | 2 | ChEMBL | 553 | 8 | 1 | 6 | 4.3 | CN(C1CCN(CCCN2CCCc3c(ccnc3Nc3ccc(Cl)c(Cl)c3)C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
CHEMBL4128498 | 161626 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 10 | 2 | ChEMBL | 553 | 8 | 1 | 6 | 4.3 | CN(C1CCN(CCCN2CCCc3c(ccnc3Nc3ccc(Cl)c(Cl)c3)C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
122181237 | 121918 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 574 | 7 | 2 | 4 | 6.0 | O=C(NCc1cc(F)cc(C(F)(F)F)c1)C(CCN1CCC2(CC1)OCCc1cc(O)ccc12)c1ccc(F)cc1 | 10.1016/j.bmc.2015.02.019 | |||
CHEMBL3589951 | 121918 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 574 | 7 | 2 | 4 | 6.0 | O=C(NCc1cc(F)cc(C(F)(F)F)c1)C(CCN1CCC2(CC1)OCCc1cc(O)ccc12)c1ccc(F)cc1 | 10.1016/j.bmc.2015.02.019 | |||
46842232 | 7884 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 544 | 8 | 2 | 4 | 3.9 | Cc1ccc(C(=O)N2CCC(CCN3CC[C@@H](NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cc1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1089965 | 7884 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 544 | 8 | 2 | 4 | 3.9 | Cc1ccc(C(=O)N2CCC(CCN3CC[C@@H](NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cc1 | 10.1016/j.bmcl.2010.02.072 | |||
11567495 | 75225 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 398 | 4 | 1 | 3 | 3.9 | CCN1CCCC(CN2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036750 | 75225 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 398 | 4 | 1 | 3 | 3.9 | CCN1CCCC(CN2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
24801526 | 97669 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 541 | 7 | 5 | 6 | 1.5 | Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@H]1CCCC[C@H]1NC(=O)c1ccc(S(N)(=O)=O)cc1 | 10.1021/jm701488f | |||
CHEMBL270959 | 97669 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 541 | 7 | 5 | 6 | 1.5 | Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@H]1CCCC[C@H]1NC(=O)c1ccc(S(N)(=O)=O)cc1 | 10.1021/jm701488f | |||
145953762 | 161528 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 539 | 8 | 1 | 6 | 3.9 | CN(C1CCN(CCCN2CCc3c(ccnc3Nc3ccc(Cl)c(Cl)c3)C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
CHEMBL4127135 | 161528 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 539 | 8 | 1 | 6 | 3.9 | CN(C1CCN(CCCN2CCc3c(ccnc3Nc3ccc(Cl)c(Cl)c3)C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
10240278 | 173000 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 654 | 10 | 4 | 6 | 5.4 | CSc1ccc(S(=O)(=O)C[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC2CCCC2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL451597 | 173000 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 654 | 10 | 4 | 6 | 5.4 | CSc1ccc(S(=O)(=O)C[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC2CCCC2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
57344298 | 68974 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 502 | 7 | 3 | 3 | 4.7 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922814 | 68974 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 502 | 7 | 3 | 3 | 4.7 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
44453409 | 95492 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 419 | 6 | 2 | 3 | 3.1 | Cc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL257065 | 95492 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 419 | 6 | 2 | 3 | 3.1 | Cc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
57656715 | 75232 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 410 | 4 | 1 | 3 | 4.0 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(C[C@@H]2CCCN(C3CC3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036757 | 75232 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 410 | 4 | 1 | 3 | 4.0 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(C[C@@H]2CCCN(C3CC3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
57344315 | 68963 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 530 | 8 | 2 | 5 | 3.9 | COc1ccc(C2CCC(NC(C(N)=O)C3CCN(C(=O)/C=C/c4cc(F)c(F)c(F)c4)CC3)CC2)cn1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922799 | 68963 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 530 | 8 | 2 | 5 | 3.9 | COc1ccc(C2CCC(NC(C(N)=O)C3CCN(C(=O)/C=C/c4cc(F)c(F)c(F)c4)CC3)CC2)cn1 | 10.1016/j.bmcl.2011.09.113 | |||
44447436 | 154782 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 512 | 9 | 1 | 2 | 6.8 | C=CCC(CCN1CCC(c2ccccc2)CC1)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL399717 | 154782 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 512 | 9 | 1 | 2 | 6.8 | C=CCC(CCN1CCC(c2ccccc2)CC1)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.01.023 | |||
44447436 | 154782 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 512 | 9 | 1 | 2 | 6.8 | C=CCC(CCN1CCC(c2ccccc2)CC1)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL399717 | 154782 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 512 | 9 | 1 | 2 | 6.8 | C=CCC(CCN1CCC(c2ccccc2)CC1)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2008.01.023 | |||
46240785 | 83615 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 510 | 7 | 3 | 6 | 3.1 | CCc1ncc([C@]2(O)CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)s1 | 10.1021/ml300260s | |||
CHEMBL2204264 | 83615 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 510 | 7 | 3 | 6 | 3.1 | CCc1ncc([C@]2(O)CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)s1 | 10.1021/ml300260s | |||
23630215 | 62564 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 508 | 5 | 1 | 5 | 4.3 | CC(C)[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)CC[C@@H](NC2C3CCCC2COC3)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782376 | 62564 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 508 | 5 | 1 | 5 | 4.3 | CC(C)[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)CC[C@@H](NC2C3CCCC2COC3)C1 | 10.1016/j.bmcl.2011.01.034 | |||
54754724 | 65775 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 479 | 9 | 2 | 6 | 3.6 | C=CCOC[C@H]1CC[C@@H](N2CC(NC(=O)CNc3nn(C)c4ccc(C(F)(F)F)cc34)C2)CC1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834645 | 65775 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 479 | 9 | 2 | 6 | 3.6 | C=CCOC[C@H]1CC[C@@H](N2CC(NC(=O)CNc3nn(C)c4ccc(C(F)(F)F)cc34)C2)CC1 | 10.1016/j.bmcl.2011.08.074 | |||
54580190 | 62591 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 512 | 7 | 1 | 6 | 3.7 | CCO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782577 | 62591 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 512 | 7 | 1 | 6 | 3.7 | CCO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
46842235 | 7838 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 598 | 8 | 2 | 4 | 4.6 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCC2CCN(C(=O)c3ccc(C(F)(F)F)cc3)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1089629 | 7838 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 598 | 8 | 2 | 4 | 4.6 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCC2CCN(C(=O)c3ccc(C(F)(F)F)cc3)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
49764322 | 65462 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 505 | 7 | 3 | 5 | 3.1 | COc1ccc([C@]2(O)CC[C@@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cc1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829632 | 65462 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 505 | 7 | 3 | 5 | 3.1 | COc1ccc([C@]2(O)CC[C@@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cc1 | 10.1016/j.bmcl.2011.06.080 | |||
11365166 | 74570 | None | 1 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 573 | 7 | 3 | 7 | 4.0 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4nccs4)cn3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
CHEMBL2029423 | 74570 | None | 1 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 573 | 7 | 3 | 7 | 4.0 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4nccs4)cn3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
135981707 | 65811 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 556 | 8 | 2 | 6 | 4.3 | CCOC(=O)[C@H]1CC[C@@H](N2CC(NC(=O)CNC3=NC(Cc4ccccc4)c4ccc(C(F)(F)F)cc43)C2)CC1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834783 | 65811 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 556 | 8 | 2 | 6 | 4.3 | CCOC(=O)[C@H]1CC[C@@H](N2CC(NC(=O)CNC3=NC(Cc4ccccc4)c4ccc(C(F)(F)F)cc43)C2)CC1 | 10.1016/j.bmcl.2011.08.074 | |||
44425654 | 86264 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 2 | 2 | ChEMBL | 532 | 5 | 1 | 3 | 6.4 | CS[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL231247 | 86264 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 2 | 2 | ChEMBL | 532 | 5 | 1 | 3 | 6.4 | CS[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
44425654 | 86264 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 2 | 2 | ChEMBL | 532 | 5 | 1 | 3 | 6.4 | CS[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL231247 | 86264 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 2 | 2 | ChEMBL | 532 | 5 | 1 | 3 | 6.4 | CS[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
57344316 | 68956 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 554 | 7 | 4 | 4 | 5.0 | O=C(NO)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922792 | 68956 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 554 | 7 | 4 | 4 | 5.0 | O=C(NO)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
46240687 | 83618 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 528 | 7 | 3 | 7 | 3.2 | CSc1ncc([C@]2(O)CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)s1 | 10.1021/ml300260s | |||
CHEMBL2204267 | 83618 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 528 | 7 | 3 | 7 | 3.2 | CSc1ncc([C@]2(O)CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)s1 | 10.1021/ml300260s | |||
44439166 | 90580 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 595 | 12 | 5 | 7 | 4.7 | COC(=O)[C@H](CCCNC(=N)N)NC(=O)CCNc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
CHEMBL238731 | 90580 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 595 | 12 | 5 | 7 | 4.7 | COC(=O)[C@H](CCCNC(=N)N)NC(=O)CCNc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
122181144 | 121898 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | 35 | 2 | ChEMBL | 514 | 6 | 1 | 3 | 5.7 | O=C(CCCN1CCC2(CC1)OCCc1ccccc12)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2015.02.019 | |||
CHEMBL3589839 | 121898 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | 35 | 2 | ChEMBL | 514 | 6 | 1 | 3 | 5.7 | O=C(CCCN1CCC2(CC1)OCCc1ccccc12)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmc.2015.02.019 | |||
10182382 | 94015 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 450 | 9 | 4 | 4 | 1.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(N)=O)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL248418 | 94015 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 450 | 9 | 4 | 4 | 1.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(N)=O)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
22143293 | 188133 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 495 | 8 | 5 | 6 | 2.4 | CSc1ccc(CNC2CCNCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL497577 | 188133 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 495 | 8 | 5 | 6 | 2.4 | CSc1ccc(CNC2CCNCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
44583282 | 172798 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 656 | 9 | 3 | 7 | 4.2 | CSc1ccc(S(=O)(=O)C[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N2CCOCC2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL450231 | 172798 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 656 | 9 | 3 | 7 | 4.2 | CSc1ccc(S(=O)(=O)C[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N2CCOCC2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
22143241 | 183356 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 510 | 8 | 3 | 4 | 3.8 | CN(C)C1CCC(NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(NCc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2008.12.062 | |||
CHEMBL479642 | 183356 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 510 | 8 | 3 | 4 | 3.8 | CN(C)C1CCC(NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(NCc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2008.12.062 | |||
56643545 | 68982 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 520 | 7 | 3 | 3 | 4.9 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)cc(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922823 | 68982 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 520 | 7 | 3 | 3 | 4.9 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)cc(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
11591595 | 186263 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 512 | 6 | 2 | 4 | 4.5 | O=C(/C=C/c1cc(F)c(F)c(F)c1)N1CCC(C(CO)N2CCC(c3c[nH]c4ncccc34)CC2)CC1 | 10.1016/j.bmcl.2008.10.061 | |||
CHEMBL487238 | 186263 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 512 | 6 | 2 | 4 | 4.5 | O=C(/C=C/c1cc(F)c(F)c(F)c1)N1CCC(C(CO)N2CCC(c3c[nH]c4ncccc34)CC2)CC1 | 10.1016/j.bmcl.2008.10.061 | |||
54755560 | 65800 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 495 | 8 | 2 | 7 | 3.4 | CCOC(=O)[C@H]1CC[C@@H](N2CC(NC(=O)CNc3nn(CC)c4ccc(C(F)(F)F)cc34)C2)CC1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834721 | 65800 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 495 | 8 | 2 | 7 | 3.4 | CCOC(=O)[C@H]1CC[C@@H](N2CC(NC(=O)CNc3nn(CC)c4ccc(C(F)(F)F)cc34)C2)CC1 | 10.1016/j.bmcl.2011.08.074 | |||
56661451 | 65819 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 500 | 6 | 2 | 6 | 4.2 | Cc1ccc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4nn(C)c5ccc(C(F)(F)F)cc45)C3)CC2)cn1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834791 | 65819 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 500 | 6 | 2 | 6 | 4.2 | Cc1ccc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4nn(C)c5ccc(C(F)(F)F)cc45)C3)CC2)cn1 | 10.1016/j.bmcl.2011.08.074 | |||
56683044 | 65823 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 521 | 6 | 3 | 8 | 3.4 | NC(=O)n1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](c4nccs4)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834795 | 65823 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 521 | 6 | 3 | 8 | 3.4 | NC(=O)n1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](c4nccs4)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
56662695 | 65826 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 520 | 7 | 2 | 7 | 4.6 | CCc1ncc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4nn(C)c5ccc(C(F)(F)F)cc45)C3)CC2)s1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834798 | 65826 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 520 | 7 | 2 | 7 | 4.6 | CCc1ncc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4nn(C)c5ccc(C(F)(F)F)cc45)C3)CC2)s1 | 10.1016/j.bmcl.2011.08.074 | |||
10232019 | 73756 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 584 | 14 | 5 | 5 | 5.1 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NCc1ccccc1 | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018394 | 73756 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 584 | 14 | 5 | 5 | 5.1 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NCc1ccccc1 | 10.1016/j.bmcl.2012.03.007 | |||
57398750 | 71040 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 491 | 6 | 3 | 6 | 2.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN([C@H]2CC[C@@](O)(c3ccnnc3)CC2)C1 | 10.1021/ml200030q | |||
CHEMBL1951775 | 71040 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 491 | 6 | 3 | 6 | 2.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN([C@H]2CC[C@@](O)(c3ccnnc3)CC2)C1 | 10.1021/ml200030q | |||
127025092 | 138310 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 414 | 2 | 2 | 6 | 1.5 | CC(C)(C)N1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3ncc(Cl)s3)CC2)C1 | 10.1039/C5MD00362H | |||
CHEMBL3770125 | 138310 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 414 | 2 | 2 | 6 | 1.5 | CC(C)(C)N1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3ncc(Cl)s3)CC2)C1 | 10.1039/C5MD00362H | |||
10152864 | 187980 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 543 | 8 | 3 | 6 | 3.2 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N)CC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL496432 | 187980 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 543 | 8 | 3 | 6 | 3.2 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N)CC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
57391768 | 71037 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 491 | 6 | 3 | 6 | 2.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN([C@H]2CC[C@@](O)(c3ccncn3)CC2)C1 | 10.1021/ml200030q | |||
CHEMBL1951772 | 71037 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 491 | 6 | 3 | 6 | 2.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN([C@H]2CC[C@@](O)(c3ccncn3)CC2)C1 | 10.1021/ml200030q | |||
25022597 | 95392 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 448 | 6 | 3 | 4 | 3.0 | Cc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)c(C)c1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL256629 | 95392 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 448 | 6 | 3 | 4 | 3.0 | Cc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)c(C)c1 | 10.1016/j.bmcl.2008.02.015 | |||
44425633 | 86075 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 1 | 2 | ChEMBL | 578 | 5 | 1 | 2 | 7.8 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL230721 | 86075 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 1 | 2 | ChEMBL | 578 | 5 | 1 | 2 | 7.8 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
44425633 | 86075 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 1 | 2 | ChEMBL | 578 | 5 | 1 | 2 | 7.8 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL230721 | 86075 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 1 | 2 | ChEMBL | 578 | 5 | 1 | 2 | 7.8 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
50991056 | 62586 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 499 | 6 | 1 | 7 | 2.7 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)cnn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782572 | 62586 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 499 | 6 | 1 | 7 | 2.7 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)cnn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
10008367 | 2022 | None | 36 | Mouse | Functional | pIC50 | = | 8.1 | 8.1 | -1 | 3 | ChEMBL | 577 | 8 | 3 | 7 | 3.2 | CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@@H]1CC[C@](CC1)(O)c1ccc2c(c1)OCO2 | 10.1016/j.bmcl.2010.10.020 | |||
777 | 2022 | None | 36 | Mouse | Functional | pIC50 | = | 8.1 | 8.1 | -1 | 3 | ChEMBL | 577 | 8 | 3 | 7 | 3.2 | CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@@H]1CC[C@](CC1)(O)c1ccc2c(c1)OCO2 | 10.1016/j.bmcl.2010.10.020 | |||
CHEMBL1289316 | 2022 | None | 36 | Mouse | Functional | pIC50 | = | 8.1 | 8.1 | -1 | 3 | ChEMBL | 577 | 8 | 3 | 7 | 3.2 | CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@@H]1CC[C@](CC1)(O)c1ccc2c(c1)OCO2 | 10.1016/j.bmcl.2010.10.020 | |||
CHEMBL2426341 | 2022 | None | 36 | Mouse | Functional | pIC50 | = | 8.1 | 8.1 | -1 | 3 | ChEMBL | 577 | 8 | 3 | 7 | 3.2 | CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@@H]1CC[C@](CC1)(O)c1ccc2c(c1)OCO2 | 10.1016/j.bmcl.2010.10.020 | |||
CHEMBL5268600 | 2022 | None | 36 | Mouse | Functional | pIC50 | = | 8.1 | 8.1 | -1 | 3 | ChEMBL | 577 | 8 | 3 | 7 | 3.2 | CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@@H]1CC[C@](CC1)(O)c1ccc2c(c1)OCO2 | 10.1016/j.bmcl.2010.10.020 | |||
44425635 | 153621 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 3 | 2 | ChEMBL | 592 | 6 | 1 | 2 | 8.2 | CC(C)C[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL398000 | 153621 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 3 | 2 | ChEMBL | 592 | 6 | 1 | 2 | 8.2 | CC(C)C[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
46240585 | 83616 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 524 | 7 | 3 | 6 | 3.6 | CC(C)c1ncc([C@]2(O)CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)s1 | 10.1021/ml300260s | |||
CHEMBL2204265 | 83616 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 524 | 7 | 3 | 6 | 3.6 | CC(C)c1ncc([C@]2(O)CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)s1 | 10.1021/ml300260s | |||
44353447 | 3775 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 433 | 6 | 2 | 3 | 3.4 | O=C(N[C@@H]1CCN(C1)Cc1ccc(cc1C)C)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1016/j.bmcl.2010.02.072 | |||
785 | 3775 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 433 | 6 | 2 | 3 | 3.4 | O=C(N[C@@H]1CCN(C1)Cc1ccc(cc1C)C)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL337246 | 3775 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 433 | 6 | 2 | 3 | 3.4 | O=C(N[C@@H]1CCN(C1)Cc1ccc(cc1C)C)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1016/j.bmcl.2010.02.072 | |||
10272003 | 58896 | None | 1 | Human | Functional | pIC50 | = | 6.2 | 6.2 | 2 | 3 | ChEMBL | 395 | 2 | 2 | 5 | 3.4 | Cc1nn(C)c2ncc(C(=O)NC(=O)Nc3ccc(F)c(C(F)(F)F)c3)cc12 | 10.1021/jm1012903 | |||
CHEMBL1688888 | 58896 | None | 1 | Human | Functional | pIC50 | = | 6.2 | 6.2 | 2 | 3 | ChEMBL | 395 | 2 | 2 | 5 | 3.4 | Cc1nn(C)c2ncc(C(=O)NC(=O)Nc3ccc(F)c(C(F)(F)F)c3)cc12 | 10.1021/jm1012903 | |||
10272003 | 58896 | None | 1 | Human | Functional | pIC50 | = | 6.2 | 6.2 | 2 | 3 | ChEMBL | 395 | 2 | 2 | 5 | 3.4 | Cc1nn(C)c2ncc(C(=O)NC(=O)Nc3ccc(F)c(C(F)(F)F)c3)cc12 | 10.1021/jm1012903 | |||
CHEMBL1688888 | 58896 | None | 1 | Human | Functional | pIC50 | = | 6.2 | 6.2 | 2 | 3 | ChEMBL | 395 | 2 | 2 | 5 | 3.4 | Cc1nn(C)c2ncc(C(=O)NC(=O)Nc3ccc(F)c(C(F)(F)F)c3)cc12 | 10.1021/jm1012903 | |||
21098469 | 142439 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 326 | 4 | 2 | 3 | 3.9 | Clc1ccccc1CN1CCC(Nc2ccc3[nH]ncc3c2)C1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL388742 | 142439 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 326 | 4 | 2 | 3 | 3.9 | Clc1ccccc1CN1CCC(Nc2ccc3[nH]ncc3c2)C1 | 10.1016/j.bmc.2006.09.052 | |||
54585108 | 62583 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 499 | 6 | 1 | 7 | 2.7 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3ccnc(C(F)(F)F)n3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782569 | 62583 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 499 | 6 | 1 | 7 | 2.7 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3ccnc(C(F)(F)F)n3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
54583187 | 62594 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 484 | 5 | 2 | 6 | 2.7 | CC(C)[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)CC[C@@H](N[C@H]2CCOC[C@H]2O)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782580 | 62594 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 484 | 5 | 2 | 6 | 2.7 | CC(C)[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)CC[C@@H](N[C@H]2CCOC[C@H]2O)C1 | 10.1016/j.bmcl.2011.01.034 | |||
46885214 | 7700 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 545 | 8 | 2 | 5 | 2.5 | CC(CN1CC[C@@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C1)N1CCN(C(=O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1088810 | 7700 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 545 | 8 | 2 | 5 | 2.5 | CC(CN1CC[C@@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C1)N1CCN(C(=O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.02.072 | |||
145960485 | 161645 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 546 | 6 | 1 | 4 | 7.0 | O=C1c2ccnc(Nc3ccc(Cl)c(Cl)c3)c2CCCN1CCCN1CCC2(C=Cc3ccccc32)CC1 | 10.1016/j.bmc.2018.05.027 | |||
CHEMBL4128742 | 161645 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 546 | 6 | 1 | 4 | 7.0 | O=C1c2ccnc(Nc3ccc(Cl)c(Cl)c3)c2CCCN1CCCN1CCC2(C=Cc3ccccc32)CC1 | 10.1016/j.bmc.2018.05.027 | |||
44442586 | 93864 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 521 | 9 | 5 | 5 | 2.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(N)cc(C(F)(F)F)c2)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL247621 | 93864 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 521 | 9 | 5 | 5 | 2.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(N)cc(C(F)(F)F)c2)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
54583112 | 62566 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 513 | 6 | 0 | 7 | 3.1 | CO[C@@H]1COCC[C@@H]1N(C)[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)cnn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782378 | 62566 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 513 | 6 | 0 | 7 | 3.1 | CO[C@@H]1COCC[C@@H]1N(C)[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)cnn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
46241826 | 83594 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 490 | 6 | 3 | 5 | 2.8 | Cc1ccc([C@]2(O)CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cn1 | 10.1021/ml300260s | |||
CHEMBL2204243 | 83594 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 490 | 6 | 3 | 5 | 2.8 | Cc1ccc([C@]2(O)CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cn1 | 10.1021/ml300260s | |||
145954490 | 161729 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 519 | 8 | 1 | 6 | 3.6 | CN(C1CCN(CCCN2CCCc3c(ccnc3Nc3ccc(Cl)cc3)C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
CHEMBL4130047 | 161729 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 519 | 8 | 1 | 6 | 3.6 | CN(C1CCN(CCCN2CCCc3c(ccnc3Nc3ccc(Cl)cc3)C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
70693849 | 73757 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 491 | 11 | 5 | 5 | 4.0 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNc1n[nH]c2ccc(C(F)(F)F)cc12 | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018395 | 73757 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 491 | 11 | 5 | 5 | 4.0 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNc1n[nH]c2ccc(C(F)(F)F)cc12 | 10.1016/j.bmcl.2012.03.007 | |||
44453507 | 169081 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 531 | 7 | 2 | 3 | 5.6 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccccc2-c2ccc3ccccc3c2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL439062 | 169081 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 531 | 7 | 2 | 3 | 5.6 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccccc2-c2ccc3ccccc3c2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
54583185 | 62584 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 499 | 6 | 1 | 7 | 2.7 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ncn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782570 | 62584 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 499 | 6 | 1 | 7 | 2.7 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ncn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
57393249 | 68983 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 520 | 7 | 3 | 3 | 4.9 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C\c2cc(F)cc(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922824 | 68983 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 520 | 7 | 3 | 3 | 4.9 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C\c2cc(F)cc(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
22143196 | 184093 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | -3 | 2 | ChEMBL | 509 | 7 | 5 | 6 | 2.0 | CSc1ccc(C(=O)NC2CCNCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL481790 | 184093 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | -3 | 2 | ChEMBL | 509 | 7 | 5 | 6 | 2.0 | CSc1ccc(C(=O)NC2CCNCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
22143196 | 184093 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | -3 | 2 | ChEMBL | 509 | 7 | 5 | 6 | 2.0 | CSc1ccc(C(=O)NC2CCNCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
CHEMBL481790 | 184093 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | -3 | 2 | ChEMBL | 509 | 7 | 5 | 6 | 2.0 | CSc1ccc(C(=O)NC2CCNCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
57656825 | 75234 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 394 | 4 | 1 | 3 | 3.5 | O=C(Nc1ccc(F)c(Cl)c1)N1CCN(C[C@@H]2CCCN(C3CC3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036759 | 75234 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 394 | 4 | 1 | 3 | 3.5 | O=C(Nc1ccc(F)c(Cl)c1)N1CCN(C[C@@H]2CCCN(C3CC3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
46842086 | 7981 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 544 | 8 | 2 | 4 | 3.9 | Cc1cccc(C(=O)N2CCC(CCN3CC[C@@H](NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)c1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1090548 | 7981 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 544 | 8 | 2 | 4 | 3.9 | Cc1cccc(C(=O)N2CCC(CCN3CC[C@@H](NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)c1 | 10.1016/j.bmcl.2010.02.072 | |||
122181145 | 121899 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | 1 | 2 | ChEMBL | 528 | 6 | 1 | 3 | 6.1 | CC1Cc2ccccc2C2(CCN(CCCC(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)O1 | 10.1016/j.bmc.2015.02.019 | |||
CHEMBL3589840 | 121899 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | 1 | 2 | ChEMBL | 528 | 6 | 1 | 3 | 6.1 | CC1Cc2ccccc2C2(CCN(CCCC(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)O1 | 10.1016/j.bmc.2015.02.019 | |||
44413411 | 77767 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 501 | 8 | 2 | 3 | 5.4 | CC1CCN(CCN[C@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL209002 | 77767 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 501 | 8 | 2 | 3 | 5.4 | CC1CCN(CCN[C@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/j.bmcl.2008.01.023 | |||
44413411 | 77767 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 501 | 8 | 2 | 3 | 5.4 | CC1CCN(CCN[C@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL209002 | 77767 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 501 | 8 | 2 | 3 | 5.4 | CC1CCN(CCN[C@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 | 10.1016/j.bmcl.2008.01.023 | |||
44453534 | 97934 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 451 | 7 | 3 | 5 | 2.5 | COc1cc(CN2CC[C@@H](NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)ccc1O | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL272331 | 97934 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 451 | 7 | 3 | 5 | 2.5 | COc1cc(CN2CC[C@@H](NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)ccc1O | 10.1016/j.bmcl.2008.02.015 | |||
44413144 | 139306 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | -1 | 2 | ChEMBL | 465 | 8 | 2 | 3 | 4.4 | CN(C)CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL378784 | 139306 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | -1 | 2 | ChEMBL | 465 | 8 | 2 | 3 | 4.4 | CN(C)CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1016/j.bmcl.2008.01.023 | |||
44413144 | 139306 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | -1 | 2 | ChEMBL | 465 | 8 | 2 | 3 | 4.4 | CN(C)CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL378784 | 139306 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | -1 | 2 | ChEMBL | 465 | 8 | 2 | 3 | 4.4 | CN(C)CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1016/j.bmcl.2008.01.023 | |||
145960924 | 161639 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 581 | 10 | 1 | 6 | 4.2 | CN(C1CCN(CCCN2CCCc3c(ccnc3NCCc3ccc(Cl)c(Cl)c3)C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
CHEMBL4128658 | 161639 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 581 | 10 | 1 | 6 | 4.2 | CN(C1CCN(CCCN2CCCc3c(ccnc3NCCc3ccc(Cl)c(Cl)c3)C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
162658125 | 181202 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | 100 | 3 | ChEMBL | 471 | 6 | 2 | 4 | 5.9 | O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
CHEMBL4760108 | 181202 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | 100 | 3 | ChEMBL | 471 | 6 | 2 | 4 | 5.9 | O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
57335017 | 70362 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 1380 | 2 | ChEMBL | 595 | 8 | 4 | 6 | 2.8 | N[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N2CCC2)C[C@@H]1CS(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2011.12.057 | |||
CHEMBL1944776 | 70362 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 1380 | 2 | ChEMBL | 595 | 8 | 4 | 6 | 2.8 | N[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N2CCC2)C[C@@H]1CS(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2011.12.057 | |||
10142792 | 93794 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 26 | 2 | ChEMBL | 521 | 9 | 5 | 5 | 2.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL247245 | 93794 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 26 | 2 | ChEMBL | 521 | 9 | 5 | 5 | 2.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
22143112 | 188552 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 594 | 11 | 5 | 6 | 3.7 | CCCN1CCC(NCc2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC)C1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL502513 | 188552 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 594 | 11 | 5 | 6 | 3.7 | CCCN1CCC(NCc2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC)C1 | 10.1016/j.bmcl.2008.07.123 | |||
22143305 | 183718 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 506 | 9 | 3 | 5 | 3.2 | COc1ccc(CNC2CC(N(C)C)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
CHEMBL480228 | 183718 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 506 | 9 | 3 | 5 | 3.2 | COc1ccc(CNC2CC(N(C)C)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
44570781 | 192674 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 515 | 8 | 4 | 4 | 3.7 | CN(C)C1CCC(NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(NCc2ccc3[nH]ccc3c2)C1 | 10.1016/j.bmcl.2008.12.062 | |||
CHEMBL521275 | 192674 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 515 | 8 | 4 | 4 | 3.7 | CN(C)C1CCC(NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(NCc2ccc3[nH]ccc3c2)C1 | 10.1016/j.bmcl.2008.12.062 | |||
56664979 | 65764 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 529 | 6 | 2 | 7 | 4.3 | Cn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](c4ccc5c(c4)OCO5)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834635 | 65764 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 529 | 6 | 2 | 7 | 4.3 | Cn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](c4ccc5c(c4)OCO5)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
44425635 | 153621 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 3 | 2 | ChEMBL | 592 | 6 | 1 | 2 | 8.2 | CC(C)C[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL398000 | 153621 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 3 | 2 | ChEMBL | 592 | 6 | 1 | 2 | 8.2 | CC(C)C[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.023 | |||
11421840 | 77667 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 578 | 9 | 2 | 5 | 5.2 | CCc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2NC(=O)Cc2nc3cccc(C(F)(F)F)c3[nH]2)cc1 | 10.1016/j.bmcl.2012.08.002 | |||
CHEMBL2088379 | 77667 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 578 | 9 | 2 | 5 | 5.2 | CCc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2NC(=O)Cc2nc3cccc(C(F)(F)F)c3[nH]2)cc1 | 10.1016/j.bmcl.2012.08.002 | |||
11273379 | 74574 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 595 | 6 | 2 | 8 | 4.2 | O=C(C1CCN(c2cccc(C(F)(F)F)n2)CC1)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncccn4)cn3)CC2)C1 | 10.1021/ml200199c | |||
CHEMBL2029567 | 74574 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 595 | 6 | 2 | 8 | 4.2 | O=C(C1CCN(c2cccc(C(F)(F)F)n2)CC1)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncccn4)cn3)CC2)C1 | 10.1021/ml200199c | |||
44453365 | 97580 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 465 | 7 | 4 | 6 | 2.0 | COc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)cc1N | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL270435 | 97580 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 465 | 7 | 4 | 6 | 2.0 | COc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)cc1N | 10.1016/j.bmcl.2008.02.015 | |||
53322810 | 58489 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 2 | ChEMBL | 499 | 6 | 1 | 7 | 2.7 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3nccc(C(F)(F)F)n3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.015 | |||
CHEMBL1683075 | 58489 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 2 | ChEMBL | 499 | 6 | 1 | 7 | 2.7 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3nccc(C(F)(F)F)n3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.015 | |||
44425630 | 86061 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 14 | 2 | ChEMBL | 550 | 4 | 1 | 2 | 7.2 | C[C@H]1CN([C@@H]2CC[C@](C)(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL230617 | 86061 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 14 | 2 | ChEMBL | 550 | 4 | 1 | 2 | 7.2 | C[C@H]1CN([C@@H]2CC[C@](C)(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
9956238 | 60218 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | 3 | 4 | ChEMBL | 467 | 8 | 2 | 8 | 3.0 | Cc1nn(C)c2nc(N(C)CCN(C)C)c(C(=O)NC(=O)Nc3cccc(OC(C)C)c3)cc12 | 10.1021/jm1012903 | |||
CHEMBL1688889 | 60218 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | 3 | 4 | ChEMBL | 467 | 8 | 2 | 8 | 3.0 | Cc1nn(C)c2nc(N(C)CCN(C)C)c(C(=O)NC(=O)Nc3cccc(OC(C)C)c3)cc12 | 10.1021/jm1012903 | |||
CHEMBL1739922 | 60218 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | 3 | 4 | ChEMBL | 467 | 8 | 2 | 8 | 3.0 | Cc1nn(C)c2nc(N(C)CCN(C)C)c(C(=O)NC(=O)Nc3cccc(OC(C)C)c3)cc12 | 10.1021/jm1012903 | |||
9956238 | 60218 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | 3 | 4 | ChEMBL | 467 | 8 | 2 | 8 | 3.0 | Cc1nn(C)c2nc(N(C)CCN(C)C)c(C(=O)NC(=O)Nc3cccc(OC(C)C)c3)cc12 | 10.1021/jm1012903 | |||
CHEMBL1688889 | 60218 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | 3 | 4 | ChEMBL | 467 | 8 | 2 | 8 | 3.0 | Cc1nn(C)c2nc(N(C)CCN(C)C)c(C(=O)NC(=O)Nc3cccc(OC(C)C)c3)cc12 | 10.1021/jm1012903 | |||
CHEMBL1739922 | 60218 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | 3 | 4 | ChEMBL | 467 | 8 | 2 | 8 | 3.0 | Cc1nn(C)c2nc(N(C)CCN(C)C)c(C(=O)NC(=O)Nc3cccc(OC(C)C)c3)cc12 | 10.1021/jm1012903 | |||
21098478 | 142727 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 340 | 4 | 2 | 3 | 4.3 | Clc1cccc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)c1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL389168 | 142727 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 340 | 4 | 2 | 3 | 4.3 | Clc1cccc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)c1 | 10.1016/j.bmc.2006.09.052 | |||
21098468 | 144761 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 340 | 4 | 2 | 3 | 4.3 | Clc1ccccc1CN1CCCC(Nc2ccc3[nH]ncc3c2)C1 | 10.1016/j.bmc.2006.09.052 | |||
CHEMBL390837 | 144761 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 340 | 4 | 2 | 3 | 4.3 | Clc1ccccc1CN1CCCC(Nc2ccc3[nH]ncc3c2)C1 | 10.1016/j.bmc.2006.09.052 | |||
68616341 | 73759 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 479 | 11 | 4 | 4 | 4.1 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CC(=O)Nc1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018397 | 73759 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 479 | 11 | 4 | 4 | 4.1 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CC(=O)Nc1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2012.03.007 | |||
57400161 | 68948 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 553 | 7 | 2 | 3 | 5.9 | CN(C1CCC(c2c[nH]c3ccccc23)CC1)C(C(=O)O)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922784 | 68948 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 553 | 7 | 2 | 3 | 5.9 | CN(C1CCC(c2c[nH]c3ccccc23)CC1)C(C(=O)O)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
44442598 | 154476 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 465 | 9 | 5 | 5 | 1.4 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2N)C(N)=O)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL398747 | 154476 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 465 | 9 | 5 | 5 | 1.4 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2N)C(N)=O)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
11843812 | 79935 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 563 | 9 | 2 | 3 | 6.6 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](NCCN1CCC(c2ccccc2)CC1)c1ccccc1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL212423 | 79935 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 563 | 9 | 2 | 3 | 6.6 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](NCCN1CCC(c2ccccc2)CC1)c1ccccc1 | 10.1016/j.bmcl.2008.01.023 | |||
11606702 | 145842 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 580 | 14 | 1 | 5 | 7.8 | CCC(CCCN(CC)CC)NC(=O)CCOc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
CHEMBL391662 | 145842 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 580 | 14 | 1 | 5 | 7.8 | CCC(CCCN(CC)CC)NC(=O)CCOc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
57344307 | 68960 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 539 | 7 | 3 | 4 | 4.4 | NC(=O)C(NC1CCC(c2c[nH]c3ccncc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922796 | 68960 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 539 | 7 | 3 | 4 | 4.4 | NC(=O)C(NC1CCC(c2c[nH]c3ccncc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
44413399 | 79560 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 501 | 8 | 2 | 3 | 5.5 | CC1CCCCN1CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL211404 | 79560 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 501 | 8 | 2 | 3 | 5.5 | CC1CCCCN1CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2008.01.023 | |||
11843812 | 79935 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 563 | 9 | 2 | 3 | 6.6 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](NCCN1CCC(c2ccccc2)CC1)c1ccccc1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL212423 | 79935 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 563 | 9 | 2 | 3 | 6.6 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](NCCN1CCC(c2ccccc2)CC1)c1ccccc1 | 10.1016/j.bmcl.2008.01.023 | |||
44413399 | 79560 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 501 | 8 | 2 | 3 | 5.5 | CC1CCCCN1CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL211404 | 79560 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 501 | 8 | 2 | 3 | 5.5 | CC1CCCCN1CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2008.01.023 | |||
10187492 | 147878 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 549 | 11 | 5 | 5 | 3.7 | CCNc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@@H](CNCc1ccc(C)cc1C)C(=O)NC(C)(C)C | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL393267 | 147878 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 549 | 11 | 5 | 5 | 3.7 | CCNc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@@H](CNCc1ccc(C)cc1C)C(=O)NC(C)(C)C | 10.1016/j.bmcl.2007.07.028 | |||
54754723 | 65774 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 467 | 8 | 2 | 6 | 3.4 | CCOC[C@H]1CC[C@@H](N2CC(NC(=O)CNc3nn(C)c4ccc(C(F)(F)F)cc34)C2)CC1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834644 | 65774 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 467 | 8 | 2 | 6 | 3.4 | CCOC[C@H]1CC[C@@H](N2CC(NC(=O)CNc3nn(C)c4ccc(C(F)(F)F)cc34)C2)CC1 | 10.1016/j.bmcl.2011.08.074 | |||
57394967 | 68950 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 509 | 6 | 2 | 2 | 6.5 | CC(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922786 | 68950 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 509 | 6 | 2 | 2 | 6.5 | CC(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
44413137 | 78923 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 453 | 8 | 2 | 4 | 4.3 | CN(C)CCN[C@@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cccs1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL211292 | 78923 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 453 | 8 | 2 | 4 | 4.3 | CN(C)CCN[C@@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cccs1 | 10.1016/j.bmcl.2008.01.023 | |||
162658125 | 181202 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | 100 | 3 | ChEMBL | 471 | 6 | 2 | 4 | 5.9 | O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
CHEMBL4760108 | 181202 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | 100 | 3 | ChEMBL | 471 | 6 | 2 | 4 | 5.9 | O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
44425308 | 153795 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 627 | 9 | 3 | 5 | 6.6 | CNC(=O)Nc1nc([C@@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
CHEMBL398150 | 153795 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 627 | 9 | 3 | 5 | 6.6 | CNC(=O)Nc1nc([C@@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
44413137 | 78923 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 453 | 8 | 2 | 4 | 4.3 | CN(C)CCN[C@@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cccs1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL211292 | 78923 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 453 | 8 | 2 | 4 | 4.3 | CN(C)CCN[C@@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cccs1 | 10.1016/j.bmcl.2008.01.023 | |||
155514261 | 169939 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -1 | 2 | ChEMBL | 493 | 4 | 1 | 3 | 5.2 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1c1cccc(Br)c1)C1CC1 | 10.1021/acs.jmedchem.8b00605 | |||
CHEMBL4439854 | 169939 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -1 | 2 | ChEMBL | 493 | 4 | 1 | 3 | 5.2 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1c1cccc(Br)c1)C1CC1 | 10.1021/acs.jmedchem.8b00605 | |||
155514261 | 169939 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -1 | 2 | ChEMBL | 493 | 4 | 1 | 3 | 5.2 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1c1cccc(Br)c1)C1CC1 | 10.1021/acs.jmedchem.8b00605 | |||
CHEMBL4439854 | 169939 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | -1 | 2 | ChEMBL | 493 | 4 | 1 | 3 | 5.2 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1c1cccc(Br)c1)C1CC1 | 10.1021/acs.jmedchem.8b00605 | |||
11273379 | 74574 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 595 | 6 | 2 | 8 | 4.2 | O=C(C1CCN(c2cccc(C(F)(F)F)n2)CC1)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncccn4)cn3)CC2)C1 | 10.1021/ml200199c | |||
CHEMBL2029567 | 74574 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 595 | 6 | 2 | 8 | 4.2 | O=C(C1CCN(c2cccc(C(F)(F)F)n2)CC1)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncccn4)cn3)CC2)C1 | 10.1021/ml200199c | |||
122181150 | 121904 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | 125 | 2 | ChEMBL | 608 | 7 | 1 | 3 | 7.2 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC2(CC1)OCCc1ccccc12)c1ccc(F)cc1 | 10.1016/j.bmc.2015.02.019 | |||
CHEMBL3589845 | 121904 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | 125 | 2 | ChEMBL | 608 | 7 | 1 | 3 | 7.2 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC2(CC1)OCCc1ccccc12)c1ccc(F)cc1 | 10.1016/j.bmc.2015.02.019 | |||
781 | 3396 | None | 52 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 417 | 4 | 1 | 5 | 5.1 | O=C1Nc2ccc(cc2C2(O1)CCN(CC2)CCc1nc(oc1C)c1ccccc1)C | 10.1021/jm030862l | |||
9953769 | 3396 | None | 52 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 417 | 4 | 1 | 5 | 5.1 | O=C1Nc2ccc(cc2C2(O1)CCN(CC2)CCc1nc(oc1C)c1ccccc1)C | 10.1021/jm030862l | |||
CHEMBL134074 | 3396 | None | 52 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 417 | 4 | 1 | 5 | 5.1 | O=C1Nc2ccc(cc2C2(O1)CCN(CC2)CCc1nc(oc1C)c1ccccc1)C | 10.1021/jm030862l | |||
10165625 | 73754 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 536 | 13 | 5 | 5 | 4.3 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(C)C | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018392 | 73754 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 536 | 13 | 5 | 5 | 4.3 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(C)C | 10.1016/j.bmcl.2012.03.007 | |||
46884898 | 7719 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 564 | 8 | 2 | 4 | 4.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCC2CCN(C(=O)c3ccccc3Cl)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1088874 | 7719 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 564 | 8 | 2 | 4 | 4.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCC2CCN(C(=O)c3ccccc3Cl)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
46885027 | 8423 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 531 | 8 | 2 | 5 | 2.1 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCN2CCN(C(=O)c3ccccc3)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1093469 | 8423 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 531 | 8 | 2 | 5 | 2.1 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCN2CCN(C(=O)c3ccccc3)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
53325460 | 58511 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 2 | ChEMBL | 538 | 6 | 1 | 6 | 3.6 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@](CC(F)(F)F)(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)C1 | 10.1016/j.bmcl.2011.01.015 | |||
CHEMBL1683190 | 58511 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 2 | ChEMBL | 538 | 6 | 1 | 6 | 3.6 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@](CC(F)(F)F)(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)C1 | 10.1016/j.bmcl.2011.01.015 | |||
56671923 | 65760 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 471 | 6 | 3 | 4 | 4.5 | O=C(CNc1n[nH]c2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](c3ccccc3)CC2)C1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834631 | 65760 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 471 | 6 | 3 | 4 | 4.5 | O=C(CNc1n[nH]c2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](c3ccccc3)CC2)C1 | 10.1016/j.bmcl.2011.08.074 | |||
44425630 | 86061 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 14 | 2 | ChEMBL | 550 | 4 | 1 | 2 | 7.2 | C[C@H]1CN([C@@H]2CC[C@](C)(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL230617 | 86061 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 14 | 2 | ChEMBL | 550 | 4 | 1 | 2 | 7.2 | C[C@H]1CN([C@@H]2CC[C@](C)(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.023 | |||
127025089 | 138392 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 398 | 2 | 2 | 6 | 1.0 | CC(C)(C)N1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3ncc(F)s3)CC2)C1 | 10.1039/C5MD00362H | |||
CHEMBL3770951 | 138392 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 398 | 2 | 2 | 6 | 1.0 | CC(C)(C)N1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3ncc(F)s3)CC2)C1 | 10.1039/C5MD00362H | |||
44453325 | 155631 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 466 | 7 | 4 | 6 | 2.1 | COc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)cc1O | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL404269 | 155631 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 466 | 7 | 4 | 6 | 2.1 | COc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)cc1O | 10.1016/j.bmcl.2008.02.015 | |||
57395216 | 71036 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 491 | 6 | 3 | 6 | 2.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN([C@H]2CC[C@@](O)(c3ncccn3)CC2)C1 | 10.1021/ml200030q | |||
CHEMBL1951771 | 71036 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 491 | 6 | 3 | 6 | 2.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN([C@H]2CC[C@@](O)(c3ncccn3)CC2)C1 | 10.1021/ml200030q | |||
44453372 | 155834 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 433 | 7 | 2 | 3 | 3.4 | CCc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL405633 | 155834 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 433 | 7 | 2 | 3 | 3.4 | CCc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
10281715 | 73749 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 579 | 13 | 6 | 5 | 4.0 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)NC(C)C | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018387 | 73749 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 579 | 13 | 6 | 5 | 4.0 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)NC(C)C | 10.1016/j.bmcl.2012.03.007 | |||
54582217 | 62590 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 512 | 7 | 1 | 6 | 3.7 | CCO[C@H]1COCC[C@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782576 | 62590 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 512 | 7 | 1 | 6 | 3.7 | CCO[C@H]1COCC[C@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
57344314 | 68952 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 553 | 7 | 2 | 4 | 5.7 | COC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922788 | 68952 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 553 | 7 | 2 | 4 | 5.7 | COC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
57394968 | 68951 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 525 | 7 | 3 | 3 | 5.5 | O=C(/C=C/c1cc(F)c(F)c(F)c1)N1CCC(C(CO)NC2CCC(c3c[nH]c4ccccc34)CC2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922787 | 68951 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 525 | 7 | 3 | 3 | 5.5 | O=C(/C=C/c1cc(F)c(F)c(F)c1)N1CCC(C(CO)NC2CCC(c3c[nH]c4ccccc34)CC2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
57391487 | 68957 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 540 | 7 | 3 | 4 | 4.6 | NC(=O)C(NC1CCC(C2CNc3ccccc32)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922793 | 68957 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 540 | 7 | 3 | 4 | 4.6 | NC(=O)C(NC1CCC(C2CNc3ccccc32)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
70692344 | 75224 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 370 | 3 | 2 | 3 | 3.1 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(CC2CCCNC2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036749 | 75224 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 370 | 3 | 2 | 3 | 3.1 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(CC2CCCNC2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
57398493 | 68972 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 473 | 6 | 4 | 3 | 4.6 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)Nc2ccccc2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922811 | 68972 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 473 | 6 | 4 | 3 | 4.6 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)Nc2ccccc2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
44563071 | 186801 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 525 | 6 | 2 | 4 | 4.0 | NC(=O)C(C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1)N1CCC(c2c[nH]c3ncccc23)CC1 | 10.1016/j.bmcl.2008.10.061 | |||
CHEMBL488433 | 186801 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 525 | 6 | 2 | 4 | 4.0 | NC(=O)C(C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1)N1CCC(c2c[nH]c3ncccc23)CC1 | 10.1016/j.bmcl.2008.10.061 | |||
11632418 | 75223 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 384 | 3 | 1 | 3 | 3.5 | CN1CCCC(CN2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036748 | 75223 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 384 | 3 | 1 | 3 | 3.5 | CN1CCCC(CN2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
44415898 | 81152 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 536 | 7 | 1 | 2 | 6.8 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC2(C=Cc3ccccc32)CC1)C1CC1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL215654 | 81152 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 536 | 7 | 1 | 2 | 6.8 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC2(C=Cc3ccccc32)CC1)C1CC1 | 10.1016/j.bmcl.2008.01.023 | |||
44415898 | 81152 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 536 | 7 | 1 | 2 | 6.8 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC2(C=Cc3ccccc32)CC1)C1CC1 | 10.1016/j.bmcl.2008.01.023 | |||
CHEMBL215654 | 81152 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 536 | 7 | 1 | 2 | 6.8 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC2(C=Cc3ccccc32)CC1)C1CC1 | 10.1016/j.bmcl.2008.01.023 | |||
57344317 | 68954 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 552 | 7 | 3 | 3 | 5.3 | CNC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922790 | 68954 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 552 | 7 | 3 | 3 | 5.3 | CNC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
57344318 | 68955 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 566 | 7 | 2 | 3 | 5.6 | CN(C)C(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
CHEMBL1922791 | 68955 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 566 | 7 | 2 | 3 | 5.6 | CN(C)C(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | 10.1016/j.bmcl.2011.09.113 | |||
44453327 | 95148 | None | 24 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 439 | 6 | 2 | 3 | 3.5 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL255408 | 95148 | None | 24 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 439 | 6 | 2 | 3 | 3.5 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
57393497 | 69154 | None | 0 | Human | Functional | pKd | = | 6 | 6.0 | - | 0 | ChEMBL | 645 | 10 | 2 | 6 | 6.8 | COc1cc(C(=O)NCCN2CCCCC2)ccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924022 | 69154 | None | 0 | Human | Functional | pKd | = | 6 | 6.0 | - | 0 | ChEMBL | 645 | 10 | 2 | 6 | 6.8 | COc1cc(C(=O)NCCN2CCCCC2)ccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.10.038 | |||
15985912 | 84009 | None | 0 | Human | Functional | pKd | = | 5 | 5.0 | - | 0 | ChEMBL | 416 | 5 | 1 | 5 | 4.1 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
CHEMBL2207081 | 84009 | None | 0 | Human | Functional | pKd | = | 5 | 5.0 | - | 0 | ChEMBL | 416 | 5 | 1 | 5 | 4.1 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
57400128 | 69147 | None | 0 | Human | Functional | pKd | = | 5.9 | 5.9 | - | 0 | ChEMBL | 629 | 9 | 2 | 5 | 7.1 | Cc1cc(Oc2ccc(C(=O)NCCN3CCCCC3)cc2)c(NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1Cl | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924015 | 69147 | None | 0 | Human | Functional | pKd | = | 5.9 | 5.9 | - | 0 | ChEMBL | 629 | 9 | 2 | 5 | 7.1 | Cc1cc(Oc2ccc(C(=O)NCCN3CCCCC3)cc2)c(NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1Cl | 10.1016/j.bmcl.2011.10.038 | |||
57400125 | 69136 | None | 0 | Human | Functional | pKd | = | 5.8 | 5.8 | - | 0 | ChEMBL | 582 | 9 | 2 | 6 | 5.9 | O=C(NCCN1CCCCC1)c1ccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924004 | 69136 | None | 0 | Human | Functional | pKd | = | 5.8 | 5.8 | - | 0 | ChEMBL | 582 | 9 | 2 | 6 | 5.9 | O=C(NCCN1CCCCC1)c1ccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
44180522 | 69156 | None | 0 | Human | Functional | pKd | = | 6.6 | 6.6 | - | 0 | ChEMBL | 631 | 10 | 2 | 6 | 6.4 | COc1cc(C(=O)NCCN2CCCC2)ccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924024 | 69156 | None | 0 | Human | Functional | pKd | = | 6.6 | 6.6 | - | 0 | ChEMBL | 631 | 10 | 2 | 6 | 6.4 | COc1cc(C(=O)NCCN2CCCC2)ccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.10.038 | |||
57393496 | 69153 | None | 0 | Human | Functional | pKd | = | 5.6 | 5.6 | - | 0 | ChEMBL | 629 | 9 | 2 | 5 | 7.1 | Cc1cc(C(=O)NCCN2CCCCC2)ccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924021 | 69153 | None | 0 | Human | Functional | pKd | = | 5.6 | 5.6 | - | 0 | ChEMBL | 629 | 9 | 2 | 5 | 7.1 | Cc1cc(C(=O)NCCN2CCCCC2)ccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.10.038 | |||
57656833 | 75255 | None | 0 | Human | Functional | pKd | = | 8.5 | 8.5 | 4 | 4 | ChEMBL | 427 | 3 | 2 | 4 | 2.4 | CC(C)N1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036782 | 75255 | None | 0 | Human | Functional | pKd | = | 8.5 | 8.5 | 4 | 4 | ChEMBL | 427 | 3 | 2 | 4 | 2.4 | CC(C)N1CCN[C@@H](C(=O)N2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
57393219 | 69144 | None | 0 | Human | Functional | pKd | = | 5.5 | 5.5 | - | 0 | ChEMBL | 581 | 9 | 2 | 5 | 6.5 | O=C(NCCN1CCCCC1)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924012 | 69144 | None | 0 | Human | Functional | pKd | = | 5.5 | 5.5 | - | 0 | ChEMBL | 581 | 9 | 2 | 5 | 6.5 | O=C(NCCN1CCCCC1)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
57400127 | 69146 | None | 0 | Human | Functional | pKd | = | 6.4 | 6.4 | - | 0 | ChEMBL | 616 | 9 | 2 | 6 | 6.2 | O=C(NCCN1CCCCC1)c1ccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924014 | 69146 | None | 0 | Human | Functional | pKd | = | 6.4 | 6.4 | - | 0 | ChEMBL | 616 | 9 | 2 | 6 | 6.2 | O=C(NCCN1CCCCC1)c1ccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
57393220 | 69148 | None | 0 | Human | Functional | pKd | = | 6.4 | 6.4 | - | 0 | ChEMBL | 645 | 10 | 2 | 6 | 6.8 | COc1cc(Oc2ccc(C(=O)NCCN3CCCCC3)cc2)c(NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1Cl | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924016 | 69148 | None | 0 | Human | Functional | pKd | = | 6.4 | 6.4 | - | 0 | ChEMBL | 645 | 10 | 2 | 6 | 6.8 | COc1cc(Oc2ccc(C(=O)NCCN3CCCCC3)cc2)c(NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1Cl | 10.1016/j.bmcl.2011.10.038 | |||
57397001 | 69150 | None | 0 | Human | Functional | pKd | = | 6.4 | 6.4 | - | 0 | ChEMBL | 615 | 9 | 2 | 5 | 6.7 | Cc1cc(Oc2ccc(C(=O)NCCN3CCCC3)cc2)c(NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1Cl | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924018 | 69150 | None | 0 | Human | Functional | pKd | = | 6.4 | 6.4 | - | 0 | ChEMBL | 615 | 9 | 2 | 5 | 6.7 | Cc1cc(Oc2ccc(C(=O)NCCN3CCCC3)cc2)c(NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1Cl | 10.1016/j.bmcl.2011.10.038 | |||
57400420 | 69151 | None | 0 | Human | Functional | pKd | = | 6.4 | 6.4 | - | 0 | ChEMBL | 631 | 10 | 2 | 6 | 6.4 | COc1cc(Oc2ccc(C(=O)NCCN3CCCC3)cc2)c(NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1Cl | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924019 | 69151 | None | 0 | Human | Functional | pKd | = | 6.4 | 6.4 | - | 0 | ChEMBL | 631 | 10 | 2 | 6 | 6.4 | COc1cc(Oc2ccc(C(=O)NCCN3CCCC3)cc2)c(NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1Cl | 10.1016/j.bmcl.2011.10.038 | |||
57393495 | 69152 | None | 0 | Human | Functional | pKd | = | 5.4 | 5.4 | - | 0 | ChEMBL | 637 | 9 | 2 | 5 | 6.7 | O=C(NCCN1CCC(F)(F)C1)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924020 | 69152 | None | 0 | Human | Functional | pKd | = | 5.4 | 5.4 | - | 0 | ChEMBL | 637 | 9 | 2 | 5 | 6.7 | O=C(NCCN1CCC(F)(F)C1)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
57400129 | 69149 | None | 0 | Human | Functional | pKd | = | 6.3 | 6.3 | - | 0 | ChEMBL | 601 | 9 | 2 | 5 | 6.4 | O=C(NCCN1CCCC1)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924017 | 69149 | None | 0 | Human | Functional | pKd | = | 6.3 | 6.3 | - | 0 | ChEMBL | 601 | 9 | 2 | 5 | 6.4 | O=C(NCCN1CCCC1)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
57395221 | 69155 | None | 0 | Human | Functional | pKd | = | 6.3 | 6.3 | - | 0 | ChEMBL | 615 | 9 | 2 | 5 | 6.7 | Cc1cc(C(=O)NCCN2CCCC2)ccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924023 | 69155 | None | 0 | Human | Functional | pKd | = | 6.3 | 6.3 | - | 0 | ChEMBL | 615 | 9 | 2 | 5 | 6.7 | Cc1cc(C(=O)NCCN2CCCC2)ccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.10.038 | |||
57398458 | 69145 | None | 0 | Human | Functional | pKd | = | 6.2 | 6.2 | - | 0 | ChEMBL | 615 | 9 | 2 | 5 | 6.8 | O=C(NCCN1CCCCC1)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924013 | 69145 | None | 0 | Human | Functional | pKd | = | 6.2 | 6.2 | - | 0 | ChEMBL | 615 | 9 | 2 | 5 | 6.8 | O=C(NCCN1CCCCC1)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
16124598 | 10733 | None | 0 | Human | Functional | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 472 | 6 | 2 | 5 | 5.3 | O=C(O)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171008 | 10733 | None | 0 | Human | Functional | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 472 | 6 | 2 | 5 | 5.3 | O=C(O)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
49798435 | 10707 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 472 | 6 | 2 | 5 | 5.3 | O=C(O)c1cccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1170828 | 10707 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 472 | 6 | 2 | 5 | 5.3 | O=C(O)c1cccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1 | 10.1016/j.bmcl.2010.04.142 | |||
49798434 | 10706 | None | 0 | Human | Functional | pKi | = | 8.7 | 8.7 | - | 0 | ChEMBL | 490 | 6 | 2 | 5 | 5.5 | O=C(O)c1c(F)cccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1170827 | 10706 | None | 0 | Human | Functional | pKi | = | 8.7 | 8.7 | - | 0 | ChEMBL | 490 | 6 | 2 | 5 | 5.5 | O=C(O)c1c(F)cccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
49798461 | 10697 | None | 0 | Human | Functional | pKi | = | 8 | 8.0 | - | 0 | ChEMBL | 443 | 5 | 1 | 5 | 5.3 | Cc1ncccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1170725 | 10697 | None | 0 | Human | Functional | pKi | = | 8 | 8.0 | - | 0 | ChEMBL | 443 | 5 | 1 | 5 | 5.3 | Cc1ncccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
17756652 | 10734 | None | 0 | Human | Functional | pKi | = | 8 | 8.0 | - | 0 | ChEMBL | 473 | 6 | 2 | 6 | 4.7 | O=C(O)c1cncc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171011 | 10734 | None | 0 | Human | Functional | pKi | = | 8 | 8.0 | - | 0 | ChEMBL | 473 | 6 | 2 | 6 | 4.7 | O=C(O)c1cncc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1 | 10.1016/j.bmcl.2010.04.142 | |||
49798461 | 10697 | None | 0 | Human | Functional | pKi | = | 8 | 8.0 | - | 0 | ChEMBL | 443 | 5 | 1 | 5 | 5.3 | Cc1ncccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1170725 | 10697 | None | 0 | Human | Functional | pKi | = | 8 | 8.0 | - | 0 | ChEMBL | 443 | 5 | 1 | 5 | 5.3 | Cc1ncccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2011.10.038 | |||
57398458 | 69145 | None | 0 | Human | Functional | pKi | = | 8 | 8.0 | - | 0 | ChEMBL | 615 | 9 | 2 | 5 | 6.8 | O=C(NCCN1CCCCC1)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924013 | 69145 | None | 0 | Human | Functional | pKi | = | 8 | 8.0 | - | 0 | ChEMBL | 615 | 9 | 2 | 5 | 6.8 | O=C(NCCN1CCCCC1)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
57393220 | 69148 | None | 0 | Human | Functional | pKi | = | 8 | 8.0 | - | 0 | ChEMBL | 645 | 10 | 2 | 6 | 6.8 | COc1cc(Oc2ccc(C(=O)NCCN3CCCCC3)cc2)c(NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1Cl | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924016 | 69148 | None | 0 | Human | Functional | pKi | = | 8 | 8.0 | - | 0 | ChEMBL | 645 | 10 | 2 | 6 | 6.8 | COc1cc(Oc2ccc(C(=O)NCCN3CCCCC3)cc2)c(NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1Cl | 10.1016/j.bmcl.2011.10.038 | |||
15985914 | 84008 | None | 0 | Human | Functional | pKi | = | 7 | 7.0 | - | 0 | ChEMBL | 457 | 6 | 1 | 6 | 4.4 | O=S(=O)(Nc1cc(Cl)ccc1Cn1nnnc1C1CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
CHEMBL2207080 | 84008 | None | 0 | Human | Functional | pKi | = | 7 | 7.0 | - | 0 | ChEMBL | 457 | 6 | 1 | 6 | 4.4 | O=S(=O)(Nc1cc(Cl)ccc1Cn1nnnc1C1CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
15985914 | 84008 | None | 0 | Human | Functional | pKi | = | 7 | 7.0 | - | 0 | ChEMBL | 457 | 6 | 1 | 6 | 4.4 | O=S(=O)(Nc1cc(Cl)ccc1Cn1nnnc1C1CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
CHEMBL2207080 | 84008 | None | 0 | Human | Functional | pKi | = | 7 | 7.0 | - | 0 | ChEMBL | 457 | 6 | 1 | 6 | 4.4 | O=S(=O)(Nc1cc(Cl)ccc1Cn1nnnc1C1CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
15985912 | 84009 | None | 0 | Human | Functional | pKi | = | 7 | 7.0 | - | 0 | ChEMBL | 416 | 5 | 1 | 5 | 4.1 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
CHEMBL2207081 | 84009 | None | 0 | Human | Functional | pKi | = | 7 | 7.0 | - | 0 | ChEMBL | 416 | 5 | 1 | 5 | 4.1 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
57394938 | 69140 | None | 0 | Human | Functional | pKi | = | 7 | 7.0 | - | 0 | ChEMBL | 568 | 9 | 2 | 6 | 5.5 | O=C(NCCN1CCCC1)c1cccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924008 | 69140 | None | 0 | Human | Functional | pKi | = | 7 | 7.0 | - | 0 | ChEMBL | 568 | 9 | 2 | 6 | 5.5 | O=C(NCCN1CCCC1)c1cccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1 | 10.1016/j.bmcl.2011.10.038 | |||
57394938 | 69140 | None | 0 | Human | Functional | pKi | = | 6 | 6.0 | - | 0 | ChEMBL | 568 | 9 | 2 | 6 | 5.5 | O=C(NCCN1CCCC1)c1cccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924008 | 69140 | None | 0 | Human | Functional | pKi | = | 6 | 6.0 | - | 0 | ChEMBL | 568 | 9 | 2 | 6 | 5.5 | O=C(NCCN1CCCC1)c1cccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1 | 10.1016/j.bmcl.2011.10.038 | |||
49798291 | 10560 | None | 0 | Mouse | Functional | pKi | = | 6 | 6.0 | - | 0 | ChEMBL | 428 | 6 | 2 | 5 | 4.5 | N#Cc1ccc(Oc2ccccc2C(=O)O)c(NS(=O)(=O)c2ccc(Cl)cc2)c1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1169652 | 10560 | None | 0 | Mouse | Functional | pKi | = | 6 | 6.0 | - | 0 | ChEMBL | 428 | 6 | 2 | 5 | 4.5 | N#Cc1ccc(Oc2ccccc2C(=O)O)c(NS(=O)(=O)c2ccc(Cl)cc2)c1 | 10.1016/j.bmcl.2010.04.142 | |||
49798289 | 10653 | None | 0 | Mouse | Functional | pKi | = | 6 | 6.0 | - | 0 | ChEMBL | 489 | 6 | 2 | 4 | 5.8 | O=C(O)c1c(F)cccc1Oc1ccc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1170391 | 10653 | None | 0 | Mouse | Functional | pKi | = | 6 | 6.0 | - | 0 | ChEMBL | 489 | 6 | 2 | 4 | 5.8 | O=C(O)c1c(F)cccc1Oc1ccc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
49798289 | 10653 | None | 0 | Human | Functional | pKi | = | 5 | 5.0 | - | 0 | ChEMBL | 489 | 6 | 2 | 4 | 5.8 | O=C(O)c1c(F)cccc1Oc1ccc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1170391 | 10653 | None | 0 | Human | Functional | pKi | = | 5 | 5.0 | - | 0 | ChEMBL | 489 | 6 | 2 | 4 | 5.8 | O=C(O)c1c(F)cccc1Oc1ccc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
49798462 | 10599 | None | 0 | Human | Functional | pKi | = | 7.9 | 7.9 | - | 0 | ChEMBL | 463 | 5 | 1 | 5 | 5.7 | O=S(=O)(Nc1cc(Cl)cnc1Oc1cncc(Cl)c1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1169994 | 10599 | None | 0 | Human | Functional | pKi | = | 7.9 | 7.9 | - | 0 | ChEMBL | 463 | 5 | 1 | 5 | 5.7 | O=S(=O)(Nc1cc(Cl)cnc1Oc1cncc(Cl)c1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
44296310 | 188376 | None | 0 | Human | Functional | pKi | = | 5.9 | 5.9 | - | 0 | ChEMBL | 458 | 10 | 2 | 3 | 5.4 | CN(C)c1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL49994 | 188376 | None | 0 | Human | Functional | pKi | = | 5.9 | 5.9 | - | 0 | ChEMBL | 458 | 10 | 2 | 3 | 5.4 | CN(C)c1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/s0960-894x(00)00347-4 | |||
44296310 | 188376 | None | 0 | Human | Functional | pKi | = | 5.9 | 5.9 | - | 0 | ChEMBL | 458 | 10 | 2 | 3 | 5.4 | CN(C)c1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL49994 | 188376 | None | 0 | Human | Functional | pKi | = | 5.9 | 5.9 | - | 0 | ChEMBL | 458 | 10 | 2 | 3 | 5.4 | CN(C)c1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2007.12.072 | |||
44296310 | 188376 | None | 0 | Human | Functional | pKi | = | 5.9 | 5.9 | - | 0 | ChEMBL | 458 | 10 | 2 | 3 | 5.4 | CN(C)c1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL49994 | 188376 | None | 0 | Human | Functional | pKi | = | 5.9 | 5.9 | - | 0 | ChEMBL | 458 | 10 | 2 | 3 | 5.4 | CN(C)c1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2007.12.072 | |||
49798289 | 10653 | None | 0 | Human | Functional | pKi | = | 6.9 | 6.9 | - | 0 | ChEMBL | 489 | 6 | 2 | 4 | 5.8 | O=C(O)c1c(F)cccc1Oc1ccc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1170391 | 10653 | None | 0 | Human | Functional | pKi | = | 6.9 | 6.9 | - | 0 | ChEMBL | 489 | 6 | 2 | 4 | 5.8 | O=C(O)c1c(F)cccc1Oc1ccc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
9870980 | 154737 | None | 0 | Human | Functional | pKi | = | 6.9 | 6.9 | - | 0 | ChEMBL | 509 | 6 | 2 | 2 | 7.0 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@@H](CN2CCC(c3c[nH]c4ccccc34)CC2)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL399472 | 154737 | None | 0 | Human | Functional | pKi | = | 6.9 | 6.9 | - | 0 | ChEMBL | 509 | 6 | 2 | 2 | 7.0 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@@H](CN2CCC(c3c[nH]c4ccccc34)CC2)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
49798265 | 10732 | None | 0 | Human | Functional | pKi | = | 4.9 | 4.9 | - | 0 | ChEMBL | 489 | 6 | 2 | 4 | 5.8 | O=C(O)c1ccccc1Oc1c(F)cc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171006 | 10732 | None | 0 | Human | Functional | pKi | = | 4.9 | 4.9 | - | 0 | ChEMBL | 489 | 6 | 2 | 4 | 5.8 | O=C(O)c1ccccc1Oc1c(F)cc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
49798461 | 10697 | None | 0 | Human | Functional | pKi | = | 5.9 | 5.9 | - | 0 | ChEMBL | 443 | 5 | 1 | 5 | 5.3 | Cc1ncccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1170725 | 10697 | None | 0 | Human | Functional | pKi | = | 5.9 | 5.9 | - | 0 | ChEMBL | 443 | 5 | 1 | 5 | 5.3 | Cc1ncccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2011.10.038 | |||
57393218 | 69139 | None | 0 | Human | Functional | pKi | = | 5.9 | 5.9 | - | 0 | ChEMBL | 582 | 9 | 2 | 6 | 5.9 | O=C(NCCN1CCCCC1)c1cccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924007 | 69139 | None | 0 | Human | Functional | pKi | = | 5.9 | 5.9 | - | 0 | ChEMBL | 582 | 9 | 2 | 6 | 5.9 | O=C(NCCN1CCCCC1)c1cccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1 | 10.1016/j.bmcl.2011.10.038 | |||
9870980 | 154737 | None | 0 | Human | Functional | pKi | = | 6.9 | 6.9 | - | 0 | ChEMBL | 509 | 6 | 2 | 2 | 7.0 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@@H](CN2CCC(c3c[nH]c4ccccc34)CC2)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL399472 | 154737 | None | 0 | Human | Functional | pKi | = | 6.9 | 6.9 | - | 0 | ChEMBL | 509 | 6 | 2 | 2 | 7.0 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@@H](CN2CCC(c3c[nH]c4ccccc34)CC2)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
44296287 | 101742 | None | 0 | Human | Functional | pKi | = | 4.9 | 4.9 | - | 0 | ChEMBL | 472 | 10 | 3 | 3 | 5.3 | CC(=O)Nc1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL299379 | 101742 | None | 0 | Human | Functional | pKi | = | 4.9 | 4.9 | - | 0 | ChEMBL | 472 | 10 | 3 | 3 | 5.3 | CC(=O)Nc1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2007.12.072 | |||
57400125 | 69136 | None | 0 | Human | Functional | pKi | = | 7.9 | 7.9 | - | 0 | ChEMBL | 582 | 9 | 2 | 6 | 5.9 | O=C(NCCN1CCCCC1)c1ccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924004 | 69136 | None | 0 | Human | Functional | pKi | = | 7.9 | 7.9 | - | 0 | ChEMBL | 582 | 9 | 2 | 6 | 5.9 | O=C(NCCN1CCCCC1)c1ccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
57400126 | 69137 | None | 0 | Human | Functional | pKi | = | 7.9 | 7.9 | - | 0 | ChEMBL | 568 | 9 | 2 | 6 | 5.5 | O=C(NCCN1CCCC1)c1ccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924005 | 69137 | None | 0 | Human | Functional | pKi | = | 7.9 | 7.9 | - | 0 | ChEMBL | 568 | 9 | 2 | 6 | 5.5 | O=C(NCCN1CCCC1)c1ccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
44296265 | 194704 | None | 0 | Human | Functional | pKi | = | 5.8 | 5.8 | - | 0 | ChEMBL | 491 | 10 | 2 | 2 | 7.0 | O=C(/C=C/c1ccc(-c2ccccc2)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL53131 | 194704 | None | 0 | Human | Functional | pKi | = | 5.8 | 5.8 | - | 0 | ChEMBL | 491 | 10 | 2 | 2 | 7.0 | O=C(/C=C/c1ccc(-c2ccccc2)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
44296265 | 194704 | None | 0 | Human | Functional | pKi | = | 5.8 | 5.8 | - | 0 | ChEMBL | 491 | 10 | 2 | 2 | 7.0 | O=C(/C=C/c1ccc(-c2ccccc2)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL53131 | 194704 | None | 0 | Human | Functional | pKi | = | 5.8 | 5.8 | - | 0 | ChEMBL | 491 | 10 | 2 | 2 | 7.0 | O=C(/C=C/c1ccc(-c2ccccc2)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
44296265 | 194704 | None | 0 | Human | Functional | pKi | = | 5.8 | 5.8 | - | 0 | ChEMBL | 491 | 10 | 2 | 2 | 7.0 | O=C(/C=C/c1ccc(-c2ccccc2)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL53131 | 194704 | None | 0 | Human | Functional | pKi | = | 5.8 | 5.8 | - | 0 | ChEMBL | 491 | 10 | 2 | 2 | 7.0 | O=C(/C=C/c1ccc(-c2ccccc2)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
49798463 | 10600 | None | 0 | Human | Functional | pKi | = | 7.8 | 7.8 | - | 0 | ChEMBL | 454 | 5 | 1 | 6 | 4.9 | N#Cc1ccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cn1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1169995 | 10600 | None | 0 | Human | Functional | pKi | = | 7.8 | 7.8 | - | 0 | ChEMBL | 454 | 5 | 1 | 6 | 4.9 | N#Cc1ccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cn1 | 10.1016/j.bmcl.2010.04.142 | |||
49798289 | 10653 | None | 0 | Human | Functional | pKi | = | 6.8 | 6.8 | - | 0 | ChEMBL | 489 | 6 | 2 | 4 | 5.8 | O=C(O)c1c(F)cccc1Oc1ccc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1170391 | 10653 | None | 0 | Human | Functional | pKi | = | 6.8 | 6.8 | - | 0 | ChEMBL | 489 | 6 | 2 | 4 | 5.8 | O=C(O)c1c(F)cccc1Oc1ccc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
49798347 | 10578 | None | 0 | Human | Functional | pKi | = | 6.8 | 6.8 | - | 0 | ChEMBL | 403 | 6 | 2 | 4 | 4.6 | O=C(O)c1ccccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1169824 | 10578 | None | 0 | Human | Functional | pKi | = | 6.8 | 6.8 | - | 0 | ChEMBL | 403 | 6 | 2 | 4 | 4.6 | O=C(O)c1ccccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2010.04.142 | |||
49798323 | 10792 | None | 0 | Mouse | Functional | pKi | = | 6.8 | 6.8 | - | 0 | ChEMBL | 437 | 6 | 2 | 4 | 5.3 | O=C(O)c1ccccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171760 | 10792 | None | 0 | Mouse | Functional | pKi | = | 6.8 | 6.8 | - | 0 | ChEMBL | 437 | 6 | 2 | 4 | 5.3 | O=C(O)c1ccccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
19430534 | 10776 | None | 0 | Mouse | Functional | pKi | = | 5.8 | 5.8 | - | 0 | ChEMBL | 471 | 6 | 2 | 4 | 5.7 | O=C(O)c1ccccc1Oc1ccc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171586 | 10776 | None | 0 | Mouse | Functional | pKi | = | 5.8 | 5.8 | - | 0 | ChEMBL | 471 | 6 | 2 | 4 | 5.7 | O=C(O)c1ccccc1Oc1ccc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
57396690 | 69142 | None | 0 | Human | Functional | pKi | = | 5.8 | 5.8 | - | 0 | ChEMBL | 582 | 9 | 2 | 6 | 5.9 | O=C(NCCN1CCCCC1)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924010 | 69142 | None | 0 | Human | Functional | pKi | = | 5.8 | 5.8 | - | 0 | ChEMBL | 582 | 9 | 2 | 6 | 5.9 | O=C(NCCN1CCCCC1)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2011.10.038 | |||
57400128 | 69147 | None | 0 | Human | Functional | pKi | = | 7.8 | 7.8 | - | 0 | ChEMBL | 629 | 9 | 2 | 5 | 7.1 | Cc1cc(Oc2ccc(C(=O)NCCN3CCCCC3)cc2)c(NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1Cl | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924015 | 69147 | None | 0 | Human | Functional | pKi | = | 7.8 | 7.8 | - | 0 | ChEMBL | 629 | 9 | 2 | 5 | 7.1 | Cc1cc(Oc2ccc(C(=O)NCCN3CCCCC3)cc2)c(NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1Cl | 10.1016/j.bmcl.2011.10.038 | |||
44296501 | 101841 | None | 0 | Human | Functional | pKi | = | 5.8 | 5.8 | - | 0 | ChEMBL | 472 | 8 | 3 | 2 | 6.6 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)Nc1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL300025 | 101841 | None | 0 | Human | Functional | pKi | = | 5.8 | 5.8 | - | 0 | ChEMBL | 472 | 8 | 3 | 2 | 6.6 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)Nc1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00347-4 | |||
44296501 | 101841 | None | 0 | Human | Functional | pKi | = | 5.8 | 5.8 | - | 0 | ChEMBL | 472 | 8 | 3 | 2 | 6.6 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)Nc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL300025 | 101841 | None | 0 | Human | Functional | pKi | = | 5.8 | 5.8 | - | 0 | ChEMBL | 472 | 8 | 3 | 2 | 6.6 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)Nc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2007.12.072 | |||
44296501 | 101841 | None | 0 | Human | Functional | pKi | = | 5.8 | 5.8 | - | 0 | ChEMBL | 472 | 8 | 3 | 2 | 6.6 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)Nc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL300025 | 101841 | None | 0 | Human | Functional | pKi | = | 5.8 | 5.8 | - | 0 | ChEMBL | 472 | 8 | 3 | 2 | 6.6 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)Nc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2007.12.072 | |||
44296264 | 194703 | None | 0 | Human | Functional | pKi | = | 5.8 | 5.8 | - | 0 | ChEMBL | 471 | 9 | 2 | 2 | 6.6 | CC(C)(C)c1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL53130 | 194703 | None | 0 | Human | Functional | pKi | = | 5.8 | 5.8 | - | 0 | ChEMBL | 471 | 9 | 2 | 2 | 6.6 | CC(C)(C)c1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/s0960-894x(00)00347-4 | |||
44446951 | 94657 | None | 0 | Human | Functional | pKi | = | 5.8 | 5.8 | - | 0 | ChEMBL | 471 | 12 | 2 | 2 | 6.7 | CCCCc1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL252186 | 94657 | None | 0 | Human | Functional | pKi | = | 5.8 | 5.8 | - | 0 | ChEMBL | 471 | 12 | 2 | 2 | 6.7 | CCCCc1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2007.12.072 | |||
44446951 | 94657 | None | 0 | Human | Functional | pKi | = | 5.8 | 5.8 | - | 0 | ChEMBL | 471 | 12 | 2 | 2 | 6.7 | CCCCc1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL252186 | 94657 | None | 0 | Human | Functional | pKi | = | 5.8 | 5.8 | - | 0 | ChEMBL | 471 | 12 | 2 | 2 | 6.7 | CCCCc1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2007.12.072 | |||
49798438 | 10696 | None | 0 | Human | Functional | pKi | = | 7.7 | 7.7 | - | 0 | ChEMBL | 429 | 5 | 1 | 5 | 5.0 | O=S(=O)(Nc1cc(Cl)cnc1Oc1cccnc1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1170722 | 10696 | None | 0 | Human | Functional | pKi | = | 7.7 | 7.7 | - | 0 | ChEMBL | 429 | 5 | 1 | 5 | 5.0 | O=S(=O)(Nc1cc(Cl)cnc1Oc1cccnc1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
49798323 | 10792 | None | 0 | Human | Functional | pKi | = | 7.7 | 7.7 | - | 0 | ChEMBL | 437 | 6 | 2 | 4 | 5.3 | O=C(O)c1ccccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171760 | 10792 | None | 0 | Human | Functional | pKi | = | 7.7 | 7.7 | - | 0 | ChEMBL | 437 | 6 | 2 | 4 | 5.3 | O=C(O)c1ccccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
49798464 | 10632 | None | 0 | Human | Functional | pKi | = | 6.7 | 6.7 | - | 0 | ChEMBL | 430 | 5 | 1 | 6 | 4.4 | O=S(=O)(Nc1cc(Cl)cnc1Oc1cccnn1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1170187 | 10632 | None | 0 | Human | Functional | pKi | = | 6.7 | 6.7 | - | 0 | ChEMBL | 430 | 5 | 1 | 6 | 4.4 | O=S(=O)(Nc1cc(Cl)cnc1Oc1cccnn1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
49798264 | 10791 | None | 0 | Mouse | Functional | pKi | = | 5.7 | 5.7 | - | 0 | ChEMBL | 403 | 6 | 2 | 4 | 4.6 | O=C(O)c1ccccc1Oc1ccccc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171758 | 10791 | None | 0 | Mouse | Functional | pKi | = | 5.7 | 5.7 | - | 0 | ChEMBL | 403 | 6 | 2 | 4 | 4.6 | O=C(O)c1ccccc1Oc1ccccc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
57400129 | 69149 | None | 0 | Human | Functional | pKi | = | 8.7 | 8.7 | - | 0 | ChEMBL | 601 | 9 | 2 | 5 | 6.4 | O=C(NCCN1CCCC1)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924017 | 69149 | None | 0 | Human | Functional | pKi | = | 8.7 | 8.7 | - | 0 | ChEMBL | 601 | 9 | 2 | 5 | 6.4 | O=C(NCCN1CCCC1)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
57400125 | 69136 | None | 0 | Human | Functional | pKi | = | 7.7 | 7.7 | - | 0 | ChEMBL | 582 | 9 | 2 | 6 | 5.9 | O=C(NCCN1CCCCC1)c1ccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924004 | 69136 | None | 0 | Human | Functional | pKi | = | 7.7 | 7.7 | - | 0 | ChEMBL | 582 | 9 | 2 | 6 | 5.9 | O=C(NCCN1CCCCC1)c1ccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
57391450 | 69141 | None | 0 | Human | Functional | pKi | = | 6.7 | 6.7 | - | 0 | ChEMBL | 583 | 9 | 3 | 7 | 4.3 | O=C(NCCN1CCNCC1)c1cccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924009 | 69141 | None | 0 | Human | Functional | pKi | = | 6.7 | 6.7 | - | 0 | ChEMBL | 583 | 9 | 3 | 7 | 4.3 | O=C(NCCN1CCNCC1)c1cccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1 | 10.1016/j.bmcl.2011.10.038 | |||
44296268 | 101898 | None | 0 | Human | Functional | pKi | = | 6.6 | 6.6 | - | 0 | ChEMBL | 513 | 9 | 3 | 3 | 6.7 | Cc1[nH]c2ccc(O)cc2c1C1CCN(CCCCCNC(=O)/C=C/c2ccc(Cl)c(Cl)c2)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL300455 | 101898 | None | 0 | Human | Functional | pKi | = | 6.6 | 6.6 | - | 0 | ChEMBL | 513 | 9 | 3 | 3 | 6.7 | Cc1[nH]c2ccc(O)cc2c1C1CCN(CCCCCNC(=O)/C=C/c2ccc(Cl)c(Cl)c2)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
57393496 | 69153 | None | 0 | Human | Functional | pKi | = | 7.6 | 7.6 | - | 0 | ChEMBL | 629 | 9 | 2 | 5 | 7.1 | Cc1cc(C(=O)NCCN2CCCCC2)ccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924021 | 69153 | None | 0 | Human | Functional | pKi | = | 7.6 | 7.6 | - | 0 | ChEMBL | 629 | 9 | 2 | 5 | 7.1 | Cc1cc(C(=O)NCCN2CCCCC2)ccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.10.038 | |||
57393497 | 69154 | None | 0 | Human | Functional | pKi | = | 7.6 | 7.6 | - | 0 | ChEMBL | 645 | 10 | 2 | 6 | 6.8 | COc1cc(C(=O)NCCN2CCCCC2)ccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924022 | 69154 | None | 0 | Human | Functional | pKi | = | 7.6 | 7.6 | - | 0 | ChEMBL | 645 | 10 | 2 | 6 | 6.8 | COc1cc(C(=O)NCCN2CCCCC2)ccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.10.038 | |||
49798437 | 10562 | None | 0 | Human | Functional | pKi | = | 7.6 | 7.6 | - | 0 | ChEMBL | 515 | 8 | 3 | 6 | 4.4 | O=C(NCCO)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1169660 | 10562 | None | 0 | Human | Functional | pKi | = | 7.6 | 7.6 | - | 0 | ChEMBL | 515 | 8 | 3 | 6 | 4.4 | O=C(NCCO)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
44296155 | 101557 | None | 0 | Human | Functional | pKi | = | 5.6 | 5.6 | - | 0 | ChEMBL | 455 | 7 | 2 | 2 | 5.9 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL297950 | 101557 | None | 0 | Human | Functional | pKi | = | 5.6 | 5.6 | - | 0 | ChEMBL | 455 | 7 | 2 | 2 | 5.9 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
44296155 | 101557 | None | 0 | Human | Functional | pKi | = | 5.6 | 5.6 | - | 0 | ChEMBL | 455 | 7 | 2 | 2 | 5.9 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL297950 | 101557 | None | 0 | Human | Functional | pKi | = | 5.6 | 5.6 | - | 0 | ChEMBL | 455 | 7 | 2 | 2 | 5.9 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
57391449 | 69138 | None | 0 | Human | Functional | pKi | = | 6.6 | 6.6 | - | 0 | ChEMBL | 583 | 9 | 3 | 7 | 4.3 | O=C(NCCN1CCNCC1)c1ccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924006 | 69138 | None | 0 | Human | Functional | pKi | = | 6.6 | 6.6 | - | 0 | ChEMBL | 583 | 9 | 3 | 7 | 4.3 | O=C(NCCN1CCNCC1)c1ccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
49798264 | 10791 | None | 0 | Human | Functional | pKi | = | 6.6 | 6.6 | - | 0 | ChEMBL | 403 | 6 | 2 | 4 | 4.6 | O=C(O)c1ccccc1Oc1ccccc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171758 | 10791 | None | 0 | Human | Functional | pKi | = | 6.6 | 6.6 | - | 0 | ChEMBL | 403 | 6 | 2 | 4 | 4.6 | O=C(O)c1ccccc1Oc1ccccc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
49798292 | 10561 | None | 0 | Mouse | Functional | pKi | = | 6.6 | 6.6 | - | 0 | ChEMBL | 421 | 6 | 2 | 4 | 4.8 | O=C(O)c1ccccc1Oc1ccc(F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1169653 | 10561 | None | 0 | Mouse | Functional | pKi | = | 6.6 | 6.6 | - | 0 | ChEMBL | 421 | 6 | 2 | 4 | 4.8 | O=C(O)c1ccccc1Oc1ccc(F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
49798265 | 10732 | None | 0 | Mouse | Functional | pKi | = | 6.6 | 6.6 | - | 0 | ChEMBL | 489 | 6 | 2 | 4 | 5.8 | O=C(O)c1ccccc1Oc1c(F)cc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171006 | 10732 | None | 0 | Mouse | Functional | pKi | = | 6.6 | 6.6 | - | 0 | ChEMBL | 489 | 6 | 2 | 4 | 5.8 | O=C(O)c1ccccc1Oc1c(F)cc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
57391450 | 69141 | None | 0 | Human | Functional | pKi | = | 5.6 | 5.6 | - | 0 | ChEMBL | 583 | 9 | 3 | 7 | 4.3 | O=C(NCCN1CCNCC1)c1cccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924009 | 69141 | None | 0 | Human | Functional | pKi | = | 5.6 | 5.6 | - | 0 | ChEMBL | 583 | 9 | 3 | 7 | 4.3 | O=C(NCCN1CCNCC1)c1cccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1 | 10.1016/j.bmcl.2011.10.038 | |||
44296155 | 101557 | None | 0 | Human | Functional | pKi | = | 5.6 | 5.6 | - | 0 | ChEMBL | 455 | 7 | 2 | 2 | 5.9 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL297950 | 101557 | None | 0 | Human | Functional | pKi | = | 5.6 | 5.6 | - | 0 | ChEMBL | 455 | 7 | 2 | 2 | 5.9 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
57394939 | 69143 | None | 0 | Human | Functional | pKi | = | 5.6 | 5.6 | - | 0 | ChEMBL | 568 | 9 | 2 | 6 | 5.5 | O=C(NCCN1CCCC1)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924011 | 69143 | None | 0 | Human | Functional | pKi | = | 5.6 | 5.6 | - | 0 | ChEMBL | 568 | 9 | 2 | 6 | 5.5 | O=C(NCCN1CCCC1)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2011.10.038 | |||
44296269 | 194847 | None | 0 | Human | Functional | pKi | = | 5.6 | 5.6 | - | 0 | ChEMBL | 440 | 9 | 2 | 3 | 5.2 | N#Cc1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL53557 | 194847 | None | 0 | Human | Functional | pKi | = | 5.6 | 5.6 | - | 0 | ChEMBL | 440 | 9 | 2 | 3 | 5.2 | N#Cc1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/s0960-894x(00)00347-4 | |||
44296269 | 194847 | None | 0 | Human | Functional | pKi | = | 5.6 | 5.6 | - | 0 | ChEMBL | 440 | 9 | 2 | 3 | 5.2 | N#Cc1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL53557 | 194847 | None | 0 | Human | Functional | pKi | = | 5.6 | 5.6 | - | 0 | ChEMBL | 440 | 9 | 2 | 3 | 5.2 | N#Cc1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2007.12.072 | |||
44296287 | 101742 | None | 0 | Human | Functional | pKi | = | 5.5 | 5.5 | - | 0 | ChEMBL | 472 | 10 | 3 | 3 | 5.3 | CC(=O)Nc1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL299379 | 101742 | None | 0 | Human | Functional | pKi | = | 5.5 | 5.5 | - | 0 | ChEMBL | 472 | 10 | 3 | 3 | 5.3 | CC(=O)Nc1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/s0960-894x(00)00347-4 | |||
57400127 | 69146 | None | 0 | Human | Functional | pKi | = | 8.5 | 8.5 | - | 0 | ChEMBL | 616 | 9 | 2 | 6 | 6.2 | O=C(NCCN1CCCCC1)c1ccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924014 | 69146 | None | 0 | Human | Functional | pKi | = | 8.5 | 8.5 | - | 0 | ChEMBL | 616 | 9 | 2 | 6 | 6.2 | O=C(NCCN1CCCCC1)c1ccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
49798436 | 10708 | None | 0 | Human | Functional | pKi | = | 8.5 | 8.5 | - | 0 | ChEMBL | 472 | 6 | 2 | 5 | 5.3 | O=C(O)c1ccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1170829 | 10708 | None | 0 | Human | Functional | pKi | = | 8.5 | 8.5 | - | 0 | ChEMBL | 472 | 6 | 2 | 5 | 5.3 | O=C(O)c1ccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
49798349 | 10795 | None | 0 | Human | Functional | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 471 | 6 | 2 | 4 | 5.9 | O=C(O)c1ccccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171786 | 10795 | None | 0 | Human | Functional | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 471 | 6 | 2 | 4 | 5.9 | O=C(O)c1ccccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
49798399 | 10704 | None | 0 | Human | Functional | pKi | = | 7.5 | 7.5 | - | 0 | ChEMBL | 438 | 6 | 2 | 5 | 4.7 | O=C(O)c1ccccc1Oc1ncccc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1170801 | 10704 | None | 0 | Human | Functional | pKi | = | 7.5 | 7.5 | - | 0 | ChEMBL | 438 | 6 | 2 | 5 | 4.7 | O=C(O)c1ccccc1Oc1ncccc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
49798265 | 10732 | None | 0 | Human | Functional | pKi | = | 7.5 | 7.5 | - | 0 | ChEMBL | 489 | 6 | 2 | 4 | 5.8 | O=C(O)c1ccccc1Oc1c(F)cc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171006 | 10732 | None | 0 | Human | Functional | pKi | = | 7.5 | 7.5 | - | 0 | ChEMBL | 489 | 6 | 2 | 4 | 5.8 | O=C(O)c1ccccc1Oc1c(F)cc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
25110660 | 94849 | None | 0 | Human | Functional | pKi | = | 6.5 | 6.5 | - | 0 | ChEMBL | 525 | 6 | 3 | 3 | 6.7 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@H](CN2CCC(c3c[nH]c4ccc(O)cc34)CC2)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL253424 | 94849 | None | 0 | Human | Functional | pKi | = | 6.5 | 6.5 | - | 0 | ChEMBL | 525 | 6 | 3 | 3 | 6.7 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@H](CN2CCC(c3c[nH]c4ccc(O)cc34)CC2)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
25110660 | 94849 | None | 0 | Human | Functional | pKi | = | 6.5 | 6.5 | - | 0 | ChEMBL | 525 | 6 | 3 | 3 | 6.7 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@H](CN2CCC(c3c[nH]c4ccc(O)cc34)CC2)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL253424 | 94849 | None | 0 | Human | Functional | pKi | = | 6.5 | 6.5 | - | 0 | ChEMBL | 525 | 6 | 3 | 3 | 6.7 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@H](CN2CCC(c3c[nH]c4ccc(O)cc34)CC2)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
44296630 | 101420 | None | 0 | Human | Functional | pKi | = | 6.5 | 6.5 | - | 0 | ChEMBL | 493 | 9 | 2 | 2 | 6.1 | O=C(/C=C/c1ccc(Br)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL297033 | 101420 | None | 0 | Human | Functional | pKi | = | 6.5 | 6.5 | - | 0 | ChEMBL | 493 | 9 | 2 | 2 | 6.1 | O=C(/C=C/c1ccc(Br)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
44296630 | 101420 | None | 0 | Human | Functional | pKi | = | 6.5 | 6.5 | - | 0 | ChEMBL | 493 | 9 | 2 | 2 | 6.1 | O=C(/C=C/c1ccc(Br)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL297033 | 101420 | None | 0 | Human | Functional | pKi | = | 6.5 | 6.5 | - | 0 | ChEMBL | 493 | 9 | 2 | 2 | 6.1 | O=C(/C=C/c1ccc(Br)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
44296630 | 101420 | None | 0 | Human | Functional | pKi | = | 6.5 | 6.5 | - | 0 | ChEMBL | 493 | 9 | 2 | 2 | 6.1 | O=C(/C=C/c1ccc(Br)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL297033 | 101420 | None | 0 | Human | Functional | pKi | = | 6.5 | 6.5 | - | 0 | ChEMBL | 493 | 9 | 2 | 2 | 6.1 | O=C(/C=C/c1ccc(Br)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
44296366 | 189535 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCCCN1CCC(c2c[nH]c3cc(O)ccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL51332 | 189535 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCCCN1CCC(c2c[nH]c3cc(O)ccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
44296384 | 196220 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCCCN1CCC(c2c[nH]c3cccc(O)c23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL54192 | 196220 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCCCN1CCC(c2c[nH]c3cccc(O)c23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
49798292 | 10561 | None | 0 | Human | Functional | pKi | = | 7.4 | 7.4 | - | 0 | ChEMBL | 421 | 6 | 2 | 4 | 4.8 | O=C(O)c1ccccc1Oc1ccc(F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1169653 | 10561 | None | 0 | Human | Functional | pKi | = | 7.4 | 7.4 | - | 0 | ChEMBL | 421 | 6 | 2 | 4 | 4.8 | O=C(O)c1ccccc1Oc1ccc(F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
49798264 | 10791 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 403 | 6 | 2 | 4 | 4.6 | O=C(O)c1ccccc1Oc1ccccc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171758 | 10791 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 403 | 6 | 2 | 4 | 4.6 | O=C(O)c1ccccc1Oc1ccccc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
49798264 | 10791 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 403 | 6 | 2 | 4 | 4.6 | O=C(O)c1ccccc1Oc1ccccc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171758 | 10791 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 403 | 6 | 2 | 4 | 4.6 | O=C(O)c1ccccc1Oc1ccccc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
49798397 | 10702 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 439 | 6 | 2 | 6 | 4.1 | O=C(O)c1ccccc1Oc1ncncc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1170799 | 10702 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 439 | 6 | 2 | 6 | 4.1 | O=C(O)c1ccccc1Oc1ncncc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
49798351 | 10797 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 341 | 5 | 2 | 4 | 3.2 | CS(=O)(=O)Nc1cc(Cl)ccc1Oc1ccccc1C(=O)O | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171788 | 10797 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 341 | 5 | 2 | 4 | 3.2 | CS(=O)(=O)Nc1cc(Cl)ccc1Oc1ccccc1C(=O)O | 10.1016/j.bmcl.2010.04.142 | |||
49798325 | 10810 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 437 | 6 | 2 | 4 | 5.3 | O=C(O)c1ccccc1Oc1c(Cl)cccc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171938 | 10810 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 437 | 6 | 2 | 4 | 5.3 | O=C(O)c1ccccc1Oc1c(Cl)cccc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
57400420 | 69151 | None | 0 | Human | Functional | pKi | = | 8.4 | 8.4 | - | 0 | ChEMBL | 631 | 10 | 2 | 6 | 6.4 | COc1cc(Oc2ccc(C(=O)NCCN3CCCC3)cc2)c(NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1Cl | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924019 | 69151 | None | 0 | Human | Functional | pKi | = | 8.4 | 8.4 | - | 0 | ChEMBL | 631 | 10 | 2 | 6 | 6.4 | COc1cc(Oc2ccc(C(=O)NCCN3CCCC3)cc2)c(NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1Cl | 10.1016/j.bmcl.2011.10.038 | |||
57391449 | 69138 | None | 0 | Human | Functional | pKi | = | 7.4 | 7.4 | - | 0 | ChEMBL | 583 | 9 | 3 | 7 | 4.3 | O=C(NCCN1CCNCC1)c1ccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924006 | 69138 | None | 0 | Human | Functional | pKi | = | 7.4 | 7.4 | - | 0 | ChEMBL | 583 | 9 | 3 | 7 | 4.3 | O=C(NCCN1CCNCC1)c1ccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
44296087 | 101710 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 483 | 9 | 2 | 2 | 6.7 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL299153 | 101710 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 483 | 9 | 2 | 2 | 6.7 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
44296087 | 101710 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 483 | 9 | 2 | 2 | 6.7 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL299153 | 101710 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 483 | 9 | 2 | 2 | 6.7 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
44296344 | 162649 | None | 0 | Human | Functional | pKi | = | 5.4 | 5.4 | - | 0 | ChEMBL | 513 | 9 | 2 | 4 | 6.4 | Cn1cc(C2CCN(CCCCCNC(=O)/C=C/c3ccc(Cl)c(Cl)c3)CC2)c2cc(O)ccc21 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL416833 | 162649 | None | 0 | Human | Functional | pKi | = | 5.4 | 5.4 | - | 0 | ChEMBL | 513 | 9 | 2 | 4 | 6.4 | Cn1cc(C2CCN(CCCCCNC(=O)/C=C/c3ccc(Cl)c(Cl)c3)CC2)c2cc(O)ccc21 | 10.1016/s0960-894x(00)00347-4 | |||
44296087 | 101710 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 483 | 9 | 2 | 2 | 6.7 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL299153 | 101710 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 483 | 9 | 2 | 2 | 6.7 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
44296469 | 194870 | None | 0 | Human | Functional | pKi | = | 5.4 | 5.4 | - | 0 | ChEMBL | 471 | 9 | 2 | 2 | 6.2 | O=C(Cc1ccc(Cl)c(Cl)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL53779 | 194870 | None | 0 | Human | Functional | pKi | = | 5.4 | 5.4 | - | 0 | ChEMBL | 471 | 9 | 2 | 2 | 6.2 | O=C(Cc1ccc(Cl)c(Cl)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
44296409 | 194938 | None | 0 | Human | Functional | pKi | = | 5.4 | 5.4 | - | 0 | ChEMBL | 449 | 9 | 2 | 2 | 6.0 | O=C(/C=C/c1ccccc1Cl)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL53930 | 194938 | None | 0 | Human | Functional | pKi | = | 5.4 | 5.4 | - | 0 | ChEMBL | 449 | 9 | 2 | 2 | 6.0 | O=C(/C=C/c1ccccc1Cl)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
44296469 | 194870 | None | 0 | Human | Functional | pKi | = | 5.4 | 5.4 | - | 0 | ChEMBL | 471 | 9 | 2 | 2 | 6.2 | O=C(Cc1ccc(Cl)c(Cl)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL53779 | 194870 | None | 0 | Human | Functional | pKi | = | 5.4 | 5.4 | - | 0 | ChEMBL | 471 | 9 | 2 | 2 | 6.2 | O=C(Cc1ccc(Cl)c(Cl)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
44296409 | 194938 | None | 0 | Human | Functional | pKi | = | 5.4 | 5.4 | - | 0 | ChEMBL | 449 | 9 | 2 | 2 | 6.0 | O=C(/C=C/c1ccccc1Cl)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL53930 | 194938 | None | 0 | Human | Functional | pKi | = | 5.4 | 5.4 | - | 0 | ChEMBL | 449 | 9 | 2 | 2 | 6.0 | O=C(/C=C/c1ccccc1Cl)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
44296469 | 194870 | None | 0 | Human | Functional | pKi | = | 5.4 | 5.4 | - | 0 | ChEMBL | 471 | 9 | 2 | 2 | 6.2 | O=C(Cc1ccc(Cl)c(Cl)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL53779 | 194870 | None | 0 | Human | Functional | pKi | = | 5.4 | 5.4 | - | 0 | ChEMBL | 471 | 9 | 2 | 2 | 6.2 | O=C(Cc1ccc(Cl)c(Cl)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
44296409 | 194938 | None | 0 | Human | Functional | pKi | = | 5.4 | 5.4 | - | 0 | ChEMBL | 449 | 9 | 2 | 2 | 6.0 | O=C(/C=C/c1ccccc1Cl)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL53930 | 194938 | None | 0 | Human | Functional | pKi | = | 5.4 | 5.4 | - | 0 | ChEMBL | 449 | 9 | 2 | 2 | 6.0 | O=C(/C=C/c1ccccc1Cl)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
44296629 | 101734 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 541 | 9 | 2 | 2 | 6.0 | O=C(/C=C/c1ccc(I)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL299322 | 101734 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 541 | 9 | 2 | 2 | 6.0 | O=C(/C=C/c1ccc(I)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
44296629 | 101734 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 541 | 9 | 2 | 2 | 6.0 | O=C(/C=C/c1ccc(I)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL299322 | 101734 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 541 | 9 | 2 | 2 | 6.0 | O=C(/C=C/c1ccc(I)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
44296629 | 101734 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 541 | 9 | 2 | 2 | 6.0 | O=C(/C=C/c1ccc(I)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL299322 | 101734 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 541 | 9 | 2 | 2 | 6.0 | O=C(/C=C/c1ccc(I)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
49798350 | 10796 | None | 0 | Human | Functional | pKi | = | 8.3 | 8.3 | - | 0 | ChEMBL | 443 | 6 | 2 | 5 | 5.3 | O=C(O)c1ccccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)s1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171787 | 10796 | None | 0 | Human | Functional | pKi | = | 8.3 | 8.3 | - | 0 | ChEMBL | 443 | 6 | 2 | 5 | 5.3 | O=C(O)c1ccccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)s1 | 10.1016/j.bmcl.2010.04.142 | |||
10436045 | 3516 | None | 4 | Human | Functional | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(00)00347-4 | |||
782 | 3516 | None | 4 | Human | Functional | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL432713 | 3516 | None | 4 | Human | Functional | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(00)00347-4 | |||
10436045 | 3516 | None | 4 | Human | Functional | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmcl.2007.12.072 | |||
782 | 3516 | None | 4 | Human | Functional | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL432713 | 3516 | None | 4 | Human | Functional | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmcl.2007.12.072 | |||
49798398 | 10703 | None | 0 | Human | Functional | pKi | = | 7.3 | 7.3 | - | 0 | ChEMBL | 438 | 6 | 2 | 5 | 4.7 | O=C(O)c1ccccc1Oc1cnccc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1170800 | 10703 | None | 0 | Human | Functional | pKi | = | 7.3 | 7.3 | - | 0 | ChEMBL | 438 | 6 | 2 | 5 | 4.7 | O=C(O)c1ccccc1Oc1cnccc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
49798489 | 10737 | None | 0 | Human | Functional | pKi | = | 7.3 | 7.3 | - | 0 | ChEMBL | 434 | 5 | 1 | 6 | 4.6 | Cc1ncccc1Oc1ncc(C#N)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171035 | 10737 | None | 0 | Human | Functional | pKi | = | 7.3 | 7.3 | - | 0 | ChEMBL | 434 | 5 | 1 | 6 | 4.6 | Cc1ncccc1Oc1ncc(C#N)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
10436045 | 3516 | None | 4 | Human | Functional | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmcl.2007.12.072 | |||
782 | 3516 | None | 4 | Human | Functional | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL432713 | 3516 | None | 4 | Human | Functional | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmcl.2007.12.072 | |||
49798325 | 10810 | None | 0 | Mouse | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 437 | 6 | 2 | 4 | 5.3 | O=C(O)c1ccccc1Oc1c(Cl)cccc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171938 | 10810 | None | 0 | Mouse | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 437 | 6 | 2 | 4 | 5.3 | O=C(O)c1ccccc1Oc1c(Cl)cccc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
25110679 | 168255 | None | 0 | Human | Functional | pKi | = | 5.3 | 5.3 | - | 0 | ChEMBL | 457 | 8 | 2 | 2 | 6.3 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL433081 | 168255 | None | 0 | Human | Functional | pKi | = | 5.3 | 5.3 | - | 0 | ChEMBL | 457 | 8 | 2 | 2 | 6.3 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(00)00347-4 | |||
25110679 | 168255 | None | 0 | Human | Functional | pKi | = | 5.3 | 5.3 | - | 0 | ChEMBL | 457 | 8 | 2 | 2 | 6.3 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL433081 | 168255 | None | 0 | Human | Functional | pKi | = | 5.3 | 5.3 | - | 0 | ChEMBL | 457 | 8 | 2 | 2 | 6.3 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2007.12.072 | |||
25110679 | 168255 | None | 0 | Human | Functional | pKi | = | 5.3 | 5.3 | - | 0 | ChEMBL | 457 | 8 | 2 | 2 | 6.3 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL433081 | 168255 | None | 0 | Human | Functional | pKi | = | 5.3 | 5.3 | - | 0 | ChEMBL | 457 | 8 | 2 | 2 | 6.3 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2007.12.072 | |||
44296428 | 101816 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 449 | 9 | 2 | 2 | 6.0 | O=C(/C=C/c1ccc(Cl)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL299855 | 101816 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 449 | 9 | 2 | 2 | 6.0 | O=C(/C=C/c1ccc(Cl)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
44296428 | 101816 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 449 | 9 | 2 | 2 | 6.0 | O=C(/C=C/c1ccc(Cl)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL299855 | 101816 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 449 | 9 | 2 | 2 | 6.0 | O=C(/C=C/c1ccc(Cl)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
44296428 | 101816 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 449 | 9 | 2 | 2 | 6.0 | O=C(/C=C/c1ccc(Cl)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL299855 | 101816 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 449 | 9 | 2 | 2 | 6.0 | O=C(/C=C/c1ccc(Cl)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
25110564 | 194885 | None | 0 | Human | Functional | pKi | = | 5.3 | 5.3 | - | 0 | ChEMBL | 465 | 9 | 2 | 2 | 6.6 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)c1ccc(-c2ccccc2)cc1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL53819 | 194885 | None | 0 | Human | Functional | pKi | = | 5.3 | 5.3 | - | 0 | ChEMBL | 465 | 9 | 2 | 2 | 6.6 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)c1ccc(-c2ccccc2)cc1 | 10.1016/s0960-894x(00)00347-4 | |||
25110564 | 194885 | None | 0 | Human | Functional | pKi | = | 5.3 | 5.3 | - | 0 | ChEMBL | 465 | 9 | 2 | 2 | 6.6 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)c1ccc(-c2ccccc2)cc1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL53819 | 194885 | None | 0 | Human | Functional | pKi | = | 5.3 | 5.3 | - | 0 | ChEMBL | 465 | 9 | 2 | 2 | 6.6 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)c1ccc(-c2ccccc2)cc1 | 10.1016/s0960-894x(00)00347-4 | |||
25110564 | 194885 | None | 0 | Human | Functional | pKi | = | 5.3 | 5.3 | - | 0 | ChEMBL | 465 | 9 | 2 | 2 | 6.6 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)c1ccc(-c2ccccc2)cc1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL53819 | 194885 | None | 0 | Human | Functional | pKi | = | 5.3 | 5.3 | - | 0 | ChEMBL | 465 | 9 | 2 | 2 | 6.6 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)c1ccc(-c2ccccc2)cc1 | 10.1016/j.bmcl.2007.12.072 | |||
25110564 | 194885 | None | 0 | Human | Functional | pKi | = | 5.3 | 5.3 | - | 0 | ChEMBL | 465 | 9 | 2 | 2 | 6.6 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)c1ccc(-c2ccccc2)cc1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL53819 | 194885 | None | 0 | Human | Functional | pKi | = | 5.3 | 5.3 | - | 0 | ChEMBL | 465 | 9 | 2 | 2 | 6.6 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)c1ccc(-c2ccccc2)cc1 | 10.1016/j.bmcl.2007.12.072 | |||
44296398 | 188397 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 429 | 9 | 2 | 2 | 5.7 | Cc1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL50025 | 188397 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 429 | 9 | 2 | 2 | 5.7 | Cc1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/s0960-894x(00)00347-4 | |||
44296398 | 188397 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 429 | 9 | 2 | 2 | 5.7 | Cc1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL50025 | 188397 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 429 | 9 | 2 | 2 | 5.7 | Cc1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2007.12.072 | |||
44296410 | 194831 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 449 | 9 | 2 | 2 | 6.0 | O=C(/C=C/c1cccc(Cl)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL53476 | 194831 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 449 | 9 | 2 | 2 | 6.0 | O=C(/C=C/c1cccc(Cl)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
44296410 | 194831 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 449 | 9 | 2 | 2 | 6.0 | O=C(/C=C/c1cccc(Cl)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL53476 | 194831 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 449 | 9 | 2 | 2 | 6.0 | O=C(/C=C/c1cccc(Cl)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
44296398 | 188397 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 429 | 9 | 2 | 2 | 5.7 | Cc1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL50025 | 188397 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 429 | 9 | 2 | 2 | 5.7 | Cc1ccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)cc1 | 10.1016/j.bmcl.2007.12.072 | |||
44296410 | 194831 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 449 | 9 | 2 | 2 | 6.0 | O=C(/C=C/c1cccc(Cl)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL53476 | 194831 | None | 0 | Human | Functional | pKi | = | 6.3 | 6.3 | - | 0 | ChEMBL | 449 | 9 | 2 | 2 | 6.0 | O=C(/C=C/c1cccc(Cl)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
10940216 | 191317 | None | 0 | Human | Functional | pKi | = | 6.2 | 6.2 | - | 0 | ChEMBL | 513 | 10 | 2 | 3 | 6.7 | COc1ccc2[nH]cc(C3CCN(CCCCCNC(=O)/C=C/c4ccc(Cl)c(Cl)c4)CC3)c2c1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL51895 | 191317 | None | 0 | Human | Functional | pKi | = | 6.2 | 6.2 | - | 0 | ChEMBL | 513 | 10 | 2 | 3 | 6.7 | COc1ccc2[nH]cc(C3CCN(CCCCCNC(=O)/C=C/c4ccc(Cl)c(Cl)c4)CC3)c2c1 | 10.1016/s0960-894x(00)00347-4 | |||
44296077 | 101939 | None | 0 | Human | Functional | pKi | = | 5.2 | 5.2 | - | 0 | ChEMBL | 485 | 10 | 2 | 2 | 6.6 | O=C(CCc1ccc(Cl)c(Cl)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL300744 | 101939 | None | 0 | Human | Functional | pKi | = | 5.2 | 5.2 | - | 0 | ChEMBL | 485 | 10 | 2 | 2 | 6.6 | O=C(CCc1ccc(Cl)c(Cl)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
44296077 | 101939 | None | 0 | Human | Functional | pKi | = | 5.2 | 5.2 | - | 0 | ChEMBL | 485 | 10 | 2 | 2 | 6.6 | O=C(CCc1ccc(Cl)c(Cl)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL300744 | 101939 | None | 0 | Human | Functional | pKi | = | 5.2 | 5.2 | - | 0 | ChEMBL | 485 | 10 | 2 | 2 | 6.6 | O=C(CCc1ccc(Cl)c(Cl)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
44180522 | 69156 | None | 0 | Human | Functional | pKi | = | 8.2 | 8.2 | - | 0 | ChEMBL | 631 | 10 | 2 | 6 | 6.4 | COc1cc(C(=O)NCCN2CCCC2)ccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924024 | 69156 | None | 0 | Human | Functional | pKi | = | 8.2 | 8.2 | - | 0 | ChEMBL | 631 | 10 | 2 | 6 | 6.4 | COc1cc(C(=O)NCCN2CCCC2)ccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.10.038 | |||
57393219 | 69144 | None | 0 | Human | Functional | pKi | = | 7.2 | 7.2 | - | 0 | ChEMBL | 581 | 9 | 2 | 5 | 6.5 | O=C(NCCN1CCCCC1)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924012 | 69144 | None | 0 | Human | Functional | pKi | = | 7.2 | 7.2 | - | 0 | ChEMBL | 581 | 9 | 2 | 5 | 6.5 | O=C(NCCN1CCCCC1)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
57393495 | 69152 | None | 0 | Human | Functional | pKi | = | 7.2 | 7.2 | - | 0 | ChEMBL | 637 | 9 | 2 | 5 | 6.7 | O=C(NCCN1CCC(F)(F)C1)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924020 | 69152 | None | 0 | Human | Functional | pKi | = | 7.2 | 7.2 | - | 0 | ChEMBL | 637 | 9 | 2 | 5 | 6.7 | O=C(NCCN1CCC(F)(F)C1)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
57400126 | 69137 | None | 0 | Human | Functional | pKi | = | 7.2 | 7.2 | - | 0 | ChEMBL | 568 | 9 | 2 | 6 | 5.5 | O=C(NCCN1CCCC1)c1ccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924005 | 69137 | None | 0 | Human | Functional | pKi | = | 7.2 | 7.2 | - | 0 | ChEMBL | 568 | 9 | 2 | 6 | 5.5 | O=C(NCCN1CCCC1)c1ccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1016/j.bmcl.2011.10.038 | |||
49798265 | 10732 | None | 0 | Human | Functional | pKi | = | 7.2 | 7.2 | - | 0 | ChEMBL | 489 | 6 | 2 | 4 | 5.8 | O=C(O)c1ccccc1Oc1c(F)cc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171006 | 10732 | None | 0 | Human | Functional | pKi | = | 7.2 | 7.2 | - | 0 | ChEMBL | 489 | 6 | 2 | 4 | 5.8 | O=C(O)c1ccccc1Oc1c(F)cc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
49798291 | 10560 | None | 0 | Human | Functional | pKi | = | 7.2 | 7.2 | - | 0 | ChEMBL | 428 | 6 | 2 | 5 | 4.5 | N#Cc1ccc(Oc2ccccc2C(=O)O)c(NS(=O)(=O)c2ccc(Cl)cc2)c1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1169652 | 10560 | None | 0 | Human | Functional | pKi | = | 7.2 | 7.2 | - | 0 | ChEMBL | 428 | 6 | 2 | 5 | 4.5 | N#Cc1ccc(Oc2ccccc2C(=O)O)c(NS(=O)(=O)c2ccc(Cl)cc2)c1 | 10.1016/j.bmcl.2010.04.142 | |||
49798326 | 10750 | None | 0 | Human | Functional | pKi | = | 6.2 | 6.2 | - | 0 | ChEMBL | 417 | 6 | 2 | 4 | 4.9 | Cc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)c(Oc2ccccc2C(=O)O)c1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171207 | 10750 | None | 0 | Human | Functional | pKi | = | 6.2 | 6.2 | - | 0 | ChEMBL | 417 | 6 | 2 | 4 | 4.9 | Cc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)c(Oc2ccccc2C(=O)O)c1 | 10.1016/j.bmcl.2010.04.142 | |||
49798326 | 10750 | None | 0 | Mouse | Functional | pKi | = | 6.2 | 6.2 | - | 0 | ChEMBL | 417 | 6 | 2 | 4 | 4.9 | Cc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)c(Oc2ccccc2C(=O)O)c1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171207 | 10750 | None | 0 | Mouse | Functional | pKi | = | 6.2 | 6.2 | - | 0 | ChEMBL | 417 | 6 | 2 | 4 | 4.9 | Cc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)c(Oc2ccccc2C(=O)O)c1 | 10.1016/j.bmcl.2010.04.142 | |||
44296309 | 188735 | None | 0 | Human | Functional | pKi | = | 5.2 | 5.2 | - | 0 | ChEMBL | 431 | 9 | 3 | 3 | 5.1 | O=C(/C=C/c1ccc(O)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL50301 | 188735 | None | 0 | Human | Functional | pKi | = | 5.2 | 5.2 | - | 0 | ChEMBL | 431 | 9 | 3 | 3 | 5.1 | O=C(/C=C/c1ccc(O)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
44296309 | 188735 | None | 0 | Human | Functional | pKi | = | 5.2 | 5.2 | - | 0 | ChEMBL | 431 | 9 | 3 | 3 | 5.1 | O=C(/C=C/c1ccc(O)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL50301 | 188735 | None | 0 | Human | Functional | pKi | = | 5.2 | 5.2 | - | 0 | ChEMBL | 431 | 9 | 3 | 3 | 5.1 | O=C(/C=C/c1ccc(O)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
44296309 | 188735 | None | 0 | Human | Functional | pKi | = | 5.2 | 5.2 | - | 0 | ChEMBL | 431 | 9 | 3 | 3 | 5.1 | O=C(/C=C/c1ccc(O)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL50301 | 188735 | None | 0 | Human | Functional | pKi | = | 5.2 | 5.2 | - | 0 | ChEMBL | 431 | 9 | 3 | 3 | 5.1 | O=C(/C=C/c1ccc(O)cc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
9870980 | 206743 | None | 0 | Human | Functional | pKi | = | 6.2 | 6.2 | - | 0 | ChEMBL | 509 | 6 | 2 | 2 | 7.0 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@H](CN2CCC(c3c[nH]c4ccccc34)CC2)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL71297 | 206743 | None | 0 | Human | Functional | pKi | = | 6.2 | 6.2 | - | 0 | ChEMBL | 509 | 6 | 2 | 2 | 7.0 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@H](CN2CCC(c3c[nH]c4ccccc34)CC2)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
57394939 | 69143 | None | 0 | Human | Functional | pKi | = | 6.2 | 6.2 | - | 0 | ChEMBL | 568 | 9 | 2 | 6 | 5.5 | O=C(NCCN1CCCC1)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924011 | 69143 | None | 0 | Human | Functional | pKi | = | 6.2 | 6.2 | - | 0 | ChEMBL | 568 | 9 | 2 | 6 | 5.5 | O=C(NCCN1CCCC1)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2011.10.038 | |||
9870980 | 206743 | None | 0 | Human | Functional | pKi | = | 6.2 | 6.2 | - | 0 | ChEMBL | 509 | 6 | 2 | 2 | 7.0 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@H](CN2CCC(c3c[nH]c4ccccc34)CC2)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL71297 | 206743 | None | 0 | Human | Functional | pKi | = | 6.2 | 6.2 | - | 0 | ChEMBL | 509 | 6 | 2 | 2 | 7.0 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@H](CN2CCC(c3c[nH]c4ccccc34)CC2)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
44296154 | 189263 | None | 0 | Human | Functional | pKi | = | 6.2 | 6.2 | - | 0 | ChEMBL | 469 | 8 | 2 | 2 | 6.3 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL51094 | 189263 | None | 0 | Human | Functional | pKi | = | 6.2 | 6.2 | - | 0 | ChEMBL | 469 | 8 | 2 | 2 | 6.3 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
44296154 | 189263 | None | 0 | Human | Functional | pKi | = | 6.2 | 6.2 | - | 0 | ChEMBL | 469 | 8 | 2 | 2 | 6.3 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL51094 | 189263 | None | 0 | Human | Functional | pKi | = | 6.2 | 6.2 | - | 0 | ChEMBL | 469 | 8 | 2 | 2 | 6.3 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
44296154 | 189263 | None | 0 | Human | Functional | pKi | = | 6.2 | 6.2 | - | 0 | ChEMBL | 469 | 8 | 2 | 2 | 6.3 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL51094 | 189263 | None | 0 | Human | Functional | pKi | = | 6.2 | 6.2 | - | 0 | ChEMBL | 469 | 8 | 2 | 2 | 6.3 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
49798348 | 10779 | None | 0 | Human | Functional | pKi | = | 8.1 | 8.1 | - | 0 | ChEMBL | 437 | 6 | 2 | 4 | 5.3 | O=C(O)c1ccccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1cccc(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171614 | 10779 | None | 0 | Human | Functional | pKi | = | 8.1 | 8.1 | - | 0 | ChEMBL | 437 | 6 | 2 | 4 | 5.3 | O=C(O)c1ccccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1cccc(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
25110678 | 194655 | None | 0 | Human | Functional | pKi | = | 5.2 | 5.2 | - | 0 | ChEMBL | 467 | 8 | 2 | 2 | 5.7 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL52956 | 194655 | None | 0 | Human | Functional | pKi | = | 5.2 | 5.2 | - | 0 | ChEMBL | 467 | 8 | 2 | 2 | 5.7 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1 | 10.1016/s0960-894x(00)00347-4 | |||
25110678 | 194655 | None | 0 | Human | Functional | pKi | = | 5.2 | 5.2 | - | 0 | ChEMBL | 467 | 8 | 2 | 2 | 5.7 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL52956 | 194655 | None | 0 | Human | Functional | pKi | = | 5.2 | 5.2 | - | 0 | ChEMBL | 467 | 8 | 2 | 2 | 5.7 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1 | 10.1016/j.bmcl.2007.12.072 | |||
25110678 | 194655 | None | 0 | Human | Functional | pKi | = | 5.1 | 5.1 | - | 0 | ChEMBL | 467 | 8 | 2 | 2 | 5.7 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL52956 | 194655 | None | 0 | Human | Functional | pKi | = | 5.1 | 5.1 | - | 0 | ChEMBL | 467 | 8 | 2 | 2 | 5.7 | O=C(NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1 | 10.1016/j.bmcl.2007.12.072 | |||
44296137 | 101631 | None | 0 | Human | Functional | pKi | = | 7.1 | 7.1 | - | 0 | ChEMBL | 576 | 11 | 3 | 4 | 6.0 | CS(=O)(=O)Nc1ccc2[nH]cc(C3CCN(CCCCCNC(=O)/C=C/c4ccc(Cl)c(Cl)c4)CC3)c2c1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL298562 | 101631 | None | 0 | Human | Functional | pKi | = | 7.1 | 7.1 | - | 0 | ChEMBL | 576 | 11 | 3 | 4 | 6.0 | CS(=O)(=O)Nc1ccc2[nH]cc(C3CCN(CCCCCNC(=O)/C=C/c4ccc(Cl)c(Cl)c4)CC3)c2c1 | 10.1016/s0960-894x(00)00347-4 | |||
25110660 | 154962 | None | 0 | Human | Functional | pKi | = | 7.1 | 7.1 | - | 0 | ChEMBL | 525 | 6 | 3 | 3 | 6.7 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@@H](CN2CCC(c3c[nH]c4ccc(O)cc34)CC2)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL400698 | 154962 | None | 0 | Human | Functional | pKi | = | 7.1 | 7.1 | - | 0 | ChEMBL | 525 | 6 | 3 | 3 | 6.7 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@@H](CN2CCC(c3c[nH]c4ccc(O)cc34)CC2)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
57393218 | 69139 | None | 0 | Human | Functional | pKi | = | 7.1 | 7.1 | - | 0 | ChEMBL | 582 | 9 | 2 | 6 | 5.9 | O=C(NCCN1CCCCC1)c1cccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924007 | 69139 | None | 0 | Human | Functional | pKi | = | 7.1 | 7.1 | - | 0 | ChEMBL | 582 | 9 | 2 | 6 | 5.9 | O=C(NCCN1CCCCC1)c1cccc(Oc2ncc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1 | 10.1016/j.bmcl.2011.10.038 | |||
15985912 | 84009 | None | 0 | Human | Functional | pKi | = | 7.1 | 7.1 | - | 0 | ChEMBL | 416 | 5 | 1 | 5 | 4.1 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
CHEMBL2207081 | 84009 | None | 0 | Human | Functional | pKi | = | 7.1 | 7.1 | - | 0 | ChEMBL | 416 | 5 | 1 | 5 | 4.1 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
71214709 | 84012 | None | 0 | Human | Functional | pKi | = | 7.1 | 7.1 | - | 0 | ChEMBL | 431 | 5 | 1 | 6 | 3.8 | Cc1nnnn1Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
CHEMBL2207084 | 84012 | None | 0 | Human | Functional | pKi | = | 7.1 | 7.1 | - | 0 | ChEMBL | 431 | 5 | 1 | 6 | 3.8 | Cc1nnnn1Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
71214709 | 84012 | None | 0 | Human | Functional | pKi | = | 7.1 | 7.1 | - | 0 | ChEMBL | 431 | 5 | 1 | 6 | 3.8 | Cc1nnnn1Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
CHEMBL2207084 | 84012 | None | 0 | Human | Functional | pKi | = | 7.1 | 7.1 | - | 0 | ChEMBL | 431 | 5 | 1 | 6 | 3.8 | Cc1nnnn1Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
25110660 | 154962 | None | 0 | Human | Functional | pKi | = | 7.1 | 7.1 | - | 0 | ChEMBL | 525 | 6 | 3 | 3 | 6.7 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@@H](CN2CCC(c3c[nH]c4ccc(O)cc34)CC2)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL400698 | 154962 | None | 0 | Human | Functional | pKi | = | 7.1 | 7.1 | - | 0 | ChEMBL | 525 | 6 | 3 | 3 | 6.7 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@@H](CN2CCC(c3c[nH]c4ccc(O)cc34)CC2)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
44296628 | 188822 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 483 | 9 | 2 | 2 | 6.4 | O=C(/C=C/c1cccc(C(F)(F)F)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL50460 | 188822 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 483 | 9 | 2 | 2 | 6.4 | O=C(/C=C/c1cccc(C(F)(F)F)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
44296266 | 195221 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 429 | 9 | 2 | 2 | 5.7 | Cc1cccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)c1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL53991 | 195221 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 429 | 9 | 2 | 2 | 5.7 | Cc1cccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)c1 | 10.1016/s0960-894x(00)00347-4 | |||
44296628 | 188822 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 483 | 9 | 2 | 2 | 6.4 | O=C(/C=C/c1cccc(C(F)(F)F)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL50460 | 188822 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 483 | 9 | 2 | 2 | 6.4 | O=C(/C=C/c1cccc(C(F)(F)F)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
44296266 | 195221 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 429 | 9 | 2 | 2 | 5.7 | Cc1cccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)c1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL53991 | 195221 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 429 | 9 | 2 | 2 | 5.7 | Cc1cccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)c1 | 10.1016/j.bmcl.2007.12.072 | |||
57396690 | 69142 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 582 | 9 | 2 | 6 | 5.9 | O=C(NCCN1CCCCC1)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924010 | 69142 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 582 | 9 | 2 | 6 | 5.9 | O=C(NCCN1CCCCC1)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2011.10.038 | |||
49798396 | 10762 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 439 | 6 | 2 | 6 | 4.1 | O=C(O)c1ccccc1Oc1nccnc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171398 | 10762 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 439 | 6 | 2 | 6 | 4.1 | O=C(O)c1ccccc1Oc1nccnc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
19430534 | 10776 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 471 | 6 | 2 | 4 | 5.7 | O=C(O)c1ccccc1Oc1ccc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171586 | 10776 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 471 | 6 | 2 | 4 | 5.7 | O=C(O)c1ccccc1Oc1ccc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | |||
44296628 | 188822 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 483 | 9 | 2 | 2 | 6.4 | O=C(/C=C/c1cccc(C(F)(F)F)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL50460 | 188822 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 483 | 9 | 2 | 2 | 6.4 | O=C(/C=C/c1cccc(C(F)(F)F)c1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
44296266 | 195221 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 429 | 9 | 2 | 2 | 5.7 | Cc1cccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)c1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL53991 | 195221 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 429 | 9 | 2 | 2 | 5.7 | Cc1cccc(/C=C/C(=O)NCCCCCN2CCC(c3c[nH]c4ccccc34)CC2)c1 | 10.1016/j.bmcl.2007.12.072 | |||
57397001 | 69150 | None | 0 | Human | Functional | pKi | = | 8.1 | 8.1 | - | 0 | ChEMBL | 615 | 9 | 2 | 5 | 6.7 | Cc1cc(Oc2ccc(C(=O)NCCN3CCCC3)cc2)c(NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1Cl | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924018 | 69150 | None | 0 | Human | Functional | pKi | = | 8.1 | 8.1 | - | 0 | ChEMBL | 615 | 9 | 2 | 5 | 6.7 | Cc1cc(Oc2ccc(C(=O)NCCN3CCCC3)cc2)c(NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1Cl | 10.1016/j.bmcl.2011.10.038 | |||
57395221 | 69155 | None | 0 | Human | Functional | pKi | = | 8.1 | 8.1 | - | 0 | ChEMBL | 615 | 9 | 2 | 5 | 6.7 | Cc1cc(C(=O)NCCN2CCCC2)ccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.10.038 | |||
CHEMBL1924023 | 69155 | None | 0 | Human | Functional | pKi | = | 8.1 | 8.1 | - | 0 | ChEMBL | 615 | 9 | 2 | 5 | 6.7 | Cc1cc(C(=O)NCCN2CCCC2)ccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1 | 10.1016/j.bmcl.2011.10.038 | |||
44296429 | 194818 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 415 | 9 | 2 | 2 | 5.3 | O=C(/C=C/c1ccccc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL53402 | 194818 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 415 | 9 | 2 | 2 | 5.3 | O=C(/C=C/c1ccccc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/s0960-894x(00)00347-4 | |||
44296429 | 194818 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 415 | 9 | 2 | 2 | 5.3 | O=C(/C=C/c1ccccc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL53402 | 194818 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 415 | 9 | 2 | 2 | 5.3 | O=C(/C=C/c1ccccc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
44296429 | 194818 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 415 | 9 | 2 | 2 | 5.3 | O=C(/C=C/c1ccccc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
CHEMBL53402 | 194818 | None | 0 | Human | Functional | pKi | = | 6.1 | 6.1 | - | 0 | ChEMBL | 415 | 9 | 2 | 2 | 5.3 | O=C(/C=C/c1ccccc1)NCCCCCN1CCC(c2c[nH]c3ccccc23)CC1 | 10.1016/j.bmcl.2007.12.072 | |||
8921 | 3138 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | - | 1 | Guide to Pharmacology | None | None | None | None | None | |||||
11185 | 1991 | None | 42 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | Guide to Pharmacology | 495 | 5 | 2 | 6 | 4.4 | Cc1cnc(c(c1)NS(=O)(=O)c1ccc(c(c1)C(F)(F)F)Cl)C(=O)c1ncnc2c1cc[nH]2 | None | |||
25134303 | 1991 | None | 42 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | Guide to Pharmacology | 495 | 5 | 2 | 6 | 4.4 | Cc1cnc(c(c1)NS(=O)(=O)c1ccc(c(c1)C(F)(F)F)Cl)C(=O)c1ncnc2c1cc[nH]2 | None | |||
CHEMBL2178573 | 1991 | None | 42 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | Guide to Pharmacology | 495 | 5 | 2 | 6 | 4.4 | Cc1cnc(c(c1)NS(=O)(=O)c1ccc(c(c1)C(F)(F)F)Cl)C(=O)c1ncnc2c1cc[nH]2 | None | |||
DB16066 | 1991 | None | 42 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | Guide to Pharmacology | 495 | 5 | 2 | 6 | 4.4 | Cc1cnc(c(c1)NS(=O)(=O)c1ccc(c(c1)C(F)(F)F)Cl)C(=O)c1ncnc2c1cc[nH]2 | None | |||
769 | 827 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | -28 | 3 | Guide to Pharmacology | None | None | None | None | 12554737 | |||||
769 | 827 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | -28 | 3 | Guide to Pharmacology | None | None | None | None | 15207250 | |||||
11192346 | 2024 | None | 45 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 1 | 3 | Guide to Pharmacology | 568 | 7 | 3 | 7 | 3.3 | O=C(N1CC[C@@H](C1)NC1CCC(CC1)(O)c1ccc(cn1)c1ncccn1)CNC(=O)c1cccc(c1)C(F)(F)F | 24900280 | |||
9032 | 2024 | None | 45 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 1 | 3 | Guide to Pharmacology | 568 | 7 | 3 | 7 | 3.3 | O=C(N1CC[C@@H](C1)NC1CCC(CC1)(O)c1ccc(cn1)c1ncccn1)CNC(=O)c1cccc(c1)C(F)(F)F | 24900280 | |||
CHEMBL2029422 | 2024 | None | 45 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 1 | 3 | Guide to Pharmacology | 568 | 7 | 3 | 7 | 3.3 | O=C(N1CC[C@@H](C1)NC1CCC(CC1)(O)c1ccc(cn1)c1ncccn1)CNC(=O)c1cccc(c1)C(F)(F)F | 24900280 | |||
11527661 | 2021 | None | 28 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | Guide to Pharmacology | 520 | 7 | 3 | 6 | 2.9 | COc1ccc(cn1)C1(O)CCC(CC1)N1CC[C@H](C1)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F | 24900329 | |||
9045 | 2021 | None | 28 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | Guide to Pharmacology | 520 | 7 | 3 | 6 | 2.9 | COc1ccc(cn1)C1(O)CCC(CC1)N1CC[C@H](C1)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F | 24900329 | |||
CHEMBL1963131 | 2021 | None | 28 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | Guide to Pharmacology | 520 | 7 | 3 | 6 | 2.9 | COc1ccc(cn1)C1(O)CCC(CC1)N1CC[C@H](C1)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F | 24900329 | |||
776 | 853 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 1 | 2 | Guide to Pharmacology | None | None | None | None | 15207250 | |||||
759 | 866 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | Guide to Pharmacology | None | None | None | None | 12554737 | |||||
759 | 866 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | Guide to Pharmacology | None | None | None | None | 9276730 | |||||
759 | 866 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | Guide to Pharmacology | None | None | None | None | 9346309 | |||||
11597 | 674 | None | 6 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 11 | 2 | Guide to Pharmacology | 506 | 5 | 3 | 6 | 3.5 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C | 34141082 | |||
23725180 | 674 | None | 6 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 11 | 2 | Guide to Pharmacology | 506 | 5 | 3 | 6 | 3.5 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C | 34141082 | |||
CHEMBL4781426 | 674 | None | 6 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 11 | 2 | Guide to Pharmacology | 506 | 5 | 3 | 6 | 3.5 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C | 34141082 | |||
46213922 | 546 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | Guide to Pharmacology | 411 | 3 | 2 | 4 | 1.8 | O=C(N1CCN(CC1)C(=O)[C@@H]1NCCN(C1)C(C)C)Nc1ccc(c(c1)F)Cl | None | |||
57656761 | 546 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | Guide to Pharmacology | 411 | 3 | 2 | 4 | 1.8 | O=C(N1CCN(CC1)C(=O)[C@@H]1NCCN(C1)C(C)C)Nc1ccc(c(c1)F)Cl | None | |||
7825 | 546 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | Guide to Pharmacology | 411 | 3 | 2 | 4 | 1.8 | O=C(N1CCN(CC1)C(=O)[C@@H]1NCCN(C1)C(C)C)Nc1ccc(c(c1)F)Cl | None | |||
772 | 869 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | Guide to Pharmacology | None | None | None | None | 12554737 | |||||
770 | 828 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | -7 | 2 | Guide to Pharmacology | None | None | None | None | 12554737 | |||||
770 | 828 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | -7 | 2 | Guide to Pharmacology | None | None | None | None | 9276730 | |||||
68764898 | 672 | None | 2 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 3 | 2 | Guide to Pharmacology | 491 | 7 | 1 | 5 | 5.3 | CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 25893046 | |||
9430 | 672 | None | 2 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 3 | 2 | Guide to Pharmacology | 491 | 7 | 1 | 5 | 5.3 | CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 25893046 | |||
CHEMBL3577945 | 672 | None | 2 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 3 | 2 | Guide to Pharmacology | 491 | 7 | 1 | 5 | 5.3 | CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 25893046 | |||
771 | 838 | None | 0 | Human | Functional | pIC50 | = | 9.8 | 9.8 | - | 1 | Guide to Pharmacology | None | None | None | None | 10770925 | |||||
771 | 838 | None | 0 | Human | Functional | pIC50 | = | 9.8 | 9.8 | - | 1 | Guide to Pharmacology | None | None | None | None | 12554737 | |||||
771 | 838 | None | 0 | Human | Functional | pIC50 | = | 9.8 | 9.8 | - | 1 | Guide to Pharmacology | None | None | None | None | 15207250 | |||||
771 | 838 | None | 0 | Human | Functional | pIC50 | = | 9.8 | 9.8 | - | 1 | Guide to Pharmacology | None | None | None | None | 9276730 | |||||
771 | 838 | None | 0 | Human | Functional | pIC50 | = | 9.8 | 9.8 | - | 1 | Guide to Pharmacology | None | None | None | None | 9346309 | |||||
775 | 849 | None | 0 | Human | Functional | pIC50 | None | 6.2 | 6.2 | -316 | 2 | Guide to Pharmacology | None | None | None | None | 15207250 | |||||
10000456 | 3389 | None | 28 | Human | Functional | pIC50 | None | 6.3 | 6.3 | 1 | 2 | Guide to Pharmacology | 390 | 3 | 1 | 3 | 4.8 | O=C1Nc2ccccc2C2(O1)CCN(CC2)CCc1ccc(cc1)C(F)(F)F | 10770925 | |||
779 | 3389 | None | 28 | Human | Functional | pIC50 | None | 6.3 | 6.3 | 1 | 2 | Guide to Pharmacology | 390 | 3 | 1 | 3 | 4.8 | O=C1Nc2ccccc2C2(O1)CCN(CC2)CCc1ccc(cc1)C(F)(F)F | 10770925 | |||
CHEMBL1593104 | 3389 | None | 28 | Human | Functional | pIC50 | None | 6.3 | 6.3 | 1 | 2 | Guide to Pharmacology | 390 | 3 | 1 | 3 | 4.8 | O=C1Nc2ccccc2C2(O1)CCN(CC2)CCc1ccc(cc1)C(F)(F)F | 10770925 | |||
774 | 3977 | None | 0 | Human | Functional | pIC50 | None | 7.1 | 7.1 | - | 1 | Guide to Pharmacology | None | None | None | None | 12554737 | |||||
10008367 | 2022 | None | 36 | Mouse | Functional | pIC50 | None | 8 | 8.0 | -1 | 3 | Guide to Pharmacology | 577 | 8 | 3 | 7 | 3.2 | CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@@H]1CC[C@](CC1)(O)c1ccc2c(c1)OCO2 | 16210643 | |||
777 | 2022 | None | 36 | Mouse | Functional | pIC50 | None | 8 | 8.0 | -1 | 3 | Guide to Pharmacology | 577 | 8 | 3 | 7 | 3.2 | CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@@H]1CC[C@](CC1)(O)c1ccc2c(c1)OCO2 | 16210643 | |||
CHEMBL1289316 | 2022 | None | 36 | Mouse | Functional | pIC50 | None | 8 | 8.0 | -1 | 3 | Guide to Pharmacology | 577 | 8 | 3 | 7 | 3.2 | CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@@H]1CC[C@](CC1)(O)c1ccc2c(c1)OCO2 | 16210643 | |||
CHEMBL2426341 | 2022 | None | 36 | Mouse | Functional | pIC50 | None | 8 | 8.0 | -1 | 3 | Guide to Pharmacology | 577 | 8 | 3 | 7 | 3.2 | CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@@H]1CC[C@](CC1)(O)c1ccc2c(c1)OCO2 | 16210643 | |||
CHEMBL5268600 | 2022 | None | 36 | Mouse | Functional | pIC50 | None | 8 | 8.0 | -1 | 3 | Guide to Pharmacology | 577 | 8 | 3 | 7 | 3.2 | CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@@H]1CC[C@](CC1)(O)c1ccc2c(c1)OCO2 | 16210643 | |||
773 | 1937 | None | 0 | Human | Functional | pIC50 | None | 8.3 | 8.3 | 12 | 2 | Guide to Pharmacology | None | None | None | None | 9789057 | |||||
5071702 | 3392 | None | 0 | Human | Functional | pIC50 | None | 8.5 | 8.5 | - | 1 | Guide to Pharmacology | 235 | 3 | 1 | 2 | 2.9 | Clc1cccc(c1)Cn1cccc1C(=O)O | 10770925 | |||
780 | 3392 | None | 0 | Human | Functional | pIC50 | None | 8.5 | 8.5 | - | 1 | Guide to Pharmacology | 235 | 3 | 1 | 2 | 2.9 | Clc1cccc(c1)Cn1cccc1C(=O)O | 10770925 | |||
778 | 2468 | None | 0 | Human | Functional | pIC50 | None | 8.8 | 8.8 | - | 1 | Guide to Pharmacology | None | None | None | None | 9600978 | |||||
486830 | 4002 | None | 0 | Human | Functional | pIC50 | None | 9.1 | 9.1 | 6 | 5 | Guide to Pharmacology | None | None | None | None | 9287217 | |||||
768 | 4002 | None | 0 | Human | Functional | pIC50 | None | 9.1 | 9.1 | 6 | 5 | Guide to Pharmacology | None | None | None | None | 9287217 |
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
183790 | 3742 | None | 8 | Human | Binding | pIC50 | = | 10.5 | 10.5 | -6 | 2 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1074/jbc.m705302200 | |||
783 | 3742 | None | 8 | Human | Binding | pIC50 | = | 10.5 | 10.5 | -6 | 2 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1074/jbc.m705302200 | |||
CHEMBL1178786 | 3742 | None | 8 | Human | Binding | pIC50 | = | 10.5 | 10.5 | -6 | 2 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1074/jbc.m705302200 | |||
4410 | 3137 | None | 64 | Human | Binding | pIC50 | = | 10.4 | 10.4 | - | 5 | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m705302200 | |||
65015 | 3137 | None | 64 | Human | Binding | pIC50 | = | 10.4 | 10.4 | - | 5 | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m705302200 | |||
65015.0 | 3137 | None | 64 | Human | Binding | pIC50 | = | 10.4 | 10.4 | - | 5 | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m705302200 | |||
844 | 3137 | None | 64 | Human | Binding | pIC50 | = | 10.4 | 10.4 | - | 5 | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m705302200 | |||
CHEMBL18442 | 3137 | None | 64 | Human | Binding | pIC50 | = | 10.4 | 10.4 | - | 5 | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m705302200 | |||
DB06809 | 3137 | None | 64 | Human | Binding | pIC50 | = | 10.4 | 10.4 | - | 5 | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m705302200 | |||
183790 | 3742 | None | 8 | Human | Binding | pIC50 | = | 10.1 | 10.1 | -6 | 2 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1074/jbc.m705302200 | |||
783 | 3742 | None | 8 | Human | Binding | pIC50 | = | 10.1 | 10.1 | -6 | 2 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1074/jbc.m705302200 | |||
CHEMBL1178786 | 3742 | None | 8 | Human | Binding | pIC50 | = | 10.1 | 10.1 | -6 | 2 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1074/jbc.m705302200 | |||
4410 | 3137 | None | 64 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 5 | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m705302200 | |||
65015 | 3137 | None | 64 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 5 | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m705302200 | |||
65015.0 | 3137 | None | 64 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 5 | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m705302200 | |||
844 | 3137 | None | 64 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 5 | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m705302200 | |||
CHEMBL18442 | 3137 | None | 64 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 5 | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m705302200 | |||
DB06809 | 3137 | None | 64 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 5 | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m705302200 | |||
68767577 | 109872 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 545 | 8 | 1 | 5 | 3.7 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)C(C)C)C1 | 10.1016/j.bmcl.2014.02.013 | |||
CHEMBL3233186 | 109872 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 545 | 8 | 1 | 5 | 3.7 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)C(C)C)C1 | 10.1016/j.bmcl.2014.02.013 | |||
68988296 | 109874 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 559 | 7 | 1 | 5 | 4.1 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)C(C)(C)C)C1 | 10.1016/j.bmcl.2014.02.013 | |||
CHEMBL3233188 | 109874 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 559 | 7 | 1 | 5 | 4.1 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)C(C)(C)C)C1 | 10.1016/j.bmcl.2014.02.013 | |||
11627840 | 95752 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 525 | 6 | 2 | 3 | 6.0 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)N1CCC(C(CO)N2CCC(c3c[nH]c4ccccc34)CC2)CC1 | 10.1016/j.bmcl.2008.05.010 | |||
CHEMBL258205 | 95752 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 525 | 6 | 2 | 3 | 6.0 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)N1CCC(C(CO)N2CCC(c3c[nH]c4ccccc34)CC2)CC1 | 10.1016/j.bmcl.2008.05.010 | |||
68764898 | 672 | None | 2 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 3 | ChEMBL | 491 | 7 | 1 | 5 | 5.3 | CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1021/ml500505q | |||
9430 | 672 | None | 2 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 3 | ChEMBL | 491 | 7 | 1 | 5 | 5.3 | CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1021/ml500505q | |||
CHEMBL3577945 | 672 | None | 2 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 3 | ChEMBL | 491 | 7 | 1 | 5 | 5.3 | CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1021/ml500505q | |||
183790 | 3742 | None | 8 | Human | Binding | pIC50 | = | 9.6 | 9.6 | -6 | 2 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1074/jbc.m705302200 | |||
783 | 3742 | None | 8 | Human | Binding | pIC50 | = | 9.6 | 9.6 | -6 | 2 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1074/jbc.m705302200 | |||
CHEMBL1178786 | 3742 | None | 8 | Human | Binding | pIC50 | = | 9.6 | 9.6 | -6 | 2 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1074/jbc.m705302200 | |||
90656027 | 111189 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 557 | 4 | 1 | 5 | 4.6 | CNC(=O)c1cccc(C2CCN([C@@H]3C[C@H]4OCC[C@@]4(C(=O)N4COc5ccc(C(F)(F)F)cc5C4)C3)CC2)c1 | 10.1016/j.bmcl.2014.03.036 | |||
CHEMBL3263286 | 111189 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 557 | 4 | 1 | 5 | 4.6 | CNC(=O)c1cccc(C2CCN([C@@H]3C[C@H]4OCC[C@@]4(C(=O)N4COc5ccc(C(F)(F)F)cc5C4)C3)CC2)c1 | 10.1016/j.bmcl.2014.03.036 | |||
91884571 | 181566 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 471 | 5 | 3 | 5 | 2.5 | CC(=O)N[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1N1CC[C@H](NC(=O)c2cccc(C(C)(C)C)n2)C1=O | 10.1021/acsmedchemlett.1c00082 | |||
CHEMBL4764460 | 181566 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 471 | 5 | 3 | 5 | 2.5 | CC(=O)N[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1N1CC[C@H](NC(=O)c2cccc(C(C)(C)C)n2)C1=O | 10.1021/acsmedchemlett.1c00082 | |||
46886055 | 8046 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 593 | 9 | 1 | 5 | 4.8 | CCN(C(C)C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2010.03.035 | |||
CHEMBL1090893 | 8046 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 593 | 9 | 1 | 5 | 4.8 | CCN(C(C)C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2010.03.035 | |||
68767577 | 109872 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 545 | 8 | 1 | 5 | 3.7 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)C(C)C)C1 | 10.1016/j.bmcl.2014.02.013 | |||
CHEMBL3233186 | 109872 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 545 | 8 | 1 | 5 | 3.7 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)C(C)C)C1 | 10.1016/j.bmcl.2014.02.013 | |||
10289827 | 188082 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 571 | 9 | 2 | 6 | 3.8 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C)CC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL497202 | 188082 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 571 | 9 | 2 | 6 | 3.8 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C)CC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
46886536 | 8308 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 593 | 8 | 1 | 5 | 4.7 | Cc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)cc1 | 10.1016/j.bmcl.2010.03.035 | |||
CHEMBL1092678 | 8308 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 593 | 8 | 1 | 5 | 4.7 | Cc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)cc1 | 10.1016/j.bmcl.2010.03.035 | |||
154572822 | 171204 | None | 1 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 542 | 7 | 2 | 7 | 2.8 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](Nc3ncnc4ccc(C(F)(F)F)cc34)C2=O)[C@H](NS(C)(=O)=O)C1 | 10.1021/acsmedchemlett.8b00439 | |||
CHEMBL4457723 | 171204 | None | 1 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 542 | 7 | 2 | 7 | 2.8 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](Nc3ncnc4ccc(C(F)(F)F)cc34)C2=O)[C@H](NS(C)(=O)=O)C1 | 10.1021/acsmedchemlett.8b00439 | |||
16064151 | 121303 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 491 | 6 | 1 | 5 | 5.2 | CC(C)[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1CC[C@H](Nc2ncnc3ccc(C(F)(F)F)cc23)C1=O | 10.1021/ml500505q | |||
CHEMBL3577948 | 121303 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 491 | 6 | 1 | 5 | 5.2 | CC(C)[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1CC[C@H](Nc2ncnc3ccc(C(F)(F)F)cc23)C1=O | 10.1021/ml500505q | |||
44425292 | 86002 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 627 | 9 | 3 | 5 | 6.6 | CNC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
CHEMBL230281 | 86002 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 627 | 9 | 3 | 5 | 6.6 | CNC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
68764925 | 121301 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 477 | 6 | 1 | 5 | 4.9 | CC[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1CC[C@H](Nc2ncnc3ccc(C(F)(F)F)cc23)C1=O | 10.1021/ml500505q | |||
CHEMBL3577946 | 121301 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 477 | 6 | 1 | 5 | 4.9 | CC[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1CC[C@H](Nc2ncnc3ccc(C(F)(F)F)cc23)C1=O | 10.1021/ml500505q | |||
46865775 | 8116 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 579 | 8 | 1 | 5 | 4.4 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2014.02.013 | |||
CHEMBL1091605 | 8116 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 579 | 8 | 1 | 5 | 4.4 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2014.02.013 | |||
68769744 | 109873 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 533 | 8 | 1 | 5 | 4.0 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(C)(C)C)c3)C2=O)[C@H](CS(=O)(=O)C(C)C)C1 | 10.1016/j.bmcl.2014.02.013 | |||
CHEMBL3233187 | 109873 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 533 | 8 | 1 | 5 | 4.0 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(C)(C)C)c3)C2=O)[C@H](CS(=O)(=O)C(C)C)C1 | 10.1016/j.bmcl.2014.02.013 | |||
11192346 | 2024 | None | 45 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(N1CC[C@@H](C1)NC1CCC(CC1)(O)c1ccc(cn1)c1ncccn1)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200199c | |||
9032 | 2024 | None | 45 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(N1CC[C@@H](C1)NC1CCC(CC1)(O)c1ccc(cn1)c1ncccn1)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200199c | |||
CHEMBL2029422 | 2024 | None | 45 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(N1CC[C@@H](C1)NC1CCC(CC1)(O)c1ccc(cn1)c1ncccn1)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200199c | |||
68764925 | 121301 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 477 | 6 | 1 | 5 | 4.9 | CC[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1CC[C@H](Nc2ncnc3ccc(C(F)(F)F)cc23)C1=O | 10.1021/ml500505q | |||
CHEMBL3577946 | 121301 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 477 | 6 | 1 | 5 | 4.9 | CC[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1CC[C@H](Nc2ncnc3ccc(C(F)(F)F)cc23)C1=O | 10.1021/ml500505q | |||
68767049 | 121298 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 553 | 9 | 3 | 4 | 4.9 | CCC[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NCC)C1=O | 10.1021/ml500505q | |||
CHEMBL3577942 | 121298 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 553 | 9 | 3 | 4 | 4.9 | CCC[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NCC)C1=O | 10.1021/ml500505q | |||
162668957 | 182866 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 495 | 5 | 3 | 7 | 3.1 | CC(=O)N[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1N1CC[C@H](Nc2ncnc3ccc(C(C)(C)C)nc23)C1=O | 10.1021/acsmedchemlett.1c00082 | |||
CHEMBL4790208 | 182866 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 495 | 5 | 3 | 7 | 3.1 | CC(=O)N[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1N1CC[C@H](Nc2ncnc3ccc(C(C)(C)C)nc23)C1=O | 10.1021/acsmedchemlett.1c00082 | |||
68769143 | 109870 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 531 | 8 | 1 | 5 | 3.3 | CCS(=O)(=O)C[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1CC[C@H](NC(=O)c2cccc(C(F)(F)F)c2)C1=O | 10.1016/j.bmcl.2014.02.013 | |||
CHEMBL3233184 | 109870 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 531 | 8 | 1 | 5 | 3.3 | CCS(=O)(=O)C[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1CC[C@H](NC(=O)c2cccc(C(F)(F)F)c2)C1=O | 10.1016/j.bmcl.2014.02.013 | |||
11643006 | 95327 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 618 | 8 | 3 | 5 | 5.3 | CS(=O)(=O)Nc1ccc2[nH]cc(C3CCN(C(CO)C4CCN(C(=O)/C=C/c5ccc(Cl)c(Cl)c5)CC4)CC3)c2c1 | 10.1016/j.bmcl.2008.05.010 | |||
CHEMBL256301 | 95327 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 618 | 8 | 3 | 5 | 5.3 | CS(=O)(=O)Nc1ccc2[nH]cc(C3CCN(C(CO)C4CCN(C(=O)/C=C/c5ccc(Cl)c(Cl)c5)CC4)CC3)c2c1 | 10.1016/j.bmcl.2008.05.010 | |||
11540494 | 95523 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 493 | 6 | 2 | 3 | 4.9 | O=C(/C=C/c1cc(F)cc(F)c1)N1CCC(C(CO)N2CCC(c3c[nH]c4ccccc34)CC2)CC1 | 10.1016/j.bmcl.2008.05.010 | |||
CHEMBL257191 | 95523 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 493 | 6 | 2 | 3 | 4.9 | O=C(/C=C/c1cc(F)cc(F)c1)N1CCC(C(CO)N2CCC(c3c[nH]c4ccccc34)CC2)CC1 | 10.1016/j.bmcl.2008.05.010 | |||
11598 | 673 | None | 13 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 506 | 6 | 2 | 6 | 3.4 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1021/acsmedchemlett.8b00439 | |||
23725177 | 673 | None | 13 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 506 | 6 | 2 | 6 | 3.4 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1021/acsmedchemlett.8b00439 | |||
CHEMBL4442783 | 673 | None | 13 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 506 | 6 | 2 | 6 | 3.4 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1021/acsmedchemlett.8b00439 | |||
11598 | 673 | None | 13 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 506 | 6 | 2 | 6 | 3.4 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1021/acsmedchemlett.1c00082 | |||
23725177 | 673 | None | 13 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 506 | 6 | 2 | 6 | 3.4 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1021/acsmedchemlett.1c00082 | |||
CHEMBL4442783 | 673 | None | 13 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 506 | 6 | 2 | 6 | 3.4 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1021/acsmedchemlett.1c00082 | |||
68767802 | 109867 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 506 | 7 | 1 | 6 | 2.6 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(C)(C)C)n3)C2=O)[C@H](CS(C)(=O)=O)C1 | 10.1016/j.bmcl.2014.02.013 | |||
CHEMBL3233181 | 109867 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 506 | 7 | 1 | 6 | 2.6 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(C)(C)C)n3)C2=O)[C@H](CS(C)(=O)=O)C1 | 10.1016/j.bmcl.2014.02.013 | |||
68764898 | 672 | None | 2 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 3 | ChEMBL | 491 | 7 | 1 | 5 | 5.3 | CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1021/acsmedchemlett.8b00439 | |||
9430 | 672 | None | 2 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 3 | ChEMBL | 491 | 7 | 1 | 5 | 5.3 | CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1021/acsmedchemlett.8b00439 | |||
CHEMBL3577945 | 672 | None | 2 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 3 | ChEMBL | 491 | 7 | 1 | 5 | 5.3 | CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1021/acsmedchemlett.8b00439 | |||
68764898 | 672 | None | 2 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 3 | ChEMBL | 491 | 7 | 1 | 5 | 5.3 | CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1021/ml500505q | |||
9430 | 672 | None | 2 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 3 | ChEMBL | 491 | 7 | 1 | 5 | 5.3 | CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1021/ml500505q | |||
CHEMBL3577945 | 672 | None | 2 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 3 | ChEMBL | 491 | 7 | 1 | 5 | 5.3 | CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1021/ml500505q | |||
11597 | 674 | None | 6 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 506 | 5 | 3 | 6 | 3.5 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C | 10.1021/acsmedchemlett.1c00082 | |||
23725180 | 674 | None | 6 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 506 | 5 | 3 | 6 | 3.5 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C | 10.1021/acsmedchemlett.1c00082 | |||
CHEMBL4781426 | 674 | None | 6 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 506 | 5 | 3 | 6 | 3.5 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C | 10.1021/acsmedchemlett.1c00082 | |||
46865774 | 8115 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 553 | 9 | 2 | 5 | 3.9 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2010.03.035 | |||
CHEMBL1091604 | 8115 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 553 | 9 | 2 | 5 | 3.9 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2010.03.035 | |||
46886539 | 8351 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 597 | 8 | 1 | 5 | 4.5 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cc(F)cc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2010.03.035 | |||
CHEMBL1092941 | 8351 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 597 | 8 | 1 | 5 | 4.5 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cc(F)cc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2010.03.035 | |||
46865774 | 8115 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 553 | 9 | 2 | 5 | 3.9 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2011.12.057 | |||
CHEMBL1091604 | 8115 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 553 | 9 | 2 | 5 | 3.9 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2011.12.057 | |||
44425294 | 143452 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 651 | 8 | 3 | 5 | 6.8 | CNC(=O)Nc1nc([C@H](CCN2CCC3(C=Cc4ccccc43)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
CHEMBL389771 | 143452 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 651 | 8 | 3 | 5 | 6.8 | CNC(=O)Nc1nc([C@H](CCN2CCC3(C=Cc4ccccc43)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
46865774 | 8115 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 553 | 9 | 2 | 5 | 3.9 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1021/ml500505q | |||
CHEMBL1091604 | 8115 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 553 | 9 | 2 | 5 | 3.9 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1021/ml500505q | |||
66767933 | 121289 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 531 | 12 | 6 | 5 | 3.2 | CCC[C@H](O)[C@H](CNCC(C)(C)C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)NC(C)C | 10.1021/ml500505q | |||
CHEMBL3577933 | 121289 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 531 | 12 | 6 | 5 | 3.2 | CCC[C@H](O)[C@H](CNCC(C)(C)C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)NC(C)C | 10.1021/ml500505q | |||
11192943 | 77653 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 628 | 8 | 2 | 5 | 5.4 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)Cc2nc3cccc(C(F)(F)F)c3[nH]2)[C@H](CS(=O)(=O)c2ccc(Br)cc2)C1 | 10.1016/j.bmcl.2012.08.002 | |||
CHEMBL2088212 | 77653 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 628 | 8 | 2 | 5 | 5.4 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)Cc2nc3cccc(C(F)(F)F)c3[nH]2)[C@H](CS(=O)(=O)c2ccc(Br)cc2)C1 | 10.1016/j.bmcl.2012.08.002 | |||
68772423 | 172067 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 541 | 7 | 1 | 7 | 3.6 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](Nc3ncnc4ccc(C(F)(F)F)cc34)C2=O)[C@H](CS(C)(=O)=O)C1 | 10.1021/acsmedchemlett.8b00439 | |||
CHEMBL4470701 | 172067 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 541 | 7 | 1 | 7 | 3.6 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](Nc3ncnc4ccc(C(F)(F)F)cc34)C2=O)[C@H](CS(C)(=O)=O)C1 | 10.1021/acsmedchemlett.8b00439 | |||
50925394 | 19335 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 517 | 8 | 2 | 4 | 4.4 | CCO[C@H]1CN([C@H]2CC[C@@H](c3ccccc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.10.020 | |||
CHEMBL1290636 | 19335 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 517 | 8 | 2 | 4 | 4.4 | CCO[C@H]1CN([C@H]2CC[C@@H](c3ccccc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.10.020 | |||
22143334 | 187914 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 509 | 8 | 4 | 6 | 2.7 | CSc1ccc(CNC2CCN(C)CC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL495924 | 187914 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 509 | 8 | 4 | 6 | 2.7 | CSc1ccc(CNC2CCN(C)CC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
68988296 | 109874 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 559 | 7 | 1 | 5 | 4.1 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)C(C)(C)C)C1 | 10.1016/j.bmcl.2014.02.013 | |||
CHEMBL3233188 | 109874 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 559 | 7 | 1 | 5 | 4.1 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)C(C)(C)C)C1 | 10.1016/j.bmcl.2014.02.013 | |||
11721374 | 95046 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 604 | 8 | 3 | 5 | 4.4 | CS(=O)(=O)Nc1ccc2[nH]cc(C3CCN(C(CO)C4CCN(C(=O)/C=C/c5cc(F)c(F)c(F)c5)CC4)CC3)c2c1 | 10.1016/j.bmcl.2008.05.010 | |||
CHEMBL254772 | 95046 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 604 | 8 | 3 | 5 | 4.4 | CS(=O)(=O)Nc1ccc2[nH]cc(C3CCN(C(CO)C4CCN(C(=O)/C=C/c5cc(F)c(F)c(F)c5)CC4)CC3)c2c1 | 10.1016/j.bmcl.2008.05.010 | |||
44448839 | 155544 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 526 | 6 | 3 | 4 | 4.7 | Nc1ccc2[nH]cc(C3CCN(C(CO)C4CCN(C(=O)/C=C/c5cc(F)c(F)c(F)c5)CC4)CC3)c2c1 | 10.1016/j.bmcl.2008.05.010 | |||
CHEMBL403889 | 155544 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 526 | 6 | 3 | 4 | 4.7 | Nc1ccc2[nH]cc(C3CCN(C(CO)C4CCN(C(=O)/C=C/c5cc(F)c(F)c(F)c5)CC4)CC3)c2c1 | 10.1016/j.bmcl.2008.05.010 | |||
44448879 | 155758 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 527 | 6 | 3 | 4 | 4.8 | O=C(/C=C/c1cc(F)c(F)c(F)c1)N1CCC(C(CO)N2CCC(c3c[nH]c4ccc(O)cc34)CC2)CC1 | 10.1016/j.bmcl.2008.05.010 | |||
CHEMBL404904 | 155758 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 527 | 6 | 3 | 4 | 4.8 | O=C(/C=C/c1cc(F)c(F)c(F)c1)N1CCC(C(CO)N2CCC(c3c[nH]c4ccc(O)cc34)CC2)CC1 | 10.1016/j.bmcl.2008.05.010 | |||
46865775 | 8116 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 579 | 8 | 1 | 5 | 4.4 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2010.03.035 | |||
CHEMBL1091605 | 8116 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 579 | 8 | 1 | 5 | 4.4 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2010.03.035 | |||
46865775 | 8116 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 579 | 8 | 1 | 5 | 4.4 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2014.02.013 | |||
CHEMBL1091605 | 8116 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 579 | 8 | 1 | 5 | 4.4 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2014.02.013 | |||
57402219 | 71032 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 503 | 6 | 3 | 4 | 3.8 | Cc1ccc([C@]2(O)CC[C@H](N3CC[C@@H](NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cc1 | 10.1021/ml200030q | |||
CHEMBL1951766 | 71032 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 503 | 6 | 3 | 4 | 3.8 | Cc1ccc([C@]2(O)CC[C@H](N3CC[C@@H](NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cc1 | 10.1021/ml200030q | |||
68767049 | 121298 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 553 | 9 | 3 | 4 | 4.9 | CCC[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NCC)C1=O | 10.1021/ml500505q | |||
CHEMBL3577942 | 121298 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 553 | 9 | 3 | 4 | 4.9 | CCC[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NCC)C1=O | 10.1021/ml500505q | |||
68867935 | 109871 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 539 | 9 | 1 | 5 | 4.0 | CCS(=O)(=O)C[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1CC[C@H](NC(=O)c2cccc(-c3ccccc3)c2)C1=O | 10.1016/j.bmcl.2014.02.013 | |||
CHEMBL3233185 | 109871 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 539 | 9 | 1 | 5 | 4.0 | CCS(=O)(=O)C[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1CC[C@H](NC(=O)c2cccc(-c3ccccc3)c2)C1=O | 10.1016/j.bmcl.2014.02.013 | |||
11598 | 673 | None | 13 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 506 | 6 | 2 | 6 | 3.4 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1021/acsmedchemlett.8b00439 | |||
23725177 | 673 | None | 13 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 506 | 6 | 2 | 6 | 3.4 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1021/acsmedchemlett.8b00439 | |||
CHEMBL4442783 | 673 | None | 13 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 506 | 6 | 2 | 6 | 3.4 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1021/acsmedchemlett.8b00439 | |||
11598 | 673 | None | 13 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 506 | 6 | 2 | 6 | 3.4 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1021/acsmedchemlett.1c00082 | |||
23725177 | 673 | None | 13 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 506 | 6 | 2 | 6 | 3.4 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1021/acsmedchemlett.1c00082 | |||
CHEMBL4442783 | 673 | None | 13 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 506 | 6 | 2 | 6 | 3.4 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1021/acsmedchemlett.1c00082 | |||
66768099 | 121288 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 517 | 13 | 6 | 5 | 2.9 | CCC[C@H](O)[C@H](CNCC(C)C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)NC(C)C | 10.1021/ml500505q | |||
CHEMBL3577932 | 121288 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 517 | 13 | 6 | 5 | 2.9 | CCC[C@H](O)[C@H](CNCC(C)C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1NC(=O)NC(C)C | 10.1021/ml500505q | |||
69035439 | 77677 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 576 | 7 | 1 | 5 | 5.2 | CC(C)N(C)[C@@H]1CC[C@H](N2CCC(c3nc4cccc(C(F)(F)F)c4[nH]3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2012.08.002 | |||
CHEMBL2088388 | 77677 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 576 | 7 | 1 | 5 | 5.2 | CC(C)N(C)[C@@H]1CC[C@H](N2CCC(c3nc4cccc(C(F)(F)F)c4[nH]3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2012.08.002 | |||
68767124 | 109866 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 505 | 7 | 1 | 5 | 3.2 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(C)(C)C)c3)C2=O)[C@H](CS(C)(=O)=O)C1 | 10.1016/j.bmcl.2014.02.013 | |||
CHEMBL3233180 | 109866 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 505 | 7 | 1 | 5 | 3.2 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(C)(C)C)c3)C2=O)[C@H](CS(C)(=O)=O)C1 | 10.1016/j.bmcl.2014.02.013 | |||
68769143 | 109870 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 531 | 8 | 1 | 5 | 3.3 | CCS(=O)(=O)C[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1CC[C@H](NC(=O)c2cccc(C(F)(F)F)c2)C1=O | 10.1016/j.bmcl.2014.02.013 | |||
CHEMBL3233184 | 109870 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 531 | 8 | 1 | 5 | 3.3 | CCS(=O)(=O)C[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1CC[C@H](NC(=O)c2cccc(C(F)(F)F)c2)C1=O | 10.1016/j.bmcl.2014.02.013 | |||
89845025 | 109875 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 575 | 8 | 1 | 6 | 4.0 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(OC(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)C(C)(C)C)C1 | 10.1016/j.bmcl.2014.02.013 | |||
CHEMBL3233189 | 109875 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 575 | 8 | 1 | 6 | 4.0 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(OC(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)C(C)(C)C)C1 | 10.1016/j.bmcl.2014.02.013 | |||
44593562 | 187601 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 494 | 6 | 2 | 3 | 5.6 | CC1COCCC1N[C@@H]1CC[C@@](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(C(C)C)C1 | 10.1016/j.bmcl.2008.12.050 | |||
CHEMBL494191 | 187601 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 494 | 6 | 2 | 3 | 5.6 | CC1COCCC1N[C@@H]1CC[C@@](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(C(C)C)C1 | 10.1016/j.bmcl.2008.12.050 | |||
46865774 | 8115 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 553 | 9 | 2 | 5 | 3.9 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1021/ml500505q | |||
CHEMBL1091604 | 8115 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 553 | 9 | 2 | 5 | 3.9 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1021/ml500505q | |||
68768923 | 109876 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 577 | 7 | 1 | 5 | 4.3 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cc(F)cc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)C(C)(C)C)C1 | 10.1016/j.bmcl.2014.02.013 | |||
CHEMBL3233190 | 109876 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 577 | 7 | 1 | 5 | 4.3 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cc(F)cc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)C(C)(C)C)C1 | 10.1016/j.bmcl.2014.02.013 | |||
10240064 | 188535 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 599 | 10 | 2 | 6 | 4.6 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL502247 | 188535 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 599 | 10 | 2 | 6 | 4.6 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
10129192 | 188566 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 599 | 11 | 2 | 6 | 4.6 | CCN(CC)[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)[C@H](CS(=O)(=O)c2ccc(SC)cc2)C1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL502793 | 188566 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 599 | 11 | 2 | 6 | 4.6 | CCN(CC)[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)[C@H](CS(=O)(=O)c2ccc(SC)cc2)C1 | 10.1016/j.bmcl.2009.05.041 | |||
91884571 | 181566 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 471 | 5 | 3 | 5 | 2.5 | CC(=O)N[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1N1CC[C@H](NC(=O)c2cccc(C(C)(C)C)n2)C1=O | 10.1021/acsmedchemlett.1c00082 | |||
CHEMBL4764460 | 181566 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 471 | 5 | 3 | 5 | 2.5 | CC(=O)N[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1N1CC[C@H](NC(=O)c2cccc(C(C)(C)C)n2)C1=O | 10.1021/acsmedchemlett.1c00082 | |||
10144709 | 166980 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 574 | 6 | 2 | 3 | 6.7 | CC(C)(O)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)C1 | 10.1016/j.bmcl.2007.12.029 | |||
CHEMBL428602 | 166980 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 574 | 6 | 2 | 3 | 6.7 | CC(C)(O)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)C1 | 10.1016/j.bmcl.2007.12.029 | |||
44425245 | 85810 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 608 | 7 | 2 | 5 | 6.9 | C[C@H]1CN(CCC(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2csc(N)n2)CCC12C=Cc1ccccc12 | 10.1016/j.bmcl.2006.10.059 | |||
CHEMBL229316 | 85810 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 608 | 7 | 2 | 5 | 6.9 | C[C@H]1CN(CCC(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2csc(N)n2)CCC12C=Cc1ccccc12 | 10.1016/j.bmcl.2006.10.059 | |||
44425281 | 153335 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 612 | 9 | 4 | 5 | 6.2 | N=C(N)Nc1nc(C(CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
CHEMBL397749 | 153335 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 612 | 9 | 4 | 5 | 6.2 | N=C(N)Nc1nc(C(CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
11606411 | 85342 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 550 | 4 | 1 | 2 | 7.2 | C[C@H]1CN([C@@H]2CC[C@](C)(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC[C@@]12C=Cc1ccccc12 | 10.1021/jm070166b | |||
CHEMBL226066 | 85342 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 550 | 4 | 1 | 2 | 7.2 | C[C@H]1CN([C@@H]2CC[C@](C)(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC[C@@]12C=Cc1ccccc12 | 10.1021/jm070166b | |||
11598 | 673 | None | 13 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 506 | 6 | 2 | 6 | 3.4 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1016/j.ejmech.2020.112736 | |||
23725177 | 673 | None | 13 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 506 | 6 | 2 | 6 | 3.4 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1016/j.ejmech.2020.112736 | |||
CHEMBL4442783 | 673 | None | 13 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 506 | 6 | 2 | 6 | 3.4 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 10.1016/j.ejmech.2020.112736 | |||
57335017 | 70362 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 595 | 8 | 4 | 6 | 2.8 | N[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N2CCC2)C[C@@H]1CS(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2011.12.057 | |||
CHEMBL1944776 | 70362 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 595 | 8 | 4 | 6 | 2.8 | N[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N2CCC2)C[C@@H]1CS(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2011.12.057 | |||
10175425 | 193642 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 614 | 10 | 3 | 7 | 4.2 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL526752 | 193642 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 614 | 10 | 3 | 7 | 4.2 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
155531379 | 171708 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 532 | 7 | 1 | 5 | 2.6 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](N(C)S(C)(=O)=O)C1 | 10.1021/acsmedchemlett.8b00439 | |||
CHEMBL4465351 | 171708 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 532 | 7 | 1 | 5 | 2.6 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](N(C)S(C)(=O)=O)C1 | 10.1021/acsmedchemlett.8b00439 | |||
44454820 | 97943 | None | 7 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 528 | 5 | 1 | 2 | 7.0 | CC(C)[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.016 | |||
CHEMBL272369 | 97943 | None | 7 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 528 | 5 | 1 | 2 | 7.0 | CC(C)[C@]1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2008.01.016 | |||
44425293 | 153553 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 636 | 8 | 2 | 5 | 7.0 | CC(=O)Nc1nc([C@H](CCN2CCC3(C=Cc4ccccc43)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
CHEMBL397948 | 153553 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 636 | 8 | 2 | 5 | 7.0 | CC(=O)Nc1nc([C@H](CCN2CCC3(C=Cc4ccccc43)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
44423283 | 85341 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 536 | 4 | 1 | 2 | 6.8 | C[C@H]1CN([C@@H]2CC[C@H](C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC[C@@]12C=Cc1ccccc12 | 10.1021/jm070166b | |||
CHEMBL226065 | 85341 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 536 | 4 | 1 | 2 | 6.8 | C[C@H]1CN([C@@H]2CC[C@H](C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC[C@@]12C=Cc1ccccc12 | 10.1021/jm070166b | |||
44593563 | 193219 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 508 | 7 | 2 | 3 | 5.9 | CCC1COCCC1N[C@@H]1CC[C@@](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(C(C)C)C1 | 10.1007/s00044-010-9501-4 | |||
CHEMBL522688 | 193219 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 508 | 7 | 2 | 3 | 5.9 | CCC1COCCC1N[C@@H]1CC[C@@](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(C(C)C)C1 | 10.1007/s00044-010-9501-4 | |||
44593562 | 187601 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 494 | 6 | 2 | 3 | 5.6 | CC1COCCC1N[C@@H]1CC[C@@](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(C(C)C)C1 | 10.1016/j.bmcl.2008.12.050 | |||
CHEMBL494191 | 187601 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 494 | 6 | 2 | 3 | 5.6 | CC1COCCC1N[C@@H]1CC[C@@](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(C(C)C)C1 | 10.1016/j.bmcl.2008.12.050 | |||
71768865 | 111185 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 499 | 3 | 0 | 4 | 4.8 | O=C(N1CCc2ncc(C(F)(F)F)cc2C1)[C@@]12CCO[C@@H]1C[C@@H](N1CCC(c3ccccc3)CC1)C2 | 10.1016/j.bmcl.2014.03.036 | |||
CHEMBL3263282 | 111185 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 499 | 3 | 0 | 4 | 4.8 | O=C(N1CCc2ncc(C(F)(F)F)cc2C1)[C@@]12CCO[C@@H]1C[C@@H](N1CCC(c3ccccc3)CC1)C2 | 10.1016/j.bmcl.2014.03.036 | |||
162666730 | 182380 | None | 1 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 589 | 9 | 2 | 6 | 6.5 | N#CSCCNC(=O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
CHEMBL4783861 | 182380 | None | 1 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 589 | 9 | 2 | 6 | 6.5 | N#CSCCNC(=O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
162656188 | 181021 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 429 | 5 | 3 | 5 | 1.4 | CN[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(C)(C)C)n3)C2=O)[C@H](NC(C)=O)C1 | 10.1021/acsmedchemlett.1c00082 | |||
CHEMBL4757857 | 181021 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 429 | 5 | 3 | 5 | 1.4 | CN[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(C)(C)C)n3)C2=O)[C@H](NC(C)=O)C1 | 10.1021/acsmedchemlett.1c00082 | |||
24794583 | 181199 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 464 | 5 | 3 | 6 | 2.3 | CN[C@@H]1CC[C@H](N2CC[C@H](Nc3ncnc4ccc(C(F)(F)F)cc34)C2=O)[C@H](NC(C)=O)C1 | 10.1021/acsmedchemlett.1c00082 | |||
CHEMBL4760098 | 181199 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 464 | 5 | 3 | 6 | 2.3 | CN[C@@H]1CC[C@H](N2CC[C@H](Nc3ncnc4ccc(C(F)(F)F)cc34)C2=O)[C@H](NC(C)=O)C1 | 10.1021/acsmedchemlett.1c00082 | |||
44425254 | 142347 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 636 | 8 | 2 | 5 | 7.0 | CC(=O)Nc1nc(C(CCN2CCC3(C=Cc4ccccc43)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
CHEMBL388487 | 142347 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 636 | 8 | 2 | 5 | 7.0 | CC(=O)Nc1nc(C(CCN2CCC3(C=Cc4ccccc43)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
16066354 | 121299 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 567 | 9 | 3 | 4 | 5.2 | CCC[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)C1=O | 10.1021/ml500505q | |||
CHEMBL3577943 | 121299 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 567 | 9 | 3 | 4 | 5.2 | CCC[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)C1=O | 10.1021/ml500505q | |||
122178128 | 121296 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 503 | 9 | 2 | 3 | 5.1 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)[C@H](CCc2ccccc2)C1 | 10.1021/ml500505q | |||
CHEMBL3577940 | 121296 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 503 | 9 | 2 | 3 | 5.1 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)[C@H](CCc2ccccc2)C1 | 10.1021/ml500505q | |||
42606792 | 109864 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 517 | 7 | 1 | 5 | 3.0 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](CS(C)(=O)=O)C1 | 10.1016/j.bmcl.2014.02.013 | |||
CHEMBL3233178 | 109864 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 517 | 7 | 1 | 5 | 3.0 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](CS(C)(=O)=O)C1 | 10.1016/j.bmcl.2014.02.013 | |||
42606792 | 109864 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 517 | 7 | 1 | 5 | 3.0 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](CS(C)(=O)=O)C1 | 10.1021/acsmedchemlett.8b00439 | |||
CHEMBL3233178 | 109864 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 517 | 7 | 1 | 5 | 3.0 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](CS(C)(=O)=O)C1 | 10.1021/acsmedchemlett.8b00439 | |||
44425250 | 86086 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 630 | 9 | 2 | 5 | 6.9 | CC(=O)Nc1nc(C(CCN2CCC(c3ccc(F)cc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
CHEMBL230790 | 86086 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 630 | 9 | 2 | 5 | 6.9 | CC(=O)Nc1nc(C(CCN2CCC(c3ccc(F)cc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
16216716 | 153618 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 612 | 9 | 2 | 5 | 6.8 | CC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
CHEMBL397996 | 153618 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 612 | 9 | 2 | 5 | 6.8 | CC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
22143255 | 187964 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 523 | 7 | 4 | 6 | 2.4 | CSc1ccc(C(=O)NC2CCN(C)CC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL496343 | 187964 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 523 | 7 | 4 | 6 | 2.4 | CSc1ccc(C(=O)NC2CCN(C)CC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
11753466 | 77669 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 575 | 8 | 2 | 6 | 4.5 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)Cc2nc3cccc(C(F)(F)F)c3[nH]2)[C@H](CS(=O)(=O)c2ccc(C#N)cc2)C1 | 10.1016/j.bmcl.2012.08.002 | |||
CHEMBL2088380 | 77669 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 575 | 8 | 2 | 6 | 4.5 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)Cc2nc3cccc(C(F)(F)F)c3[nH]2)[C@H](CS(=O)(=O)c2ccc(C#N)cc2)C1 | 10.1016/j.bmcl.2012.08.002 | |||
69035677 | 77678 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 590 | 8 | 1 | 5 | 5.6 | CCN(C(C)C)[C@@H]1CC[C@H](N2CCC(c3nc4cccc(C(F)(F)F)c4[nH]3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2012.08.002 | |||
CHEMBL2088389 | 77678 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 590 | 8 | 1 | 5 | 5.6 | CCN(C(C)C)[C@@H]1CC[C@H](N2CCC(c3nc4cccc(C(F)(F)F)c4[nH]3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2012.08.002 | |||
155529593 | 171558 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 518 | 7 | 2 | 5 | 2.2 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](NS(C)(=O)=O)C1 | 10.1021/acsmedchemlett.8b00439 | |||
CHEMBL4463290 | 171558 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 518 | 7 | 2 | 5 | 2.2 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](NS(C)(=O)=O)C1 | 10.1021/acsmedchemlett.8b00439 | |||
44425652 | 168871 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 526 | 5 | 1 | 2 | 6.7 | C[C@H]1CN([C@@H]2CC[C@@](C(=O)NCc3cc(F)cc(C(F)(F)F)c3)(C3CC3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2007.04.053 | |||
CHEMBL437359 | 168871 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 526 | 5 | 1 | 2 | 6.7 | C[C@H]1CN([C@@H]2CC[C@@](C(=O)NCc3cc(F)cc(C(F)(F)F)c3)(C3CC3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2007.04.053 | |||
50925394 | 19335 | None | 0 | Mouse | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 517 | 8 | 2 | 4 | 4.4 | CCO[C@H]1CN([C@H]2CC[C@@H](c3ccccc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.10.020 | |||
CHEMBL1290636 | 19335 | None | 0 | Mouse | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 517 | 8 | 2 | 4 | 4.4 | CCO[C@H]1CN([C@H]2CC[C@@H](c3ccccc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.10.020 | |||
52941377 | 19336 | None | 0 | Mouse | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 531 | 9 | 2 | 4 | 4.8 | CCCO[C@H]1CN([C@H]2CC[C@@H](c3ccccc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.10.020 | |||
CHEMBL1290637 | 19336 | None | 0 | Mouse | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 531 | 9 | 2 | 4 | 4.8 | CCCO[C@H]1CN([C@H]2CC[C@@H](c3ccccc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.10.020 | |||
68004034 | 86616 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 506 | 6 | 3 | 8 | 3.1 | O=C(CNc1ncnc2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@](O)(c3nccs3)CC2)C1 | 10.1016/j.bmcl.2012.12.017 | |||
CHEMBL2315922 | 86616 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 506 | 6 | 3 | 8 | 3.1 | O=C(CNc1ncnc2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@](O)(c3nccs3)CC2)C1 | 10.1016/j.bmcl.2012.12.017 | |||
76315270 | 84934 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 576 | 9 | 2 | 7 | 4.4 | CCO[C@@H]1CN([C@H]2CC[C@@](O)(c3ccc4c(c3)OCO4)CC2)C[C@@H]1NC(=O)CCC(=O)c1cccc(C(F)(F)F)c1 | 10.1007/s00044-010-9497-9 | |||
CHEMBL2236474 | 84934 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 576 | 9 | 2 | 7 | 4.4 | CCO[C@@H]1CN([C@H]2CC[C@@](O)(c3ccc4c(c3)OCO4)CC2)C[C@@H]1NC(=O)CCC(=O)c1cccc(C(F)(F)F)c1 | 10.1007/s00044-010-9497-9 | |||
162666730 | 182380 | None | 1 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 589 | 9 | 2 | 6 | 6.5 | N#CSCCNC(=O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
CHEMBL4783861 | 182380 | None | 1 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 589 | 9 | 2 | 6 | 6.5 | N#CSCCNC(=O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
53389845 | 173064 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 315 | 3 | 2 | 5 | 2.1 | Nc1nc2[nH]c(C3CC3)c(Cc3cccc(Cl)c3)c(=O)n2n1 | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4517518 | 173064 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 315 | 3 | 2 | 5 | 2.1 | Nc1nc2[nH]c(C3CC3)c(Cc3cccc(Cl)c3)c(=O)n2n1 | 10.1021/acs.jmedchem.9b00742 | |||
11663882 | 95164 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 541 | 7 | 2 | 4 | 5.1 | COc1cccc2c(C3CCN(C(CO)C4CCN(C(=O)/C=C/c5cc(F)c(F)c(F)c5)CC4)CC3)c[nH]c12 | 10.1016/j.bmcl.2008.05.010 | |||
CHEMBL255500 | 95164 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 541 | 7 | 2 | 4 | 5.1 | COc1cccc2c(C3CCN(C(CO)C4CCN(C(=O)/C=C/c5cc(F)c(F)c(F)c5)CC4)CC3)c[nH]c12 | 10.1016/j.bmcl.2008.05.010 | |||
11713221 | 95654 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 511 | 6 | 2 | 3 | 5.1 | O=C(/C=C/c1cc(F)c(F)c(F)c1)N1CCC([C@H](CO)N2CCC(c3c[nH]c4ccccc34)CC2)CC1 | 10.1016/j.bmcl.2008.05.010 | |||
CHEMBL257768 | 95654 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 511 | 6 | 2 | 3 | 5.1 | O=C(/C=C/c1cc(F)c(F)c(F)c1)N1CCC([C@H](CO)N2CCC(c3c[nH]c4ccccc34)CC2)CC1 | 10.1016/j.bmcl.2008.05.010 | |||
11606147 | 155433 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 525 | 6 | 2 | 3 | 5.7 | O=C(/C=C/c1cccc(C(F)(F)F)c1)N1CCC(C(CO)N2CCC(c3c[nH]c4ccccc34)CC2)CC1 | 10.1016/j.bmcl.2008.05.010 | |||
CHEMBL403250 | 155433 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 525 | 6 | 2 | 3 | 5.7 | O=C(/C=C/c1cccc(C(F)(F)F)c1)N1CCC(C(CO)N2CCC(c3c[nH]c4ccccc34)CC2)CC1 | 10.1016/j.bmcl.2008.05.010 | |||
44448807 | 155488 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 558 | 6 | 4 | 4 | 5.7 | O=C(O)c1ccc2[nH]cc(C3CCN(C(CO)C4CCN(C(=O)Nc5ccc(Cl)c(Cl)c5)CC4)CC3)c2c1 | 10.1016/j.bmcl.2008.05.010 | |||
CHEMBL403581 | 155488 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 558 | 6 | 4 | 4 | 5.7 | O=C(O)c1ccc2[nH]cc(C3CCN(C(CO)C4CCN(C(=O)Nc5ccc(Cl)c(Cl)c5)CC4)CC3)c2c1 | 10.1016/j.bmcl.2008.05.010 | |||
57656715 | 75232 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 410 | 4 | 1 | 3 | 4.0 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(C[C@@H]2CCCN(C3CC3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036757 | 75232 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 410 | 4 | 1 | 3 | 4.0 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCN(C[C@@H]2CCCN(C3CC3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
70693849 | 73757 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 491 | 11 | 5 | 5 | 4.0 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNc1n[nH]c2ccc(C(F)(F)F)cc12 | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018395 | 73757 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 491 | 11 | 5 | 5 | 4.0 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNc1n[nH]c2ccc(C(F)(F)F)cc12 | 10.1016/j.bmcl.2012.03.007 | |||
49763682 | 65442 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 489 | 7 | 2 | 4 | 4.0 | COc1ccc([C@H]2CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cc1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829612 | 65442 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 489 | 7 | 2 | 4 | 4.0 | COc1ccc([C@H]2CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cc1 | 10.1016/j.bmcl.2011.06.080 | |||
44441352 | 93436 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 509 | 7 | 1 | 2 | 6.8 | C[N+](C)(Cc1ccc(NC(=O)/C=C/c2ccc(-c3ccc(C(F)(F)F)cc3)cc2)cc1)C1CCOCC1 | 10.1016/j.bmcl.2007.01.115 | |||
CHEMBL245686 | 93436 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 509 | 7 | 1 | 2 | 6.8 | C[N+](C)(Cc1ccc(NC(=O)/C=C/c2ccc(-c3ccc(C(F)(F)F)cc3)cc2)cc1)C1CCOCC1 | 10.1016/j.bmcl.2007.01.115 | |||
44441347 | 93845 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 455 | 7 | 1 | 2 | 6.1 | Cc1ccc(-c2ccc(/C=C/C(=O)Nc3ccc(C[N+](C)(C)C4CCOCC4)cc3)cc2)cc1 | 10.1016/j.bmcl.2007.01.115 | |||
CHEMBL247537 | 93845 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 455 | 7 | 1 | 2 | 6.1 | Cc1ccc(-c2ccc(/C=C/C(=O)Nc3ccc(C[N+](C)(C)C4CCOCC4)cc3)cc2)cc1 | 10.1016/j.bmcl.2007.01.115 | |||
44425631 | 142162 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 564 | 5 | 1 | 2 | 7.6 | CCC1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCC(N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2007.04.053 | |||
CHEMBL388007 | 142162 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 564 | 5 | 1 | 2 | 7.6 | CCC1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCC(N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2007.04.053 | |||
44413089 | 77936 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 459 | 8 | 1 | 3 | 5.1 | CN(C)CC/C=N/[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2006.04.045 | |||
CHEMBL209411 | 77936 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 459 | 8 | 1 | 3 | 5.1 | CN(C)CC/C=N/[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2006.04.045 | |||
11319072 | 74568 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4cncnc4)cn3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
CHEMBL2029420 | 74568 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4cncnc4)cn3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
11330837 | 74577 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 596 | 6 | 2 | 9 | 3.6 | O=C(C1CCN(c2cc(C(F)(F)F)ncn2)CC1)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncccn4)cn3)CC2)C1 | 10.1021/ml200199c | |||
CHEMBL2029570 | 74577 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 596 | 6 | 2 | 9 | 3.6 | O=C(C1CCN(c2cc(C(F)(F)F)ncn2)CC1)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccc(-c4ncccn4)cn3)CC2)C1 | 10.1021/ml200199c | |||
11756884 | 19096 | None | 0 | Mouse | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 533 | 8 | 3 | 5 | 3.5 | CCO[C@H]1CN([C@H]2CC[C@@](O)(c3ccccc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.10.020 | |||
CHEMBL1289083 | 19096 | None | 0 | Mouse | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 533 | 8 | 3 | 5 | 3.5 | CCO[C@H]1CN([C@H]2CC[C@@](O)(c3ccccc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.10.020 | |||
11562947 | 89860 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 544 | 6 | 3 | 4 | 5.6 | O=C(O)C(C1CCN(C(=O)Nc2ccc(OC(F)(F)F)cc2)CC1)N1CCC(c2c[nH]c3ccccc23)CC1 | 10.1021/jm070902b | |||
CHEMBL237754 | 89860 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 544 | 6 | 3 | 4 | 5.6 | O=C(O)C(C1CCN(C(=O)Nc2ccc(OC(F)(F)F)cc2)CC1)N1CCC(c2c[nH]c3ccccc23)CC1 | 10.1021/jm070902b | |||
12093170 | 872 | None | 34 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 351 | 3 | 1 | 3 | 4.2 | Clc1ccc(c(c1)F)N1[C@H](C2CCCCC2)C(=C(C1=O)O)C(=O)C | 10.1021/acs.jmedchem.6b01309 | |||
9431 | 872 | None | 34 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 351 | 3 | 1 | 3 | 4.2 | Clc1ccc(c(c1)F)N1[C@H](C2CCCCC2)C(=C(C1=O)O)C(=O)C | 10.1021/acs.jmedchem.6b01309 | |||
CHEMBL4519152 | 872 | None | 34 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 351 | 3 | 1 | 3 | 4.2 | Clc1ccc(c(c1)F)N1[C@H](C2CCCCC2)C(=C(C1=O)O)C(=O)C | 10.1021/acs.jmedchem.6b01309 | |||
10008367 | 2022 | None | 36 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 577 | 8 | 3 | 7 | 3.2 | CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@@H]1CC[C@](CC1)(O)c1ccc2c(c1)OCO2 | 10.1021/acs.jmedchem.6b01309 | |||
777 | 2022 | None | 36 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 577 | 8 | 3 | 7 | 3.2 | CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@@H]1CC[C@](CC1)(O)c1ccc2c(c1)OCO2 | 10.1021/acs.jmedchem.6b01309 | |||
CHEMBL1289316 | 2022 | None | 36 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 577 | 8 | 3 | 7 | 3.2 | CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@@H]1CC[C@](CC1)(O)c1ccc2c(c1)OCO2 | 10.1021/acs.jmedchem.6b01309 | |||
CHEMBL2426341 | 2022 | None | 36 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 577 | 8 | 3 | 7 | 3.2 | CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@@H]1CC[C@](CC1)(O)c1ccc2c(c1)OCO2 | 10.1021/acs.jmedchem.6b01309 | |||
CHEMBL5268600 | 2022 | None | 36 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 577 | 8 | 3 | 7 | 3.2 | CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@@H]1CC[C@](CC1)(O)c1ccc2c(c1)OCO2 | 10.1021/acs.jmedchem.6b01309 | |||
57395216 | 71036 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 491 | 6 | 3 | 6 | 2.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN([C@H]2CC[C@@](O)(c3ncccn3)CC2)C1 | 10.1021/ml200030q | |||
CHEMBL1951771 | 71036 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 491 | 6 | 3 | 6 | 2.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN([C@H]2CC[C@@](O)(c3ncccn3)CC2)C1 | 10.1021/ml200030q | |||
53322809 | 58474 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 481 | 5 | 1 | 4 | 4.6 | CC(C)[C@]1(C(=O)N2CCN(c3cccc(C(F)(F)F)c3)CC2)CC[C@@H](N[C@@H]2CCOC[C@@H]2C)C1 | 10.1016/j.bmcl.2011.01.015 | |||
CHEMBL1683060 | 58474 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 481 | 5 | 1 | 4 | 4.6 | CC(C)[C@]1(C(=O)N2CCN(c3cccc(C(F)(F)F)c3)CC2)CC[C@@H](N[C@@H]2CCOC[C@@H]2C)C1 | 10.1016/j.bmcl.2011.01.015 | |||
53321483 | 58492 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 498 | 7 | 1 | 6 | 3.5 | CCC[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)CC[C@@H](N[C@H]2CCOC[C@H]2OC)C1 | 10.1016/j.bmcl.2011.01.015 | |||
CHEMBL1683078 | 58492 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 498 | 7 | 1 | 6 | 3.5 | CCC[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)CC[C@@H](N[C@H]2CCOC[C@H]2OC)C1 | 10.1016/j.bmcl.2011.01.015 | |||
57391766 | 71041 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 491 | 6 | 3 | 6 | 2.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN([C@H]2CC[C@@](O)(c3cnccn3)CC2)C1 | 10.1021/ml200030q | |||
CHEMBL1951776 | 71041 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 491 | 6 | 3 | 6 | 2.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN([C@H]2CC[C@@](O)(c3cnccn3)CC2)C1 | 10.1021/ml200030q | |||
162658125 | 181202 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 471 | 6 | 2 | 4 | 5.9 | O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
CHEMBL4760108 | 181202 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 471 | 6 | 2 | 4 | 5.9 | O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
10184250 | 73728 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 479 | 10 | 4 | 4 | 3.3 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)[C@H](O)C(C)C)c(C)c1 | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018365 | 73728 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 479 | 10 | 4 | 4 | 3.3 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)[C@H](O)C(C)C)c(C)c1 | 10.1016/j.bmcl.2012.03.007 | |||
10186010 | 73737 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 513 | 10 | 4 | 4 | 4.1 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)[C@@H](O)c2ccccc2)c(C)c1 | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018375 | 73737 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 513 | 10 | 4 | 4 | 4.1 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)[C@@H](O)c2ccccc2)c(C)c1 | 10.1016/j.bmcl.2012.03.007 | |||
46241120 | 83609 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 481 | 6 | 3 | 5 | 3.1 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@@](O)(c3cccs3)CC2)C1 | 10.1021/ml300260s | |||
CHEMBL2204258 | 83609 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 481 | 6 | 3 | 5 | 3.1 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@@](O)(c3cccs3)CC2)C1 | 10.1021/ml300260s | |||
44442557 | 155015 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 504 | 10 | 4 | 4 | 3.0 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(=O)NC2(C)CC2)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL401010 | 155015 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 504 | 10 | 4 | 4 | 3.0 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(=O)NC2(C)CC2)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
781 | 3396 | None | 52 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 417 | 4 | 1 | 5 | 5.1 | O=C1Nc2ccc(cc2C2(O1)CCN(CC2)CCc1nc(oc1C)c1ccccc1)C | 10.1021/acs.jmedchem.6b01309 | |||
9953769 | 3396 | None | 52 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 417 | 4 | 1 | 5 | 5.1 | O=C1Nc2ccc(cc2C2(O1)CCN(CC2)CCc1nc(oc1C)c1ccccc1)C | 10.1021/acs.jmedchem.6b01309 | |||
CHEMBL134074 | 3396 | None | 52 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 417 | 4 | 1 | 5 | 5.1 | O=C1Nc2ccc(cc2C2(O1)CCN(CC2)CCc1nc(oc1C)c1ccccc1)C | 10.1021/acs.jmedchem.6b01309 | |||
10436045 | 3516 | None | 4 | Human | Binding | pIC50 | = | 7 | 7.0 | -85 | 13 | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.6b01309 | |||
782 | 3516 | None | 4 | Human | Binding | pIC50 | = | 7 | 7.0 | -85 | 13 | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.6b01309 | |||
CHEMBL432713 | 3516 | None | 4 | Human | Binding | pIC50 | = | 7 | 7.0 | -85 | 13 | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1021/acs.jmedchem.6b01309 | |||
89823342 | 126427 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 492 | 4 | 1 | 5 | 3.9 | C[C@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2C[C@@H]3C[C@H]2CN3c2cc(C(F)(F)F)ccn2)C1 | nan | |||
CHEMBL3650405 | 126427 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 492 | 4 | 1 | 5 | 3.9 | C[C@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2C[C@@H]3C[C@H]2CN3c2cc(C(F)(F)F)ccn2)C1 | nan | |||
56680600 | 65438 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 501 | 6 | 2 | 5 | 3.6 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN(C2CC=C(c3ccc4c(c3)OCO4)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829607 | 65438 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 501 | 6 | 2 | 5 | 3.6 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN(C2CC=C(c3ccc4c(c3)OCO4)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
44413167 | 79750 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 447 | 8 | 2 | 3 | 4.2 | CN(C)CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2006.04.045 | |||
CHEMBL211560 | 79750 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 447 | 8 | 2 | 3 | 4.2 | CN(C)CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2006.04.045 | |||
46842232 | 7884 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 544 | 8 | 2 | 4 | 3.9 | Cc1ccc(C(=O)N2CCC(CCN3CC[C@@H](NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cc1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1089965 | 7884 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 544 | 8 | 2 | 4 | 3.9 | Cc1ccc(C(=O)N2CCC(CCN3CC[C@@H](NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cc1 | 10.1016/j.bmcl.2010.02.072 | |||
10161975 | 94013 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 465 | 9 | 3 | 5 | 2.5 | COC(=O)[C@@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL248416 | 94013 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 465 | 9 | 3 | 5 | 2.5 | COC(=O)[C@@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.07.028 | |||
11843945 | 78081 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 504 | 8 | 1 | 2 | 6.5 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCCN1CCCCC1)c1ccc(F)cc1 | 10.1021/jm060439n | |||
CHEMBL209975 | 78081 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 504 | 8 | 1 | 2 | 6.5 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCCN1CCCCC1)c1ccc(F)cc1 | 10.1021/jm060439n | |||
5481702 | 208281 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 556 | 8 | 0 | 4 | 5.3 | CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1 | 10.1016/s0960-894x(00)00639-9 | |||
CHEMBL83338 | 208281 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 556 | 8 | 0 | 4 | 5.3 | CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1 | 10.1016/s0960-894x(00)00639-9 | |||
56672021 | 65636 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 433 | 5 | 2 | 5 | 3.0 | C#C[C@H]1CC[C@@H](N2CC(NC(=O)CNc3nn(C)c4ccc(C(F)(F)F)cc34)C2)CC1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1833983 | 65636 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 433 | 5 | 2 | 5 | 3.0 | C#C[C@H]1CC[C@@H](N2CC(NC(=O)CNc3nn(C)c4ccc(C(F)(F)F)cc34)C2)CC1 | 10.1016/j.bmcl.2011.08.074 | |||
44453208 | 169525 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 385 | 6 | 2 | 3 | 2.8 | Cc1ccc(C(=O)NCC(=O)N[C@@H]2CCN(Cc3ccc(Cl)cc3)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL442451 | 169525 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 385 | 6 | 2 | 3 | 2.8 | Cc1ccc(C(=O)NCC(=O)N[C@@H]2CCN(Cc3ccc(Cl)cc3)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
11329244 | 71140 | None | 6 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 486 | 7 | 2 | 5 | 5.4 | CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1021/jm049530m | |||
CHEMBL195433 | 71140 | None | 6 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 486 | 7 | 2 | 5 | 5.4 | CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1021/jm049530m | |||
11272103 | 124442 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | |||
CHEMBL363840 | 124442 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | |||
44353447 | 3775 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 1 | ChEMBL | 433 | 6 | 2 | 3 | 3.4 | O=C(N[C@@H]1CCN(C1)Cc1ccc(cc1C)C)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/acs.jmedchem.6b01309 | |||
785 | 3775 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 1 | ChEMBL | 433 | 6 | 2 | 3 | 3.4 | O=C(N[C@@H]1CCN(C1)Cc1ccc(cc1C)C)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/acs.jmedchem.6b01309 | |||
CHEMBL337246 | 3775 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 1 | ChEMBL | 433 | 6 | 2 | 3 | 3.4 | O=C(N[C@@H]1CCN(C1)Cc1ccc(cc1C)C)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/acs.jmedchem.6b01309 | |||
11227368 | 77672 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 618 | 9 | 2 | 5 | 6.2 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)Cc2nc3cccc(C(F)(F)F)c3[nH]2)[C@H](CS(=O)(=O)c2ccc(C3CCCC3)cc2)C1 | 10.1016/j.bmcl.2012.08.002 | |||
CHEMBL2088383 | 77672 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 618 | 9 | 2 | 5 | 6.2 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)Cc2nc3cccc(C(F)(F)F)c3[nH]2)[C@H](CS(=O)(=O)c2ccc(C3CCCC3)cc2)C1 | 10.1016/j.bmcl.2012.08.002 | |||
25267730 | 148337 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 421 | 6 | 1 | 2 | 5.2 | C[N+](C)(Cc1ccc(NC(=O)c2ccc(Cl)c(Cl)c2)cc1)CC1CCOCC1 | 10.1016/j.bmcl.2007.01.115 | |||
CHEMBL393632 | 148337 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 421 | 6 | 1 | 2 | 5.2 | C[N+](C)(Cc1ccc(NC(=O)c2ccc(Cl)c(Cl)c2)cc1)CC1CCOCC1 | 10.1016/j.bmcl.2007.01.115 | |||
9885683 | 18954 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 369 | 3 | 1 | 4 | 3.9 | O=C(O)c1cc2ccccc2n1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2003.10.049 | |||
CHEMBL128640 | 18954 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 369 | 3 | 1 | 4 | 3.9 | O=C(O)c1cc2ccccc2n1S(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2003.10.049 | |||
89823584 | 126396 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 537 | 6 | 1 | 6 | 3.8 | COc1ccc(N2C[C@@H]3C[C@H]2CN3C(=O)[C@@]23CCC[C@@H]2C[C@@H](N[C@H]2CCOC[C@H]2OC)C3)cc1C(F)(F)F | nan | |||
CHEMBL3650376 | 126396 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 537 | 6 | 1 | 6 | 3.8 | COc1ccc(N2C[C@@H]3C[C@H]2CN3C(=O)[C@@]23CCC[C@@H]2C[C@@H](N[C@H]2CCOC[C@H]2OC)C3)cc1C(F)(F)F | nan | |||
162658125 | 181202 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 471 | 6 | 2 | 4 | 5.9 | O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
CHEMBL4760108 | 181202 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 471 | 6 | 2 | 4 | 5.9 | O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
44353196 | 20932 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 343 | 3 | 1 | 4 | 4.2 | Clc1ccc(Cn2c(-c3nn[nH]n3)cc3ccccc32)cc1Cl | 10.1016/j.bmcl.2003.10.049 | |||
CHEMBL131087 | 20932 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 343 | 3 | 1 | 4 | 4.2 | Clc1ccc(Cn2c(-c3nn[nH]n3)cc3ccccc32)cc1Cl | 10.1016/j.bmcl.2003.10.049 | |||
10371682 | 73841 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 620 | 11 | 4 | 6 | 5.3 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)N1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2NC(=O)OC(C)(C)C)C1=O | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018541 | 73841 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 620 | 11 | 4 | 6 | 5.3 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)N1CC[C@H](NC(=O)c2cc(C(F)(F)F)ccc2NC(=O)OC(C)(C)C)C1=O | 10.1016/j.bmcl.2012.03.007 | |||
22310939 | 115729 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 387 | 3 | 1 | 2 | 5.7 | O=C(O)c1cc2ccc(C(F)(F)F)cc2n1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2003.10.049 | |||
CHEMBL335378 | 115729 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 387 | 3 | 1 | 2 | 5.7 | O=C(O)c1cc2ccc(C(F)(F)F)cc2n1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2003.10.049 | |||
70681778 | 75243 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 367 | 4 | 1 | 4 | 2.6 | N#Cc1cccc(NC(=O)N2CCN(C[C@@H]3CCCN(C4CC4)C3)CC2)c1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036768 | 75243 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 367 | 4 | 1 | 4 | 2.6 | N#Cc1cccc(NC(=O)N2CCN(C[C@@H]3CCCN(C4CC4)C3)CC2)c1 | 10.1016/j.bmcl.2012.04.118 | |||
89823498 | 126381 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 521 | 5 | 1 | 5 | 4.1 | CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2C[C@@H]3C[C@H]2CN3c2cc(C(F)(F)F)ccc2C)C1 | nan | |||
CHEMBL3650361 | 126381 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 521 | 5 | 1 | 5 | 4.1 | CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2C[C@@H]3C[C@H]2CN3c2cc(C(F)(F)F)ccc2C)C1 | nan | |||
44439169 | 90808 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 622 | 16 | 1 | 5 | 8.8 | CCC(C)CC(CCCN(CC)CC)NC(=O)CCOc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.ejmech.2010.04.024 | |||
CHEMBL239170 | 90808 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 622 | 16 | 1 | 5 | 8.8 | CCC(C)CC(CCCN(CC)CC)NC(=O)CCOc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.ejmech.2010.04.024 | |||
44439169 | 90808 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 622 | 16 | 1 | 5 | 8.8 | CCC(C)CC(CCCN(CC)CC)NC(=O)CCOc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
CHEMBL239170 | 90808 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 622 | 16 | 1 | 5 | 8.8 | CCC(C)CC(CCCN(CC)CC)NC(=O)CCOc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
49863202 | 15218 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 550 | 12 | 1 | 4 | 7.6 | CCN(CC)C(C)CCCNC(=O)CCc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.ejmech.2010.04.024 | |||
CHEMBL1210670 | 15218 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 550 | 12 | 1 | 4 | 7.6 | CCN(CC)C(C)CCCNC(=O)CCc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.ejmech.2010.04.024 | |||
71518728 | 86442 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 481 | 4 | 1 | 5 | 3.7 | COC1COCCC1N[C@@H]1C[C@H]2CCCC[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2012.10.069 | |||
CHEMBL2314065 | 86442 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 481 | 4 | 1 | 5 | 3.7 | COC1COCCC1N[C@@H]1C[C@H]2CCCC[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2012.10.069 | |||
44414578 | 78439 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 566 | 9 | 1 | 2 | 8.2 | C[C@](CCN1CCC(c2ccccc2)CC1)(CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1021/jm060439n | |||
CHEMBL211106 | 78439 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 566 | 9 | 1 | 2 | 8.2 | C[C@](CCN1CCC(c2ccccc2)CC1)(CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccc(F)cc1 | 10.1021/jm060439n | |||
11570431 | 92016 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 564 | 13 | 1 | 4 | 7.9 | CCN(CC)CCCC(C)NC(=O)CCCc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
CHEMBL241502 | 92016 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 564 | 13 | 1 | 4 | 7.9 | CCN(CC)CCCC(C)NC(=O)CCCc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
44353418 | 22545 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 364 | 4 | 1 | 4 | 4.6 | O=C(O)c1cc2cccc([N+](=O)[O-])c2n1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2003.10.049 | |||
CHEMBL132584 | 22545 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 364 | 4 | 1 | 4 | 4.6 | O=C(O)c1cc2cccc([N+](=O)[O-])c2n1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2003.10.049 | |||
71768830 | 111168 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 485 | 4 | 1 | 6 | 3.0 | COC1COCCC1N[C@@H]1C[C@H]2SCC[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2014.03.036 | |||
CHEMBL3263261 | 111168 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 485 | 4 | 1 | 6 | 3.0 | COC1COCCC1N[C@@H]1C[C@H]2SCC[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2014.03.036 | |||
57344302 | 130715 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 554 | 7 | 3 | 4 | 5.3 | CC1(C)Cc2cc(/C=C/C(=O)N3CCC(C(NC4CCC(c5c[nH]c6ccccc56)CC4)C(N)=O)CC3)ccc2O1 | nan | |||
CHEMBL3681893 | 130715 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 554 | 7 | 3 | 4 | 5.3 | CC1(C)Cc2cc(/C=C/C(=O)N3CCC(C(NC4CCC(c5c[nH]c6ccccc56)CC4)C(N)=O)CC3)ccc2O1 | nan | |||
72663455 | 129469 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 469 | 4 | 1 | 6 | 2.3 | COC1COCCC1NC1CC2OCCC2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | nan | |||
CHEMBL3671251 | 129469 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 469 | 4 | 1 | 6 | 2.3 | COC1COCCC1NC1CC2OCCC2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | nan | |||
11753664 | 77651 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 596 | 9 | 2 | 6 | 5.3 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2NC(=O)Cc2nc3cccc(C(F)(F)F)c3[nH]2)cc1 | 10.1016/j.bmcl.2012.08.002 | |||
CHEMBL2088210 | 77651 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 596 | 9 | 2 | 6 | 5.3 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2NC(=O)Cc2nc3cccc(C(F)(F)F)c3[nH]2)cc1 | 10.1016/j.bmcl.2012.08.002 | |||
10207639 | 73838 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 508 | 12 | 4 | 5 | 3.7 | CCC[C@H](OC)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1N | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018538 | 73838 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 508 | 12 | 4 | 5 | 3.7 | CCC[C@H](OC)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(C(F)(F)F)ccc1N | 10.1016/j.bmcl.2012.03.007 | |||
44595711 | 137408 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 332 | 2 | 1 | 1 | 5.1 | C[C@H]1CC=C(C(=O)O)[C@](C)(c2ccc(Cl)c(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2015.11.051 | |||
CHEMBL3752627 | 137408 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 332 | 2 | 1 | 1 | 5.1 | C[C@H]1CC=C(C(=O)O)[C@](C)(c2ccc(Cl)c(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2015.11.051 | |||
53322810 | 58489 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 499 | 6 | 1 | 7 | 2.7 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3nccc(C(F)(F)F)n3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.015 | |||
CHEMBL1683075 | 58489 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 499 | 6 | 1 | 7 | 2.7 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3nccc(C(F)(F)F)n3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.015 | |||
11409228 | 74560 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 490 | 6 | 3 | 5 | 2.9 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccccn3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
CHEMBL2029412 | 74560 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 490 | 6 | 3 | 5 | 2.9 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3ccccn3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
70689914 | 74578 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 552 | 6 | 2 | 9 | 3.0 | N#Cc1ccnc(N2CCC(C(=O)N3CC[C@H](N[C@H]4CC[C@@](O)(c5ccc(-c6ncccn6)cn5)CC4)C3)CC2)c1 | 10.1021/ml200199c | |||
CHEMBL2029571 | 74578 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 552 | 6 | 2 | 9 | 3.0 | N#Cc1ccnc(N2CCC(C(=O)N3CC[C@H](N[C@H]4CC[C@@](O)(c5ccc(-c6ncccn6)cn5)CC4)C3)CC2)c1 | 10.1021/ml200199c | |||
44453440 | 97741 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 448 | 7 | 3 | 4 | 3.0 | CCc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL271288 | 97741 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 448 | 7 | 3 | 4 | 3.0 | CCc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
10142792 | 93794 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 521 | 9 | 5 | 5 | 2.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL247245 | 93794 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 521 | 9 | 5 | 5 | 2.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
71768689 | 111174 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 469 | 4 | 1 | 6 | 2.3 | CO[C@H]1COCC[C@H]1N[C@@H]1C[C@H]2OCC[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2014.03.036 | |||
CHEMBL3263269 | 111174 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 469 | 4 | 1 | 6 | 2.3 | CO[C@H]1COCC[C@H]1N[C@@H]1C[C@H]2OCC[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2014.03.036 | |||
53319664 | 58694 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 461 | 6 | 1 | 5 | 2.6 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2C[C@@H]3C[C@H]2CN3C(=O)C2CCCC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.052 | |||
CHEMBL1684700 | 58694 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 461 | 6 | 1 | 5 | 2.6 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2C[C@@H]3C[C@H]2CN3C(=O)C2CCCC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.052 | |||
23630215 | 62564 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 508 | 5 | 1 | 5 | 4.3 | CC(C)[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)CC[C@@H](NC2C3CCCC2COC3)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782376 | 62564 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 508 | 5 | 1 | 5 | 4.3 | CC(C)[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)CC[C@@H](NC2C3CCCC2COC3)C1 | 10.1016/j.bmcl.2011.01.034 | |||
53321482 | 58478 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 495 | 6 | 1 | 4 | 5.0 | CC[C@H]1COCC[C@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cccc(C(F)(F)F)c3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.015 | |||
CHEMBL1683064 | 58478 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 495 | 6 | 1 | 4 | 5.0 | CC[C@H]1COCC[C@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cccc(C(F)(F)F)c3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.015 | |||
53318314 | 58688 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 445 | 5 | 1 | 4 | 3.3 | CC(C)[C@]1(C(=O)N2C[C@@H]3C[C@H]2CN3C(=O)C2CCCCC2)CC[C@@H](NC2CCOCC2)C1 | 10.1016/j.bmcl.2011.01.052 | |||
CHEMBL1684692 | 58688 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 445 | 5 | 1 | 4 | 3.3 | CC(C)[C@]1(C(=O)N2C[C@@H]3C[C@H]2CN3C(=O)C2CCCCC2)CC[C@@H](NC2CCOCC2)C1 | 10.1016/j.bmcl.2011.01.052 | |||
53323654 | 58693 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 447 | 6 | 1 | 5 | 2.2 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2C[C@@H]3C[C@H]2CN3C(=O)C2CCC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.052 | |||
CHEMBL1684699 | 58693 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 447 | 6 | 1 | 5 | 2.2 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2C[C@@H]3C[C@H]2CN3C(=O)C2CCC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.052 | |||
72947191 | 105316 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 600 | 7 | 1 | 6 | 3.6 | COC1COCCC1N[C@@H]1C[C@H]2CN(C(=O)CCc3ccccc3)C[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2013.05.024 | |||
CHEMBL3115275 | 105316 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 600 | 7 | 1 | 6 | 3.6 | COC1COCCC1N[C@@H]1C[C@H]2CN(C(=O)CCc3ccccc3)C[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2013.05.024 | |||
49763574 | 65465 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 477 | 6 | 2 | 3 | 4.0 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@](F)(c3ccccc3)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829636 | 65465 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 477 | 6 | 2 | 3 | 4.0 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@](F)(c3ccccc3)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
44442532 | 93538 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 506 | 9 | 4 | 4 | 3.2 | Cc1ccc(CNC[C@@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL246213 | 93538 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 506 | 9 | 4 | 4 | 3.2 | Cc1ccc(CNC[C@@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
44442594 | 93826 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 611 | 12 | 5 | 5 | 4.9 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(NCc3ccccc3)cc(C(F)(F)F)c2)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL247456 | 93826 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 611 | 12 | 5 | 5 | 4.9 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(NCc3ccccc3)cc(C(F)(F)F)c2)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
10205937 | 94016 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 478 | 10 | 4 | 4 | 2.5 | CCNC(=O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL248419 | 94016 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 478 | 10 | 4 | 4 | 2.5 | CCNC(=O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.07.028 | |||
10300282 | 154867 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 494 | 10 | 3 | 5 | 2.3 | CON(C)C(=O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL400158 | 154867 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 494 | 10 | 3 | 5 | 2.3 | CON(C)C(=O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.07.028 | |||
22310954 | 24086 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 353 | 3 | 1 | 2 | 5.3 | O=C(O)c1cc2cc(Cl)ccc2n1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2003.10.049 | |||
CHEMBL133839 | 24086 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 353 | 3 | 1 | 2 | 5.3 | O=C(O)c1cc2cc(Cl)ccc2n1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2003.10.049 | |||
71518897 | 86423 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 433 | 4 | 1 | 5 | 3.0 | COC1COCCC1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2CCc3ncc(Cl)cc3C2)C1 | 10.1016/j.bmcl.2012.10.069 | |||
CHEMBL2313782 | 86423 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 433 | 4 | 1 | 5 | 3.0 | COC1COCCC1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2CCc3ncc(Cl)cc3C2)C1 | 10.1016/j.bmcl.2012.10.069 | |||
44442571 | 154870 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 508 | 10 | 4 | 5 | 2.6 | COc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(=O)NC(C)(C)C)cc1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL400160 | 154870 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 508 | 10 | 4 | 5 | 2.6 | COc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(=O)NC(C)(C)C)cc1 | 10.1016/j.bmcl.2007.07.028 | |||
11843946 | 139632 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 490 | 7 | 1 | 2 | 6.1 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCCCC1)c1ccc(F)cc1 | 10.1021/jm060439n | |||
CHEMBL379624 | 139632 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 490 | 7 | 1 | 2 | 6.1 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCCCC1)c1ccc(F)cc1 | 10.1021/jm060439n | |||
11844079 | 141564 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 580 | 9 | 1 | 2 | 7.9 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCCN1CCC(c2ccccc2)CC1)c1ccc(F)cc1 | 10.1021/jm060439n | |||
CHEMBL384368 | 141564 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 580 | 9 | 1 | 2 | 7.9 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCCN1CCC(c2ccccc2)CC1)c1ccc(F)cc1 | 10.1021/jm060439n | |||
23655877 | 169586 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 460 | 5 | 3 | 3 | 4.7 | O=C(O)C(C1CCN(C(=O)Nc2ccccc2)CC1)N1CCC(c2c[nH]c3ccccc23)CC1 | 10.1021/jm070902b | |||
CHEMBL443058 | 169586 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 460 | 5 | 3 | 3 | 4.7 | O=C(O)C(C1CCN(C(=O)Nc2ccccc2)CC1)N1CCC(c2c[nH]c3ccccc23)CC1 | 10.1021/jm070902b | |||
44395113 | 66138 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 546 | 8 | 1 | 5 | 5.2 | CS(=O)(=O)c1ccc(CN2CCCN(CCC(O)(c3ccc(Cl)cc3)c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.08.008 | |||
CHEMBL183966 | 66138 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 546 | 8 | 1 | 5 | 5.2 | CS(=O)(=O)c1ccc(CN2CCCN(CCC(O)(c3ccc(Cl)cc3)c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmcl.2004.08.008 | |||
44395058 | 66354 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 385 | 7 | 0 | 3 | 4.8 | c1ccc(C(CCN2CCCN(Cc3ccncc3)CC2)c2ccccc2)cc1 | 10.1016/j.bmcl.2004.08.008 | |||
CHEMBL185032 | 66354 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 385 | 7 | 0 | 3 | 4.8 | c1ccc(C(CCN2CCCN(Cc3ccncc3)CC2)c2ccccc2)cc1 | 10.1016/j.bmcl.2004.08.008 | |||
18426192 | 66027 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 399 | 7 | 2 | 3 | 3.1 | O=C(CNC(=O)c1ccccc1)NCC1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2004.08.009 | |||
CHEMBL183681 | 66027 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 399 | 7 | 2 | 3 | 3.1 | O=C(CNC(=O)c1ccccc1)NCC1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2004.08.009 | |||
44395093 | 67147 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 384 | 8 | 1 | 3 | 4.1 | O=C(CCCC(=O)c1ccccc1)NC1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2004.08.009 | |||
CHEMBL187476 | 67147 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 384 | 8 | 1 | 3 | 4.1 | O=C(CCCC(=O)c1ccccc1)NC1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2004.08.009 | |||
176 | 398 | None | 47 | Human | Binding | pIC50 | = | 5.0 | 5.0 | -3 | 31 | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
2157 | 398 | None | 47 | Human | Binding | pIC50 | = | 5.0 | 5.0 | -3 | 31 | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
2157.0 | 398 | None | 47 | Human | Binding | pIC50 | = | 5.0 | 5.0 | -3 | 31 | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
2566 | 398 | None | 47 | Human | Binding | pIC50 | = | 5.0 | 5.0 | -3 | 31 | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
CHEMBL633 | 398 | None | 47 | Human | Binding | pIC50 | = | 5.0 | 5.0 | -3 | 31 | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
DB01118 | 398 | None | 47 | Human | Binding | pIC50 | = | 5.0 | 5.0 | -3 | 31 | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | |||
44425322 | 153290 | None | 0 | Mouse | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 738 | 9 | 2 | 5 | 8.6 | C[C@H]1CN(CCC(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2csc(NC(=O)C3Cc4ccccc43)n2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2006.10.059 | |||
CHEMBL397717 | 153290 | None | 0 | Mouse | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 738 | 9 | 2 | 5 | 8.6 | C[C@H]1CN(CCC(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2csc(NC(=O)C3Cc4ccccc43)n2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2006.10.059 | |||
89823655 | 126388 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 521 | 5 | 1 | 5 | 4.1 | CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2C[C@@H]3C[C@H]2CN3c2cccc(C(F)(F)F)c2C)C1 | nan | |||
CHEMBL3650368 | 126388 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 521 | 5 | 1 | 5 | 4.1 | CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2C[C@@H]3C[C@H]2CN3c2cccc(C(F)(F)F)c2C)C1 | nan | |||
44444096 | 94043 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 486 | 6 | 0 | 3 | 6.1 | COc1ccccc1C1CCN(CC2CCN(C(=O)/C=C/c3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2007.07.065 | |||
CHEMBL248617 | 94043 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 486 | 6 | 0 | 3 | 6.1 | COc1ccccc1C1CCN(CC2CCN(C(=O)/C=C/c3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2007.07.065 | |||
44570713 | 180065 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 580 | 8 | 6 | 6 | 2.5 | CNC(=O)NC1CCC(NC(=O)c2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C1 | 10.1016/j.bmcl.2008.12.062 | |||
CHEMBL474665 | 180065 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 580 | 8 | 6 | 6 | 2.5 | CNC(=O)NC1CCC(NC(=O)c2ccc(SC)cc2)C(NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C1 | 10.1016/j.bmcl.2008.12.062 | |||
46830335 | 8217 | None | 8 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 565 | 8 | 2 | 5 | 2.7 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCN2CCN(C(=O)c3ccccc3Cl)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1092238 | 8217 | None | 8 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 565 | 8 | 2 | 5 | 2.7 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCN2CCN(C(=O)c3ccccc3Cl)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
122181150 | 121904 | None | 0 | Mouse | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 608 | 7 | 1 | 3 | 7.2 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC2(CC1)OCCc1ccccc12)c1ccc(F)cc1 | 10.1016/j.bmc.2015.02.019 | |||
CHEMBL3589845 | 121904 | None | 0 | Mouse | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 608 | 7 | 1 | 3 | 7.2 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC2(CC1)OCCc1ccccc12)c1ccc(F)cc1 | 10.1016/j.bmc.2015.02.019 | |||
49863199 | 15215 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 528 | 9 | 1 | 4 | 7.1 | O=C(CCc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1)NCCCc1ccncc1 | 10.1016/j.ejmech.2010.04.024 | |||
CHEMBL1210667 | 15215 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 528 | 9 | 1 | 4 | 7.1 | O=C(CCc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1)NCCCc1ccncc1 | 10.1016/j.ejmech.2010.04.024 | |||
44439158 | 146915 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 542 | 10 | 1 | 4 | 7.5 | O=C(CCCc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1)NCCCc1ccncc1 | 10.1016/j.bmcl.2006.10.060 | |||
CHEMBL392493 | 146915 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 542 | 10 | 1 | 4 | 7.5 | O=C(CCCc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1)NCCCc1ccncc1 | 10.1016/j.bmcl.2006.10.060 | |||
46884818 | 7873 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 548 | 8 | 2 | 4 | 3.7 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCC2CCN(C(=O)c3ccccc3F)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1089881 | 7873 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 548 | 8 | 2 | 4 | 3.7 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCC2CCN(C(=O)c3ccccc3F)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
22310877 | 19550 | None | 1 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 285 | 3 | 1 | 2 | 4.0 | O=C(O)c1cc2ccccc2n1Cc1cccc(Cl)c1 | 10.1016/j.bmcl.2003.10.049 | |||
CHEMBL129958 | 19550 | None | 1 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 285 | 3 | 1 | 2 | 4.0 | O=C(O)c1cc2ccccc2n1Cc1cccc(Cl)c1 | 10.1016/j.bmcl.2003.10.049 | |||
42632811 | 93526 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 407 | 5 | 1 | 2 | 5.0 | C[N+](C)(Cc1cccc(NC(=O)c2ccc(Cl)c(Cl)c2)c1)C1CCOCC1 | 10.1016/j.bmcl.2007.01.115 | |||
CHEMBL246104 | 93526 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 407 | 5 | 1 | 2 | 5.0 | C[N+](C)(Cc1cccc(NC(=O)c2ccc(Cl)c(Cl)c2)c1)C1CCOCC1 | 10.1016/j.bmcl.2007.01.115 | |||
127027628 | 137559 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 298 | 2 | 1 | 1 | 4.7 | C[C@H]1CC=C(C(=O)O)[C@](C)(c2cc(Cl)cc(Cl)c2)C1 | 10.1016/j.bmcl.2015.11.051 | |||
CHEMBL3753826 | 137559 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 298 | 2 | 1 | 1 | 4.7 | C[C@H]1CC=C(C(=O)O)[C@](C)(c2cc(Cl)cc(Cl)c2)C1 | 10.1016/j.bmcl.2015.11.051 | |||
44453373 | 97864 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 435 | 7 | 2 | 4 | 2.8 | COc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL271935 | 97864 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 435 | 7 | 2 | 4 | 2.8 | COc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
44454793 | 155182 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 515 | 4 | 0 | 3 | 7.0 | C[C@H]1CN([C@@H]2CC[C@@]3(CCO[C@@H]3OCc3cc(F)cc(C(F)(F)F)c3)C2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.016 | |||
CHEMBL401890 | 155182 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 515 | 4 | 0 | 3 | 7.0 | C[C@H]1CN([C@@H]2CC[C@@]3(CCO[C@@H]3OCc3cc(F)cc(C(F)(F)F)c3)C2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2008.01.016 | |||
23656261 | 89107 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 485 | 6 | 2 | 3 | 5.1 | Cc1ccc(/C=C/C(=O)N2CCC(C(C(=O)O)N3CCC(c4c[nH]c5ccccc45)CC3)CC2)cc1 | 10.1021/jm070902b | |||
CHEMBL236510 | 89107 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 485 | 6 | 2 | 3 | 5.1 | Cc1ccc(/C=C/C(=O)N2CCC(C(C(=O)O)N3CCC(c4c[nH]c5ccccc45)CC3)CC2)cc1 | 10.1021/jm070902b | |||
53318855 | 58497 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 514 | 8 | 1 | 7 | 2.7 | COCC[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)CC[C@@H](N[C@H]2CCOC[C@H]2OC)C1 | 10.1016/j.bmcl.2011.01.015 | |||
CHEMBL1683083 | 58497 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 514 | 8 | 1 | 7 | 2.7 | COCC[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)CC[C@@H](N[C@H]2CCOC[C@H]2OC)C1 | 10.1016/j.bmcl.2011.01.015 | |||
44453409 | 95492 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 419 | 6 | 2 | 3 | 3.1 | Cc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL257065 | 95492 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 419 | 6 | 2 | 3 | 3.1 | Cc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
44453441 | 97742 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 498 | 6 | 3 | 4 | 3.2 | Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@@H]1CCN(Cc2ccc(Br)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL271289 | 97742 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 498 | 6 | 3 | 4 | 3.2 | Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@@H]1CCN(Cc2ccc(Br)cc2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
72946982 | 105285 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 602 | 6 | 1 | 7 | 3.8 | COC1COCCC1N[C@@H]1C[C@H]2CN(C(=O)OCc3ccccc3)C[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2013.05.024 | |||
CHEMBL3115103 | 105285 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 602 | 6 | 1 | 7 | 3.8 | COC1COCCC1N[C@@H]1C[C@H]2CN(C(=O)OCc3ccccc3)C[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2013.05.024 | |||
46842086 | 7981 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 544 | 8 | 2 | 4 | 3.9 | Cc1cccc(C(=O)N2CCC(CCN3CC[C@@H](NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)c1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1090548 | 7981 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 544 | 8 | 2 | 4 | 3.9 | Cc1cccc(C(=O)N2CCC(CCN3CC[C@@H](NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)c1 | 10.1016/j.bmcl.2010.02.072 | |||
44580424 | 188132 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 494 | 8 | 4 | 5 | 4.0 | CSc1ccc(CNC2CCCCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL497576 | 188132 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 494 | 8 | 4 | 5 | 4.0 | CSc1ccc(CNC2CCCCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
11502188 | 75227 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 398 | 4 | 1 | 3 | 3.9 | CCN1CCC[C@H](CN2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036752 | 75227 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 398 | 4 | 1 | 3 | 3.9 | CCN1CCC[C@H](CN2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
10184007 | 159154 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 475 | 7 | 3 | 3 | 4.6 | Cc1cc(C)c(CN[C@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)c(C)c1 | 10.1021/jm701488f | |||
CHEMBL409712 | 159154 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 475 | 7 | 3 | 3 | 4.6 | Cc1cc(C)c(CN[C@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)c(C)c1 | 10.1021/jm701488f | |||
22310971 | 20493 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 387 | 3 | 1 | 2 | 5.7 | O=C(O)c1cc2c(C(F)(F)F)cccc2n1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2003.10.049 | |||
CHEMBL130724 | 20493 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 387 | 3 | 1 | 2 | 5.7 | O=C(O)c1cc2c(C(F)(F)F)cccc2n1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2003.10.049 | |||
22143196 | 184093 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 509 | 7 | 5 | 6 | 2.0 | CSc1ccc(C(=O)NC2CCNCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL481790 | 184093 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 509 | 7 | 5 | 6 | 2.0 | CSc1ccc(C(=O)NC2CCNCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
56671923 | 65760 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 471 | 6 | 3 | 4 | 4.5 | O=C(CNc1n[nH]c2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](c3ccccc3)CC2)C1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834631 | 65760 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 471 | 6 | 3 | 4 | 4.5 | O=C(CNc1n[nH]c2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](c3ccccc3)CC2)C1 | 10.1016/j.bmcl.2011.08.074 | |||
54755079 | 65762 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 528 | 8 | 4 | 5 | 3.5 | NC(=O)Cc1ccc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4n[nH]c5ccc(C(F)(F)F)cc45)C3)CC2)cc1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834633 | 65762 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 528 | 8 | 4 | 5 | 3.5 | NC(=O)Cc1ccc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4n[nH]c5ccc(C(F)(F)F)cc45)C3)CC2)cc1 | 10.1016/j.bmcl.2011.08.074 | |||
54754968 | 65763 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 502 | 7 | 3 | 6 | 3.9 | COc1ccc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4n[nH]c5ccc(C(F)(F)F)cc45)C3)CC2)cn1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834634 | 65763 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 502 | 7 | 3 | 6 | 3.9 | COc1ccc([C@H]2CC[C@@H](N3CC(NC(=O)CNc4n[nH]c5ccc(C(F)(F)F)cc45)C3)CC2)cn1 | 10.1016/j.bmcl.2011.08.074 | |||
57400452 | 70533 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 539 | 9 | 3 | 5 | 3.6 | CC(C)N[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C[C@@H]1CS(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2011.12.057 | |||
CHEMBL1946832 | 70533 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 539 | 9 | 3 | 5 | 3.6 | CC(C)N[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C[C@@H]1CS(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2011.12.057 | |||
57393347 | 70363 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 623 | 10 | 4 | 6 | 3.4 | CCN[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N2CCC2)C[C@@H]1CS(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2011.12.057 | |||
CHEMBL1944777 | 70363 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 623 | 10 | 4 | 6 | 3.4 | CCN[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)N2CCC2)C[C@@H]1CS(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2011.12.057 | |||
44416138 | 138961 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 564 | 7 | 1 | 2 | 7.5 | C[C@H]1CN(CC[C@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCC2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2006.07.011 | |||
CHEMBL378195 | 138961 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 564 | 7 | 1 | 2 | 7.5 | C[C@H]1CN(CC[C@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCC2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2006.07.011 | |||
9850318 | 95298 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 542 | 6 | 1 | 4 | 6.2 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CCC(c3cncnc3)CC2)C1 | 10.1016/j.bmcl.2007.12.029 | |||
CHEMBL256154 | 95298 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 542 | 6 | 1 | 4 | 6.2 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CCC(c3cncnc3)CC2)C1 | 10.1016/j.bmcl.2007.12.029 | |||
53324942 | 58695 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 469 | 6 | 1 | 5 | 2.7 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2C[C@@H]3C[C@H]2CN3C(=O)c2ccccc2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.052 | |||
CHEMBL1684701 | 58695 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 469 | 6 | 1 | 5 | 2.7 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2C[C@@H]3C[C@H]2CN3C(=O)c2ccccc2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.052 | |||
12093170 | 872 | None | 34 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 351 | 3 | 1 | 3 | 4.2 | Clc1ccc(c(c1)F)N1[C@H](C2CCCCC2)C(=C(C1=O)O)C(=O)C | 10.1021/acs.jmedchem.0c01137 | |||
9431 | 872 | None | 34 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 351 | 3 | 1 | 3 | 4.2 | Clc1ccc(c(c1)F)N1[C@H](C2CCCCC2)C(=C(C1=O)O)C(=O)C | 10.1021/acs.jmedchem.0c01137 | |||
CHEMBL4519152 | 872 | None | 34 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 351 | 3 | 1 | 3 | 4.2 | Clc1ccc(c(c1)F)N1[C@H](C2CCCCC2)C(=C(C1=O)O)C(=O)C | 10.1021/acs.jmedchem.0c01137 | |||
162658125 | 181202 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 471 | 6 | 2 | 4 | 5.9 | O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
CHEMBL4760108 | 181202 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 471 | 6 | 2 | 4 | 5.9 | O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
53326225 | 58687 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 431 | 5 | 1 | 4 | 3.0 | CC(C)[C@]1(C(=O)N2C[C@@H]3C[C@H]2CN3C(=O)C2CCCC2)CC[C@@H](NC2CCOCC2)C1 | 10.1016/j.bmcl.2011.01.052 | |||
CHEMBL1684691 | 58687 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 431 | 5 | 1 | 4 | 3.0 | CC(C)[C@]1(C(=O)N2C[C@@H]3C[C@H]2CN3C(=O)C2CCCC2)CC[C@@H](NC2CCOCC2)C1 | 10.1016/j.bmcl.2011.01.052 | |||
44583283 | 188393 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 714 | 11 | 3 | 8 | 6.0 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)OC(C)(C)C)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL500175 | 188393 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 714 | 11 | 3 | 8 | 6.0 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)OC(C)(C)C)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
22143305 | 183718 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 506 | 9 | 3 | 5 | 3.2 | COc1ccc(CNC2CC(N(C)C)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
CHEMBL480228 | 183718 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 506 | 9 | 3 | 5 | 3.2 | COc1ccc(CNC2CC(N(C)C)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
12093170 | 872 | None | 34 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 351 | 3 | 1 | 3 | 4.2 | Clc1ccc(c(c1)F)N1[C@H](C2CCCCC2)C(=C(C1=O)O)C(=O)C | 10.1021/acs.jmedchem.0c01137 | |||
9431 | 872 | None | 34 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 351 | 3 | 1 | 3 | 4.2 | Clc1ccc(c(c1)F)N1[C@H](C2CCCCC2)C(=C(C1=O)O)C(=O)C | 10.1021/acs.jmedchem.0c01137 | |||
CHEMBL4519152 | 872 | None | 34 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 351 | 3 | 1 | 3 | 4.2 | Clc1ccc(c(c1)F)N1[C@H](C2CCCCC2)C(=C(C1=O)O)C(=O)C | 10.1021/acs.jmedchem.0c01137 | |||
162658125 | 181202 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 471 | 6 | 2 | 4 | 5.9 | O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
CHEMBL4760108 | 181202 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 471 | 6 | 2 | 4 | 5.9 | O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
53324943 | 58701 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 491 | 6 | 1 | 4 | 3.3 | CC(CC(=O)N1C[C@@H]2C[C@H]1CN2C(=O)[C@@]1(C(C)C)CC[C@@H](NC2CCOCC2F)C1)C(F)(F)F | 10.1016/j.bmcl.2011.01.052 | |||
CHEMBL1684707 | 58701 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 491 | 6 | 1 | 4 | 3.3 | CC(CC(=O)N1C[C@@H]2C[C@H]1CN2C(=O)[C@@]1(C(C)C)CC[C@@H](NC2CCOCC2F)C1)C(F)(F)F | 10.1016/j.bmcl.2011.01.052 | |||
57343818 | 130697 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 524 | 7 | 3 | 3 | 5.1 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2ccc3c(c2)CCC3)CC1 | nan | |||
CHEMBL3681876 | 130697 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 524 | 7 | 3 | 3 | 5.1 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2ccc3c(c2)CCC3)CC1 | nan | |||
86767127 | 129478 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 483 | 4 | 1 | 7 | 1.8 | COC1COCCC1NC1CC2OC(=O)CC2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | nan | |||
CHEMBL3671260 | 129478 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 483 | 4 | 1 | 7 | 1.8 | COC1COCCC1NC1CC2OC(=O)CC2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | nan | |||
56671924 | 65768 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 491 | 6 | 2 | 5 | 4.9 | Cn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](C4CCCCC4)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834639 | 65768 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 491 | 6 | 2 | 5 | 4.9 | Cn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](C4CCCCC4)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
44441358 | 149934 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 427 | 5 | 1 | 3 | 4.5 | C[N+](C)(Cc1ccc(NC(=O)C2=Cc3ccc(Cl)cc3OC2)cc1)C1CCOCC1 | 10.1016/j.bmcl.2007.01.115 | |||
CHEMBL394897 | 149934 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 427 | 5 | 1 | 3 | 4.5 | C[N+](C)(Cc1ccc(NC(=O)C2=Cc3ccc(Cl)cc3OC2)cc1)C1CCOCC1 | 10.1016/j.bmcl.2007.01.115 | |||
52942863 | 19256 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 475 | 6 | 3 | 4 | 2.9 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@H]1CN([C@H]2CC[C@@H](c3ccccc3)C2)C[C@@H]1O | 10.1016/j.bmcl.2010.10.020 | |||
CHEMBL1290186 | 19256 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 475 | 6 | 3 | 4 | 2.9 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@H]1CN([C@H]2CC[C@@H](c3ccccc3)C2)C[C@@H]1O | 10.1016/j.bmcl.2010.10.020 | |||
44442581 | 93601 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 507 | 9 | 5 | 5 | 2.5 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(=O)NC(C)(C)C)cc1N | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL246410 | 93601 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 507 | 9 | 5 | 5 | 2.5 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(=O)NC(C)(C)C)cc1N | 10.1016/j.bmcl.2007.07.028 | |||
44442555 | 93779 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 520 | 11 | 4 | 4 | 3.6 | CCC(C)(C)NC(=O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL247203 | 93779 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 520 | 11 | 4 | 4 | 3.6 | CCC(C)(C)NC(=O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.07.028 | |||
44442554 | 94020 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 506 | 11 | 4 | 4 | 3.1 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(=O)NCC(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL248423 | 94020 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 506 | 11 | 4 | 4 | 3.1 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(=O)NCC(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
11844595 | 136453 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 604 | 7 | 1 | 2 | 8.0 | C[C@@H]1CN(CC[C@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccc(F)cc2)CC[C@]12C=Cc1ccccc12 | 10.1021/jm060439n | |||
CHEMBL373491 | 136453 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 604 | 7 | 1 | 2 | 8.0 | C[C@@H]1CN(CC[C@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccc(F)cc2)CC[C@]12C=Cc1ccccc12 | 10.1021/jm060439n | |||
44353395 | 20100 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 333 | 3 | 1 | 2 | 5.0 | Cc1ccc(Cn2c(C(=O)O)cc3cc(Cl)ccc32)cc1Cl | 10.1016/j.bmcl.2003.10.049 | |||
CHEMBL130403 | 20100 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 333 | 3 | 1 | 2 | 5.0 | Cc1ccc(Cn2c(C(=O)O)cc3cc(Cl)ccc32)cc1Cl | 10.1016/j.bmcl.2003.10.049 | |||
11635092 | 89859 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 528 | 5 | 3 | 3 | 5.8 | O=C(O)C(C1CCN(C(=O)Nc2ccc(C(F)(F)F)cc2)CC1)N1CCC(c2c[nH]c3ccccc23)CC1 | 10.1021/jm070902b | |||
CHEMBL237753 | 89859 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 528 | 5 | 3 | 3 | 5.8 | O=C(O)C(C1CCN(C(=O)Nc2ccc(C(F)(F)F)cc2)CC1)N1CCC(c2c[nH]c3ccccc23)CC1 | 10.1021/jm070902b | |||
69212799 | 78005 | None | 2 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 439 | 6 | 2 | 3 | 3.5 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2004.08.009 | |||
CHEMBL2096789 | 78005 | None | 2 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 439 | 6 | 2 | 3 | 3.5 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@H]1CCN(Cc2ccc(Cl)cc2)C1 | 10.1016/j.bmcl.2004.08.009 | |||
56677296 | 65441 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 503 | 6 | 2 | 5 | 3.7 | O=C(CNC(=O)c1ccc(C(F)(F)F)cc1)NC1CN([C@H]2CC[C@H](c3ccc4c(c3)OCO4)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829611 | 65441 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 503 | 6 | 2 | 5 | 3.7 | O=C(CNC(=O)c1ccc(C(F)(F)F)cc1)NC1CN([C@H]2CC[C@H](c3ccc4c(c3)OCO4)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
25256791 | 187797 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 494 | 6 | 2 | 3 | 5.6 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N[C@H]2CCOC[C@H]2C)C1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL495202 | 187797 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 494 | 6 | 2 | 3 | 5.6 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N[C@H]2CCOC[C@H]2C)C1 | 10.1016/j.bmcl.2010.02.072 | |||
10143025 | 93590 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 526 | 10 | 4 | 4 | 4.0 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(=O)Nc2ccccc2)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL246397 | 93590 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 526 | 10 | 4 | 4 | 4.0 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(=O)Nc2ccccc2)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
44444008 | 155135 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 478 | 9 | 1 | 2 | 6.8 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCCCN1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.07.065 | |||
CHEMBL401637 | 155135 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 478 | 9 | 1 | 2 | 6.8 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCCCN1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.07.065 | |||
44395194 | 64788 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 496 | 8 | 1 | 5 | 4.1 | CS(=O)(=O)c1ccc(CN2CCCN(CCC(O)(c3ccccc3)c3cccc(F)c3)CC2)cc1 | 10.1016/j.bmcl.2004.08.008 | |||
CHEMBL181918 | 64788 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 496 | 8 | 1 | 5 | 4.1 | CS(=O)(=O)c1ccc(CN2CCCN(CCC(O)(c3ccccc3)c3cccc(F)c3)CC2)cc1 | 10.1016/j.bmcl.2004.08.008 | |||
25008679 | 94231 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 454 | 7 | 1 | 3 | 5.2 | COc1ccc(C2CCN(C[C@H]3CC[C@@H](NC(=O)/C=C/c4cc(F)cc(F)c4)C3)CC2)cc1 | 10.1016/j.bmcl.2007.07.065 | |||
CHEMBL249607 | 94231 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 454 | 7 | 1 | 3 | 5.2 | COc1ccc(C2CCN(C[C@H]3CC[C@@H](NC(=O)/C=C/c4cc(F)cc(F)c4)C3)CC2)cc1 | 10.1016/j.bmcl.2007.07.065 | |||
24801178 | 156934 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 481 | 6 | 3 | 3 | 3.9 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@H]1CCCC[C@@H]1NC(=O)c1ccc(Cl)cc1 | 10.1021/jm701488f | |||
CHEMBL407145 | 156934 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 481 | 6 | 3 | 3 | 3.9 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@H]1CCCC[C@@H]1NC(=O)c1ccc(Cl)cc1 | 10.1021/jm701488f | |||
44453329 | 155441 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 431 | 7 | 2 | 3 | 3.5 | C=Cc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL403281 | 155441 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 431 | 7 | 2 | 3 | 3.5 | C=Cc1ccc(CN2CC[C@@H](NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)cc1 | 10.1016/j.bmcl.2008.02.015 | |||
22310903 | 22622 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 349 | 4 | 1 | 3 | 4.7 | COc1cccc2cc(C(=O)O)n(Cc3ccc(Cl)c(Cl)c3)c12 | 10.1016/j.bmcl.2003.10.049 | |||
CHEMBL132662 | 22622 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 349 | 4 | 1 | 3 | 4.7 | COc1cccc2cc(C(=O)O)n(Cc3ccc(Cl)c(Cl)c3)c12 | 10.1016/j.bmcl.2003.10.049 | |||
76325121 | 105297 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 510 | 5 | 1 | 6 | 2.9 | COC1COCCC1N[C@@H]1C[C@H]2CN(C(C)C)C[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2013.05.024 | |||
CHEMBL3115115 | 105297 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 510 | 5 | 1 | 6 | 2.9 | COC1COCCC1N[C@@H]1C[C@H]2CN(C(C)C)C[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2013.05.024 | |||
57344309 | 130721 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 485 | 7 | 3 | 4 | 4.0 | NC(=O)C(N[C@H]1CC[C@H](c2c[nH]c3cccnc32)CC1)C1CCN(C(=O)/C=C/c2ccccc2)CC1 | nan | |||
CHEMBL3681899 | 130721 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 485 | 7 | 3 | 4 | 4.0 | NC(=O)C(N[C@H]1CC[C@H](c2c[nH]c3cccnc32)CC1)C1CCN(C(=O)/C=C/c2ccccc2)CC1 | nan | |||
49863201 | 15217 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 536 | 12 | 1 | 4 | 7.2 | CCN(CC)CCCCNC(=O)CCc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.ejmech.2010.04.024 | |||
CHEMBL1210669 | 15217 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 536 | 12 | 1 | 4 | 7.2 | CCN(CC)CCCCNC(=O)CCc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.ejmech.2010.04.024 | |||
11663995 | 146916 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 550 | 13 | 1 | 4 | 7.6 | CCN(CC)CCCCNC(=O)CCCc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
CHEMBL392494 | 146916 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 550 | 13 | 1 | 4 | 7.6 | CCN(CC)CCCCNC(=O)CCCc1cc(-c2cc(Cl)cc(Cl)c2)nn1-c1ccc2ccccc2c1 | 10.1016/j.bmcl.2006.10.060 | |||
11567495 | 75225 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 398 | 4 | 1 | 3 | 3.9 | CCN1CCCC(CN2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036750 | 75225 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 398 | 4 | 1 | 3 | 3.9 | CCN1CCCC(CN2CCN(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)C1 | 10.1016/j.bmcl.2012.04.118 | |||
10052388 | 187658 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 520 | 7 | 2 | 3 | 5.9 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](NC2CCOCC2C2CC2)C1 | 10.1016/j.bmcl.2008.12.050 | |||
CHEMBL494541 | 187658 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 520 | 7 | 2 | 3 | 5.9 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](NC2CCOCC2C2CC2)C1 | 10.1016/j.bmcl.2008.12.050 | |||
22143308 | 187870 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 509 | 9 | 5 | 6 | 2.8 | CCSc1ccc(CNC2CCNCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
CHEMBL495717 | 187870 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 509 | 9 | 5 | 6 | 2.8 | CCSc1ccc(CNC2CCNCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 | 10.1016/j.bmcl.2008.07.123 | |||
44573609 | 187659 | None | 1 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 496 | 6 | 3 | 4 | 4.3 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](NC2CCOCC2O)C1 | 10.1007/s00044-010-9501-4 | |||
CHEMBL494542 | 187659 | None | 1 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 496 | 6 | 3 | 4 | 4.3 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](NC2CCOCC2O)C1 | 10.1007/s00044-010-9501-4 | |||
10256127 | 73839 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 520 | 10 | 4 | 5 | 3.6 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)N1CC[C@H](NC(=O)c2cc(N)cc(C(F)(F)F)c2)C1=O | 10.1016/j.bmcl.2012.03.007 | |||
CHEMBL2018539 | 73839 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 520 | 10 | 4 | 5 | 3.6 | CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)N1CC[C@H](NC(=O)c2cc(N)cc(C(F)(F)F)c2)C1=O | 10.1016/j.bmcl.2012.03.007 | |||
44353356 | 117664 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 395 | 4 | 1 | 2 | 6.4 | O=C(O)c1cc2ccc(-c3ccccc3)cc2n1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2003.10.049 | |||
CHEMBL340072 | 117664 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 395 | 4 | 1 | 2 | 6.4 | O=C(O)c1cc2ccc(-c3ccccc3)cc2n1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2003.10.049 | |||
11227383 | 77676 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 620 | 11 | 2 | 5 | 6.2 | CC(C)CCc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2NC(=O)Cc2nc3cccc(C(F)(F)F)c3[nH]2)cc1 | 10.1016/j.bmcl.2012.08.002 | |||
CHEMBL2088387 | 77676 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 620 | 11 | 2 | 5 | 6.2 | CC(C)CCc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2NC(=O)Cc2nc3cccc(C(F)(F)F)c3[nH]2)cc1 | 10.1016/j.bmcl.2012.08.002 | |||
71226374 | 86440 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 437 | 3 | 1 | 4 | 3.7 | O=C(N1CCc2ncc(C(F)(F)F)cc2C1)[C@@]12CCC[C@@H]1C[C@@H](NC1CCOCC1)C2 | 10.1016/j.bmcl.2012.10.069 | |||
CHEMBL2314061 | 86440 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 437 | 3 | 1 | 4 | 3.7 | O=C(N1CCc2ncc(C(F)(F)F)cc2C1)[C@@]12CCC[C@@H]1C[C@@H](NC1CCOCC1)C2 | 10.1016/j.bmcl.2012.10.069 | |||
44416066 | 79818 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 643 | 8 | 2 | 4 | 5.6 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC2(C=Cc3ccccc32)CC1)NS(=O)(=O)C(F)(F)F | 10.1016/j.bmcl.2006.07.011 | |||
CHEMBL211923 | 79818 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 643 | 8 | 2 | 4 | 5.6 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC2(C=Cc3ccccc32)CC1)NS(=O)(=O)C(F)(F)F | 10.1016/j.bmcl.2006.07.011 | |||
22310929 | 168397 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 337 | 3 | 1 | 2 | 4.8 | O=C(O)c1cc2cccc(F)c2n1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2003.10.049 | |||
CHEMBL434059 | 168397 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 337 | 3 | 1 | 2 | 4.8 | O=C(O)c1cc2cccc(F)c2n1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2003.10.049 | |||
71517402 | 86416 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 535 | 4 | 1 | 5 | 4.1 | COC1COCCC1N[C@@H]1C[C@H]2C[C@H](C(F)(F)F)C[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2012.10.069 | |||
CHEMBL2313774 | 86416 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 535 | 4 | 1 | 5 | 4.1 | COC1COCCC1N[C@@H]1C[C@H]2C[C@H](C(F)(F)F)C[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2012.10.069 | |||
72946204 | 105308 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 524 | 5 | 1 | 7 | 1.9 | COC1COCCC1N[C@@H]1C[C@H]2CN(C3COC3)C[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2013.05.024 | |||
CHEMBL3115267 | 105308 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 524 | 5 | 1 | 7 | 1.9 | COC1COCCC1N[C@@H]1C[C@H]2CN(C3COC3)C[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2013.05.024 | |||
44415904 | 80461 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 514 | 9 | 1 | 2 | 7.0 | CCC[C@H](CCN1CCC(c2ccccc2)CC1)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.07.011 | |||
CHEMBL214641 | 80461 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 514 | 9 | 1 | 2 | 7.0 | CCC[C@H](CCN1CCC(c2ccccc2)CC1)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.07.011 | |||
11329328 | 74559 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 490 | 6 | 3 | 5 | 2.9 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3cccnc3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
CHEMBL2029411 | 74559 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 490 | 6 | 3 | 5 | 2.9 | O=C(NCC(=O)N1CC[C@H](N[C@H]2CC[C@@](O)(c3cccnc3)CC2)C1)c1cccc(C(F)(F)F)c1 | 10.1021/ml200199c | |||
44425630 | 86061 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 550 | 4 | 1 | 2 | 7.2 | C[C@H]1CN([C@@H]2CC[C@](C)(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2007.04.053 | |||
CHEMBL230617 | 86061 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 550 | 4 | 1 | 2 | 7.2 | C[C@H]1CN([C@@H]2CC[C@](C)(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2007.04.053 | |||
44444035 | 94340 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 460 | 9 | 2 | 3 | 5.9 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCCCN1CCC(c2ccc(O)cc2)CC1 | 10.1016/j.bmcl.2007.07.065 | |||
CHEMBL250408 | 94340 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 460 | 9 | 2 | 3 | 5.9 | O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCCCN1CCC(c2ccc(O)cc2)CC1 | 10.1016/j.bmcl.2007.07.065 | |||
44353617 | 19672 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 334 | 3 | 2 | 3 | 4.3 | Nc1ccc2cc(C(=O)O)n(Cc3ccc(Cl)c(Cl)c3)c2c1 | 10.1016/j.bmcl.2003.10.049 | |||
CHEMBL130065 | 19672 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 334 | 3 | 2 | 3 | 4.3 | Nc1ccc2cc(C(=O)O)n(Cc3ccc(Cl)c(Cl)c3)c2c1 | 10.1016/j.bmcl.2003.10.049 | |||
57656942 | 75065 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 376 | 4 | 1 | 3 | 3.4 | O=C(Nc1ccc(Cl)cc1)N1CCN(C[C@@H]2CCCN(C3CC3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2035000 | 75065 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 376 | 4 | 1 | 3 | 3.4 | O=C(Nc1ccc(Cl)cc1)N1CCN(C[C@@H]2CCCN(C3CC3)C2)CC1 | 10.1016/j.bmcl.2012.04.118 | |||
22310953 | 23973 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 387 | 3 | 1 | 2 | 5.7 | O=C(O)c1cc2cccc(C(F)(F)F)c2n1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2003.10.049 | |||
CHEMBL133748 | 23973 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 387 | 3 | 1 | 2 | 5.7 | O=C(O)c1cc2cccc(C(F)(F)F)c2n1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2003.10.049 | |||
44353170 | 21422 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 318 | 3 | 1 | 2 | 4.1 | NC(=O)c1cc2ccccc2n1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2003.10.049 | |||
CHEMBL131493 | 21422 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 318 | 3 | 1 | 2 | 4.1 | NC(=O)c1cc2ccccc2n1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2003.10.049 | |||
44425650 | 86164 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 570 | 9 | 1 | 2 | 8.3 | CCCCCCC1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CCC(N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2007.04.053 | |||
CHEMBL231143 | 86164 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 570 | 9 | 1 | 2 | 8.3 | CCCCCCC1(C(=O)NCc2cc(F)cc(C(F)(F)F)c2)CCC(N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2007.04.053 | |||
89853102 | 111167 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 552 | 5 | 1 | 8 | 3.5 | COC1COCCC1N[C@@H]1C[C@H]2OC(c3nccs3)C[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2014.03.036 | |||
CHEMBL3263260 | 111167 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 552 | 5 | 1 | 8 | 3.5 | COC1COCCC1N[C@@H]1C[C@H]2OC(c3nccs3)C[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2014.03.036 | |||
44415903 | 81181 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 512 | 8 | 1 | 2 | 6.6 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(c2ccccc2)CC1)C1CC1 | 10.1016/j.bmcl.2006.07.011 | |||
CHEMBL215759 | 81181 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 512 | 8 | 1 | 2 | 6.6 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(c2ccccc2)CC1)C1CC1 | 10.1016/j.bmcl.2006.07.011 | |||
89823502 | 126382 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 525 | 5 | 1 | 5 | 4.0 | CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2C[C@@H]3C[C@H]2CN3c2cccc(C(F)(F)F)c2F)C1 | nan | |||
CHEMBL3650362 | 126382 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 525 | 5 | 1 | 5 | 4.0 | CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2C[C@@H]3C[C@H]2CN3c2cccc(C(F)(F)F)c2F)C1 | nan | |||
56643545 | 130691 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 520 | 7 | 3 | 3 | 4.9 | NC(=O)C(N[C@H]1CC[C@H](c2c[nH]c3ccccc32)CC1)C1CCN(C(=O)/C=C/c2cc(F)cc(F)c2)CC1 | nan | |||
CHEMBL3681870 | 130691 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 520 | 7 | 3 | 3 | 4.9 | NC(=O)C(N[C@H]1CC[C@H](c2c[nH]c3ccccc32)CC1)C1CCN(C(=O)/C=C/c2cc(F)cc(F)c2)CC1 | nan | |||
11192346 | 2024 | None | 45 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(N1CC[C@@H](C1)NC1CCC(CC1)(O)c1ccc(cn1)c1ncccn1)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200199c | |||
9032 | 2024 | None | 45 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(N1CC[C@@H](C1)NC1CCC(CC1)(O)c1ccc(cn1)c1ncccn1)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200199c | |||
CHEMBL2029422 | 2024 | None | 45 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 568 | 7 | 3 | 7 | 3.3 | O=C(N1CC[C@@H](C1)NC1CCC(CC1)(O)c1ccc(cn1)c1ncccn1)CNC(=O)c1cccc(c1)C(F)(F)F | 10.1021/ml200199c | |||
46947816 | 65454 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 476 | 6 | 3 | 5 | 3.1 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3ccc(O)cn3)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829624 | 65454 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 476 | 6 | 3 | 5 | 3.1 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3ccc(O)cn3)CC2)C1 | 10.1016/j.bmcl.2011.06.080 | |||
56664979 | 65764 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 529 | 6 | 2 | 7 | 4.3 | Cn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](c4ccc5c(c4)OCO5)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834635 | 65764 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 529 | 6 | 2 | 7 | 4.3 | Cn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](c4ccc5c(c4)OCO5)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
56671925 | 65770 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 481 | 7 | 2 | 7 | 2.9 | CCOC(=O)[C@H]1CC[C@@H](N2CC(NC(=O)CNc3nn(C)c4ccc(C(F)(F)F)cc34)C2)CC1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834640 | 65770 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 481 | 7 | 2 | 7 | 2.9 | CCOC(=O)[C@H]1CC[C@@H](N2CC(NC(=O)CNc3nn(C)c4ccc(C(F)(F)F)cc34)C2)CC1 | 10.1016/j.bmcl.2011.08.074 | |||
56678508 | 65822 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 492 | 6 | 2 | 7 | 4.0 | Cn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](c4nccs4)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834794 | 65822 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 492 | 6 | 2 | 7 | 4.0 | Cn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](c4nccs4)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
44415899 | 80105 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 550 | 7 | 1 | 2 | 7.1 | C[C@H]1CN(CC[C@@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CC2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2006.07.011 | |||
CHEMBL213058 | 80105 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 550 | 7 | 1 | 2 | 7.1 | C[C@H]1CN(CC[C@@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CC2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2006.07.011 | |||
44425641 | 86100 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 596 | 6 | 1 | 3 | 7.5 | CSC[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2007.04.053 | |||
CHEMBL230832 | 86100 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 596 | 6 | 1 | 3 | 7.5 | CSC[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2007.04.053 | |||
44413258 | 77787 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 446 | 8 | 1 | 2 | 5.5 | CN(C)CCC[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2006.04.045 | |||
CHEMBL209063 | 77787 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 446 | 8 | 1 | 2 | 5.5 | CN(C)CCC[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2006.04.045 | |||
44425315 | 86282 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 536 | 8 | 2 | 5 | 5.4 | CC(=O)Nc1nc(C(CCN2CCCCC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
CHEMBL231252 | 86282 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 536 | 8 | 2 | 5 | 5.4 | CC(=O)Nc1nc(C(CCN2CCCCC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
44425319 | 86369 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 727 | 10 | 2 | 6 | 7.9 | C[C@H]1CN(CCC(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2csc(NC(=O)Cc3ccccn3)n2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2006.10.059 | |||
CHEMBL231340 | 86369 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 727 | 10 | 2 | 6 | 7.9 | C[C@H]1CN(CCC(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2csc(NC(=O)Cc3ccccn3)n2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2006.10.059 | |||
53318315 | 58690 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 473 | 6 | 1 | 4 | 3.4 | CC(CC(=O)N1C[C@@H]2C[C@H]1CN2C(=O)[C@@]1(C(C)C)CC[C@@H](NC2CCOCC2)C1)C(F)(F)F | 10.1016/j.bmcl.2011.01.052 | |||
CHEMBL1684695 | 58690 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 473 | 6 | 1 | 4 | 3.4 | CC(CC(=O)N1C[C@@H]2C[C@H]1CN2C(=O)[C@@]1(C(C)C)CC[C@@H](NC2CCOCC2)C1)C(F)(F)F | 10.1016/j.bmcl.2011.01.052 | |||
54584109 | 62567 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 509 | 5 | 1 | 6 | 3.7 | CC(C)[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)cnn3)CC2)CC[C@@H](NC2C3CCCC2COC3)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782379 | 62567 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 509 | 5 | 1 | 6 | 3.7 | CC(C)[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)cnn3)CC2)CC[C@@H](NC2C3CCCC2COC3)C1 | 10.1016/j.bmcl.2011.01.034 | |||
10187492 | 147878 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 549 | 11 | 5 | 5 | 3.7 | CCNc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@@H](CNCc1ccc(C)cc1C)C(=O)NC(C)(C)C | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL393267 | 147878 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 549 | 11 | 5 | 5 | 3.7 | CCNc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@@H](CNCc1ccc(C)cc1C)C(=O)NC(C)(C)C | 10.1016/j.bmcl.2007.07.028 | |||
69285531 | 121291 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 441 | 8 | 2 | 3 | 4.2 | CCC[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1021/ml500505q | |||
CHEMBL3577935 | 121291 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 441 | 8 | 2 | 3 | 4.2 | CCC[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1021/ml500505q | |||
10152864 | 187980 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 543 | 8 | 3 | 6 | 3.2 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N)CC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
CHEMBL496432 | 187980 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 543 | 8 | 3 | 6 | 3.2 | CSc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N)CC[C@@H]2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2009.05.041 | |||
44425288 | 86049 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 570 | 8 | 2 | 5 | 6.4 | Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
CHEMBL230507 | 86049 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 570 | 8 | 2 | 5 | 6.4 | Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
44425304 | 143454 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 670 | 9 | 2 | 6 | 8.2 | CC(C)(C)OC(=O)Nc1nc([C@@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
CHEMBL389773 | 143454 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 670 | 9 | 2 | 6 | 8.2 | CC(C)(C)OC(=O)Nc1nc([C@@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
53326721 | 58510 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 554 | 6 | 2 | 7 | 2.6 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(O)C(F)(F)F)C1 | 10.1016/j.bmcl.2011.01.015 | |||
CHEMBL1683189 | 58510 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 554 | 6 | 2 | 7 | 2.6 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(O)C(F)(F)F)C1 | 10.1016/j.bmcl.2011.01.015 | |||
53326901 | 58699 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 449 | 5 | 1 | 4 | 2.9 | CC(C)[C@]1(C(=O)N2C[C@@H]3C[C@H]2CN3C(=O)C2CCCC2)CC[C@@H](NC2CCOCC2F)C1 | 10.1016/j.bmcl.2011.01.052 | |||
CHEMBL1684705 | 58699 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 449 | 5 | 1 | 4 | 2.9 | CC(C)[C@]1(C(=O)N2C[C@@H]3C[C@H]2CN3C(=O)C2CCCC2)CC[C@@H](NC2CCOCC2F)C1 | 10.1016/j.bmcl.2011.01.052 | |||
57343820 | 68976 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 518 | 7 | 3 | 3 | 5.2 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2ccc(Cl)cc2)CC1 | nan | |||
CHEMBL1922816 | 68976 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 518 | 7 | 3 | 3 | 5.2 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2ccc(Cl)cc2)CC1 | nan | |||
57343819 | 130694 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 541 | 6 | 4 | 3 | 5.6 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)Nc2ccc(C(F)(F)F)cc2)CC1 | nan | |||
CHEMBL3681873 | 130694 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 541 | 6 | 4 | 3 | 5.6 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)Nc2ccc(C(F)(F)F)cc2)CC1 | nan | |||
57344311 | 130723 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 521 | 7 | 3 | 4 | 4.3 | NC(=O)C(NC1CCC(c2c[nH]c3cccnc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)cc(F)c2)CC1 | nan | |||
CHEMBL3681900 | 130723 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 521 | 7 | 3 | 4 | 4.3 | NC(=O)C(NC1CCC(c2c[nH]c3cccnc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)cc(F)c2)CC1 | nan | |||
71719764 | 86419 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 510 | 5 | 2 | 6 | 2.0 | COC1COCCC1N[C@@H]1C[C@H]2C[C@@H](C(N)=O)C[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2012.10.069 | |||
CHEMBL2313777 | 86419 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 510 | 5 | 2 | 6 | 2.0 | COC1COCCC1N[C@@H]1C[C@H]2C[C@@H](C(N)=O)C[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2012.10.069 | |||
57396832 | 70359 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 525 | 8 | 2 | 5 | 3.1 | CN(C)[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C[C@@H]1CS(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2011.12.057 | |||
CHEMBL1944773 | 70359 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 525 | 8 | 2 | 5 | 3.1 | CN(C)[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C[C@@H]1CS(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2011.12.057 | |||
53320968 | 58685 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 403 | 5 | 1 | 4 | 2.2 | CC(C)[C@]1(C(=O)N2C[C@@H]3C[C@H]2CN3C(=O)C2CC2)CC[C@@H](NC2CCOCC2)C1 | 10.1016/j.bmcl.2011.01.052 | |||
CHEMBL1684689 | 58685 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 403 | 5 | 1 | 4 | 2.2 | CC(C)[C@]1(C(=O)N2C[C@@H]3C[C@H]2CN3C(=O)C2CC2)CC[C@@H](NC2CCOCC2)C1 | 10.1016/j.bmcl.2011.01.052 | |||
44442553 | 93541 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 492 | 10 | 4 | 4 | 2.9 | CCNC(=O)[C@@H](NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1)[C@@H](C)NCc1ccc(C)cc1C | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL246221 | 93541 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 492 | 10 | 4 | 4 | 2.9 | CCNC(=O)[C@@H](NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1)[C@@H](C)NCc1ccc(C)cc1C | 10.1016/j.bmcl.2007.07.028 | |||
44442595 | 166503 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 577 | 12 | 5 | 5 | 4.3 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(NCC(C)C)cc(C(F)(F)F)c2)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL427705 | 166503 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 577 | 12 | 5 | 5 | 4.3 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(NCC(C)C)cc(C(F)(F)F)c2)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
44444113 | 94232 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 472 | 7 | 1 | 3 | 5.3 | COc1ccc(C2CCN(CC3CCC(NC(=O)/C=C/c4cc(F)c(F)c(F)c4)C3)CC2)cc1 | 10.1016/j.bmcl.2007.07.065 | |||
CHEMBL249608 | 94232 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 472 | 7 | 1 | 3 | 5.3 | COc1ccc(C2CCN(CC3CCC(NC(=O)/C=C/c4cc(F)c(F)c(F)c4)C3)CC2)cc1 | 10.1016/j.bmcl.2007.07.065 | |||
11606411 | 85342 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 550 | 4 | 1 | 2 | 7.2 | C[C@H]1CN([C@@H]2CC[C@](C)(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC[C@@]12C=Cc1ccccc12 | 10.1021/jm070166b | |||
CHEMBL226066 | 85342 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 550 | 4 | 1 | 2 | 7.2 | C[C@H]1CN([C@@H]2CC[C@](C)(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC[C@@]12C=Cc1ccccc12 | 10.1021/jm070166b | |||
72946384 | 105311 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 546 | 5 | 1 | 8 | 2.5 | COC1COCCC1N[C@@H]1C[C@H]2CN(c3ncccn3)C[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2013.05.024 | |||
CHEMBL3115270 | 105311 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 546 | 5 | 1 | 8 | 2.5 | COC1COCCC1N[C@@H]1C[C@H]2CN(c3ncccn3)C[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2013.05.024 | |||
44442583 | 93603 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 536 | 10 | 4 | 5 | 3.3 | COc1cc(C)c(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(=O)NC(C)(C)C)cc1C | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL246412 | 93603 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 536 | 10 | 4 | 5 | 3.3 | COc1cc(C)c(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(=O)NC(C)(C)C)cc1C | 10.1016/j.bmcl.2007.07.028 | |||
9890559 | 66149 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 462 | 8 | 0 | 4 | 4.8 | CS(=O)(=O)c1ccc(CN2CCCN(CCC(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1016/j.bmcl.2004.08.008 | |||
CHEMBL184053 | 66149 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 462 | 8 | 0 | 4 | 4.8 | CS(=O)(=O)c1ccc(CN2CCCN(CCC(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1016/j.bmcl.2004.08.008 | |||
11273475 | 77675 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 606 | 10 | 2 | 5 | 5.8 | CC(C)Cc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2NC(=O)Cc2nc3cccc(C(F)(F)F)c3[nH]2)cc1 | 10.1016/j.bmcl.2012.08.002 | |||
CHEMBL2088386 | 77675 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 606 | 10 | 2 | 5 | 5.8 | CC(C)Cc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2NC(=O)Cc2nc3cccc(C(F)(F)F)c3[nH]2)cc1 | 10.1016/j.bmcl.2012.08.002 | |||
46884898 | 7719 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 564 | 8 | 2 | 4 | 4.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCC2CCN(C(=O)c3ccccc3Cl)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1088874 | 7719 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 564 | 8 | 2 | 4 | 4.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCC2CCN(C(=O)c3ccccc3Cl)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
22310946 | 20762 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 364 | 4 | 1 | 4 | 4.6 | O=C(O)c1cc2c([N+](=O)[O-])cccc2n1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2003.10.049 | |||
CHEMBL130937 | 20762 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 364 | 4 | 1 | 4 | 4.6 | O=C(O)c1cc2c([N+](=O)[O-])cccc2n1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2003.10.049 | |||
57344310 | 68958 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 539 | 7 | 3 | 4 | 4.4 | NC(=O)C(NC1CCC(c2c[nH]c3ncccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | nan | |||
CHEMBL1922794 | 68958 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 539 | 7 | 3 | 4 | 4.4 | NC(=O)C(NC1CCC(c2c[nH]c3ncccc23)CC1)C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1 | nan | |||
15518124 | 138513 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 402 | 5 | 1 | 3 | 5.5 | CN(CCN1CCCCC1)c1ccc(-c2nc3cc(Cl)c(Cl)cc3[nH]2)cc1 | 10.1016/j.bmcl.2006.04.045 | |||
CHEMBL377432 | 138513 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 402 | 5 | 1 | 3 | 5.5 | CN(CCN1CCCCC1)c1ccc(-c2nc3cc(Cl)c(Cl)cc3[nH]2)cc1 | 10.1016/j.bmcl.2006.04.045 | |||
44425649 | 86163 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 554 | 6 | 1 | 2 | 7.5 | C[C@H]1CN(C2CCC(CC3CCC3)(C(=O)NCc3cc(F)cc(C(F)(F)F)c3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2007.04.053 | |||
CHEMBL231142 | 86163 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 554 | 6 | 1 | 2 | 7.5 | C[C@H]1CN(C2CCC(CC3CCC3)(C(=O)NCc3cc(F)cc(C(F)(F)F)c3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2007.04.053 | |||
54586021 | 62563 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 494 | 4 | 0 | 5 | 4.1 | CC(C)[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)CC[C@@H](N2CCC3COCCC32)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782375 | 62563 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 494 | 4 | 0 | 5 | 4.1 | CC(C)[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)CC[C@@H](N2CCC3COCCC32)C1 | 10.1016/j.bmcl.2011.01.034 | |||
44570779 | 183674 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 550 | 9 | 4 | 5 | 4.0 | CSc1ccc(C(=O)NC2CCC(NC(C)C)CC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
CHEMBL480036 | 183674 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 550 | 9 | 4 | 5 | 4.0 | CSc1ccc(C(=O)NC2CCC(NC(C)C)CC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2008.12.062 | |||
57344299 | 68978 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 552 | 7 | 3 | 3 | 5.6 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2ccc(C(F)(F)F)cc2)CC1 | nan | |||
CHEMBL1922818 | 68978 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 552 | 7 | 3 | 3 | 5.6 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2ccc(C(F)(F)F)cc2)CC1 | nan | |||
11467577 | 77671 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 606 | 8 | 2 | 5 | 5.9 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)Cc2nc3cccc(C(F)(F)F)c3[nH]2)[C@H](CS(=O)(=O)c2ccc(C(C)(C)C)cc2)C1 | 10.1016/j.bmcl.2012.08.002 | |||
CHEMBL2088382 | 77671 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 606 | 8 | 2 | 5 | 5.9 | CC(C)N(C)[C@@H]1CC[C@H](NC(=O)Cc2nc3cccc(C(F)(F)F)c3[nH]2)[C@H](CS(=O)(=O)c2ccc(C(C)(C)C)cc2)C1 | 10.1016/j.bmcl.2012.08.002 | |||
44453536 | 97982 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 435 | 7 | 2 | 4 | 2.8 | COc1ccccc1CN1CC[C@@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL272542 | 97982 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 435 | 7 | 2 | 4 | 2.8 | COc1ccccc1CN1CC[C@@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2008.02.015 | |||
22310899 | 22700 | None | 25 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 285 | 3 | 1 | 2 | 4.0 | O=C(O)c1cc2ccccc2n1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2003.10.049 | |||
CHEMBL132725 | 22700 | None | 25 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 285 | 3 | 1 | 2 | 4.0 | O=C(O)c1cc2ccccc2n1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2003.10.049 | |||
89823629 | 126389 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 521 | 5 | 1 | 5 | 4.1 | CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2C[C@@H]3C[C@H]2CN3c2cc(C)cc(C(F)(F)F)c2)C1 | nan | |||
CHEMBL3650369 | 126389 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 521 | 5 | 1 | 5 | 4.1 | CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2C[C@@H]3C[C@H]2CN3c2cc(C)cc(C(F)(F)F)c2)C1 | nan | |||
60148505 | 111173 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 469 | 4 | 1 | 6 | 2.3 | CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2OCC[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2014.03.036 | |||
CHEMBL3263268 | 111173 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 469 | 4 | 1 | 6 | 2.3 | CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2OCC[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2014.03.036 | |||
56643545 | 130691 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 520 | 7 | 3 | 3 | 4.9 | NC(=O)C(N[C@H]1CC[C@H](c2c[nH]c3ccccc32)CC1)C1CCN(C(=O)/C=C/c2cc(F)cc(F)c2)CC1 | nan | |||
CHEMBL3681870 | 130691 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 520 | 7 | 3 | 3 | 4.9 | NC(=O)C(N[C@H]1CC[C@H](c2c[nH]c3ccccc32)CC1)C1CCN(C(=O)/C=C/c2cc(F)cc(F)c2)CC1 | nan | |||
86767126 | 129477 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 545 | 5 | 1 | 6 | 4.1 | COC1COCCC1NC1CC2OC(c3ccccc3)CC2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | nan | |||
CHEMBL3671259 | 129477 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 545 | 5 | 1 | 6 | 4.1 | COC1COCCC1NC1CC2OC(c3ccccc3)CC2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | nan | |||
44415880 | 169442 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 550 | 7 | 1 | 2 | 7.1 | C[C@H]1CN(CC[C@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CC2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2006.07.011 | |||
CHEMBL441856 | 169442 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 550 | 7 | 1 | 2 | 7.1 | C[C@H]1CN(CC[C@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CC2)CC[C@@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2006.07.011 | |||
57396998 | 71038 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 491 | 6 | 3 | 6 | 2.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN([C@H]2CC[C@@](O)(c3cncnc3)CC2)C1 | 10.1021/ml200030q | |||
CHEMBL1951773 | 71038 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 491 | 6 | 3 | 6 | 2.2 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN([C@H]2CC[C@@](O)(c3cncnc3)CC2)C1 | 10.1021/ml200030q | |||
44425320 | 86169 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 713 | 9 | 2 | 6 | 7.9 | C[C@H]1CN(CCC(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2csc(NC(=O)c3cccnc3)n2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2006.10.059 | |||
CHEMBL231149 | 86169 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 713 | 9 | 2 | 6 | 7.9 | C[C@H]1CN(CCC(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2csc(NC(=O)c3cccnc3)n2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2006.10.059 | |||
44453366 | 158396 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 451 | 6 | 5 | 6 | 1.7 | Nc1cc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)ccc1O | 10.1016/j.bmcl.2008.02.015 | |||
CHEMBL408908 | 158396 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 451 | 6 | 5 | 6 | 1.7 | Nc1cc(CN2CC[C@@H](NC(=O)CNC(=O)c3cc(C(F)(F)F)ccc3N)C2)ccc1O | 10.1016/j.bmcl.2008.02.015 | |||
71768794 | 111166 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 545 | 5 | 1 | 6 | 4.1 | COC1COCCC1N[C@@H]1C[C@H]2OC(c3ccccc3)C[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2014.03.036 | |||
CHEMBL3263259 | 111166 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 545 | 5 | 1 | 6 | 4.1 | COC1COCCC1N[C@@H]1C[C@H]2OC(c3ccccc3)C[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2014.03.036 | |||
44425286 | 153336 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 670 | 9 | 2 | 6 | 8.2 | CC(C)(C)OC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
CHEMBL397750 | 153336 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 670 | 9 | 2 | 6 | 8.2 | CC(C)(C)OC(=O)Nc1nc([C@H](CCN2CCC(c3ccccc3)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
44593564 | 187338 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 498 | 6 | 2 | 3 | 5.3 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](NC2CCOCC2F)C1 | 10.1016/j.bmcl.2008.12.050 | |||
CHEMBL492564 | 187338 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 498 | 6 | 2 | 3 | 5.3 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](NC2CCOCC2F)C1 | 10.1016/j.bmcl.2008.12.050 | |||
44425258 | 169010 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 627 | 9 | 2 | 6 | 6.1 | CC(=O)Nc1nc(C(CCN2CCN(c3ccccc3C)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
CHEMBL438514 | 169010 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 627 | 9 | 2 | 6 | 6.1 | CC(=O)Nc1nc(C(CCN2CCN(c3ccccc3C)CC2)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cs1 | 10.1016/j.bmcl.2006.10.059 | |||
53322299 | 58691 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 459 | 6 | 1 | 4 | 3.1 | CC(C)[C@]1(C(=O)N2C[C@@H]3C[C@H]2CN3C(=O)CCC(F)(F)F)CC[C@@H](NC2CCOCC2)C1 | 10.1016/j.bmcl.2011.01.052 | |||
CHEMBL1684696 | 58691 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 459 | 6 | 1 | 4 | 3.1 | CC(C)[C@]1(C(=O)N2C[C@@H]3C[C@H]2CN3C(=O)CCC(F)(F)F)CC[C@@H](NC2CCOCC2)C1 | 10.1016/j.bmcl.2011.01.052 | |||
53326226 | 58703 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 463 | 6 | 1 | 4 | 3.3 | CC(C)[C@]1(C(=O)N2C[C@@H]3C[C@H]2CN3C(=O)CC2CCCC2)CC[C@@H](NC2CCOCC2F)C1 | 10.1016/j.bmcl.2011.01.052 | |||
CHEMBL1684709 | 58703 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 463 | 6 | 1 | 4 | 3.3 | CC(C)[C@]1(C(=O)N2C[C@@H]3C[C@H]2CN3C(=O)CC2CCCC2)CC[C@@H](NC2CCOCC2F)C1 | 10.1016/j.bmcl.2011.01.052 | |||
56675301 | 65777 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 439 | 7 | 3 | 5 | 3.1 | CCO[C@H]1CC[C@@H](N2CC(NC(=O)CNc3n[nH]c4ccc(C(F)(F)F)cc34)C2)CC1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834647 | 65777 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 439 | 7 | 3 | 5 | 3.1 | CCO[C@H]1CC[C@@H](N2CC(NC(=O)CNc3n[nH]c4ccc(C(F)(F)F)cc34)C2)CC1 | 10.1016/j.bmcl.2011.08.074 | |||
44444110 | 154931 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 486 | 7 | 1 | 3 | 6.2 | COc1ccc(C2CCN(CC3CCC(NC(=O)/C=C/c4ccc(Cl)c(Cl)c4)C3)CC2)cc1 | 10.1016/j.bmcl.2007.07.065 | |||
CHEMBL400483 | 154931 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 486 | 7 | 1 | 3 | 6.2 | COc1ccc(C2CCN(CC3CCC(NC(=O)/C=C/c4ccc(Cl)c(Cl)c4)C3)CC2)cc1 | 10.1016/j.bmcl.2007.07.065 | |||
11844469 | 78433 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 566 | 9 | 1 | 2 | 8.3 | C[C@H]1CN(CC[C@H](CNCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccc(F)cc2)CC[C@@H]1c1ccccc1 | 10.1021/jm060439n | |||
CHEMBL211092 | 78433 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 566 | 9 | 1 | 2 | 8.3 | C[C@H]1CN(CC[C@H](CNCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccc(F)cc2)CC[C@@H]1c1ccccc1 | 10.1021/jm060439n | |||
89823497 | 126370 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 509 | 5 | 1 | 7 | 2.6 | CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2C[C@@H]3C[C@H]2CN3c2cc(C(F)(F)F)cnn2)C1 | nan | |||
CHEMBL3650350 | 126370 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 509 | 5 | 1 | 7 | 2.6 | CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2C[C@@H]3C[C@H]2CN3c2cc(C(F)(F)F)cnn2)C1 | nan | |||
56676473 | 65829 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 489 | 6 | 2 | 7 | 3.3 | Cn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](c4nccn4C)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834850 | 65829 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 489 | 6 | 2 | 7 | 3.3 | Cn1nc(NCC(=O)NC2CN([C@H]3CC[C@@H](c4nccn4C)CC3)C2)c2cc(C(F)(F)F)ccc21 | 10.1016/j.bmcl.2011.08.074 | |||
44444106 | 94126 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 490 | 5 | 0 | 2 | 6.5 | O=C(/C=C/c1cccc(C(F)(F)F)c1)N1CCC(CN2CCC(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.07.065 | |||
CHEMBL249010 | 94126 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 490 | 5 | 0 | 2 | 6.5 | O=C(/C=C/c1cccc(C(F)(F)F)c1)N1CCC(CN2CCC(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.07.065 | |||
44395144 | 67014 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 399 | 7 | 2 | 3 | 3.2 | Cc1cccc(C(=O)NCC(=O)NCC2CCCN2Cc2ccc(Cl)cc2)c1 | 10.1016/j.bmcl.2004.08.009 | |||
CHEMBL186878 | 67014 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 399 | 7 | 2 | 3 | 3.2 | Cc1cccc(C(=O)NCC(=O)NCC2CCCN2Cc2ccc(Cl)cc2)c1 | 10.1016/j.bmcl.2004.08.009 | |||
44593563 | 193219 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 508 | 7 | 2 | 3 | 5.9 | CCC1COCCC1N[C@@H]1CC[C@@](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(C(C)C)C1 | 10.1016/j.bmcl.2008.12.050 | |||
CHEMBL522688 | 193219 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 508 | 7 | 2 | 3 | 5.9 | CCC1COCCC1N[C@@H]1CC[C@@](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(C(C)C)C1 | 10.1016/j.bmcl.2008.12.050 | |||
46884856 | 8346 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 566 | 8 | 2 | 4 | 3.8 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCC2CCN(C(=O)c3cc(F)ccc3F)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
CHEMBL1092921 | 8346 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 566 | 8 | 2 | 4 | 3.8 | O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCC2CCN(C(=O)c3cc(F)ccc3F)CC2)C1 | 10.1016/j.bmcl.2010.02.072 | |||
89823512 | 126422 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 589 | 5 | 0 | 5 | 5.2 | CO[C@@H]1COCC[C@@H]1N(C)[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2C[C@@H]3C[C@H]2CN3c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 | nan | |||
CHEMBL3650400 | 126422 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 589 | 5 | 0 | 5 | 5.2 | CO[C@@H]1COCC[C@@H]1N(C)[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2C[C@@H]3C[C@H]2CN3c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 | nan | |||
10414966 | 155208 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 542 | 6 | 1 | 4 | 6.2 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CCC(c3ncccn3)CC2)C1 | 10.1016/j.bmcl.2007.12.029 | |||
CHEMBL402010 | 155208 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 542 | 6 | 1 | 4 | 6.2 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CCC(c3ncccn3)CC2)C1 | 10.1016/j.bmcl.2007.12.029 | |||
89823482 | 126373 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 522 | 5 | 1 | 6 | 3.6 | CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2[C@H]3CC[C@@H]2CN(c2cc(C(F)(F)F)ccn2)C3)C1 | nan | |||
CHEMBL3650353 | 126373 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 522 | 5 | 1 | 6 | 3.6 | CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2[C@H]3CC[C@@H]2CN(c2cc(C(F)(F)F)ccn2)C3)C1 | nan | |||
70696469 | 75240 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 372 | 5 | 1 | 4 | 2.7 | COc1ccc(NC(=O)N2CCN(C[C@@H]3CCCN(C4CC4)C3)CC2)cc1 | 10.1016/j.bmcl.2012.04.118 | |||
CHEMBL2036765 | 75240 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 372 | 5 | 1 | 4 | 2.7 | COc1ccc(NC(=O)N2CCN(C[C@@H]3CCCN(C4CC4)C3)CC2)cc1 | 10.1016/j.bmcl.2012.04.118 | |||
44425649 | 86163 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 554 | 6 | 1 | 2 | 7.5 | C[C@H]1CN(C2CCC(CC3CCC3)(C(=O)NCc3cc(F)cc(C(F)(F)F)c3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2007.04.053 | |||
CHEMBL231142 | 86163 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 554 | 6 | 1 | 2 | 7.5 | C[C@H]1CN(C2CCC(CC3CCC3)(C(=O)NCc3cc(F)cc(C(F)(F)F)c3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2007.04.053 | |||
89823499 | 126376 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 522 | 5 | 1 | 6 | 3.5 | CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2C[C@@H]3C[C@H]2CN3c2cc(C(F)(F)F)cc(C)n2)C1 | nan | |||
CHEMBL3650356 | 126376 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 522 | 5 | 1 | 6 | 3.5 | CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2C[C@@H]3C[C@H]2CN3c2cc(C(F)(F)F)cc(C)n2)C1 | nan | |||
44413230 | 139184 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 447 | 8 | 2 | 3 | 4.2 | CN(C)CCNC(C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2006.04.045 | |||
CHEMBL378658 | 139184 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 447 | 8 | 2 | 3 | 4.2 | CN(C)CCNC(C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 | 10.1016/j.bmcl.2006.04.045 | |||
89823444 | 126394 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 523 | 6 | 1 | 6 | 3.7 | CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2C[C@@H]3C[C@H]2CN3c2cccc(OC(F)(F)F)c2)C1 | nan | |||
CHEMBL3650374 | 126394 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 523 | 6 | 1 | 6 | 3.7 | CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2C[C@@H]3C[C@H]2CN3c2cccc(OC(F)(F)F)c2)C1 | nan | |||
44353334 | 117507 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 319 | 3 | 1 | 2 | 4.7 | O=C(O)c1cc2cc(Cl)ccc2n1Cc1ccccc1Cl | 10.1016/j.bmcl.2003.10.049 | |||
CHEMBL339842 | 117507 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 319 | 3 | 1 | 2 | 4.7 | O=C(O)c1cc2cc(Cl)ccc2n1Cc1ccccc1Cl | 10.1016/j.bmcl.2003.10.049 | |||
57343917 | 130698 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 526 | 7 | 3 | 4 | 4.5 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2ccc3c(c2)CCO3)CC1 | nan | |||
CHEMBL3681877 | 130698 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 526 | 7 | 3 | 4 | 4.5 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)/C=C/c2ccc3c(c2)CCO3)CC1 | nan | |||
54769305 | 86614 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 483 | 6 | 2 | 5 | 4.6 | O=C(CNc1ncnc2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](c3ccccc3)CC2)C1 | 10.1016/j.bmcl.2012.12.017 | |||
CHEMBL2315920 | 86614 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 483 | 6 | 2 | 5 | 4.6 | O=C(CNc1ncnc2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@H](c3ccccc3)CC2)C1 | 10.1016/j.bmcl.2012.12.017 | |||
68003962 | 86615 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 499 | 6 | 3 | 6 | 3.7 | O=C(CNc1ncnc2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@](O)(c3ccccc3)CC2)C1 | 10.1016/j.bmcl.2012.12.017 | |||
CHEMBL2315921 | 86615 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 499 | 6 | 3 | 6 | 3.7 | O=C(CNc1ncnc2ccc(C(F)(F)F)cc12)NC1CN([C@H]2CC[C@@](O)(c3ccccc3)CC2)C1 | 10.1016/j.bmcl.2012.12.017 | |||
49764446 | 65461 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 518 | 7 | 3 | 5 | 3.1 | CN(C)c1cccc([C@]2(O)CC[C@@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)c1 | 10.1016/j.bmcl.2011.06.080 | |||
CHEMBL1829631 | 65461 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 518 | 7 | 3 | 5 | 3.1 | CN(C)c1cccc([C@]2(O)CC[C@@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)c1 | 10.1016/j.bmcl.2011.06.080 | |||
54755560 | 65800 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 495 | 8 | 2 | 7 | 3.4 | CCOC(=O)[C@H]1CC[C@@H](N2CC(NC(=O)CNc3nn(CC)c4ccc(C(F)(F)F)cc34)C2)CC1 | 10.1016/j.bmcl.2011.08.074 | |||
CHEMBL1834721 | 65800 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 495 | 8 | 2 | 7 | 3.4 | CCOC(=O)[C@H]1CC[C@@H](N2CC(NC(=O)CNc3nn(CC)c4ccc(C(F)(F)F)cc34)C2)CC1 | 10.1016/j.bmcl.2011.08.074 | |||
44415922 | 141770 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 536 | 7 | 1 | 2 | 6.8 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC2(C=Cc3ccccc32)CC1)C1CC1 | 10.1016/j.bmcl.2006.07.011 | |||
CHEMBL385540 | 141770 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 536 | 7 | 1 | 2 | 6.8 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC2(C=Cc3ccccc32)CC1)C1CC1 | 10.1016/j.bmcl.2006.07.011 | |||
24794624 | 179722 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 492 | 6 | 3 | 6 | 3.1 | CC(=O)N[C@@H]1C[C@H](NC(C)C)CC[C@@H]1N1CC[C@H](Nc2ncnc3ccc(C(F)(F)F)cc23)C1=O | 10.1021/acsmedchemlett.1c00082 | |||
CHEMBL4742683 | 179722 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 492 | 6 | 3 | 6 | 3.1 | CC(=O)N[C@@H]1C[C@H](NC(C)C)CC[C@@H]1N1CC[C@H](Nc2ncnc3ccc(C(F)(F)F)cc23)C1=O | 10.1021/acsmedchemlett.1c00082 | |||
162657824 | 181232 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 482 | 5 | 3 | 4 | 2.9 | CC(=O)N[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1N1CC[C@H](NC(=O)c2cccc(C(F)(F)F)c2)C1=O | 10.1021/acsmedchemlett.1c00082 | |||
CHEMBL4760566 | 181232 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 482 | 5 | 3 | 4 | 2.9 | CC(=O)N[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1N1CC[C@H](NC(=O)c2cccc(C(F)(F)F)c2)C1=O | 10.1021/acsmedchemlett.1c00082 | |||
53326701 | 58482 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 497 | 6 | 1 | 5 | 3.9 | CO[C@H]1COCC[C@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cccc(C(F)(F)F)c3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.015 | |||
CHEMBL1683068 | 58482 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 497 | 6 | 1 | 5 | 3.9 | CO[C@H]1COCC[C@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cccc(C(F)(F)F)c3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.015 | |||
44425633 | 86075 | None | 0 | Mouse | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 578 | 5 | 1 | 2 | 7.8 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2007.04.053 | |||
CHEMBL230721 | 86075 | None | 0 | Mouse | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 578 | 5 | 1 | 2 | 7.8 | CC(C)[C@]1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H](N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2007.04.053 | |||
44425648 | 168807 | None | 0 | Mouse | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 540 | 6 | 1 | 2 | 7.1 | C[C@H]1CN(C2CCC(CC3CC3)(C(=O)NCc3cc(F)cc(C(F)(F)F)c3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2007.04.053 | |||
CHEMBL436796 | 168807 | None | 0 | Mouse | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 540 | 6 | 1 | 2 | 7.1 | C[C@H]1CN(C2CCC(CC3CC3)(C(=O)NCc3cc(F)cc(C(F)(F)F)c3)C2)CC[C@]12C=Cc1ccccc12 | 10.1016/j.bmcl.2007.04.053 | |||
44442590 | 93825 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 606 | 11 | 6 | 5 | 3.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL247455 | 93825 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 606 | 11 | 6 | 5 | 3.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
11553489 | 121285 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 417 | 11 | 4 | 4 | 2.3 | CCC[C@H](O)[C@H](CNCC(C)C)NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1021/ml500505q | |||
CHEMBL3577929 | 121285 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 417 | 11 | 4 | 4 | 2.3 | CCC[C@H](O)[C@H](CNCC(C)C)NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1021/ml500505q | |||
11497533 | 89223 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 539 | 6 | 2 | 3 | 5.8 | O=C(O)C(C1CCN(C(=O)/C=C/c2ccc(C(F)(F)F)cc2)CC1)N1CCC(c2c[nH]c3ccccc23)CC1 | 10.1021/jm070902b | |||
CHEMBL236722 | 89223 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 539 | 6 | 2 | 3 | 5.8 | O=C(O)C(C1CCN(C(=O)/C=C/c2ccc(C(F)(F)F)cc2)CC1)N1CCC(c2c[nH]c3ccccc23)CC1 | 10.1021/jm070902b | |||
11541149 | 146399 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 541 | 6 | 3 | 4 | 4.9 | O=C(O)C(C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1)N1CCC(c2c[nH]c3ccc(O)cc23)CC1 | 10.1021/jm070902b | |||
CHEMBL392097 | 146399 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 541 | 6 | 3 | 4 | 4.9 | O=C(O)C(C1CCN(C(=O)/C=C/c2cc(F)c(F)c(F)c2)CC1)N1CCC(c2c[nH]c3ccc(O)cc23)CC1 | 10.1021/jm070902b | |||
53323664 | 58708 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 463 | 5 | 1 | 4 | 3.3 | CC(C)[C@]1(C(=O)N2C[C@@H]3C[C@H]2CN3C(=O)C2CCCCC2)CC[C@@H](NC2CCOCC2F)C1 | 10.1016/j.bmcl.2011.01.052 | |||
CHEMBL1684714 | 58708 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 463 | 5 | 1 | 4 | 3.3 | CC(C)[C@]1(C(=O)N2C[C@@H]3C[C@H]2CN3C(=O)C2CCCCC2)CC[C@@H](NC2CCOCC2F)C1 | 10.1016/j.bmcl.2011.01.052 | |||
54583187 | 62594 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 484 | 5 | 2 | 6 | 2.7 | CC(C)[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)CC[C@@H](N[C@H]2CCOC[C@H]2O)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782580 | 62594 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 484 | 5 | 2 | 6 | 2.7 | CC(C)[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)CC[C@@H](N[C@H]2CCOC[C@H]2O)C1 | 10.1016/j.bmcl.2011.01.034 | |||
44425639 | 86099 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 580 | 6 | 1 | 3 | 6.8 | COCC1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCC(N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2007.04.053 | |||
CHEMBL230831 | 86099 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 580 | 6 | 1 | 3 | 6.8 | COCC1(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCC(N2CC[C@]3(C=Cc4ccccc43)[C@@H](C)C2)C1 | 10.1016/j.bmcl.2007.04.053 | |||
54580190 | 62591 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 512 | 7 | 1 | 6 | 3.7 | CCO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782577 | 62591 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 512 | 7 | 1 | 6 | 3.7 | CCO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
54582215 | 62580 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 498 | 6 | 1 | 6 | 3.3 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cncc(C(F)(F)F)c3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782566 | 62580 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 498 | 6 | 1 | 6 | 3.3 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cncc(C(F)(F)F)c3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
54581190 | 62582 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 499 | 6 | 1 | 7 | 2.7 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cncc(C(F)(F)F)n3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
CHEMBL1782568 | 62582 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 499 | 6 | 1 | 7 | 2.7 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cncc(C(F)(F)F)n3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.034 | |||
162658125 | 181202 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 471 | 6 | 2 | 4 | 5.9 | O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
CHEMBL4760108 | 181202 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 471 | 6 | 2 | 4 | 5.9 | O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
57344216 | 130699 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 541 | 6 | 4 | 3 | 5.6 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)Nc2cccc(C(F)(F)F)c2)CC1 | nan | |||
CHEMBL3681878 | 130699 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 541 | 6 | 4 | 3 | 5.6 | NC(=O)C(NC1CCC(c2c[nH]c3ccccc23)CC1)C1CCN(C(=O)Nc2cccc(C(F)(F)F)c2)CC1 | nan | |||
71517241 | 86413 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 485 | 4 | 1 | 5 | 3.3 | COC1COCCC1N[C@@H]1C[C@H]2C[C@@H](F)C[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2012.10.069 | |||
CHEMBL2313771 | 86413 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 485 | 4 | 1 | 5 | 3.3 | COC1COCCC1N[C@@H]1C[C@H]2C[C@@H](F)C[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2012.10.069 | |||
127025460 | 137416 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 437 | 4 | 1 | 3 | 5.1 | C[C@H]1CC=C(C(=O)NS(=O)(=O)c2ccccc2)[C@](C)(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/j.bmcl.2015.11.051 | |||
CHEMBL3752690 | 137416 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 437 | 4 | 1 | 3 | 5.1 | C[C@H]1CC=C(C(=O)NS(=O)(=O)c2ccccc2)[C@](C)(c2ccc(Cl)c(Cl)c2)C1 | 10.1016/j.bmcl.2015.11.051 | |||
10165716 | 93607 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 538 | 10 | 4 | 5 | 3.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(SC(F)(F)F)c2)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL246417 | 93607 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 538 | 10 | 4 | 5 | 3.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(SC(F)(F)F)c2)C(=O)NC(C)(C)C)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
44442559 | 93784 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 532 | 10 | 4 | 4 | 3.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(=O)NC2CCCCC2)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL247208 | 93784 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 532 | 10 | 4 | 4 | 3.8 | Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)C(=O)NC2CCCCC2)c(C)c1 | 10.1016/j.bmcl.2007.07.028 | |||
44442547 | 154982 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 506 | 11 | 3 | 4 | 3.2 | CCNC(=O)[C@H](CCN(C)Cc1ccc(C)cc1C)NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL400793 | 154982 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 506 | 11 | 3 | 4 | 3.2 | CCNC(=O)[C@H](CCN(C)Cc1ccc(C)cc1C)NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.07.028 | |||
9873546 | 78066 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 566 | 8 | 1 | 2 | 7.5 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(c2ccccc2)CC1)c1ccc(F)cc1 | 10.1021/jm060439n | |||
CHEMBL209899 | 78066 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 566 | 8 | 1 | 2 | 7.5 | O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(c2ccccc2)CC1)c1ccc(F)cc1 | 10.1021/jm060439n | |||
22310976 | 117111 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 353 | 3 | 1 | 2 | 5.3 | O=C(O)c1cc2c(Cl)cccc2n1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2003.10.049 | |||
CHEMBL339099 | 117111 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 353 | 3 | 1 | 2 | 5.3 | O=C(O)c1cc2c(Cl)cccc2n1Cc1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2003.10.049 | |||
71519050 | 86426 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 444 | 5 | 1 | 7 | 2.2 | COC1COCCC1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2CCc3ncc([N+](=O)[O-])cc3C2)C1 | 10.1016/j.bmcl.2012.10.069 | |||
CHEMBL2313785 | 86426 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 444 | 5 | 1 | 7 | 2.2 | COC1COCCC1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2CCc3ncc([N+](=O)[O-])cc3C2)C1 | 10.1016/j.bmcl.2012.10.069 | |||
44395048 | 66182 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 495 | 8 | 3 | 6 | 2.9 | NS(=O)(=O)c1ccc(CN2CCCN(CCC(O)(c3ccccc3)c3cccc(O)c3)CC2)cc1 | 10.1016/j.bmcl.2004.08.008 | |||
CHEMBL184256 | 66182 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 495 | 8 | 3 | 6 | 2.9 | NS(=O)(=O)c1ccc(CN2CCCN(CCC(O)(c3ccccc3)c3cccc(O)c3)CC2)cc1 | 10.1016/j.bmcl.2004.08.008 | |||
44395062 | 66719 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 512 | 8 | 2 | 6 | 3.8 | CS(=O)(=O)c1ccc(CN2CCCN(CCC(O)(c3ccc(F)cc3)c3cccc(O)c3)CC2)cc1 | 10.1016/j.bmcl.2004.08.008 | |||
CHEMBL185517 | 66719 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 512 | 8 | 2 | 6 | 3.8 | CS(=O)(=O)c1ccc(CN2CCCN(CCC(O)(c3ccc(F)cc3)c3cccc(O)c3)CC2)cc1 | 10.1016/j.bmcl.2004.08.008 | |||
44395028 | 66976 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 528 | 8 | 2 | 6 | 4.3 | CS(=O)(=O)c1ccc(CN2CCCN(CCC(O)(c3ccc(Cl)cc3)c3cccc(O)c3)CC2)cc1 | 10.1016/j.bmcl.2004.08.008 | |||
CHEMBL186689 | 66976 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 528 | 8 | 2 | 6 | 4.3 | CS(=O)(=O)c1ccc(CN2CCCN(CCC(O)(c3ccc(Cl)cc3)c3cccc(O)c3)CC2)cc1 | 10.1016/j.bmcl.2004.08.008 | |||
44395061 | 66421 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 510 | 8 | 3 | 7 | 3.3 | CS(=O)(=O)c1ccc(CN2CCCN(CCC(O)(c3cccc(O)c3)c3cccc(O)c3)CC2)cc1 | 10.1016/j.bmcl.2004.08.008 | |||
CHEMBL185180 | 66421 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 510 | 8 | 3 | 7 | 3.3 | CS(=O)(=O)c1ccc(CN2CCCN(CCC(O)(c3cccc(O)c3)c3cccc(O)c3)CC2)cc1 | 10.1016/j.bmcl.2004.08.008 | |||
9825735 | 93817 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 465 | 9 | 3 | 5 | 2.5 | COC(=O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL247405 | 93817 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 465 | 9 | 3 | 5 | 2.5 | COC(=O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2007.07.028 | |||
44444032 | 94161 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 474 | 10 | 1 | 3 | 6.2 | COc1ccc(C2CCN(CCCCCNC(=O)/C=C/c3ccc(Cl)c(Cl)c3)CC2)cc1 | 10.1016/j.bmcl.2007.07.065 | |||
CHEMBL249183 | 94161 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 474 | 10 | 1 | 3 | 6.2 | COc1ccc(C2CCN(CCCCCNC(=O)/C=C/c3ccc(Cl)c(Cl)c3)CC2)cc1 | 10.1016/j.bmcl.2007.07.065 | |||
11844467 | 77940 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 566 | 9 | 1 | 2 | 8.4 | CC(C[C@H](CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccc(F)cc1)N1CCC(c2ccccc2)CC1 | 10.1021/jm060439n | |||
CHEMBL209423 | 77940 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 566 | 9 | 1 | 2 | 8.4 | CC(C[C@H](CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccc(F)cc1)N1CCC(c2ccccc2)CC1 | 10.1021/jm060439n | |||
44442540 | 93539 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 465 | 9 | 3 | 5 | 2.5 | COC(=O)[C@@H](CNC(=O)CNC(=O)c1cccc(C(F)(F)F)c1)NCc1ccc(C)cc1C | 10.1016/j.bmcl.2007.07.028 | |||
CHEMBL246218 | 93539 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 465 | 9 | 3 | 5 | 2.5 | COC(=O)[C@@H](CNC(=O)CNC(=O)c1cccc(C(F)(F)F)c1)NCc1ccc(C)cc1C | 10.1016/j.bmcl.2007.07.028 | |||
46886537 | 8350 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 511 | 8 | 1 | 5 | 3.4 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3ccccc3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2010.03.035 | |||
CHEMBL1092940 | 8350 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 511 | 8 | 1 | 5 | 3.4 | CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3ccccc3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1 | 10.1016/j.bmcl.2010.03.035 | |||
76321527 | 105310 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 551 | 5 | 1 | 8 | 3.1 | COC1COCCC1N[C@@H]1C[C@H]2CN(c3nccs3)C[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2013.05.024 | |||
CHEMBL3115269 | 105310 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 551 | 5 | 1 | 8 | 3.1 | COC1COCCC1N[C@@H]1C[C@H]2CN(c3nccs3)C[C@@]2(C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)C1 | 10.1016/j.bmcl.2013.05.024 | |||
89823389 | 126408 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 575 | 5 | 1 | 5 | 4.9 | CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2C[C@@H]3C[C@H]2CN3c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 | nan | |||
CHEMBL3650388 | 126408 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 575 | 5 | 1 | 5 | 4.9 | CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@@]2(C(=O)N2C[C@@H]3C[C@H]2CN3c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 | nan | |||
71518407 |