Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
| 24861391 | 188859 | None | 0 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -2 | 2 | ChEMBL | 578 | 5 | 1 | 7 | 5.3 | O=C(O)c1cc(N2CCN(C(=O)c3cn(-c4ccc5c(c4)OCCO5)c(-c4ccc(F)cc4)n3)CC2)cc2ccccc12 | 10.1016/j.bmcl.2008.06.057 | |||
| CHEMBL505225 | 188859 | None | 0 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -2 | 2 | ChEMBL | 578 | 5 | 1 | 7 | 5.3 | O=C(O)c1cc(N2CCN(C(=O)c3cn(-c4ccc5c(c4)OCCO5)c(-c4ccc(F)cc4)n3)CC2)cc2ccccc12 | 10.1016/j.bmcl.2008.06.057 | |||
| CHEMBL505969 | 188859 | None | 0 | Mouse | Functional | pEC50 | = | 9.9 | 9.9 | -2 | 2 | ChEMBL | 578 | 5 | 1 | 7 | 5.3 | O=C(O)c1cc(N2CCN(C(=O)c3cn(-c4ccc5c(c4)OCCO5)c(-c4ccc(F)cc4)n3)CC2)cc2ccccc12 | 10.1016/j.bmcl.2008.06.057 | |||
| CHEMBL2369765 | 212141 | None | 13 | Rat | Functional | pEC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm101279a | |||||
| CHEMBL1806528 | 211433 | None | 0 | Rat | Functional | pEC50 | = | 9.6 | 9.6 | 13 | 2 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm101279a | |||||
| 155533399 | 171948 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | 2 | 2 | ChEMBL | 1838 | 72 | 19 | 24 | 1.4 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4468861 | 171948 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | 2 | 2 | ChEMBL | 1838 | 72 | 19 | 24 | 1.4 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 24861060 | 188834 | None | 0 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -5 | 3 | ChEMBL | 578 | 7 | 1 | 6 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.06.057 | |||
| CHEMBL446789 | 188834 | None | 0 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -5 | 3 | ChEMBL | 578 | 7 | 1 | 6 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.06.057 | |||
| CHEMBL504861 | 188834 | None | 0 | Mouse | Functional | pEC50 | = | 9.5 | 9.5 | -5 | 3 | ChEMBL | 578 | 7 | 1 | 6 | 6.2 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 | 10.1016/j.bmcl.2008.06.057 | |||
| 155564367 | 175260 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | 457 | 2 | ChEMBL | 1836 | 72 | 18 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4570130 | 175260 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | 457 | 2 | ChEMBL | 1836 | 72 | 18 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 155543846 | 173315 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | 14 | 2 | ChEMBL | 1838 | 72 | 19 | 24 | 2.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4522865 | 173315 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | 14 | 2 | ChEMBL | 1838 | 72 | 19 | 24 | 2.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 56663263 | 64039 | None | 0 | Rat | Functional | pEC50 | = | 9.5 | 9.5 | 7 | 2 | ChEMBL | 1538 | 51 | 14 | 25 | -2.8 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NCCOCCOCCOCCOCCOCCOC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm101279a | |||
| CHEMBL1807150 | 64039 | None | 0 | Rat | Functional | pEC50 | = | 9.5 | 9.5 | 7 | 2 | ChEMBL | 1538 | 51 | 14 | 25 | -2.8 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NCCOCCOCCOCCOCCOCCOC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm101279a | |||
| 155553502 | 174279 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | 26 | 2 | ChEMBL | 1822 | 72 | 19 | 22 | 3.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4547294 | 174279 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | 26 | 2 | ChEMBL | 1822 | 72 | 19 | 22 | 3.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 155540415 | 173042 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | 1584 | 2 | ChEMBL | 1862 | 71 | 17 | 23 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4516868 | 173042 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | 1584 | 2 | ChEMBL | 1862 | 71 | 17 | 23 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 155557285 | 174622 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | 295 | 2 | ChEMBL | 1779 | 74 | 19 | 22 | 1.6 | CCCC[C@H](NC(=O)[C@H](CNC(=O)CCCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4555341 | 174622 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | 295 | 2 | ChEMBL | 1779 | 74 | 19 | 22 | 1.6 | CCCC[C@H](NC(=O)[C@H](CNC(=O)CCCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 5311400 | 3293 | None | 0 | Rat | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0000416 | |||||
| 900 | 3293 | None | 0 | Rat | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0000416 | |||||
| CHEMBL262197 | 3293 | None | 0 | Rat | Functional | pEC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | None | None | None | None | 10.1021/jm0000416 | |||||
| 155559320 | 174968 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -1 | 2 | ChEMBL | 1872 | 72 | 18 | 23 | 3.8 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4563364 | 174968 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -1 | 2 | ChEMBL | 1872 | 72 | 18 | 23 | 3.8 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL1806532 | 211436 | None | 0 | Rat | Functional | pEC50 | = | 9.4 | 9.4 | 5 | 2 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm101279a | |||||
| 155526914 | 171305 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -2 | 2 | ChEMBL | 1837 | 72 | 19 | 24 | 0.8 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4459331 | 171305 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -2 | 2 | ChEMBL | 1837 | 72 | 19 | 24 | 0.8 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 155546692 | 173746 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | 3 | 2 | ChEMBL | 1861 | 72 | 19 | 23 | 3.2 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4534236 | 173746 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | 3 | 2 | ChEMBL | 1861 | 72 | 19 | 23 | 3.2 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 9853654 | 22797 | None | 34 | Rat | Functional | pEC50 | = | 9.4 | 9.4 | -1 | 4 | ChEMBL | 767 | 20 | 8 | 9 | 1.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.0c01233 | |||
| CHEMBL1328 | 22797 | None | 34 | Rat | Functional | pEC50 | = | 9.4 | 9.4 | -1 | 4 | ChEMBL | 767 | 20 | 8 | 9 | 1.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.0c01233 | |||
| 155516677 | 170192 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -1 | 2 | ChEMBL | 1822 | 72 | 18 | 23 | 2.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4443415 | 170192 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -1 | 2 | ChEMBL | 1822 | 72 | 18 | 23 | 2.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 155558199 | 174873 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | 15488 | 2 | ChEMBL | 1894 | 75 | 19 | 24 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4561184 | 174873 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | 15488 | 2 | ChEMBL | 1894 | 75 | 19 | 24 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 155524181 | 170956 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -4 | 2 | ChEMBL | 1820 | 71 | 18 | 22 | 2.7 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4453982 | 170956 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -4 | 2 | ChEMBL | 1820 | 71 | 18 | 22 | 2.7 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 101823779 | 1396 | None | 27 | Human | Functional | pEC50 | = | 9.3 | 9.3 | 354 | 2 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | |||||
| 16162108 | 1396 | None | 27 | Human | Functional | pEC50 | = | 9.3 | 9.3 | 354 | 2 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | |||||
| 8408 | 1396 | None | 27 | Human | Functional | pEC50 | = | 9.3 | 9.3 | 354 | 2 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | |||||
| CHEMBL4451154 | 1396 | None | 27 | Human | Functional | pEC50 | = | 9.3 | 9.3 | 354 | 2 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | |||||
| 155555346 | 174476 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -3 | 2 | ChEMBL | 1836 | 71 | 17 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4551834 | 174476 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -3 | 2 | ChEMBL | 1836 | 71 | 17 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 4627 | 822 | None | 42 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -1 | 6 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | |||||
| 864 | 822 | None | 42 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -1 | 6 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | |||||
| 9833444 | 822 | None | 42 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -1 | 6 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | |||||
| CHEMBL1121 | 822 | None | 42 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -1 | 6 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | |||||
| DB09142 | 822 | None | 42 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -1 | 6 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | |||||
| 155544674 | 175040 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -1 | 2 | ChEMBL | 1822 | 71 | 18 | 23 | 2.5 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4565336 | 175040 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -1 | 2 | ChEMBL | 1822 | 71 | 18 | 23 | 2.5 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 10509035 | 14515 | None | 0 | Rat | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 714 | 19 | 7 | 8 | 0.3 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CS(=O)(=O)O | 10.1021/jm0000416 | |||
| CHEMBL120150 | 14515 | None | 0 | Rat | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 714 | 19 | 7 | 8 | 0.3 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CS(=O)(=O)O | 10.1021/jm0000416 | |||
| 4627 | 822 | None | 42 | Rat | Functional | pEC50 | = | 9.2 | 9.2 | -6 | 6 | ChEMBL | None | None | None | None | 10.1021/jm0000416 | |||||
| 864 | 822 | None | 42 | Rat | Functional | pEC50 | = | 9.2 | 9.2 | -6 | 6 | ChEMBL | None | None | None | None | 10.1021/jm0000416 | |||||
| 9833444 | 822 | None | 42 | Rat | Functional | pEC50 | = | 9.2 | 9.2 | -6 | 6 | ChEMBL | None | None | None | None | 10.1021/jm0000416 | |||||
| CHEMBL1121 | 822 | None | 42 | Rat | Functional | pEC50 | = | 9.2 | 9.2 | -6 | 6 | ChEMBL | None | None | None | None | 10.1021/jm0000416 | |||||
| DB09142 | 822 | None | 42 | Rat | Functional | pEC50 | = | 9.2 | 9.2 | -6 | 6 | ChEMBL | None | None | None | None | 10.1021/jm0000416 | |||||
| 4627 | 822 | None | 42 | Rat | Functional | pEC50 | = | 9.2 | 9.2 | -6 | 6 | ChEMBL | None | None | None | None | 10.1021/jm9603072 | |||||
| 864 | 822 | None | 42 | Rat | Functional | pEC50 | = | 9.2 | 9.2 | -6 | 6 | ChEMBL | None | None | None | None | 10.1021/jm9603072 | |||||
| 9833444 | 822 | None | 42 | Rat | Functional | pEC50 | = | 9.2 | 9.2 | -6 | 6 | ChEMBL | None | None | None | None | 10.1021/jm9603072 | |||||
| CHEMBL1121 | 822 | None | 42 | Rat | Functional | pEC50 | = | 9.2 | 9.2 | -6 | 6 | ChEMBL | None | None | None | None | 10.1021/jm9603072 | |||||
| DB09142 | 822 | None | 42 | Rat | Functional | pEC50 | = | 9.2 | 9.2 | -6 | 6 | ChEMBL | None | None | None | None | 10.1021/jm9603072 | |||||
| 155532425 | 171851 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -3 | 2 | ChEMBL | 1822 | 71 | 18 | 23 | 2.5 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4467338 | 171851 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -3 | 2 | ChEMBL | 1822 | 71 | 18 | 23 | 2.5 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.8b01558 | |||
| 16755781 | 188893 | None | 9 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -9 | 3 | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
| CHEMBL443189 | 188893 | None | 9 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -9 | 3 | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
| CHEMBL505409 | 188893 | None | 9 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -9 | 3 | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
| CHEMBL505727 | 188893 | None | 9 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | -9 | 3 | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
| 155517868 | 170314 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | 457 | 2 | ChEMBL | 1893 | 76 | 19 | 24 | 3.2 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4445353 | 170314 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | 457 | 2 | ChEMBL | 1893 | 76 | 19 | 24 | 3.2 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL64605 | 218346 | None | 5 | Rat | Functional | pEC50 | = | 9 | 9.0 | 3 | 4 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm0000416 | |||||
| 162658676 | 181088 | None | 0 | Rat | Functional | pEC50 | = | 8.9 | 8.9 | 3 | 2 | ChEMBL | 1489 | 37 | 14 | 19 | -0.7 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/acs.jmedchem.0c01233 | |||
| CHEMBL4758706 | 181088 | None | 0 | Rat | Functional | pEC50 | = | 8.9 | 8.9 | 3 | 2 | ChEMBL | 1489 | 37 | 14 | 19 | -0.7 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/acs.jmedchem.0c01233 | |||
| 16755781 | 188893 | None | 9 | Mouse | Functional | pEC50 | = | 8.9 | 8.9 | -9 | 3 | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
| CHEMBL443189 | 188893 | None | 9 | Mouse | Functional | pEC50 | = | 8.9 | 8.9 | -9 | 3 | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
| CHEMBL505409 | 188893 | None | 9 | Mouse | Functional | pEC50 | = | 8.9 | 8.9 | -9 | 3 | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
| CHEMBL505727 | 188893 | None | 9 | Mouse | Functional | pEC50 | = | 8.9 | 8.9 | -9 | 3 | ChEMBL | 560 | 7 | 1 | 6 | 6.1 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
| CHEMBL120632 | 211064 | None | 28 | Rat | Functional | pEC50 | = | 8.9 | 8.9 | 1 | 3 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm0000416 | |||||
| 10372489 | 4264 | None | 0 | Rat | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 692 | 20 | 7 | 7 | 1.3 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)O | 10.1021/jm0000416 | |||
| CHEMBL100538 | 4264 | None | 0 | Rat | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 692 | 20 | 7 | 7 | 1.3 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)O | 10.1021/jm0000416 | |||
| CHEMBL333477 | 213851 | None | 0 | Rat | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm0000416 | |||||
| 24861113 | 188296 | None | 0 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | -24 | 2 | ChEMBL | 564 | 7 | 1 | 6 | 5.9 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
| CHEMBL498942 | 188296 | None | 0 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | -24 | 2 | ChEMBL | 564 | 7 | 1 | 6 | 5.9 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
| CHEMBL506201 | 188296 | None | 0 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | -24 | 2 | ChEMBL | 564 | 7 | 1 | 6 | 5.9 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
| CHEMBL333477 | 213851 | None | 0 | Rat | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm9603072 | |||||
| CHEMBL414345 | 215584 | None | 4 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm0498755 | |||||
| 155535579 | 172153 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -158 | 2 | ChEMBL | 1836 | 71 | 17 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4471871 | 172153 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -158 | 2 | ChEMBL | 1836 | 71 | 17 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 10794634 | 113165 | None | 0 | Rat | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 677 | 19 | 7 | 7 | 0.3 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(N)=O | 10.1021/jm0000416 | |||
| CHEMBL331394 | 113165 | None | 0 | Rat | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 677 | 19 | 7 | 7 | 0.3 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(N)=O | 10.1021/jm0000416 | |||
| 162673242 | 183314 | None | 0 | Rat | Functional | pEC50 | = | 8.8 | 8.8 | 2 | 2 | ChEMBL | 1475 | 37 | 14 | 19 | -1.1 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/acs.jmedchem.0c01233 | |||
| CHEMBL4795913 | 183314 | None | 0 | Rat | Functional | pEC50 | = | 8.8 | 8.8 | 2 | 2 | ChEMBL | 1475 | 37 | 14 | 19 | -1.1 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/acs.jmedchem.0c01233 | |||
| 155560670 | 175196 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -72 | 2 | ChEMBL | 1886 | 72 | 17 | 23 | 4.2 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4568746 | 175196 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -72 | 2 | ChEMBL | 1886 | 72 | 17 | 23 | 4.2 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 162657745 | 181122 | None | 0 | Rat | Functional | pEC50 | = | 8.7 | 8.7 | 1 | 2 | ChEMBL | 1475 | 37 | 14 | 19 | -1.1 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/acs.jmedchem.0c01233 | |||
| CHEMBL4759105 | 181122 | None | 0 | Rat | Functional | pEC50 | = | 8.7 | 8.7 | 1 | 2 | ChEMBL | 1475 | 37 | 14 | 19 | -1.1 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/acs.jmedchem.0c01233 | |||
| 52949124 | 876 | None | 4 | Human | Functional | pEC50 | = | 6 | 6.0 | -2 | 3 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| 9055 | 876 | None | 4 | Human | Functional | pEC50 | = | 6 | 6.0 | -2 | 3 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| CHEMBL1269258 | 876 | None | 4 | Human | Functional | pEC50 | = | 6 | 6.0 | -2 | 3 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| DB12694 | 876 | None | 4 | Human | Functional | pEC50 | = | 6 | 6.0 | -2 | 3 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| 155539345 | 172936 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -3235 | 2 | ChEMBL | 1850 | 72 | 16 | 23 | 3.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4514283 | 172936 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -3235 | 2 | ChEMBL | 1850 | 72 | 16 | 23 | 3.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL382051 | 214753 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -109 | 5 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | |||||
| CHEMBL382051 | 214753 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -109 | 5 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | |||||
| 44580899 | 189184 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 1001 | 19 | 8 | 14 | 1.1 | CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm800174p | |||
| CHEMBL509792 | 189184 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 1001 | 19 | 8 | 14 | 1.1 | CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm800174p | |||
| CHEMBL414592 | 215605 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -8 | 2 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)N(C)C(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00093a013 | |||||
| 162673242 | 183314 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -2 | 2 | ChEMBL | 1475 | 37 | 14 | 19 | -1.1 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/acs.jmedchem.0c01233 | |||
| CHEMBL4795913 | 183314 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -2 | 2 | ChEMBL | 1475 | 37 | 14 | 19 | -1.1 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/acs.jmedchem.0c01233 | |||
| 162658676 | 181088 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -3 | 2 | ChEMBL | 1489 | 37 | 14 | 19 | -0.7 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/acs.jmedchem.0c01233 | |||
| CHEMBL4758706 | 181088 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -3 | 2 | ChEMBL | 1489 | 37 | 14 | 19 | -0.7 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/acs.jmedchem.0c01233 | |||
| 155566319 | 175844 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -4677 | 2 | ChEMBL | 1850 | 71 | 16 | 23 | 3.2 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4583158 | 175844 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -4677 | 2 | ChEMBL | 1850 | 71 | 16 | 23 | 3.2 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL64605 | 218346 | None | 5 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -3 | 4 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.0c00530 | |||||
| CHEMBL409529 | 215227 | None | 2 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -11 | 2 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00093a013 | |||||
| 155555065 | 174438 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -4168 | 2 | ChEMBL | 1836 | 71 | 17 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4550876 | 174438 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -4168 | 2 | ChEMBL | 1836 | 71 | 17 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 162657745 | 181122 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -1 | 2 | ChEMBL | 1475 | 37 | 14 | 19 | -1.1 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/acs.jmedchem.0c01233 | |||
| CHEMBL4759105 | 181122 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -1 | 2 | ChEMBL | 1475 | 37 | 14 | 19 | -1.1 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/acs.jmedchem.0c01233 | |||
| CHEMBL266839 | 213163 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -7 | 2 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00093a013 | |||||
| CHEMBL218763 | 211858 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -2 | 5 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
| 162666759 | 182426 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 17 | 2 | ChEMBL | 846 | 23 | 9 | 9 | 2.9 | CC(C)C[C@@H](/C=C/NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)OC(C)(C)C | 10.1021/acs.jmedchem.0c00530 | |||
| CHEMBL4784305 | 182426 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 17 | 2 | ChEMBL | 846 | 23 | 9 | 9 | 2.9 | CC(C)C[C@@H](/C=C/NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)OC(C)(C)C | 10.1021/acs.jmedchem.0c00530 | |||
| 155562281 | 175945 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -4168 | 2 | ChEMBL | 1900 | 71 | 16 | 23 | 4.4 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4585323 | 175945 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -4168 | 2 | ChEMBL | 1900 | 71 | 16 | 23 | 4.4 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 44418923 | 161879 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -5 | 5 | ChEMBL | 1132 | 28 | 13 | 13 | 1.7 | CCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2[nH]1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
| CHEMBL414087 | 161879 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -5 | 5 | ChEMBL | 1132 | 28 | 13 | 13 | 1.7 | CCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2[nH]1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
| CHEMBL218763 | 211858 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -2 | 5 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
| 155517761 | 170326 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -416 | 2 | ChEMBL | 1900 | 71 | 16 | 23 | 4.4 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4445529 | 170326 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -416 | 2 | ChEMBL | 1900 | 71 | 16 | 23 | 4.4 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 44346355 | 157959 | None | 0 | Rat | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 1260 | 26 | 13 | 15 | 1.7 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm0000416 | |||
| CHEMBL408389 | 157959 | None | 0 | Rat | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 1260 | 26 | 13 | 15 | 1.7 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm0000416 | |||
| 155543163 | 173390 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -8709 | 2 | ChEMBL | 1886 | 72 | 16 | 25 | 2.5 | CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4525615 | 173390 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -8709 | 2 | ChEMBL | 1886 | 72 | 16 | 25 | 2.5 | CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL408330 | 215165 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
| CHEMBL217609 | 211838 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -6 | 2 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00093a013 | |||||
| CHEMBL408330 | 215165 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
| CHEMBL208479 | 211658 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -33 | 5 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | |||||
| CHEMBL208479 | 211658 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -33 | 5 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | |||||
| 10509945 | 89418 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -63 | 2 | ChEMBL | 896 | 26 | 9 | 9 | 2.1 | CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL2369816 | 89418 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -63 | 2 | ChEMBL | 896 | 26 | 9 | 9 | 2.1 | CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL407057 | 215095 | None | 1 | Human | Functional | pEC50 | = | 4.7 | 4.7 | -1 | 5 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O | 10.1021/jm050921q | |||||
| 10628422 | 109229 | None | 0 | Rat | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 692 | 19 | 6 | 8 | 0.9 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(=O)OC | 10.1021/jm0000416 | |||
| CHEMBL321456 | 109229 | None | 0 | Rat | Functional | pEC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 692 | 19 | 6 | 8 | 0.9 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(=O)OC | 10.1021/jm0000416 | |||
| 44578767 | 173620 | None | 0 | Mouse | Functional | pEC50 | = | 8.7 | 8.7 | -3 | 2 | ChEMBL | 517 | 6 | 0 | 6 | 5.8 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
| CHEMBL453083 | 173620 | None | 0 | Mouse | Functional | pEC50 | = | 8.7 | 8.7 | -3 | 2 | ChEMBL | 517 | 6 | 0 | 6 | 5.8 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
| CHEMBL503822 | 173620 | None | 0 | Mouse | Functional | pEC50 | = | 8.7 | 8.7 | -3 | 2 | ChEMBL | 517 | 6 | 0 | 6 | 5.8 | CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 | 10.1016/j.bmcl.2008.06.057 | |||
| 1647 | 1313 | None | 34 | Human | Functional | pEC50 | = | 8.6 | 8.6 | 3 | 9 | ChEMBL | None | None | None | None | 10.1021/jm800174p | |||||
| 5462471 | 1313 | None | 34 | Human | Functional | pEC50 | = | 8.6 | 8.6 | 3 | 9 | ChEMBL | None | None | None | None | 10.1021/jm800174p | |||||
| CHEMBL113995 | 1313 | None | 34 | Human | Functional | pEC50 | = | 8.6 | 8.6 | 3 | 9 | ChEMBL | None | None | None | None | 10.1021/jm800174p | |||||
| CHEMBL38874 | 1313 | None | 34 | Human | Functional | pEC50 | = | 8.6 | 8.6 | 3 | 9 | ChEMBL | None | None | None | None | 10.1021/jm800174p | |||||
| 155568312 | 176182 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -36 | 2 | ChEMBL | 1836 | 72 | 17 | 23 | 3.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4591101 | 176182 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -36 | 2 | ChEMBL | 1836 | 72 | 17 | 23 | 3.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL218327 | 211853 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | 2 | 5 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
| 9853654 | 22797 | None | 34 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -9 | 4 | ChEMBL | 767 | 20 | 8 | 9 | 1.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.0c01233 | |||
| CHEMBL1328 | 22797 | None | 34 | Human | Functional | pEC50 | = | 8.6 | 8.6 | -9 | 4 | ChEMBL | 767 | 20 | 8 | 9 | 1.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.0c01233 | |||
| CHEMBL218327 | 211853 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | 2 | 5 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
| 44396746 | 127128 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -16 | 2 | ChEMBL | 637 | 8 | 2 | 6 | 5.7 | C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 | 10.1021/jm0498755 | |||
| CHEMBL365620 | 127128 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -16 | 2 | ChEMBL | 637 | 8 | 2 | 6 | 5.7 | C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 | 10.1021/jm0498755 | |||
| 155540394 | 173039 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -58 | 2 | ChEMBL | 1820 | 69 | 17 | 23 | 2.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4516794 | 173039 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -58 | 2 | ChEMBL | 1820 | 69 | 17 | 23 | 2.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 4627 | 822 | None | 42 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -1 | 6 | ChEMBL | None | None | None | None | 10.1021/jm050921q | |||||
| 864 | 822 | None | 42 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -1 | 6 | ChEMBL | None | None | None | None | 10.1021/jm050921q | |||||
| 9833444 | 822 | None | 42 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -1 | 6 | ChEMBL | None | None | None | None | 10.1021/jm050921q | |||||
| CHEMBL1121 | 822 | None | 42 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -1 | 6 | ChEMBL | None | None | None | None | 10.1021/jm050921q | |||||
| DB09142 | 822 | None | 42 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -1 | 6 | ChEMBL | None | None | None | None | 10.1021/jm050921q | |||||
| CHEMBL269185 | 213239 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -5 | 2 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)NCC(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00093a013 | |||||
| CHEMBL375360 | 214678 | None | 3 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm061268p | |||||
| 4627 | 822 | None | 42 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -1 | 6 | ChEMBL | None | None | None | None | 10.1021/jm050921q | |||||
| 864 | 822 | None | 42 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -1 | 6 | ChEMBL | None | None | None | None | 10.1021/jm050921q | |||||
| 9833444 | 822 | None | 42 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -1 | 6 | ChEMBL | None | None | None | None | 10.1021/jm050921q | |||||
| CHEMBL1121 | 822 | None | 42 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -1 | 6 | ChEMBL | None | None | None | None | 10.1021/jm050921q | |||||
| DB09142 | 822 | None | 42 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -1 | 6 | ChEMBL | None | None | None | None | 10.1021/jm050921q | |||||
| 52949124 | 876 | None | 4 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -2 | 3 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| 9055 | 876 | None | 4 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -2 | 3 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| CHEMBL1269258 | 876 | None | 4 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -2 | 3 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| DB12694 | 876 | None | 4 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -2 | 3 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| 10723875 | 14948 | None | 0 | Rat | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 767 | 21 | 7 | 7 | 2.1 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(=O)NCc1ccccc1 | 10.1021/jm0000416 | |||
| CHEMBL120827 | 14948 | None | 0 | Rat | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 767 | 21 | 7 | 7 | 2.1 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(=O)NCc1ccccc1 | 10.1021/jm0000416 | |||
| CHEMBL411271 | 215335 | None | 0 | Rat | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm0000416 | |||||
| CHEMBL336381 | 214042 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 2 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
| 155540739 | 172610 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -3388 | 2 | ChEMBL | 1907 | 74 | 17 | 24 | 2.5 | CCCC[C@H](NC(=O)[C@H](Cc1cc2ccccc2[nH]1)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4483457 | 172610 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -3388 | 2 | ChEMBL | 1907 | 74 | 17 | 24 | 2.5 | CCCC[C@H](NC(=O)[C@H](Cc1cc2ccccc2[nH]1)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL336381 | 214042 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 2 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
| CHEMBL383458 | 214773 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -1 | 5 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | |||||
| CHEMBL383458 | 214773 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -1 | 5 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | |||||
| CHEMBL205965 | 211628 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 42 | 5 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
| CHEMBL205965 | 211628 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 42 | 5 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
| 73347063 | 89488 | None | 0 | Rat | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 674 | 11 | 7 | 6 | 2.4 | C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O | 10.1021/jm9603072 | |||
| CHEMBL2371221 | 89488 | None | 0 | Rat | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 674 | 11 | 7 | 6 | 2.4 | C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O | 10.1021/jm9603072 | |||
| CHEMBL382349 | 214762 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 14 | 5 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
| 44418924 | 156974 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -8 | 5 | ChEMBL | 1031 | 27 | 13 | 12 | 0.2 | CCCC[C@H](NC(=O)[C@H](N)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
| CHEMBL407198 | 156974 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -8 | 5 | ChEMBL | 1031 | 27 | 13 | 12 | 0.2 | CCCC[C@H](NC(=O)[C@H](N)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
| CHEMBL382349 | 214762 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 14 | 5 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
| 162672110 | 182966 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 39 | 2 | ChEMBL | 848 | 22 | 9 | 9 | 2.0 | CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.0c00530 | |||
| CHEMBL4791620 | 182966 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 39 | 2 | ChEMBL | 848 | 22 | 9 | 9 | 2.0 | CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.0c00530 | |||
| 155535107 | 172117 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -323 | 2 | ChEMBL | 1904 | 73 | 19 | 22 | 4.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4471525 | 172117 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -323 | 2 | ChEMBL | 1904 | 73 | 19 | 22 | 4.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 155531277 | 171734 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -2 | 2 | ChEMBL | 1821 | 72 | 18 | 23 | 2.1 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4465747 | 171734 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -2 | 2 | ChEMBL | 1821 | 72 | 18 | 23 | 2.1 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 44396745 | 125105 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | -4 | 2 | ChEMBL | 623 | 8 | 2 | 6 | 5.5 | CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC4C5CC6CC(C5)CC4C6)CCCN3C2=O)cc1 | 10.1021/jm0498755 | |||
| CHEMBL364334 | 125105 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | -4 | 2 | ChEMBL | 623 | 8 | 2 | 6 | 5.5 | CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC4C5CC6CC(C5)CC4C6)CCCN3C2=O)cc1 | 10.1021/jm0498755 | |||
| CHEMBL2370248 | 212273 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | 1 | 2 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00093a013 | |||||
| 44580932 | 173574 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 617 | 14 | 6 | 10 | -1.5 | CNC(=O)COCC(=O)NCCCCNC(=O)COCC(=O)N[C@H]1CC[C@@]2(O)[C@H]3Cc4cc(O)cc5c4[C@@]2(CCN3C)[C@H]1O5 | 10.1021/jm800174p | |||
| CHEMBL452991 | 173574 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 617 | 14 | 6 | 10 | -1.5 | CNC(=O)COCC(=O)NCCCCNC(=O)COCC(=O)N[C@H]1CC[C@@]2(O)[C@H]3Cc4cc(O)cc5c4[C@@]2(CCN3C)[C@H]1O5 | 10.1021/jm800174p | |||
| 52949124 | 876 | None | 4 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -2 | 3 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| 9055 | 876 | None | 4 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -2 | 3 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| CHEMBL1269258 | 876 | None | 4 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -2 | 3 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| DB12694 | 876 | None | 4 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -2 | 3 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| CHEMBL386682 | 214847 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -60 | 2 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN(C)C(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00093a013 | |||||
| CHEMBL206974 | 211641 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | 2 | 5 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
| CHEMBL206974 | 211641 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | 2 | 5 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
| 44387568 | 62227 | None | 0 | Rat | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 660 | 11 | 7 | 6 | 2.0 | C[C@@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O | 10.1021/jm0000416 | |||
| CHEMBL177799 | 62227 | None | 0 | Rat | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 660 | 11 | 7 | 6 | 2.0 | C[C@@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O | 10.1021/jm0000416 | |||
| 10327028 | 89489 | None | 0 | Rat | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 660 | 11 | 7 | 6 | 2.0 | C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O | 10.1021/jm9603072 | |||
| CHEMBL2371222 | 89489 | None | 0 | Rat | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 660 | 11 | 7 | 6 | 2.0 | C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O | 10.1021/jm9603072 | |||
| 10439779 | 106742 | None | 0 | Rat | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 710 | 11 | 7 | 8 | 2.2 | C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCSSCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O | 10.1021/jm9603072 | |||
| CHEMBL3143501 | 106742 | None | 0 | Rat | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 710 | 11 | 7 | 8 | 2.2 | C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCSSCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O | 10.1021/jm9603072 | |||
| CHEMBL262172 | 212987 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -19 | 5 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | |||||
| CHEMBL262172 | 212987 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -19 | 5 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | |||||
| 155535249 | 172106 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | -2754 | 2 | ChEMBL | 1808 | 68 | 16 | 23 | 2.0 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4471373 | 172106 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | -2754 | 2 | ChEMBL | 1808 | 68 | 16 | 23 | 2.0 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 155515427 | 170052 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -1819 | 2 | ChEMBL | 1886 | 72 | 17 | 23 | 4.2 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4441596 | 170052 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -1819 | 2 | ChEMBL | 1886 | 72 | 17 | 23 | 4.2 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL217236 | 211831 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -4 | 2 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00093a013 | |||||
| 52949124 | 876 | None | 4 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -2 | 3 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| 9055 | 876 | None | 4 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -2 | 3 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| CHEMBL1269258 | 876 | None | 4 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -2 | 3 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| DB12694 | 876 | None | 4 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -2 | 3 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| 44396655 | 122116 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | 3 | 2 | ChEMBL | 608 | 8 | 2 | 5 | 5.7 | C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 | 10.1021/jm0498755 | |||
| CHEMBL359589 | 122116 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | 3 | 2 | ChEMBL | 608 | 8 | 2 | 5 | 5.7 | C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 | 10.1021/jm0498755 | |||
| 45113249 | 5491 | None | 0 | Human | Functional | pED50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 1259 | 33 | 13 | 12 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)CCNC(=S)Nc1ccc(O)c(NC(=O)CNC(=O)CSC(c2ccccc2)(c2ccccc2)c2ccccc2)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.ejmech.2009.09.043 | |||
| CHEMBL1076229 | 5491 | None | 0 | Human | Functional | pED50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 1259 | 33 | 13 | 12 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)CCNC(=S)Nc1ccc(O)c(NC(=O)CNC(=O)CSC(c2ccccc2)(c2ccccc2)c2ccccc2)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.ejmech.2009.09.043 | |||
| 45113375 | 5493 | None | 0 | Human | Functional | pED50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1344 | 39 | 13 | 12 | 7.8 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)CCCCCNC(=S)Nc1ccc(O)c(NC(=O)CNC(=O)CSC(c2ccccc2)(c2ccccc2)c2ccccc2)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.ejmech.2009.09.043 | |||
| CHEMBL1076232 | 5493 | None | 0 | Human | Functional | pED50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 1344 | 39 | 13 | 12 | 7.8 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)CCCCCNC(=S)Nc1ccc(O)c(NC(=O)CNC(=O)CSC(c2ccccc2)(c2ccccc2)c2ccccc2)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.ejmech.2009.09.043 | |||
| 46879513 | 5492 | None | 0 | Human | Functional | pED50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 1118 | 27 | 11 | 10 | 7.0 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=S)Nc1ccc(O)c(NC(=O)CNC(=O)CSC(c2ccccc2)(c2ccccc2)c2ccccc2)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.ejmech.2009.09.043 | |||
| CHEMBL1076230 | 5492 | None | 0 | Human | Functional | pED50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 1118 | 27 | 11 | 10 | 7.0 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=S)Nc1ccc(O)c(NC(=O)CNC(=O)CSC(c2ccccc2)(c2ccccc2)c2ccccc2)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.ejmech.2009.09.043 | |||
| 70697518 | 77835 | None | 0 | Human | Functional | pIC50 | = | 4 | 4.0 | -1 | 2 | ChEMBL | 367 | 3 | 2 | 3 | 4.4 | O=C1Nc2ccccc2C(c2ccccc2)=NC1C[C@@H]1CNc2ccccc21 | 10.1021/jm00390a019 | |||
| CHEMBL2092748 | 77835 | None | 0 | Human | Functional | pIC50 | = | 4 | 4.0 | -1 | 2 | ChEMBL | 367 | 3 | 2 | 3 | 4.4 | O=C1Nc2ccccc2C(c2ccccc2)=NC1C[C@@H]1CNc2ccccc21 | 10.1021/jm00390a019 | |||
| 44281084 | 112755 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 497 | 8 | 3 | 4 | 3.3 | O=C(O)CNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL33043 | 112755 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 497 | 8 | 3 | 4 | 3.3 | O=C(O)CNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 44280368 | 96950 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 573 | 8 | 2 | 4 | 5.4 | CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccc(C(=O)O)cc1 | 10.1021/jm950372w | |||
| CHEMBL265740 | 96950 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 573 | 8 | 2 | 4 | 5.4 | CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccc(C(=O)O)cc1 | 10.1021/jm950372w | |||
| 44280992 | 100173 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 678 | 12 | 4 | 5 | 5.5 | CC1(C)CCC(NC(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL287564 | 100173 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 678 | 12 | 4 | 5 | 5.5 | CC1(C)CCC(NC(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 | 10.1021/jm950372w | |||
| 44280620 | 103971 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 686 | 15 | 4 | 5 | 5.2 | O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCCc1ccccc1 | 10.1021/jm950372w | |||
| CHEMBL30924 | 103971 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 686 | 15 | 4 | 5 | 5.2 | O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCCc1ccccc1 | 10.1021/jm950372w | |||
| 44280113 | 168333 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 684 | 12 | 4 | 5 | 5.5 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1ccc2c(c1)CCC2 | 10.1021/jm950372w | |||
| CHEMBL433623 | 168333 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 684 | 12 | 4 | 5 | 5.5 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1ccc2c(c1)CCC2 | 10.1021/jm950372w | |||
| 44280895 | 168199 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 652 | 15 | 3 | 5 | 5.1 | CCCN(CCC)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL432679 | 168199 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 652 | 15 | 3 | 5 | 5.1 | CCCN(CCC)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 44212546 | 99982 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 626 | 10 | 4 | 4 | 5.3 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL286228 | 99982 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 626 | 10 | 4 | 4 | 5.3 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm950372w | |||
| 44280314 | 169797 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 694 | 12 | 4 | 5 | 6.2 | O=C(CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)Nc1cccc2ccccc12 | 10.1021/jm950372w | |||
| CHEMBL443781 | 169797 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 694 | 12 | 4 | 5 | 6.2 | O=C(CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)Nc1cccc2ccccc12 | 10.1021/jm950372w | |||
| 13822916 | 189835 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | -39 | 3 | ChEMBL | 421 | 3 | 1 | 4 | 5.3 | Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=N[C@@H]2Cc1c[nH]c2ccccc12 | 10.1021/jm00390a019 | |||
| CHEMBL51569 | 189835 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | -39 | 3 | ChEMBL | 421 | 3 | 1 | 4 | 5.3 | Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=N[C@@H]2Cc1c[nH]c2ccccc12 | 10.1021/jm00390a019 | |||
| 65987 | 99631 | None | 12 | Human | Functional | pIC50 | = | 5.9 | 5.9 | 10 | 2 | ChEMBL | 440 | 6 | 2 | 3 | 4.1 | O=C(O)CC[C@@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL283820 | 99631 | None | 12 | Human | Functional | pIC50 | = | 5.9 | 5.9 | 10 | 2 | ChEMBL | 440 | 6 | 2 | 3 | 4.1 | O=C(O)CC[C@@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 44280179 | 103076 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 601 | 11 | 3 | 4 | 5.3 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(CCc1ccccc1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL30696 | 103076 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 601 | 11 | 3 | 4 | 5.3 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(CCc1ccccc1)C(=O)O | 10.1021/jm950372w | |||
| 44280090 | 99590 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 640 | 11 | 4 | 4 | 5.7 | O=C(O)CC(Cc1c[nH]c2ccccc12)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL283460 | 99590 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 640 | 11 | 4 | 4 | 5.7 | O=C(O)CC(Cc1c[nH]c2ccccc12)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 44280245 | 100089 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 708 | 12 | 3 | 5 | 6.2 | CN(C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1cccc2ccccc12 | 10.1021/jm950372w | |||
| CHEMBL286941 | 100089 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 708 | 12 | 3 | 5 | 6.2 | CN(C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1cccc2ccccc12 | 10.1021/jm950372w | |||
| 656755 | 67731 | None | 24 | Human | Functional | pIC50 | = | 4.9 | 4.9 | -1 | 2 | ChEMBL | 397 | 3 | 1 | 2 | 4.7 | CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
| CHEMBL1907717 | 67731 | None | 24 | Human | Functional | pIC50 | = | 4.9 | 4.9 | -1 | 2 | ChEMBL | 397 | 3 | 1 | 2 | 4.7 | CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
| 15167802 | 67733 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | 2 | 2 | ChEMBL | 436 | 5 | 1 | 3 | 5.0 | N#CCCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
| CHEMBL1907720 | 67733 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | 2 | 2 | ChEMBL | 436 | 5 | 1 | 3 | 5.0 | N#CCCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
| 15614841 | 67742 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | 6 | 2 | ChEMBL | 390 | 5 | 1 | 3 | 4.7 | O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@@H]1COCc1ccccc1 | 10.1021/jm00390a019 | |||
| CHEMBL1907734 | 67742 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | 6 | 2 | ChEMBL | 390 | 5 | 1 | 3 | 4.7 | O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@@H]1COCc1ccccc1 | 10.1021/jm00390a019 | |||
| 15614739 | 75447 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 350 | 3 | 1 | 3 | 4.3 | O=C1Nc2ccccc2C(c2ccccc2F)=NC1Cc1ccsc1 | 10.1021/jm00390a019 | |||
| CHEMBL20408 | 75447 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 350 | 3 | 1 | 3 | 4.3 | O=C1Nc2ccccc2C(c2ccccc2F)=NC1Cc1ccsc1 | 10.1021/jm00390a019 | |||
| 20063212 | 167237 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | 3 | 2 | ChEMBL | 395 | 3 | 0 | 3 | 4.5 | CN1CC(CC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c2ccccc21 | 10.1021/jm00390a019 | |||
| CHEMBL429063 | 167237 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | 3 | 2 | ChEMBL | 395 | 3 | 0 | 3 | 4.5 | CN1CC(CC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c2ccccc21 | 10.1021/jm00390a019 | |||
| 44279853 | 104849 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 593 | 10 | 3 | 4 | 5.6 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](CC1CCCCC1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL31093 | 104849 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 593 | 10 | 3 | 4 | 5.6 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](CC1CCCCC1)C(=O)O | 10.1021/jm950372w | |||
| 44418923 | 161879 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | -5 | 5 | ChEMBL | 1132 | 28 | 13 | 13 | 1.7 | CCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2[nH]1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
| CHEMBL414087 | 161879 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | -5 | 5 | ChEMBL | 1132 | 28 | 13 | 13 | 1.7 | CCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2[nH]1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
| 44280622 | 119278 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 698 | 12 | 4 | 5 | 5.9 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2c1CCCC2 | 10.1021/jm950372w | |||
| CHEMBL34332 | 119278 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 698 | 12 | 4 | 5 | 5.9 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2c1CCCC2 | 10.1021/jm950372w | |||
| 44280374 | 102922 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 559 | 8 | 3 | 4 | 5.4 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1cccc(C(=O)O)c1 | 10.1021/jm950372w | |||
| CHEMBL30575 | 102922 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 559 | 8 | 3 | 4 | 5.4 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1cccc(C(=O)O)c1 | 10.1021/jm950372w | |||
| 44280510 | 103010 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 621 | 10 | 3 | 4 | 5.5 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccc(Cl)cc1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL30639 | 103010 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 621 | 10 | 3 | 4 | 5.5 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccc(Cl)cc1)C(=O)O | 10.1021/jm950372w | |||
| 44280406 | 119590 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 658 | 12 | 3 | 5 | 5.1 | CN(C(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccccc1 | 10.1021/jm950372w | |||
| CHEMBL34569 | 119590 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 658 | 12 | 3 | 5 | 5.1 | CN(C(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccccc1 | 10.1021/jm950372w | |||
| 44280598 | 100547 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 694 | 12 | 4 | 5 | 6.2 | O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 | 10.1021/jm950372w | |||
| CHEMBL291001 | 100547 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 694 | 12 | 4 | 5 | 6.2 | O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 | 10.1021/jm950372w | |||
| 44280399 | 103150 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 603 | 10 | 4 | 5 | 4.6 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccc(O)cc1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL30756 | 103150 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 603 | 10 | 4 | 5 | 4.6 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccc(O)cc1)C(=O)O | 10.1021/jm950372w | |||
| 44396655 | 122116 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | 3 | 2 | ChEMBL | 608 | 8 | 2 | 5 | 5.7 | C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 | 10.1021/jm0498755 | |||
| CHEMBL359589 | 122116 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | 3 | 2 | ChEMBL | 608 | 8 | 2 | 5 | 5.7 | C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 | 10.1021/jm0498755 | |||
| 70697534 | 77876 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | 1 | 2 | ChEMBL | 367 | 3 | 2 | 3 | 4.4 | O=C1Nc2ccccc2C(c2ccccc2)=NC1C[C@H]1CNc2ccccc21 | 10.1021/jm00390a019 | |||
| CHEMBL2092989 | 77876 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | 1 | 2 | ChEMBL | 367 | 3 | 2 | 3 | 4.4 | O=C1Nc2ccccc2C(c2ccccc2)=NC1C[C@H]1CNc2ccccc21 | 10.1021/jm00390a019 | |||
| 44280131 | 99646 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 680 | 11 | 4 | 5 | 5.8 | O=C(O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 | 10.1021/jm950372w | |||
| CHEMBL283914 | 99646 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 680 | 11 | 4 | 5 | 5.8 | O=C(O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 | 10.1021/jm950372w | |||
| 44280177 | 99543 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 601 | 11 | 3 | 4 | 5.3 | O=C(O)C[C@H](Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL283204 | 99543 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 601 | 11 | 3 | 4 | 5.3 | O=C(O)C[C@H](Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 5311201 | 209854 | None | 26 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 1 | 7 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00067a001 | |||
| CHEMBL9387 | 209854 | None | 26 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 1 | 7 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00067a001 | |||
| 44280915 | 100333 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 676 | 10 | 3 | 5 | 5.2 | O=C(O)C[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL289008 | 100333 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 676 | 10 | 3 | 5 | 5.2 | O=C(O)C[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 44279852 | 99416 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 690 | 11 | 3 | 5 | 5.6 | O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL282476 | 99416 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 690 | 11 | 3 | 5 | 5.6 | O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 15167824 | 67740 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | -2 | 2 | ChEMBL | 379 | 3 | 1 | 2 | 4.6 | CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00390a019 | |||
| CHEMBL1907731 | 67740 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | -2 | 2 | ChEMBL | 379 | 3 | 1 | 2 | 4.6 | CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00390a019 | |||
| 44396746 | 127128 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | -16 | 2 | ChEMBL | 637 | 8 | 2 | 6 | 5.7 | C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 | 10.1021/jm0498755 | |||
| CHEMBL365620 | 127128 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | -16 | 2 | ChEMBL | 637 | 8 | 2 | 6 | 5.7 | C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 | 10.1021/jm0498755 | |||
| 44351469 | 116999 | None | 0 | Rat | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 603 | 7 | 3 | 4 | 6.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CC(c2ccc(Cl)cc2)C[C@@H]1C(=O)O | 10.1021/jm970439a | |||
| CHEMBL338526 | 116999 | None | 0 | Rat | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 603 | 7 | 3 | 4 | 6.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CC(c2ccc(Cl)cc2)C[C@@H]1C(=O)O | 10.1021/jm970439a | |||
| 44280316 | 96817 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 680 | 11 | 4 | 5 | 5.8 | O=C(C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)Nc1cccc2ccccc12 | 10.1021/jm950372w | |||
| CHEMBL264606 | 96817 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 680 | 11 | 4 | 5 | 5.8 | O=C(C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)Nc1cccc2ccccc12 | 10.1021/jm950372w | |||
| 15614824 | 67750 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 453 | 6 | 1 | 2 | 6.1 | CC(C)CCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
| CHEMBL1907743 | 67750 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 453 | 6 | 1 | 2 | 6.1 | CC(C)CCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
| 44280893 | 99290 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 652 | 13 | 4 | 5 | 5.0 | CC(C)(C)CCNC(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL281671 | 99290 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 652 | 13 | 4 | 5 | 5.0 | CC(C)(C)CCNC(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 44280193 | 103186 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 672 | 13 | 3 | 5 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL30784 | 103186 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 672 | 13 | 3 | 5 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 44279938 | 162720 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 637 | 10 | 3 | 4 | 6.0 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccc2ccccc2c1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL416944 | 162720 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 637 | 10 | 3 | 4 | 6.0 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccc2ccccc2c1)C(=O)O | 10.1021/jm950372w | |||
| 15167783 | 67743 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | -1 | 2 | ChEMBL | 409 | 4 | 3 | 3 | 4.3 | O=C(O)c1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)C(=O)Nc2ccccc21 | 10.1021/jm00390a019 | |||
| CHEMBL1907735 | 67743 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | -1 | 2 | ChEMBL | 409 | 4 | 3 | 3 | 4.3 | O=C(O)c1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)C(=O)Nc2ccccc21 | 10.1021/jm00390a019 | |||
| 44280110 | 102945 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 587 | 10 | 3 | 4 | 4.9 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL30592 | 102945 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 587 | 10 | 3 | 4 | 4.9 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm950372w | |||
| 44280112 | 99649 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 684 | 11 | 3 | 5 | 5.4 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCCc2ccccc21 | 10.1021/jm950372w | |||
| CHEMBL283924 | 99649 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 684 | 11 | 3 | 5 | 5.4 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCCc2ccccc21 | 10.1021/jm950372w | |||
| 15614830 | 67739 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 469 | 6 | 1 | 4 | 4.7 | CCOC(=O)CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
| CHEMBL1907730 | 67739 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 469 | 6 | 1 | 4 | 4.7 | CCOC(=O)CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
| 15614828 | 67741 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 454 | 6 | 1 | 3 | 4.7 | CN(C)CCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
| CHEMBL1907733 | 67741 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 454 | 6 | 1 | 3 | 4.7 | CN(C)CCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
| 44280130 | 161373 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 670 | 11 | 3 | 5 | 5.0 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCc2ccccc21 | 10.1021/jm950372w | |||
| CHEMBL412108 | 161373 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 670 | 11 | 3 | 5 | 5.0 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCc2ccccc21 | 10.1021/jm950372w | |||
| CHEMBL375360 | 214678 | None | 3 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm061268p | |||||
| 44280163 | 104428 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 658 | 12 | 3 | 5 | 4.7 | CN(Cc1ccccc1)C(=O)[C@H](CC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL31018 | 104428 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 658 | 12 | 3 | 5 | 4.7 | CN(Cc1ccccc1)C(=O)[C@H](CC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 44280974 | 100061 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 690 | 11 | 3 | 5 | 5.4 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2CCCCC2C1 | 10.1021/jm950372w | |||
| CHEMBL286763 | 100061 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 690 | 11 | 3 | 5 | 5.4 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2CCCCC2C1 | 10.1021/jm950372w | |||
| 15167770 | 67746 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 369 | 3 | 2 | 2 | 5.2 | Fc1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)CNc2ccccc21 | 10.1021/jm00390a019 | |||
| CHEMBL1907738 | 67746 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 369 | 3 | 2 | 2 | 5.2 | Fc1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)CNc2ccccc21 | 10.1021/jm00390a019 | |||
| 44280363 | 102395 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 511 | 8 | 2 | 4 | 3.6 | CN(CC(=O)O)C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL30369 | 102395 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 511 | 8 | 2 | 4 | 3.6 | CN(CC(=O)O)C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 108187 | 926 | None | 30 | Rat | Functional | pIC50 | = | 7.5 | 7.5 | -91 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm970439a | |||
| 873 | 926 | None | 30 | Rat | Functional | pIC50 | = | 7.5 | 7.5 | -91 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm970439a | |||
| CHEMBL2062154 | 926 | None | 30 | Rat | Functional | pIC50 | = | 7.5 | 7.5 | -91 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm970439a | |||
| CHEMBL287735 | 926 | None | 30 | Rat | Functional | pIC50 | = | 7.5 | 7.5 | -91 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm970439a | |||
| 9865694 | 206634 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | -8 | 2 | ChEMBL | 399 | 3 | 2 | 2 | 5.2 | O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@@H]1Cc1c[nH]c2ccccc12 | 10.1021/jm00390a019 | |||
| CHEMBL70728 | 206634 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | -8 | 2 | ChEMBL | 399 | 3 | 2 | 2 | 5.2 | O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@@H]1Cc1c[nH]c2ccccc12 | 10.1021/jm00390a019 | |||
| 44280509 | 99458 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 588 | 10 | 3 | 5 | 4.3 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccccn1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL282732 | 99458 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 588 | 10 | 3 | 5 | 4.3 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccccn1)C(=O)O | 10.1021/jm950372w | |||
| 44280178 | 102677 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 601 | 11 | 3 | 4 | 5.3 | O=C(O)C[C@@H](Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL30422 | 102677 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 601 | 11 | 3 | 4 | 5.3 | O=C(O)C[C@@H](Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 44280694 | 100334 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 571 | 11 | 3 | 5 | 4.4 | CSCCC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL289018 | 100334 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 571 | 11 | 3 | 5 | 4.4 | CSCCC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O | 10.1021/jm950372w | |||
| 44280246 | 102219 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 694 | 12 | 4 | 5 | 6.2 | O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1ccc2ccccc2c1 | 10.1021/jm950372w | |||
| CHEMBL30262 | 102219 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 694 | 12 | 4 | 5 | 6.2 | O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1ccc2ccccc2c1 | 10.1021/jm950372w | |||
| 44280123 | 99327 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 626 | 10 | 4 | 4 | 5.3 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL281903 | 99327 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 626 | 10 | 4 | 4 | 5.3 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm950372w | |||
| 44280397 | 103731 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 587 | 10 | 3 | 4 | 4.9 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccccc1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL30875 | 103731 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 587 | 10 | 3 | 4 | 4.9 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccccc1)C(=O)O | 10.1021/jm950372w | |||
| 44280233 | 99262 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 672 | 13 | 3 | 5 | 5.1 | CN(Cc1ccccc1)C(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL281490 | 99262 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 672 | 13 | 3 | 5 | 5.1 | CN(Cc1ccccc1)C(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 44279937 | 104918 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 690 | 11 | 3 | 5 | 5.6 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL31101 | 104918 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 690 | 11 | 3 | 5 | 5.6 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 44351445 | 116998 | None | 0 | Rat | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 654 | 8 | 3 | 6 | 5.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O | 10.1021/jm970439a | |||
| CHEMBL338525 | 116998 | None | 0 | Rat | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 654 | 8 | 3 | 6 | 5.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O | 10.1021/jm970439a | |||
| 44280234 | 102340 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 658 | 13 | 4 | 5 | 4.7 | O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCc1ccccc1 | 10.1021/jm950372w | |||
| CHEMBL30335 | 102340 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 658 | 13 | 4 | 5 | 4.7 | O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCc1ccccc1 | 10.1021/jm950372w | |||
| 15556550 | 67744 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | 1 | 2 | ChEMBL | 326 | 3 | 1 | 2 | 4.5 | CC(C)C[C@H]1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O | 10.1021/jm00390a019 | |||
| CHEMBL1907736 | 67744 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | 1 | 2 | ChEMBL | 326 | 3 | 1 | 2 | 4.5 | CC(C)C[C@H]1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O | 10.1021/jm00390a019 | |||
| 44351444 | 116950 | None | 0 | Rat | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 622 | 8 | 3 | 6 | 4.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O | 10.1021/jm970439a | |||
| CHEMBL338300 | 116950 | None | 0 | Rat | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 622 | 8 | 3 | 6 | 4.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O | 10.1021/jm970439a | |||
| 5311201 | 209854 | None | 26 | Rat | Functional | pIC50 | = | 7.4 | 7.4 | -7 | 7 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm970439a | |||
| CHEMBL9387 | 209854 | None | 26 | Rat | Functional | pIC50 | = | 7.4 | 7.4 | -7 | 7 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm970439a | |||
| 44280502 | 99440 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 672 | 14 | 4 | 5 | 4.8 | O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCc1ccccc1 | 10.1021/jm950372w | |||
| CHEMBL282639 | 99440 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 672 | 14 | 4 | 5 | 4.8 | O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCc1ccccc1 | 10.1021/jm950372w | |||
| 44418924 | 156974 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -8 | 5 | ChEMBL | 1031 | 27 | 13 | 12 | 0.2 | CCCC[C@H](NC(=O)[C@H](N)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
| CHEMBL407198 | 156974 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -8 | 5 | ChEMBL | 1031 | 27 | 13 | 12 | 0.2 | CCCC[C@H](NC(=O)[C@H](N)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
| 9800177 | 67730 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | 1 | 2 | ChEMBL | 383 | 3 | 2 | 2 | 4.7 | O=C1Nc2ccccc2C(c2ccccc2F)=N[C@@H]1Cc1c[nH]c2ccccc12 | 10.1021/jm00390a019 | |||
| CHEMBL1907714 | 67730 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | 1 | 2 | ChEMBL | 383 | 3 | 2 | 2 | 4.7 | O=C1Nc2ccccc2C(c2ccccc2F)=N[C@@H]1Cc1c[nH]c2ccccc12 | 10.1021/jm00390a019 | |||
| 44280350 | 99906 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 658 | 12 | 3 | 5 | 4.7 | CN(Cc1ccccc1)C(=O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL285739 | 99906 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 658 | 12 | 3 | 5 | 4.7 | CN(Cc1ccccc1)C(=O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O | 10.1021/jm950372w | |||
| 44396745 | 125105 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -4 | 2 | ChEMBL | 623 | 8 | 2 | 6 | 5.5 | CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC4C5CC6CC(C5)CC4C6)CCCN3C2=O)cc1 | 10.1021/jm0498755 | |||
| CHEMBL364334 | 125105 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -4 | 2 | ChEMBL | 623 | 8 | 2 | 6 | 5.5 | CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC4C5CC6CC(C5)CC4C6)CCCN3C2=O)cc1 | 10.1021/jm0498755 | |||
| 44280894 | 113574 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 708 | 19 | 3 | 5 | 6.6 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL33209 | 113574 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 708 | 19 | 3 | 5 | 6.6 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 44280381 | 102999 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 511 | 9 | 3 | 4 | 3.6 | O=C(O)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL30634 | 102999 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 511 | 9 | 3 | 4 | 3.6 | O=C(O)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 44280111 | 100023 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 684 | 11 | 3 | 5 | 5.0 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCc2ccccc2C1 | 10.1021/jm950372w | |||
| CHEMBL286510 | 100023 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 684 | 11 | 3 | 5 | 5.0 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCc2ccccc2C1 | 10.1021/jm950372w | |||
| 15614734 | 67738 | None | 1 | Human | Functional | pIC50 | = | 4.3 | 4.3 | -2 | 2 | ChEMBL | 411 | 3 | 0 | 3 | 4.7 | CN1C(=O)[C@@H](Cc2cn(C)c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
| CHEMBL1907729 | 67738 | None | 1 | Human | Functional | pIC50 | = | 4.3 | 4.3 | -2 | 2 | ChEMBL | 411 | 3 | 0 | 3 | 4.7 | CN1C(=O)[C@@H](Cc2cn(C)c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
| 15167776 | 67737 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | 4 | 2 | ChEMBL | 441 | 5 | 2 | 3 | 4.2 | O=C(O)CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
| CHEMBL1907728 | 67737 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | 4 | 2 | ChEMBL | 441 | 5 | 2 | 3 | 4.2 | O=C(O)CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
| 14444002 | 121118 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 635 | 15 | 6 | 6 | 3.8 | CC(C)CC(CC(=O)NC(CC(=O)O)C(=O)NCc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm00123a003 | |||
| CHEMBL356844 | 121118 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 635 | 15 | 6 | 6 | 3.8 | CC(C)CC(CC(=O)NC(CC(=O)O)C(=O)NCc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm00123a003 | |||
| 15614807 | 67748 | None | 1 | Human | Functional | pIC50 | = | 4.3 | 4.3 | 1 | 2 | ChEMBL | 365 | 3 | 2 | 2 | 4.6 | O=C1Nc2ccccc2C(c2ccccc2)=N[C@@H]1Cc1c[nH]c2ccccc12 | 10.1021/jm00390a019 | |||
| CHEMBL1907740 | 67748 | None | 1 | Human | Functional | pIC50 | = | 4.3 | 4.3 | 1 | 2 | ChEMBL | 365 | 3 | 2 | 2 | 4.6 | O=C1Nc2ccccc2C(c2ccccc2)=N[C@@H]1Cc1c[nH]c2ccccc12 | 10.1021/jm00390a019 | |||
| 44351446 | 156232 | None | 0 | Rat | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 631 | 9 | 3 | 8 | 4.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O | 10.1021/jm970439a | |||
| CHEMBL406359 | 156232 | None | 0 | Rat | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 631 | 9 | 3 | 8 | 4.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O | 10.1021/jm970439a | |||
| 44279957 | 99265 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 553 | 10 | 3 | 4 | 4.7 | CC(C)CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL281507 | 99265 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 553 | 10 | 3 | 4 | 4.7 | CC(C)CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O | 10.1021/jm950372w | |||
| 44280091 | 168541 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 640 | 10 | 3 | 4 | 5.7 | CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL434967 | 168541 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 640 | 10 | 3 | 4 | 5.7 | CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm950372w | |||
| 44280244 | 13231 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 695 | 12 | 4 | 6 | 5.6 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2cccnc12 | 10.1021/jm950372w | |||
| CHEMBL1191257 | 13231 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 695 | 12 | 4 | 6 | 5.6 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2cccnc12 | 10.1021/jm950372w | |||
| CHEMBL542330 | 13231 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 695 | 12 | 4 | 6 | 5.6 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2cccnc12 | 10.1021/jm950372w | |||
| 44280103 | 168061 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 573 | 8 | 2 | 4 | 5.4 | CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccccc1C(=O)O | 10.1021/jm950372w | |||
| CHEMBL431692 | 168061 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 573 | 8 | 2 | 4 | 5.4 | CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccccc1C(=O)O | 10.1021/jm950372w | |||
| 44280315 | 101674 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 672 | 13 | 3 | 5 | 5.1 | CN(Cc1ccccc1)C(=O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL29891 | 101674 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 672 | 13 | 3 | 5 | 5.1 | CN(Cc1ccccc1)C(=O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O | 10.1021/jm950372w | |||
| 44280102 | 102764 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 587 | 10 | 3 | 4 | 4.9 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccccc1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL30481 | 102764 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 587 | 10 | 3 | 4 | 4.9 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccccc1)C(=O)O | 10.1021/jm950372w | |||
| 44280387 | 119832 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 559 | 8 | 3 | 4 | 5.4 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1ccccc1C(=O)O | 10.1021/jm950372w | |||
| CHEMBL34797 | 119832 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 559 | 8 | 3 | 4 | 5.4 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1ccccc1C(=O)O | 10.1021/jm950372w | |||
| 44351455 | 116883 | None | 0 | Rat | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 604 | 8 | 3 | 6 | 4.6 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2)C[C@@H]1C(=O)O | 10.1021/jm970439a | |||
| CHEMBL337934 | 116883 | None | 0 | Rat | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 604 | 8 | 3 | 6 | 4.6 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2)C[C@@H]1C(=O)O | 10.1021/jm970439a | |||
| 44351454 | 116882 | None | 0 | Rat | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 712 | 8 | 3 | 6 | 5.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(I)cc2)C[C@@H]1C(=O)O | 10.1021/jm970439a | |||
| CHEMBL337933 | 116882 | None | 0 | Rat | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 712 | 8 | 3 | 6 | 5.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(I)cc2)C[C@@H]1C(=O)O | 10.1021/jm970439a | |||
| 44280375 | 99162 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 559 | 8 | 3 | 4 | 5.4 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1ccc(C(=O)O)cc1 | 10.1021/jm950372w | |||
| CHEMBL280832 | 99162 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 559 | 8 | 3 | 4 | 5.4 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1ccc(C(=O)O)cc1 | 10.1021/jm950372w | |||
| 44280621 | 103980 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 658 | 13 | 4 | 5 | 4.4 | O=C(O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCc1ccccc1 | 10.1021/jm950372w | |||
| CHEMBL30926 | 103980 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 658 | 13 | 4 | 5 | 4.4 | O=C(O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCc1ccccc1 | 10.1021/jm950372w | |||
| 15167804 | 67732 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | 1 | 2 | ChEMBL | 455 | 6 | 2 | 3 | 4.6 | O=C(O)CCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
| CHEMBL1907719 | 67732 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | 1 | 2 | ChEMBL | 455 | 6 | 2 | 3 | 4.6 | O=C(O)CCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00390a019 | |||
| 15614820 | 67745 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | -1 | 2 | ChEMBL | 437 | 5 | 1 | 2 | 5.5 | O=C1[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc2N1CC1CC1 | 10.1021/jm00390a019 | |||
| CHEMBL1907737 | 67745 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | -1 | 2 | ChEMBL | 437 | 5 | 1 | 2 | 5.5 | O=C1[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc2N1CC1CC1 | 10.1021/jm00390a019 | |||
| 44280000 | 103308 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 525 | 10 | 3 | 4 | 4.0 | O=C(O)CCCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL30844 | 103308 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 525 | 10 | 3 | 4 | 4.0 | O=C(O)CCCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 15167820 | 67735 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | -1 | 2 | ChEMBL | 393 | 3 | 0 | 3 | 4.6 | CN1C(=O)[C@@H](Cc2cn(C)c3ccccc23)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00390a019 | |||
| CHEMBL1907724 | 67735 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | -1 | 2 | ChEMBL | 393 | 3 | 0 | 3 | 4.6 | CN1C(=O)[C@@H](Cc2cn(C)c3ccccc23)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00390a019 | |||
| 44280599 | 99216 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 630 | 2 | ChEMBL | 694 | 12 | 4 | 5 | 6.2 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 | 10.1021/jm950372w | |||
| CHEMBL281206 | 99216 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 630 | 2 | ChEMBL | 694 | 12 | 4 | 5 | 6.2 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 | 10.1021/jm950372w | |||
| 44280122 | 99553 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 169 | 2 | ChEMBL | 640 | 10 | 3 | 4 | 5.7 | CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL283276 | 99553 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 169 | 2 | ChEMBL | 640 | 10 | 3 | 4 | 5.7 | CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm950372w | |||
| 44280993 | 118401 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 678 | 12 | 4 | 5 | 5.5 | CC1(C)CCC(NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL34101 | 118401 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 678 | 12 | 4 | 5 | 5.5 | CC1(C)CCC(NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 | 10.1021/jm950372w | |||
| 39760 | 67786 | None | 2 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 399 | 3 | 2 | 2 | 5.2 | O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@H]1Cc1c[nH]c2ccccc12 | 10.1021/jm00390a019 | |||
| CHEMBL1907931 | 67786 | None | 2 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 399 | 3 | 2 | 2 | 5.2 | O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@H]1Cc1c[nH]c2ccccc12 | 10.1021/jm00390a019 | |||
| 44280398 | 99299 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 601 | 10 | 2 | 4 | 5.2 | CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(Cc1ccccc1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL281728 | 99299 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 601 | 10 | 2 | 4 | 5.2 | CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(Cc1ccccc1)C(=O)O | 10.1021/jm950372w | |||
| 44351519 | 168622 | None | 0 | Rat | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 620 | 8 | 3 | 6 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2)C[C@@H]1C(=O)O | 10.1021/jm970439a | |||
| CHEMBL435404 | 168622 | None | 0 | Rat | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 620 | 8 | 3 | 6 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2)C[C@@H]1C(=O)O | 10.1021/jm970439a | |||
| 44280508 | 99880 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 601 | 10 | 3 | 4 | 5.3 | CC(Cc1ccccc1)(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL285559 | 99880 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 601 | 10 | 3 | 4 | 5.3 | CC(Cc1ccccc1)(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O | 10.1021/jm950372w | |||
| 44280205 | 13073 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 695 | 12 | 4 | 6 | 5.6 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ncccc12 | 10.1021/jm950372w | |||
| CHEMBL1190133 | 13073 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 695 | 12 | 4 | 6 | 5.6 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ncccc12 | 10.1021/jm950372w | |||
| CHEMBL540261 | 13073 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 695 | 12 | 4 | 6 | 5.6 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ncccc12 | 10.1021/jm950372w | |||
| 44280729 | 168332 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 644 | 12 | 4 | 5 | 4.3 | O=C(CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)NCc1ccccc1 | 10.1021/jm950372w | |||
| CHEMBL433621 | 168332 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 644 | 12 | 4 | 5 | 4.3 | O=C(CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)NCc1ccccc1 | 10.1021/jm950372w | |||
| 168269598 | 190118 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 325 | 6 | 0 | 4 | 3.3 | C#CCOC1OC(=O)C(Cl)=C1N(CC(C)C)C1CCCCC1 | 10.1016/j.bmc.2022.116815 | |||
| CHEMBL5171437 | 190118 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 325 | 6 | 0 | 4 | 3.3 | C#CCOC1OC(=O)C(Cl)=C1N(CC(C)C)C1CCCCC1 | 10.1016/j.bmc.2022.116815 | |||
| 44280507 | 113560 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 573 | 9 | 3 | 4 | 5.0 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(C(=O)O)c1ccccc1 | 10.1021/jm950372w | |||
| CHEMBL33200 | 113560 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 573 | 9 | 3 | 4 | 5.0 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(C(=O)O)c1ccccc1 | 10.1021/jm950372w | |||
| 136067266 | 67747 | None | 0 | Human | Functional | pIC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 303 | 2 | 2 | 2 | 3.5 | CC1=N[C@H](Cc2c[nH]c3ccccc23)C(=O)Nc2ccccc21 | 10.1021/jm00390a019 | |||
| CHEMBL1907739 | 67747 | None | 0 | Human | Functional | pIC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 303 | 2 | 2 | 2 | 3.5 | CC1=N[C@H](Cc2c[nH]c3ccccc23)C(=O)Nc2ccccc21 | 10.1021/jm00390a019 | |||
| 4355450 | 136007 | None | 37 | Human | Functional | pIC50 | = | 7.1 | 7.1 | -12 | 3 | ChEMBL | 501 | 6 | 1 | 4 | 6.2 | CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 | 10.1021/jm00067a001 | |||
| CHEMBL37312 | 136007 | None | 37 | Human | Functional | pIC50 | = | 7.1 | 7.1 | -12 | 3 | ChEMBL | 501 | 6 | 1 | 4 | 6.2 | CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 | 10.1021/jm00067a001 | |||
| 44280270 | 99272 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 601 | 10 | 2 | 4 | 5.2 | CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@H](Cc1ccccc1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL281560 | 99272 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 601 | 10 | 2 | 4 | 5.2 | CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@H](Cc1ccccc1)C(=O)O | 10.1021/jm950372w | |||
| 168286058 | 191430 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 295 | 6 | 1 | 4 | 2.8 | CC(C)CNC1=C(Cl)C(=O)OC1OCc1ccccc1 | 10.1016/j.bmc.2022.116815 | |||
| CHEMBL5191421 | 191430 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 295 | 6 | 1 | 4 | 2.8 | CC(C)CNC1=C(Cl)C(=O)OC1OCc1ccccc1 | 10.1016/j.bmc.2022.116815 | |||
| 44280176 | 99364 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 615 | 12 | 3 | 4 | 5.6 | O=C(O)CCC(Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL282099 | 99364 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 615 | 12 | 3 | 4 | 5.6 | O=C(O)CCC(Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 44280973 | 99921 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 704 | 12 | 4 | 5 | 5.9 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NC1CCC2CCCCC2C1 | 10.1021/jm950372w | |||
| CHEMBL285857 | 99921 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 704 | 12 | 4 | 5 | 5.9 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NC1CCC2CCCCC2C1 | 10.1021/jm950372w | |||
| 44280269 | 99271 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 626 | 10 | 4 | 4 | 5.3 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL281559 | 99271 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 626 | 10 | 4 | 4 | 5.3 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm950372w | |||
| 44279939 | 99371 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 637 | 10 | 3 | 4 | 6.0 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1cccc2ccccc12)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL282149 | 99371 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 637 | 10 | 3 | 4 | 6.0 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1cccc2ccccc12)C(=O)O | 10.1021/jm950372w | |||
| 44280501 | 100077 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 698 | 12 | 4 | 5 | 5.6 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NC1CCCc2ccccc21 | 10.1021/jm950372w | |||
| CHEMBL286847 | 100077 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 698 | 12 | 4 | 5 | 5.6 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NC1CCCc2ccccc21 | 10.1021/jm950372w | |||
| 44280414 | 101914 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 708 | 13 | 4 | 5 | 5.9 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCc1cccc2ccccc12 | 10.1021/jm950372w | |||
| CHEMBL30061 | 101914 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 708 | 13 | 4 | 5 | 5.9 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCc1cccc2ccccc12 | 10.1021/jm950372w | |||
| 44280407 | 119775 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 658 | 12 | 3 | 5 | 4.7 | CN(Cc1ccccc1)C(=O)[C@@H](CC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL34743 | 119775 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 658 | 12 | 3 | 5 | 4.7 | CN(Cc1ccccc1)C(=O)[C@@H](CC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 44280380 | 99894 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 553 | 11 | 3 | 4 | 4.8 | CCCCC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL285657 | 99894 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 553 | 11 | 3 | 4 | 4.8 | CCCCC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O | 10.1021/jm950372w | |||
| 44280101 | 99647 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 573 | 9 | 3 | 4 | 5.3 | O=C(O)Cc1cccc(NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)c1 | 10.1021/jm950372w | |||
| CHEMBL283920 | 99647 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 573 | 9 | 3 | 4 | 5.3 | O=C(O)Cc1cccc(NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)c1 | 10.1021/jm950372w | |||
| 44279985 | 103158 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 511 | 8 | 3 | 4 | 3.6 | CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL30764 | 103158 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 511 | 8 | 3 | 4 | 3.6 | CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O | 10.1021/jm950372w | |||
| 887 | 4110 | None | 30 | Rat | Functional | pKd | = | 10.1 | 10.1 | 1 | 3 | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm051219x | |||
| 9870520 | 4110 | None | 30 | Rat | Functional | pKd | = | 10.1 | 10.1 | 1 | 3 | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm051219x | |||
| 9870520.0 | 4110 | None | 30 | Rat | Functional | pKd | = | 10.1 | 10.1 | 1 | 3 | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm051219x | |||
| CHEMBL324547 | 4110 | None | 30 | Rat | Functional | pKd | = | 10.1 | 10.1 | 1 | 3 | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm051219x | |||
| DB12355 | 4110 | None | 30 | Rat | Functional | pKd | = | 10.1 | 10.1 | 1 | 3 | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm051219x | |||
| 887 | 4110 | None | 30 | Rat | Functional | pKd | = | 10.1 | 10.1 | 1 | 3 | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm070139l | |||
| 9870520 | 4110 | None | 30 | Rat | Functional | pKd | = | 10.1 | 10.1 | 1 | 3 | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm070139l | |||
| 9870520.0 | 4110 | None | 30 | Rat | Functional | pKd | = | 10.1 | 10.1 | 1 | 3 | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm070139l | |||
| CHEMBL324547 | 4110 | None | 30 | Rat | Functional | pKd | = | 10.1 | 10.1 | 1 | 3 | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm070139l | |||
| DB12355 | 4110 | None | 30 | Rat | Functional | pKd | = | 10.1 | 10.1 | 1 | 3 | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm070139l | |||
| 11498528 | 72501 | None | 0 | Rat | Functional | pKd | = | 9.2 | 9.2 | - | 0 | ChEMBL | 503 | 7 | 3 | 4 | 6.1 | O=C(O)c1cccc(NC(=O)c2[nH]c(C34CCC(CC3)CC4)nc2COC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
| CHEMBL198933 | 72501 | None | 0 | Rat | Functional | pKd | = | 9.2 | 9.2 | - | 0 | ChEMBL | 503 | 7 | 3 | 4 | 6.1 | O=C(O)c1cccc(NC(=O)c2[nH]c(C34CCC(CC3)CC4)nc2COC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
| 16732163 | 142151 | None | 0 | Rat | Functional | pKd | = | 9.1 | 9.1 | - | 0 | ChEMBL | 544 | 9 | 2 | 5 | 5.2 | O=C(O)Cc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1021/jm070139l | |||
| CHEMBL387948 | 142151 | None | 0 | Rat | Functional | pKd | = | 9.1 | 9.1 | - | 0 | ChEMBL | 544 | 9 | 2 | 5 | 5.2 | O=C(O)Cc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1021/jm070139l | |||
| 16732164 | 143390 | None | 0 | Rat | Functional | pKd | = | 9.1 | 9.1 | - | 0 | ChEMBL | 571 | 8 | 2 | 6 | 5.5 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3ccn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| CHEMBL389711 | 143390 | None | 0 | Rat | Functional | pKd | = | 9.1 | 9.1 | - | 0 | ChEMBL | 571 | 8 | 2 | 6 | 5.5 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3ccn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| 9832467 | 144381 | None | 0 | Rat | Functional | pKd | = | 9.1 | 9.1 | - | 1 | ChEMBL | 477 | 7 | 3 | 4 | 5.9 | O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
| CHEMBL390519 | 144381 | None | 0 | Rat | Functional | pKd | = | 9.1 | 9.1 | - | 1 | ChEMBL | 477 | 7 | 3 | 4 | 5.9 | O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
| 9832467 | 144381 | None | 0 | Rat | Functional | pKd | = | 9.1 | 9.1 | - | 1 | ChEMBL | 477 | 7 | 3 | 4 | 5.9 | O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm070139l | |||
| CHEMBL390519 | 144381 | None | 0 | Rat | Functional | pKd | = | 9.1 | 9.1 | - | 1 | ChEMBL | 477 | 7 | 3 | 4 | 5.9 | O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm070139l | |||
| 11555184 | 166127 | None | 0 | Rat | Functional | pKd | = | 9.1 | 9.1 | - | 1 | ChEMBL | 503 | 7 | 3 | 3 | 7.0 | Cc1ccc(NC(=O)c2[nH]c(C3(C)CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O | 10.1021/jm0490686 | |||
| CHEMBL425574 | 166127 | None | 0 | Rat | Functional | pKd | = | 9.1 | 9.1 | - | 1 | ChEMBL | 503 | 7 | 3 | 3 | 7.0 | Cc1ccc(NC(=O)c2[nH]c(C3(C)CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O | 10.1021/jm0490686 | |||
| 11527738 | 76016 | None | 0 | Rat | Functional | pKd | = | 9.0 | 9.0 | - | 0 | ChEMBL | 518 | 7 | 2 | 5 | 5.2 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm051219x | |||
| CHEMBL205455 | 76016 | None | 0 | Rat | Functional | pKd | = | 9.0 | 9.0 | - | 0 | ChEMBL | 518 | 7 | 2 | 5 | 5.2 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm051219x | |||
| 11527738 | 76016 | None | 0 | Rat | Functional | pKd | = | 9.0 | 9.0 | - | 0 | ChEMBL | 518 | 7 | 2 | 5 | 5.2 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| CHEMBL205455 | 76016 | None | 0 | Rat | Functional | pKd | = | 9.0 | 9.0 | - | 0 | ChEMBL | 518 | 7 | 2 | 5 | 5.2 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| 16733466 | 85551 | None | 0 | Rat | Functional | pKd | = | 8.9 | 8.9 | - | 0 | ChEMBL | 558 | 10 | 2 | 5 | 5.6 | O=C(O)CCc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1021/jm070139l | |||
| CHEMBL227330 | 85551 | None | 0 | Rat | Functional | pKd | = | 8.9 | 8.9 | - | 0 | ChEMBL | 558 | 10 | 2 | 5 | 5.6 | O=C(O)CCc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1021/jm070139l | |||
| 11605814 | 75455 | None | 0 | Rat | Functional | pKd | = | 8.9 | 8.9 | - | 0 | ChEMBL | 503 | 7 | 2 | 5 | 5.5 | CNc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm051219x | |||
| CHEMBL204154 | 75455 | None | 0 | Rat | Functional | pKd | = | 8.9 | 8.9 | - | 0 | ChEMBL | 503 | 7 | 2 | 5 | 5.5 | CNc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm051219x | |||
| 16733469 | 85552 | None | 0 | Rat | Functional | pKd | = | 8.8 | 8.8 | - | 0 | ChEMBL | 576 | 10 | 2 | 6 | 5.8 | O=C(O)CSc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1021/jm070139l | |||
| CHEMBL227333 | 85552 | None | 0 | Rat | Functional | pKd | = | 8.8 | 8.8 | - | 0 | ChEMBL | 576 | 10 | 2 | 6 | 5.8 | O=C(O)CSc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1021/jm070139l | |||
| 11571142 | 135882 | None | 0 | Rat | Functional | pKd | = | 8.8 | 8.8 | - | 0 | ChEMBL | 489 | 7 | 3 | 3 | 6.7 | CC1(c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)CCCCC1 | 10.1021/jm0490686 | |||
| CHEMBL373050 | 135882 | None | 0 | Rat | Functional | pKd | = | 8.8 | 8.8 | - | 0 | ChEMBL | 489 | 7 | 3 | 3 | 6.7 | CC1(c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)CCCCC1 | 10.1021/jm0490686 | |||
| 135423404 | 85546 | None | 0 | Rat | Functional | pKd | = | 8.7 | 8.7 | - | 0 | ChEMBL | 570 | 8 | 2 | 7 | 5.0 | O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(-c2noc(=O)[nH]2)c1 | 10.1021/jm070139l | |||
| CHEMBL227276 | 85546 | None | 0 | Rat | Functional | pKd | = | 8.7 | 8.7 | - | 0 | ChEMBL | 570 | 8 | 2 | 7 | 5.0 | O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(-c2noc(=O)[nH]2)c1 | 10.1021/jm070139l | |||
| 16731872 | 85483 | None | 0 | Rat | Functional | pKd | = | 8.7 | 8.7 | - | 0 | ChEMBL | 530 | 8 | 2 | 5 | 5.3 | O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(C(=O)O)c1 | 10.1021/jm070139l | |||
| CHEMBL226620 | 85483 | None | 0 | Rat | Functional | pKd | = | 8.7 | 8.7 | - | 0 | ChEMBL | 530 | 8 | 2 | 5 | 5.3 | O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(C(=O)O)c1 | 10.1021/jm070139l | |||
| 11679213 | 133612 | None | 0 | Rat | Functional | pKd | = | 8 | 8.0 | - | 0 | ChEMBL | 497 | 7 | 3 | 3 | 6.8 | Cc1ccc(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 | 10.1021/jm0490686 | |||
| CHEMBL370882 | 133612 | None | 0 | Rat | Functional | pKd | = | 8 | 8.0 | - | 0 | ChEMBL | 497 | 7 | 3 | 3 | 6.8 | Cc1ccc(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 | 10.1021/jm0490686 | |||
| 11568611 | 72003 | None | 0 | Rat | Functional | pKd | = | 8.0 | 8.0 | - | 0 | ChEMBL | 449 | 6 | 3 | 3 | 5.8 | CC(C)(C)c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
| CHEMBL197370 | 72003 | None | 0 | Rat | Functional | pKd | = | 8.0 | 8.0 | - | 0 | ChEMBL | 449 | 6 | 3 | 3 | 5.8 | CC(C)(C)c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
| 11571166 | 141401 | None | 0 | Rat | Functional | pKd | = | 7 | 7.0 | - | 0 | ChEMBL | 497 | 7 | 3 | 3 | 6.8 | Cc1cccc(C)c1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
| CHEMBL383386 | 141401 | None | 0 | Rat | Functional | pKd | = | 7 | 7.0 | - | 0 | ChEMBL | 497 | 7 | 3 | 3 | 6.8 | Cc1cccc(C)c1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
| 11592162 | 76556 | None | 0 | Rat | Functional | pKd | = | 7.0 | 7.0 | - | 0 | ChEMBL | 561 | 11 | 2 | 6 | 5.9 | CCOCCNc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm051219x | |||
| CHEMBL206079 | 76556 | None | 0 | Rat | Functional | pKd | = | 7.0 | 7.0 | - | 0 | ChEMBL | 561 | 11 | 2 | 6 | 5.9 | CCOCCNc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm051219x | |||
| 11699148 | 76008 | None | 0 | Rat | Functional | pKd | = | 6.0 | 6.0 | - | 0 | ChEMBL | 511 | 7 | 2 | 6 | 3.4 | CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1021/jm051219x | |||
| CHEMBL205423 | 76008 | None | 0 | Rat | Functional | pKd | = | 6.0 | 6.0 | - | 0 | ChEMBL | 511 | 7 | 2 | 6 | 3.4 | CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1021/jm051219x | |||
| 11584903 | 140826 | None | 0 | Rat | Functional | pKd | = | 6.9 | 6.9 | - | 0 | ChEMBL | 560 | 10 | 2 | 6 | 5.1 | CNCCN(C)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm051219x | |||
| CHEMBL381805 | 140826 | None | 0 | Rat | Functional | pKd | = | 6.9 | 6.9 | - | 0 | ChEMBL | 560 | 10 | 2 | 6 | 5.1 | CNCCN(C)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm051219x | |||
| 11505466 | 72054 | None | 0 | Rat | Functional | pKd | = | 5.9 | 5.9 | - | 0 | ChEMBL | 425 | 7 | 3 | 3 | 5.1 | Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCc2ccccc2)[nH]1 | 10.1021/jm0490686 | |||
| CHEMBL197578 | 72054 | None | 0 | Rat | Functional | pKd | = | 5.9 | 5.9 | - | 0 | ChEMBL | 425 | 7 | 3 | 3 | 5.1 | Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCc2ccccc2)[nH]1 | 10.1021/jm0490686 | |||
| 44451547 | 96765 | None | 0 | Rat | Functional | pKd | = | 7.9 | 7.9 | - | 0 | ChEMBL | 587 | 8 | 2 | 8 | 4.7 | CN(c1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1)c1nn[nH]n1 | 10.1016/j.bmc.2007.12.047 | |||
| CHEMBL264150 | 96765 | None | 0 | Rat | Functional | pKd | = | 7.9 | 7.9 | - | 0 | ChEMBL | 587 | 8 | 2 | 8 | 4.7 | CN(c1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1)c1nn[nH]n1 | 10.1016/j.bmc.2007.12.047 | |||
| 11613212 | 72125 | None | 0 | Rat | Functional | pKd | = | 7.9 | 7.9 | - | 1 | ChEMBL | 513 | 7 | 3 | 4 | 6.4 | Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(COC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 | 10.1021/jm0490686 | |||
| CHEMBL197780 | 72125 | None | 0 | Rat | Functional | pKd | = | 7.9 | 7.9 | - | 1 | ChEMBL | 513 | 7 | 3 | 4 | 6.4 | Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(COC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 | 10.1021/jm0490686 | |||
| 11663308 | 76773 | None | 1 | Rat | Functional | pKd | = | 6.9 | 6.9 | - | 0 | ChEMBL | 497 | 7 | 2 | 5 | 5.0 | CNc1cccc(NC(=O)CN2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm051219x | |||
| CHEMBL206709 | 76773 | None | 1 | Rat | Functional | pKd | = | 6.9 | 6.9 | - | 0 | ChEMBL | 497 | 7 | 2 | 5 | 5.0 | CNc1cccc(NC(=O)CN2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm051219x | |||
| 11613982 | 140512 | None | 0 | Rat | Functional | pKd | = | 6.8 | 6.8 | - | 0 | ChEMBL | 543 | 7 | 1 | 5 | 6.1 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N3CCCC3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm051219x | |||
| CHEMBL380907 | 140512 | None | 0 | Rat | Functional | pKd | = | 6.8 | 6.8 | - | 0 | ChEMBL | 543 | 7 | 1 | 5 | 6.1 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N3CCCC3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm051219x | |||
| 11567687 | 136017 | None | 0 | Rat | Functional | pKd | = | 5.8 | 5.8 | - | 0 | ChEMBL | 407 | 6 | 3 | 3 | 4.8 | Cc1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
| CHEMBL373125 | 136017 | None | 0 | Rat | Functional | pKd | = | 5.8 | 5.8 | - | 0 | ChEMBL | 407 | 6 | 3 | 3 | 4.8 | Cc1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
| 11656338 | 75972 | None | 0 | Rat | Functional | pKd | = | 7.8 | 7.8 | - | 0 | ChEMBL | 504 | 7 | 2 | 5 | 5.0 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CO)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm051219x | |||
| CHEMBL205198 | 75972 | None | 0 | Rat | Functional | pKd | = | 7.8 | 7.8 | - | 0 | ChEMBL | 504 | 7 | 2 | 5 | 5.0 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CO)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm051219x | |||
| 11628273 | 140221 | None | 0 | Rat | Functional | pKd | = | 7.7 | 7.7 | - | 0 | ChEMBL | 559 | 7 | 1 | 6 | 5.3 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N3CCOCC3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm051219x | |||
| CHEMBL380193 | 140221 | None | 0 | Rat | Functional | pKd | = | 7.7 | 7.7 | - | 0 | ChEMBL | 559 | 7 | 1 | 6 | 5.3 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N3CCOCC3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm051219x | |||
| 44451920 | 96179 | None | 0 | Rat | Functional | pKd | = | 7.7 | 7.7 | - | 0 | ChEMBL | 519 | 7 | 2 | 5 | 5.5 | CNc1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1 | 10.1016/j.bmc.2007.12.047 | |||
| CHEMBL260394 | 96179 | None | 0 | Rat | Functional | pKd | = | 7.7 | 7.7 | - | 0 | ChEMBL | 519 | 7 | 2 | 5 | 5.5 | CNc1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1 | 10.1016/j.bmc.2007.12.047 | |||
| 11495719 | 70397 | None | 0 | Rat | Functional | pKd | = | 7.7 | 7.7 | - | 0 | ChEMBL | 431 | 7 | 3 | 3 | 5.8 | Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC2CCCCC2)[nH]1 | 10.1021/jm0490686 | |||
| CHEMBL194514 | 70397 | None | 0 | Rat | Functional | pKd | = | 7.7 | 7.7 | - | 0 | ChEMBL | 431 | 7 | 3 | 3 | 5.8 | Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC2CCCCC2)[nH]1 | 10.1021/jm0490686 | |||
| 44451877 | 96034 | None | 0 | Rat | Functional | pKd | = | 7.7 | 7.7 | - | 0 | ChEMBL | 587 | 7 | 1 | 6 | 6.9 | Cc1nc(-c2cccc(NC(=O)CN3C(=O)N(CC(=O)C(C)(C)C)c4ccccc4N(C4CCCCC4)C3=O)c2)cs1 | 10.1016/j.bmc.2007.12.047 | |||
| CHEMBL259557 | 96034 | None | 0 | Rat | Functional | pKd | = | 7.7 | 7.7 | - | 0 | ChEMBL | 587 | 7 | 1 | 6 | 6.9 | Cc1nc(-c2cccc(NC(=O)CN3C(=O)N(CC(=O)C(C)(C)C)c4ccccc4N(C4CCCCC4)C3=O)c2)cs1 | 10.1016/j.bmc.2007.12.047 | |||
| 11513177 | 72554 | None | 0 | Rat | Functional | pKd | = | 8.6 | 8.6 | - | 0 | ChEMBL | 501 | 7 | 3 | 3 | 6.7 | O=C(O)c1cccc(NC(=O)c2[nH]c(C34CCC(CC3)CC4)nc2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
| CHEMBL199091 | 72554 | None | 0 | Rat | Functional | pKd | = | 8.6 | 8.6 | - | 0 | ChEMBL | 501 | 7 | 3 | 3 | 6.7 | O=C(O)c1cccc(NC(=O)c2[nH]c(C34CCC(CC3)CC4)nc2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
| 16732911 | 143303 | None | 0 | Rat | Functional | pKd | = | 8.6 | 8.6 | - | 0 | ChEMBL | 564 | 9 | 2 | 6 | 5.6 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| CHEMBL389639 | 143303 | None | 0 | Rat | Functional | pKd | = | 8.6 | 8.6 | - | 0 | ChEMBL | 564 | 9 | 2 | 6 | 5.6 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| 11539356 | 71704 | None | 0 | Rat | Functional | pKd | = | 7.7 | 7.7 | - | 0 | ChEMBL | 435 | 7 | 3 | 3 | 5.6 | CC(C)c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
| CHEMBL196441 | 71704 | None | 0 | Rat | Functional | pKd | = | 7.7 | 7.7 | - | 0 | ChEMBL | 435 | 7 | 3 | 3 | 5.6 | CC(C)c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
| 11705988 | 166447 | None | 0 | Rat | Functional | pKd | = | 6.7 | 6.7 | - | 0 | ChEMBL | 498 | 7 | 2 | 6 | 4.4 | CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm051219x | |||
| CHEMBL427387 | 166447 | None | 0 | Rat | Functional | pKd | = | 6.7 | 6.7 | - | 0 | ChEMBL | 498 | 7 | 2 | 6 | 4.4 | CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm051219x | |||
| 16732020 | 85544 | None | 0 | Rat | Functional | pKd | = | 7.6 | 7.6 | - | 0 | ChEMBL | 571 | 8 | 2 | 8 | 4.7 | CN(c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1)c1nn[nH]n1 | 10.1021/jm070139l | |||
| CHEMBL227254 | 85544 | None | 0 | Rat | Functional | pKd | = | 7.6 | 7.6 | - | 0 | ChEMBL | 571 | 8 | 2 | 8 | 4.7 | CN(c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1)c1nn[nH]n1 | 10.1021/jm070139l | |||
| 11612498 | 133631 | None | 0 | Rat | Functional | pKd | = | 6.6 | 6.6 | - | 0 | ChEMBL | 469 | 7 | 3 | 3 | 6.2 | O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccccc3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
| CHEMBL371068 | 133631 | None | 0 | Rat | Functional | pKd | = | 6.6 | 6.6 | - | 0 | ChEMBL | 469 | 7 | 3 | 3 | 6.2 | O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccccc3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
| 11685703 | 71944 | None | 0 | Rat | Functional | pKd | = | 7.6 | 7.6 | - | 0 | ChEMBL | 391 | 7 | 3 | 3 | 4.9 | Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC(C)C)[nH]1 | 10.1021/jm0490686 | |||
| CHEMBL197205 | 71944 | None | 0 | Rat | Functional | pKd | = | 7.6 | 7.6 | - | 0 | ChEMBL | 391 | 7 | 3 | 3 | 4.9 | Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC(C)C)[nH]1 | 10.1021/jm0490686 | |||
| 44451622 | 95969 | None | 0 | Rat | Functional | pKd | = | 7.6 | 7.6 | - | 0 | ChEMBL | 562 | 9 | 2 | 5 | 5.5 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CCC(=O)O)c2)C(=O)N(C2CCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
| CHEMBL259276 | 95969 | None | 0 | Rat | Functional | pKd | = | 7.6 | 7.6 | - | 0 | ChEMBL | 562 | 9 | 2 | 5 | 5.5 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CCC(=O)O)c2)C(=O)N(C2CCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
| 11712880 | 139010 | None | 0 | Rat | Functional | pKd | = | 7.6 | 7.6 | - | 0 | ChEMBL | 490 | 6 | 2 | 5 | 5.2 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm051219x | |||
| CHEMBL378388 | 139010 | None | 0 | Rat | Functional | pKd | = | 7.6 | 7.6 | - | 0 | ChEMBL | 490 | 6 | 2 | 5 | 5.2 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm051219x | |||
| 11511721 | 76129 | None | 0 | Rat | Functional | pKd | = | 7.6 | 7.6 | - | 0 | ChEMBL | 502 | 7 | 2 | 5 | 5.5 | CNc1cccc(NC(=O)C[C@@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm051219x | |||
| CHEMBL205751 | 76129 | None | 0 | Rat | Functional | pKd | = | 7.6 | 7.6 | - | 0 | ChEMBL | 502 | 7 | 2 | 5 | 5.5 | CNc1cccc(NC(=O)C[C@@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm051219x | |||
| 11555166 | 139917 | None | 0 | Rat | Functional | pKd | = | 7.5 | 7.5 | - | 0 | ChEMBL | 502 | 7 | 2 | 5 | 5.5 | CNc1cccc(NC(=O)C[C@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm051219x | |||
| CHEMBL379902 | 139917 | None | 0 | Rat | Functional | pKd | = | 7.5 | 7.5 | - | 0 | ChEMBL | 502 | 7 | 2 | 5 | 5.5 | CNc1cccc(NC(=O)C[C@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm051219x | |||
| 5311201 | 209854 | None | 26 | Rat | Functional | pKd | = | 7.5 | 7.5 | -7 | 7 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm051219x | |||
| CHEMBL9387 | 209854 | None | 26 | Rat | Functional | pKd | = | 7.5 | 7.5 | -7 | 7 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm051219x | |||
| 135529065 | 157107 | None | 0 | Rat | Functional | pKd | = | 8.5 | 8.5 | - | 0 | ChEMBL | 588 | 7 | 2 | 7 | 5.2 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
| CHEMBL407340 | 157107 | None | 0 | Rat | Functional | pKd | = | 8.5 | 8.5 | - | 0 | ChEMBL | 588 | 7 | 2 | 7 | 5.2 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
| 11497371 | 70654 | None | 0 | Rat | Functional | pKd | = | 8.5 | 8.5 | - | 1 | ChEMBL | 525 | 7 | 3 | 3 | 7.4 | Cc1cc(C)c(-c2nc(C(=O)Nc3ccc(C)c(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 | 10.1021/jm0490686 | |||
| CHEMBL195007 | 70654 | None | 0 | Rat | Functional | pKd | = | 8.5 | 8.5 | - | 1 | ChEMBL | 525 | 7 | 3 | 3 | 7.4 | Cc1cc(C)c(-c2nc(C(=O)Nc3ccc(C)c(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 | 10.1021/jm0490686 | |||
| 11605694 | 168756 | None | 0 | Rat | Functional | pKd | = | 7.5 | 7.5 | - | 0 | ChEMBL | 497 | 7 | 3 | 3 | 6.8 | Cc1ccc(NC(=O)c2[nH]c(-c3ccccc3C)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O | 10.1021/jm0490686 | |||
| CHEMBL436314 | 168756 | None | 0 | Rat | Functional | pKd | = | 7.5 | 7.5 | - | 0 | ChEMBL | 497 | 7 | 3 | 3 | 6.8 | Cc1ccc(NC(=O)c2[nH]c(-c3ccccc3C)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O | 10.1021/jm0490686 | |||
| 11576771 | 74457 | None | 0 | Rat | Functional | pKd | = | 7.4 | 7.4 | - | 0 | ChEMBL | 489 | 6 | 2 | 5 | 5.0 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm051219x | |||
| CHEMBL202680 | 74457 | None | 0 | Rat | Functional | pKd | = | 7.4 | 7.4 | - | 0 | ChEMBL | 489 | 6 | 2 | 5 | 5.0 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm051219x | |||
| 44451581 | 95878 | None | 0 | Rat | Functional | pKd | = | 8.4 | 8.4 | - | 0 | ChEMBL | 594 | 9 | 2 | 6 | 6.0 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)C(=O)N(C2CCCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
| CHEMBL258863 | 95878 | None | 0 | Rat | Functional | pKd | = | 8.4 | 8.4 | - | 0 | ChEMBL | 594 | 9 | 2 | 6 | 6.0 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)C(=O)N(C2CCCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
| 16731874 | 85492 | None | 0 | Rat | Functional | pKd | = | 8.4 | 8.4 | - | 0 | ChEMBL | 546 | 9 | 2 | 5 | 5.5 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| CHEMBL226675 | 85492 | None | 0 | Rat | Functional | pKd | = | 8.4 | 8.4 | - | 0 | ChEMBL | 546 | 9 | 2 | 5 | 5.5 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| 11540160 | 71472 | None | 0 | Rat | Functional | pKd | = | 8.3 | 8.3 | - | 1 | ChEMBL | 475 | 7 | 3 | 3 | 6.6 | O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
| CHEMBL196133 | 71472 | None | 0 | Rat | Functional | pKd | = | 8.3 | 8.3 | - | 1 | ChEMBL | 475 | 7 | 3 | 3 | 6.6 | O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
| 44451843 | 159533 | None | 0 | Rat | Functional | pKd | = | 7.4 | 7.4 | - | 0 | ChEMBL | 562 | 8 | 2 | 5 | 5.5 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)C(=O)N(C2CCCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
| CHEMBL410114 | 159533 | None | 0 | Rat | Functional | pKd | = | 7.4 | 7.4 | - | 0 | ChEMBL | 562 | 8 | 2 | 5 | 5.5 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)C(=O)N(C2CCCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
| 136036823 | 155768 | None | 0 | Rat | Functional | pKd | = | 7.4 | 7.4 | - | 0 | ChEMBL | 574 | 7 | 2 | 7 | 4.8 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
| CHEMBL404967 | 155768 | None | 0 | Rat | Functional | pKd | = | 7.4 | 7.4 | - | 0 | ChEMBL | 574 | 7 | 2 | 7 | 4.8 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
| 11571140 | 71725 | None | 0 | Rat | Functional | pKd | = | 8.3 | 8.3 | - | 0 | ChEMBL | 489 | 7 | 3 | 3 | 6.9 | O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
| CHEMBL196517 | 71725 | None | 0 | Rat | Functional | pKd | = | 8.3 | 8.3 | - | 0 | ChEMBL | 489 | 7 | 3 | 3 | 6.9 | O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
| 11512112 | 75619 | None | 0 | Rat | Functional | pKd | = | 7.3 | 7.3 | - | 0 | ChEMBL | 532 | 8 | 2 | 6 | 4.9 | CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 | 10.1021/jm051219x | |||
| CHEMBL204683 | 75619 | None | 0 | Rat | Functional | pKd | = | 7.3 | 7.3 | - | 0 | ChEMBL | 532 | 8 | 2 | 6 | 4.9 | CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 | 10.1021/jm051219x | |||
| 11643045 | 72162 | None | 0 | Rat | Functional | pKd | = | 6.3 | 6.3 | - | 0 | ChEMBL | 511 | 9 | 3 | 3 | 6.8 | Cc1ccccc1-c1nc(C(=O)Nc2cccc(CCC(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
| CHEMBL197873 | 72162 | None | 0 | Rat | Functional | pKd | = | 6.3 | 6.3 | - | 0 | ChEMBL | 511 | 9 | 3 | 3 | 6.8 | Cc1ccccc1-c1nc(C(=O)Nc2cccc(CCC(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
| 11698512 | 168358 | None | 0 | Rat | Functional | pKd | = | 7.3 | 7.3 | - | 0 | ChEMBL | 435 | 8 | 3 | 3 | 5.5 | CCCc1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
| CHEMBL433776 | 168358 | None | 0 | Rat | Functional | pKd | = | 7.3 | 7.3 | - | 0 | ChEMBL | 435 | 8 | 3 | 3 | 5.5 | CCCc1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
| 11542079 | 71746 | None | 0 | Rat | Functional | pKd | = | 7.2 | 7.2 | - | 0 | ChEMBL | 483 | 7 | 3 | 3 | 6.5 | Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
| CHEMBL196580 | 71746 | None | 0 | Rat | Functional | pKd | = | 7.2 | 7.2 | - | 0 | ChEMBL | 483 | 7 | 3 | 3 | 6.5 | Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
| 11518283 | 166255 | None | 0 | Rat | Functional | pKd | = | 8.2 | 8.2 | - | 0 | ChEMBL | 461 | 7 | 3 | 3 | 6.2 | O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
| CHEMBL426290 | 166255 | None | 0 | Rat | Functional | pKd | = | 8.2 | 8.2 | - | 0 | ChEMBL | 461 | 7 | 3 | 3 | 6.2 | O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
| 16732753 | 144073 | None | 0 | Rat | Functional | pKd | = | 8.1 | 8.1 | - | 0 | ChEMBL | 552 | 8 | 2 | 5 | 5.7 | Cc1ccccc1C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| CHEMBL390276 | 144073 | None | 0 | Rat | Functional | pKd | = | 8.1 | 8.1 | - | 0 | ChEMBL | 552 | 8 | 2 | 5 | 5.7 | Cc1ccccc1C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| 16732019 | 85468 | None | 0 | Rat | Functional | pKd | = | 8.1 | 8.1 | - | 0 | ChEMBL | 542 | 7 | 2 | 7 | 4.6 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| CHEMBL226533 | 85468 | None | 0 | Rat | Functional | pKd | = | 8.1 | 8.1 | - | 0 | ChEMBL | 542 | 7 | 2 | 7 | 4.6 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| 11541870 | 71475 | None | 0 | Rat | Functional | pKd | = | 7.2 | 7.2 | - | 0 | ChEMBL | 433 | 7 | 3 | 3 | 5.4 | O=C(O)c1cccc(NC(=O)c2[nH]c(C3CC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
| CHEMBL196141 | 71475 | None | 0 | Rat | Functional | pKd | = | 7.2 | 7.2 | - | 0 | ChEMBL | 433 | 7 | 3 | 3 | 5.4 | O=C(O)c1cccc(NC(=O)c2[nH]c(C3CC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
| 44451523 | 95996 | None | 0 | Rat | Functional | pKd | = | 6.2 | 6.2 | - | 0 | ChEMBL | 541 | 7 | 2 | 5 | 4.1 | O=C(CN1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(c2ccccc2)C1=O)Nc1cccc(C(=O)O)c1 | 10.1016/j.bmc.2007.12.047 | |||
| CHEMBL259390 | 95996 | None | 0 | Rat | Functional | pKd | = | 6.2 | 6.2 | - | 0 | ChEMBL | 541 | 7 | 2 | 5 | 4.1 | O=C(CN1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(c2ccccc2)C1=O)Nc1cccc(C(=O)O)c1 | 10.1016/j.bmc.2007.12.047 | |||
| 443375 | 210065 | None | 33 | Rat | Functional | pKd | = | 6.1 | 6.1 | -4466 | 9 | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm051219x | |||
| CHEMBL9506 | 210065 | None | 33 | Rat | Functional | pKd | = | 6.1 | 6.1 | -4466 | 9 | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm051219x | |||
| 11505870 | 72532 | None | 0 | Rat | Functional | pKd | = | 6.1 | 6.1 | - | 0 | ChEMBL | 526 | 8 | 3 | 4 | 6.6 | Cc1ccccc1-c1nc(CCC23CC4CC(CC(C4)C2)C3)c(C(=O)Nc2ccc(N(C)C)c(C(=O)O)c2)[nH]1 | 10.1021/jm0490686 | |||
| CHEMBL199032 | 72532 | None | 0 | Rat | Functional | pKd | = | 6.1 | 6.1 | - | 0 | ChEMBL | 526 | 8 | 3 | 4 | 6.6 | Cc1ccccc1-c1nc(CCC23CC4CC(CC(C4)C2)C3)c(C(=O)Nc2ccc(N(C)C)c(C(=O)O)c2)[nH]1 | 10.1021/jm0490686 | |||
| 11613179 | 71812 | None | 0 | Rat | Functional | pKd | = | 8.1 | 8.1 | - | 0 | ChEMBL | 511 | 7 | 3 | 3 | 7.1 | Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 | 10.1021/jm0490686 | |||
| CHEMBL196745 | 71812 | None | 0 | Rat | Functional | pKd | = | 8.1 | 8.1 | - | 0 | ChEMBL | 511 | 7 | 3 | 3 | 7.1 | Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 | 10.1021/jm0490686 | |||
| 11511706 | 72285 | None | 0 | Rat | Functional | pKd | = | 7.1 | 7.1 | - | 0 | ChEMBL | 501 | 7 | 3 | 3 | 6.6 | Cc1ccccc1-c1nc(C(=O)Nc2ccc(F)c(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
| CHEMBL198225 | 72285 | None | 0 | Rat | Functional | pKd | = | 7.1 | 7.1 | - | 0 | ChEMBL | 501 | 7 | 3 | 3 | 6.6 | Cc1ccccc1-c1nc(C(=O)Nc2ccc(F)c(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 | 10.1021/jm0490686 | |||
| 136036821 | 95861 | None | 0 | Rat | Functional | pKd | = | 7.1 | 7.1 | - | 0 | ChEMBL | 602 | 9 | 2 | 7 | 5.6 | CC(C)(C)C(=O)CN1C(=O)N(CCCC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
| CHEMBL258782 | 95861 | None | 0 | Rat | Functional | pKd | = | 7.1 | 7.1 | - | 0 | ChEMBL | 602 | 9 | 2 | 7 | 5.6 | CC(C)(C)C(=O)CN1C(=O)N(CCCC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCC2)c2ccccc21 | 10.1016/j.bmc.2007.12.047 | |||
| 11642370 | 140258 | None | 0 | Rat | Functional | pKd | = | 6.1 | 6.1 | - | 0 | ChEMBL | 540 | 7 | 1 | 6 | 5.7 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-n3ccnc3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm051219x | |||
| CHEMBL380363 | 140258 | None | 0 | Rat | Functional | pKd | = | 6.1 | 6.1 | - | 0 | ChEMBL | 540 | 7 | 1 | 6 | 5.7 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-n3ccnc3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm051219x | |||
| 135610887 | 85476 | None | 0 | Rat | Functional | pKd | = | 8.0 | 8.0 | - | 0 | ChEMBL | 558 | 7 | 2 | 7 | 4.8 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| CHEMBL226583 | 85476 | None | 0 | Rat | Functional | pKd | = | 8.0 | 8.0 | - | 0 | ChEMBL | 558 | 7 | 2 | 7 | 4.8 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| 16732909 | 85491 | None | 0 | Rat | Functional | pKd | = | 8.0 | 8.0 | - | 0 | ChEMBL | 532 | 8 | 2 | 5 | 5.1 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| CHEMBL226673 | 85491 | None | 0 | Rat | Functional | pKd | = | 8.0 | 8.0 | - | 0 | ChEMBL | 532 | 8 | 2 | 5 | 5.1 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| 11663565 | 76223 | None | 0 | Rat | Functional | pKd | = | 7.0 | 7.0 | - | 0 | ChEMBL | 517 | 7 | 1 | 5 | 5.5 | CN(C)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm051219x | |||
| CHEMBL205831 | 76223 | None | 0 | Rat | Functional | pKd | = | 7.0 | 7.0 | - | 0 | ChEMBL | 517 | 7 | 1 | 5 | 5.5 | CN(C)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm051219x | |||
| 9832467 | 144381 | None | 0 | Dog | Functional | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 477 | 7 | 3 | 4 | 5.9 | O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm070139l | |||
| CHEMBL390519 | 144381 | None | 0 | Dog | Functional | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 477 | 7 | 3 | 4 | 5.9 | O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm070139l | |||
| 11527738 | 76016 | None | 0 | Dog | Functional | pKi | = | 7.9 | 7.9 | - | 0 | ChEMBL | 518 | 7 | 2 | 5 | 5.2 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| CHEMBL205455 | 76016 | None | 0 | Dog | Functional | pKi | = | 7.9 | 7.9 | - | 0 | ChEMBL | 518 | 7 | 2 | 5 | 5.2 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| CHEMBL2370598 | 212337 | None | 0 | Human | Functional | pKi | = | 6.9 | 6.9 | - | 0 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)C[C@@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/jm00126a007 | |||||
| 16732164 | 143390 | None | 0 | Dog | Functional | pKi | = | 8.6 | 8.6 | - | 0 | ChEMBL | 571 | 8 | 2 | 6 | 5.5 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3ccn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| CHEMBL389711 | 143390 | None | 0 | Dog | Functional | pKi | = | 8.6 | 8.6 | - | 0 | ChEMBL | 571 | 8 | 2 | 6 | 5.5 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3ccn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| 16732753 | 144073 | None | 0 | Dog | Functional | pKi | = | 7.6 | 7.6 | - | 0 | ChEMBL | 552 | 8 | 2 | 5 | 5.7 | Cc1ccccc1C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| CHEMBL390276 | 144073 | None | 0 | Dog | Functional | pKi | = | 7.6 | 7.6 | - | 0 | ChEMBL | 552 | 8 | 2 | 5 | 5.7 | Cc1ccccc1C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| 16732019 | 85468 | None | 0 | Dog | Functional | pKi | = | 8.5 | 8.5 | - | 0 | ChEMBL | 542 | 7 | 2 | 7 | 4.6 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| CHEMBL226533 | 85468 | None | 0 | Dog | Functional | pKi | = | 8.5 | 8.5 | - | 0 | ChEMBL | 542 | 7 | 2 | 7 | 4.6 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| 16733466 | 85551 | None | 0 | Dog | Functional | pKi | = | 8.4 | 8.4 | - | 0 | ChEMBL | 558 | 10 | 2 | 5 | 5.6 | O=C(O)CCc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1021/jm070139l | |||
| CHEMBL227330 | 85551 | None | 0 | Dog | Functional | pKi | = | 8.4 | 8.4 | - | 0 | ChEMBL | 558 | 10 | 2 | 5 | 5.6 | O=C(O)CCc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1021/jm070139l | |||
| 135610887 | 85476 | None | 0 | Dog | Functional | pKi | = | 8.4 | 8.4 | - | 0 | ChEMBL | 558 | 7 | 2 | 7 | 4.8 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| CHEMBL226583 | 85476 | None | 0 | Dog | Functional | pKi | = | 8.4 | 8.4 | - | 0 | ChEMBL | 558 | 7 | 2 | 7 | 4.8 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| 135423404 | 85546 | None | 0 | Dog | Functional | pKi | = | 8.4 | 8.4 | - | 0 | ChEMBL | 570 | 8 | 2 | 7 | 5.0 | O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(-c2noc(=O)[nH]2)c1 | 10.1021/jm070139l | |||
| CHEMBL227276 | 85546 | None | 0 | Dog | Functional | pKi | = | 8.4 | 8.4 | - | 0 | ChEMBL | 570 | 8 | 2 | 7 | 5.0 | O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(-c2noc(=O)[nH]2)c1 | 10.1021/jm070139l | |||
| 16732020 | 85544 | None | 0 | Dog | Functional | pKi | = | 8.3 | 8.3 | - | 0 | ChEMBL | 571 | 8 | 2 | 8 | 4.7 | CN(c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1)c1nn[nH]n1 | 10.1021/jm070139l | |||
| CHEMBL227254 | 85544 | None | 0 | Dog | Functional | pKi | = | 8.3 | 8.3 | - | 0 | ChEMBL | 571 | 8 | 2 | 8 | 4.7 | CN(c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1)c1nn[nH]n1 | 10.1021/jm070139l | |||
| 16733469 | 85552 | None | 0 | Dog | Functional | pKi | = | 8.3 | 8.3 | - | 0 | ChEMBL | 576 | 10 | 2 | 6 | 5.8 | O=C(O)CSc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1021/jm070139l | |||
| CHEMBL227333 | 85552 | None | 0 | Dog | Functional | pKi | = | 8.3 | 8.3 | - | 0 | ChEMBL | 576 | 10 | 2 | 6 | 5.8 | O=C(O)CSc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1021/jm070139l | |||
| 16732909 | 85491 | None | 0 | Dog | Functional | pKi | = | 8.3 | 8.3 | - | 0 | ChEMBL | 532 | 8 | 2 | 5 | 5.1 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| CHEMBL226673 | 85491 | None | 0 | Dog | Functional | pKi | = | 8.3 | 8.3 | - | 0 | ChEMBL | 532 | 8 | 2 | 5 | 5.1 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| 16732911 | 143303 | None | 0 | Dog | Functional | pKi | = | 8.2 | 8.2 | - | 0 | ChEMBL | 564 | 9 | 2 | 6 | 5.6 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| CHEMBL389639 | 143303 | None | 0 | Dog | Functional | pKi | = | 8.2 | 8.2 | - | 0 | ChEMBL | 564 | 9 | 2 | 6 | 5.6 | CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm070139l | |||
| 16732163 | 142151 | None | 0 | Dog | Functional | pKi | = | 8.2 | 8.2 | - | 0 | ChEMBL | 544 | 9 | 2 | 5 | 5.2 | O=C(O)Cc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1021/jm070139l | |||
| CHEMBL387948 | 142151 | None | 0 | Dog | Functional | pKi | = | 8.2 | 8.2 | - | 0 | ChEMBL | 544 | 9 | 2 | 5 | 5.2 | O=C(O)Cc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1021/jm070139l | |||
| 16731872 | 85483 | None | 0 | Dog | Functional | pKi | = | 8.2 | 8.2 | - | 0 | ChEMBL | 530 | 8 | 2 | 5 | 5.3 | O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(C(=O)O)c1 | 10.1021/jm070139l | |||
| CHEMBL226620 | 85483 | None | 0 | Dog | Functional | pKi | = | 8.2 | 8.2 | - | 0 | ChEMBL | 530 | 8 | 2 | 5 | 5.3 | O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(C(=O)O)c1 | 10.1021/jm070139l | |||
| 5489450 | 206 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | Guide to Pharmacology | None | None | None | None | 8914862 | |||||
| 894 | 206 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | Guide to Pharmacology | None | None | None | None | 8914862 | |||||
| 4329839 | 819 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 158 | 2 | Guide to Pharmacology | None | None | None | None | 8349705 | |||||
| 861 | 819 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 158 | 2 | Guide to Pharmacology | None | None | None | None | 8349705 | |||||
| 2802894 | 2403 | None | 25 | Rat | Functional | pIC50 | = | 7.5 | 7.5 | -1 | 3 | Guide to Pharmacology | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 | 21228869 | |||
| 3509 | 2403 | None | 25 | Rat | Functional | pIC50 | = | 7.5 | 7.5 | -1 | 3 | Guide to Pharmacology | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 | 21228869 | |||
| CHEMBL333081 | 2403 | None | 25 | Rat | Functional | pIC50 | = | 7.5 | 7.5 | -1 | 3 | Guide to Pharmacology | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 | 21228869 | |||
| 3523 | 3381 | None | 0 | Rat | Functional | pIC50 | = | 8 | 8.0 | - | 1 | Guide to Pharmacology | 554 | 11 | 3 | 6 | 2.9 | COc1cccc(c1)N(C(=O)CNC(=O)Nc1cccc(c1)CCS(=O)(=O)O)CC(=O)N(c1ccccc1)C | 10385255 | |||
| 5311414 | 3381 | None | 0 | Rat | Functional | pIC50 | = | 8 | 8.0 | - | 1 | Guide to Pharmacology | 554 | 11 | 3 | 6 | 2.9 | COc1cccc(c1)N(C(=O)CNC(=O)Nc1cccc(c1)CCS(=O)(=O)O)CC(=O)N(c1ccccc1)C | 10385255 | |||
| 16168172 | 1771 | None | 0 | Mouse | Functional | pIC50 | = | 8.3 | 8.3 | 158 | 2 | Guide to Pharmacology | None | None | None | None | 1975695 | |||||
| 3559 | 1771 | None | 0 | Mouse | Functional | pIC50 | = | 8.3 | 8.3 | 158 | 2 | Guide to Pharmacology | None | None | None | None | 1975695 | |||||
| 104929 | 2219 | None | 5 | Human | Functional | pIC50 | = | 8.4 | 8.4 | -1 | 3 | Guide to Pharmacology | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 7681836 | |||
| 3477 | 2219 | None | 5 | Human | Functional | pIC50 | = | 8.4 | 8.4 | -1 | 3 | Guide to Pharmacology | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 7681836 | |||
| 879 | 2219 | None | 5 | Human | Functional | pIC50 | = | 8.4 | 8.4 | -1 | 3 | Guide to Pharmacology | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 7681836 | |||
| CHEMBL289498 | 2219 | None | 5 | Human | Functional | pIC50 | = | 8.4 | 8.4 | -1 | 3 | Guide to Pharmacology | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 7681836 | |||
| 3084441 | 1394 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | Guide to Pharmacology | None | None | None | None | 7681836 | |||||
| 3725 | 1394 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | Guide to Pharmacology | None | None | None | None | 7681836 | |||||
| 11307323 | 2138 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | Guide to Pharmacology | 546 | 6 | 2 | 5 | 5.0 | Brc1ccc(c(c1)NS(=O)(=O)c1cccc2c1nccn2)C(=O)N[C@@H](c1ccc(cc1F)F)C | 21493750 | |||
| 6665 | 2138 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | Guide to Pharmacology | 546 | 6 | 2 | 5 | 5.0 | Brc1ccc(c(c1)NS(=O)(=O)c1cccc2c1nccn2)C(=O)N[C@@H](c1ccc(cc1F)F)C | 21493750 | |||
| 3948 | 3009 | None | 0 | Rat | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | Guide to Pharmacology | None | None | None | None | 8720482 | |||||
| 5491702 | 3009 | None | 0 | Rat | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | Guide to Pharmacology | None | None | None | None | 8720482 | |||||
| 444007 | 3043 | None | 0 | Mouse | Functional | pIC50 | = | 9.1 | 9.1 | 794 | 2 | Guide to Pharmacology | None | None | None | None | 1975695 | |||||
| 870 | 3043 | None | 0 | Mouse | Functional | pIC50 | = | 9.1 | 9.1 | 794 | 2 | Guide to Pharmacology | None | None | None | None | 1975695 | |||||
| DB00183 | 3043 | None | 0 | Mouse | Functional | pIC50 | = | 9.1 | 9.1 | 794 | 2 | Guide to Pharmacology | None | None | None | None | 1975695 | |||||
| 132980 | 2240 | None | 13 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 6456 | 2 | Guide to Pharmacology | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 | 11738246 | |||
| 881 | 2240 | None | 13 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 6456 | 2 | Guide to Pharmacology | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 | 11738246 | |||
| CHEMBL420783 | 2240 | None | 13 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 6456 | 2 | Guide to Pharmacology | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 | 11738246 | |||
| 122130 | 4115 | None | 31 | Human | Functional | pIC50 | = | 9.2 | 9.2 | -5 | 4 | Guide to Pharmacology | 516 | 6 | 2 | 4 | 5.5 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 | 11738246 | |||
| 888 | 4115 | None | 31 | Human | Functional | pIC50 | = | 9.2 | 9.2 | -5 | 4 | Guide to Pharmacology | 516 | 6 | 2 | 4 | 5.5 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 | 11738246 | |||
| CHEMBL115121 | 4115 | None | 31 | Human | Functional | pIC50 | = | 9.2 | 9.2 | -5 | 4 | Guide to Pharmacology | 516 | 6 | 2 | 4 | 5.5 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 | 11738246 | |||
| 3503 | 1893 | None | 18 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | Guide to Pharmacology | 534 | 5 | 2 | 3 | 6.1 | O=C(N[C@H]1C(=O)N(c2ccccc2)c2c(N(C1=O)CC13CC4CC(C3)CC(C1)C4)cccc2)Nc1ccccc1 | 11020274 | |||
| 5311147 | 1893 | None | 18 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | Guide to Pharmacology | 534 | 5 | 2 | 3 | 6.1 | O=C(N[C@H]1C(=O)N(c2ccccc2)c2c(N(C1=O)CC13CC4CC(C3)CC(C1)C4)cccc2)Nc1ccccc1 | 11020274 | |||
| CHEMBL329305 | 1893 | None | 18 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | Guide to Pharmacology | 534 | 5 | 2 | 3 | 6.1 | O=C(N[C@H]1C(=O)N(c2ccccc2)c2c(N(C1=O)CC13CC4CC(C3)CC(C1)C4)cccc2)Nc1ccccc1 | 11020274 | |||
| 862 | 821 | None | 0 | Mouse | Functional | pIC50 | = | 9.5 | 9.5 | 1 | 2 | Guide to Pharmacology | None | None | None | None | 12370550 | |||||
| 887 | 4110 | None | 30 | Human | Functional | pIC50 | = | 9.7 | 9.7 | -1 | 3 | Guide to Pharmacology | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 22607579 | |||
| 887 | 4110 | None | 30 | Human | Functional | pIC50 | = | 9.7 | 9.7 | -1 | 3 | Guide to Pharmacology | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 9042983 | |||
| 9870520 | 4110 | None | 30 | Human | Functional | pIC50 | = | 9.7 | 9.7 | -1 | 3 | Guide to Pharmacology | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 22607579 | |||
| 9870520 | 4110 | None | 30 | Human | Functional | pIC50 | = | 9.7 | 9.7 | -1 | 3 | Guide to Pharmacology | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 9042983 | |||
| 9870520.0 | 4110 | None | 30 | Human | Functional | pIC50 | = | 9.7 | 9.7 | -1 | 3 | Guide to Pharmacology | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 22607579 | |||
| 9870520.0 | 4110 | None | 30 | Human | Functional | pIC50 | = | 9.7 | 9.7 | -1 | 3 | Guide to Pharmacology | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 9042983 | |||
| CHEMBL324547 | 4110 | None | 30 | Human | Functional | pIC50 | = | 9.7 | 9.7 | -1 | 3 | Guide to Pharmacology | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 22607579 | |||
| CHEMBL324547 | 4110 | None | 30 | Human | Functional | pIC50 | = | 9.7 | 9.7 | -1 | 3 | Guide to Pharmacology | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 9042983 | |||
| DB12355 | 4110 | None | 30 | Human | Functional | pIC50 | = | 9.7 | 9.7 | -1 | 3 | Guide to Pharmacology | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 22607579 | |||
| DB12355 | 4110 | None | 30 | Human | Functional | pIC50 | = | 9.7 | 9.7 | -1 | 3 | Guide to Pharmacology | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 9042983 | |||
| 44457632 | 3027 | None | 0 | Mouse | Functional | pIC50 | None | 10.1 | 10.1 | - | 1 | Guide to Pharmacology | 575 | 10 | 4 | 4 | 5.4 | OC(=O)CC(NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccc(cc1)F | 8931944 | |||
| 905 | 3027 | None | 0 | Mouse | Functional | pIC50 | None | 10.1 | 10.1 | - | 1 | Guide to Pharmacology | 575 | 10 | 4 | 4 | 5.4 | OC(=O)CC(NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccc(cc1)F | 8931944 | |||
| 3960 | 2345 | None | 18 | Human | Functional | pIC50 | None | 5.5 | 5.5 | -131 | 4 | Guide to Pharmacology | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 8914862 | |||
| 891 | 2345 | None | 18 | Human | Functional | pIC50 | None | 5.5 | 5.5 | -131 | 4 | Guide to Pharmacology | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 8914862 | |||
| CHEMBL24938 | 2345 | None | 18 | Human | Functional | pIC50 | None | 5.5 | 5.5 | -131 | 4 | Guide to Pharmacology | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 8914862 | |||
| 5311148 | 1896 | None | 8 | Human | Functional | pIC50 | None | 6 | 6.0 | -41 | 2 | Guide to Pharmacology | 587 | 8 | 1 | 5 | 5.9 | COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C | 9276016 | |||
| 865 | 1896 | None | 8 | Human | Functional | pIC50 | None | 6 | 6.0 | -41 | 2 | Guide to Pharmacology | 587 | 8 | 1 | 5 | 5.9 | COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C | 9276016 | |||
| CHEMBL293226 | 1896 | None | 8 | Human | Functional | pIC50 | None | 6 | 6.0 | -41 | 2 | Guide to Pharmacology | 587 | 8 | 1 | 5 | 5.9 | COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C | 9276016 | |||
| 904 | 3026 | None | 12 | Rat | Functional | pIC50 | None | 6.6 | 6.6 | -44 | 3 | Guide to Pharmacology | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 7684452 | |||
| 9915756 | 3026 | None | 12 | Rat | Functional | pIC50 | None | 6.6 | 6.6 | -44 | 3 | Guide to Pharmacology | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 7684452 | |||
| CHEMBL2111204 | 3026 | None | 12 | Rat | Functional | pIC50 | None | 6.6 | 6.6 | -44 | 3 | Guide to Pharmacology | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 7684452 | |||
| CHEMBL356898 | 3026 | None | 12 | Rat | Functional | pIC50 | None | 6.6 | 6.6 | -44 | 3 | Guide to Pharmacology | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 7684452 | |||
| 54695534 | 3789 | None | 4 | Human | Functional | pIC50 | None | 6.7 | 6.7 | -54 | 2 | Guide to Pharmacology | 570 | 2 | 3 | 8 | 4.5 | OC1C/C=C/CC(C)C2C(SCC2C(=O)C2=C(OC3(C(C/C=C/C=C/C1)C=C(C)C(C3)C)C2=O)O)C(=O)C(=O)O | 8233061 | |||
| 910 | 3789 | None | 4 | Human | Functional | pIC50 | None | 6.7 | 6.7 | -54 | 2 | Guide to Pharmacology | 570 | 2 | 3 | 8 | 4.5 | OC1C/C=C/CC(C)C2C(SCC2C(=O)C2=C(OC3(C(C/C=C/C=C/C1)C=C(C)C(C3)C)C2=O)O)C(=O)C(=O)O | 8233061 | |||
| CHEMBL3576924 | 3789 | None | 4 | Human | Functional | pIC50 | None | 6.7 | 6.7 | -54 | 2 | Guide to Pharmacology | 570 | 2 | 3 | 8 | 4.5 | OC1C/C=C/CC(C)C2C(SCC2C(=O)C2=C(OC3(C(C/C=C/C=C/C1)C=C(C)C(C3)C)C2=O)O)C(=O)C(=O)O | 8233061 | |||
| 3476 | 1400 | None | 2 | Human | Functional | pIC50 | None | 6.8 | 6.8 | -870 | 2 | Guide to Pharmacology | 408 | 3 | 2 | 3 | 3.7 | O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 7681836 | |||
| 59751 | 1400 | None | 2 | Human | Functional | pIC50 | None | 6.8 | 6.8 | -870 | 2 | Guide to Pharmacology | 408 | 3 | 2 | 3 | 3.7 | O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 7681836 | |||
| 878 | 1400 | None | 2 | Human | Functional | pIC50 | None | 6.8 | 6.8 | -870 | 2 | Guide to Pharmacology | 408 | 3 | 2 | 3 | 3.7 | O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 7681836 | |||
| CHEMBL39263 | 1400 | None | 2 | Human | Functional | pIC50 | None | 6.8 | 6.8 | -870 | 2 | Guide to Pharmacology | 408 | 3 | 2 | 3 | 3.7 | O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 | 7681836 | |||
| 6956374 | 2405 | None | 4 | Human | Functional | pIC50 | None | 7 | 7.0 | 3 | 3 | Guide to Pharmacology | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 | 8914862 | |||
| 902 | 2405 | None | 4 | Human | Functional | pIC50 | None | 7 | 7.0 | 3 | 3 | Guide to Pharmacology | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 | 8914862 | |||
| CHEMBL117281 | 2405 | None | 4 | Human | Functional | pIC50 | None | 7 | 7.0 | 3 | 3 | Guide to Pharmacology | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 | 8914862 | |||
| 898 | 2125 | None | 0 | Rat | Functional | pIC50 | None | 8.4 | 8.4 | - | 1 | Guide to Pharmacology | None | None | None | None | 1698251 | |||||
| 3074331 | 925 | None | 0 | Mouse | Functional | pIC50 | None | 8.5 | 8.5 | - | 1 | Guide to Pharmacology | 493 | 6 | 4 | 4 | 4.6 | O=C(N[C@@](C(=O)N[C@H]1CCCC[C@@H]1O)(Cc1c[nH]c2c1cccc2)C)OC12CC3CC(C2)CC(C1)C3 | 9438020 | |||
| 872 | 925 | None | 0 | Mouse | Functional | pIC50 | None | 8.5 | 8.5 | - | 1 | Guide to Pharmacology | 493 | 6 | 4 | 4 | 4.6 | O=C(N[C@@](C(=O)N[C@H]1CCCC[C@@H]1O)(Cc1c[nH]c2c1cccc2)C)OC12CC3CC(C2)CC(C1)C3 | 9438020 | |||
| 6604121 | 2105 | None | 24 | Rat | Functional | pIC50 | None | 8.6 | 8.6 | 15848 | 2 | Guide to Pharmacology | 526 | 7 | 2 | 3 | 6.8 | OC(=O)C[C@H](c1cccc2c1cccc2)CC(=O)Nc1c(C)cc(cc1C(=O)N1CCC2(CC1)CCCC2)C | 10204685 | |||
| 909 | 2105 | None | 24 | Rat | Functional | pIC50 | None | 8.6 | 8.6 | 15848 | 2 | Guide to Pharmacology | 526 | 7 | 2 | 3 | 6.8 | OC(=O)C[C@H](c1cccc2c1cccc2)CC(=O)Nc1c(C)cc(cc1C(=O)N1CCC2(CC1)CCCC2)C | 10204685 | |||
| CHEMBL1256717 | 2105 | None | 24 | Rat | Functional | pIC50 | None | 8.6 | 8.6 | 15848 | 2 | Guide to Pharmacology | 526 | 7 | 2 | 3 | 6.8 | OC(=O)C[C@H](c1cccc2c1cccc2)CC(=O)Nc1c(C)cc(cc1C(=O)N1CCC2(CC1)CCCC2)C | 10204685 | |||
| 16129670 | 815 | None | 0 | Human | Functional | pIC50 | None | 8.8 | 8.8 | - | 1 | Guide to Pharmacology | None | None | None | None | 8349705 | |||||
| 860 | 815 | None | 0 | Human | Functional | pIC50 | None | 8.8 | 8.8 | - | 1 | Guide to Pharmacology | None | None | None | None | 8349705 | |||||
| 91898395 | 815 | None | 0 | Human | Functional | pIC50 | None | 8.8 | 8.8 | - | 1 | Guide to Pharmacology | None | None | None | None | 8349705 | |||||
| 108187 | 926 | None | 30 | Mouse | Functional | pIC50 | None | 8.8 | 8.8 | -67 | 5 | Guide to Pharmacology | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 1975695 | |||
| 873 | 926 | None | 30 | Mouse | Functional | pIC50 | None | 8.8 | 8.8 | -67 | 5 | Guide to Pharmacology | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 1975695 | |||
| CHEMBL2062154 | 926 | None | 30 | Mouse | Functional | pIC50 | None | 8.8 | 8.8 | -67 | 5 | Guide to Pharmacology | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 1975695 | |||
| CHEMBL287735 | 926 | None | 30 | Mouse | Functional | pIC50 | None | 8.8 | 8.8 | -67 | 5 | Guide to Pharmacology | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 1975695 | |||
| 122119 | 3023 | None | 0 | Human | Functional | pIC50 | None | 8.9 | 8.9 | 1000 | 2 | Guide to Pharmacology | 618 | 12 | 5 | 6 | 5.1 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](CC1CNc2c1cccc2)(NC(=O)OC1C[C@H]2C([C@]1(C)CC2)(C)C)C)CCC(=O)O | 8914862 | |||
| 882 | 3023 | None | 0 | Human | Functional | pIC50 | None | 8.9 | 8.9 | 1000 | 2 | Guide to Pharmacology | 618 | 12 | 5 | 6 | 5.1 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](CC1CNc2c1cccc2)(NC(=O)OC1C[C@H]2C([C@]1(C)CC2)(C)C)C)CCC(=O)O | 8914862 | |||
| 108187 | 926 | None | 30 | Human | Functional | pIC50 | None | 9.1 | 9.1 | 67 | 5 | Guide to Pharmacology | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 8914862 | |||
| 873 | 926 | None | 30 | Human | Functional | pIC50 | None | 9.1 | 9.1 | 67 | 5 | Guide to Pharmacology | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 8914862 | |||
| CHEMBL2062154 | 926 | None | 30 | Human | Functional | pIC50 | None | 9.1 | 9.1 | 67 | 5 | Guide to Pharmacology | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 8914862 | |||
| CHEMBL287735 | 926 | None | 30 | Human | Functional | pIC50 | None | 9.1 | 9.1 | 67 | 5 | Guide to Pharmacology | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 8914862 | |||
| 5311016 | 592 | None | 0 | Rat | Functional | pIC50 | None | 9.5 | 9.5 | - | 1 | Guide to Pharmacology | None | None | None | None | 14698161 | |||||
| 897 | 592 | None | 0 | Rat | Functional | pIC50 | None | 9.5 | 9.5 | - | 1 | Guide to Pharmacology | None | None | None | None | 14698161 | |||||
| 903 | 3024 | None | 12 | Mouse | Functional | pIC50 | None | 9.8 | 9.8 | 123 | 2 | Guide to Pharmacology | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 8605955 | |||
| 9850711 | 3024 | None | 12 | Mouse | Functional | pIC50 | None | 9.8 | 9.8 | 123 | 2 | Guide to Pharmacology | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 8605955 | |||
| CHEMBL138534 | 3024 | None | 12 | Mouse | Functional | pIC50 | None | 9.8 | 9.8 | 123 | 2 | Guide to Pharmacology | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 8605955 | |||
| CHEMBL2111312 | 3024 | None | 12 | Mouse | Functional | pIC50 | None | 9.8 | 9.8 | 123 | 2 | Guide to Pharmacology | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 8605955 | |||
| 4627 | 822 | None | 42 | Human | Functional | pIC50 | None | 10.0 | 10.0 | -1 | 6 | Guide to Pharmacology | None | None | None | None | 7681836 | |||||
| 4627 | 822 | None | 42 | Human | Functional | pIC50 | None | 10.0 | 10.0 | -1 | 6 | Guide to Pharmacology | None | None | None | None | 8349705 | |||||
| 864 | 822 | None | 42 | Human | Functional | pIC50 | None | 10.0 | 10.0 | -1 | 6 | Guide to Pharmacology | None | None | None | None | 7681836 | |||||
| 864 | 822 | None | 42 | Human | Functional | pIC50 | None | 10.0 | 10.0 | -1 | 6 | Guide to Pharmacology | None | None | None | None | 8349705 | |||||
| 9833444 | 822 | None | 42 | Human | Functional | pIC50 | None | 10.0 | 10.0 | -1 | 6 | Guide to Pharmacology | None | None | None | None | 7681836 | |||||
| 9833444 | 822 | None | 42 | Human | Functional | pIC50 | None | 10.0 | 10.0 | -1 | 6 | Guide to Pharmacology | None | None | None | None | 8349705 | |||||
| CHEMBL1121 | 822 | None | 42 | Human | Functional | pIC50 | None | 10.0 | 10.0 | -1 | 6 | Guide to Pharmacology | None | None | None | None | 7681836 | |||||
| CHEMBL1121 | 822 | None | 42 | Human | Functional | pIC50 | None | 10.0 | 10.0 | -1 | 6 | Guide to Pharmacology | None | None | None | None | 8349705 | |||||
| DB09142 | 822 | None | 42 | Human | Functional | pIC50 | None | 10.0 | 10.0 | -1 | 6 | Guide to Pharmacology | None | None | None | None | 7681836 | |||||
| DB09142 | 822 | None | 42 | Human | Functional | pIC50 | None | 10.0 | 10.0 | -1 | 6 | Guide to Pharmacology | None | None | None | None | 8349705 | |||||
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
| 41684 | 31229 | None | 62 | Human | Binding | pAC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 307 | 4 | 1 | 7 | 2.2 | CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1401 | 31229 | None | 62 | Human | Binding | pAC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 307 | 4 | 1 | 7 | 2.2 | CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 | 10.1038/s41467-023-40064-9 | |||
| 4494 | 190296 | None | 55 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 385 | 5 | 1 | 8 | 2.5 | COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL517427 | 190296 | None | 55 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 385 | 5 | 1 | 8 | 2.5 | COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1 | 10.1038/s41467-023-40064-9 | |||
| 6479523 | 46456 | None | 38 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 461 | 5 | 4 | 6 | 0.1 | CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](NC(=O)N3CCNC3=O)c3ccccc3)C(=O)N2[C@H]1C(=O)O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1537 | 46456 | None | 38 | Human | Binding | pAC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 461 | 5 | 4 | 6 | 0.1 | CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](NC(=O)N3CCNC3=O)c3ccccc3)C(=O)N2[C@H]1C(=O)O | 10.1038/s41467-023-40064-9 | |||
| 6436173 | 55132 | None | 30 | Human | Binding | pAC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 785 | 2 | 5 | 13 | 6.2 | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1617 | 55132 | None | 30 | Human | Binding | pAC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 785 | 2 | 5 | 13 | 6.2 | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C | 10.1038/s41467-023-40064-9 | |||
| 3899 | 210233 | None | 68 | Human | Binding | pAC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 270 | 2 | 1 | 3 | 3.3 | Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL960 | 210233 | None | 68 | Human | Binding | pAC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 270 | 2 | 1 | 3 | 3.3 | Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1 | 10.1038/s41467-023-40064-9 | |||
| 148124 | 209557 | None | 54 | Human | Binding | pAC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 807 | 8 | 5 | 14 | 3.3 | CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL3545252 | 209557 | None | 54 | Human | Binding | pAC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 807 | 8 | 5 | 14 | 3.3 | CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL92 | 209557 | None | 54 | Human | Binding | pAC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 807 | 8 | 5 | 14 | 3.3 | CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C | 10.1038/s41467-023-40064-9 | |||
| 3883 | 183641 | None | 69 | Human | Binding | pAC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 369 | 5 | 1 | 4 | 3.5 | Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL480 | 183641 | None | 69 | Human | Binding | pAC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 369 | 5 | 1 | 4 | 3.5 | Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1 | 10.1038/s41467-023-40064-9 | |||
| 50922675 | 112647 | None | 47 | Human | Binding | pAC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 539 | 9 | 3 | 9 | 3.9 | COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL3301612 | 112647 | None | 47 | Human | Binding | pAC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 539 | 9 | 3 | 9 | 3.9 | COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 | 10.1038/s41467-023-40064-9 | |||
| 228 | 445 | None | 20 | Human | Binding | pAC50 | = | 4.6 | 4.6 | - | 24 | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1038/s41467-023-40064-9 | |||
| 33 | 445 | None | 20 | Human | Binding | pAC50 | = | 4.6 | 4.6 | - | 24 | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1038/s41467-023-40064-9 | |||
| 6005 | 445 | None | 20 | Human | Binding | pAC50 | = | 4.6 | 4.6 | - | 24 | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1038/s41467-023-40064-9 | |||
| 6005.0 | 445 | None | 20 | Human | Binding | pAC50 | = | 4.6 | 4.6 | - | 24 | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL53 | 445 | None | 20 | Human | Binding | pAC50 | = | 4.6 | 4.6 | - | 24 | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1038/s41467-023-40064-9 | |||
| DB00714 | 445 | None | 20 | Human | Binding | pAC50 | = | 4.6 | 4.6 | - | 24 | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1038/s41467-023-40064-9 | |||
| 40973 | 46049 | None | 50 | Human | Binding | pAC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 310 | 1 | 1 | 1 | 4.9 | C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1533 | 46049 | None | 50 | Human | Binding | pAC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 310 | 1 | 1 | 1 | 4.9 | C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC | 10.1038/s41467-023-40064-9 | |||
| 3401 | 78314 | None | 52 | Human | Binding | pAC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 346 | 4 | 0 | 2 | 5.0 | Fc1ccc(C(c2ccccc2)(c2ccccc2F)n2ccnc2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL2107430 | 78314 | None | 52 | Human | Binding | pAC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 346 | 4 | 0 | 2 | 5.0 | Fc1ccc(C(c2ccccc2)(c2ccccc2F)n2ccnc2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 1016 | 3747 | None | 45 | Human | Binding | pAC50 | = | 4.6 | 4.6 | - | 35 | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| 2561 | 3747 | None | 45 | Human | Binding | pAC50 | = | 4.6 | 4.6 | - | 35 | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| 2733526 | 3747 | None | 45 | Human | Binding | pAC50 | = | 4.6 | 4.6 | - | 35 | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| 5384 | 3747 | None | 45 | Human | Binding | pAC50 | = | 4.6 | 4.6 | - | 35 | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL83 | 3747 | None | 45 | Human | Binding | pAC50 | = | 4.6 | 4.6 | - | 35 | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| DB00675 | 3747 | None | 45 | Human | Binding | pAC50 | = | 4.6 | 4.6 | - | 35 | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| 2812 | 4781 | None | 63 | Human | Binding | pAC50 | = | 4.5 | 4.5 | - | 34 | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL104 | 4781 | None | 63 | Human | Binding | pAC50 | = | 4.5 | 4.5 | - | 34 | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | 10.1038/s41467-023-40064-9 | |||
| 104850 | 3330 | None | 58 | Human | Binding | pAC50 | = | 4.5 | 4.5 | - | 6 | ChEMBL | 462 | 4 | 1 | 4 | 5.9 | Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 | 10.1038/s41467-023-40064-9 | |||
| 4150 | 3330 | None | 58 | Human | Binding | pAC50 | = | 4.5 | 4.5 | - | 6 | ChEMBL | 462 | 4 | 1 | 4 | 5.9 | Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 | 10.1038/s41467-023-40064-9 | |||
| 743 | 3330 | None | 58 | Human | Binding | pAC50 | = | 4.5 | 4.5 | - | 6 | ChEMBL | 462 | 4 | 1 | 4 | 5.9 | Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL111 | 3330 | None | 58 | Human | Binding | pAC50 | = | 4.5 | 4.5 | - | 6 | ChEMBL | 462 | 4 | 1 | 4 | 5.9 | Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 | 10.1038/s41467-023-40064-9 | |||
| DB06155 | 3330 | None | 58 | Human | Binding | pAC50 | = | 4.5 | 4.5 | - | 6 | ChEMBL | 462 | 4 | 1 | 4 | 5.9 | Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 | 10.1038/s41467-023-40064-9 | |||
| 2540 | 4402 | None | 68 | Human | Binding | pAC50 | = | 4.5 | 4.5 | - | 4 | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1014 | 4402 | None | 68 | Human | Binding | pAC50 | = | 4.5 | 4.5 | - | 4 | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 3784 | 57188 | None | 67 | Human | Binding | pAC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 371 | 4 | 1 | 8 | 2.6 | COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc2nonc12 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1648 | 57188 | None | 67 | Human | Binding | pAC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 371 | 4 | 1 | 8 | 2.6 | COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc2nonc12 | 10.1038/s41467-023-40064-9 | |||
| 64139 | 84819 | None | 58 | Human | Binding | pAC50 | = | 4.4 | 4.4 | - | 0 | ChEMBL | 315 | 0 | 1 | 2 | 4.1 | O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL223228 | 84819 | None | 58 | Human | Binding | pAC50 | = | 4.4 | 4.4 | - | 0 | ChEMBL | 315 | 0 | 1 | 2 | 4.1 | O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 | 10.1038/s41467-023-40064-9 | |||
| 3380 | 22798 | None | 15 | Human | Binding | pAC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 313 | 2 | 0 | 4 | 2.5 | CN1C(=O)CN=C(c2ccccc2F)c2cc([N+](=O)[O-])ccc21 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL13280 | 22798 | None | 15 | Human | Binding | pAC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 313 | 2 | 0 | 4 | 2.5 | CN1C(=O)CN=C(c2ccccc2F)c2cc([N+](=O)[O-])ccc21 | 10.1038/s41467-023-40064-9 | |||
| 2194 | 63103 | None | 64 | Human | Binding | pAC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 240 | 2 | 0 | 4 | 4.2 | COc1ccc(-c2cc(=S)ss2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL178862 | 63103 | None | 64 | Human | Binding | pAC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 240 | 2 | 0 | 4 | 4.2 | COc1ccc(-c2cc(=S)ss2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 1209 | 1658 | None | 52 | Human | Binding | pAC50 | = | 5.1 | 5.1 | - | 31 | ChEMBL | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | 10.1038/s41467-023-40064-9 | |||
| 203 | 1658 | None | 52 | Human | Binding | pAC50 | = | 5.1 | 5.1 | - | 31 | ChEMBL | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | 10.1038/s41467-023-40064-9 | |||
| 3386 | 1658 | None | 52 | Human | Binding | pAC50 | = | 5.1 | 5.1 | - | 31 | ChEMBL | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | 10.1038/s41467-023-40064-9 | |||
| CHEMBL41 | 1658 | None | 52 | Human | Binding | pAC50 | = | 5.1 | 5.1 | - | 31 | ChEMBL | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | 10.1038/s41467-023-40064-9 | |||
| DB00472 | 1658 | None | 52 | Human | Binding | pAC50 | = | 5.1 | 5.1 | - | 31 | ChEMBL | 309 | 6 | 1 | 2 | 4.4 | CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F | 10.1038/s41467-023-40064-9 | |||
| 10034073 | 17168 | None | 30 | Human | Binding | pAC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 1056 | 13 | 7 | 18 | 6.2 | CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1255800 | 17168 | None | 30 | Human | Binding | pAC50 | = | 5.1 | 5.1 | - | 0 | ChEMBL | 1056 | 13 | 7 | 18 | 6.2 | CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C | 10.1038/s41467-023-40064-9 | |||
| 135564886 | 14499 | None | 5 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
| 135673376 | 14499 | None | 5 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
| 137157436 | 14499 | None | 5 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
| 145948239 | 14499 | None | 5 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
| 71587099 | 14499 | None | 5 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1201304 | 14499 | None | 5 | Human | Binding | pAC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
| 3294 | 2006 | None | 61 | Human | Binding | pAC50 | = | 5.0 | 5.0 | -323 | 44 | ChEMBL | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | 10.1038/s41467-023-40064-9 | |||
| 71360 | 2006 | None | 61 | Human | Binding | pAC50 | = | 5.0 | 5.0 | -323 | 44 | ChEMBL | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | 10.1038/s41467-023-40064-9 | |||
| 71360.0 | 2006 | None | 61 | Human | Binding | pAC50 | = | 5.0 | 5.0 | -323 | 44 | ChEMBL | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | 10.1038/s41467-023-40064-9 | |||
| 87 | 2006 | None | 61 | Human | Binding | pAC50 | = | 5.0 | 5.0 | -323 | 44 | ChEMBL | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL14376 | 2006 | None | 61 | Human | Binding | pAC50 | = | 5.0 | 5.0 | -323 | 44 | ChEMBL | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | 10.1038/s41467-023-40064-9 | |||
| DB04946 | 2006 | None | 61 | Human | Binding | pAC50 | = | 5.0 | 5.0 | -323 | 44 | ChEMBL | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | 10.1038/s41467-023-40064-9 | |||
| 4627 | 822 | None | 42 | Human | Binding | pEC50 | = | 10.3 | 10.3 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm00017a022 | |||||
| 864 | 822 | None | 42 | Human | Binding | pEC50 | = | 10.3 | 10.3 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm00017a022 | |||||
| 9833444 | 822 | None | 42 | Human | Binding | pEC50 | = | 10.3 | 10.3 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm00017a022 | |||||
| CHEMBL1121 | 822 | None | 42 | Human | Binding | pEC50 | = | 10.3 | 10.3 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm00017a022 | |||||
| DB09142 | 822 | None | 42 | Human | Binding | pEC50 | = | 10.3 | 10.3 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm00017a022 | |||||
| 4627 | 822 | None | 42 | Human | Binding | pEC50 | = | 10.0 | 10.0 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/np058114h | |||||
| 864 | 822 | None | 42 | Human | Binding | pEC50 | = | 10.0 | 10.0 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/np058114h | |||||
| 9833444 | 822 | None | 42 | Human | Binding | pEC50 | = | 10.0 | 10.0 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/np058114h | |||||
| CHEMBL1121 | 822 | None | 42 | Human | Binding | pEC50 | = | 10.0 | 10.0 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/np058114h | |||||
| DB09142 | 822 | None | 42 | Human | Binding | pEC50 | = | 10.0 | 10.0 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/np058114h | |||||
| CHEMBL413654 | 215539 | None | 0 | Rat | Binding | pEC50 | = | 6 | 6.0 | 2 | 2 | ChEMBL | None | None | None | CSCC[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/jm00048a016 | |||||
| 10260074 | 106679 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 875 | 25 | 7 | 10 | 3.0 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)N(Cc1ccccc1)N=NCCCl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00048a016 | |||
| CHEMBL3143010 | 106679 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 875 | 25 | 7 | 10 | 3.0 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)N(Cc1ccccc1)N=NCCCl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00048a016 | |||
| 162661486 | 181569 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 5678 | 175 | 68 | 78 | -9.6 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CSC2CC(=O)N(CCC(=O)NC(C(=O)NCCCCCCNC(=O)COCCOCCNC(=O)CCC(NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)CCCCNC(=O)CCN3C(=O)CC(SC[C@H](NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc4c[nH]cn4)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N1)C3=O)C2=O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.0c00736 | |||
| CHEMBL4764500 | 181569 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 5678 | 175 | 68 | 78 | -9.6 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CSC2CC(=O)N(CCC(=O)NC(C(=O)NCCCCCCNC(=O)COCCOCCNC(=O)CCC(NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)CCCCNC(=O)CCN3C(=O)CC(SC[C@H](NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc4c[nH]cn4)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N1)C3=O)C2=O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.0c00736 | |||
| 162661520 | 181635 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 5663 | 173 | 67 | 77 | -8.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc2c[nH]cn2)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)CSC2CC(=O)N(CCC(=O)NCCCCC(C(=O)NCCCCCCNC(=O)COCCOCCNC(=O)CCC(NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)CCN3C(=O)CC(SC[C@@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc4ccc(O)cc4)C(=O)NCC(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(=O)O)NC1=O)C3=O)C2=O | 10.1021/acs.jmedchem.0c00736 | |||
| CHEMBL4765166 | 181635 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 5663 | 173 | 67 | 77 | -8.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc2c[nH]cn2)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)CSC2CC(=O)N(CCC(=O)NCCCCC(C(=O)NCCCCCCNC(=O)COCCOCCNC(=O)CCC(NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)CCN3C(=O)CC(SC[C@@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc4ccc(O)cc4)C(=O)NCC(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(=O)O)NC1=O)C3=O)C2=O | 10.1021/acs.jmedchem.0c00736 | |||
| 10032955 | 168138 | None | 0 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 742 | 17 | 7 | 6 | 5.8 | Cc1ccccc1NC(=O)NCCCC[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)NC(=O)CCC(=O)O | 10.1021/jm00017a022 | |||
| CHEMBL432256 | 168138 | None | 0 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 742 | 17 | 7 | 6 | 5.8 | Cc1ccccc1NC(=O)NCCCC[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)NC(=O)CCC(=O)O | 10.1021/jm00017a022 | |||
| CHEMBL319438 | 213676 | None | 0 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00017a022 | |||||
| 162668747 | 182725 | None | 0 | Human | Binding | pEC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 6123 | 176 | 72 | 84 | -13.9 | CCCCCCCCCCCCCCCC(=O)NCCCCCCNC(=O)C1CCCCNC(=O)CCN2C(=O)CC(SC[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc3c[nH]cn3)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N3CCC[C@H]3C(=O)N3CCC[C@H]3C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)NCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)[C@@H](C)CC)[C@@H](C)CC)CSC3CC(=O)N(CCC(=O)N1)C3=O)C2=O | 10.1021/acs.jmedchem.0c00736 | |||
| CHEMBL4788440 | 182725 | None | 0 | Human | Binding | pEC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 6123 | 176 | 72 | 84 | -13.9 | CCCCCCCCCCCCCCCC(=O)NCCCCCCNC(=O)C1CCCCNC(=O)CCN2C(=O)CC(SC[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc3c[nH]cn3)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N3CCC[C@H]3C(=O)N3CCC[C@H]3C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)NCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)[C@@H](C)CC)[C@@H](C)CC)CSC3CC(=O)N(CCC(=O)N1)C3=O)C2=O | 10.1021/acs.jmedchem.0c00736 | |||
| 162662538 | 182130 | None | 0 | Human | Binding | pEC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 5436 | 173 | 70 | 79 | -19.4 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.0c00736 | |||
| CHEMBL4780789 | 182130 | None | 0 | Human | Binding | pEC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 5436 | 173 | 70 | 79 | -19.4 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.0c00736 | |||
| 162665647 | 182469 | None | 0 | Human | Binding | pEC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 5421 | 171 | 69 | 78 | -18.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.0c00736 | |||
| CHEMBL4784851 | 182469 | None | 0 | Human | Binding | pEC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 5421 | 171 | 69 | 78 | -18.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.0c00736 | |||
| 162665440 | 182366 | None | 0 | Human | Binding | pEC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 5338 | 170 | 70 | 76 | -18.6 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.0c00736 | |||
| CHEMBL4783736 | 182366 | None | 0 | Human | Binding | pEC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 5338 | 170 | 70 | 76 | -18.6 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.0c00736 | |||
| 162673451 | 183295 | None | 0 | Human | Binding | pEC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 6108 | 174 | 71 | 83 | -13.0 | CCCCCCCCCCCCCCCC(=O)NCCCCCCNC(=O)C1CCCCNC(=O)CCN2C(=O)CC(SC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc3c[nH]cn3)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N3CCC[C@H]3C(=O)N3CCC[C@H]3C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)NCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)CSC3CC(=O)N(CCC(=O)N1)C3=O)C2=O | 10.1021/acs.jmedchem.0c00736 | |||
| CHEMBL4795718 | 183295 | None | 0 | Human | Binding | pEC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 6108 | 174 | 71 | 83 | -13.0 | CCCCCCCCCCCCCCCC(=O)NCCCCCCNC(=O)C1CCCCNC(=O)CCN2C(=O)CC(SC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc3c[nH]cn3)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N3CCC[C@H]3C(=O)N3CCC[C@H]3C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)NCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)CSC3CC(=O)N(CCC(=O)N1)C3=O)C2=O | 10.1021/acs.jmedchem.0c00736 | |||
| 90663239 | 106680 | None | 0 | Human | Binding | pEC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 946 | 27 | 8 | 11 | 2.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)CCC(=O)N(Cc1ccccc1)N=NCCCl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00048a016 | |||
| CHEMBL3143011 | 106680 | None | 0 | Human | Binding | pEC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 946 | 27 | 8 | 11 | 2.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)CCC(=O)N(Cc1ccccc1)N=NCCCl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00048a016 | |||
| 162677145 | 183575 | None | 0 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 5323 | 168 | 69 | 75 | -17.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.0c00736 | |||
| CHEMBL4799182 | 183575 | None | 0 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 5323 | 168 | 69 | 75 | -17.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.0c00736 | |||
| 86291008 | 179658 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 4364 | 151 | 59 | 60 | -13.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.0c00736 | |||
| CHEMBL4741697 | 179658 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 4364 | 151 | 59 | 60 | -13.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.0c00736 | |||
| 44348922 | 16248 | None | 0 | Bovine | Binding | pIC50 | = | 10.5 | 10.5 | - | 0 | ChEMBL | 992 | 25 | 11 | 11 | 1.4 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC1CCC[C@H]1NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
| CHEMBL122438 | 16248 | None | 0 | Bovine | Binding | pIC50 | = | 10.5 | 10.5 | - | 0 | ChEMBL | 992 | 25 | 11 | 11 | 1.4 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC1CCC[C@H]1NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
| 880 | 2239 | None | 6 | Human | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | ChEMBL | 487 | 5 | 3 | 7 | 3.5 | O=C(N[C@@H]1N=C(C2CCCCC2)c2c(N(C1=O)C)cccc2)Nc1cccc(c1)N(c1n[nH]nn1)C | 10.1021/jm9506736 | |||
| 9935175 | 2239 | None | 6 | Human | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | ChEMBL | 487 | 5 | 3 | 7 | 3.5 | O=C(N[C@@H]1N=C(C2CCCCC2)c2c(N(C1=O)C)cccc2)Nc1cccc(c1)N(c1n[nH]nn1)C | 10.1021/jm9506736 | |||
| CHEMBL2093059 | 2239 | None | 6 | Human | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | ChEMBL | 487 | 5 | 3 | 7 | 3.5 | O=C(N[C@@H]1N=C(C2CCCCC2)c2c(N(C1=O)C)cccc2)Nc1cccc(c1)N(c1n[nH]nn1)C | 10.1021/jm9506736 | |||
| 10051431 | 121190 | None | 0 | Rat | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 494 | 6 | 2 | 4 | 5.1 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
| CHEMBL357502 | 121190 | None | 0 | Rat | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 494 | 6 | 2 | 4 | 5.1 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
| 10480605 | 78391 | None | 0 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 487 | 5 | 4 | 7 | 3.7 | Cc1ccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)cc1Nc1nn[nH]n1 | 10.1021/jm9506736 | |||
| CHEMBL2110201 | 78391 | None | 0 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 487 | 5 | 4 | 7 | 3.7 | Cc1ccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)cc1Nc1nn[nH]n1 | 10.1021/jm9506736 | |||
| 9916170 | 76581 | None | 5 | Mouse | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 575 | 10 | 4 | 4 | 5.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccc(F)cc1 | 10.1016/s0960-894x(00)00198-0 | |||
| CHEMBL2062146 | 76581 | None | 5 | Mouse | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 575 | 10 | 4 | 4 | 5.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccc(F)cc1 | 10.1016/s0960-894x(00)00198-0 | |||
| 44348850 | 17955 | None | 0 | Bovine | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 986 | 24 | 11 | 11 | 2.0 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
| CHEMBL126008 | 17955 | None | 0 | Bovine | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 986 | 24 | 11 | 11 | 2.0 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
| 9960703 | 168141 | None | 0 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 621 | 6 | 3 | 7 | 4.0 | O=C(Nc1cccc(-c2nn[nH]n2)c1)NC1N=C(c2ccccc2F)c2ccccc2N(CC(=O)N2CC3CCC(CC3)C2)C1=O | 10.1016/s0960-894x(98)00237-6 | |||
| CHEMBL432266 | 168141 | None | 0 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 621 | 6 | 3 | 7 | 4.0 | O=C(Nc1cccc(-c2nn[nH]n2)c1)NC1N=C(c2ccccc2F)c2ccccc2N(CC(=O)N2CC3CCC(CC3)C2)C1=O | 10.1016/s0960-894x(98)00237-6 | |||
| 9872735 | 187133 | None | 0 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 567 | 5 | 2 | 4 | 5.1 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3ccccc3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 | 10.1016/S0960-894X(96)00609-9 | |||
| CHEMBL49085 | 187133 | None | 0 | Human | Binding | pIC50 | = | 10.1 | 10.1 | - | 0 | ChEMBL | 567 | 5 | 2 | 4 | 5.1 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3ccccc3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 | 10.1016/S0960-894X(96)00609-9 | |||
| 155559320 | 174968 | None | 0 | Human | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 1872 | 72 | 18 | 23 | 3.8 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4563364 | 174968 | None | 0 | Human | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 1872 | 72 | 18 | 23 | 3.8 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 21842340 | 44104 | None | 0 | Rat | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 508 | 6 | 2 | 4 | 5.5 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3(C)CCCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
| CHEMBL151483 | 44104 | None | 0 | Rat | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 508 | 6 | 2 | 4 | 5.5 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3(C)CCCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
| 132980 | 2240 | None | 13 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 | 10.1021/jm00032a002 | |||
| 881 | 2240 | None | 13 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 | 10.1021/jm00032a002 | |||
| CHEMBL420783 | 2240 | None | 13 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 | 10.1021/jm00032a002 | |||
| 9828961 | 168089 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 548 | 6 | 4 | 4 | 5.2 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)O)c1)C[C@@H]2C1CCCCC1 | 10.1016/0960-894X(95)00327-P | |||
| CHEMBL431919 | 168089 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 548 | 6 | 4 | 4 | 5.2 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)O)c1)C[C@@H]2C1CCCCC1 | 10.1016/0960-894X(95)00327-P | |||
| 132980 | 2240 | None | 13 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 | 10.1016/0960-894X(95)00530-0 | |||
| 881 | 2240 | None | 13 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 | 10.1016/0960-894X(95)00530-0 | |||
| CHEMBL420783 | 2240 | None | 13 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 | 10.1016/0960-894X(95)00530-0 | |||
| 21842392 | 166804 | None | 24 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1039/C7MD00171A | |||
| CHEMBL4282712 | 166804 | None | 24 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1039/C7MD00171A | |||
| 132980 | 2240 | None | 13 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 | 10.1021/jm9608523 | |||
| 881 | 2240 | None | 13 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 | 10.1021/jm9608523 | |||
| CHEMBL420783 | 2240 | None | 13 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 | 10.1021/jm9608523 | |||
| 887 | 4110 | None | 30 | Rat | Binding | pIC50 | = | 10 | 10.0 | 1 | 4 | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm960669+ | |||
| 9870520 | 4110 | None | 30 | Rat | Binding | pIC50 | = | 10 | 10.0 | 1 | 4 | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm960669+ | |||
| 9870520.0 | 4110 | None | 30 | Rat | Binding | pIC50 | = | 10 | 10.0 | 1 | 4 | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm960669+ | |||
| CHEMBL324547 | 4110 | None | 30 | Rat | Binding | pIC50 | = | 10 | 10.0 | 1 | 4 | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm960669+ | |||
| DB12355 | 4110 | None | 30 | Rat | Binding | pIC50 | = | 10 | 10.0 | 1 | 4 | ChEMBL | 498 | 6 | 3 | 6 | 4.1 | CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 | 10.1021/jm960669+ | |||
| 122130 | 4115 | None | 31 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 1 | ChEMBL | 516 | 6 | 2 | 4 | 5.5 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 | 10.1016/0960-894X(95)00556-9 | |||
| 888 | 4115 | None | 31 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 1 | ChEMBL | 516 | 6 | 2 | 4 | 5.5 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 | 10.1016/0960-894X(95)00556-9 | |||
| CHEMBL115121 | 4115 | None | 31 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 1 | ChEMBL | 516 | 6 | 2 | 4 | 5.5 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 | 10.1016/0960-894X(95)00556-9 | |||
| 3452843 | 119589 | None | 6 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 10 | ChEMBL | 516 | 6 | 2 | 4 | 5.5 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
| CHEMBL345686 | 119589 | None | 6 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 10 | ChEMBL | 516 | 6 | 2 | 4 | 5.5 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
| 10323431 | 57769 | None | 0 | Human | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 493 | 4 | 3 | 7 | 2.9 | CN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)N(c2nn[nH]n2)CC3)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm9506736 | |||
| CHEMBL166941 | 57769 | None | 0 | Human | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 493 | 4 | 3 | 7 | 2.9 | CN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)N(c2nn[nH]n2)CC3)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm9506736 | |||
| 122130 | 4115 | None | 31 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 1 | ChEMBL | 516 | 6 | 2 | 4 | 5.5 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 | 10.1021/jm960669+ | |||
| 888 | 4115 | None | 31 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 1 | ChEMBL | 516 | 6 | 2 | 4 | 5.5 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 | 10.1021/jm960669+ | |||
| CHEMBL115121 | 4115 | None | 31 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 1 | ChEMBL | 516 | 6 | 2 | 4 | 5.5 | Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 | 10.1021/jm960669+ | |||
| 24039375 | 9889 | None | 0 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 540 | 8 | 2 | 6 | 4.9 | CCN(CC)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
| CHEMBL114277 | 9889 | None | 0 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 540 | 8 | 2 | 6 | 4.9 | CCN(CC)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
| 9850184 | 110934 | None | 0 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 538 | 6 | 2 | 6 | 4.6 | CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N3CCCC3)c2)N=C(c2ccccn2)c2ccccc21 | 10.1021/jm960669+ | |||
| CHEMBL326102 | 110934 | None | 0 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 538 | 6 | 2 | 6 | 4.6 | CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N3CCCC3)c2)N=C(c2ccccn2)c2ccccc21 | 10.1021/jm960669+ | |||
| 23844129 | 113563 | None | 0 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 497 | 6 | 3 | 5 | 4.7 | CNc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
| CHEMBL332024 | 113563 | None | 0 | Rat | Binding | pIC50 | = | 10.0 | 10.0 | - | 0 | ChEMBL | 497 | 6 | 3 | 5 | 4.7 | CNc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
| 21842325 | 120186 | None | 0 | Rat | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 495 | 6 | 2 | 5 | 4.5 | Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
| CHEMBL351144 | 120186 | None | 0 | Rat | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 495 | 6 | 2 | 5 | 4.5 | Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
| 4627 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.9 | 9.9 | -1 | 5 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.03.006 | |||||
| 864 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.9 | 9.9 | -1 | 5 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.03.006 | |||||
| 9833444 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.9 | 9.9 | -1 | 5 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.03.006 | |||||
| CHEMBL1121 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.9 | 9.9 | -1 | 5 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.03.006 | |||||
| DB09142 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.9 | 9.9 | -1 | 5 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.03.006 | |||||
| 4627 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.9 | 9.9 | -1 | 5 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
| 864 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.9 | 9.9 | -1 | 5 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
| 9833444 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.9 | 9.9 | -1 | 5 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
| CHEMBL1121 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.9 | 9.9 | -1 | 5 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
| DB09142 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.9 | 9.9 | -1 | 5 | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | |||||
| 10006792 | 44939 | None | 0 | Rat | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 517 | 6 | 2 | 5 | 4.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
| CHEMBL152306 | 44939 | None | 0 | Rat | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 517 | 6 | 2 | 5 | 4.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
| 155543846 | 173315 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 1838 | 72 | 19 | 24 | 2.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4522865 | 173315 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 1838 | 72 | 19 | 24 | 2.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 155546692 | 173746 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 1861 | 72 | 19 | 23 | 3.2 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4534236 | 173746 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 1861 | 72 | 19 | 23 | 3.2 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 108187 | 926 | None | 30 | Human | Binding | pIC50 | = | 9.9 | 9.9 | -4 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm00017a022 | |||
| 873 | 926 | None | 30 | Human | Binding | pIC50 | = | 9.9 | 9.9 | -4 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm00017a022 | |||
| CHEMBL2062154 | 926 | None | 30 | Human | Binding | pIC50 | = | 9.9 | 9.9 | -4 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm00017a022 | |||
| CHEMBL287735 | 926 | None | 30 | Human | Binding | pIC50 | = | 9.9 | 9.9 | -4 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm00017a022 | |||
| 23757281 | 9853 | None | 0 | Rat | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 539 | 8 | 2 | 5 | 5.5 | CCN(CC)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
| CHEMBL114072 | 9853 | None | 0 | Rat | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 539 | 8 | 2 | 5 | 5.5 | CCN(CC)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
| 44376113 | 120025 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 494 | 6 | 3 | 6 | 3.9 | CC(C)CN1C(=O)[C@@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00032a003 | |||
| CHEMBL349730 | 120025 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 494 | 6 | 3 | 6 | 3.9 | CC(C)CN1C(=O)[C@@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00032a003 | |||
| 903 | 3024 | None | 12 | Mouse | Binding | pIC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(00)80273-5 | |||
| 9850711 | 3024 | None | 12 | Mouse | Binding | pIC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(00)80273-5 | |||
| CHEMBL138534 | 3024 | None | 12 | Mouse | Binding | pIC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(00)80273-5 | |||
| CHEMBL2111312 | 3024 | None | 12 | Mouse | Binding | pIC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(00)80273-5 | |||
| 903 | 3024 | None | 12 | Mouse | Binding | pIC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm000937a | |||
| 9850711 | 3024 | None | 12 | Mouse | Binding | pIC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm000937a | |||
| CHEMBL138534 | 3024 | None | 12 | Mouse | Binding | pIC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm000937a | |||
| CHEMBL2111312 | 3024 | None | 12 | Mouse | Binding | pIC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm000937a | |||
| 904 | 3026 | None | 12 | Mouse | Binding | pIC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(01)80769-1 | |||
| 9915756 | 3026 | None | 12 | Mouse | Binding | pIC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(01)80769-1 | |||
| CHEMBL2111204 | 3026 | None | 12 | Mouse | Binding | pIC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(01)80769-1 | |||
| CHEMBL356898 | 3026 | None | 12 | Mouse | Binding | pIC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(01)80769-1 | |||
| 903 | 3024 | None | 12 | Mouse | Binding | pIC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
| 9850711 | 3024 | None | 12 | Mouse | Binding | pIC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
| CHEMBL138534 | 3024 | None | 12 | Mouse | Binding | pIC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
| CHEMBL2111312 | 3024 | None | 12 | Mouse | Binding | pIC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
| 903 | 3024 | None | 12 | Mouse | Binding | pIC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm970065l | |||
| 9850711 | 3024 | None | 12 | Mouse | Binding | pIC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm970065l | |||
| CHEMBL138534 | 3024 | None | 12 | Mouse | Binding | pIC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm970065l | |||
| CHEMBL2111312 | 3024 | None | 12 | Mouse | Binding | pIC50 | = | 9.8 | 9.8 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm970065l | |||
| 155558199 | 174873 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 1894 | 75 | 19 | 24 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4561184 | 174873 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 1894 | 75 | 19 | 24 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 155533399 | 171948 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 1838 | 72 | 19 | 24 | 1.4 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4468861 | 171948 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 1838 | 72 | 19 | 24 | 1.4 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 10744359 | 10159 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 513 | 6 | 2 | 6 | 4.5 | CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc([N+](=O)[O-])c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm960669+ | |||
| CHEMBL115833 | 10159 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 513 | 6 | 2 | 6 | 4.5 | CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc([N+](=O)[O-])c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm960669+ | |||
| 155544674 | 175040 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 1822 | 71 | 18 | 23 | 2.5 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4565336 | 175040 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 1822 | 71 | 18 | 23 | 2.5 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 15291593 | 112915 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 537 | 6 | 2 | 5 | 5.2 | CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N3CCCC3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm960669+ | |||
| CHEMBL330933 | 112915 | None | 0 | Rat | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 537 | 6 | 2 | 5 | 5.2 | CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N3CCCC3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm960669+ | |||
| 9828961 | 168089 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 548 | 6 | 4 | 4 | 5.2 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)O)c1)C[C@@H]2C1CCCCC1 | 10.1016/0960-894X(95)00327-P | |||
| CHEMBL431919 | 168089 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 548 | 6 | 4 | 4 | 5.2 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)O)c1)C[C@@H]2C1CCCCC1 | 10.1016/0960-894X(95)00327-P | |||
| 11798691 | 58288 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 473 | 5 | 4 | 7 | 3.4 | CN1C(=O)[C@H](NC(=O)Nc2cccc(Nc3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm9506736 | |||
| CHEMBL168263 | 58288 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 473 | 5 | 4 | 7 | 3.4 | CN1C(=O)[C@H](NC(=O)Nc2cccc(Nc3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm9506736 | |||
| CHEMBL384035 | 214776 | None | 3 | Human | Binding | pIC50 | = | 9.7 | 9.7 | 8 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00072a024 | |||||
| CHEMBL428666 | 214776 | None | 3 | Human | Binding | pIC50 | = | 9.7 | 9.7 | 8 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00072a024 | |||||
| 10839478 | 110720 | None | 1 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 512 | 6 | 2 | 6 | 4.1 | CN(C)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
| CHEMBL325863 | 110720 | None | 1 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 512 | 6 | 2 | 6 | 4.1 | CN(C)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
| 145993882 | 167432 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 509 | 5 | 4 | 6 | 4.2 | O=C(O)c1cccc(NC(=S)NNc2nc3ccccc3c(=O)n2-c2ccc(Br)cc2)c1 | 10.1039/C7MD00171A | |||
| CHEMBL4294388 | 167432 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 509 | 5 | 4 | 6 | 4.2 | O=C(O)c1cccc(NC(=S)NNc2nc3ccccc3c(=O)n2-c2ccc(Br)cc2)c1 | 10.1039/C7MD00171A | |||
| 155516677 | 170192 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 1822 | 72 | 18 | 23 | 2.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4443415 | 170192 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 1822 | 72 | 18 | 23 | 2.7 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 44368611 | 122060 | None | 0 | Mouse | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 541 | 10 | 4 | 3 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL359292 | 122060 | None | 0 | Mouse | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 541 | 10 | 4 | 3 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| 23928173 | 114212 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 511 | 6 | 2 | 5 | 4.7 | CN(C)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
| CHEMBL332931 | 114212 | None | 0 | Rat | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 511 | 6 | 2 | 5 | 4.7 | CN(C)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
| CHEMBL382409 | 214766 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | 6918 | 2 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
| 44300743 | 101014 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 572 | 6 | 4 | 6 | 4.7 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2C1CCCCC1 | 10.1016/0960-894X(95)00327-P | |||
| CHEMBL294161 | 101014 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 572 | 6 | 4 | 6 | 4.7 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2C1CCCCC1 | 10.1016/0960-894X(95)00327-P | |||
| 10459108 | 28417 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 513 | 8 | 2 | 5 | 3.9 | CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| CHEMBL137516 | 28417 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 513 | 8 | 2 | 5 | 3.9 | CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| 4627 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.6 | 9.6 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm960249k | |||||
| 864 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.6 | 9.6 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm960249k | |||||
| 9833444 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.6 | 9.6 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm960249k | |||||
| CHEMBL1121 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.6 | 9.6 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm960249k | |||||
| DB09142 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.6 | 9.6 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm960249k | |||||
| 21842375 | 44284 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 494 | 6 | 2 | 4 | 5.1 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
| CHEMBL151719 | 44284 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 494 | 6 | 2 | 4 | 5.1 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
| 21842375 | 44284 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 494 | 6 | 2 | 4 | 5.1 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
| CHEMBL151719 | 44284 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 494 | 6 | 2 | 4 | 5.1 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
| 44313549 | 207300 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 573 | 6 | 3 | 6 | 4.3 | CN1C(=O)C(NC(=O)Nc2cccc(S(=O)(=O)NC(=O)c3ccccc3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1016/0960-894X(95)00399-E | |||
| CHEMBL75490 | 207300 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 573 | 6 | 3 | 6 | 4.3 | CN1C(=O)C(NC(=O)Nc2cccc(S(=O)(=O)NC(=O)c3ccccc3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1016/0960-894X(95)00399-E | |||
| 10440992 | 161390 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 990 | 28 | 9 | 11 | 1.8 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
| CHEMBL412238 | 161390 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 990 | 28 | 9 | 11 | 1.8 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
| 10075097 | 28652 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 511 | 6 | 2 | 5 | 3.6 | COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1021/jm00078a018 | |||
| CHEMBL137726 | 28652 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 511 | 6 | 2 | 5 | 3.6 | COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1021/jm00078a018 | |||
| 44331825 | 168076 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 692 | 5 | 1 | 6 | 5.1 | CC(C)(C)OC(=O)N1c2ccccc2C[C@@H]1C(=O)N1[C@H](c2ccccc2)CC[C@@H]1C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1CCCC1C(=O)O | 10.1016/S0960-894X(96)00546-X | |||
| CHEMBL431805 | 168076 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 692 | 5 | 1 | 6 | 5.1 | CC(C)(C)OC(=O)N1c2ccccc2C[C@@H]1C(=O)N1[C@H](c2ccccc2)CC[C@@H]1C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1CCCC1C(=O)O | 10.1016/S0960-894X(96)00546-X | |||
| 44300989 | 101034 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 625 | 7 | 4 | 6 | 4.2 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(C)(=O)=O)c1)C[C@@H]2C1CCCCC1 | 10.1016/0960-894X(95)00327-P | |||
| CHEMBL294252 | 101034 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 625 | 7 | 4 | 6 | 4.2 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(C)(=O)=O)c1)C[C@@H]2C1CCCCC1 | 10.1016/0960-894X(95)00327-P | |||
| 136055865 | 120260 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 468 | 4 | 3 | 7 | 3.4 | CN1C(=O)[C@@H](NC(=O)Nc2ccc(-c3noc(O)n3)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00032a003 | |||
| CHEMBL351891 | 120260 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 468 | 4 | 3 | 7 | 3.4 | CN1C(=O)[C@@H](NC(=O)Nc2ccc(-c3noc(O)n3)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00032a003 | |||
| 10257790 | 102910 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 587 | 6 | 3 | 6 | 4.6 | Cc1ccccc1S(=O)(=O)NC(=O)c1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/0960-894X(95)00399-E | |||
| CHEMBL305649 | 102910 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 587 | 6 | 3 | 6 | 4.6 | Cc1ccccc1S(=O)(=O)NC(=O)c1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/0960-894X(95)00399-E | |||
| 21842331 | 43552 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 522 | 7 | 2 | 4 | 5.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)CC3CCCCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
| CHEMBL150869 | 43552 | None | 0 | Rat | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 522 | 7 | 2 | 4 | 5.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)CC3CCCCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
| 10414170 | 170721 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 515 | 5 | 2 | 4 | 4.3 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1016/S0960-894X(00)80683-6 | |||
| CHEMBL445095 | 170721 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 515 | 5 | 2 | 4 | 4.3 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1016/S0960-894X(00)80683-6 | |||
| 9953071 | 201521 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 404 | 3 | 2 | 3 | 4.5 | Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
| CHEMBL58699 | 201521 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 404 | 3 | 2 | 3 | 4.5 | Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
| 9953071 | 201521 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 404 | 3 | 2 | 3 | 4.5 | Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/0960-894X(95)00399-E | |||
| CHEMBL58699 | 201521 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 404 | 3 | 2 | 3 | 4.5 | Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/0960-894X(95)00399-E | |||
| 10414170 | 170721 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 515 | 5 | 2 | 4 | 4.3 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1021/jm00121a004 | |||
| CHEMBL445095 | 170721 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 515 | 5 | 2 | 4 | 4.3 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1021/jm00121a004 | |||
| 9953071 | 201521 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 404 | 3 | 2 | 3 | 4.5 | Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(01)80987-2 | |||
| CHEMBL58699 | 201521 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 404 | 3 | 2 | 3 | 4.5 | Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(01)80987-2 | |||
| 10719765 | 78392 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 487 | 6 | 4 | 7 | 3.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CNc3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm9506736 | |||
| CHEMBL2110202 | 78392 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 487 | 6 | 4 | 7 | 3.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CNc3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1021/jm9506736 | |||
| 9953071 | 201521 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 404 | 3 | 2 | 3 | 4.5 | Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm9608523 | |||
| CHEMBL58699 | 201521 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 404 | 3 | 2 | 3 | 4.5 | Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm9608523 | |||
| 4627 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | |||||
| 864 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | |||||
| 9833444 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | |||||
| CHEMBL1121 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | |||||
| DB09142 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b01558 | |||||
| 155555346 | 174476 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 1836 | 71 | 17 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4551834 | 174476 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 1836 | 71 | 17 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL384035 | 214776 | None | 3 | Human | Binding | pIC50 | = | 9.5 | 9.5 | 8 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80679-4 | |||||
| CHEMBL428666 | 214776 | None | 3 | Human | Binding | pIC50 | = | 9.5 | 9.5 | 8 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80679-4 | |||||
| CHEMBL384035 | 214776 | None | 3 | Human | Binding | pIC50 | = | 9.5 | 9.5 | 8 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00072a024 | |||||
| CHEMBL428666 | 214776 | None | 3 | Human | Binding | pIC50 | = | 9.5 | 9.5 | 8 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00072a024 | |||||
| 4627 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 5 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(00)00198-0 | |||||
| 864 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 5 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(00)00198-0 | |||||
| 9833444 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 5 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(00)00198-0 | |||||
| CHEMBL1121 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 5 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(00)00198-0 | |||||
| DB09142 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 5 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(00)00198-0 | |||||
| 18957789 | 207304 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 539 | 6 | 3 | 6 | 3.6 | CC(C)S(=O)(=O)NC(=O)c1cccc(NC(=O)NC2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/0960-894X(95)00399-E | |||
| CHEMBL75536 | 207304 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 539 | 6 | 3 | 6 | 3.6 | CC(C)S(=O)(=O)NC(=O)c1cccc(NC(=O)NC2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/0960-894X(95)00399-E | |||
| 71460027 | 79746 | None | 0 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 541 | 9 | 4 | 4 | 5.3 | O=C(O)C[C@H](Cc1ccccc1)NC(=O)C(=Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1016/S0960-894X(00)80273-5 | |||
| CHEMBL2115544 | 79746 | None | 0 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 541 | 9 | 4 | 4 | 5.3 | O=C(O)C[C@H](Cc1ccccc1)NC(=O)C(=Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1016/S0960-894X(00)80273-5 | |||
| CHEMBL269098 | 213237 | None | 0 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(01)81250-6 | |||||
| 4627 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 5 | ChEMBL | None | None | None | None | 10.1021/jm00092a007 | |||||
| 864 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 5 | ChEMBL | None | None | None | None | 10.1021/jm00092a007 | |||||
| 9833444 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 5 | ChEMBL | None | None | None | None | 10.1021/jm00092a007 | |||||
| CHEMBL1121 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 5 | ChEMBL | None | None | None | None | 10.1021/jm00092a007 | |||||
| DB09142 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 5 | ChEMBL | None | None | None | None | 10.1021/jm00092a007 | |||||
| 15667003 | 97392 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 1016 | 27 | 8 | 11 | 2.3 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC(CCC)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
| CHEMBL269355 | 97392 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 1016 | 27 | 8 | 11 | 2.3 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC(CCC)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
| 4627 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 5 | ChEMBL | None | None | None | None | 10.1021/jm00105a062 | |||||
| 864 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 5 | ChEMBL | None | None | None | None | 10.1021/jm00105a062 | |||||
| 9833444 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 5 | ChEMBL | None | None | None | None | 10.1021/jm00105a062 | |||||
| CHEMBL1121 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 5 | ChEMBL | None | None | None | None | 10.1021/jm00105a062 | |||||
| DB09142 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 5 | ChEMBL | None | None | None | None | 10.1021/jm00105a062 | |||||
| 10673039 | 58281 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 501 | 5 | 3 | 7 | 3.8 | Cc1ccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)cc1N(C)c1nn[nH]n1 | 10.1021/jm9506736 | |||
| CHEMBL168253 | 58281 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 501 | 5 | 3 | 7 | 3.8 | Cc1ccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)cc1N(C)c1nn[nH]n1 | 10.1021/jm9506736 | |||
| 4627 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 5 | ChEMBL | None | None | None | None | 10.1016/S0960-894X(00)80687-3 | |||||
| 864 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 5 | ChEMBL | None | None | None | None | 10.1016/S0960-894X(00)80687-3 | |||||
| 9833444 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 5 | ChEMBL | None | None | None | None | 10.1016/S0960-894X(00)80687-3 | |||||
| CHEMBL1121 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 5 | ChEMBL | None | None | None | None | 10.1016/S0960-894X(00)80687-3 | |||||
| DB09142 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 5 | ChEMBL | None | None | None | None | 10.1016/S0960-894X(00)80687-3 | |||||
| 4627 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 5 | ChEMBL | None | None | None | None | 10.1021/jm00057a005 | |||||
| 864 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 5 | ChEMBL | None | None | None | None | 10.1021/jm00057a005 | |||||
| 9833444 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 5 | ChEMBL | None | None | None | None | 10.1021/jm00057a005 | |||||
| CHEMBL1121 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 5 | ChEMBL | None | None | None | None | 10.1021/jm00057a005 | |||||
| DB09142 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 5 | ChEMBL | None | None | None | None | 10.1021/jm00057a005 | |||||
| 4627 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm9601664 | |||||
| 864 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm9601664 | |||||
| 9833444 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm9601664 | |||||
| CHEMBL1121 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm9601664 | |||||
| DB09142 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm9601664 | |||||
| 4627 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm950626d | |||||
| 864 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm950626d | |||||
| 9833444 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm950626d | |||||
| CHEMBL1121 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm950626d | |||||
| DB09142 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm950626d | |||||
| 4627 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm00001a027 | |||||
| 864 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm00001a027 | |||||
| 9833444 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm00001a027 | |||||
| CHEMBL1121 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm00001a027 | |||||
| DB09142 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm00001a027 | |||||
| 4627 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm00017a022 | |||||
| 864 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm00017a022 | |||||
| 9833444 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm00017a022 | |||||
| CHEMBL1121 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm00017a022 | |||||
| DB09142 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm00017a022 | |||||
| 4627 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)00062-0 | |||||
| 864 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)00062-0 | |||||
| 9833444 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)00062-0 | |||||
| CHEMBL1121 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)00062-0 | |||||
| DB09142 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1016/S0960-894X(97)00062-0 | |||||
| 10074366 | 120662 | None | 0 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL3349028 | 120662 | None | 0 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL3545866 | 120662 | None | 0 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| 4627 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm960205b | |||||
| 864 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm960205b | |||||
| 9833444 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm960205b | |||||
| CHEMBL1121 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm960205b | |||||
| DB09142 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm960205b | |||||
| 4627 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm970265x | |||||
| 864 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm970265x | |||||
| 9833444 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm970265x | |||||
| CHEMBL1121 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm970265x | |||||
| DB09142 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.5 | 9.5 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm970265x | |||||
| 44210536 | 169464 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 511 | 5 | 3 | 6 | 3.0 | CC(=O)NS(=O)(=O)c1cccc(NC(=O)NC2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/0960-894X(95)00399-E | |||
| CHEMBL441989 | 169464 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 511 | 5 | 3 | 6 | 3.0 | CC(=O)NS(=O)(=O)c1cccc(NC(=O)NC2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/0960-894X(95)00399-E | |||
| 44293892 | 161781 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 613 | 6 | 2 | 5 | 5.8 | CSc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 | 10.1016/S0960-894X(96)00609-9 | |||
| CHEMBL413267 | 161781 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 613 | 6 | 2 | 5 | 5.8 | CSc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 | 10.1016/S0960-894X(96)00609-9 | |||
| 9892971 | 121061 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 522 | 6 | 2 | 4 | 5.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3(C)CCCCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
| CHEMBL356386 | 121061 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 522 | 6 | 2 | 4 | 5.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3(C)CCCCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
| 10484212 | 99933 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 635 | 6 | 3 | 7 | 4.3 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F | 10.1016/S0960-894X(96)00609-9 | |||
| CHEMBL285921 | 99933 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 635 | 6 | 3 | 7 | 4.3 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F | 10.1016/S0960-894X(96)00609-9 | |||
| 155564367 | 175260 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 1836 | 72 | 18 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4570130 | 175260 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 1836 | 72 | 18 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 21842313 | 168658 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 508 | 6 | 2 | 4 | 5.5 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
| CHEMBL435639 | 168658 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 508 | 6 | 2 | 4 | 5.5 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
| 162659624 | 181342 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 1449 | 38 | 15 | 19 | -1.6 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/acs.jmedchem.0c01233 | |||
| CHEMBL4761587 | 181342 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 1449 | 38 | 15 | 19 | -1.6 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/acs.jmedchem.0c01233 | |||
| 21842373 | 121044 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 480 | 6 | 2 | 4 | 4.7 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3(C)CC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
| CHEMBL356226 | 121044 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 480 | 6 | 2 | 4 | 4.7 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3(C)CC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
| 23844130 | 10116 | None | 18 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 484 | 5 | 3 | 6 | 3.6 | CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N)c2)N=C(c2ccccn2)c2ccccc21 | 10.1021/jm960669+ | |||
| CHEMBL115612 | 10116 | None | 18 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 484 | 5 | 3 | 6 | 3.6 | CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N)c2)N=C(c2ccccn2)c2ccccc21 | 10.1021/jm960669+ | |||
| 9982757 | 51486 | None | 1 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 483 | 5 | 2 | 5 | 4.3 | Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
| CHEMBL158235 | 51486 | None | 1 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 483 | 5 | 2 | 5 | 4.3 | Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
| 9891461 | 165117 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 483 | 5 | 2 | 5 | 4.3 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
| CHEMBL422604 | 165117 | None | 0 | Rat | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 483 | 5 | 2 | 5 | 4.3 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
| CHEMBL37830 | 214720 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | None | None | None | CCCS[C@@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00001a019 | |||||
| 44293810 | 101808 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 581 | 5 | 2 | 4 | 5.4 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 | 10.1016/S0960-894X(96)00609-9 | |||
| CHEMBL299800 | 101808 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 581 | 5 | 2 | 4 | 5.4 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 | 10.1016/S0960-894X(96)00609-9 | |||
| 10369805 | 100606 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 532 | 5 | 3 | 3 | 5.6 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
| CHEMBL291458 | 100606 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 532 | 5 | 3 | 3 | 5.6 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
| 10369805 | 100606 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 532 | 5 | 3 | 3 | 5.6 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 | 10.1021/jm00048a015 | |||
| CHEMBL291458 | 100606 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 532 | 5 | 3 | 3 | 5.6 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 | 10.1021/jm00048a015 | |||
| 44348650 | 113169 | None | 0 | Bovine | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 986 | 24 | 11 | 11 | 2.0 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cccc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
| CHEMBL331408 | 113169 | None | 0 | Bovine | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 986 | 24 | 11 | 11 | 2.0 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cccc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
| 10414170 | 170721 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 515 | 5 | 2 | 4 | 4.3 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1016/S0960-894X(00)80683-6 | |||
| CHEMBL445095 | 170721 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 515 | 5 | 2 | 4 | 4.3 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1016/S0960-894X(00)80683-6 | |||
| 10414170 | 170721 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 515 | 5 | 2 | 4 | 4.3 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1021/jm00121a004 | |||
| CHEMBL445095 | 170721 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 515 | 5 | 2 | 4 | 4.3 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1021/jm00121a004 | |||
| 15666988 | 107315 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 976 | 29 | 10 | 11 | 1.6 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
| CHEMBL316949 | 107315 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 976 | 29 | 10 | 11 | 1.6 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
| 14888718 | 77281 | None | 0 | Bovine | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 1041 | 29 | 11 | 14 | -0.1 | CSCC[C@H](NC(=O)[C@H](Cc1ccc(-c2nn[nH]n2)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
| CHEMBL2079606 | 77281 | None | 0 | Bovine | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 1041 | 29 | 11 | 14 | -0.1 | CSCC[C@H](NC(=O)[C@H](Cc1ccc(-c2nn[nH]n2)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
| 23815458 | 167898 | None | 1 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 483 | 5 | 3 | 5 | 4.2 | CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm960669+ | |||
| CHEMBL430516 | 167898 | None | 1 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 483 | 5 | 3 | 5 | 4.2 | CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm960669+ | |||
| 903 | 3024 | None | 12 | Mouse | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| 9850711 | 3024 | None | 12 | Mouse | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL138534 | 3024 | None | 12 | Mouse | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL2111312 | 3024 | None | 12 | Mouse | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| 21842317 | 121745 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 482 | 5 | 2 | 4 | 4.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
| CHEMBL358646 | 121745 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 482 | 5 | 2 | 4 | 4.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
| 21842317 | 121745 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 482 | 5 | 2 | 4 | 4.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
| CHEMBL358646 | 121745 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 482 | 5 | 2 | 4 | 4.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
| 10322988 | 10150 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 482 | 5 | 2 | 4 | 4.9 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
| CHEMBL115772 | 10150 | None | 0 | Rat | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 482 | 5 | 2 | 4 | 4.9 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
| 10478703 | 119976 | None | 1 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(NC(=O)NC2N=C(N3CC4CCC(CC4)C3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
| CHEMBL349291 | 119976 | None | 1 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(NC(=O)NC2N=C(N3CC4CCC(CC4)C3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
| 10323637 | 106242 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 498 | 7 | 2 | 5 | 3.6 | CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccn2)c2ccccc21 | 10.1021/jm00078a018 | |||
| CHEMBL313813 | 106242 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 498 | 7 | 2 | 5 | 3.6 | CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccn2)c2ccccc21 | 10.1021/jm00078a018 | |||
| 10323637 | 106242 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 498 | 7 | 2 | 5 | 3.6 | CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccn2)c2ccccc21 | 10.1021/jm9608523 | |||
| CHEMBL313813 | 106242 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 498 | 7 | 2 | 5 | 3.6 | CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccn2)c2ccccc21 | 10.1021/jm9608523 | |||
| 21842400 | 121038 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 496 | 7 | 2 | 4 | 5.3 | CCC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/0960-894X(95)00556-9 | |||
| CHEMBL356191 | 121038 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 496 | 7 | 2 | 4 | 5.3 | CCC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/0960-894X(95)00556-9 | |||
| 9806412 | 207351 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 511 | 5 | 3 | 6 | 2.9 | CN1C(=O)C(NC(=O)Nc2cccc(C(=O)NS(C)(=O)=O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1016/0960-894X(95)00399-E | |||
| CHEMBL75892 | 207351 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 511 | 5 | 3 | 6 | 2.9 | CN1C(=O)C(NC(=O)Nc2cccc(C(=O)NS(C)(=O)=O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1016/0960-894X(95)00399-E | |||
| 10814625 | 83500 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 481 | 5 | 3 | 7 | 2.9 | CN1C(=O)[C@H](NC(=O)Nc2cccc(N(C)c3nn[nH]n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm9506736 | |||
| CHEMBL22003 | 83500 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 481 | 5 | 3 | 7 | 2.9 | CN1C(=O)[C@H](NC(=O)Nc2cccc(N(C)c3nn[nH]n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm9506736 | |||
| 155540415 | 173042 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 1862 | 71 | 17 | 23 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4516868 | 173042 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 1862 | 71 | 17 | 23 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 18957759 | 103072 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 573 | 6 | 3 | 6 | 4.3 | CN1C(=O)C(NC(=O)Nc2cccc(C(=O)NS(=O)(=O)c3ccccc3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1016/0960-894X(95)00399-E | |||
| CHEMBL306944 | 103072 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 573 | 6 | 3 | 6 | 4.3 | CN1C(=O)C(NC(=O)Nc2cccc(C(=O)NS(=O)(=O)c3ccccc3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1016/0960-894X(95)00399-E | |||
| 15667014 | 107314 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 976 | 28 | 10 | 11 | 1.5 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
| CHEMBL316944 | 107314 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 976 | 28 | 10 | 11 | 1.5 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
| 10673307 | 110699 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 511 | 7 | 3 | 5 | 4.2 | CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(NC=O)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm960669+ | |||
| CHEMBL325746 | 110699 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 511 | 7 | 3 | 5 | 4.2 | CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(NC=O)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm960669+ | |||
| 44300745 | 200807 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 562 | 6 | 3 | 5 | 5.3 | COC(=O)c1cccc(NC(=O)N[C@@H]2C[C@H](C3CCCCC3)c3ccc(C)cc3N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00327-P | |||
| CHEMBL57643 | 200807 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 562 | 6 | 3 | 5 | 5.3 | COC(=O)c1cccc(NC(=O)N[C@@H]2C[C@H](C3CCCCC3)c3ccc(C)cc3N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00327-P | |||
| CHEMBL1806526 | 211431 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CO)NC(=O)[C@@H](CO)NC(=O)[C@@H](CO)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm101279a | |||||
| 162657745 | 181122 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 1475 | 37 | 14 | 19 | -1.1 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/acs.jmedchem.0c01233 | |||
| CHEMBL4759105 | 181122 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 1475 | 37 | 14 | 19 | -1.1 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/acs.jmedchem.0c01233 | |||
| 9984739 | 114878 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 538 | 5 | 3 | 3 | 6.2 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2C1CCCCC1 | 10.1021/jm00048a015 | |||
| CHEMBL334100 | 114878 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 538 | 5 | 3 | 3 | 6.2 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2C1CCCCC1 | 10.1021/jm00048a015 | |||
| 10369336 | 116819 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 517 | 7 | 2 | 4 | 4.5 | CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| CHEMBL337574 | 116819 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 517 | 7 | 2 | 4 | 4.5 | CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| 10480792 | 45814 | None | 0 | Mouse | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL153095 | 45814 | None | 0 | Mouse | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL3350686 | 45814 | None | 0 | Mouse | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| 10009526 | 110566 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 655 | 6 | 3 | 7 | 4.6 | O=C(Nc1cccc(-c2nn[nH]n2)c1)NC1N=C(c2ccccc2F)c2cccc(Cl)c2N(CC(=O)N2CC3CCC(CC3)C2)C1=O | 10.1016/s0960-894x(98)00237-6 | |||
| CHEMBL32492 | 110566 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 655 | 6 | 3 | 7 | 4.6 | O=C(Nc1cccc(-c2nn[nH]n2)c1)NC1N=C(c2ccccc2F)c2cccc(Cl)c2N(CC(=O)N2CC3CCC(CC3)C2)C1=O | 10.1016/s0960-894x(98)00237-6 | |||
| 145992870 | 166984 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 475 | 7 | 4 | 7 | 3.8 | CCOc1ccc(-n2c(NNC(=S)Nc3cccc(C(=O)O)c3)nc3ccccc3c2=O)cc1 | 10.1039/C7MD00171A | |||
| CHEMBL4286087 | 166984 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 475 | 7 | 4 | 7 | 3.8 | CCOc1ccc(-n2c(NNC(=S)Nc3cccc(C(=O)O)c3)nc3ccccc3c2=O)cc1 | 10.1039/C7MD00171A | |||
| 10484212 | 99933 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 635 | 6 | 3 | 7 | 4.3 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F | 10.1016/s0960-894x(98)00237-6 | |||
| CHEMBL285921 | 99933 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 635 | 6 | 3 | 7 | 4.3 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F | 10.1016/s0960-894x(98)00237-6 | |||
| 10484212 | 99933 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 635 | 6 | 3 | 7 | 4.3 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F | 10.1016/S0960-894X(96)00609-9 | |||
| CHEMBL285921 | 99933 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 635 | 6 | 3 | 7 | 4.3 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F | 10.1016/S0960-894X(96)00609-9 | |||
| 44301015 | 201517 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 609 | 7 | 5 | 7 | 3.7 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)Nc3nn[nH]n3)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
| CHEMBL58658 | 201517 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 609 | 7 | 5 | 7 | 3.7 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)Nc3nn[nH]n3)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
| CHEMBL1806772 | 211437 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm101279a | |||||
| 6439414 | 3025 | None | 13 | Mouse | Binding | pIC50 | = | 9.2 | 9.2 | 2454 | 2 | ChEMBL | 612 | 11 | 5 | 5 | 4.6 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O | 10.1021/jm00105a062 | |||
| 867 | 3025 | None | 13 | Mouse | Binding | pIC50 | = | 9.2 | 9.2 | 2454 | 2 | ChEMBL | 612 | 11 | 5 | 5 | 4.6 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O | 10.1021/jm00105a062 | |||
| CHEMBL3351022 | 3025 | None | 13 | Mouse | Binding | pIC50 | = | 9.2 | 9.2 | 2454 | 2 | ChEMBL | 612 | 11 | 5 | 5 | 4.6 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O | 10.1021/jm00105a062 | |||
| CHEMBL341460 | 3025 | None | 13 | Mouse | Binding | pIC50 | = | 9.2 | 9.2 | 2454 | 2 | ChEMBL | 612 | 11 | 5 | 5 | 4.6 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O | 10.1021/jm00105a062 | |||
| 44368728 | 119570 | None | 0 | Mouse | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 596 | 11 | 5 | 4 | 4.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL345512 | 119570 | None | 0 | Mouse | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 596 | 11 | 5 | 4 | 4.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL2370335 | 212289 | None | 0 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | None | None | None | CCC[C@@H]1CCN(C(=O)[C@@H]2Cc3c[nH]c4cccc(c34)CC(=O)N2)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(96)00546-X | |||||
| 18656023 | 104938 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 573 | 6 | 3 | 6 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NS(=O)(=O)c3ccccc3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1016/0960-894X(95)00399-E | |||
| CHEMBL311154 | 104938 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 573 | 6 | 3 | 6 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NS(=O)(=O)c3ccccc3)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1016/0960-894X(95)00399-E | |||
| 18656022 | 207256 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 539 | 6 | 3 | 6 | 3.6 | CC(C)S(=O)(=O)NC(=O)c1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/0960-894X(95)00399-E | |||
| CHEMBL75019 | 207256 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 539 | 6 | 3 | 6 | 3.6 | CC(C)S(=O)(=O)NC(=O)c1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/0960-894X(95)00399-E | |||
| CHEMBL407057 | 215095 | None | 1 | Human | Binding | pIC50 | = | 9.1 | 9.1 | 120 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O | 10.1021/jm960078j | |||||
| 44369595 | 168630 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 475 | 7 | 2 | 7 | 4.2 | Cc1cccc(NCNC2N=C(c3nccs3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
| CHEMBL435447 | 168630 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 475 | 7 | 2 | 7 | 4.2 | Cc1cccc(NCNC2N=C(c3nccs3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
| CHEMBL1806527 | 211432 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm101279a | |||||
| 9853654 | 22797 | None | 34 | Mouse | Binding | pIC50 | = | 9.1 | 9.1 | -31 | 2 | ChEMBL | 767 | 20 | 8 | 9 | 1.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00092a007 | |||
| CHEMBL1328 | 22797 | None | 34 | Mouse | Binding | pIC50 | = | 9.1 | 9.1 | -31 | 2 | ChEMBL | 767 | 20 | 8 | 9 | 1.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00092a007 | |||
| 14802543 | 170582 | None | 0 | Mouse | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 600 | 11 | 5 | 5 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CC(=O)O)c1ccccc1 | 10.1021/jm00105a062 | |||
| CHEMBL2112693 | 170582 | None | 0 | Mouse | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 600 | 11 | 5 | 5 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CC(=O)O)c1ccccc1 | 10.1021/jm00105a062 | |||
| CHEMBL444902 | 170582 | None | 0 | Mouse | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 600 | 11 | 5 | 5 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CC(=O)O)c1ccccc1 | 10.1021/jm00105a062 | |||
| 9853654 | 22797 | None | 34 | Mouse | Binding | pIC50 | = | 9.1 | 9.1 | -31 | 2 | ChEMBL | 767 | 20 | 8 | 9 | 1.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00105a062 | |||
| CHEMBL1328 | 22797 | None | 34 | Mouse | Binding | pIC50 | = | 9.1 | 9.1 | -31 | 2 | ChEMBL | 767 | 20 | 8 | 9 | 1.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00105a062 | |||
| 14802525 | 116791 | None | 1 | Mouse | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 626 | 12 | 5 | 5 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 | 10.1021/jm00105a062 | |||
| CHEMBL337384 | 116791 | None | 1 | Mouse | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 626 | 12 | 5 | 5 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 | 10.1021/jm00105a062 | |||
| 10392653 | 119105 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 544 | 5 | 2 | 5 | 3.4 | CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3ccc(Cl)cc3)N=C(c3ccccc3)c3ccccc32)CC1 | 10.1021/jm00078a018 | |||
| CHEMBL342640 | 119105 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 544 | 5 | 2 | 5 | 3.4 | CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3ccc(Cl)cc3)N=C(c3ccccc3)c3ccccc32)CC1 | 10.1021/jm00078a018 | |||
| 9853654 | 22797 | None | 34 | Mouse | Binding | pIC50 | = | 9.1 | 9.1 | -31 | 2 | ChEMBL | 767 | 20 | 8 | 9 | 1.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00057a005 | |||
| CHEMBL1328 | 22797 | None | 34 | Mouse | Binding | pIC50 | = | 9.1 | 9.1 | -31 | 2 | ChEMBL | 767 | 20 | 8 | 9 | 1.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00057a005 | |||
| 44368613 | 121066 | None | 0 | Mouse | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 610 | 12 | 5 | 4 | 4.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL356419 | 121066 | None | 0 | Mouse | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 610 | 12 | 5 | 4 | 4.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| 44300852 | 102026 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 566 | 6 | 4 | 6 | 4.1 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
| CHEMBL301418 | 102026 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 566 | 6 | 4 | 6 | 4.1 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
| 10009450 | 99920 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 649 | 7 | 3 | 7 | 4.5 | CCc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F | 10.1016/s0960-894x(98)00237-6 | |||
| CHEMBL285850 | 99920 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 649 | 7 | 3 | 7 | 4.5 | CCc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F | 10.1016/s0960-894x(98)00237-6 | |||
| 44293998 | 188531 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 609 | 6 | 2 | 5 | 5.3 | CC(=O)c1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 | 10.1016/S0960-894X(96)00609-9 | |||
| CHEMBL50215 | 188531 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 609 | 6 | 2 | 5 | 5.3 | CC(=O)c1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 | 10.1016/S0960-894X(96)00609-9 | |||
| 22883501 | 10424 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 552 | 6 | 2 | 6 | 5.0 | CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N3CCCCC3)c2)N=C(c2ccccn2)c2ccccc21 | 10.1021/jm960669+ | |||
| CHEMBL116300 | 10424 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 552 | 6 | 2 | 6 | 5.0 | CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N3CCCCC3)c2)N=C(c2ccccn2)c2ccccc21 | 10.1021/jm960669+ | |||
| 21842353 | 121096 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 550 | 7 | 2 | 4 | 6.5 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C3CCCCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
| CHEMBL356631 | 121096 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 550 | 7 | 2 | 4 | 6.5 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C3CCCCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
| 44300863 | 200805 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 619 | 7 | 4 | 6 | 3.7 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(C)(=O)=O)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
| CHEMBL57642 | 200805 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 619 | 7 | 4 | 6 | 3.7 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(C)(=O)=O)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
| 44300891 | 202010 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 586 | 7 | 4 | 6 | 5.1 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2CC1CCCCC1 | 10.1016/0960-894X(95)00327-P | |||
| CHEMBL59234 | 202010 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 586 | 7 | 4 | 6 | 5.1 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2CC1CCCCC1 | 10.1016/0960-894X(95)00327-P | |||
| 15281185 | 49468 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 484 | 5 | 2 | 6 | 3.7 | Cc1cccc(NC(=O)NC2N=C(c3cnccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
| CHEMBL156484 | 49468 | None | 0 | Rat | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 484 | 5 | 2 | 6 | 3.7 | Cc1cccc(NC(=O)NC2N=C(c3cnccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
| 155524181 | 170956 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 1820 | 71 | 18 | 22 | 2.7 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4453982 | 170956 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 1820 | 71 | 18 | 22 | 2.7 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL1807151 | 211438 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CO)NC(=O)[C@@H](CO)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm101279a | |||||
| 162673067 | 183249 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 1403 | 38 | 16 | 20 | -3.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.0c01233 | |||
| CHEMBL4795198 | 183249 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 1403 | 38 | 16 | 20 | -3.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.0c01233 | |||
| CHEMBL2310858 | 211949 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | None | None | None | CCCC1CCN([C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc2ccccc2)C(N)=O)[C@H]1C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)CCc1ccc(OS(=O)(=O)O)cc1 | 10.1021/jm00094a001 | |||||
| 44348901 | 141915 | None | 0 | Bovine | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 1000 | 24 | 11 | 11 | 2.3 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cccc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)c1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
| CHEMBL386376 | 141915 | None | 0 | Bovine | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 1000 | 24 | 11 | 11 | 2.3 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cccc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)c1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
| 4627 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm8007618 | |||||
| 864 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm8007618 | |||||
| 9833444 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm8007618 | |||||
| CHEMBL1121 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm8007618 | |||||
| DB09142 | 822 | None | 42 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm8007618 | |||||
| 10031259 | 4300 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 586 | 12 | 3 | 4 | 4.3 | O=C(Cc1c[nH]c2ccccc12)N[C@@H](Cc1ccccc1)C(=O)N(CCC1CCCCC1)CC(=O)N1CCC[C@H]1C(=O)O | 10.1016/S0960-894X(96)00546-X | |||
| CHEMBL100799 | 4300 | None | 0 | Rat | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 586 | 12 | 3 | 4 | 4.3 | O=C(Cc1c[nH]c2ccccc12)N[C@@H](Cc1ccccc1)C(=O)N(CCC1CCCCC1)CC(=O)N1CCC[C@H]1C(=O)O | 10.1016/S0960-894X(96)00546-X | |||
| 44396655 | 122116 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 608 | 8 | 2 | 5 | 5.7 | C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 | 10.1021/jm0498755 | |||
| CHEMBL359589 | 122116 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 608 | 8 | 2 | 5 | 5.7 | C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 | 10.1021/jm0498755 | |||
| 44293971 | 189141 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 611 | 6 | 3 | 5 | 4.8 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(C(=O)O)c1)N=C2c1ccccc1F | 10.1016/S0960-894X(96)00609-9 | |||
| CHEMBL50926 | 189141 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 611 | 6 | 3 | 5 | 4.8 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(C(=O)O)c1)N=C2c1ccccc1F | 10.1016/S0960-894X(96)00609-9 | |||
| 44300889 | 100815 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 532 | 6 | 4 | 6 | 3.8 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2C(C)C | 10.1016/0960-894X(95)00327-P | |||
| CHEMBL292856 | 100815 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 532 | 6 | 4 | 6 | 3.8 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2C(C)C | 10.1016/0960-894X(95)00327-P | |||
| 10744557 | 32734 | None | 0 | Mouse | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 521 | 7 | 4 | 4 | 4.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1C(=O)O | 10.1021/jm970065l | |||
| CHEMBL141370 | 32734 | None | 0 | Mouse | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 521 | 7 | 4 | 4 | 4.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1C(=O)O | 10.1021/jm970065l | |||
| 10435698 | 141495 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 490 | 6 | 2 | 5 | 4.2 | CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80683-6 | |||
| CHEMBL38404 | 141495 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 490 | 6 | 2 | 5 | 4.2 | CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80683-6 | |||
| 44301037 | 100911 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 633 | 8 | 4 | 6 | 4.0 | CCS(=O)(=O)NC(=O)c1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccc(C)cc3N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00327-P | |||
| CHEMBL293490 | 100911 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 633 | 8 | 4 | 6 | 4.0 | CCS(=O)(=O)NC(=O)c1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccc(C)cc3N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00327-P | |||
| 10814373 | 209561 | None | 0 | Mouse | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 474 | 7 | 3 | 8 | 4.2 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc([N+](=O)[O-])c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
| CHEMBL9203 | 209561 | None | 0 | Mouse | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 474 | 7 | 3 | 8 | 4.2 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc([N+](=O)[O-])c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
| 10435698 | 141495 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 490 | 6 | 2 | 5 | 4.2 | CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00121a004 | |||
| CHEMBL38404 | 141495 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 490 | 6 | 2 | 5 | 4.2 | CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00121a004 | |||
| 9853654 | 22797 | None | 34 | Human | Binding | pIC50 | = | 9 | 9.0 | 31 | 2 | ChEMBL | 767 | 20 | 8 | 9 | 1.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.0c01233 | |||
| CHEMBL1328 | 22797 | None | 34 | Human | Binding | pIC50 | = | 9 | 9.0 | 31 | 2 | ChEMBL | 767 | 20 | 8 | 9 | 1.5 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.0c01233 | |||
| 10369805 | 100606 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 532 | 5 | 3 | 3 | 5.6 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 | 10.1021/jm00048a015 | |||
| CHEMBL291458 | 100606 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 532 | 5 | 3 | 3 | 5.6 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 | 10.1021/jm00048a015 | |||
| 44293999 | 188532 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 597 | 6 | 2 | 5 | 5.1 | COc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 | 10.1016/S0960-894X(96)00609-9 | |||
| CHEMBL50216 | 188532 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 597 | 6 | 2 | 5 | 5.1 | COc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 | 10.1016/S0960-894X(96)00609-9 | |||
| 10074702 | 27622 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 500 | 8 | 2 | 6 | 4.0 | CCOC(=O)CCN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| CHEMBL136966 | 27622 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 500 | 8 | 2 | 6 | 4.0 | CCOC(=O)CCN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| 10435698 | 141495 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 490 | 6 | 2 | 5 | 4.2 | CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| CHEMBL38404 | 141495 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 490 | 6 | 2 | 5 | 4.2 | CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| 4627 | 822 | None | 42 | Rat | Binding | pIC50 | = | 9 | 9.0 | 1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm00079a003 | |||||
| 864 | 822 | None | 42 | Rat | Binding | pIC50 | = | 9 | 9.0 | 1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm00079a003 | |||||
| 9833444 | 822 | None | 42 | Rat | Binding | pIC50 | = | 9 | 9.0 | 1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm00079a003 | |||||
| CHEMBL1121 | 822 | None | 42 | Rat | Binding | pIC50 | = | 9 | 9.0 | 1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm00079a003 | |||||
| DB09142 | 822 | None | 42 | Rat | Binding | pIC50 | = | 9 | 9.0 | 1 | 5 | ChEMBL | None | None | None | None | 10.1021/jm00079a003 | |||||
| 44376112 | 120257 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 452 | 4 | 3 | 6 | 2.8 | CN1C(=O)[C@@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00032a003 | |||
| CHEMBL351854 | 120257 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 452 | 4 | 3 | 6 | 2.8 | CN1C(=O)[C@@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00032a003 | |||
| 10007047 | 16930 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 524 | 5 | 3 | 3 | 5.8 | CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](C2CCCCC2)c2ccccc21 | 10.1021/jm00048a015 | |||
| CHEMBL125253 | 16930 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 524 | 5 | 3 | 3 | 5.8 | CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](C2CCCCC2)c2ccccc21 | 10.1021/jm00048a015 | |||
| CHEMBL218327 | 211853 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -2 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
| 5311201 | 209854 | None | 26 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -27 | 9 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00121a004 | |||
| CHEMBL9387 | 209854 | None | 26 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -27 | 9 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00121a004 | |||
| 15667019 | 210688 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 905 | 26 | 9 | 10 | 2.0 | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCNC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
| CHEMBL98631 | 210688 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 905 | 26 | 9 | 10 | 2.0 | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCNC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
| 10576729 | 59248 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 481 | 5 | 4 | 7 | 3.2 | Cc1ccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1Nc1nn[nH]n1 | 10.1021/jm9506736 | |||
| CHEMBL170275 | 59248 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 481 | 5 | 4 | 7 | 3.2 | Cc1ccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1Nc1nn[nH]n1 | 10.1021/jm9506736 | |||
| 5311201 | 209854 | None | 26 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -27 | 9 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00164a020 | |||
| CHEMBL9387 | 209854 | None | 26 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -27 | 9 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00164a020 | |||
| 10789887 | 209886 | None | 0 | Mouse | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 454 | 6 | 3 | 7 | 4.2 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C#N)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
| CHEMBL9405 | 209886 | None | 0 | Mouse | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 454 | 6 | 3 | 7 | 4.2 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C#N)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
| 10075014 | 163076 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 508 | 6 | 2 | 5 | 4.4 | CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00121a004 | |||
| CHEMBL417521 | 163076 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 508 | 6 | 2 | 5 | 4.4 | CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00121a004 | |||
| 10075014 | 163076 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 508 | 6 | 2 | 5 | 4.4 | CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00078a018 | |||
| CHEMBL417521 | 163076 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 508 | 6 | 2 | 5 | 4.4 | CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00078a018 | |||
| 44368562 | 122029 | None | 0 | Mouse | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 588 | 12 | 5 | 5 | 4.3 | C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL359076 | 122029 | None | 0 | Mouse | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 588 | 12 | 5 | 5 | 4.3 | C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| 10696336 | 207793 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 487 | 5 | 3 | 4 | 4.6 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)CCC3)N=C([C@H]2CC(C)(C)CCN2)c2ccccc21 | 10.1021/jm9608523 | |||
| CHEMBL79565 | 207793 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 487 | 5 | 3 | 4 | 4.6 | CCCN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)CCC3)N=C([C@H]2CC(C)(C)CCN2)c2ccccc21 | 10.1021/jm9608523 | |||
| 10364786 | 104927 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 419 | 2 | 2 | 4 | 3.7 | Cc1cccc(NC(=O)NC2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
| CHEMBL311061 | 104927 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 419 | 2 | 2 | 4 | 3.7 | Cc1cccc(NC(=O)NC2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
| 10768084 | 10021 | None | 1 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 512 | 6 | 2 | 6 | 4.1 | CN(C)c1cccc(NC(=O)N[C@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
| CHEMBL114991 | 10021 | None | 1 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 512 | 6 | 2 | 6 | 4.1 | CN(C)c1cccc(NC(=O)N[C@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1021/jm960669+ | |||
| 10815039 | 112910 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 493 | 5 | 2 | 5 | 4.5 | CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C#N)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm960669+ | |||
| CHEMBL330917 | 112910 | None | 0 | Rat | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 493 | 5 | 2 | 5 | 4.5 | CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C#N)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm960669+ | |||
| 162658676 | 181088 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 1489 | 37 | 14 | 19 | -0.7 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/acs.jmedchem.0c01233 | |||
| CHEMBL4758706 | 181088 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 1489 | 37 | 14 | 19 | -0.7 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/acs.jmedchem.0c01233 | |||
| 71450869 | 84418 | None | 0 | Mouse | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 650 | 12 | 5 | 6 | 4.3 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCS(=O)(=O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
| CHEMBL2112338 | 84418 | None | 0 | Mouse | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 650 | 12 | 5 | 6 | 4.3 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCS(=O)(=O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
| CHEMBL2219559 | 84418 | None | 0 | Mouse | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 650 | 12 | 5 | 6 | 4.3 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCS(=O)(=O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
| 4627 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 8.9 | 8.9 | - | 5 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(01)00044-0 | |||||
| 864 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 8.9 | 8.9 | - | 5 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(01)00044-0 | |||||
| 9833444 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 8.9 | 8.9 | - | 5 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(01)00044-0 | |||||
| CHEMBL1121 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 8.9 | 8.9 | - | 5 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(01)00044-0 | |||||
| DB09142 | 822 | None | 42 | Mouse | Binding | pIC50 | = | 8.9 | 8.9 | - | 5 | ChEMBL | None | None | None | None | 10.1016/s0960-894x(01)00044-0 | |||||
| 10364786 | 104927 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 419 | 2 | 2 | 4 | 3.7 | Cc1cccc(NC(=O)NC2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm9608523 | |||
| CHEMBL311061 | 104927 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 419 | 2 | 2 | 4 | 3.7 | Cc1cccc(NC(=O)NC2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm9608523 | |||
| 10251516 | 13378 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 419 | 2 | 2 | 4 | 3.7 | Cc1cccc(NC(=O)N[C@@H]2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
| CHEMBL1192472 | 13378 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 419 | 2 | 2 | 4 | 3.7 | Cc1cccc(NC(=O)N[C@@H]2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
| CHEMBL543712 | 13378 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 419 | 2 | 2 | 4 | 3.7 | Cc1cccc(NC(=O)N[C@@H]2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
| 44301034 | 101642 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 556 | 6 | 3 | 5 | 4.8 | COC(=O)c1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccc(C)cc3N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00327-P | |||
| CHEMBL298627 | 101642 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 556 | 6 | 3 | 5 | 4.8 | COC(=O)c1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccc(C)cc3N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00327-P | |||
| 44210535 | 103054 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 434 | 4 | 3 | 4 | 3.9 | CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1016/0960-894X(95)00399-E | |||
| CHEMBL306803 | 103054 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 434 | 4 | 3 | 4 | 3.9 | CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 | 10.1016/0960-894X(95)00399-E | |||
| 162673242 | 183314 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 1475 | 37 | 14 | 19 | -1.1 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/acs.jmedchem.0c01233 | |||
| CHEMBL4795913 | 183314 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 1475 | 37 | 14 | 19 | -1.1 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/acs.jmedchem.0c01233 | |||
| 15667012 | 169153 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 976 | 28 | 10 | 11 | 1.5 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
| CHEMBL439591 | 169153 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 976 | 28 | 10 | 11 | 1.5 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
| 10482588 | 18549 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 546 | 6 | 3 | 3 | 5.8 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2Cc1ccccc1 | 10.1021/jm00048a015 | |||
| CHEMBL127521 | 18549 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 546 | 6 | 3 | 3 | 5.8 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2Cc1ccccc1 | 10.1021/jm00048a015 | |||
| 10436569 | 77874 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 515 | 5 | 2 | 4 | 4.3 | O=C(Nc1ccc(Cl)cc1)N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1021/jm00078a018 | |||
| CHEMBL2092976 | 77874 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 515 | 5 | 2 | 4 | 4.3 | O=C(Nc1ccc(Cl)cc1)N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1021/jm00078a018 | |||
| 10791546 | 209541 | None | 0 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 501 | 8 | 3 | 8 | 4.5 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 | 10.1021/jm970373j | |||
| CHEMBL9188 | 209541 | None | 0 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 501 | 8 | 3 | 8 | 4.5 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 | 10.1021/jm970373j | |||
| 10346998 | 18117 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 532 | 5 | 2 | 3 | 5.7 | CN(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21)C(C)(C)C | 10.1021/jm00048a015 | |||
| CHEMBL126865 | 18117 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 532 | 5 | 2 | 3 | 5.7 | CN(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21)C(C)(C)C | 10.1021/jm00048a015 | |||
| 10837729 | 106501 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 461 | 5 | 3 | 4 | 4.5 | CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CC(C)(C)CCN2)c2ccccc21 | 10.1021/jm9608523 | |||
| CHEMBL313983 | 106501 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 461 | 5 | 3 | 4 | 4.5 | CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CC(C)(C)CCN2)c2ccccc21 | 10.1021/jm9608523 | |||
| CHEMBL206974 | 211641 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | 1 | 5 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
| 21842365 | 119818 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 495 | 6 | 2 | 5 | 4.5 | Cc1cccc(NC(=O)NC2N=C(c3cccnc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
| CHEMBL347843 | 119818 | None | 0 | Rat | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 495 | 6 | 2 | 5 | 4.5 | Cc1cccc(NC(=O)NC2N=C(c3cccnc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
| 4627 | 822 | None | 42 | Human | Binding | pIC50 | = | 8.8 | 8.8 | -1 | 5 | ChEMBL | None | None | None | None | 10.1016/S0960-894X(00)80680-0 | |||||
| 864 | 822 | None | 42 | Human | Binding | pIC50 | = | 8.8 | 8.8 | -1 | 5 | ChEMBL | None | None | None | None | 10.1016/S0960-894X(00)80680-0 | |||||
| 9833444 | 822 | None | 42 | Human | Binding | pIC50 | = | 8.8 | 8.8 | -1 | 5 | ChEMBL | None | None | None | None | 10.1016/S0960-894X(00)80680-0 | |||||
| CHEMBL1121 | 822 | None | 42 | Human | Binding | pIC50 | = | 8.8 | 8.8 | -1 | 5 | ChEMBL | None | None | None | None | 10.1016/S0960-894X(00)80680-0 | |||||
| DB09142 | 822 | None | 42 | Human | Binding | pIC50 | = | 8.8 | 8.8 | -1 | 5 | ChEMBL | None | None | None | None | 10.1016/S0960-894X(00)80680-0 | |||||
| CHEMBL1806530 | 211434 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm101279a | |||||
| 10414170 | 170721 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 515 | 5 | 2 | 4 | 4.3 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1021/jm00078a018 | |||
| CHEMBL445095 | 170721 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 515 | 5 | 2 | 4 | 4.3 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1021/jm00078a018 | |||
| CHEMBL382349 | 214762 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | 1 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
| 52949124 | 876 | None | 4 | Human | Binding | pIC50 | = | 8.8 | 8.8 | 2 | 2 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| 9055 | 876 | None | 4 | Human | Binding | pIC50 | = | 8.8 | 8.8 | 2 | 2 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| CHEMBL1269258 | 876 | None | 4 | Human | Binding | pIC50 | = | 8.8 | 8.8 | 2 | 2 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| DB12694 | 876 | None | 4 | Human | Binding | pIC50 | = | 8.8 | 8.8 | 2 | 2 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| 44300890 | 101945 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 580 | 7 | 4 | 6 | 4.3 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2Cc1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
| CHEMBL300776 | 101945 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 580 | 7 | 4 | 6 | 4.3 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2Cc1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
| 108187 | 926 | None | 30 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | -9 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1016/S0960-894X(00)80273-5 | |||
| 873 | 926 | None | 30 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | -9 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1016/S0960-894X(00)80273-5 | |||
| CHEMBL2062154 | 926 | None | 30 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | -9 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1016/S0960-894X(00)80273-5 | |||
| CHEMBL287735 | 926 | None | 30 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | -9 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1016/S0960-894X(00)80273-5 | |||
| 155534566 | 172078 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 1409 | 38 | 15 | 21 | -2.2 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Cn1cc([C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.9b01936 | |||
| CHEMBL4470833 | 172078 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 1409 | 38 | 15 | 21 | -2.2 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Cn1cc([C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.9b01936 | |||
| 59923871 | 73986 | None | 1 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCC(NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(00)80156-0 | |||
| CHEMBL2021374 | 73986 | None | 1 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCC(NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(00)80156-0 | |||
| 71452691 | 78660 | None | 0 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 671 | 12 | 5 | 7 | 3.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)C[S+]([O-])c1nc[nH]n1)c1ccccc1 | 10.1021/jm00092a007 | |||
| CHEMBL2112336 | 78660 | None | 0 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 671 | 12 | 5 | 7 | 3.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)C[S+]([O-])c1nc[nH]n1)c1ccccc1 | 10.1021/jm00092a007 | |||
| 14802538 | 96742 | None | 0 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
| CHEMBL263969 | 96742 | None | 0 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
| 108187 | 926 | None | 30 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | -9 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm00105a062 | |||
| 873 | 926 | None | 30 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | -9 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm00105a062 | |||
| CHEMBL2062154 | 926 | None | 30 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | -9 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm00105a062 | |||
| CHEMBL287735 | 926 | None | 30 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | -9 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm00105a062 | |||
| 14802537 | 86022 | None | 0 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(01)80769-1 | |||
| CHEMBL2304062 | 86022 | None | 0 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(01)80769-1 | |||
| 108187 | 926 | None | 30 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | -9 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1016/S0960-894X(00)80685-X | |||
| 873 | 926 | None | 30 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | -9 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1016/S0960-894X(00)80685-X | |||
| CHEMBL2062154 | 926 | None | 30 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | -9 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1016/S0960-894X(00)80685-X | |||
| CHEMBL287735 | 926 | None | 30 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | -9 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1016/S0960-894X(00)80685-X | |||
| 14802538 | 96742 | None | 0 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/s0960-894x(98)00677-5 | |||
| CHEMBL263969 | 96742 | None | 0 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/s0960-894x(98)00677-5 | |||
| 108187 | 926 | None | 30 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | -9 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1016/S0960-894X(97)00356-9 | |||
| 873 | 926 | None | 30 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | -9 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1016/S0960-894X(97)00356-9 | |||
| CHEMBL2062154 | 926 | None | 30 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | -9 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1016/S0960-894X(97)00356-9 | |||
| CHEMBL287735 | 926 | None | 30 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | -9 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1016/S0960-894X(97)00356-9 | |||
| 44368727 | 119569 | None | 0 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 598 | 12 | 5 | 4 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL345511 | 119569 | None | 0 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 598 | 12 | 5 | 4 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1021/jm00057a005 | |||
| 108187 | 926 | None | 30 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | -9 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm970065l | |||
| 873 | 926 | None | 30 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | -9 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm970065l | |||
| CHEMBL2062154 | 926 | None | 30 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | -9 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm970065l | |||
| CHEMBL287735 | 926 | None | 30 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | -9 | 5 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O | 10.1021/jm970065l | |||
| 14802539 | 76580 | None | 1 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(00)80652-6 | |||
| CHEMBL2062144 | 76580 | None | 1 | Mouse | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(00)80652-6 | |||
| CHEMBL35471 | 214192 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | None | None | None | CCS[C@@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00001a019 | |||||
| 44293812 | 101770 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 645 | 5 | 2 | 4 | 5.9 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(Br)c1)N=C2c1ccccc1F | 10.1016/S0960-894X(96)00609-9 | |||
| CHEMBL299523 | 101770 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 645 | 5 | 2 | 4 | 5.9 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(Br)c1)N=C2c1ccccc1F | 10.1016/S0960-894X(96)00609-9 | |||
| 44348651 | 168340 | None | 0 | Bovine | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 952 | 26 | 11 | 11 | 0.6 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
| CHEMBL433647 | 168340 | None | 0 | Bovine | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 952 | 26 | 11 | 11 | 0.6 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
| 9866980 | 4658 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 423 | 3 | 2 | 4 | 4.6 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N3C[C@H](C)N=C23)c1 | 10.1016/0960-894X(95)00530-0 | |||
| CHEMBL103119 | 4658 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 423 | 3 | 2 | 4 | 4.6 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N3C[C@H](C)N=C23)c1 | 10.1016/0960-894X(95)00530-0 | |||
| 155553502 | 174279 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 1822 | 72 | 19 | 22 | 3.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4547294 | 174279 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 1822 | 72 | 19 | 22 | 3.0 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 21842326 | 121355 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 496 | 8 | 2 | 4 | 5.3 | CCC(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/0960-894X(95)00556-9 | |||
| CHEMBL358000 | 121355 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 496 | 8 | 2 | 4 | 5.3 | CCC(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/0960-894X(95)00556-9 | |||
| 9936789 | 209047 | None | 0 | Mouse | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 529 | 7 | 3 | 8 | 5.3 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C(=O)OC(C)(C)C)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
| CHEMBL8890 | 209047 | None | 0 | Mouse | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 529 | 7 | 3 | 8 | 5.3 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C(=O)OC(C)(C)C)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
| 44303664 | 100763 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 661 | 16 | 7 | 7 | 0.3 | CCCC1C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)N(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CN)C1 | 10.1016/S0960-894X(01)81005-2 | |||
| CHEMBL292493 | 100763 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 661 | 16 | 7 | 7 | 0.3 | CCCC1C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)N(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CN)C1 | 10.1016/S0960-894X(01)81005-2 | |||
| CHEMBL3143186 | 213598 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | None | None | None | CCC[C@@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00105a068 | |||||
| 52949124 | 876 | None | 4 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 2 | 2 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| 9055 | 876 | None | 4 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 2 | 2 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| CHEMBL1269258 | 876 | None | 4 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 2 | 2 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| DB12694 | 876 | None | 4 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 2 | 2 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| 10623795 | 209742 | None | 0 | Mouse | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 459 | 7 | 3 | 7 | 4.3 | COc1ccccc1NC(=O)NNc1nc2ccccc2c(=O)n1-c1cccc(OC(C)C)c1 | 10.1021/jm970373j | |||
| CHEMBL9319 | 209742 | None | 0 | Mouse | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 459 | 7 | 3 | 7 | 4.3 | COc1ccccc1NC(=O)NNc1nc2ccccc2c(=O)n1-c1cccc(OC(C)C)c1 | 10.1021/jm970373j | |||
| 9960432 | 39435 | None | 7 | Human | Binding | pIC50 | = | 8 | 8.0 | 12 | 2 | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm9601664 | |||
| CHEMBL147186 | 39435 | None | 7 | Human | Binding | pIC50 | = | 8 | 8.0 | 12 | 2 | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm9601664 | |||
| 46235271 | 73674 | None | 2 | Human | Binding | pIC50 | = | 8 | 8.0 | -2 | 2 | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
| CHEMBL2017835 | 73674 | None | 2 | Human | Binding | pIC50 | = | 8 | 8.0 | -2 | 2 | ChEMBL | 649 | 7 | 1 | 6 | 6.7 | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 | 10.1021/acs.jmedchem.5b01110 | |||
| 15667011 | 96710 | None | 1 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 990 | 29 | 9 | 11 | 2.0 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
| CHEMBL263742 | 96710 | None | 1 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 990 | 29 | 9 | 11 | 2.0 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
| 10102593 | 141592 | None | 2 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 1048 | 29 | 10 | 12 | 3.3 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(00)80679-4 | |||
| CHEMBL384505 | 141592 | None | 2 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 1048 | 29 | 10 | 12 | 3.3 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(00)80679-4 | |||
| 44333048 | 169360 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 1032 | 28 | 10 | 11 | 3.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 | 10.1021/jm00072a024 | |||
| CHEMBL441165 | 169360 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 1032 | 28 | 10 | 11 | 3.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 | 10.1021/jm00072a024 | |||
| 44329342 | 108485 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 571 | 7 | 3 | 5 | 5.5 | Cc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc([N+](=O)[O-])c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 | 10.1016/S0960-894X(01)80832-5 | |||
| CHEMBL319882 | 108485 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 571 | 7 | 3 | 5 | 5.5 | Cc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc([N+](=O)[O-])c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 | 10.1016/S0960-894X(01)80832-5 | |||
| 10255357 | 18525 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 498 | 5 | 3 | 3 | 5.0 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1021/jm00048a015 | |||
| CHEMBL127397 | 18525 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 498 | 5 | 3 | 3 | 5.0 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1021/jm00048a015 | |||
| 10393441 | 171816 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 580 | 7 | 3 | 3 | 6.5 | CC(C)(NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm00048a015 | |||
| CHEMBL446682 | 171816 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 580 | 7 | 3 | 3 | 6.5 | CC(C)(NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm00048a015 | |||
| 10102593 | 141592 | None | 2 | Rat | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 1048 | 29 | 10 | 12 | 3.3 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(00)80679-4 | |||
| CHEMBL384505 | 141592 | None | 2 | Rat | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 1048 | 29 | 10 | 12 | 3.3 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(00)80679-4 | |||
| 14843042 | 127642 | None | 0 | Mouse | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 485 | 5 | 1 | 3 | 6.5 | CCc1cccc(-n2c(CC(C)c3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 | 10.1021/jm00108a040 | |||
| CHEMBL36634 | 127642 | None | 0 | Mouse | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 485 | 5 | 1 | 3 | 6.5 | CCc1cccc(-n2c(CC(C)c3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 | 10.1021/jm00108a040 | |||
| 9983680 | 163418 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 506 | 7 | 2 | 5 | 3.8 | Cc1cccc(NC(=O)N[C@H](COC(=O)N2CCCC2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
| CHEMBL418987 | 163418 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 506 | 7 | 2 | 5 | 3.8 | Cc1cccc(NC(=O)N[C@H](COC(=O)N2CCCC2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
| 5311148 | 1896 | None | 8 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 587 | 8 | 1 | 5 | 5.9 | COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C | 10.1021/jm960249k | |||
| 865 | 1896 | None | 8 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 587 | 8 | 1 | 5 | 5.9 | COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C | 10.1021/jm960249k | |||
| CHEMBL293226 | 1896 | None | 8 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 587 | 8 | 1 | 5 | 5.9 | COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C | 10.1021/jm960249k | |||
| CHEMBL3142686 | 213588 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||||
| 44306823 | 205525 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 802 | 20 | 9 | 7 | 2.8 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(CCCCNC(=O)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | |||
| CHEMBL63707 | 205525 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 802 | 20 | 9 | 7 | 2.8 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(CCCCNC(=O)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | |||
| 15689733 | 106670 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 870 | 21 | 9 | 10 | 3.0 | COC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 | 10.1021/jm960509y | |||
| CHEMBL3142905 | 106670 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 870 | 21 | 9 | 10 | 3.0 | COC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 | 10.1021/jm960509y | |||
| 155515427 | 170052 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 1886 | 72 | 17 | 23 | 4.2 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4441596 | 170052 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 1886 | 72 | 17 | 23 | 4.2 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL1172246 | 211040 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | -1 | 4 | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc2ccccc2)C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC1=O | 10.1016/j.bmcl.2010.05.078 | |||||
| 21121108 | 82030 | None | 3 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 1048 | 29 | 10 | 12 | 3.3 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(00)80679-4 | |||
| CHEMBL216527 | 82030 | None | 3 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 1048 | 29 | 10 | 12 | 3.3 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(00)80679-4 | |||
| 5311148 | 1896 | None | 8 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 587 | 8 | 1 | 5 | 5.9 | COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C | 10.1021/jm970265x | |||
| 865 | 1896 | None | 8 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 587 | 8 | 1 | 5 | 5.9 | COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C | 10.1021/jm970265x | |||
| CHEMBL293226 | 1896 | None | 8 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 587 | 8 | 1 | 5 | 5.9 | COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C | 10.1021/jm970265x | |||
| 14444015 | 106733 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 635 | 15 | 6 | 6 | 3.8 | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NCc1ccccc1 | 10.1021/jm00123a003 | |||
| CHEMBL3143388 | 106733 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 635 | 15 | 6 | 6 | 3.8 | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NCc1ccccc1 | 10.1021/jm00123a003 | |||
| 44303224 | 142022 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 933 | 23 | 8 | 11 | 2.8 | CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
| CHEMBL387073 | 142022 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 933 | 23 | 8 | 11 | 2.8 | CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
| 44349393 | 16841 | None | 0 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 422 | 7 | 3 | 3 | 4.3 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCCCCCCCC1 | 10.1021/jm00079a003 | |||
| CHEMBL124764 | 16841 | None | 0 | Rat | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 422 | 7 | 3 | 3 | 4.3 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCCCCCCCC1 | 10.1021/jm00079a003 | |||
| CHEMBL285051 | 213321 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | None | None | None | CS[C@@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00001a019 | |||||
| CHEMBL37786 | 214718 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | None | None | None | CS[C@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00001a019 | |||||
| 44382805 | 59230 | None | 0 | Mouse | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 536 | 9 | 3 | 5 | 3.4 | CC(C)C[C@H](NC(=O)C(NC(=O)OC(C)(C)C)c1ccccc1)C(=O)N1CC(=O)N[C@@H](Cc2ccccc2)C1 | 10.1016/S0960-894X(01)80253-5 | |||
| CHEMBL170197 | 59230 | None | 0 | Mouse | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 536 | 9 | 3 | 5 | 3.4 | CC(C)C[C@H](NC(=O)C(NC(=O)OC(C)(C)C)c1ccccc1)C(=O)N1CC(=O)N[C@@H](Cc2ccccc2)C1 | 10.1016/S0960-894X(01)80253-5 | |||
| 44306888 | 102385 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 816 | 18 | 9 | 7 | 3.4 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1cccc(NC(=O)Nc2ccccc2C)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | |||
| CHEMBL303635 | 102385 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 816 | 18 | 9 | 7 | 3.4 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1cccc(NC(=O)Nc2ccccc2C)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | |||
| 44408590 | 161820 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 2 | ChEMBL | 1134 | 30 | 12 | 15 | 2.6 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O | 10.1021/jm050851n | |||
| CHEMBL413644 | 161820 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 2 | ChEMBL | 1134 | 30 | 12 | 15 | 2.6 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O | 10.1021/jm050851n | |||
| 44418923 | 161879 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 2 | ChEMBL | 1132 | 28 | 13 | 13 | 1.7 | CCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2[nH]1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
| CHEMBL414087 | 161879 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 2 | ChEMBL | 1132 | 28 | 13 | 13 | 1.7 | CCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2[nH]1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
| 44375063 | 55137 | None | 0 | Mouse | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 554 | 10 | 6 | 7 | 4.0 | O=C(O)c1ccc(NS(=O)(=O)c2ccc(N/N=C(/S)NCCc3c[nH]c4ccccc34)c([N+](=O)[O-])c2)cc1 | 10.1016/s0960-894x(01)00044-0 | |||
| CHEMBL161703 | 55137 | None | 0 | Mouse | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 554 | 10 | 6 | 7 | 4.0 | O=C(O)c1ccc(NS(=O)(=O)c2ccc(N/N=C(/S)NCCc3c[nH]c4ccccc34)c([N+](=O)[O-])c2)cc1 | 10.1016/s0960-894x(01)00044-0 | |||
| 14444011 | 106734 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 692 | 17 | 7 | 7 | 2.7 | CC(C)C[C@@H](CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm00123a003 | |||
| CHEMBL3143393 | 106734 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 692 | 17 | 7 | 7 | 2.7 | CC(C)C[C@@H](CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm00123a003 | |||
| 44366341 | 119384 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 649 | 16 | 6 | 6 | 3.8 | CC(C)C[C@@H](CC(=O)NC(CC(=O)O)C(=O)NCCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm00123a003 | |||
| CHEMBL344125 | 119384 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 649 | 16 | 6 | 6 | 3.8 | CC(C)C[C@@H](CC(=O)NC(CC(=O)O)C(=O)NCCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm00123a003 | |||
| 15104627 | 110541 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 462 | 7 | 2 | 3 | 4.7 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
| CHEMBL324760 | 110541 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 462 | 7 | 2 | 3 | 4.7 | CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
| 44341327 | 163427 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 504 | 13 | 3 | 2 | 6.3 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc2cc(F)ccc2[nH]1 | 10.1021/jm00116a002 | |||
| CHEMBL419031 | 163427 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 504 | 13 | 3 | 2 | 6.3 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc2cc(F)ccc2[nH]1 | 10.1021/jm00116a002 | |||
| 14991537 | 106852 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 921 | 24 | 9 | 11 | 2.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1cccc(OS(=O)(=O)O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
| CHEMBL3144535 | 106852 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 921 | 24 | 9 | 11 | 2.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1cccc(OS(=O)(=O)O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
| 14991543 | 106862 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 839 | 22 | 8 | 8 | 3.5 | Cc1ccc(CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm00089a010 | |||
| CHEMBL3144544 | 106862 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 839 | 22 | 8 | 8 | 3.5 | Cc1ccc(CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm00089a010 | |||
| 14991566 | 168336 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 831 | 22 | 8 | 8 | 3.9 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCC1CCCCC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
| CHEMBL433636 | 168336 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 831 | 22 | 8 | 8 | 3.9 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCC1CCCCC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
| 10391834 | 38235 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 516 | 11 | 3 | 4 | 4.5 | CC(C)N(C(=O)CN(C(=O)[C@@H](CCC(=O)O)NC(=O)Nc1ccccc1)c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(97)00062-0 | |||
| CHEMBL146206 | 38235 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 516 | 11 | 3 | 4 | 4.5 | CC(C)N(C(=O)CN(C(=O)[C@@H](CCC(=O)O)NC(=O)Nc1ccccc1)c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(97)00062-0 | |||
| 10556460 | 209197 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 677 | 10 | 0 | 6 | 7.4 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(Cc4ccccc4)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm960249k | |||
| CHEMBL89953 | 209197 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 677 | 10 | 0 | 6 | 7.4 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(Cc4ccccc4)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm960249k | |||
| 44306360 | 157967 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 1 | ChEMBL | 816 | 18 | 9 | 7 | 3.4 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1ccc(NC(=O)Nc2ccccc2C)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | |||
| CHEMBL408395 | 157967 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 1 | ChEMBL | 816 | 18 | 9 | 7 | 3.4 | CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1ccc(NC(=O)Nc2ccccc2C)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O | 10.1021/jm00001a027 | |||
| 10556460 | 209197 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 677 | 10 | 0 | 6 | 7.4 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(Cc4ccccc4)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
| CHEMBL89953 | 209197 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 677 | 10 | 0 | 6 | 7.4 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(Cc4ccccc4)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
| 14444013 | 106735 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 692 | 17 | 7 | 7 | 2.7 | CC(C)C[C@H](CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm00123a003 | |||
| CHEMBL3143394 | 106735 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 692 | 17 | 7 | 7 | 2.7 | CC(C)C[C@H](CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm00123a003 | |||
| 44341429 | 110515 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 498 | 13 | 2 | 3 | 6.3 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc2ccccc2n1 | 10.1021/jm00116a002 | |||
| CHEMBL324652 | 110515 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 498 | 13 | 2 | 3 | 6.3 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc2ccccc2n1 | 10.1021/jm00116a002 | |||
| 15167797 | 31664 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 403 | 5 | 2 | 4 | 4.4 | O=C(NCC1CNc2ccccc2C(c2ccccc2F)=N1)OCc1ccccc1 | 10.1021/jm00163a069 | |||
| CHEMBL140495 | 31664 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 403 | 5 | 2 | 4 | 4.4 | O=C(NCC1CNc2ccccc2C(c2ccccc2F)=N1)OCc1ccccc1 | 10.1021/jm00163a069 | |||
| 20190196 | 31796 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 388 | 4 | 1 | 4 | 3.3 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)c1cccnc1 | 10.1021/jm00163a069 | |||
| CHEMBL140620 | 31796 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 388 | 4 | 1 | 4 | 3.3 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)c1cccnc1 | 10.1021/jm00163a069 | |||
| 15614749 | 32253 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 393 | 4 | 2 | 4 | 3.5 | O=C(NCC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccsc1 | 10.1021/jm00163a069 | |||
| CHEMBL140984 | 32253 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 393 | 4 | 2 | 4 | 3.5 | O=C(NCC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccsc1 | 10.1021/jm00163a069 | |||
| 44359880 | 32337 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 428 | 7 | 2 | 5 | 2.4 | CC(=O)NCSCC(=O)NCC1CN=C(c2ccccc2F)c2ccccc2N1C | 10.1021/jm00163a069 | |||
| CHEMBL141048 | 32337 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 428 | 7 | 2 | 5 | 2.4 | CC(=O)NCSCC(=O)NCC1CN=C(c2ccccc2F)c2ccccc2N1C | 10.1021/jm00163a069 | |||
| 19766234 | 32344 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 427 | 4 | 1 | 3 | 5.6 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNc1cccc(C(F)(F)F)c1 | 10.1021/jm00163a069 | |||
| CHEMBL141051 | 32344 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 427 | 4 | 1 | 3 | 5.6 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNc1cccc(C(F)(F)F)c1 | 10.1021/jm00163a069 | |||
| 20063245 | 115406 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 417 | 5 | 2 | 4 | 3.9 | O=C(NCC1N=C(c2ccccc2F)c2ccccc2NC1=O)OCc1ccccc1 | 10.1021/jm00163a069 | |||
| CHEMBL334933 | 115406 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 417 | 5 | 2 | 4 | 3.9 | O=C(NCC1N=C(c2ccccc2F)c2ccccc2NC1=O)OCc1ccccc1 | 10.1021/jm00163a069 | |||
| 44359840 | 165543 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 395 | 4 | 2 | 5 | 3.5 | O=C1Nc2ccccc2C(c2ccccc2F)=NC1CNc1cnc(Cl)cn1 | 10.1021/jm00163a069 | |||
| CHEMBL423918 | 165543 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 395 | 4 | 2 | 5 | 3.5 | O=C1Nc2ccccc2C(c2ccccc2F)=NC1CNc1cnc(Cl)cn1 | 10.1021/jm00163a069 | |||
| 44370505 | 51295 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 543 | 10 | 2 | 4 | 6.3 | O=C(CC[C@H](NC(=O)c1cc2ccccc2[nH]1)C(=O)N(C1CCCCC1)C1CCCCC1)OCc1ccccc1 | 10.1021/jm00164a020 | |||
| CHEMBL158078 | 51295 | None | 0 | Human | Binding | pIC50 | = | 4 | 4.0 | - | 0 | ChEMBL | 543 | 10 | 2 | 4 | 6.3 | O=C(CC[C@H](NC(=O)c1cc2ccccc2[nH]1)C(=O)N(C1CCCCC1)C1CCCCC1)OCc1ccccc1 | 10.1021/jm00164a020 | |||
| 44280270 | 99272 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 601 | 10 | 2 | 4 | 5.2 | CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@H](Cc1ccccc1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL281560 | 99272 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 601 | 10 | 2 | 4 | 5.2 | CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@H](Cc1ccccc1)C(=O)O | 10.1021/jm950372w | |||
| 44280193 | 103186 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 672 | 13 | 3 | 5 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL30784 | 103186 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 672 | 13 | 3 | 5 | 5.1 | CN(Cc1ccccc1)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 10474221 | 16856 | None | 0 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 368 | 8 | 3 | 3 | 2.9 | CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 | 10.1021/jm00079a003 | |||
| CHEMBL124822 | 16856 | None | 0 | Rat | Binding | pIC50 | = | 5 | 5.0 | - | 0 | ChEMBL | 368 | 8 | 3 | 3 | 2.9 | CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 | 10.1021/jm00079a003 | |||
| 44281084 | 112755 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 497 | 8 | 3 | 4 | 3.3 | O=C(O)CNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL33043 | 112755 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 497 | 8 | 3 | 4 | 3.3 | O=C(O)CNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 10482726 | 26149 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 551 | 7 | 3 | 4 | 5.0 | O=C(CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21)NCc1ccccc1 | 10.1021/jm00078a018 | |||
| CHEMBL135638 | 26149 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 551 | 7 | 3 | 4 | 5.0 | O=C(CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21)NCc1ccccc1 | 10.1021/jm00078a018 | |||
| 44349278 | 16613 | None | 0 | Rat | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 388 | 10 | 3 | 3 | 3.3 | CCCCCNC(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00079a003 | |||
| CHEMBL124090 | 16613 | None | 0 | Rat | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 388 | 10 | 3 | 3 | 3.3 | CCCCCNC(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00079a003 | |||
| 44349412 | 16872 | None | 0 | Rat | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 396 | 12 | 3 | 3 | 3.6 | CCCCC(CC)CNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 | 10.1021/jm00079a003 | |||
| CHEMBL124917 | 16872 | None | 0 | Rat | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 396 | 12 | 3 | 3 | 3.6 | CCCCC(CC)CNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 | 10.1021/jm00079a003 | |||
| 44382371 | 120565 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 436 | 5 | 2 | 4 | 2.8 | COc1cccc(NC(=O)N[C@@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
| CHEMBL354442 | 120565 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 436 | 5 | 2 | 4 | 2.8 | COc1cccc(NC(=O)N[C@@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
| 44281292 | 114858 | None | 0 | Mouse | Binding | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 816 | 17 | 5 | 9 | 5.0 | CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCNC(=O)CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
| CHEMBL33398 | 114858 | None | 0 | Mouse | Binding | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 816 | 17 | 5 | 9 | 5.0 | CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCNC(=O)CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
| 44357198 | 115302 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 478 | 6 | 4 | 5 | 3.0 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(C[C@@H](O)CO)C1=O | 10.1021/jm00078a018 | |||
| CHEMBL334735 | 115302 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 478 | 6 | 4 | 5 | 3.0 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(C[C@@H](O)CO)C1=O | 10.1021/jm00078a018 | |||
| 10603714 | 156609 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 605 | 8 | 1 | 5 | 6.0 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4c(F)cccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
| CHEMBL406790 | 156609 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 605 | 8 | 1 | 5 | 6.0 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4c(F)cccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
| 44349325 | 168651 | None | 0 | Rat | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 465 | 7 | 3 | 4 | 3.1 | O=C(O)CCC(NC(=O)c1cccc(Br)c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
| CHEMBL435587 | 168651 | None | 0 | Rat | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 465 | 7 | 3 | 4 | 3.1 | O=C(O)CCC(NC(=O)c1cccc(Br)c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
| 44280380 | 99894 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 553 | 11 | 3 | 4 | 4.8 | CCCCC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL285657 | 99894 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 553 | 11 | 3 | 4 | 4.8 | CCCCC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O | 10.1021/jm950372w | |||
| 44283087 | 120888 | None | 0 | Mouse | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 500 | 8 | 2 | 4 | 5.8 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)OCCc1ccccc1 | 10.1021/jm00086a017 | |||
| CHEMBL35580 | 120888 | None | 0 | Mouse | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 500 | 8 | 2 | 4 | 5.8 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)OCCc1ccccc1 | 10.1021/jm00086a017 | |||
| 10249484 | 22662 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 385 | 3 | 2 | 4 | 3.0 | CN1C(=O)C(NC(=O)Nc2ccncc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| CHEMBL132699 | 22662 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 385 | 3 | 2 | 4 | 3.0 | CN1C(=O)C(NC(=O)Nc2ccncc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| 10646538 | 97420 | None | 0 | Mouse | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 435 | 6 | 3 | 6 | 4.1 | CC(C)Oc1cccc(-n2c(NNC(=O)NC3CCCCC3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
| CHEMBL269606 | 97420 | None | 0 | Mouse | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 435 | 6 | 3 | 6 | 4.1 | CC(C)Oc1cccc(-n2c(NNC(=O)NC3CCCCC3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
| 44280244 | 13231 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 695 | 12 | 4 | 6 | 5.6 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2cccnc12 | 10.1021/jm950372w | |||
| CHEMBL1191257 | 13231 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 695 | 12 | 4 | 6 | 5.6 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2cccnc12 | 10.1021/jm950372w | |||
| CHEMBL542330 | 13231 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 695 | 12 | 4 | 6 | 5.6 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2cccnc12 | 10.1021/jm950372w | |||
| 44283055 | 99810 | None | 0 | Mouse | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 515 | 9 | 4 | 4 | 4.4 | O=C(NC(Cc1c[nH]c2ccccc12)C(=O)NC(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
| CHEMBL285049 | 99810 | None | 0 | Mouse | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 515 | 9 | 4 | 4 | 4.4 | O=C(NC(Cc1c[nH]c2ccccc12)C(=O)NC(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
| 44283150 | 165340 | None | 0 | Mouse | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 529 | 9 | 3 | 4 | 4.7 | CN(C(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(CO)Cc1ccccc1 | 10.1021/jm00086a017 | |||
| CHEMBL422941 | 165340 | None | 0 | Mouse | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 529 | 9 | 3 | 4 | 4.7 | CN(C(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(CO)Cc1ccccc1 | 10.1021/jm00086a017 | |||
| 44283514 | 170720 | None | 0 | Mouse | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 585 | 12 | 3 | 4 | 6.0 | CC(Cc1c[nH]c2ccccc12)(CN(CCc1ccccc1)C(=O)CCC(=O)O)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
| CHEMBL445094 | 170720 | None | 0 | Mouse | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 585 | 12 | 3 | 4 | 6.0 | CC(Cc1c[nH]c2ccccc12)(CN(CCc1ccccc1)C(=O)CCC(=O)O)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
| 10738855 | 209069 | None | 0 | Mouse | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 385 | 4 | 3 | 5 | 3.8 | Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccccc2)c1 | 10.1021/jm970373j | |||
| CHEMBL8905 | 209069 | None | 0 | Mouse | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 385 | 4 | 3 | 5 | 3.8 | Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccccc2)c1 | 10.1021/jm970373j | |||
| 44382038 | 120524 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 420 | 4 | 2 | 3 | 3.1 | Cc1cccc(NC(=O)N[C@@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
| CHEMBL354040 | 120524 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 420 | 4 | 2 | 3 | 3.1 | Cc1cccc(NC(=O)N[C@@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
| 443375 | 210065 | None | 33 | Rat | Binding | pIC50 | = | 6.0 | 6.0 | -389 | 5 | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/0960-894X(96)00160-6 | |||
| CHEMBL9506 | 210065 | None | 33 | Rat | Binding | pIC50 | = | 6.0 | 6.0 | -389 | 5 | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/0960-894X(96)00160-6 | |||
| CHEMBL408083 | 215158 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | -3 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
| 16100406 | 83256 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | -281 | 4 | ChEMBL | 1132 | 28 | 13 | 13 | 1.7 | CCCC[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
| CHEMBL218600 | 83256 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | -281 | 4 | ChEMBL | 1132 | 28 | 13 | 13 | 1.7 | CCCC[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
| 10551234 | 96994 | None | 0 | Mouse | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 443 | 6 | 3 | 6 | 4.6 | Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 | 10.1021/jm970373j | |||
| CHEMBL266120 | 96994 | None | 0 | Mouse | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 443 | 6 | 3 | 6 | 4.6 | Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 | 10.1021/jm970373j | |||
| 10455303 | 115284 | None | 9 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 429 | 4 | 2 | 5 | 3.6 | CN1C(=O)C(NC(=O)Nc2cccc([N+](=O)[O-])c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| CHEMBL334592 | 115284 | None | 9 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 429 | 4 | 2 | 5 | 3.6 | CN1C(=O)C(NC(=O)Nc2cccc([N+](=O)[O-])c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| 10005779 | 116728 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 489 | 6 | 3 | 4 | 3.8 | CCNC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| CHEMBL337065 | 116728 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 489 | 6 | 3 | 4 | 3.8 | CCNC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| 44280996 | 99798 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 745 | 14 | 4 | 8 | 5.4 | CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
| CHEMBL284976 | 99798 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 745 | 14 | 4 | 8 | 5.4 | CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
| 11555184 | 166127 | None | 0 | Dog | Binding | pIC50 | = | 8.0 | 8.0 | - | 3 | ChEMBL | 503 | 7 | 3 | 3 | 7.0 | Cc1ccc(NC(=O)c2[nH]c(C3(C)CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O | 10.1021/jm0490686 | |||
| CHEMBL425574 | 166127 | None | 0 | Dog | Binding | pIC50 | = | 8.0 | 8.0 | - | 3 | ChEMBL | 503 | 7 | 3 | 3 | 7.0 | Cc1ccc(NC(=O)c2[nH]c(C3(C)CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O | 10.1021/jm0490686 | |||
| 145990693 | 167069 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 465 | 6 | 3 | 6 | 4.8 | CCOc1ccc(-n2c(NNC(=S)Nc3ccc(Cl)cc3)nc3ccccc3c2=O)cc1 | 10.1039/C7MD00171A | |||
| CHEMBL4287572 | 167069 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 465 | 6 | 3 | 6 | 4.8 | CCOc1ccc(-n2c(NNC(=S)Nc3ccc(Cl)cc3)nc3ccccc3c2=O)cc1 | 10.1039/C7MD00171A | |||
| 44333305 | 5053 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 502 | 4 | 2 | 5 | 3.6 | CCCN1C(=O)C(NC(=O)Nc2cccc(C(F)(F)F)c2)N=C(N2CCN(C)CC2)c2ccccc21 | 10.1016/0960-894X(95)00530-0 | |||
| CHEMBL105273 | 5053 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 502 | 4 | 2 | 5 | 3.6 | CCCN1C(=O)C(NC(=O)Nc2cccc(C(F)(F)F)c2)N=C(N2CCN(C)CC2)c2ccccc21 | 10.1016/0960-894X(95)00530-0 | |||
| 44210424 | 119282 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 423 | 4 | 2 | 4 | 3.8 | Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
| CHEMBL34335 | 119282 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 423 | 4 | 2 | 4 | 3.8 | Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
| 73351320 | 106202 | None | 0 | Mouse | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 681 | 12 | 5 | 5 | 5.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCNC(=O)C(F)(F)F)c1ccccc1 | 10.1021/jm00092a007 | |||
| CHEMBL313559 | 106202 | None | 0 | Mouse | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 681 | 12 | 5 | 5 | 5.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCNC(=O)C(F)(F)F)c1ccccc1 | 10.1021/jm00092a007 | |||
| 14843036 | 100215 | None | 0 | Mouse | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 413 | 5 | 1 | 4 | 4.8 | COc1cccc(-n2c(CCc3c[nH]c4ccc(F)cc34)nc3ccccc3c2=O)c1 | 10.1021/jm00108a040 | |||
| CHEMBL287914 | 100215 | None | 0 | Mouse | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 413 | 5 | 1 | 4 | 4.8 | COc1cccc(-n2c(CCc3c[nH]c4ccc(F)cc34)nc3ccccc3c2=O)c1 | 10.1021/jm00108a040 | |||
| 14843048 | 117309 | None | 0 | Mouse | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 501 | 6 | 1 | 4 | 6.2 | CC(C)Oc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 | 10.1021/jm00108a040 | |||
| CHEMBL33948 | 117309 | None | 0 | Mouse | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 501 | 6 | 1 | 4 | 6.2 | CC(C)Oc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 | 10.1021/jm00108a040 | |||
| 44210424 | 119282 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 423 | 4 | 2 | 4 | 3.8 | Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00234-K | |||
| CHEMBL34335 | 119282 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 423 | 4 | 2 | 4 | 3.8 | Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00234-K | |||
| 44279809 | 99021 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 785 | 18 | 4 | 7 | 6.4 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL279778 | 99021 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 785 | 18 | 4 | 7 | 6.4 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL319814 | 213682 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||||
| 15689734 | 106665 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 854 | 21 | 9 | 9 | 3.5 | CC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 | 10.1021/jm960509y | |||
| CHEMBL3142899 | 106665 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 854 | 21 | 9 | 9 | 3.5 | CC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 | 10.1021/jm960509y | |||
| CHEMBL319814 | 213682 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00173a006 | |||||
| 44381201 | 161770 | None | 0 | Rat | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 1062 | 29 | 9 | 12 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)CCc1ccccc1 | 10.1016/S0960-894X(00)80679-4 | |||
| CHEMBL413186 | 161770 | None | 0 | Rat | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 1062 | 29 | 9 | 12 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)CCc1ccccc1 | 10.1016/S0960-894X(00)80679-4 | |||
| 14843041 | 125109 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 471 | 5 | 1 | 3 | 6.0 | CCc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 | 10.1021/jm00108a040 | |||
| CHEMBL36436 | 125109 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 471 | 5 | 1 | 3 | 6.0 | CCc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 | 10.1021/jm00108a040 | |||
| 73354298 | 96724 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 1017 | 29 | 9 | 10 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| CHEMBL263876 | 96724 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 1017 | 29 | 9 | 10 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| 10031700 | 12194 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 486 | 7 | 2 | 4 | 3.7 | COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC[N+](C)(C)C)C2=O)c1 | 10.1021/jm00078a018 | |||
| CHEMBL1184246 | 12194 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 486 | 7 | 2 | 4 | 3.7 | COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC[N+](C)(C)C)C2=O)c1 | 10.1021/jm00078a018 | |||
| CHEMBL340975 | 12194 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 486 | 7 | 2 | 4 | 3.7 | COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC[N+](C)(C)C)C2=O)c1 | 10.1021/jm00078a018 | |||
| 10070678 | 120819 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| CHEMBL355092 | 120819 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| 44334452 | 4561 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 497 | 9 | 2 | 3 | 5.6 | Cc1cccc(NC(=O)N[C@H](CCCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
| CHEMBL102461 | 4561 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 497 | 9 | 2 | 3 | 5.6 | Cc1cccc(NC(=O)N[C@H](CCCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
| 15689738 | 106659 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 862 | 20 | 9 | 8 | 4.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
| CHEMBL3142705 | 106659 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 862 | 20 | 9 | 8 | 4.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
| 10320031 | 77854 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 421 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00121a004 | |||
| CHEMBL2092868 | 77854 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 421 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00121a004 | |||
| 14208307 | 77853 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 513 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@@H](NC(=O)c2ccccc2I)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| CHEMBL2092867 | 77853 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 513 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@@H](NC(=O)c2ccccc2I)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| 14208216 | 102758 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 393 | 3 | 1 | 4 | 3.5 | CN1C(=O)C(NC(=O)c2ccsc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| CHEMBL304768 | 102758 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 393 | 3 | 1 | 4 | 3.5 | CN1C(=O)C(NC(=O)c2ccsc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| 14208210 | 206661 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 413 | 3 | 2 | 4 | 4.1 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2ccccc2o1 | 10.1021/jm00120a002 | |||
| CHEMBL70856 | 206661 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 413 | 3 | 2 | 4 | 4.1 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2ccccc2o1 | 10.1021/jm00120a002 | |||
| 44375135 | 52774 | None | 0 | Mouse | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 520 | 12 | 6 | 7 | 2.7 | O=C(O)CCCNS(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 | 10.1016/s0960-894x(01)00044-0 | |||
| CHEMBL159469 | 52774 | None | 0 | Mouse | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 520 | 12 | 6 | 7 | 2.7 | O=C(O)CCCNS(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 | 10.1016/s0960-894x(01)00044-0 | |||
| 15104606 | 9459 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 497 | 13 | 2 | 2 | 6.9 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc2ccccc2c1 | 10.1021/jm00116a002 | |||
| CHEMBL111837 | 9459 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 497 | 13 | 2 | 2 | 6.9 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc2ccccc2c1 | 10.1021/jm00116a002 | |||
| 10364355 | 27959 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 412 | 4 | 2 | 3 | 3.9 | C[C@H](NC(=O)NC1N=C(c2ccccc2)c2ccccc2N(C)C1=O)c1ccccc1 | 10.1021/jm00078a018 | |||
| CHEMBL137208 | 27959 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 412 | 4 | 2 | 3 | 3.9 | C[C@H](NC(=O)NC1N=C(c2ccccc2)c2ccccc2N(C)C1=O)c1ccccc1 | 10.1021/jm00078a018 | |||
| 15200522 | 120532 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 422 | 4 | 2 | 3 | 3.7 | CN1C(=O)C(NC(=O)Cc2c[nH]c3ccccc23)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
| CHEMBL354126 | 120532 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 422 | 4 | 2 | 3 | 3.7 | CN1C(=O)C(NC(=O)Cc2c[nH]c3ccccc23)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
| 44382008 | 59067 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 403 | 3 | 1 | 3 | 3.9 | CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80684-8 | |||
| CHEMBL169438 | 59067 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 403 | 3 | 1 | 3 | 3.9 | CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80684-8 | |||
| 44280502 | 99440 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 672 | 14 | 4 | 5 | 4.8 | O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCc1ccccc1 | 10.1021/jm950372w | |||
| CHEMBL282639 | 99440 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 672 | 14 | 4 | 5 | 4.8 | O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCc1ccccc1 | 10.1021/jm950372w | |||
| 10253714 | 25502 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 460 | 4 | 2 | 3 | 5.3 | CN1C(=O)C(NC(=O)Nc2cccc(-c3ccccc3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| CHEMBL135060 | 25502 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 460 | 4 | 2 | 3 | 5.3 | CN1C(=O)C(NC(=O)Nc2cccc(-c3ccccc3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| 10722103 | 111537 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 588 | 8 | 1 | 6 | 5.3 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ncccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
| CHEMBL327656 | 111537 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 588 | 8 | 1 | 6 | 5.3 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ncccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
| 44327456 | 210301 | None | 0 | Mouse | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 585 | 11 | 2 | 5 | 5.7 | COC(=O)CCN(CCc1ccccc1)C(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1016/S0960-894X(01)80769-1 | |||
| CHEMBL96401 | 210301 | None | 0 | Mouse | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 585 | 11 | 2 | 5 | 5.7 | COC(=O)CCN(CCc1ccccc1)C(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1016/S0960-894X(01)80769-1 | |||
| 155560670 | 175196 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 1886 | 72 | 17 | 23 | 4.2 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4568746 | 175196 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 1886 | 72 | 17 | 23 | 4.2 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 44279810 | 103899 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 757 | 16 | 4 | 7 | 5.7 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL30917 | 103899 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 757 | 16 | 4 | 7 | 5.7 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
| 73354298 | 96724 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 1017 | 29 | 9 | 10 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| CHEMBL263876 | 96724 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 1017 | 29 | 9 | 10 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| 10074366 | 120662 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL3349028 | 120662 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL3545866 | 120662 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| 44329518 | 210793 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 560 | 6 | 3 | 3 | 6.2 | Cc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2ccc(Cl)cc2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 | 10.1016/S0960-894X(01)80832-5 | |||
| CHEMBL99311 | 210793 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 560 | 6 | 3 | 3 | 6.2 | Cc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2ccc(Cl)cc2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 | 10.1016/S0960-894X(01)80832-5 | |||
| 10622006 | 209222 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 419 | 4 | 3 | 5 | 4.5 | Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)c1 | 10.1021/jm970373j | |||
| CHEMBL9010 | 209222 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 419 | 4 | 3 | 5 | 4.5 | Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)c1 | 10.1021/jm970373j | |||
| 44382327 | 59375 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 436 | 5 | 2 | 4 | 2.8 | COc1cccc(NC(=O)N[C@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
| CHEMBL170777 | 59375 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 436 | 5 | 2 | 4 | 2.8 | COc1cccc(NC(=O)N[C@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
| 44283515 | 100229 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 516 | 8 | 2 | 4 | 6.5 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)SCCc1ccccc1 | 10.1021/jm00086a017 | |||
| CHEMBL288038 | 100229 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 516 | 8 | 2 | 4 | 6.5 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)SCCc1ccccc1 | 10.1021/jm00086a017 | |||
| 44280000 | 103308 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 525 | 10 | 3 | 4 | 4.0 | O=C(O)CCCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL30844 | 103308 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 525 | 10 | 3 | 4 | 4.0 | O=C(O)CCCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 10319892 | 59108 | None | 1 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00121a004 | |||
| CHEMBL169661 | 59108 | None | 1 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00121a004 | |||
| CHEMBL2386884 | 212855 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | None | None | None | C#CCCC(=O)NCCCC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cn(CC(=O)NCCCC(CCCNC(=O)Cn2cc(NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCC)N(C)C(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCCNC(=O)CCC#C)NC(C)=O)nn2)(NC(=O)CNC(=O)Cn2cc(NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCC)N(C)C(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCCNC(=O)CCC#C)NC(C)=O)nn2)C(=O)NCCC(N)=O)nn1 | 10.1016/j.bmcl.2013.02.022 | |||||
| 10010811 | 106664 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 854 | 21 | 9 | 9 | 3.5 | CC(=O)c1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm960509y | |||
| CHEMBL3142898 | 106664 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 854 | 21 | 9 | 9 | 3.5 | CC(=O)c1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm960509y | |||
| 73349791 | 208265 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 664 | 13 | 5 | 6 | 5.2 | CCOP(=O)(O)CC(=O)N[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 | 10.1021/jm00092a007 | |||
| CHEMBL83244 | 208265 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 664 | 13 | 5 | 6 | 5.2 | CCOP(=O)(O)CC(=O)N[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 | 10.1021/jm00092a007 | |||
| 73348230 | 208820 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 634 | 11 | 5 | 5 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CP(C)(=O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
| CHEMBL87470 | 208820 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 634 | 11 | 5 | 5 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CP(C)(=O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
| 73346731 | 81577 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 1017 | 29 | 9 | 10 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| CHEMBL216079 | 81577 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 1017 | 29 | 9 | 10 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| 10647112 | 163518 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 447 | 3 | 3 | 4 | 4.1 | Cc1cccc(NC(=O)N[C@@H]2N=C([C@H]3CCC(C)(C)CCN3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm9608523 | |||
| CHEMBL419663 | 163518 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 447 | 3 | 3 | 4 | 4.1 | Cc1cccc(NC(=O)N[C@@H]2N=C([C@H]3CCC(C)(C)CCN3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm9608523 | |||
| 9896825 | 103032 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 742 | 14 | 6 | 10 | 2.9 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL30656 | 103032 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 742 | 14 | 6 | 10 | 2.9 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| 10319892 | 59108 | None | 1 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
| CHEMBL169661 | 59108 | None | 1 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
| 9805700 | 119219 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 492 | 6 | 3 | 4 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CCCCCC1 | 10.1021/jm970065l | |||
| CHEMBL342932 | 119219 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 492 | 6 | 3 | 4 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CCCCCC1 | 10.1021/jm970065l | |||
| 19766169 | 165661 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 443 | 4 | 2 | 4 | 4.2 | CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)CCc2ccccc21 | 10.1016/S0960-894X(00)80683-6 | |||
| CHEMBL424211 | 165661 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 443 | 4 | 2 | 4 | 4.2 | CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)CCc2ccccc21 | 10.1016/S0960-894X(00)80683-6 | |||
| 14208237 | 206671 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 498 | 6 | 2 | 5 | 3.8 | CCOC(=O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| CHEMBL70883 | 206671 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 498 | 6 | 2 | 5 | 3.8 | CCOC(=O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| 14991586 | 100693 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 838 | 21 | 7 | 9 | 3.0 | CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1cccnc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
| CHEMBL292071 | 100693 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 838 | 21 | 7 | 9 | 3.0 | CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1cccnc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
| 44334248 | 4682 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 528 | 8 | 3 | 5 | 4.9 | Cc1cccc(NC(=O)N[C@H](COC(=O)Nc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
| CHEMBL103312 | 4682 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 528 | 8 | 3 | 5 | 4.9 | Cc1cccc(NC(=O)N[C@H](COC(=O)Nc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
| CHEMBL262767 | 213007 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | None | None | None | Cc1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm00113a023 | |||||
| 44382486 | 59438 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 518 | 11 | 4 | 4 | 2.8 | CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O | 10.1016/S0960-894X(01)80253-5 | |||
| CHEMBL171051 | 59438 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 518 | 11 | 4 | 4 | 2.8 | CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O | 10.1016/S0960-894X(01)80253-5 | |||
| 11803697 | 106672 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 857 | 21 | 9 | 10 | 3.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc([N+](=O)[O-])c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm960509y | |||
| 136898911 | 106672 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 857 | 21 | 9 | 10 | 3.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc([N+](=O)[O-])c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm960509y | |||
| CHEMBL3142912 | 106672 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 857 | 21 | 9 | 10 | 3.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc([N+](=O)[O-])c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm960509y | |||
| CHEMBL262767 | 213007 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | None | None | None | Cc1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm960509y | |||||
| CHEMBL262767 | 213007 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | None | None | None | Cc1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm00173a006 | |||||
| 44311939 | 206953 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 530 | 6 | 2 | 5 | 4.2 | CN1C(=O)C(NC(=O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| CHEMBL72526 | 206953 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 530 | 6 | 2 | 5 | 4.2 | CN1C(=O)C(NC(=O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| 44377790 | 120046 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 678 | 16 | 7 | 7 | 2.5 | CC(C)C[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)C(Cc1ccccc1)C(N)=O)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm00388a002 | |||
| CHEMBL349888 | 120046 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 678 | 16 | 7 | 7 | 2.5 | CC(C)C[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)C(Cc1ccccc1)C(N)=O)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm00388a002 | |||
| 73346732 | 170024 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 1017 | 29 | 9 | 10 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| CHEMBL444113 | 170024 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 1017 | 29 | 9 | 10 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| 11742520 | 29634 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 414 | 4 | 2 | 4 | 3.7 | COc1ccccc1NC(=O)NC1N=C(c2ccccc2)c2ccccc2N(C)C1=O | 10.1021/jm00078a018 | |||
| CHEMBL138592 | 29634 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 414 | 4 | 2 | 4 | 3.7 | COc1ccccc1NC(=O)NC1N=C(c2ccccc2)c2ccccc2N(C)C1=O | 10.1021/jm00078a018 | |||
| 10094138 | 168433 | None | 9 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 429 | 4 | 2 | 5 | 3.6 | CN1C(=O)C(NC(=O)Nc2ccccc2[N+](=O)[O-])N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| CHEMBL434255 | 168433 | None | 9 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 429 | 4 | 2 | 5 | 3.6 | CN1C(=O)C(NC(=O)Nc2ccccc2[N+](=O)[O-])N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| 14991569 | 98853 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 863 | 20 | 9 | 9 | 3.7 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccc2cc(O)ccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
| CHEMBL278447 | 98853 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 863 | 20 | 9 | 9 | 3.7 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccc2cc(O)ccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
| 44349011 | 116924 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 373 | 8 | 4 | 3 | 2.7 | CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00079a003 | |||
| CHEMBL338134 | 116924 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 373 | 8 | 4 | 3 | 2.7 | CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00079a003 | |||
| 44349070 | 164586 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 421 | 7 | 3 | 4 | 3.0 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
| CHEMBL421438 | 164586 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 421 | 7 | 3 | 4 | 3.0 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
| 13822916 | 189835 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 421 | 3 | 1 | 4 | 5.3 | Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=N[C@@H]2Cc1c[nH]c2ccccc12 | 10.1021/jm00396a028 | |||
| CHEMBL51569 | 189835 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 421 | 3 | 1 | 4 | 5.3 | Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=N[C@@H]2Cc1c[nH]c2ccccc12 | 10.1021/jm00396a028 | |||
| 44381202 | 161925 | None | 0 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 1139 | 31 | 10 | 12 | 4.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NC(Cc1ccccc1)Cc1ccccc1 | 10.1016/S0960-894X(00)80679-4 | |||
| CHEMBL414523 | 161925 | None | 0 | Rat | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 1139 | 31 | 10 | 12 | 4.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NC(Cc1ccccc1)Cc1ccccc1 | 10.1016/S0960-894X(00)80679-4 | |||
| 15104594 | 10125 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 498 | 13 | 2 | 3 | 6.3 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
| CHEMBL115656 | 10125 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 498 | 13 | 2 | 3 | 6.3 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00116a002 | |||
| 11729474 | 4673 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 420 | 2 | 2 | 5 | 2.1 | Cc1cccc(NC(=O)NC2N=C(N3CCN(C)CC3)c3ccccc3N(C)C2=O)c1 | 10.1016/0960-894X(95)00530-0 | |||
| CHEMBL103229 | 4673 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 420 | 2 | 2 | 5 | 2.1 | Cc1cccc(NC(=O)NC2N=C(N3CCN(C)CC3)c3ccccc3N(C)C2=O)c1 | 10.1016/0960-894X(95)00530-0 | |||
| 44396746 | 127128 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 637 | 8 | 2 | 6 | 5.7 | C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 | 10.1021/jm0498755 | |||
| CHEMBL365620 | 127128 | None | 0 | Rat | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 637 | 8 | 2 | 6 | 5.7 | C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 | 10.1021/jm0498755 | |||
| 10839347 | 30269 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 507 | 7 | 4 | 4 | 4.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1(CO)CCCCC1 | 10.1021/jm970065l | |||
| CHEMBL139101 | 30269 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 507 | 7 | 4 | 4 | 4.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1(CO)CCCCC1 | 10.1021/jm970065l | |||
| 44280992 | 100173 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 678 | 12 | 4 | 5 | 5.5 | CC1(C)CCC(NC(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL287564 | 100173 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 678 | 12 | 4 | 5 | 5.5 | CC1(C)CCC(NC(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 | 10.1021/jm950372w | |||
| 44283081 | 99925 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 500 | 9 | 3 | 3 | 6.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(O)CCCc1ccccc1 | 10.1021/jm00086a017 | |||
| CHEMBL2112071 | 99925 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 500 | 9 | 3 | 3 | 6.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(O)CCCc1ccccc1 | 10.1021/jm00086a017 | |||
| CHEMBL285880 | 99925 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 500 | 9 | 3 | 3 | 6.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(O)CCCc1ccccc1 | 10.1021/jm00086a017 | |||
| 10761732 | 75973 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 371 | 4 | 3 | 5 | 3.5 | O=C(NNc1nc2ccccc2c(=O)n1-c1ccccc1)Nc1ccccc1 | 10.1021/jm970373j | |||
| CHEMBL2051984 | 75973 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 371 | 4 | 3 | 5 | 3.5 | O=C(NNc1nc2ccccc2c(=O)n1-c1ccccc1)Nc1ccccc1 | 10.1021/jm970373j | |||
| 44283246 | 100016 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 527 | 8 | 2 | 4 | 6.8 | O=C(NC(Cc1c[nH]c2ccccc12)C1CN=C(CCc2ccccc2)S1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
| CHEMBL286442 | 100016 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 527 | 8 | 2 | 4 | 6.8 | O=C(NC(Cc1c[nH]c2ccccc12)C1CN=C(CCc2ccccc2)S1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
| 44303515 | 102148 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 571 | 9 | 2 | 5 | 5.3 | CN(C)C(=O)c1oc2ccccc2c1CC(C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
| CHEMBL302194 | 102148 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 571 | 9 | 2 | 5 | 5.3 | CN(C)C(=O)c1oc2ccccc2c1CC(C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
| 49798104 | 10849 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | 7 | 3 | ChEMBL | 1381 | 39 | 14 | 13 | 3.5 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2010.05.078 | |||
| CHEMBL1172244 | 10849 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | 7 | 3 | ChEMBL | 1381 | 39 | 14 | 13 | 3.5 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2010.05.078 | |||
| CHEMBL1172249 | 211041 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | -16 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2010.05.078 | |||||
| CHEMBL1172252 | 211043 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | -173 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2010.05.078 | |||||
| CHEMBL1172253 | 211044 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | -851 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2010.05.078 | |||||
| 44283152 | 99908 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 501 | 10 | 4 | 4 | 4.8 | O=C(NC(CNC(CO)Cc1ccccc1)Cc1c[nH]c2ccccc12)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
| CHEMBL285762 | 99908 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 501 | 10 | 4 | 4 | 4.8 | O=C(NC(CNC(CO)Cc1ccccc1)Cc1c[nH]c2ccccc12)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
| 44381892 | 12280 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 510 | 9 | 2 | 4 | 3.7 | CN(C)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
| CHEMBL1184772 | 12280 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 510 | 9 | 2 | 4 | 3.7 | CN(C)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
| CHEMBL368133 | 12280 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 510 | 9 | 2 | 4 | 3.7 | CN(C)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
| 44279985 | 103158 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 511 | 8 | 3 | 4 | 3.6 | CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL30764 | 103158 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 511 | 8 | 3 | 4 | 3.6 | CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O | 10.1021/jm950372w | |||
| 11755707 | 57539 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 500 | 8 | 2 | 7 | 4.7 | CCOC(=O)c1cccc(NC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 | 10.1016/S0960-894X(97)00108-X | |||
| CHEMBL166168 | 57539 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 500 | 8 | 2 | 7 | 4.7 | CCOC(=O)c1cccc(NC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 | 10.1016/S0960-894X(97)00108-X | |||
| 10074366 | 120662 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL3349028 | 120662 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL3545866 | 120662 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| 44396624 | 123953 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 559 | 7 | 2 | 6 | 4.7 | C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC(C)(C)C)C12 | 10.1021/jm0498755 | |||
| CHEMBL362769 | 123953 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 559 | 7 | 2 | 6 | 4.7 | C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC(C)(C)C)C12 | 10.1021/jm0498755 | |||
| 155514432 | 169968 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 2121 | 86 | 19 | 27 | 2.3 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)[C@H](CCCCN)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4440303 | 169968 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 2121 | 86 | 19 | 27 | 2.3 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)[C@H](CCCCN)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 10531430 | 112410 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 587 | 8 | 1 | 5 | 5.9 | COc1ccccc1N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)C(C)C | 10.1021/jm970265x | |||
| CHEMBL329407 | 112410 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 587 | 8 | 1 | 5 | 5.9 | COc1ccccc1N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)C(C)C | 10.1021/jm970265x | |||
| 10349938 | 163014 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 722 | 14 | 4 | 6 | 6.7 | CC(Cc1c[nH]c2ccc(F)cc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)OCc1ccccc1)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
| CHEMBL417412 | 163014 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 722 | 14 | 4 | 6 | 6.7 | CC(Cc1c[nH]c2ccc(F)cc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)OCc1ccccc1)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
| 44279938 | 162720 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 637 | 10 | 3 | 4 | 6.0 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccc2ccccc2c1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL416944 | 162720 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 637 | 10 | 3 | 4 | 6.0 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccc2ccccc2c1)C(=O)O | 10.1021/jm950372w | |||
| 44386117 | 131419 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 541 | 9 | 4 | 4 | 5.3 | O=C(O)C[C@H](Cc1ccccc1)NC(=O)/C(=C/c1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1016/S0960-894X(00)80273-5 | |||
| CHEMBL368803 | 131419 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 541 | 9 | 4 | 4 | 5.3 | O=C(O)C[C@H](Cc1ccccc1)NC(=O)/C(=C/c1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1016/S0960-894X(00)80273-5 | |||
| 44333048 | 169360 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 1032 | 28 | 10 | 11 | 3.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 | 10.1021/jm00072a024 | |||
| CHEMBL441165 | 169360 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 1032 | 28 | 10 | 11 | 3.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 | 10.1021/jm00072a024 | |||
| 73349806 | 96495 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 1019 | 29 | 9 | 11 | 4.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| CHEMBL262155 | 96495 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 1019 | 29 | 9 | 11 | 4.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| 44348764 | 168735 | None | 0 | Bovine | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 980 | 28 | 11 | 11 | 1.4 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
| CHEMBL436199 | 168735 | None | 0 | Bovine | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 980 | 28 | 11 | 11 | 1.4 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||
| 10052234 | 67783 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 515 | 5 | 2 | 4 | 4.3 | O=C(Nc1ccc(Cl)cc1)N[C@H]1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1021/jm00078a018 | |||
| CHEMBL1907927 | 67783 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 515 | 5 | 2 | 4 | 4.3 | O=C(Nc1ccc(Cl)cc1)N[C@H]1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O | 10.1021/jm00078a018 | |||
| 44368541 | 168719 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 590 | 13 | 5 | 5 | 4.5 | C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL436065 | 168719 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 590 | 13 | 5 | 5 | 4.5 | C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| 73349872 | 89235 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 616 | 12 | 5 | 5 | 5.2 | CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 | 10.1016/S0960-894X(97)00107-8 | |||
| CHEMBL2367718 | 89235 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 616 | 12 | 5 | 5 | 5.2 | CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 | 10.1016/S0960-894X(97)00107-8 | |||
| CHEMBL2367719 | 89235 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 616 | 12 | 5 | 5 | 5.2 | CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 | 10.1016/S0960-894X(97)00107-8 | |||
| 10370499 | 36963 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
| CHEMBL145133 | 36963 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
| 10370499 | 36963 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 | 10.1016/s0960-894x(98)00677-5 | |||
| CHEMBL145133 | 36963 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 | 10.1016/s0960-894x(98)00677-5 | |||
| 10370499 | 86024 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL2304064 | 86024 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| 155517868 | 170314 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 1893 | 76 | 19 | 24 | 3.2 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4445353 | 170314 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 1893 | 76 | 19 | 24 | 3.2 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 9887120 | 206584 | None | 4 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00121a004 | |||
| CHEMBL70380 | 206584 | None | 4 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00121a004 | |||
| 10324540 | 16597 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 524 | 5 | 3 | 3 | 5.8 | CC(C)(C)NC(=O)CN1C(=O)[C@@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](C2CCCCC2)c2ccccc21 | 10.1021/jm00048a015 | |||
| CHEMBL123981 | 16597 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 524 | 5 | 3 | 3 | 5.8 | CC(C)(C)NC(=O)CN1C(=O)[C@@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](C2CCCCC2)c2ccccc21 | 10.1021/jm00048a015 | |||
| 14843054 | 120028 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 503 | 6 | 1 | 5 | 5.4 | COc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1OC | 10.1021/jm00108a040 | |||
| CHEMBL34979 | 120028 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 503 | 6 | 1 | 5 | 5.4 | COc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1OC | 10.1021/jm00108a040 | |||
| 44356972 | 27664 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 555 | 7 | 3 | 7 | 3.3 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)ON3CCC[C@@H]3C(=O)O)C2=O)c1 | 10.1021/jm00078a018 | |||
| CHEMBL136990 | 27664 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 555 | 7 | 3 | 7 | 3.3 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)ON3CCC[C@@H]3C(=O)O)C2=O)c1 | 10.1021/jm00078a018 | |||
| 15689734 | 106665 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 854 | 21 | 9 | 9 | 3.5 | CC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 | 10.1021/jm00113a023 | |||
| CHEMBL3142899 | 106665 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 854 | 21 | 9 | 9 | 3.5 | CC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 | 10.1021/jm00113a023 | |||
| 15167816 | 206954 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 493 | 6 | 1 | 5 | 4.0 | CCOC(=O)CN1C(=O)C(NC(=O)c2ccccc2Cl)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| CHEMBL72546 | 206954 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 493 | 6 | 1 | 5 | 4.0 | CCOC(=O)CN1C(=O)C(NC(=O)c2ccccc2Cl)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| 44382561 | 168409 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 662 | 13 | 5 | 5 | 5.8 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCc1ccc(O)cc1 | 10.1016/S0960-894X(00)80687-3 | |||
| CHEMBL434113 | 168409 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 662 | 13 | 5 | 5 | 5.8 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCc1ccc(O)cc1 | 10.1016/S0960-894X(00)80687-3 | |||
| 14843038 | 138295 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 473 | 5 | 1 | 4 | 5.4 | COc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 | 10.1021/jm00108a040 | |||
| CHEMBL37699 | 138295 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 473 | 5 | 1 | 4 | 5.4 | COc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 | 10.1021/jm00108a040 | |||
| CHEMBL338056 | 214063 | None | 0 | Bovine | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00099a005 | |||||
| 44280374 | 102922 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 559 | 8 | 3 | 4 | 5.4 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1cccc(C(=O)O)c1 | 10.1021/jm950372w | |||
| CHEMBL30575 | 102922 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 559 | 8 | 3 | 4 | 5.4 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1cccc(C(=O)O)c1 | 10.1021/jm950372w | |||
| 44210428 | 59131 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 485 | 4 | 2 | 4 | 3.1 | CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3cccc4ccccc34)CCc3ccccc32)CC1 | 10.1016/S0960-894X(00)80683-6 | |||
| CHEMBL169794 | 59131 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 485 | 4 | 2 | 4 | 3.1 | CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3cccc4ccccc34)CCc3ccccc32)CC1 | 10.1016/S0960-894X(00)80683-6 | |||
| 14208288 | 67704 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 349 | 2 | 1 | 3 | 3.0 | CN1C(=O)[C@@H](NC(=O)C(C)(C)C)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
| CHEMBL1907660 | 67704 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 349 | 2 | 1 | 3 | 3.0 | CN1C(=O)[C@@H](NC(=O)C(C)(C)C)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
| 44382560 | 120381 | None | 0 | Mouse | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 660 | 14 | 4 | 4 | 6.5 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCCc1ccccc1 | 10.1016/S0960-894X(00)80687-3 | |||
| CHEMBL352817 | 120381 | None | 0 | Mouse | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 660 | 14 | 4 | 4 | 6.5 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCCc1ccccc1 | 10.1016/S0960-894X(00)80687-3 | |||
| 44370473 | 50877 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 435 | 15 | 3 | 4 | 4.3 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)Nc1cccc(OC)c1 | 10.1021/jm00164a020 | |||
| CHEMBL157722 | 50877 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 435 | 15 | 3 | 4 | 4.3 | CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)Nc1cccc(OC)c1 | 10.1021/jm00164a020 | |||
| 44283496 | 100228 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 527 | 9 | 2 | 3 | 6.1 | CC(=O)N(CCc1ccccc1)CC(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
| CHEMBL288037 | 100228 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 527 | 9 | 2 | 3 | 6.1 | CC(=O)N(CCc1ccccc1)CC(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
| 44408525 | 169531 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | -56 | 3 | ChEMBL | 1075 | 30 | 12 | 14 | 1.5 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](Cc1cn(C(C)=O)c2ccccc12)C(=O)O | 10.1021/jm050851n | |||
| CHEMBL442483 | 169531 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | -56 | 3 | ChEMBL | 1075 | 30 | 12 | 14 | 1.5 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](Cc1cn(C(C)=O)c2ccccc12)C(=O)O | 10.1021/jm050851n | |||
| 10624013 | 33546 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 464 | 6 | 3 | 4 | 4.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CCCC1 | 10.1021/jm970065l | |||
| CHEMBL142063 | 33546 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 464 | 6 | 3 | 4 | 4.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CCCC1 | 10.1021/jm970065l | |||
| 10886229 | 78624 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 559 | 6 | 3 | 5 | 4.4 | Cc1cccc(N2C(=O)C[C@@H]3[C@@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)c1 | 10.1021/jm010813d | |||
| CHEMBL2112234 | 78624 | None | 0 | Rat | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 559 | 6 | 3 | 5 | 4.4 | Cc1cccc(N2C(=O)C[C@@H]3[C@@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)c1 | 10.1021/jm010813d | |||
| 44329150 | 112464 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 580 | 7 | 3 | 3 | 6.8 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC3(C)CCCCC3)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
| CHEMBL329735 | 112464 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 580 | 7 | 3 | 3 | 6.8 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC3(C)CCCCC3)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
| 16100409 | 83266 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 3 | ChEMBL | 1031 | 27 | 13 | 12 | 0.2 | CCCC[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
| CHEMBL218651 | 83266 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 3 | ChEMBL | 1031 | 27 | 13 | 12 | 0.2 | CCCC[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
| 44280894 | 113574 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 708 | 19 | 3 | 5 | 6.6 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL33209 | 113574 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 708 | 19 | 3 | 5 | 6.6 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 44280213 | 101673 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 685 | 12 | 5 | 9 | 3.7 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL29888 | 101673 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 685 | 12 | 5 | 9 | 3.7 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| 44281005 | 116795 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 787 | 17 | 4 | 8 | 6.4 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 | 10.1016/S0960-894X(96)00249-1 | |||
| CHEMBL33743 | 116795 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 787 | 17 | 4 | 8 | 6.4 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 | 10.1016/S0960-894X(96)00249-1 | |||
| 44280915 | 100333 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 676 | 10 | 3 | 5 | 5.2 | O=C(O)C[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL289008 | 100333 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 676 | 10 | 3 | 5 | 5.2 | O=C(O)C[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 44280205 | 13073 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 695 | 12 | 4 | 6 | 5.6 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ncccc12 | 10.1021/jm950372w | |||
| CHEMBL1190133 | 13073 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 695 | 12 | 4 | 6 | 5.6 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ncccc12 | 10.1021/jm950372w | |||
| CHEMBL540261 | 13073 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 695 | 12 | 4 | 6 | 5.6 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ncccc12 | 10.1021/jm950372w | |||
| 44279811 | 96978 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 743 | 15 | 4 | 7 | 5.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL265987 | 96978 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 743 | 15 | 4 | 7 | 5.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
| 44403829 | 71476 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 743 | 15 | 4 | 7 | 5.3 | CN1C(=O)[C@H](NC(=O)Nc2ccc(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm058225d | |||
| CHEMBL196143 | 71476 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 743 | 15 | 4 | 7 | 5.3 | CN1C(=O)[C@H](NC(=O)Nc2ccc(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm058225d | |||
| 10453063 | 107047 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 391 | 2 | 2 | 4 | 3.0 | Cc1cccc(NC(=O)NC2N=C(N3CCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
| CHEMBL315214 | 107047 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 391 | 2 | 2 | 4 | 3.0 | Cc1cccc(NC(=O)NC2N=C(N3CCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
| 10673193 | 98197 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 506 | 6 | 2 | 5 | 5.3 | CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 | 10.1016/S0960-894X(97)00108-X | |||
| CHEMBL273693 | 98197 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 506 | 6 | 2 | 5 | 5.3 | CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 | 10.1016/S0960-894X(97)00108-X | |||
| 10453063 | 107047 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 391 | 2 | 2 | 4 | 3.0 | Cc1cccc(NC(=O)NC2N=C(N3CCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm9608523 | |||
| CHEMBL315214 | 107047 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 391 | 2 | 2 | 4 | 3.0 | Cc1cccc(NC(=O)NC2N=C(N3CCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm9608523 | |||
| 10671800 | 209201 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 463 | 6 | 3 | 6 | 5.0 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(Cl)cc3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
| CHEMBL8997 | 209201 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 463 | 6 | 3 | 6 | 5.0 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(Cl)cc3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
| 10094721 | 209352 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 439 | 5 | 3 | 7 | 3.5 | CN(C)c1cccc(-n2c(NNC(=O)Nc3cccc(C#N)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
| CHEMBL9083 | 209352 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 439 | 5 | 3 | 7 | 3.5 | CN(C)c1cccc(-n2c(NNC(=O)Nc3cccc(C#N)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
| 10649303 | 209915 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 507 | 6 | 3 | 6 | 5.1 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
| CHEMBL9422 | 209915 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 507 | 6 | 3 | 6 | 5.1 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
| 10838356 | 210103 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 477 | 6 | 3 | 7 | 4.4 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)c1 | 10.1021/jm970373j | |||
| CHEMBL9524 | 210103 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 477 | 6 | 3 | 7 | 4.4 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)c1 | 10.1021/jm970373j | |||
| 73349789 | 106193 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 629 | 12 | 6 | 6 | 4.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)NO)c1ccccc1 | 10.1021/jm00092a007 | |||
| CHEMBL313499 | 106193 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 629 | 12 | 6 | 6 | 4.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)NO)c1ccccc1 | 10.1021/jm00092a007 | |||
| 14802536 | 157423 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 628 | 13 | 5 | 5 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCCC(=O)O)c1ccccc1 | 10.1021/jm00105a062 | |||
| CHEMBL2112694 | 157423 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 628 | 13 | 5 | 5 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCCC(=O)O)c1ccccc1 | 10.1021/jm00105a062 | |||
| CHEMBL407753 | 157423 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 628 | 13 | 5 | 5 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCCC(=O)O)c1ccccc1 | 10.1021/jm00105a062 | |||
| 73354298 | 96724 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 1017 | 29 | 9 | 10 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| CHEMBL263876 | 96724 | None | 0 | Rat | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 1017 | 29 | 9 | 10 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| 44280214 | 107358 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 770 | 16 | 6 | 10 | 3.6 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL31726 | 107358 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 770 | 16 | 6 | 10 | 3.6 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| 15673181 | 86030 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 629 | 12 | 6 | 6 | 4.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)NO)c1ccccc1 | 10.1016/S0960-894X(00)80652-6 | |||
| CHEMBL2304156 | 86030 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 629 | 12 | 6 | 6 | 4.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)NO)c1ccccc1 | 10.1016/S0960-894X(00)80652-6 | |||
| 9827037 | 78860 | None | 9 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 493 | 6 | 4 | 4 | 4.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H]1CCCC[C@@H]1O | 10.1021/jm970065l | |||
| CHEMBL2112795 | 78860 | None | 9 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 493 | 6 | 4 | 4 | 4.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H]1CCCC[C@@H]1O | 10.1021/jm970065l | |||
| 9978327 | 78847 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 400 | 3 | 3 | 4 | 3.4 | CN1C(=O)[C@H](NC(=O)Nc2cccc(O)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| CHEMBL2112753 | 78847 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 400 | 3 | 3 | 4 | 3.4 | CN1C(=O)[C@H](NC(=O)Nc2cccc(O)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| 44381641 | 168744 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 723 | 20 | 7 | 8 | 3.2 | CCCC[C@H](N[C@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(97)00107-8 | |||
| CHEMBL436253 | 168744 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 723 | 20 | 7 | 8 | 3.2 | CCCC[C@H](N[C@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(97)00107-8 | |||
| 10673193 | 98197 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 506 | 6 | 2 | 5 | 5.3 | CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
| CHEMBL273693 | 98197 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 506 | 6 | 2 | 5 | 5.3 | CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
| 44373702 | 119990 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 555 | 8 | 4 | 4 | 5.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@]1(C(=O)O)C[C@H]1c1ccccc1 | 10.1016/S0960-894X(01)81250-6 | |||
| CHEMBL349473 | 119990 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 555 | 8 | 4 | 4 | 5.1 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@]1(C(=O)O)C[C@H]1c1ccccc1 | 10.1016/S0960-894X(01)81250-6 | |||
| CHEMBL2310857 | 211948 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N1CC(OS(=O)(=O)O)C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||||
| 44368382 | 45353 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 511 | 9 | 4 | 4 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL152682 | 45353 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 511 | 9 | 4 | 4 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| 44280111 | 100023 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 684 | 11 | 3 | 5 | 5.0 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCc2ccccc2C1 | 10.1021/jm950372w | |||
| CHEMBL286510 | 100023 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 684 | 11 | 3 | 5 | 5.0 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCc2ccccc2C1 | 10.1021/jm950372w | |||
| 15689729 | 106653 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 890 | 20 | 9 | 8 | 4.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1Br)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
| CHEMBL3142695 | 106653 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 890 | 20 | 9 | 8 | 4.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1Br)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
| CHEMBL320868 | 213688 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 2 | ChEMBL | None | None | None | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||||
| 15689733 | 106670 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 870 | 21 | 9 | 10 | 3.0 | COC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 | 10.1021/jm00113a023 | |||
| CHEMBL3142905 | 106670 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 870 | 21 | 9 | 10 | 3.0 | COC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 | 10.1021/jm00113a023 | |||
| CHEMBL3142923 | 213596 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | None | None | None | COc1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 | 10.1021/jm960509y | |||||
| CHEMBL320868 | 213688 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 2 | ChEMBL | None | None | None | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm960509y | |||||
| 44381695 | 120902 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 811 | 20 | 8 | 8 | 4.3 | Cc1ccccc1NC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1016/S0960-894X(00)80680-0 | |||
| CHEMBL355836 | 120902 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 811 | 20 | 8 | 8 | 4.3 | Cc1ccccc1NC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1016/S0960-894X(00)80680-0 | |||
| 65987 | 99631 | None | 12 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 440 | 6 | 2 | 3 | 4.1 | O=C(O)CC[C@@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
| CHEMBL283820 | 99631 | None | 12 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 440 | 6 | 2 | 3 | 4.1 | O=C(O)CC[C@@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
| 136026477 | 208506 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 499 | 5 | 1 | 4 | 6.6 | CC(C)Oc1cccc(-n2c(/C=C/c3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 | 10.1021/jm00092a003 | |||
| CHEMBL85250 | 208506 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 499 | 5 | 1 | 4 | 6.6 | CC(C)Oc1cccc(-n2c(/C=C/c3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 | 10.1021/jm00092a003 | |||
| 14208194 | 163531 | None | 2 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 2 | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
| CHEMBL419764 | 163531 | None | 2 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 2 | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
| CHEMBL320868 | 213688 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 2 | ChEMBL | None | None | None | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00031a013 | |||||
| 73345199 | 141832 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 1019 | 29 | 9 | 11 | 4.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| CHEMBL385918 | 141832 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 1019 | 29 | 9 | 11 | 4.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| 65987 | 99631 | None | 12 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 440 | 6 | 2 | 3 | 4.1 | O=C(O)CC[C@@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL283820 | 99631 | None | 12 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 440 | 6 | 2 | 3 | 4.1 | O=C(O)CC[C@@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 14991571 | 205394 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 905 | 21 | 8 | 10 | 3.9 | CC(=O)Oc1ccc2cc(C(=O)NCCCC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)ccc2c1 | 10.1021/jm00089a010 | |||
| CHEMBL62887 | 205394 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 905 | 21 | 8 | 10 | 3.9 | CC(=O)Oc1ccc2cc(C(=O)NCCCC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)ccc2c1 | 10.1021/jm00089a010 | |||
| 14208214 | 165343 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 405 | 3 | 2 | 3 | 4.4 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc2ccccc2c1 | 10.1021/jm00120a002 | |||
| CHEMBL422951 | 165343 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 405 | 3 | 2 | 3 | 4.4 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc2ccccc2c1 | 10.1021/jm00120a002 | |||
| 14208204 | 206923 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 407 | 3 | 2 | 3 | 4.0 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc(Cl)cc1 | 10.1021/jm00120a002 | |||
| CHEMBL72300 | 206923 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 407 | 3 | 2 | 3 | 4.0 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc(Cl)cc1 | 10.1021/jm00120a002 | |||
| 44209151 | 59452 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 301 | 3 | 2 | 2 | 3.8 | O=C(Cc1ccccc1)Nc1cc2c3ccccc3nc-2c[nH]1 | 10.1016/S0960-894X(00)80682-4 | |||
| CHEMBL171108 | 59452 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 301 | 3 | 2 | 2 | 3.8 | O=C(Cc1ccccc1)Nc1cc2c3ccccc3nc-2c[nH]1 | 10.1016/S0960-894X(00)80682-4 | |||
| 44303299 | 203708 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 598 | 11 | 4 | 6 | 5.5 | CC(Cc1ccc(Oc2ccccc2)cc1)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
| CHEMBL60386 | 203708 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 598 | 11 | 4 | 6 | 5.5 | CC(Cc1ccc(Oc2ccccc2)cc1)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
| 44279937 | 104918 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 690 | 11 | 3 | 5 | 5.6 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL31101 | 104918 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 690 | 11 | 3 | 5 | 5.6 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 44329330 | 107243 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 540 | 6 | 3 | 3 | 5.9 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3cccc(C)c3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
| CHEMBL316504 | 107243 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 540 | 6 | 3 | 3 | 5.9 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3cccc(C)c3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
| 52949124 | 876 | None | 4 | Human | Binding | pIC50 | = | 6.9 | 6.9 | 2 | 2 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| 9055 | 876 | None | 4 | Human | Binding | pIC50 | = | 6.9 | 6.9 | 2 | 2 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| CHEMBL1269258 | 876 | None | 4 | Human | Binding | pIC50 | = | 6.9 | 6.9 | 2 | 2 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| DB12694 | 876 | None | 4 | Human | Binding | pIC50 | = | 6.9 | 6.9 | 2 | 2 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| 44280368 | 96950 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 573 | 8 | 2 | 4 | 5.4 | CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccc(C(=O)O)cc1 | 10.1021/jm950372w | |||
| CHEMBL265740 | 96950 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 573 | 8 | 2 | 4 | 5.4 | CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccc(C(=O)O)cc1 | 10.1021/jm950372w | |||
| 11742839 | 12828 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 419 | 2 | 2 | 4 | 3.7 | Cc1cccc(NC(=O)N[C@H]2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
| CHEMBL1188361 | 12828 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 419 | 2 | 2 | 4 | 3.7 | Cc1cccc(NC(=O)N[C@H]2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
| CHEMBL536245 | 12828 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 419 | 2 | 2 | 4 | 3.7 | Cc1cccc(NC(=O)N[C@H]2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
| 44280397 | 103731 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 587 | 10 | 3 | 4 | 4.9 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccccc1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL30875 | 103731 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 587 | 10 | 3 | 4 | 4.9 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccccc1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL262172 | 212987 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | -691 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | |||||
| 14888709 | 77279 | None | 0 | Bovine | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 1031 | 30 | 11 | 12 | 0.3 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(CC(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
| CHEMBL2079603 | 77279 | None | 0 | Bovine | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 1031 | 30 | 11 | 12 | 0.3 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(CC(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
| 44280103 | 168061 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 573 | 8 | 2 | 4 | 5.4 | CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccccc1C(=O)O | 10.1021/jm950372w | |||
| CHEMBL431692 | 168061 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 573 | 8 | 2 | 4 | 5.4 | CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccccc1C(=O)O | 10.1021/jm950372w | |||
| 44331954 | 4453 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 508 | 12 | 2 | 3 | 4.8 | CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCC1CCCCC1)CC(=O)N1CCCC1 | 10.1016/S0960-894X(96)00546-X | |||
| CHEMBL101681 | 4453 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 508 | 12 | 2 | 3 | 4.8 | CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCC1CCCCC1)CC(=O)N1CCCC1 | 10.1016/S0960-894X(96)00546-X | |||
| 44368567 | 168838 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 495 | 9 | 4 | 4 | 4.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1F)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL437039 | 168838 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 495 | 9 | 4 | 4 | 4.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1F)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| 10574611 | 209709 | None | 0 | Mouse | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 429 | 6 | 3 | 6 | 4.3 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccccc3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
| CHEMBL9291 | 209709 | None | 0 | Mouse | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 429 | 6 | 3 | 6 | 4.3 | CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccccc3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
| 10838217 | 209793 | None | 0 | Mouse | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 473 | 7 | 3 | 8 | 3.7 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)c1 | 10.1021/jm970373j | |||
| CHEMBL9354 | 209793 | None | 0 | Mouse | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 473 | 7 | 3 | 8 | 3.7 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)c1 | 10.1021/jm970373j | |||
| 44330731 | 210703 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 946 | 25 | 9 | 11 | 0.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CC[C@H](NC(=O)CCc2ccc(OS(=O)(=O)O)cc2)C1=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
| CHEMBL98720 | 210703 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 946 | 25 | 9 | 11 | 0.6 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CC[C@H](NC(=O)CCc2ccc(OS(=O)(=O)O)cc2)C1=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
| 73351326 | 82415 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 1017 | 29 | 9 | 10 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| CHEMBL217234 | 82415 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 1017 | 29 | 9 | 10 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| 44368382 | 45353 | None | 0 | Mouse | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 511 | 9 | 4 | 4 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL152682 | 45353 | None | 0 | Mouse | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 511 | 9 | 4 | 4 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| 10672231 | 208415 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 475 | 5 | 3 | 4 | 4.9 | CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCC(C)(C)CCN2)c2ccccc21 | 10.1021/jm9608523 | |||
| CHEMBL84433 | 208415 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 475 | 5 | 3 | 4 | 4.9 | CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCC(C)(C)CCN2)c2ccccc21 | 10.1021/jm9608523 | |||
| CHEMBL208479 | 211658 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | -5 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | |||||
| CHEMBL218763 | 211858 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | -15 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
| 155534993 | 172098 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 1385 | 38 | 16 | 19 | -3.1 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.9b01936 | |||
| CHEMBL4471171 | 172098 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 1385 | 38 | 16 | 19 | -3.1 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.9b01936 | |||
| 71719689 | 86023 | None | 0 | Mouse | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 500 | 8 | 3 | 4 | 4.8 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccn1 | 10.1016/S0960-894X(01)80769-1 | |||
| CHEMBL2304063 | 86023 | None | 0 | Mouse | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 500 | 8 | 3 | 4 | 4.8 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccn1 | 10.1016/S0960-894X(01)80769-1 | |||
| 155548021 | 173768 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 1409 | 38 | 15 | 21 | -2.2 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)n1cc(CNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.9b01936 | |||
| CHEMBL4534788 | 173768 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 1409 | 38 | 15 | 21 | -2.2 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)n1cc(CNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.9b01936 | |||
| 10454826 | 99393 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 420 | 3 | 2 | 3 | 4.5 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](N3CCCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/0960-894X(95)00234-K | |||
| CHEMBL282294 | 99393 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 420 | 3 | 2 | 3 | 4.5 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](N3CCCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/0960-894X(95)00234-K | |||
| 10415786 | 169821 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 577 | 7 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(O)cc1 | 10.1021/jm950626d | |||
| CHEMBL443825 | 169821 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 577 | 7 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(O)cc1 | 10.1021/jm950626d | |||
| 44210427 | 120832 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 459 | 4 | 2 | 4 | 4.7 | CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)CCc2ccccc21 | 10.1016/S0960-894X(00)80683-6 | |||
| CHEMBL355319 | 120832 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 459 | 4 | 2 | 4 | 4.7 | CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)CCc2ccccc21 | 10.1016/S0960-894X(00)80683-6 | |||
| 11803746 | 106669 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 870 | 21 | 9 | 10 | 3.0 | COC(=O)c1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm960509y | |||
| CHEMBL3142904 | 106669 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 870 | 21 | 9 | 10 | 3.0 | COC(=O)c1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm960509y | |||
| 9887120 | 206584 | None | 4 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm000937a | |||
| CHEMBL70380 | 206584 | None | 4 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm000937a | |||
| 14843030 | 100340 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 379 | 4 | 1 | 3 | 5.0 | Cc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 | 10.1021/jm00108a040 | |||
| CHEMBL289053 | 100340 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 379 | 4 | 1 | 3 | 5.0 | Cc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 | 10.1021/jm00108a040 | |||
| 9887120 | 206584 | None | 4 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(00)80684-8 | |||
| CHEMBL70380 | 206584 | None | 4 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(00)80684-8 | |||
| CHEMBL320868 | 213688 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 2 | ChEMBL | None | None | None | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00173a006 | |||||
| 14208284 | 67757 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 375 | 3 | 1 | 3 | 3.5 | CN1C(=O)[C@H](NC(=O)C2CCCCC2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
| CHEMBL1907838 | 67757 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 375 | 3 | 1 | 3 | 3.5 | CN1C(=O)[C@H](NC(=O)C2CCCCC2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
| 14444021 | 106731 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 692 | 17 | 7 | 7 | 2.7 | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00123a003 | |||
| CHEMBL3143386 | 106731 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 692 | 17 | 7 | 7 | 2.7 | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00123a003 | |||
| 73346732 | 170024 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 1017 | 29 | 9 | 10 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| CHEMBL444113 | 170024 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 1017 | 29 | 9 | 10 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| 44283159 | 100188 | None | 0 | Mouse | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 515 | 8 | 3 | 3 | 6.6 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)/C(S)=N/CCc1ccccc1 | 10.1021/jm00086a017 | |||
| CHEMBL287682 | 100188 | None | 0 | Mouse | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 515 | 8 | 3 | 3 | 6.6 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)/C(S)=N/CCc1ccccc1 | 10.1021/jm00086a017 | |||
| 44362746 | 119055 | None | 0 | Mouse | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 680 | 12 | 3 | 6 | 5.7 | C[Si](C)(C)CCOC(=O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1016/s0960-894x(98)00677-5 | |||
| CHEMBL342520 | 119055 | None | 0 | Mouse | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 680 | 12 | 3 | 6 | 5.7 | C[Si](C)(C)CCOC(=O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1016/s0960-894x(98)00677-5 | |||
| 90663994 | 106879 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 837 | 21 | 8 | 8 | 3.6 | Cc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm00089a010 | |||
| CHEMBL3144563 | 106879 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 837 | 21 | 8 | 8 | 3.6 | Cc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm00089a010 | |||
| 44334224 | 5057 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 480 | 7 | 2 | 5 | 3.3 | Cc1cccc(NC(=O)N[C@H](COC(=O)N(C)C)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
| CHEMBL105303 | 5057 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 480 | 7 | 2 | 5 | 3.3 | Cc1cccc(NC(=O)N[C@H](COC(=O)N(C)C)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
| CHEMBL3142685 | 213587 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | None | None | None | Cc1ccccc1NC(=O)NCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||||
| 44366345 | 119549 | None | 0 | Mouse | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 447 | 6 | 2 | 2 | 5.8 | O=C1[C@@H](Cc2c[nH]c3ccccc23)CN(Cc2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/0960-894X(94)80030-8 | |||
| CHEMBL345327 | 119549 | None | 0 | Mouse | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 447 | 6 | 2 | 2 | 5.8 | O=C1[C@@H](Cc2c[nH]c3ccccc23)CN(Cc2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 | 10.1016/0960-894X(94)80030-8 | |||
| CHEMBL355608 | 214198 | None | 0 | Mouse | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N1CC(=O)N[C@H](Cc2ccccc2)C1 | 10.1016/S0960-894X(01)80253-5 | |||||
| CHEMBL436451 | 216142 | None | 0 | Mouse | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O | 10.1016/S0960-894X(01)80253-5 | |||||
| 44366108 | 43970 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 635 | 15 | 6 | 6 | 3.8 | CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NCc1ccccc1 | 10.1021/jm00123a003 | |||
| CHEMBL151276 | 43970 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 635 | 15 | 6 | 6 | 3.8 | CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NCc1ccccc1 | 10.1021/jm00123a003 | |||
| 44377588 | 120209 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 636 | 15 | 7 | 6 | 3.7 | CCCC[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)NCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm00388a002 | |||
| CHEMBL351313 | 120209 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 636 | 15 | 7 | 6 | 3.7 | CCCC[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)NCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm00388a002 | |||
| 14208231 | 206704 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 422 | 3 | 1 | 4 | 3.7 | CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
| CHEMBL71079 | 206704 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 422 | 3 | 1 | 4 | 3.7 | CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
| 9887120 | 206584 | None | 4 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00121a004 | |||
| CHEMBL70380 | 206584 | None | 4 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00121a004 | |||
| 9887120 | 206584 | None | 4 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm970517u | |||
| CHEMBL70380 | 206584 | None | 4 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm970517u | |||
| 10551230 | 209768 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 443 | 6 | 3 | 7 | 3.7 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccccc2)c1 | 10.1021/jm970373j | |||
| CHEMBL9336 | 209768 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 443 | 6 | 3 | 7 | 3.7 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccccc2)c1 | 10.1021/jm970373j | |||
| 44303237 | 100861 | None | 0 | Mouse | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 590 | 10 | 4 | 8 | 4.3 | CC(Cc1ccc(-c2csnn2)cc1)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
| CHEMBL293178 | 100861 | None | 0 | Mouse | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 590 | 10 | 4 | 8 | 4.3 | CC(Cc1ccc(-c2csnn2)cc1)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
| 44408526 | 137032 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | -1862 | 4 | ChEMBL | 1148 | 30 | 11 | 15 | 3.0 | CCCC[C@@H](C(=O)N[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O)N(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O | 10.1021/jm050851n | |||
| CHEMBL374325 | 137032 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | -1862 | 4 | ChEMBL | 1148 | 30 | 11 | 15 | 3.0 | CCCC[C@@H](C(=O)N[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O)N(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O | 10.1021/jm050851n | |||
| 44280509 | 99458 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 588 | 10 | 3 | 5 | 4.3 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccccn1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL282732 | 99458 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 588 | 10 | 3 | 5 | 4.3 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccccn1)C(=O)O | 10.1021/jm950372w | |||
| 44280117 | 102106 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 672 | 12 | 3 | 6 | 5.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL30195 | 102106 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 672 | 12 | 3 | 6 | 5.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| 9802550 | 119240 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 426 | 4 | 2 | 3 | 4.4 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00163a069 | |||
| CHEMBL343066 | 119240 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 426 | 4 | 2 | 3 | 4.4 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00163a069 | |||
| 44303652 | 203146 | None | 0 | Mouse | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 570 | 8 | 2 | 3 | 7.2 | CC(Cc1ccc2c(c1)C(C)(C)CCC2(C)C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
| CHEMBL59985 | 203146 | None | 0 | Mouse | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 570 | 8 | 2 | 3 | 7.2 | CC(Cc1ccc2c(c1)C(C)(C)CCC2(C)C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
| 44280363 | 102395 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 511 | 8 | 2 | 4 | 3.6 | CN(CC(=O)O)C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL30369 | 102395 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 511 | 8 | 2 | 4 | 3.6 | CN(CC(=O)O)C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 44280176 | 99364 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 615 | 12 | 3 | 4 | 5.6 | O=C(O)CCC(Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL282099 | 99364 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 615 | 12 | 3 | 4 | 5.6 | O=C(O)CCC(Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 44280350 | 99906 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 658 | 12 | 3 | 5 | 4.7 | CN(Cc1ccccc1)C(=O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL285739 | 99906 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 658 | 12 | 3 | 5 | 4.7 | CN(Cc1ccccc1)C(=O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O | 10.1021/jm950372w | |||
| 10746778 | 47574 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 646 | 8 | 2 | 6 | 5.2 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(N2CCOCC2)cc1 | 10.1021/jm950626d | |||
| CHEMBL154615 | 47574 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 646 | 8 | 2 | 6 | 5.2 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(N2CCOCC2)cc1 | 10.1021/jm950626d | |||
| 44365304 | 164847 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 444 | 8 | 2 | 3 | 4.3 | CC(C)N(C(=O)CN(C(=O)CNC(=O)Nc1ccccc1)c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(97)00062-0 | |||
| CHEMBL421778 | 164847 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 444 | 8 | 2 | 3 | 4.3 | CC(C)N(C(=O)CN(C(=O)CNC(=O)Nc1ccccc1)c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(97)00062-0 | |||
| 44265901 | 209981 | None | 0 | Mouse | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 486 | 5 | 1 | 4 | 5.5 | CN(C)c1cccc(-n2c(CCc3c[nH]c4cc(Br)ccc34)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
| CHEMBL9459 | 209981 | None | 0 | Mouse | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 486 | 5 | 1 | 4 | 5.5 | CN(C)c1cccc(-n2c(CCc3c[nH]c4cc(Br)ccc34)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
| 71580808 | 90459 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 842 | 26 | 8 | 8 | 1.6 | C#CCCC(=O)NCCCC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2013.02.022 | |||
| CHEMBL2386888 | 90459 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 842 | 26 | 8 | 8 | 1.6 | C#CCCC(=O)NCCCC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2013.02.022 | |||
| 73349792 | 157506 | None | 0 | Mouse | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 669 | 13 | 5 | 7 | 5.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCSc1nc[nH]n1)c1ccccc1 | 10.1021/jm00092a007 | |||
| CHEMBL407857 | 157506 | None | 0 | Mouse | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 669 | 13 | 5 | 7 | 5.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCSc1nc[nH]n1)c1ccccc1 | 10.1021/jm00092a007 | |||
| 44331065 | 107282 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 974 | 25 | 8 | 11 | 1.3 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
| CHEMBL316709 | 107282 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 974 | 25 | 8 | 11 | 1.3 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
| 44300551 | 199851 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 390 | 3 | 2 | 3 | 4.1 | Cc1cccc(NC(=O)NC2N=C(C3CCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(01)80987-2 | |||
| CHEMBL56944 | 199851 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 390 | 3 | 2 | 3 | 4.1 | Cc1cccc(NC(=O)NC2N=C(C3CCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(01)80987-2 | |||
| 73351327 | 82457 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 1019 | 29 | 9 | 11 | 4.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| CHEMBL217424 | 82457 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 1019 | 29 | 9 | 11 | 4.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| 14843045 | 133620 | None | 0 | Mouse | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 486 | 5 | 1 | 4 | 5.5 | CN(C)c1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 | 10.1021/jm00108a040 | |||
| CHEMBL37096 | 133620 | None | 0 | Mouse | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 486 | 5 | 1 | 4 | 5.5 | CN(C)c1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 | 10.1021/jm00108a040 | |||
| 10480792 | 45814 | None | 0 | Mouse | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL153095 | 45814 | None | 0 | Mouse | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL3350686 | 45814 | None | 0 | Mouse | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 491 | 9 | 4 | 4 | 4.5 | CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| 44329456 | 111508 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 526 | 6 | 3 | 3 | 5.5 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
| CHEMBL327526 | 111508 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 526 | 6 | 3 | 3 | 5.5 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
| 44280200 | 100878 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 785 | 18 | 4 | 7 | 6.6 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL29331 | 100878 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 785 | 18 | 4 | 7 | 6.6 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| 19766167 | 59253 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 420 | 4 | 2 | 3 | 3.1 | Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
| CHEMBL170293 | 59253 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 420 | 4 | 2 | 3 | 3.1 | Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
| 71458029 | 78821 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 628 | 13 | 5 | 5 | 5.2 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1021/jm00105a062 | |||
| CHEMBL2112692 | 78821 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 628 | 13 | 5 | 5 | 5.2 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC[C@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1021/jm00105a062 | |||
| 4355450 | 136007 | None | 37 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 501 | 6 | 1 | 4 | 6.2 | CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 | 10.1021/jm00108a040 | |||
| CHEMBL37312 | 136007 | None | 37 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 501 | 6 | 1 | 4 | 6.2 | CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 | 10.1021/jm00108a040 | |||
| 14843032 | 138988 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 395 | 5 | 1 | 4 | 4.7 | COc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 | 10.1021/jm00108a040 | |||
| CHEMBL37829 | 138988 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 395 | 5 | 1 | 4 | 4.7 | COc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 | 10.1021/jm00108a040 | |||
| 14802537 | 59100 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
| CHEMBL169615 | 59100 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 614 | 12 | 5 | 5 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
| 44280116 | 99686 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 672 | 12 | 3 | 6 | 5.8 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL284183 | 99686 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 672 | 12 | 3 | 6 | 5.8 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
| 44280741 | 156653 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 759 | 15 | 4 | 8 | 5.8 | CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
| CHEMBL406844 | 156653 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 759 | 15 | 4 | 8 | 5.8 | CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
| 44334305 | 109775 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 514 | 9 | 3 | 4 | 4.6 | Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
| CHEMBL322913 | 109775 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 514 | 9 | 3 | 4 | 4.6 | Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
| 15689723 | 106651 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 880 | 20 | 9 | 8 | 4.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C(F)(F)F)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
| CHEMBL3142693 | 106651 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 880 | 20 | 9 | 8 | 4.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C(F)(F)F)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
| 14208227 | 102319 | None | 1 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 440 | 3 | 1 | 4 | 3.9 | CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| CHEMBL303227 | 102319 | None | 1 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 440 | 3 | 1 | 4 | 3.9 | CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| 14843042 | 127642 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 485 | 5 | 1 | 3 | 6.5 | CCc1cccc(-n2c(CC(C)c3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 | 10.1021/jm00108a040 | |||
| CHEMBL36634 | 127642 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 485 | 5 | 1 | 3 | 6.5 | CCc1cccc(-n2c(CC(C)c3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 | 10.1021/jm00108a040 | |||
| 44349268 | 16793 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 399 | 9 | 3 | 4 | 3.1 | CC(C)(C)CCCNC(=O)C(CCC(=O)O)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00079a003 | |||
| CHEMBL124509 | 16793 | None | 0 | Rat | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 399 | 9 | 3 | 4 | 3.1 | CC(C)(C)CCCNC(=O)C(CCC(=O)O)NC(=O)c1cnc2ccccc2c1 | 10.1021/jm00079a003 | |||
| 44381914 | 13008 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 522 | 14 | 1 | 4 | 4.7 | CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCN(C)CC1)NC(=O)c1ccc2ccccc2c1 | 10.1016/S0960-894X(00)80681-2 | |||
| CHEMBL1189721 | 13008 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 522 | 14 | 1 | 4 | 4.7 | CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCN(C)CC1)NC(=O)c1ccc2ccccc2c1 | 10.1016/S0960-894X(00)80681-2 | |||
| CHEMBL539320 | 13008 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 522 | 14 | 1 | 4 | 4.7 | CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCN(C)CC1)NC(=O)c1ccc2ccccc2c1 | 10.1016/S0960-894X(00)80681-2 | |||
| 44396746 | 127128 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 637 | 8 | 2 | 6 | 5.7 | C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 | 10.1021/jm0498755 | |||
| CHEMBL365620 | 127128 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 637 | 8 | 2 | 6 | 5.7 | C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 | 10.1021/jm0498755 | |||
| 44349354 | 118615 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 415 | 8 | 3 | 4 | 2.9 | CCc1cccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 | 10.1021/jm00079a003 | |||
| CHEMBL341505 | 118615 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 415 | 8 | 3 | 4 | 2.9 | CCc1cccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 | 10.1021/jm00079a003 | |||
| 44349335 | 117377 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 401 | 7 | 3 | 4 | 2.6 | Cc1cccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 | 10.1021/jm00079a003 | |||
| CHEMBL339707 | 117377 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 401 | 7 | 3 | 4 | 2.6 | Cc1cccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 | 10.1021/jm00079a003 | |||
| 44331978 | 4293 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 449 | 12 | 3 | 3 | 3.5 | CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCc1ccccc1)CC(=O)O | 10.1016/S0960-894X(96)00546-X | |||
| CHEMBL100762 | 4293 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 449 | 12 | 3 | 3 | 3.5 | CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCc1ccccc1)CC(=O)O | 10.1016/S0960-894X(96)00546-X | |||
| 73345199 | 141832 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 1019 | 29 | 9 | 11 | 4.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| CHEMBL385918 | 141832 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 1019 | 29 | 9 | 11 | 4.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| 44349390 | 17464 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 417 | 8 | 3 | 5 | 2.3 | COc1cccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 | 10.1021/jm00079a003 | |||
| CHEMBL125770 | 17464 | None | 0 | Rat | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 417 | 8 | 3 | 5 | 2.3 | COc1cccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 | 10.1021/jm00079a003 | |||
| 10699165 | 111516 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 625 | 7 | 1 | 4 | 6.9 | CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(C(F)(F)F)cc1 | 10.1021/jm970265x | |||
| CHEMBL327552 | 111516 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 625 | 7 | 1 | 4 | 6.9 | CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(C(F)(F)F)cc1 | 10.1021/jm970265x | |||
| 44359338 | 168769 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 489 | 6 | 3 | 3 | 5.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CC2CCC1C2 | 10.1021/jm970065l | |||
| CHEMBL436411 | 168769 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 489 | 6 | 3 | 3 | 5.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CC2CCC1C2 | 10.1021/jm970065l | |||
| 44280180 | 102688 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 655 | 11 | 5 | 8 | 3.6 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL30430 | 102688 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 655 | 11 | 5 | 8 | 3.6 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL292097 | 213344 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(01)81005-2 | |||||
| 6957640 | 159455 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 404 | 3 | 2 | 3 | 4.5 | Cc1cccc(NC(=O)N[C@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(01)80987-2 | |||
| CHEMBL410035 | 159455 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 404 | 3 | 2 | 3 | 4.5 | Cc1cccc(NC(=O)N[C@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(01)80987-2 | |||
| 16100407 | 82703 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | -112 | 3 | ChEMBL | 1132 | 28 | 13 | 13 | 1.7 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
| CHEMBL217957 | 82703 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | -112 | 3 | ChEMBL | 1132 | 28 | 13 | 13 | 1.7 | CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm061268p | |||
| 44279852 | 99416 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 690 | 11 | 3 | 5 | 5.6 | O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL282476 | 99416 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 690 | 11 | 3 | 5 | 5.6 | O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 10603713 | 111711 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 605 | 8 | 1 | 5 | 6.0 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4cccc(F)c34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
| CHEMBL328586 | 111711 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 605 | 8 | 1 | 5 | 6.0 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4cccc(F)c34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
| CHEMBL282175 | 99375 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 769 | 16 | 6 | 11 | 4.6 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CCOC(=O)NCCCC(=O)NCCSCc3csc(C=C(N)N)n3)C2=O)c1 | 10.1016/S0960-894X(96)00249-1 | |||
| 44331850 | 210711 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 600 | 13 | 3 | 4 | 4.7 | O=C(Cc1c[nH]c2ccccc12)N[C@@H](CCc1ccccc1)C(=O)N(CCC1CCCCC1)CC(=O)N1CCC[C@H]1C(=O)O | 10.1016/S0960-894X(96)00546-X | |||
| CHEMBL98788 | 210711 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 600 | 13 | 3 | 4 | 4.7 | O=C(Cc1c[nH]c2ccccc12)N[C@@H](CCc1ccccc1)C(=O)N(CCC1CCCCC1)CC(=O)N1CCC[C@H]1C(=O)O | 10.1016/S0960-894X(96)00546-X | |||
| 145988494 | 167279 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 425 | 5 | 2 | 7 | 3.6 | CCOc1ccc(-n2c(N/N=C3\C(=O)Nc4ccccc43)nc3ccccc3c2=O)cc1 | 10.1039/C7MD00171A | |||
| CHEMBL4291306 | 167279 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 425 | 5 | 2 | 7 | 3.6 | CCOc1ccc(-n2c(N/N=C3\C(=O)Nc4ccccc43)nc3ccccc3c2=O)cc1 | 10.1039/C7MD00171A | |||
| CHEMBL263155 | 213019 | None | 0 | Bovine | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)NC(C)(C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00100a033 | |||||
| 444998 | 211778 | None | 25 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00173a006 | |||||
| CHEMBL216166 | 211778 | None | 25 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00173a006 | |||||
| 443375 | 210065 | None | 33 | Human | Binding | pIC50 | = | 6.8 | 6.8 | -316 | 5 | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
| CHEMBL9506 | 210065 | None | 33 | Human | Binding | pIC50 | = | 6.8 | 6.8 | -316 | 5 | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
| 44354128 | 20301 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 628 | 13 | 5 | 5 | 4.7 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1021/jm00105a062 | |||
| CHEMBL130578 | 20301 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 628 | 13 | 5 | 5 | 4.7 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1021/jm00105a062 | |||
| 14802521 | 59101 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 628 | 13 | 5 | 5 | 4.7 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
| CHEMBL169616 | 59101 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 628 | 13 | 5 | 5 | 4.7 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
| 44356717 | 116844 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 513 | 5 | 3 | 5 | 4.7 | CN1C(=O)C(NC(=O)Nc2cccc(CNC(=O)OC(C)(C)C)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| CHEMBL337722 | 116844 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 513 | 5 | 3 | 5 | 4.7 | CN1C(=O)C(NC(=O)Nc2cccc(CNC(=O)OC(C)(C)C)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| 367893 | 51635 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 429 | 14 | 3 | 3 | 4.3 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00164a020 | |||
| CHEMBL158362 | 51635 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 429 | 14 | 3 | 3 | 4.3 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00164a020 | |||
| 443375 | 210065 | None | 33 | Human | Binding | pIC50 | = | 6.8 | 6.8 | -316 | 5 | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00164a020 | |||
| CHEMBL9506 | 210065 | None | 33 | Human | Binding | pIC50 | = | 6.8 | 6.8 | -316 | 5 | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00164a020 | |||
| 44334320 | 5025 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 531 | 9 | 2 | 4 | 4.6 | Cc1cccc(NC(=O)N[C@H](C[S+]([O-])Cc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
| CHEMBL105132 | 5025 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 531 | 9 | 2 | 4 | 4.6 | Cc1cccc(NC(=O)N[C@H](C[S+]([O-])Cc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
| CHEMBL433365 | 216099 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | None | None | None | CC(C)(C)OC(=O)N1c2ccccc2C[C@@H]1C(=O)N1[C@H](c2ccccc2)CC[C@@H]1C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O | 10.1016/S0960-894X(96)00546-X | |||||
| 196641 | 206856 | None | 11 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 447 | 3 | 1 | 3 | 4.0 | CN1C(=O)C(NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
| CHEMBL71950 | 206856 | None | 11 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 447 | 3 | 1 | 3 | 4.0 | CN1C(=O)C(NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
| 90663984 | 106870 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 841 | 21 | 8 | 8 | 3.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
| CHEMBL3144553 | 106870 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 841 | 21 | 8 | 8 | 3.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
| 90663985 | 106871 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 853 | 22 | 8 | 9 | 3.3 | COc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm00089a010 | |||
| CHEMBL3144554 | 106871 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 853 | 22 | 8 | 9 | 3.3 | COc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm00089a010 | |||
| 44279862 | 99184 | None | 0 | Mouse | Binding | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 702 | 13 | 3 | 7 | 5.9 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL281017 | 99184 | None | 0 | Mouse | Binding | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 702 | 13 | 3 | 7 | 5.9 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| 19766161 | 59201 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 403 | 4 | 3 | 3 | 3.4 | O=C(O)CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)CCc2ccccc21 | 10.1016/S0960-894X(00)80683-6 | |||
| CHEMBL170068 | 59201 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 403 | 4 | 3 | 3 | 3.4 | O=C(O)CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)CCc2ccccc21 | 10.1016/S0960-894X(00)80683-6 | |||
| 1043 | 1582 | None | 6 | Mouse | Binding | pIC50 | = | 4.8 | 4.8 | - | 27 | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/S0960-894X(00)80644-7 | |||
| 149 | 1582 | None | 6 | Mouse | Binding | pIC50 | = | 4.8 | 4.8 | - | 27 | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/S0960-894X(00)80644-7 | |||
| 8223 | 1582 | None | 6 | Mouse | Binding | pIC50 | = | 4.8 | 4.8 | - | 27 | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/S0960-894X(00)80644-7 | |||
| 8223.0 | 1582 | None | 6 | Mouse | Binding | pIC50 | = | 4.8 | 4.8 | - | 27 | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/S0960-894X(00)80644-7 | |||
| CHEMBL442 | 1582 | None | 6 | Mouse | Binding | pIC50 | = | 4.8 | 4.8 | - | 27 | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/S0960-894X(00)80644-7 | |||
| DB00696 | 1582 | None | 6 | Mouse | Binding | pIC50 | = | 4.8 | 4.8 | - | 27 | ChEMBL | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/S0960-894X(00)80644-7 | |||
| CHEMBL435339 | 216126 | None | 0 | Mouse | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1C[C@@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O | 10.1016/S0960-894X(01)80253-5 | |||||
| 14208200 | 207175 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 422 | 5 | 3 | 3 | 4.0 | O=C(CCc1c[nH]c2ccccc12)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
| CHEMBL74181 | 207175 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 422 | 5 | 3 | 3 | 4.0 | O=C(CCc1c[nH]c2ccccc12)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00120a002 | |||
| 14720390 | 49404 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 373 | 10 | 3 | 3 | 2.8 | CCCN(CCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00164a020 | |||
| CHEMBL156415 | 49404 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 373 | 10 | 3 | 3 | 2.8 | CCCN(CCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 | 10.1021/jm00164a020 | |||
| 44303653 | 100834 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 557 | 10 | 2 | 5 | 5.7 | CN(C)Cc1oc2ccccc2c1CC(C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
| CHEMBL292957 | 100834 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 557 | 10 | 2 | 5 | 5.7 | CN(C)Cc1oc2ccccc2c1CC(C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
| CHEMBL379405 | 214725 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | -10 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | |||||
| 44408411 | 161404 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | -3548 | 4 | ChEMBL | 1242 | 31 | 11 | 15 | 4.4 | CCCC[C@@H](C(=O)N[C@@H](Cc1cn(C(C)=O)c2ccccc12)C(=O)O)N(C(=O)Nc1ccccc1Cl)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)N(C)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O | 10.1021/jm050851n | |||
| CHEMBL412331 | 161404 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | -3548 | 4 | ChEMBL | 1242 | 31 | 11 | 15 | 4.4 | CCCC[C@@H](C(=O)N[C@@H](Cc1cn(C(C)=O)c2ccccc12)C(=O)O)N(C(=O)Nc1ccccc1Cl)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)N(C)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O | 10.1021/jm050851n | |||
| 10817395 | 107198 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 600 | 8 | 1 | 4 | 6.9 | COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm960249k | |||
| CHEMBL316164 | 107198 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 600 | 8 | 1 | 4 | 6.9 | COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm960249k | |||
| 10817395 | 107198 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 600 | 8 | 1 | 4 | 6.9 | COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
| CHEMBL316164 | 107198 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 600 | 8 | 1 | 4 | 6.9 | COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
| 52949124 | 876 | None | 4 | Human | Binding | pIC50 | = | 6.8 | 6.8 | 2 | 2 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| 9055 | 876 | None | 4 | Human | Binding | pIC50 | = | 6.8 | 6.8 | 2 | 2 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| CHEMBL1269258 | 876 | None | 4 | Human | Binding | pIC50 | = | 6.8 | 6.8 | 2 | 2 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| DB12694 | 876 | None | 4 | Human | Binding | pIC50 | = | 6.8 | 6.8 | 2 | 2 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| 73349808 | 161887 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 1019 | 29 | 9 | 11 | 4.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| CHEMBL414180 | 161887 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 1019 | 29 | 9 | 11 | 4.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| 44280375 | 99162 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 559 | 8 | 3 | 4 | 5.4 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1ccc(C(=O)O)cc1 | 10.1021/jm950372w | |||
| CHEMBL280832 | 99162 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 559 | 8 | 3 | 4 | 5.4 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1ccc(C(=O)O)cc1 | 10.1021/jm950372w | |||
| 10768419 | 29116 | None | 0 | Mouse | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 525 | 10 | 5 | 5 | 3.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC(CC(=O)O)CC(=O)O | 10.1021/jm970065l | |||
| CHEMBL138127 | 29116 | None | 0 | Mouse | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 525 | 10 | 5 | 5 | 3.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC(CC(=O)O)CC(=O)O | 10.1021/jm970065l | |||
| 44327699 | 209941 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 641 | 15 | 2 | 5 | 7.2 | COC(=O)CCCCCCN(CCc1ccccc1)C(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1016/S0960-894X(01)80769-1 | |||
| CHEMBL94352 | 209941 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 641 | 15 | 2 | 5 | 7.2 | COC(=O)CCCCCCN(CCc1ccccc1)C(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1016/S0960-894X(01)80769-1 | |||
| 10698051 | 208989 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 557 | 7 | 1 | 4 | 5.9 | CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm960249k | |||
| CHEMBL88545 | 208989 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 557 | 7 | 1 | 4 | 5.9 | CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm960249k | |||
| 10439504 | 92352 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 675 | 8 | 5 | 6 | 5.1 | O=C(O)c1cc(NC(=O)C2Cc3ccccc3CN2C(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1016/S0960-894X(97)00211-4 | |||
| CHEMBL24276 | 92352 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 675 | 8 | 5 | 6 | 5.1 | O=C(O)c1cc(NC(=O)C2Cc3ccccc3CN2C(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1016/S0960-894X(97)00211-4 | |||
| 10032956 | 168139 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 742 | 17 | 7 | 6 | 5.8 | Cc1ccccc1NC(=O)NCCCC[C@H](CNC(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)NC(=O)CCC(=O)O | 10.1021/jm00017a022 | |||
| CHEMBL432258 | 168139 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 742 | 17 | 7 | 6 | 5.8 | Cc1ccccc1NC(=O)NCCCC[C@H](CNC(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)NC(=O)CCC(=O)O | 10.1021/jm00017a022 | |||
| 10698051 | 208989 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 557 | 7 | 1 | 4 | 5.9 | CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm970265x | |||
| CHEMBL88545 | 208989 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 557 | 7 | 1 | 4 | 5.9 | CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm970265x | |||
| 155539345 | 172936 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 1850 | 72 | 16 | 23 | 3.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4514283 | 172936 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 1850 | 72 | 16 | 23 | 3.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 44210424 | 119282 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 423 | 4 | 2 | 4 | 3.8 | Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
| CHEMBL34335 | 119282 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 423 | 4 | 2 | 4 | 3.8 | Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
| 22354599 | 194917 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 517 | 6 | 2 | 5 | 4.9 | Cc1cccc(NC(=O)NC2N=C(c3ccncc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
| CHEMBL538912 | 194917 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 517 | 6 | 2 | 5 | 4.9 | Cc1cccc(NC(=O)NC2N=C(c3ccncc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
| 71456207 | 78655 | None | 0 | Mouse | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 655 | 12 | 5 | 7 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1c[nH]nn1)c1ccccc1 | 10.1021/jm00092a007 | |||
| CHEMBL2112331 | 78655 | None | 0 | Mouse | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 655 | 12 | 5 | 7 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1c[nH]nn1)c1ccccc1 | 10.1021/jm00092a007 | |||
| 73349808 | 161887 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 1019 | 29 | 9 | 11 | 4.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| CHEMBL414180 | 161887 | None | 0 | Rat | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 1019 | 29 | 9 | 11 | 4.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| 14888721 | 77266 | None | 0 | Bovine | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 1055 | 30 | 11 | 14 | -0.2 | CSCC[C@H](NC(=O)[C@H](Cc1ccc(Cc2nnn[nH]2)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
| CHEMBL2079551 | 77266 | None | 0 | Bovine | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 1055 | 30 | 11 | 14 | -0.2 | CSCC[C@H](NC(=O)[C@H](Cc1ccc(Cc2nnn[nH]2)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
| 44318235 | 12081 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 513 | 7 | 2 | 4 | 3.0 | CCN(CC)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C(c2cccc[n+]2C)c2ccccc21 | 10.1021/jm9608523 | |||
| CHEMBL1183721 | 12081 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 513 | 7 | 2 | 4 | 3.0 | CCN(CC)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C(c2cccc[n+]2C)c2ccccc21 | 10.1021/jm9608523 | |||
| CHEMBL314846 | 12081 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 513 | 7 | 2 | 4 | 3.0 | CCN(CC)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C(c2cccc[n+]2C)c2ccccc21 | 10.1021/jm9608523 | |||
| 44333311 | 4260 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 476 | 6 | 2 | 5 | 3.5 | CCCc1cccc(NC(=O)NC2N=C(N3CCN(C)CC3)c3ccccc3N(CCC)C2=O)c1 | 10.1016/0960-894X(95)00530-0 | |||
| CHEMBL100502 | 4260 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 476 | 6 | 2 | 5 | 3.5 | CCCc1cccc(NC(=O)NC2N=C(N3CCN(C)CC3)c3ccccc3N(CCC)C2=O)c1 | 10.1016/0960-894X(95)00530-0 | |||
| 155550030 | 174006 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 1399 | 39 | 16 | 19 | -2.7 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.9b01936 | |||
| CHEMBL4540191 | 174006 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 1399 | 39 | 16 | 19 | -2.7 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.9b01936 | |||
| 19766169 | 165661 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 443 | 4 | 2 | 4 | 4.2 | CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)CCc2ccccc21 | 10.1016/S0960-894X(00)80683-6 | |||
| CHEMBL424211 | 165661 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 443 | 4 | 2 | 4 | 4.2 | CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)CCc2ccccc21 | 10.1016/S0960-894X(00)80683-6 | |||
| 14208286 | 67705 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 395 | 4 | 1 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)/C=C/c2ccccc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
| CHEMBL1907661 | 67705 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 395 | 4 | 1 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)/C=C/c2ccccc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
| 44354127 | 116799 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 628 | 13 | 5 | 5 | 4.7 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1021/jm00105a062 | |||
| CHEMBL337461 | 116799 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 628 | 13 | 5 | 5 | 4.7 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1021/jm00105a062 | |||
| 14802522 | 59591 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 628 | 13 | 5 | 5 | 4.7 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
| CHEMBL171806 | 59591 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 628 | 13 | 5 | 5 | 4.7 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
| 44381821 | 120689 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 689 | 18 | 7 | 8 | 2.8 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@H](C#N)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(97)00107-8 | |||
| CHEMBL354632 | 120689 | None | 0 | Rat | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 689 | 18 | 7 | 8 | 2.8 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@H](C#N)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(97)00107-8 | |||
| 44280740 | 100461 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 787 | 17 | 4 | 8 | 6.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
| CHEMBL290122 | 100461 | None | 0 | Mouse | Binding | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 787 | 17 | 4 | 8 | 6.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
| 44334225 | 4990 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 522 | 7 | 2 | 6 | 3.1 | Cc1cccc(NC(=O)N[C@H](COC(=O)N2CCOCC2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
| CHEMBL104958 | 4990 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 522 | 7 | 2 | 6 | 3.1 | Cc1cccc(NC(=O)N[C@H](COC(=O)N2CCOCC2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
| 14208271 | 102950 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 455 | 3 | 1 | 3 | 4.4 | CN1C(=O)C(NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| CHEMBL305951 | 102950 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 455 | 3 | 1 | 3 | 4.4 | CN1C(=O)C(NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| 44381201 | 161770 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 1062 | 29 | 9 | 12 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)CCc1ccccc1 | 10.1016/S0960-894X(00)80679-4 | |||
| CHEMBL413186 | 161770 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 1062 | 29 | 9 | 12 | 3.6 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)CCc1ccccc1 | 10.1016/S0960-894X(00)80679-4 | |||
| 44375217 | 56568 | None | 0 | Mouse | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 582 | 12 | 5 | 7 | 3.8 | O=C(O)CN(Cc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 | 10.1016/s0960-894x(01)00044-0 | |||
| CHEMBL163974 | 56568 | None | 0 | Mouse | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 582 | 12 | 5 | 7 | 3.8 | O=C(O)CN(Cc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 | 10.1016/s0960-894x(01)00044-0 | |||
| 73349808 | 161887 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 1019 | 29 | 9 | 11 | 4.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| CHEMBL414180 | 161887 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 1019 | 29 | 9 | 11 | 4.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| 90663977 | 106856 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 823 | 21 | 8 | 8 | 3.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
| CHEMBL3144539 | 106856 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 823 | 21 | 8 | 8 | 3.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
| CHEMBL169174 | 211295 | None | 0 | Mouse | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N1CC(=O)N[C@@H](Cc2ccccc2)C1 | 10.1016/S0960-894X(01)80253-5 | |||||
| 14208199 | 103127 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 394 | 3 | 3 | 3 | 3.7 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1c[nH]c2ccccc12 | 10.1021/jm00120a002 | |||
| CHEMBL307370 | 103127 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 394 | 3 | 3 | 3 | 3.7 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1c[nH]c2ccccc12 | 10.1021/jm00120a002 | |||
| 14208246 | 207140 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 407 | 3 | 2 | 3 | 4.0 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccccc1Cl | 10.1021/jm00120a002 | |||
| CHEMBL73892 | 207140 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 407 | 3 | 2 | 3 | 4.0 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccccc1Cl | 10.1021/jm00120a002 | |||
| 10462874 | 98890 | None | 0 | Mouse | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 766 | 16 | 6 | 5 | 7.1 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCCCNC(=O)Nc1ccccc1Cl | 10.1016/S0960-894X(00)80687-3 | |||
| CHEMBL278780 | 98890 | None | 0 | Mouse | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 766 | 16 | 6 | 5 | 7.1 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCCCNC(=O)Nc1ccccc1Cl | 10.1016/S0960-894X(00)80687-3 | |||
| 44396655 | 122116 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 608 | 8 | 2 | 5 | 5.7 | C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 | 10.1021/jm0498755 | |||
| CHEMBL359589 | 122116 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 608 | 8 | 2 | 5 | 5.7 | C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 | 10.1021/jm0498755 | |||
| 44280974 | 100061 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 690 | 11 | 3 | 5 | 5.4 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2CCCCC2C1 | 10.1021/jm950372w | |||
| CHEMBL286763 | 100061 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 690 | 11 | 3 | 5 | 5.4 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2CCCCC2C1 | 10.1021/jm950372w | |||
| 44280225 | 100017 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 743 | 15 | 4 | 7 | 5.4 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL286475 | 100017 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 743 | 15 | 4 | 7 | 5.4 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| 44280620 | 103971 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 686 | 15 | 4 | 5 | 5.2 | O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCCc1ccccc1 | 10.1021/jm950372w | |||
| CHEMBL30924 | 103971 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 686 | 15 | 4 | 5 | 5.2 | O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCCc1ccccc1 | 10.1021/jm950372w | |||
| 44303511 | 159854 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 750 | 18 | 4 | 10 | 5.7 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)OCc1ccccc1)[C@@H](Cc1ccccc1)C(N)=O)n1nnnc1[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1016/S0960-894X(01)81005-2 | |||
| CHEMBL410511 | 159854 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 750 | 18 | 4 | 10 | 5.7 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)OCc1ccccc1)[C@@H](Cc1ccccc1)C(N)=O)n1nnnc1[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1016/S0960-894X(01)81005-2 | |||
| 2802894 | 2403 | None | 25 | Mouse | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 | 10.1021/jm000937a | |||
| 3509 | 2403 | None | 25 | Mouse | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 | 10.1021/jm000937a | |||
| CHEMBL333081 | 2403 | None | 25 | Mouse | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 | 10.1021/jm000937a | |||
| 71449099 | 78845 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 414 | 4 | 3 | 4 | 3.0 | CN1C(=O)[C@H](NC(=O)NCc2cccc(O)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| CHEMBL2112751 | 78845 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 414 | 4 | 3 | 4 | 3.0 | CN1C(=O)[C@H](NC(=O)NCc2cccc(O)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| 44281292 | 114858 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 816 | 17 | 5 | 9 | 5.0 | CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCNC(=O)CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
| CHEMBL33398 | 114858 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 816 | 17 | 5 | 9 | 5.0 | CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCNC(=O)CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
| 2802894 | 2403 | None | 25 | Mouse | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80684-8 | |||
| 3509 | 2403 | None | 25 | Mouse | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80684-8 | |||
| CHEMBL333081 | 2403 | None | 25 | Mouse | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 435 | 3 | 2 | 2 | 4.9 | Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80684-8 | |||
| 145979412 | 166649 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 459 | 3 | 2 | 6 | 3.9 | O=C1Nc2ccccc2/C1=N/Nc1nc2ccccc2c(=O)n1-c1cccc(Br)c1 | 10.1039/C7MD00171A | |||
| CHEMBL4279570 | 166649 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 459 | 3 | 2 | 6 | 3.9 | O=C1Nc2ccccc2/C1=N/Nc1nc2ccccc2c(=O)n1-c1cccc(Br)c1 | 10.1039/C7MD00171A | |||
| 9832467 | 144381 | None | 0 | Dog | Binding | pIC50 | = | 7.7 | 7.7 | -13 | 5 | ChEMBL | 477 | 7 | 3 | 4 | 5.9 | O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
| CHEMBL390519 | 144381 | None | 0 | Dog | Binding | pIC50 | = | 7.7 | 7.7 | -13 | 5 | ChEMBL | 477 | 7 | 3 | 4 | 5.9 | O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 | 10.1021/jm0490686 | |||
| 10319892 | 59108 | None | 1 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| CHEMBL169661 | 59108 | None | 1 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| 10838382 | 119395 | None | 0 | Mouse | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 478 | 6 | 3 | 4 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CCCCC1 | 10.1021/jm970065l | |||
| CHEMBL344211 | 119395 | None | 0 | Mouse | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 478 | 6 | 3 | 4 | 4.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CCCCC1 | 10.1021/jm970065l | |||
| 10555387 | 30102 | None | 0 | Mouse | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 589 | 10 | 3 | 3 | 7.0 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC(Cc1ccccc1)Cc1ccccc1 | 10.1021/jm970065l | |||
| CHEMBL138952 | 30102 | None | 0 | Mouse | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 589 | 10 | 3 | 3 | 7.0 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC(Cc1ccccc1)Cc1ccccc1 | 10.1021/jm970065l | |||
| 10032955 | 168138 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 742 | 17 | 7 | 6 | 5.8 | Cc1ccccc1NC(=O)NCCCC[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)NC(=O)CCC(=O)O | 10.1021/jm00017a022 | |||
| CHEMBL432256 | 168138 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 742 | 17 | 7 | 6 | 5.8 | Cc1ccccc1NC(=O)NCCCC[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)NC(=O)CCC(=O)O | 10.1021/jm00017a022 | |||
| 10093957 | 207092 | None | 1 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 426 | 3 | 2 | 3 | 3.9 | CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| CHEMBL73522 | 207092 | None | 1 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 426 | 3 | 2 | 3 | 3.9 | CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| 73351326 | 82415 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 1017 | 29 | 9 | 10 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| CHEMBL217234 | 82415 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 1017 | 29 | 9 | 10 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| 14843053 | 100214 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 409 | 4 | 1 | 5 | 4.4 | O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1ccc2c(c1)OCO2 | 10.1021/jm00108a040 | |||
| CHEMBL287913 | 100214 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 409 | 4 | 1 | 5 | 4.4 | O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1ccc2c(c1)OCO2 | 10.1021/jm00108a040 | |||
| 10369346 | 24976 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 518 | 6 | 3 | 5 | 4.4 | Cc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)Nc3ccncc3)C2=O)cc1 | 10.1021/jm00078a018 | |||
| CHEMBL134618 | 24976 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 518 | 6 | 3 | 5 | 4.4 | Cc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)Nc3ccncc3)C2=O)cc1 | 10.1021/jm00078a018 | |||
| 44370694 | 48024 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 488 | 15 | 2 | 4 | 4.8 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)N1CCCC1)NC(=O)Nc1cccc(OC)c1 | 10.1021/jm00164a020 | |||
| CHEMBL155017 | 48024 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 488 | 15 | 2 | 4 | 4.8 | CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)N1CCCC1)NC(=O)Nc1cccc(OC)c1 | 10.1021/jm00164a020 | |||
| 44329331 | 108121 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 540 | 6 | 3 | 3 | 5.9 | Cc1ccc([C@H]2C[C@@H](NC(=O)Nc3cccc(C)c3)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c3ccccc3)C2)cc1 | 10.1016/S0960-894X(01)80832-5 | |||
| CHEMBL319504 | 108121 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 540 | 6 | 3 | 3 | 5.9 | Cc1ccc([C@H]2C[C@@H](NC(=O)Nc3cccc(C)c3)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c3ccccc3)C2)cc1 | 10.1016/S0960-894X(01)80832-5 | |||
| 44280713 | 100086 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 740 | 15 | 6 | 9 | 3.6 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL286907 | 100086 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 740 | 15 | 6 | 9 | 3.6 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| 10769675 | 209657 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 587 | 8 | 1 | 5 | 5.9 | COc1cccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)c1 | 10.1021/jm970265x | |||
| CHEMBL92586 | 209657 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 587 | 8 | 1 | 5 | 5.9 | COc1cccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)c1 | 10.1021/jm970265x | |||
| CHEMBL319340 | 213675 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||||
| CHEMBL2112688 | 211707 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)[C@H](C)c1c[nH]c2ccccc12 | 10.1021/jm960078j | |||||
| CHEMBL98468 | 218417 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | None | None | None | Cc1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 | 10.1021/jm00113a023 | |||||
| 14208242 | 156514 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 493 | 6 | 1 | 5 | 4.0 | CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00121a004 | |||
| CHEMBL40668 | 156514 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 493 | 6 | 1 | 5 | 4.0 | CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00121a004 | |||
| CHEMBL98468 | 218417 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | None | None | None | Cc1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 | 10.1021/jm960509y | |||||
| CHEMBL103485 | 210916 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | None | None | None | CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00173a006 | |||||
| CHEMBL319340 | 213675 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00173a006 | |||||
| CHEMBL98468 | 218417 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | None | None | None | Cc1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 | 10.1021/jm00173a006 | |||||
| 14208268 | 206942 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 418 | 3 | 2 | 4 | 3.5 | CN1C(=O)C(NC(=O)c2ccc(Cl)cc2N)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
| CHEMBL72428 | 206942 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 418 | 3 | 2 | 4 | 3.5 | CN1C(=O)C(NC(=O)c2ccc(Cl)cc2N)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
| 44375675 | 56522 | None | 0 | Mouse | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 605 | 12 | 4 | 7 | 4.9 | O=C(O)CN(Cc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1016/s0960-894x(01)00044-0 | |||
| CHEMBL163506 | 56522 | None | 0 | Mouse | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 605 | 12 | 4 | 7 | 4.9 | O=C(O)CN(Cc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1016/s0960-894x(01)00044-0 | |||
| CHEMBL319340 | 213675 | None | 0 | Mouse | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80687-3 | |||||
| 15104620 | 111423 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 476 | 13 | 3 | 2 | 6.4 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccc(C)cc1 | 10.1021/jm00116a002 | |||
| CHEMBL326979 | 111423 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 476 | 13 | 3 | 2 | 6.4 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccc(C)cc1 | 10.1021/jm00116a002 | |||
| 14208242 | 156514 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 493 | 6 | 1 | 5 | 4.0 | CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00078a018 | |||
| CHEMBL40668 | 156514 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 493 | 6 | 1 | 5 | 4.0 | CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00078a018 | |||
| 3960 | 2345 | None | 18 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 10.1021/jm00164a020 | |||
| 891 | 2345 | None | 18 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 10.1021/jm00164a020 | |||
| CHEMBL24938 | 2345 | None | 18 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 10.1021/jm00164a020 | |||
| 44349434 | 117079 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 396 | 11 | 3 | 3 | 3.6 | CCC(C)(CC)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 | 10.1021/jm00079a003 | |||
| CHEMBL338929 | 117079 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 396 | 11 | 3 | 3 | 3.6 | CCC(C)(CC)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 | 10.1021/jm00079a003 | |||
| 44349087 | 118513 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 420 | 7 | 3 | 3 | 3.8 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCC2CCCCC2C1 | 10.1021/jm00079a003 | |||
| CHEMBL341143 | 118513 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 420 | 7 | 3 | 3 | 3.8 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCC2CCCCC2C1 | 10.1021/jm00079a003 | |||
| 44382329 | 120690 | None | 1 | Mouse | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 475 | 3 | 2 | 2 | 5.9 | O=C1NN(C(=S)Nc2ccc(Cl)c(C(F)(F)F)c2)[C@H](c2ccccc2)[C@H]1c1ccccc1 | 10.1016/S0960-894X(00)80684-8 | |||
| CHEMBL354633 | 120690 | None | 1 | Mouse | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 475 | 3 | 2 | 2 | 5.9 | O=C1NN(C(=S)Nc2ccc(Cl)c(C(F)(F)F)c2)[C@H](c2ccccc2)[C@H]1c1ccccc1 | 10.1016/S0960-894X(00)80684-8 | |||
| 14208299 | 67763 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 465 | 3 | 1 | 3 | 4.2 | CN1C(=O)[C@@H](NC(=O)c2ccccc2Br)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| CHEMBL1907844 | 67763 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 465 | 3 | 1 | 3 | 4.2 | CN1C(=O)[C@@H](NC(=O)c2ccccc2Br)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| 14208253 | 207167 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 389 | 3 | 2 | 3 | 3.9 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cccc(Cl)c1 | 10.1021/jm00120a002 | |||
| CHEMBL74125 | 207167 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 389 | 3 | 2 | 3 | 3.9 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cccc(Cl)c1 | 10.1021/jm00120a002 | |||
| 14991542 | 106863 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 893 | 22 | 8 | 8 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
| CHEMBL3144545 | 106863 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 893 | 22 | 8 | 8 | 4.2 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
| 44349353 | 116906 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 415 | 7 | 3 | 4 | 3.0 | Cc1cc(C)cc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 | 10.1021/jm00079a003 | |||
| CHEMBL338045 | 116906 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 415 | 7 | 3 | 4 | 3.0 | Cc1cc(C)cc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 | 10.1021/jm00079a003 | |||
| 10530400 | 119399 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 535 | 7 | 3 | 5 | 5.0 | COC(=O)C1(NC(=O)[C@@](C)(Cc2c[nH]c3ccccc23)NC(=O)OC2C3CC4CC(C3)CC2C4)CCCCC1 | 10.1021/jm970065l | |||
| CHEMBL344220 | 119399 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 535 | 7 | 3 | 5 | 5.0 | COC(=O)C1(NC(=O)[C@@](C)(Cc2c[nH]c3ccccc23)NC(=O)OC2C3CC4CC(C3)CC2C4)CCCCC1 | 10.1021/jm970065l | |||
| 44303669 | 168392 | None | 0 | Mouse | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 573 | 10 | 4 | 5 | 3.9 | O=C(O)CCC(=O)N[C@@H](CNC(=O)C1(NC(=O)OC2C3CC4CC(C3)CC2C4)Cc2ccccc2C1)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
| CHEMBL434020 | 168392 | None | 0 | Mouse | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 573 | 10 | 4 | 5 | 3.9 | O=C(O)CCC(=O)N[C@@H](CNC(=O)C1(NC(=O)OC2C3CC4CC(C3)CC2C4)Cc2ccccc2C1)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
| 10344702 | 28638 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 471 | 7 | 2 | 5 | 3.6 | COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCN(C)C)C2=O)c1 | 10.1021/jm00078a018 | |||
| CHEMBL137714 | 28638 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 471 | 7 | 2 | 5 | 3.6 | COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCN(C)C)C2=O)c1 | 10.1021/jm00078a018 | |||
| 44283085 | 99960 | None | 0 | Mouse | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 484 | 9 | 2 | 2 | 7.4 | CC(CCCCc1ccccc1)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
| CHEMBL286093 | 99960 | None | 0 | Mouse | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 484 | 9 | 2 | 2 | 7.4 | CC(CCCCc1ccccc1)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
| 44283151 | 119231 | None | 0 | Mouse | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 531 | 9 | 4 | 4 | 5.6 | O=C(NC(Cc1c[nH]c2ccccc12)/C(S)=N/C(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
| CHEMBL34300 | 119231 | None | 0 | Mouse | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 531 | 9 | 4 | 4 | 5.6 | O=C(NC(Cc1c[nH]c2ccccc12)/C(S)=N/C(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | 10.1021/jm00086a017 | |||
| 44365788 | 121758 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 643 | 7 | 1 | 7 | 5.5 | COC(=O)n1c(C(=O)NC2C(=O)N(CC(=O)N(c3ccccc3)C(C)C)c3ccccc3N(c3ccccc3)C2=O)cc2ccccc21 | 10.1021/jm9601664 | |||
| CHEMBL358778 | 121758 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 643 | 7 | 1 | 7 | 5.5 | COC(=O)n1c(C(=O)NC2C(=O)N(CC(=O)N(c3ccccc3)C(C)C)c3ccccc3N(c3ccccc3)C2=O)cc2ccccc21 | 10.1021/jm9601664 | |||
| CHEMBL1172428 | 211045 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | -47 | 3 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2010.05.078 | |||||
| CHEMBL1172429 | 211046 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | -120 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2010.05.078 | |||||
| CHEMBL2372623 | 212736 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | -218 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.bmcl.2010.05.078 | |||||
| 21842345 | 121768 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 522 | 6 | 2 | 4 | 5.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCCCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
| CHEMBL358875 | 121768 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 522 | 6 | 2 | 4 | 5.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCCCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
| 5311201 | 209854 | None | 26 | Human | Binding | pIC50 | = | 8.7 | 8.7 | -27 | 9 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00121a004 | |||
| CHEMBL9387 | 209854 | None | 26 | Human | Binding | pIC50 | = | 8.7 | 8.7 | -27 | 9 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00121a004 | |||
| 5311201 | 209854 | None | 26 | Human | Binding | pIC50 | = | 8.7 | 8.7 | -27 | 9 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm970517u | |||
| CHEMBL9387 | 209854 | None | 26 | Human | Binding | pIC50 | = | 8.7 | 8.7 | -27 | 9 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm970517u | |||
| 5311201 | 209854 | None | 26 | Mouse | Binding | pIC50 | = | 8.7 | 8.7 | -26 | 9 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm000937a | |||
| CHEMBL9387 | 209854 | None | 26 | Mouse | Binding | pIC50 | = | 8.7 | 8.7 | -26 | 9 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm000937a | |||
| 10053201 | 16599 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 546 | 6 | 3 | 3 | 5.9 | CCc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 | 10.1021/jm00048a015 | |||
| CHEMBL124004 | 16599 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 546 | 6 | 3 | 3 | 5.9 | CCc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 | 10.1021/jm00048a015 | |||
| 5311201 | 209854 | None | 26 | Human | Binding | pIC50 | = | 8.7 | 8.7 | -27 | 9 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm020424z | |||
| CHEMBL9387 | 209854 | None | 26 | Human | Binding | pIC50 | = | 8.7 | 8.7 | -27 | 9 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm020424z | |||
| CHEMBL274661 | 213274 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)OCCc1ccccc1 | 10.1021/jm00072a024 | |||||
| CHEMBL274661 | 213274 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)OCCc1ccccc1 | 10.1021/jm00072a024 | |||||
| 44293811 | 185225 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 601 | 5 | 2 | 4 | 5.8 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(Cl)c1)N=C2c1ccccc1F | 10.1016/S0960-894X(96)00609-9 | |||
| CHEMBL48563 | 185225 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 601 | 5 | 2 | 4 | 5.8 | Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(Cl)c1)N=C2c1ccccc1F | 10.1016/S0960-894X(96)00609-9 | |||
| 5311201 | 209854 | None | 26 | Human | Binding | pIC50 | = | 8.7 | 8.7 | -27 | 9 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00609-9 | |||
| CHEMBL9387 | 209854 | None | 26 | Human | Binding | pIC50 | = | 8.7 | 8.7 | -27 | 9 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00609-9 | |||
| 5311201 | 209854 | None | 26 | Human | Binding | pIC50 | = | 8.7 | 8.7 | -27 | 9 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/np9800102 | |||
| CHEMBL9387 | 209854 | None | 26 | Human | Binding | pIC50 | = | 8.7 | 8.7 | -27 | 9 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/np9800102 | |||
| 5311201 | 209854 | None | 26 | Human | Binding | pIC50 | = | 8.7 | 8.7 | -27 | 9 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(00)80684-8 | |||
| CHEMBL9387 | 209854 | None | 26 | Human | Binding | pIC50 | = | 8.7 | 8.7 | -27 | 9 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(00)80684-8 | |||
| 145979415 | 166654 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 509 | 6 | 3 | 6 | 4.9 | CCOc1ccc(-n2c(NNC(=S)Nc3ccc(Br)cc3)nc3ccccc3c2=O)cc1 | 10.1039/C7MD00171A | |||
| CHEMBL4279660 | 166654 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 509 | 6 | 3 | 6 | 4.9 | CCOc1ccc(-n2c(NNC(=S)Nc3ccc(Br)cc3)nc3ccccc3c2=O)cc1 | 10.1039/C7MD00171A | |||
| 155526914 | 171305 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 1837 | 72 | 19 | 24 | 0.8 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4459331 | 171305 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 1837 | 72 | 19 | 24 | 0.8 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 21842327 | 46057 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 468 | 6 | 2 | 4 | 4.6 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)C)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
| CHEMBL153308 | 46057 | None | 0 | Rat | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 468 | 6 | 2 | 4 | 4.6 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)C)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
| 155532425 | 171851 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 1822 | 71 | 18 | 23 | 2.5 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4467338 | 171851 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 1822 | 71 | 18 | 23 | 2.5 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL407057 | 215095 | None | 1 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 120 | 4 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O | 10.1021/jm050921q | |||||
| 10369804 | 16767 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 532 | 5 | 3 | 3 | 5.6 | Cc1cccc2c1N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 | 10.1021/jm00048a015 | |||
| CHEMBL124340 | 16767 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 532 | 5 | 3 | 3 | 5.6 | Cc1cccc2c1N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 | 10.1021/jm00048a015 | |||
| 44349572 | 115123 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 533 | 5 | 2 | 4 | 6.0 | Cc1ccc2c(c1)N(CC(=O)OC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 | 10.1021/jm00048a015 | |||
| CHEMBL334305 | 115123 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 533 | 5 | 2 | 4 | 6.0 | Cc1ccc2c(c1)N(CC(=O)OC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 | 10.1021/jm00048a015 | |||
| 10431936 | 93291 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 414 | 4 | 2 | 4 | 3.7 | COc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
| CHEMBL2448131 | 93291 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 414 | 4 | 2 | 4 | 3.7 | COc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
| CHEMBL384035 | 214776 | None | 3 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | -512 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80679-4 | |||||
| CHEMBL428666 | 214776 | None | 3 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | -512 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80679-4 | |||||
| CHEMBL384035 | 214776 | None | 3 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | -512 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00072a024 | |||||
| CHEMBL428666 | 214776 | None | 3 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | -512 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00072a024 | |||||
| 44332065 | 109771 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 552 | 13 | 3 | 4 | 4.3 | CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCC1CCCCC1)CC(=O)N1CCC[C@H]1C(=O)O | 10.1016/S0960-894X(96)00546-X | |||
| CHEMBL322893 | 109771 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 552 | 13 | 3 | 4 | 4.3 | CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCC1CCCCC1)CC(=O)N1CCC[C@H]1C(=O)O | 10.1016/S0960-894X(96)00546-X | |||
| 44327450 | 168304 | None | 0 | Mouse | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 558 | 10 | 3 | 5 | 4.6 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccn1)CC(=O)O | 10.1016/S0960-894X(01)80769-1 | |||
| CHEMBL433384 | 168304 | None | 0 | Mouse | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 558 | 10 | 3 | 5 | 4.6 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccn1)CC(=O)O | 10.1016/S0960-894X(01)80769-1 | |||
| 21842336 | 121582 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 480 | 6 | 2 | 4 | 4.7 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
| CHEMBL358420 | 121582 | None | 0 | Rat | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 480 | 6 | 2 | 4 | 4.7 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCC3)C2=O)c1 | 10.1016/0960-894X(95)00556-9 | |||
| 11799907 | 97052 | None | 0 | Mouse | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 511 | 6 | 3 | 7 | 5.0 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)c(Cl)c2)c1 | 10.1021/jm970373j | |||
| CHEMBL266557 | 97052 | None | 0 | Mouse | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 511 | 6 | 3 | 7 | 5.0 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)c(Cl)c2)c1 | 10.1021/jm970373j | |||
| CHEMBL1806531 | 211435 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm101279a | |||||
| CHEMBL1806532 | 211436 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm101279a | |||||
| 71458004 | 78659 | None | 0 | Mouse | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 670 | 12 | 5 | 8 | 4.7 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCn1nn[nH]c1=S)c1ccccc1 | 10.1021/jm00092a007 | |||
| CHEMBL2112335 | 78659 | None | 0 | Mouse | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 670 | 12 | 5 | 8 | 4.7 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCn1nn[nH]c1=S)c1ccccc1 | 10.1021/jm00092a007 | |||
| 44318205 | 208252 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 459 | 3 | 3 | 4 | 3.9 | CN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)CCC3)N=C([C@H]2CC(C)(C)CCN2)c2ccccc21 | 10.1021/jm9608523 | |||
| CHEMBL83130 | 208252 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 459 | 3 | 3 | 4 | 3.9 | CN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)CCC3)N=C([C@H]2CC(C)(C)CCN2)c2ccccc21 | 10.1021/jm9608523 | |||
| CHEMBL120632 | 211064 | None | 28 | Mouse | Binding | pIC50 | = | 8.6 | 8.6 | - | 3 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/0960-894X(94)85022-4 | |||||
| 56663263 | 64039 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 1538 | 51 | 14 | 25 | -2.8 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NCCOCCOCCOCCOCCOCCOC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm101279a | |||
| CHEMBL1807150 | 64039 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 1538 | 51 | 14 | 25 | -2.8 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NCCOCCOCCOCCOCCOCCOC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm101279a | |||
| 71454457 | 78654 | None | 0 | Mouse | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 655 | 12 | 5 | 7 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1nc[nH]n1)c1ccccc1 | 10.1021/jm00092a007 | |||
| CHEMBL2112330 | 78654 | None | 0 | Mouse | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 655 | 12 | 5 | 7 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1nc[nH]n1)c1ccccc1 | 10.1021/jm00092a007 | |||
| 10458620 | 114610 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 499 | 5 | 2 | 4 | 5.4 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 | 10.1021/jm00048a015 | |||
| CHEMBL333718 | 114610 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 499 | 5 | 2 | 4 | 5.4 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 | 10.1021/jm00048a015 | |||
| 10625474 | 29234 | None | 0 | Mouse | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 508 | 8 | 3 | 5 | 4.2 | COC[C@H]1CCCN1NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1021/jm970065l | |||
| CHEMBL138233 | 29234 | None | 0 | Mouse | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 508 | 8 | 3 | 5 | 4.2 | COC[C@H]1CCCN1NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1021/jm970065l | |||
| 171345545 | 193880 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 1219 | 24 | 15 | 16 | -0.0 | CSCCC[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCCNC(=O)[C@H](NC(=O)c2ccc(NN)nc2)CCC(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.ejmech.2021.113538 | |||
| CHEMBL5273681 | 193880 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 1219 | 24 | 15 | 16 | -0.0 | CSCCC[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCCNC(=O)[C@H](NC(=O)c2ccc(NN)nc2)CCC(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.ejmech.2021.113538 | |||
| 10392653 | 119105 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 544 | 5 | 2 | 5 | 3.4 | CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3ccc(Cl)cc3)N=C(c3ccccc3)c3ccccc32)CC1 | 10.1016/S0960-894X(00)80683-6 | |||
| CHEMBL342640 | 119105 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 544 | 5 | 2 | 5 | 3.4 | CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3ccc(Cl)cc3)N=C(c3ccccc3)c3ccccc32)CC1 | 10.1016/S0960-894X(00)80683-6 | |||
| 71449079 | 78658 | None | 0 | Mouse | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 639 | 11 | 5 | 7 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)Cc1cc(O)no1)c1ccccc1 | 10.1021/jm00092a007 | |||
| CHEMBL2112334 | 78658 | None | 0 | Mouse | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 639 | 11 | 5 | 7 | 4.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)Cc1cc(O)no1)c1ccccc1 | 10.1021/jm00092a007 | |||
| 14802530 | 21624 | None | 0 | Mouse | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 614 | 12 | 5 | 5 | 4.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CC(=O)O)Cc1ccccc1 | 10.1021/jm00105a062 | |||
| CHEMBL131754 | 21624 | None | 0 | Mouse | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 614 | 12 | 5 | 5 | 4.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CC(=O)O)Cc1ccccc1 | 10.1021/jm00105a062 | |||
| CHEMBL205965 | 211628 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | 31 | 3 | ChEMBL | None | None | None | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1 | 10.1021/jm050921q | |||||
| 44300744 | 102008 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 542 | 6 | 4 | 4 | 4.7 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)O)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
| CHEMBL301261 | 102008 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 542 | 6 | 4 | 4 | 4.7 | Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)O)c1)C[C@@H]2c1ccccc1 | 10.1016/0960-894X(95)00327-P | |||
| 10003805 | 107520 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 448 | 4 | 2 | 5 | 2.9 | CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C(N2CCN(C)CC2)c2ccccc21 | 10.1016/0960-894X(95)00530-0 | |||
| CHEMBL318360 | 107520 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 448 | 4 | 2 | 5 | 2.9 | CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C(N2CCN(C)CC2)c2ccccc21 | 10.1016/0960-894X(95)00530-0 | |||
| 51353551 | 18141 | None | 18 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
| CHEMBL1269257 | 18141 | None | 18 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 605 | 8 | 3 | 5 | 5.0 | CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/j.bmcl.2015.03.051 | |||
| 19018662 | 26520 | None | 14 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 424 | 3 | 2 | 3 | 4.1 | CN1C(=O)C(NC(=O)Nc2ccc3c(c2)CCC3)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| CHEMBL136038 | 26520 | None | 14 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 424 | 3 | 2 | 3 | 4.1 | CN1C(=O)C(NC(=O)Nc2ccc3c(c2)CCC3)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| CHEMBL2369762 | 212139 | None | 0 | Mouse | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | None | None | None | CCCCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/0960-894X(94)85022-4 | |||||
| 5311201 | 209854 | None | 26 | Human | Binding | pIC50 | = | 8.5 | 8.5 | -27 | 9 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00108a040 | |||
| CHEMBL9387 | 209854 | None | 26 | Human | Binding | pIC50 | = | 8.5 | 8.5 | -27 | 9 | ChEMBL | 398 | 3 | 2 | 3 | 4.0 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00108a040 | |||
| 10815094 | 120463 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 495 | 5 | 3 | 7 | 3.2 | Cc1ccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1N(C)c1nn[nH]n1 | 10.1021/jm9506736 | |||
| CHEMBL353509 | 120463 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 495 | 5 | 3 | 7 | 3.2 | Cc1ccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1N(C)c1nn[nH]n1 | 10.1021/jm9506736 | |||
| 44280599 | 99216 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 694 | 12 | 4 | 5 | 6.2 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 | 10.1021/jm950372w | |||
| CHEMBL281206 | 99216 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 694 | 12 | 4 | 5 | 6.2 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 | 10.1021/jm950372w | |||
| 44336539 | 5146 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
| CHEMBL105775 | 5146 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 563 | 7 | 2 | 5 | 4.6 | COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 | 10.1016/j.bmcl.2015.03.051 | |||
| 155536224 | 172262 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 1409 | 38 | 15 | 21 | -2.1 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)n1cc([C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.9b01936 | |||
| CHEMBL4473301 | 172262 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 1409 | 38 | 15 | 21 | -2.1 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)n1cc([C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.9b01936 | |||
| 10501974 | 97028 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 415 | 5 | 3 | 6 | 3.9 | COc1cccc(-n2c(NNC(=O)Nc3cccc(C)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
| CHEMBL266376 | 97028 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 415 | 5 | 3 | 6 | 3.9 | COc1cccc(-n2c(NNC(=O)Nc3cccc(C)c3)nc3ccccc3c2=O)c1 | 10.1021/jm970373j | |||
| CHEMBL411202 | 215333 | None | 0 | Bovine | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00100a033 | |||||
| 44349069 | 118123 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 455 | 7 | 3 | 4 | 3.6 | O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
| CHEMBL340413 | 118123 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 455 | 7 | 3 | 4 | 3.6 | O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
| 73351327 | 82457 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 1019 | 29 | 9 | 11 | 4.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| CHEMBL217424 | 82457 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 1019 | 29 | 9 | 11 | 4.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| 14888714 | 77278 | None | 0 | Bovine | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 1067 | 30 | 11 | 12 | 0.9 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(C(F)(F)C(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
| CHEMBL2079602 | 77278 | None | 0 | Bovine | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 1067 | 30 | 11 | 12 | 0.9 | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(C(F)(F)C(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
| 44303298 | 205759 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 522 | 9 | 5 | 6 | 3.5 | CC(Cc1ccc(O)cc1)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
| CHEMBL64770 | 205759 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 522 | 9 | 5 | 6 | 3.5 | CC(Cc1ccc(O)cc1)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
| 14991572 | 163275 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 848 | 20 | 8 | 9 | 3.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cnc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
| CHEMBL418123 | 163275 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 848 | 20 | 8 | 9 | 3.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cnc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
| 44348808 | 17942 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 451 | 7 | 3 | 4 | 3.9 | O=C(O)CCC(NC(=O)c1ccc2ccccc2c1)C(=O)NN1CCC2(CCCCC2)CC1 | 10.1021/jm00079a003 | |||
| CHEMBL125925 | 17942 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 451 | 7 | 3 | 4 | 3.9 | O=C(O)CCC(NC(=O)c1ccc2ccccc2c1)C(=O)NN1CCC2(CCCCC2)CC1 | 10.1021/jm00079a003 | |||
| 44280996 | 99798 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 745 | 14 | 4 | 8 | 5.4 | CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
| CHEMBL284976 | 99798 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 745 | 14 | 4 | 8 | 5.4 | CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
| 44279861 | 103239 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 726 | 14 | 6 | 9 | 3.1 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL30821 | 103239 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 726 | 14 | 6 | 9 | 3.1 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
| 44280373 | 99442 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 773 | 16 | 4 | 8 | 5.4 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL282646 | 99442 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 773 | 16 | 4 | 8 | 5.4 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| 155523323 | 170891 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 1409 | 38 | 16 | 20 | -2.1 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)c1c[nH]nn1 | 10.1021/acs.jmedchem.9b01936 | |||
| CHEMBL4453047 | 170891 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 1409 | 38 | 16 | 20 | -2.1 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)c1c[nH]nn1 | 10.1021/acs.jmedchem.9b01936 | |||
| CHEMBL3142681 | 213585 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | None | None | None | Cc1ccccc1NC(=O)NCCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||||
| CHEMBL3142698 | 213593 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | None | None | None | Cc1ccccc1/N=C(/S)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||||
| 44349314 | 16574 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 402 | 8 | 3 | 3 | 3.5 | CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cc(Cl)cc(Cl)c1 | 10.1021/jm00079a003 | |||
| CHEMBL123852 | 16574 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 402 | 8 | 3 | 3 | 3.5 | CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cc(Cl)cc(Cl)c1 | 10.1021/jm00079a003 | |||
| 44458120 | 99015 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 377 | 5 | 3 | 3 | 2.0 | O=C(N[C@@H]1C(=O)N(Cc2ccccc2)C[C@@H]1C(=O)O)c1cc2ccccc2[nH]1 | 10.1016/S0960-894X(00)80224-3 | |||
| CHEMBL279730 | 99015 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 377 | 5 | 3 | 3 | 2.0 | O=C(N[C@@H]1C(=O)N(Cc2ccccc2)C[C@@H]1C(=O)O)c1cc2ccccc2[nH]1 | 10.1016/S0960-894X(00)80224-3 | |||
| 14208305 | 67765 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 513 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@H](NC(=O)c2cccc(I)c2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| CHEMBL1907846 | 67765 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 513 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@H](NC(=O)c2cccc(I)c2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| 14208231 | 206704 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 422 | 3 | 1 | 4 | 3.7 | CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
| CHEMBL71079 | 206704 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 422 | 3 | 1 | 4 | 3.7 | CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
| 14444022 | 106730 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 692 | 17 | 7 | 7 | 2.7 | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/jm00123a003 | |||
| CHEMBL3143385 | 106730 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 692 | 17 | 7 | 7 | 2.7 | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1021/jm00123a003 | |||
| 44365965 | 121765 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 649 | 16 | 6 | 6 | 3.8 | CC(C)CC(CC(=O)N[C@H](CC(=O)O)C(=O)NCCc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm00123a003 | |||
| CHEMBL358826 | 121765 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 649 | 16 | 6 | 6 | 3.8 | CC(C)CC(CC(=O)N[C@H](CC(=O)O)C(=O)NCCc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm00123a003 | |||
| 44334258 | 4466 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 451 | 8 | 3 | 4 | 3.5 | Cc1cccc(NC(=O)N[C@H](CCC(=O)O)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
| CHEMBL101752 | 4466 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 451 | 8 | 3 | 4 | 3.5 | Cc1cccc(NC(=O)N[C@H](CCC(=O)O)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
| 44334172 | 4571 | None | 1 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 556 | 10 | 3 | 5 | 4.9 | Cc1cccc(NC(=O)N[C@H](CCC(=O)OCc2ccccc2)C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
| CHEMBL102526 | 4571 | None | 1 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 556 | 10 | 3 | 5 | 4.9 | Cc1cccc(NC(=O)N[C@H](CCC(=O)OCc2ccccc2)C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
| 14208231 | 206704 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 422 | 3 | 1 | 4 | 3.7 | CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
| CHEMBL71079 | 206704 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 422 | 3 | 1 | 4 | 3.7 | CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
| 14208230 | 103264 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 446 | 3 | 3 | 3 | 4.5 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(Cl)ccc2[nH]1 | 10.1021/jm00120a002 | |||
| CHEMBL308414 | 103264 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 446 | 3 | 3 | 3 | 4.5 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(Cl)ccc2[nH]1 | 10.1021/jm00120a002 | |||
| 44365993 | 44198 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 635 | 15 | 6 | 6 | 3.8 | CC(C)C[C@@H](CC(=O)NC(CC(=O)O)C(=O)NCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm00123a003 | |||
| CHEMBL151619 | 44198 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 635 | 15 | 6 | 6 | 3.8 | CC(C)C[C@@H](CC(=O)NC(CC(=O)O)C(=O)NCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm00123a003 | |||
| 15104613 | 110371 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 486 | 13 | 3 | 2 | 6.2 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm00116a002 | |||
| CHEMBL323854 | 110371 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 486 | 13 | 3 | 2 | 6.2 | CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1c[nH]c2ccccc12 | 10.1021/jm00116a002 | |||
| 10076650 | 26240 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 566 | 8 | 4 | 5 | 3.5 | O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 | 10.1021/jm050689o | |||
| CHEMBL13577 | 26240 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 566 | 8 | 4 | 5 | 3.5 | O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 | 10.1021/jm050689o | |||
| 10076650 | 26240 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 566 | 8 | 4 | 5 | 3.5 | O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 | 10.1021/jm000959x | |||
| CHEMBL13577 | 26240 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 566 | 8 | 4 | 5 | 3.5 | O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 | 10.1021/jm000959x | |||
| 10076650 | 26240 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 566 | 8 | 4 | 5 | 3.5 | O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 | 10.1016/s0960-894x(01)00630-8 | |||
| CHEMBL13577 | 26240 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 566 | 8 | 4 | 5 | 3.5 | O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 | 10.1016/s0960-894x(01)00630-8 | |||
| 44329486 | 112662 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 544 | 6 | 3 | 3 | 5.7 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3ccc(F)cc3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
| CHEMBL330197 | 112662 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 544 | 6 | 3 | 3 | 5.7 | Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3ccc(F)cc3)N(CC(=O)NC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(01)80832-5 | |||
| 44303651 | 202937 | None | 0 | Mouse | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 458 | 6 | 2 | 3 | 4.4 | O=C(NC1(C(=O)NCCc2ccccc2)Cc2ccccc2C1)OC1C2CC3CC(C2)CC1C3 | 10.1016/S0960-894X(97)00356-9 | |||
| CHEMBL59859 | 202937 | None | 0 | Mouse | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 458 | 6 | 2 | 3 | 4.4 | O=C(NC1(C(=O)NCCc2ccccc2)Cc2ccccc2C1)OC1C2CC3CC(C2)CC1C3 | 10.1016/S0960-894X(97)00356-9 | |||
| 155562281 | 175945 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 1900 | 71 | 16 | 23 | 4.4 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4585323 | 175945 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 1900 | 71 | 16 | 23 | 4.4 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 73351326 | 82415 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 1017 | 29 | 9 | 10 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| CHEMBL217234 | 82415 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 1017 | 29 | 9 | 10 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| 44279810 | 103899 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 757 | 16 | 4 | 7 | 5.7 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL30917 | 103899 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 757 | 16 | 4 | 7 | 5.7 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
| 52949124 | 876 | None | 4 | Human | Binding | pIC50 | = | 6.7 | 6.7 | 2 | 2 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| 9055 | 876 | None | 4 | Human | Binding | pIC50 | = | 6.7 | 6.7 | 2 | 2 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| CHEMBL1269258 | 876 | None | 4 | Human | Binding | pIC50 | = | 6.7 | 6.7 | 2 | 2 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| DB12694 | 876 | None | 4 | Human | Binding | pIC50 | = | 6.7 | 6.7 | 2 | 2 | ChEMBL | 594 | 8 | 1 | 5 | 6.5 | CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C | 10.1021/acs.jmedchem.5b01110 | |||
| 44353183 | 116840 | None | 0 | Mouse | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 555 | 8 | 3 | 4 | 5.2 | O=C(OC1C2CC3CC(C2)CC1C3)N1CCCC1(Cc1c[nH]c2ccccc12)C(=O)NC(CO)Cc1ccccc1 | 10.1016/S0960-894X(00)80156-0 | |||
| CHEMBL337692 | 116840 | None | 0 | Mouse | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 555 | 8 | 3 | 4 | 5.2 | O=C(OC1C2CC3CC(C2)CC1C3)N1CCCC1(Cc1c[nH]c2ccccc12)C(=O)NC(CO)Cc1ccccc1 | 10.1016/S0960-894X(00)80156-0 | |||
| 44349411 | 16850 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 380 | 7 | 3 | 3 | 3.1 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCCCCC1 | 10.1021/jm00079a003 | |||
| CHEMBL124802 | 16850 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 380 | 7 | 3 | 3 | 3.1 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCCCCC1 | 10.1021/jm00079a003 | |||
| 73354295 | 106002 | None | 0 | Mouse | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 643 | 13 | 5 | 6 | 4.5 | CONC(=O)CCC(=O)N[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 | 10.1021/jm00092a007 | |||
| CHEMBL312894 | 106002 | None | 0 | Mouse | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 643 | 13 | 5 | 6 | 4.5 | CONC(=O)CCC(=O)N[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 | 10.1021/jm00092a007 | |||
| 10256428 | 119752 | None | 0 | Mouse | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 529 | 9 | 4 | 4 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL347278 | 119752 | None | 0 | Mouse | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 529 | 9 | 4 | 4 | 4.9 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL386811 | 214853 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)OCCc1ccccc1 | 10.1021/jm00072a024 | |||||
| 44368329 | 121067 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 499 | 8 | 3 | 3 | 5.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C(=O)NCCc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL356446 | 121067 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 499 | 8 | 3 | 3 | 5.5 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C(=O)NCCc1ccccc1 | 10.1021/jm00057a005 | |||
| 90663976 | 106855 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 839 | 21 | 9 | 9 | 3.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccccc1O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
| CHEMBL3144538 | 106855 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 839 | 21 | 9 | 9 | 3.0 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccccc1O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
| 44280224 | 104840 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 757 | 16 | 4 | 7 | 5.8 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL31090 | 104840 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 757 | 16 | 4 | 7 | 5.8 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL3142682 | 213586 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)NC1CCCCC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||||
| 14991574 | 100757 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 836 | 20 | 9 | 8 | 3.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
| CHEMBL292471 | 100757 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 836 | 20 | 9 | 8 | 3.3 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
| 90663992 | 106877 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 866 | 22 | 8 | 9 | 3.3 | CN(C)c1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm00089a010 | |||
| CHEMBL3144561 | 106877 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 866 | 22 | 8 | 9 | 3.3 | CN(C)c1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 | 10.1021/jm00089a010 | |||
| 44280130 | 161373 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 670 | 11 | 3 | 5 | 5.0 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCc2ccccc21 | 10.1021/jm950372w | |||
| CHEMBL412108 | 161373 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 670 | 11 | 3 | 5 | 5.0 | O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCc2ccccc21 | 10.1021/jm950372w | |||
| 11797585 | 98509 | None | 0 | Mouse | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 445 | 6 | 3 | 7 | 3.9 | COc1ccc(-n2c(NNC(=O)Nc3cccc(C)c3)nc3ccccc3c2=O)cc1OC | 10.1021/jm970373j | |||
| CHEMBL275789 | 98509 | None | 0 | Mouse | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 445 | 6 | 3 | 7 | 3.9 | COc1ccc(-n2c(NNC(=O)Nc3cccc(C)c3)nc3ccccc3c2=O)cc1OC | 10.1021/jm970373j | |||
| 10322621 | 57575 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 473 | 7 | 2 | 7 | 4.4 | CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc([N+](=O)[O-])cc3)nc3ccccc3c2=O)c1 | 10.1016/S0960-894X(97)00108-X | |||
| CHEMBL166443 | 57575 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 473 | 7 | 2 | 7 | 4.4 | CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc([N+](=O)[O-])cc3)nc3ccccc3c2=O)c1 | 10.1016/S0960-894X(97)00108-X | |||
| 44280398 | 99299 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 601 | 10 | 2 | 4 | 5.2 | CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(Cc1ccccc1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL281728 | 99299 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 601 | 10 | 2 | 4 | 5.2 | CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(Cc1ccccc1)C(=O)O | 10.1021/jm950372w | |||
| 44280101 | 99647 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 573 | 9 | 3 | 4 | 5.3 | O=C(O)Cc1cccc(NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)c1 | 10.1021/jm950372w | |||
| CHEMBL283920 | 99647 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 573 | 9 | 3 | 4 | 5.3 | O=C(O)Cc1cccc(NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)c1 | 10.1021/jm950372w | |||
| 40652201 | 201547 | None | 0 | Mouse | Binding | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 407 | 9 | 3 | 3 | 4.2 | CC(C)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 | 10.1016/S0960-894X(97)00346-6 | |||
| CHEMBL58852 | 201547 | None | 0 | Mouse | Binding | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 407 | 9 | 3 | 3 | 4.2 | CC(C)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 | 10.1016/S0960-894X(97)00346-6 | |||
| 10530757 | 118627 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 553 | 10 | 3 | 7 | 3.6 | COC(=O)CC(CC(=O)OC)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1021/jm970065l | |||
| CHEMBL341560 | 118627 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 553 | 10 | 3 | 7 | 3.6 | COC(=O)CC(CC(=O)OC)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1021/jm970065l | |||
| 44280178 | 102677 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 601 | 11 | 3 | 4 | 5.3 | O=C(O)C[C@@H](Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL30422 | 102677 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 601 | 11 | 3 | 4 | 5.3 | O=C(O)C[C@@H](Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 44280131 | 99646 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 680 | 11 | 4 | 5 | 5.8 | O=C(O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 | 10.1021/jm950372w | |||
| CHEMBL283914 | 99646 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 680 | 11 | 4 | 5 | 5.8 | O=C(O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 | 10.1021/jm950372w | |||
| 44280214 | 107358 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 770 | 16 | 6 | 10 | 3.6 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL31726 | 107358 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 770 | 16 | 6 | 10 | 3.6 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| 44280225 | 100017 | None | 0 | Mouse | Binding | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 743 | 15 | 4 | 7 | 5.4 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL286475 | 100017 | None | 0 | Mouse | Binding | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 743 | 15 | 4 | 7 | 5.4 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| 44349240 | 118181 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 368 | 11 | 3 | 3 | 3.0 | CCCCCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 | 10.1021/jm00079a003 | |||
| CHEMBL340755 | 118181 | None | 0 | Rat | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 368 | 11 | 3 | 3 | 3.0 | CCCCCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 | 10.1021/jm00079a003 | |||
| 44280123 | 99327 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 626 | 10 | 4 | 4 | 5.3 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL281903 | 99327 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 626 | 10 | 4 | 4 | 5.3 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1021/jm950372w | |||
| 44303488 | 101113 | None | 0 | Mouse | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 501 | 8 | 2 | 6 | 4.1 | CC(Cn1nnc2ccccc21)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
| CHEMBL294735 | 101113 | None | 0 | Mouse | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 501 | 8 | 2 | 6 | 4.1 | CC(Cn1nnc2ccccc21)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
| 10077166 | 99988 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | 75 | 2 | ChEMBL | 591 | 10 | 3 | 4 | 5.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O | 10.1016/s0960-894x(98)00231-5 | |||
| CHEMBL286247 | 99988 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | 75 | 2 | ChEMBL | 591 | 10 | 3 | 4 | 5.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O | 10.1016/s0960-894x(98)00231-5 | |||
| 44280157 | 155819 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | 75 | 2 | ChEMBL | 667 | 8 | 3 | 5 | 6.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@H]1C(=O)O | 10.1016/s0960-894x(98)00231-5 | |||
| CHEMBL405468 | 155819 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | 75 | 2 | ChEMBL | 667 | 8 | 3 | 5 | 6.9 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@H]1C(=O)O | 10.1016/s0960-894x(98)00231-5 | |||
| CHEMBL205306 | 211627 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | -109 | 3 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | |||||
| 10668688 | 209991 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 400 | 4 | 4 | 6 | 3.4 | Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(N)c2)c1 | 10.1021/jm970373j | |||
| CHEMBL9465 | 209991 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 400 | 4 | 4 | 6 | 3.4 | Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(N)c2)c1 | 10.1021/jm970373j | |||
| 44280102 | 102764 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 587 | 10 | 3 | 4 | 4.9 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccccc1)C(=O)O | 10.1021/jm950372w | |||
| CHEMBL30481 | 102764 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 587 | 10 | 3 | 4 | 4.9 | O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccccc1)C(=O)O | 10.1021/jm950372w | |||
| 44387108 | 168357 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 650 | 9 | 3 | 5 | 4.7 | COC(=O)[C@@]1(Cc2ccccc2)C[C@H]2[C@H](NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)C34CC5CC(CC(C5)C3)C4)CCCN2C1=O | 10.1016/0960-894X(96)00160-6 | |||
| CHEMBL433770 | 168357 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 650 | 9 | 3 | 5 | 4.7 | COC(=O)[C@@]1(Cc2ccccc2)C[C@H]2[C@H](NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)C34CC5CC(CC(C5)C3)C4)CCCN2C1=O | 10.1016/0960-894X(96)00160-6 | |||
| 10504136 | 209096 | None | 0 | Mouse | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 459 | 7 | 3 | 7 | 4.3 | COc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 | 10.1021/jm970373j | |||
| CHEMBL8922 | 209096 | None | 0 | Mouse | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 459 | 7 | 3 | 7 | 4.3 | COc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 | 10.1021/jm970373j | |||
| 10791546 | 209541 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 501 | 8 | 3 | 8 | 4.5 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 | 10.1021/jm970373j | |||
| CHEMBL9188 | 209541 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 501 | 8 | 3 | 8 | 4.5 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 | 10.1021/jm970373j | |||
| CHEMBL438911 | 216267 | None | 0 | Bovine | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00100a033 | |||||
| 10070677 | 161818 | None | 15 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00121a004 | |||
| CHEMBL41361 | 161818 | None | 15 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00121a004 | |||
| 14888736 | 98139 | None | 0 | Bovine | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 974 | 29 | 10 | 11 | 1.2 | CSCC[C@H](NC(=O)CCc1ccc(CC(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
| CHEMBL273344 | 98139 | None | 0 | Bovine | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 974 | 29 | 10 | 11 | 1.2 | CSCC[C@H](NC(=O)CCc1ccc(CC(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00107a037 | |||
| 44356868 | 25984 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 412 | 3 | 2 | 3 | 4.3 | Cc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1C | 10.1021/jm00078a018 | |||
| CHEMBL135433 | 25984 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 412 | 3 | 2 | 3 | 4.3 | Cc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1C | 10.1021/jm00078a018 | |||
| 10346957 | 26961 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 531 | 7 | 2 | 4 | 4.9 | CCN(CC)C(=O)C(C)N1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| CHEMBL136436 | 26961 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 531 | 7 | 2 | 4 | 4.9 | CCN(CC)C(=O)C(C)N1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| 44356801 | 165606 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 408 | 3 | 2 | 3 | 3.6 | C#Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
| CHEMBL424076 | 165606 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 408 | 3 | 2 | 3 | 3.6 | C#Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
| 44386486 | 130758 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 650 | 9 | 3 | 5 | 4.7 | COC(=O)[C@]1(Cc2ccccc2)C[C@@H]2[C@@H](NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)C34CC5CC(CC(C5)C3)C4)CCCN2C1=O | 10.1016/0960-894X(96)00160-6 | |||
| CHEMBL368356 | 130758 | None | 0 | Rat | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 650 | 9 | 3 | 5 | 4.7 | COC(=O)[C@]1(Cc2ccccc2)C[C@@H]2[C@@H](NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)C34CC5CC(CC(C5)C3)C4)CCCN2C1=O | 10.1016/0960-894X(96)00160-6 | |||
| 10253366 | 116409 | None | 13 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 452 | 3 | 2 | 3 | 5.0 | CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2Cl)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| CHEMBL335951 | 116409 | None | 13 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 452 | 3 | 2 | 3 | 5.0 | CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2Cl)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| 44281004 | 100133 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 773 | 15 | 4 | 8 | 6.4 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3cccc(OC(=O)NCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00249-1 | |||
| CHEMBL287295 | 100133 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 773 | 15 | 4 | 8 | 6.4 | Cc1cccc(NC(=O)N[C@@H]2N=C(c3cccc(OC(=O)NCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00249-1 | |||
| 19766168 | 59576 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 367 | 4 | 3 | 3 | 2.5 | Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)O)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
| CHEMBL171722 | 59576 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 367 | 4 | 3 | 3 | 2.5 | Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)O)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
| 10474221 | 16856 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 368 | 8 | 3 | 3 | 2.9 | CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 | 10.1021/jm00079a003 | |||
| CHEMBL124822 | 16856 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 368 | 8 | 3 | 3 | 2.9 | CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 | 10.1021/jm00079a003 | |||
| 44381489 | 97246 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 1124 | 30 | 10 | 12 | 4.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80679-4 | |||
| CHEMBL268337 | 97246 | None | 0 | Rat | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 1124 | 30 | 10 | 12 | 4.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(00)80679-4 | |||
| 44382735 | 120827 | None | 0 | Mouse | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 646 | 13 | 4 | 4 | 6.1 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCc1ccccc1 | 10.1016/S0960-894X(00)80687-3 | |||
| CHEMBL355275 | 120827 | None | 0 | Mouse | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 646 | 13 | 4 | 4 | 6.1 | O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCc1ccccc1 | 10.1016/S0960-894X(00)80687-3 | |||
| 14208267 | 206984 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 380 | 3 | 2 | 4 | 3.1 | N#Cc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 | 10.1021/jm00120a002 | |||
| CHEMBL72710 | 206984 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 380 | 3 | 2 | 4 | 3.1 | N#Cc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 | 10.1021/jm00120a002 | |||
| 11062139 | 96730 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 703 | 8 | 5 | 6 | 5.5 | O=C(O)c1cc(NC(=O)C2Cc3ccccc3CCCN2C(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1016/S0960-894X(97)00211-4 | |||
| CHEMBL26390 | 96730 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 703 | 8 | 5 | 6 | 5.5 | O=C(O)c1cc(NC(=O)C2Cc3ccccc3CCCN2C(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1016/S0960-894X(97)00211-4 | |||
| 11765552 | 113694 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 742 | 17 | 7 | 6 | 5.8 | Cc1ccccc1NC(=O)NCCCC[C@@H](CNC(=O)CCC(=O)O)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1021/jm00017a022 | |||
| CHEMBL332263 | 113694 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 742 | 17 | 7 | 6 | 5.8 | Cc1ccccc1NC(=O)NCCCC[C@@H](CNC(=O)CCC(=O)O)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1021/jm00017a022 | |||
| 10740785 | 97364 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 419 | 4 | 3 | 5 | 4.5 | Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(Cl)c2)c1 | 10.1021/jm970373j | |||
| CHEMBL269142 | 97364 | None | 0 | Mouse | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 419 | 4 | 3 | 5 | 4.5 | Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(Cl)c2)c1 | 10.1021/jm970373j | |||
| 44286379 | 100365 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 852 | 21 | 6 | 9 | 3.3 | CN(C(=O)[C@H](CCCCNC(=O)/C=C/c1cccnc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00037a006 | |||
| CHEMBL289284 | 100365 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 852 | 21 | 6 | 9 | 3.3 | CN(C(=O)[C@H](CCCCNC(=O)/C=C/c1cccnc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00037a006 | |||
| 44303470 | 205723 | None | 0 | Mouse | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 479 | 8 | 2 | 5 | 4.5 | Cc1noc(C)c1CC(C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
| CHEMBL64623 | 205723 | None | 0 | Mouse | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 479 | 8 | 2 | 5 | 4.5 | Cc1noc(C)c1CC(C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 | 10.1016/S0960-894X(97)00356-9 | |||
| 15670985 | 209549 | None | 0 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 490 | 9 | 3 | 5 | 3.2 | COc1cccc(N(CC(=O)N(C)c2ccccc2)C(=O)CNC(=O)Nc2cccc(C(=O)O)c2)c1 | 10.1021/jm970373j | |||
| CHEMBL9195 | 209549 | None | 0 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 490 | 9 | 3 | 5 | 3.2 | COc1cccc(N(CC(=O)N(C)c2ccccc2)C(=O)CNC(=O)Nc2cccc(C(=O)O)c2)c1 | 10.1021/jm970373j | |||
| 10070677 | 161818 | None | 15 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00121a004 | |||
| CHEMBL41361 | 161818 | None | 15 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 418 | 3 | 2 | 3 | 4.3 | CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00121a004 | |||
| 73354293 | 106612 | None | 0 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 650 | 12 | 6 | 5 | 4.6 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCP(=O)(O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
| CHEMBL314178 | 106612 | None | 0 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 650 | 12 | 6 | 5 | 4.6 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCP(=O)(O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
| 73351319 | 168267 | None | 0 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 648 | 12 | 5 | 5 | 5.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCP(C)(=O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
| CHEMBL433148 | 168267 | None | 0 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 648 | 12 | 5 | 5 | 5.3 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCP(C)(=O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
| 44354100 | 116833 | None | 0 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 628 | 13 | 5 | 5 | 4.7 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1021/jm00105a062 | |||
| CHEMBL337661 | 116833 | None | 0 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 628 | 13 | 5 | 5 | 4.7 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1021/jm00105a062 | |||
| 73346732 | 170024 | None | 0 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 1017 | 29 | 9 | 10 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| CHEMBL444113 | 170024 | None | 0 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 1017 | 29 | 9 | 10 | 5.4 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| 44354100 | 120875 | None | 0 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 628 | 13 | 5 | 5 | 4.7 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
| CHEMBL355656 | 120875 | None | 0 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 628 | 13 | 5 | 5 | 4.7 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
| 44368567 | 168838 | None | 0 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 495 | 9 | 4 | 4 | 4.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1F)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL437039 | 168838 | None | 0 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 495 | 9 | 4 | 4 | 4.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1F)C(=O)N[C@H](CO)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| 44280740 | 100461 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 787 | 17 | 4 | 8 | 6.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
| CHEMBL290122 | 100461 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 787 | 17 | 4 | 8 | 6.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
| 15673154 | 86029 | None | 0 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 650 | 12 | 6 | 5 | 4.6 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCP(=O)(O)O)c1ccccc1 | 10.1016/S0960-894X(00)80652-6 | |||
| CHEMBL2304155 | 86029 | None | 0 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 650 | 12 | 6 | 5 | 4.6 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCP(=O)(O)O)c1ccccc1 | 10.1016/S0960-894X(00)80652-6 | |||
| 44376132 | 120310 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 494 | 6 | 3 | 6 | 3.9 | CC(C)CN1C(=O)[C@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00032a003 | |||
| CHEMBL352264 | 120310 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 494 | 6 | 3 | 6 | 3.9 | CC(C)CN1C(=O)[C@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00032a003 | |||
| 10507109 | 109283 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 561 | 7 | 2 | 4 | 5.3 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm960205b | |||
| CHEMBL321761 | 109283 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 561 | 7 | 2 | 4 | 5.3 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm960205b | |||
| 14843044 | 99703 | None | 0 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 511 | 4 | 1 | 3 | 6.4 | O=c1c2ccccc2nc(CCc2c[nH]c3ccc(Br)cc23)n1-c1cccc(C(F)(F)F)c1 | 10.1021/jm00108a040 | |||
| CHEMBL284317 | 99703 | None | 0 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 511 | 4 | 1 | 3 | 6.4 | O=c1c2ccccc2nc(CCc2c[nH]c3ccc(Br)cc23)n1-c1cccc(C(F)(F)F)c1 | 10.1021/jm00108a040 | |||
| 44280116 | 99686 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 672 | 12 | 3 | 6 | 5.8 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL284183 | 99686 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 672 | 12 | 3 | 6 | 5.8 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
| 44334354 | 4623 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 517 | 9 | 2 | 4 | 5.0 | Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCC(C(=O)c3ccc(F)cc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
| CHEMBL102879 | 4623 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 517 | 9 | 2 | 4 | 5.0 | Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCC(C(=O)c3ccc(F)cc3)CC2)c1 | 10.1016/0960-894X(95)00537-3 | |||
| 10252890 | 25631 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 444 | 5 | 2 | 5 | 3.7 | COc1cc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc(OC)c1 | 10.1021/jm00078a018 | |||
| CHEMBL135167 | 25631 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 444 | 5 | 2 | 5 | 3.7 | COc1cc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc(OC)c1 | 10.1021/jm00078a018 | |||
| 44349023 | 16361 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 384 | 8 | 3 | 3 | 3.4 | CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1ccc2ccccc2c1 | 10.1021/jm00079a003 | |||
| CHEMBL122922 | 16361 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 384 | 8 | 3 | 3 | 3.4 | CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1ccc2ccccc2c1 | 10.1021/jm00079a003 | |||
| 44349027 | 16833 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 438 | 7 | 3 | 5 | 2.9 | O=C(O)CCC(NC(=O)c1cnc2ccccc2c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
| CHEMBL124732 | 16833 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 438 | 7 | 3 | 5 | 2.9 | O=C(O)CCC(NC(=O)c1cnc2ccccc2c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
| 44349429 | 16844 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 406 | 7 | 3 | 4 | 3.0 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)C1CC2CCCCC2CN1 | 10.1021/jm00079a003 | |||
| CHEMBL124780 | 16844 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 406 | 7 | 3 | 4 | 3.0 | O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)C1CC2CCCCC2CN1 | 10.1021/jm00079a003 | |||
| 71456173 | 78515 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 455 | 7 | 3 | 4 | 3.6 | O=C(O)CC[C@H](NC(=O)c1ccc(Cl)c(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
| CHEMBL2111826 | 78515 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 455 | 7 | 3 | 4 | 3.6 | O=C(O)CC[C@H](NC(=O)c1ccc(Cl)c(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 | 10.1021/jm00079a003 | |||
| 10531 | 1420 | None | 13 | Mouse | Binding | pIC50 | = | 4.6 | 4.6 | - | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/S0960-894X(00)80644-7 | |||
| 10531.0 | 1420 | None | 13 | Mouse | Binding | pIC50 | = | 4.6 | 4.6 | - | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/S0960-894X(00)80644-7 | |||
| 121 | 1420 | None | 13 | Mouse | Binding | pIC50 | = | 4.6 | 4.6 | - | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/S0960-894X(00)80644-7 | |||
| 888 | 1420 | None | 13 | Mouse | Binding | pIC50 | = | 4.6 | 4.6 | - | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/S0960-894X(00)80644-7 | |||
| CHEMBL1732 | 1420 | None | 13 | Mouse | Binding | pIC50 | = | 4.6 | 4.6 | - | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/S0960-894X(00)80644-7 | |||
| DB00320 | 1420 | None | 13 | Mouse | Binding | pIC50 | = | 4.6 | 4.6 | - | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.1016/S0960-894X(00)80644-7 | |||
| 44348808 | 17942 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 451 | 7 | 3 | 4 | 3.9 | O=C(O)CCC(NC(=O)c1ccc2ccccc2c1)C(=O)NN1CCC2(CCCCC2)CC1 | 10.1021/jm00079a003 | |||
| CHEMBL125925 | 17942 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 451 | 7 | 3 | 4 | 3.9 | O=C(O)CCC(NC(=O)c1ccc2ccccc2c1)C(=O)NN1CCC2(CCCCC2)CC1 | 10.1021/jm00079a003 | |||
| 44360340 | 32712 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 457 | 5 | 1 | 4 | 5.1 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)Cc1cccc2sccc12 | 10.1021/jm00163a069 | |||
| CHEMBL141354 | 32712 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 457 | 5 | 1 | 4 | 5.1 | CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)Cc1cccc2sccc12 | 10.1021/jm00163a069 | |||
| CHEMBL411079 | 215322 | None | 0 | Bovine | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N1CSC(C)(C)[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00100a033 | |||||
| 44396732 | 66914 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 545 | 7 | 2 | 6 | 4.5 | CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC(C)(C)C)CCCN3C2=O)cc1 | 10.1021/jm0498755 | |||
| CHEMBL186438 | 66914 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 545 | 7 | 2 | 6 | 4.5 | CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC(C)(C)C)CCCN3C2=O)cc1 | 10.1021/jm0498755 | |||
| 10962743 | 78628 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 559 | 6 | 3 | 5 | 4.4 | Cc1ccc(N2C(=O)C[C@@H]3[C@@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)cc1 | 10.1021/jm010813d | |||
| CHEMBL2112239 | 78628 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 559 | 6 | 3 | 5 | 4.4 | Cc1ccc(N2C(=O)C[C@@H]3[C@@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)cc1 | 10.1021/jm010813d | |||
| 11028319 | 79688 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 588 | 7 | 3 | 6 | 4.2 | CN(C)c1ccc(N2C(=O)C[C@@H]3[C@@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)cc1 | 10.1021/jm010813d | |||
| CHEMBL2115130 | 79688 | None | 0 | Rat | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 588 | 7 | 3 | 6 | 4.2 | CN(C)c1ccc(N2C(=O)C[C@@H]3[C@@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)cc1 | 10.1021/jm010813d | |||
| 10078362 | 99845 | None | 0 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 689 | 8 | 5 | 6 | 5.2 | O=C(O)c1cc(NC(=O)C2Cc3ccccc3CCN2C(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1016/S0960-894X(97)00211-4 | |||
| CHEMBL285305 | 99845 | None | 0 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 689 | 8 | 5 | 6 | 5.2 | O=C(O)c1cc(NC(=O)C2Cc3ccccc3CCN2C(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 | 10.1016/S0960-894X(97)00211-4 | |||
| 90663996 | 106881 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 919 | 23 | 9 | 11 | 2.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1cccc(OS(=O)(=O)O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
| CHEMBL3144565 | 106881 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 919 | 23 | 9 | 11 | 2.4 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1cccc(OS(=O)(=O)O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||
| 10555571 | 104633 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 601 | 8 | 0 | 6 | 5.9 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(C)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm960249k | |||
| CHEMBL310466 | 104633 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 601 | 8 | 0 | 6 | 5.9 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(C)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm960249k | |||
| 10555571 | 104633 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 601 | 8 | 0 | 6 | 5.9 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(C)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
| CHEMBL310466 | 104633 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 601 | 8 | 0 | 6 | 5.9 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(C)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
| 15667015 | 161948 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 990 | 29 | 10 | 11 | 2.0 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
| CHEMBL414793 | 161948 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 990 | 29 | 10 | 11 | 2.0 | CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00094a001 | |||
| 9985099 | 117342 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 552 | 5 | 3 | 3 | 6.0 | CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2cc(Cl)ccc21 | 10.1021/jm00048a015 | |||
| CHEMBL339515 | 117342 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 552 | 5 | 3 | 3 | 6.0 | CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2cc(Cl)ccc21 | 10.1021/jm00048a015 | |||
| 14208226 | 77857 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 426 | 3 | 2 | 3 | 3.9 | CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| CHEMBL2092871 | 77857 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 426 | 3 | 2 | 3 | 3.9 | CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| 44280029 | 96494 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 740 | 15 | 6 | 9 | 3.5 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL262125 | 96494 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 740 | 15 | 6 | 9 | 3.5 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
| 44381550 | 165328 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 842 | 23 | 11 | 10 | 3.0 | Cc1ccccc1NC(=O)NCCCC[C@@H](CNN[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1016/S0960-894X(00)80680-0 | |||
| CHEMBL422919 | 165328 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 842 | 23 | 11 | 10 | 3.0 | Cc1ccccc1NC(=O)NCCCC[C@@H](CNN[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1016/S0960-894X(00)80680-0 | |||
| 13822921 | 101683 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 431 | 3 | 1 | 5 | 4.3 | O=C(NC1N=C(c2ccccc2F)c2ccccc2-n2cnnc21)c1ccc(Cl)cc1 | 10.1021/jm00396a028 | |||
| CHEMBL298948 | 101683 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 431 | 3 | 1 | 5 | 4.3 | O=C(NC1N=C(c2ccccc2F)c2ccccc2-n2cnnc21)c1ccc(Cl)cc1 | 10.1021/jm00396a028 | |||
| 14208275 | 67768 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 443 | 3 | 1 | 3 | 4.7 | CN1C(=O)[C@@H](NC(=O)c2ccc(C(C)(C)C)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| CHEMBL1907849 | 67768 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 443 | 3 | 1 | 3 | 4.7 | CN1C(=O)[C@@H](NC(=O)c2ccc(C(C)(C)C)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| 14208270 | 67773 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 447 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@H](NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
| CHEMBL1907853 | 67773 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 447 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@H](NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
| 15167812 | 102251 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 437 | 3 | 1 | 3 | 3.6 | CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)[N+]([O-])=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| CHEMBL302825 | 102251 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 437 | 3 | 1 | 3 | 3.6 | CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)[N+]([O-])=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00120a002 | |||
| 10078285 | 121571 | None | 0 | Mouse | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 680 | 12 | 3 | 6 | 5.7 | C[Si](C)(C)CCOC(=O)C[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1016/s0960-894x(98)00677-5 | |||
| CHEMBL358334 | 121571 | None | 0 | Mouse | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 680 | 12 | 3 | 6 | 5.7 | C[Si](C)(C)CCOC(=O)C[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 | 10.1016/s0960-894x(98)00677-5 | |||
| 44375064 | 52953 | None | 0 | Mouse | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 554 | 10 | 6 | 7 | 4.0 | O=C(O)c1ccc(N/C(S)=N\Nc2ccc(S(=O)(=O)NCCc3c[nH]c4ccccc34)cc2[N+](=O)[O-])cc1 | 10.1016/s0960-894x(01)00044-0 | |||
| CHEMBL159623 | 52953 | None | 0 | Mouse | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 554 | 10 | 6 | 7 | 4.0 | O=C(O)c1ccc(N/C(S)=N\Nc2ccc(S(=O)(=O)NCCc3c[nH]c4ccccc34)cc2[N+](=O)[O-])cc1 | 10.1016/s0960-894x(01)00044-0 | |||
| 44375437 | 120131 | None | 0 | Mouse | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 506 | 11 | 6 | 7 | 2.3 | O=C(O)CCNS(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 | 10.1016/s0960-894x(01)00044-0 | |||
| CHEMBL350631 | 120131 | None | 0 | Mouse | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 506 | 11 | 6 | 7 | 2.3 | O=C(O)CCNS(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 | 10.1016/s0960-894x(01)00044-0 | |||
| 44375447 | 165445 | None | 0 | Mouse | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 610 | 14 | 5 | 7 | 4.6 | O=C(O)CCCN(Cc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 | 10.1016/s0960-894x(01)00044-0 | |||
| CHEMBL423630 | 165445 | None | 0 | Mouse | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 610 | 14 | 5 | 7 | 4.6 | O=C(O)CCCN(Cc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 | 10.1016/s0960-894x(01)00044-0 | |||
| 443375 | 210065 | None | 33 | Human | Binding | pIC50 | = | 6.6 | 6.6 | -316 | 5 | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80683-6 | |||
| CHEMBL9506 | 210065 | None | 33 | Human | Binding | pIC50 | = | 6.6 | 6.6 | -316 | 5 | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80683-6 | |||
| 443375 | 210065 | None | 33 | Human | Binding | pIC50 | = | 6.6 | 6.6 | -316 | 5 | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00121a004 | |||
| CHEMBL9506 | 210065 | None | 33 | Human | Binding | pIC50 | = | 6.6 | 6.6 | -316 | 5 | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00121a004 | |||
| 443375 | 210065 | None | 33 | Human | Binding | pIC50 | = | 6.6 | 6.6 | -316 | 5 | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm020424z | |||
| CHEMBL9506 | 210065 | None | 33 | Human | Binding | pIC50 | = | 6.6 | 6.6 | -316 | 5 | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm020424z | |||
| 443375 | 210065 | None | 33 | Human | Binding | pIC50 | = | 6.6 | 6.6 | -316 | 5 | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00609-9 | |||
| CHEMBL9506 | 210065 | None | 33 | Human | Binding | pIC50 | = | 6.6 | 6.6 | -316 | 5 | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00609-9 | |||
| 443375 | 210065 | None | 33 | Human | Binding | pIC50 | = | 6.6 | 6.6 | -316 | 5 | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00163a069 | |||
| CHEMBL9506 | 210065 | None | 33 | Human | Binding | pIC50 | = | 6.6 | 6.6 | -316 | 5 | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00163a069 | |||
| 155535579 | 172153 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 1836 | 71 | 17 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| CHEMBL4471871 | 172153 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 1836 | 71 | 17 | 23 | 2.9 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01558 | |||
| 10790099 | 209732 | None | 0 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 459 | 7 | 3 | 7 | 4.3 | COc1ccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)cc1 | 10.1021/jm970373j | |||
| CHEMBL9311 | 209732 | None | 0 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 459 | 7 | 3 | 7 | 4.3 | COc1ccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)cc1 | 10.1021/jm970373j | |||
| CHEMBL3143668 | 213638 | None | 0 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/0960-894X(96)00160-6 | |||||
| CHEMBL64605 | 218346 | None | 5 | Human | Binding | pIC50 | = | 7.6 | 7.6 | -4 | 3 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00105a068 | |||||
| CHEMBL64605 | 218346 | None | 5 | Human | Binding | pIC50 | = | 7.6 | 7.6 | -4 | 3 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00173a006 | |||||
| CHEMBL64605 | 218346 | None | 5 | Human | Binding | pIC50 | = | 7.6 | 7.6 | -4 | 3 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80680-0 | |||||
| CHEMBL64605 | 218346 | None | 5 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | 4 | 3 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050689o | |||||
| CHEMBL64605 | 218346 | None | 5 | Human | Binding | pIC50 | = | 7.6 | 7.6 | -4 | 3 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00089a010 | |||||
| 90663193 | 106667 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 739 | 17 | 8 | 9 | 1.7 | CSCC[C@H](NC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm960509y | |||
| CHEMBL3142902 | 106667 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 739 | 17 | 8 | 9 | 1.7 | CSCC[C@H](NC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C | 10.1021/jm960509y | |||
| 44329055 | 210423 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 554 | 7 | 3 | 3 | 6.1 | CCc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(C)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 | 10.1016/S0960-894X(01)80832-5 | |||
| CHEMBL97133 | 210423 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 554 | 7 | 3 | 3 | 6.1 | CCc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(C)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 | 10.1016/S0960-894X(01)80832-5 | |||
| 44280215 | 99884 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 756 | 15 | 6 | 10 | 3.3 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL285586 | 99884 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 756 | 15 | 6 | 10 | 3.3 | Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL64605 | 218346 | None | 5 | Human | Binding | pIC50 | = | 7.6 | 7.6 | -4 | 3 | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(97)00107-8 | |||||
| 10507109 | 109283 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 561 | 7 | 2 | 4 | 5.3 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm9601664 | |||
| CHEMBL321761 | 109283 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 561 | 7 | 2 | 4 | 5.3 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm9601664 | |||
| 10507109 | 109283 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 561 | 7 | 2 | 4 | 5.3 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm950626d | |||
| CHEMBL321761 | 109283 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 561 | 7 | 2 | 4 | 5.3 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm950626d | |||
| 10626596 | 112844 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 555 | 7 | 1 | 4 | 5.6 | O=C1C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc2N1CC(=O)N(c1ccccc1)C1CC1 | 10.1021/jm970265x | |||
| CHEMBL330566 | 112844 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 555 | 7 | 1 | 4 | 5.6 | O=C1C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc2N1CC(=O)N(c1ccccc1)C1CC1 | 10.1021/jm970265x | |||
| 10507109 | 109283 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 561 | 7 | 2 | 4 | 5.3 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/S0960-894X(97)00062-0 | |||
| CHEMBL321761 | 109283 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 561 | 7 | 2 | 4 | 5.3 | CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1016/S0960-894X(97)00062-0 | |||
| 155519400 | 170537 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 1409 | 38 | 15 | 21 | -2.1 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)n1cc([C@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1 | 10.1021/acs.jmedchem.9b01936 | |||
| CHEMBL4448553 | 170537 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 1409 | 38 | 15 | 21 | -2.1 | CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)n1cc([C@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1 | 10.1021/acs.jmedchem.9b01936 | |||
| 10649296 | 30784 | None | 0 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 507 | 6 | 4 | 4 | 4.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H]1CCCCC[C@@H]1O | 10.1021/jm970065l | |||
| CHEMBL139601 | 30784 | None | 0 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 507 | 6 | 4 | 4 | 4.8 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H]1CCCCC[C@@H]1O | 10.1021/jm970065l | |||
| CHEMBL382051 | 214753 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | -131 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | |||||
| 10325426 | 107657 | None | 0 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 557 | 10 | 3 | 4 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O | 10.1016/S0960-894X(01)80769-1 | |||
| CHEMBL318963 | 107657 | None | 0 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 557 | 10 | 3 | 4 | 5.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O | 10.1016/S0960-894X(01)80769-1 | |||
| 155516160 | 170161 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 1399 | 39 | 16 | 19 | -2.7 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)C[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.9b01936 | |||
| CHEMBL4443016 | 170161 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 1399 | 39 | 16 | 19 | -2.7 | CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)C[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.9b01936 | |||
| 73351327 | 82457 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 1019 | 29 | 9 | 11 | 4.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| CHEMBL217424 | 82457 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 1019 | 29 | 9 | 11 | 4.9 | CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O | 10.1021/jm00072a024 | |||
| 10073533 | 22562 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 472 | 7 | 3 | 5 | 3.5 | COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCC(=O)O)C2=O)c1 | 10.1021/jm00078a018 | |||
| CHEMBL132603 | 22562 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 472 | 7 | 3 | 5 | 3.5 | COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCC(=O)O)C2=O)c1 | 10.1021/jm00078a018 | |||
| 44376191 | 165420 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 452 | 4 | 3 | 6 | 2.8 | CN1C(=O)[C@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00032a003 | |||
| CHEMBL423472 | 165420 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 452 | 4 | 3 | 6 | 2.8 | CN1C(=O)[C@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00032a003 | |||
| 19766168 | 59576 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 367 | 4 | 3 | 3 | 2.5 | Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)O)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
| CHEMBL171722 | 59576 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 367 | 4 | 3 | 3 | 2.5 | Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)O)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
| CHEMBL290444 | 213336 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | None | None | None | CCS[C@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00001a019 | |||||
| 44382487 | 165731 | None | 0 | Mouse | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 518 | 10 | 4 | 4 | 2.7 | CC(C)C[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O | 10.1016/S0960-894X(01)80253-5 | |||
| CHEMBL424370 | 165731 | None | 0 | Mouse | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 518 | 10 | 4 | 4 | 2.7 | CC(C)C[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O | 10.1016/S0960-894X(01)80253-5 | |||
| 9988264 | 109779 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 888 | 22 | 9 | 8 | 3.5 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
| CHEMBL322955 | 109779 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 888 | 22 | 9 | 8 | 3.5 | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00028a015 | |||
| 14208241 | 67772 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 421 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00121a004 | |||
| CHEMBL1907852 | 67772 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 421 | 3 | 1 | 3 | 4.0 | CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 | 10.1021/jm00121a004 | |||
| 44381562 | 168717 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 827 | 22 | 10 | 9 | 3.5 | Cc1ccccc1NC(=O)NCCCC[C@H](NNC[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80680-0 | |||
| CHEMBL436053 | 168717 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 827 | 22 | 10 | 9 | 3.5 | Cc1ccccc1NC(=O)NCCCC[C@H](NNC[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/S0960-894X(00)80680-0 | |||
| CHEMBL328422 | 213755 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | None | None | None | Cc1cccc(C)c1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||||
| 3960 | 2345 | None | 18 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 10.1021/jm00079a003 | |||
| 891 | 2345 | None | 18 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 10.1021/jm00079a003 | |||
| CHEMBL24938 | 2345 | None | 18 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 458 | 14 | 2 | 3 | 5.2 | CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC | 10.1021/jm00079a003 | |||
| 13953692 | 101776 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 407 | 3 | 1 | 4 | 5.0 | Fc1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)c2nncn2-c2ccccc21 | 10.1021/jm00396a028 | |||
| CHEMBL299538 | 101776 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 407 | 3 | 1 | 4 | 5.0 | Fc1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)c2nncn2-c2ccccc21 | 10.1021/jm00396a028 | |||
| 14208220 | 206988 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 365 | 6 | 1 | 5 | 1.5 | CCOC(=O)CN1C(=O)C(NC=O)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
| CHEMBL72738 | 206988 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 365 | 6 | 1 | 5 | 1.5 | CCOC(=O)CN1C(=O)C(NC=O)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
| 14208213 | 207066 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 362 | 3 | 3 | 3 | 2.7 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc[nH]1 | 10.1021/jm00120a002 | |||
| CHEMBL73272 | 207066 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 362 | 3 | 3 | 3 | 2.7 | O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc[nH]1 | 10.1021/jm00120a002 | |||
| 5279119 | 207211 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 423 | 3 | 2 | 3 | 4.5 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00120a002 | |||
| CHEMBL74515 | 207211 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 423 | 3 | 2 | 3 | 4.5 | O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(Cl)c(Cl)c1 | 10.1021/jm00120a002 | |||
| 44366107 | 171822 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 649 | 16 | 6 | 6 | 3.8 | CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NCCc1ccccc1 | 10.1021/jm00123a003 | |||
| CHEMBL446693 | 171822 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 649 | 16 | 6 | 6 | 3.8 | CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NCCc1ccccc1 | 10.1021/jm00123a003 | |||
| 14154723 | 89554 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 636 | 14 | 7 | 6 | 3.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)NC(=O)NCc1ccccc1 | 10.1021/jm00388a002 | |||
| CHEMBL2373213 | 89554 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 636 | 14 | 7 | 6 | 3.6 | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)NC(=O)NCc1ccccc1 | 10.1021/jm00388a002 | |||
| 10348659 | 1804 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 604 | 8 | 2 | 5 | 5.4 | O=C(NC1C(=O)N(c2ccccc2)c2c(N(C1=O)CC(=O)N(c1ccc(cc1)N(C)C)C(C)C)cccc2)Nc1ccccc1 | 10.1021/jm950626d | |||
| 866 | 1804 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 604 | 8 | 2 | 5 | 5.4 | O=C(NC1C(=O)N(c2ccccc2)c2c(N(C1=O)CC(=O)N(c1ccc(cc1)N(C)C)C(C)C)cccc2)Nc1ccccc1 | 10.1021/jm950626d | |||
| CHEMBL1184355 | 1804 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 604 | 8 | 2 | 5 | 5.4 | O=C(NC1C(=O)N(c2ccccc2)c2c(N(C1=O)CC(=O)N(c1ccc(cc1)N(C)C)C(C)C)cccc2)Nc1ccccc1 | 10.1021/jm950626d | |||
| 10841358 | 209879 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 605 | 8 | 1 | 5 | 6.0 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccc(F)cc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
| CHEMBL94005 | 209879 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 605 | 8 | 1 | 5 | 6.0 | COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccc(F)cc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 | 10.1021/jm970265x | |||
| 44280233 | 99262 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 672 | 13 | 3 | 5 | 5.1 | CN(Cc1ccccc1)C(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL281490 | 99262 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 672 | 13 | 3 | 5 | 5.1 | CN(Cc1ccccc1)C(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 44280028 | 99231 | None | 0 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 768 | 17 | 6 | 9 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
| CHEMBL281318 | 99231 | None | 0 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 768 | 17 | 6 | 9 | 4.3 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00248-X | |||
| 44344743 | 163668 | None | 0 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 555 | 11 | 4 | 3 | 5.3 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)CC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 | 10.1021/jm000937a | |||
| CHEMBL420320 | 163668 | None | 0 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 555 | 11 | 4 | 3 | 5.3 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)CC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 | 10.1021/jm000937a | |||
| 904 | 3026 | None | 12 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
| 9915756 | 3026 | None | 12 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
| CHEMBL2111204 | 3026 | None | 12 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
| CHEMBL356898 | 3026 | None | 12 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/S0960-894X(00)80685-X | |||
| 904 | 3026 | None | 12 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/s0960-894x(98)00677-5 | |||
| 9915756 | 3026 | None | 12 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/s0960-894x(98)00677-5 | |||
| CHEMBL2111204 | 3026 | None | 12 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/s0960-894x(98)00677-5 | |||
| CHEMBL356898 | 3026 | None | 12 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1016/s0960-894x(98)00677-5 | |||
| 44210425 | 165389 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 439 | 5 | 2 | 5 | 3.5 | COc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
| CHEMBL423278 | 165389 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 439 | 5 | 2 | 5 | 3.5 | COc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
| 10623881 | 210056 | None | 0 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 461 | 6 | 3 | 7 | 3.9 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(F)c2)c1 | 10.1021/jm970373j | |||
| CHEMBL9501 | 210056 | None | 0 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 461 | 6 | 3 | 7 | 3.9 | CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(F)c2)c1 | 10.1021/jm970373j | |||
| 195737 | 123731 | None | 2 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 423 | 6 | 1 | 4 | 5.4 | CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 | 10.1021/jm00092a003 | |||
| CHEMBL36206 | 123731 | None | 2 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 423 | 6 | 1 | 4 | 5.4 | CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 | 10.1021/jm00092a003 | |||
| 195737 | 123731 | None | 2 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 423 | 6 | 1 | 4 | 5.4 | CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 | 10.1021/jm00108a040 | |||
| CHEMBL36206 | 123731 | None | 2 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 423 | 6 | 1 | 4 | 5.4 | CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 | 10.1021/jm00108a040 | |||
| 10252412 | 25780 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 435 | 3 | 2 | 4 | 4.2 | CN1C(=O)C(NC(=O)Nc2ccc3ccccc3n2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| CHEMBL135289 | 25780 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 435 | 3 | 2 | 4 | 4.2 | CN1C(=O)C(NC(=O)Nc2ccc3ccccc3n2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| 11753772 | 25999 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 455 | 6 | 2 | 4 | 3.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCN(C)C)C2=O)c1 | 10.1021/jm00078a018 | |||
| CHEMBL135447 | 25999 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 455 | 6 | 2 | 4 | 3.9 | Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCN(C)C)C2=O)c1 | 10.1021/jm00078a018 | |||
| 10047411 | 28613 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 414 | 4 | 2 | 4 | 3.7 | COc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 | 10.1021/jm00078a018 | |||
| CHEMBL137684 | 28613 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 414 | 4 | 2 | 4 | 3.7 | COc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 | 10.1021/jm00078a018 | |||
| 44356726 | 116846 | None | 9 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 428 | 3 | 2 | 5 | 3.4 | CN1C(=O)C(NC(=O)Nc2ccc3c(c2)OCO3)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| CHEMBL337733 | 116846 | None | 9 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 428 | 3 | 2 | 5 | 3.4 | CN1C(=O)C(NC(=O)Nc2ccc3c(c2)OCO3)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| 10767360 | 208303 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 489 | 5 | 2 | 4 | 5.2 | CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCC(C)(C)CCN2C)c2ccccc21 | 10.1021/jm9608523 | |||
| CHEMBL83591 | 208303 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 489 | 5 | 2 | 4 | 5.2 | CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCC(C)(C)CCN2C)c2ccccc21 | 10.1021/jm9608523 | |||
| 44281020 | 116708 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 773 | 16 | 4 | 8 | 6.2 | CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
| CHEMBL33698 | 116708 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 773 | 16 | 4 | 8 | 6.2 | CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
| 15282007 | 168411 | None | 0 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 472 | 5 | 3 | 5 | 3.7 | Cc1cccc(NC(=O)NC2N=C(c3c[nH]cn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
| CHEMBL434126 | 168411 | None | 0 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 472 | 5 | 3 | 5 | 3.7 | Cc1cccc(NC(=O)NC2N=C(c3c[nH]cn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 | 10.1016/0960-894X(95)00557-A | |||
| 5311205 | 13099 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(NC(=O)N[C@H]2N=C(N3CC4CCC(CC4)C3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
| CHEMBL1190319 | 13099 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(NC(=O)N[C@H]2N=C(N3CC4CCC(CC4)C3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
| CHEMBL540596 | 13099 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 445 | 2 | 2 | 4 | 4.0 | Cc1cccc(NC(=O)N[C@H]2N=C(N3CC4CCC(CC4)C3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00032a002 | |||
| 904 | 3026 | None | 12 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| 9915756 | 3026 | None | 12 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL2111204 | 3026 | None | 12 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL356898 | 3026 | None | 12 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 557 | 10 | 4 | 4 | 5.2 | OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 | 10.1021/jm00057a005 | |||
| CHEMBL3142692 | 213591 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | None | None | None | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc(Cl)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||||
| 15689727 | 106649 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 880 | 20 | 9 | 8 | 4.6 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc(Cl)cc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
| CHEMBL3142690 | 106649 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 880 | 20 | 9 | 8 | 4.6 | CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc(Cl)cc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm00113a023 | |||
| 44381925 | 12856 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 538 | 11 | 2 | 4 | 4.5 | CCN(CC)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
| CHEMBL1188615 | 12856 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 538 | 11 | 2 | 4 | 4.5 | CCN(CC)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
| CHEMBL536938 | 12856 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 538 | 11 | 2 | 4 | 4.5 | CCN(CC)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1016/S0960-894X(00)80681-2 | |||
| 13809511 | 102349 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 512 | 6 | 2 | 5 | 4.1 | CN1C(=O)C(NC(=O)[C@@H](Cc2ccccc2)NC(=O)OC(C)(C)C)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
| CHEMBL303386 | 102349 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 512 | 6 | 2 | 5 | 4.1 | CN1C(=O)C(NC(=O)[C@@H](Cc2ccccc2)NC(=O)OC(C)(C)C)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00120a002 | |||
| 10524785 | 210038 | None | 0 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 396 | 4 | 3 | 6 | 3.4 | N#Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccccc2)c1 | 10.1021/jm970373j | |||
| CHEMBL9492 | 210038 | None | 0 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 396 | 4 | 3 | 6 | 3.4 | N#Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccccc2)c1 | 10.1021/jm970373j | |||
| 44283081 | 99925 | None | 0 | Mouse | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 500 | 9 | 3 | 3 | 6.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(O)CCCc1ccccc1 | 10.1021/jm00086a017 | |||
| CHEMBL2112071 | 99925 | None | 0 | Mouse | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 500 | 9 | 3 | 3 | 6.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(O)CCCc1ccccc1 | 10.1021/jm00086a017 | |||
| CHEMBL285880 | 99925 | None | 0 | Mouse | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 500 | 9 | 3 | 3 | 6.4 | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(O)CCCc1ccccc1 | 10.1021/jm00086a017 | |||
| 10721792 | 167889 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 571 | 7 | 1 | 4 | 6.3 | CC(C)N(C(=O)CN1C(=O)C(C)(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm960249k | |||
| CHEMBL430451 | 167889 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 571 | 7 | 1 | 4 | 6.3 | CC(C)N(C(=O)CN1C(=O)C(C)(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 | 10.1021/jm960249k | |||
| 20063261 | 23133 | None | 14 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 412 | 3 | 2 | 3 | 4.3 | Cc1cc(C)cc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
| CHEMBL133087 | 23133 | None | 14 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 412 | 3 | 2 | 3 | 4.3 | Cc1cc(C)cc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 | 10.1021/jm00078a018 | |||
| 44280893 | 99290 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 652 | 13 | 4 | 5 | 5.0 | CC(C)(C)CCNC(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| CHEMBL281671 | 99290 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 652 | 13 | 4 | 5 | 5.0 | CC(C)(C)CCNC(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 | 10.1021/jm950372w | |||
| 10625001 | 29186 | None | 0 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 493 | 7 | 4 | 4 | 4.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1(CO)CCCC1 | 10.1021/jm970065l | |||
| CHEMBL138190 | 29186 | None | 0 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 493 | 7 | 4 | 4 | 4.4 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1(CO)CCCC1 | 10.1021/jm970065l | |||
| CHEMBL383458 | 214773 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | -4 | 4 | ChEMBL | None | None | None | CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm050921q | |||||
| 73354294 | 107024 | None | 0 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 636 | 11 | 6 | 5 | 4.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CP(=O)(O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
| CHEMBL315055 | 107024 | None | 0 | Mouse | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 636 | 11 | 6 | 5 | 4.2 | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CP(=O)(O)O)c1ccccc1 | 10.1021/jm00092a007 | |||
| 19756868 | 28425 | None | 3 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 409 | 3 | 2 | 4 | 3.5 | CN1C(=O)C(NC(=O)Nc2cccc(C#N)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| CHEMBL137520 | 28425 | None | 3 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 409 | 3 | 2 | 4 | 3.5 | CN1C(=O)C(NC(=O)Nc2cccc(C#N)c2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm00078a018 | |||
| 44281078 | 99797 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 773 | 16 | 4 | 8 | 5.9 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
| CHEMBL284975 | 99797 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 773 | 16 | 4 | 8 | 5.9 | CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(96)00249-1 | |||
| CHEMBL318475 | 213672 | None | 0 | Rat | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | None | None | None | CC(C)(C)OC(=O)N1c2ccccc2C[C@@H]1C(=O)N1[C@H](c2ccccc2)CC[C@@H]1C(=O)N1Cc2ccccc2C[C@@H]1C(=O)NCC(=O)O | 10.1016/S0960-894X(96)00546-X | |||||
| 44210425 | 165389 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 439 | 5 | 2 | 5 | 3.5 | COc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
| CHEMBL423278 | 165389 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 439 | 5 | 2 | 5 | 3.5 | COc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 | 10.1016/S0960-894X(00)80683-6 | |||
| 10626598 | 51792 | None | 0 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 555 | 8 | 3 | 5 | 5.4 | COC(=O)/C(=C/c1ccccc1)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1016/S0960-894X(01)81250-6 | |||
| CHEMBL158491 | 51792 | None | 0 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 555 | 8 | 3 | 5 | 5.4 | COC(=O)/C(=C/c1ccccc1)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 | 10.1016/S0960-894X(01)81250-6 | |||
| 44333341 | 107842 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 448 | 4 | 2 | 5 | 2.9 | CCCN1C(=O)[C@@H](NC(=O)Nc2cccc(C)c2)N=C(N2CCN(C)CC2)c2ccccc21 | 10.1016/0960-894X(95)00530-0 | |||
| CHEMBL319180 | 107842 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 448 | 4 | 2 | 5 | 2.9 | CCCN1C(=O)[C@@H](NC(=O)Nc2cccc(C)c2)N=C(N2CCN(C)CC2)c2ccccc21 | 10.1016/0960-894X(95)00530-0 | |||
| 443375 | 210065 | None | 33 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | 2 | 5 | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm000937a | |||
| CHEMBL9506 | 210065 | None | 33 | Mouse | Binding | pIC50 | = | 6.6 | 6.6 | 2 | 5 | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1021/jm000937a | |||
| 5279169 | 26207 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 404 | 3 | 3 | 3 | 4.3 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00078a018 | |||
| CHEMBL135715 | 26207 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 404 | 3 | 3 | 3 | 4.3 | O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2NC1=O | 10.1021/jm00078a018 | |||
| 44381949 | 120788 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 474 | 3 | 3 | 4 | 4.6 | CN1C(=O)[C@H](NC(=O)Nc2cc3c4ccccc4nc-3c[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
| CHEMBL354802 | 120788 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 474 | 3 | 3 | 4 | 4.6 | CN1C(=O)[C@H](NC(=O)Nc2cc3c4ccccc4nc-3c[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80682-4 | |||
| 443375 | 210065 | None | 33 | Human | Binding | pIC50 | = | 6.6 | 6.6 | -316 | 5 | ChEMBL | 408 | 3 | 2 | 3 | 3.7 | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 | 10.1016/S0960-894X(00)80684-8 | |||
| CHEMBL9506 | 210065 | None | 33 | Human | Binding | pIC50 | = | 6.6 | 6.6 | -316 | 5 | |||||||||||