Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL2372983 ccr5_human Human No 9.7 EC50 = 0.2 nM Bind
Effective concentration for antagonistic activity by inhibition of T-tropic strain of HIV-1 through its specific binding to a chemokine receptorEffective concentration for antagonistic activity by inhibition of T-tropic strain of HIV-1 through its specific binding to a chemokine receptor
None None None NCCCC[C@@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C1=O
CHEMBL425618 ccr5_human Human Yes 9.0 EC50 = 1 nM Bind
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
513 8 1 5 6.0 Cc1nnc(C(C)C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1
CHEMBL99384 ccr5_human Human Yes 6.0 EC50 = 1000 nM Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
236 0 0 2 4.0 Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C
CHEMBL2205801 ccr5_human Human Yes 5.0 EC50 = 10000 nM Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
236 2 0 4 2.4 O=Cc1ccnc2c1ccc1c(C=O)ccnc12
CHEMBL220199 ccr5_human Human Yes 6.0 EC50 = 1100 nM Funct
Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayAgonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assay
475 7 1 6 4.4 Cc1ccc(CN2CCC(CNC(=O)C3CCN(c4ccc(-c5cccs5)nn4)CC3)C2)cc1
CHEMBL101165 ccr5_human Human Yes 5.0 EC50 = 11000 nM Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1
CHEMBL4061273 ccr5_human Human No 5.0 EC50 = 11220 nM Bind
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
485 9 1 6 5.3 CC(=O)Oc1ccc(/C=C/C(=O)CCc2ccc(NC(=O)c3ccc(C)cc3)cc2)cc1OC(C)=O
CHEMBL101165 ccr5_human Human Yes 4.9 EC50 = 12589.3 nM Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1
CHEMBL219769 ccr5_human Human Yes 4.9 EC50 = 13500 nM Funct
Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayAgonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assay
435 7 1 6 3.8 Cc1ccc(-n2c(C)nnc2SCC(=O)NC2CCN(Cc3ccccc3)CC2)cc1
CHEMBL4094196 ccr5_human Human No 4.8 EC50 = 15990 nM Bind
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
493 11 1 7 4.9 CC(=O)Oc1ccc(CCC(=O)CCc2ccc(NC(=O)Cc3cccs3)cc2)cc1OC(C)=O
CHEMBL4069939 ccr5_human Human No 4.8 EC50 = 16250 nM Bind
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
516 10 1 8 4.9 CC(=O)Oc1ccc(/C=C/C(=O)CCc2ccc(NC(=O)c3ccc([N+](=O)[O-])cc3)cc2)cc1OC(C)=O
CHEMBL4095938 ccr5_human Human No 4.8 EC50 = 16560 nM Bind
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
417 8 3 5 4.6 COc1ccc(C(=O)Nc2ccc(CCC(=O)/C=C/c3ccc(O)c(O)c3)cc2)cc1
CHEMBL4062349 ccr5_human Human No 4.8 EC50 = 16830 nM Bind
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
518 11 1 8 4.8 CC(=O)Oc1ccc(CCC(=O)CCc2ccc(NC(=O)c3ccc([N+](=O)[O-])cc3)cc2)cc1OC(C)=O
CHEMBL316589 ccr5_human Human Yes 5.8 EC50 = 1800 nM Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
194 0 0 2 3.1 Cc1ccnc2c1ccc1cccnc12
CHEMBL4083941 ccr5_human Human No 4.7 EC50 = 18340 nM Bind
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
395 8 3 4 4.8 O=C(CCc1ccc(NC(=O)C2CCCCC2)cc1)CCc1ccc(O)c(O)c1
CHEMBL4084066 ccr5_human Human No 4.7 EC50 = 18770 nM Bind
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
479 10 1 6 5.2 CC(=O)Oc1ccc(CCC(=O)CCc2ccc(NC(=O)C3CCCCC3)cc2)cc1OC(C)=O
CHEMBL4081563 ccr5_human Human No 4.7 EC50 = 18850 nM Bind
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
501 10 1 7 5.0 COc1ccc(C(=O)Nc2ccc(CCC(=O)/C=C/c3ccc(OC(C)=O)c(OC(C)=O)c3)cc2)cc1
CHEMBL223686 ccr5_human Human Yes 5.7 EC50 = 1900 nM Funct
Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayAgonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assay
389 9 1 5 4.9 C=C(C)Cc1c(C)c(C#N)c2nc3ccccc3n2c1NCCCN(CC)CC
CHEMBL2205809 ccr5_human Human Yes 5.7 EC50 = 1900 nM Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
208 0 0 2 3.4 Cc1cnc2c(ccc3cc(C)cnc32)c1
CHEMBL39879 ccr5_human Human Yes 4.7 EC50 = 19000 nM Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
156 1 0 2 2.1 c1ccc(-c2ccccn2)nc1
CHEMBL2205809 ccr5_human Human Yes 5.7 EC50 = 1995.3 nM Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
208 0 0 2 3.4 Cc1cnc2c(ccc3cc(C)cnc32)c1
CHEMBL2205810 ccr5_human Human Yes 5.7 EC50 = 1995.3 nM Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
194 0 0 2 3.1 Cc1cnc2c(ccc3cccnc32)c1
CHEMBL316589 ccr5_human Human Yes 5.7 EC50 = 1995.3 nM Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
194 0 0 2 3.1 Cc1ccnc2c1ccc1cccnc12
CHEMBL2205808 ccr5_human Human Yes 4.7 EC50 = 19952.6 nM Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
216 3 0 4 2.2 COc1ccnc(-c2cc(OC)ccn2)c1
CHEMBL39879 ccr5_human Human Yes 4.7 EC50 = 19952.6 nM Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
156 1 0 2 2.1 c1ccc(-c2ccccn2)nc1
CHEMBL219770 ccr5_human Human No 5.7 EC50 = 2000 nM Funct
Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayAgonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assay
450 7 1 7 3.4 Cc1cc(CN2CCN(C)CC2)ccc1NC(=O)CSc1nnc(C)n1-c1ccccc1
CHEMBL2205810 ccr5_human Human Yes 5.7 EC50 = 2200 nM Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
194 0 0 2 3.1 Cc1cnc2c(ccc3cccnc32)c1
CHEMBL2205808 ccr5_human Human Yes 4.7 EC50 = 22000 nM Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
216 3 0 4 2.2 COc1ccnc(-c2cc(OC)ccn2)c1
CHEMBL4073567 ccr5_human Human No 4.6 EC50 = 22840 nM Bind
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
389 8 3 4 4.5 O=C(CCc1ccc(NC(=O)c2ccccc2)cc1)CCc1ccc(O)c(O)c1
CHEMBL2205807 ccr5_human Human Yes 5.6 EC50 = 2300 nM Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1
CHEMBL4086440 ccr5_human Human No 4.6 EC50 = 23140 nM Bind
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
487 10 1 6 5.2 CC(=O)Oc1ccc(CCC(=O)CCc2ccc(NC(=O)c3ccc(C)cc3)cc2)cc1OC(C)=O
CHEMBL4099473 ccr5_human Human No 5.6 EC50 = 2470 nM Funct
Positive allosteric modulation of human CCR5 expressed in HEK293T cells co-expressing CAMYEL assessed as increase in CCL4-induced inhibition of forskolin-stimulated cAMP accumulation after 10 mins by BRET assayPositive allosteric modulation of human CCR5 expressed in HEK293T cells co-expressing CAMYEL assessed as increase in CCL4-induced inhibition of forskolin-stimulated cAMP accumulation after 10 mins by BRET assay
461 7 1 4 4.4 CC(C)CN1CC(C(=O)Nc2ccc(CN(C)C3CCOCC3)cc2)=Cc2ccccc2C1=O
CHEMBL2205807 ccr5_human Human Yes 5.6 EC50 = 2511.9 nM Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1
CHEMBL593442 ccr5_human Human Yes 5.6 EC50 = 2511.9 nM Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12
CHEMBL593442 ccr5_human Human Yes 5.6 EC50 = 2600 nM Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12
CHEMBL89445 ccr5_human Human Yes 4.5 EC50 = 29000 nM Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
233 2 0 3 3.2 c1ccc(-c2cccc(-c3ccccn3)n2)nc1
CHEMBL4089429 ccr5_human Human No 4.5 EC50 = 29670 nM Bind
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
477 9 1 6 5.3 CC(=O)Oc1ccc(/C=C/C(=O)CCc2ccc(NC(=O)C3CCCCC3)cc2)cc1OC(C)=O
CHEMBL219781 ccr5_human Human Yes 5.5 EC50 = 3000 nM Funct
Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayAgonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assay
463 9 1 6 4.7 Cc1ccc(NC(=O)CSc2nnc(CCN3CCCCC3)n2Cc2ccccc2)c(C)c1
CHEMBL4064975 ccr5_human Human No 4.5 EC50 = 30630 nM Bind
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
503 11 1 7 4.9 COc1ccc(C(=O)Nc2ccc(CCC(=O)CCc3ccc(OC(C)=O)c(OC(C)=O)c3)cc2)cc1
CHEMBL89445 ccr5_human Human Yes 4.5 EC50 = 31622.8 nM Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
233 2 0 3 3.2 c1ccc(-c2cccc(-c3ccccn3)n2)nc1
CHEMBL4063935 ccr5_human Human No 4.4 EC50 = 36300 nM Bind
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
403 8 3 4 4.8 Cc1ccc(C(=O)Nc2ccc(CCC(=O)CCc3ccc(O)c(O)c3)cc2)cc1
CHEMBL4531005 ccr5_human Human Yes 8.4 EC50 = 4.5 nM Funct
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)
351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C
CHEMBL4101931 ccr5_human Human No 4.4 EC50 = 42460 nM Bind
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
434 9 3 6 4.4 O=C(CCc1ccc(NC(=O)c2ccc([N+](=O)[O-])cc2)cc1)CCc1ccc(O)c(O)c1
CHEMBL4091826 ccr5_human Human No 5.3 EC50 = 4850 nM Bind
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
473 10 1 6 4.9 CC(=O)Oc1ccc(CCC(=O)CCc2ccc(NC(=O)c3ccccc3)cc2)cc1OC(C)=O
CHEMBL415879 ccr5_human Human Yes 5.3 EC50 = 4900 nM Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
180 0 0 2 2.8 c1cnc2c(c1)ccc1cccnc12
CHEMBL4531005 ccr5_human Human Yes 8.3 EC50 = 5 nM Funct
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)
351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C
CHEMBL4544504 ccr5_human Human Yes 8.3 EC50 = 5 nM Funct
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 30 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 30 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)
395 3 2 5 3.1 CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1
CHEMBL4544504 ccr5_human Human Yes 8.3 EC50 = 5.0 nM Funct
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 30 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 30 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)
395 3 2 5 3.1 CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1
CHEMBL415879 ccr5_human Human Yes 5.3 EC50 = 5011.9 nM Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
180 0 0 2 2.8 c1cnc2c(c1)ccc1cccnc12
CHEMBL4072528 ccr5_human Human No 4.3 EC50 = 55370 nM Bind
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
409 9 3 5 4.5 O=C(CCc1ccc(NC(=O)Cc2cccs2)cc1)CCc1ccc(O)c(O)c1
CHEMBL4544504 ccr5_human Human Yes 8.2 EC50 = 6 nM Funct
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)
395 3 2 5 3.1 CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1
CHEMBL4544504 ccr5_human Human Yes 8.2 EC50 = 6.2 nM Funct
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)
395 3 2 5 3.1 CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1
CHEMBL375781 ccr5_human Human Yes 4.2 EC50 = 63095.7 nM Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
208 0 0 2 3.4 Cc1ccc2ccc3ccc(C)nc3c2n1
CHEMBL375781 ccr5_human Human Yes 4.2 EC50 = 67000 nM Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
208 0 0 2 3.4 Cc1ccc2ccc3ccc(C)nc3c2n1
CHEMBL1178786 ccr5_human Human Yes 8.2 EC50 = 7 nM Funct
Positive allosteric modulation of human CCR5 expressed in HEK293T cells co-expressing CAMYEL assessed as increase in CCL4-induced inhibition of forskolin-stimulated cAMP accumulation after 10 mins by BRET assayPositive allosteric modulation of human CCR5 expressed in HEK293T cells co-expressing CAMYEL assessed as increase in CCL4-induced inhibition of forskolin-stimulated cAMP accumulation after 10 mins by BRET assay
495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C
CHEMBL4531005 ccr5_human Human Yes 8.1 EC50 = 7.2 nM Funct
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 1000 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 1000 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)
351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C
CHEMBL4531005 ccr5_human Human Yes 8.1 EC50 = 7.2 nM Funct
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)
351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C
CHEMBL4531005 ccr5_human Human Yes 8.1 EC50 = 8 nM Funct
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)
351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C
CHEMBL4544504 ccr5_human Human Yes 8.1 EC50 = 8.9 nM Funct
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)
395 3 2 5 3.1 CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1
CHEMBL4531005 ccr5_human Human Yes 8.1 EC50 = 9 nM Funct
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 1000 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 1000 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)
351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C
CHEMBL4544504 ccr5_human Human Yes 8.1 EC50 = 9 nM Funct
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)
395 3 2 5 3.1 CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1
CHEMBL311795 ccr5_human Human Yes 11.0 IC50 = 0.0 nM Bind
Inhibition of 0.1 nM of MIP-1beta induced migration of recombinant mouse pro-B cell line BA/F3 expressing human CCR5Inhibition of 0.1 nM of MIP-1beta induced migration of recombinant mouse pro-B cell line BA/F3 expressing human CCR5
503 4 0 5 4.9 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1
CHEMBL460845 ccr5_human Human No 10.3 IC50 = 0.1 nM Bind
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
543 10 1 3 6.3 CCN(C(=O)Cc1ccc(Cl)c(Cl)c1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1
CHEMBL21106 ccr5_human Human No 10.2 IC50 = 0.1 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
546 11 1 3 6.5 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL21106 ccr5_human Human No 10.2 IC50 = 0.1 nM Bind
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
546 11 1 3 6.5 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL21106 ccr5_human Human No 10.2 IC50 = 0.1 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
546 11 1 3 6.5 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL457043 ccr5_human Human No 10.2 IC50 = 0.1 nM Bind
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
553 11 1 5 4.4 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1
CHEMBL2164207 ccr5_human Human No 10.1 IC50 = 0.1 nM Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
527 9 2 6 4.5 CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2Cl)CC1
CHEMBL1926899 ccr5_human Human No 10.1 IC50 = 0.1 nM Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
600 12 2 7 5.2 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(C(=O)NC(C)C)nc3C)CC2)cc1
CHEMBL20345 ccr5_human Human No 10.0 IC50 = 0.1 nM Bind
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
542 11 1 4 6.5 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCSc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL20896 ccr5_human Human Yes 10.0 IC50 = 0.1 nM Bind
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
488 11 1 3 6.1 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL1649924 ccr5_human Human No 10.0 IC50 = 0.1 nM Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
497 6 1 6 3.9 COC(=O)N1CCc2nc(C)n([C@@H]3C[C@@H]4CC[C@H](C3)N4CC[C@H](NC(C)=O)c3cccc(F)c3)c2C1
CHEMBL2164202 ccr5_human Human No 10.0 IC50 = 0.1 nM Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
561 10 1 7 3.9 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)CN2CCOC2=O)CC1
CHEMBL2164210 ccr5_human Human No 10.0 IC50 = 0.1 nM Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
518 9 2 7 3.7 CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(C#N)nc2Cl)CC1
CHEMBL20896 ccr5_human Human Yes 10.0 IC50 = 0.1 nM Bind
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
488 11 1 3 6.1 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL20345 ccr5_human Human No 10.0 IC50 = 0.1 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
542 11 1 4 6.5 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCSc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL316475 ccr5_human Human No 10.0 IC50 = 0.1 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
474 11 1 3 5.7 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL320386 ccr5_human Human Yes 10.0 IC50 = 0.1 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
474 10 1 3 5.7 O=C(O)[C@@H](C1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL102826 ccr5_human Human Yes 10.0 IC50 = 0.1 nM Bind
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
502 10 1 3 6.5 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL20896 ccr5_human Human Yes 10.0 IC50 = 0.1 nM Bind
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
488 11 1 3 6.1 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL316475 ccr5_human Human No 10.0 IC50 = 0.1 nM Bind
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
474 11 1 3 5.7 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL320386 ccr5_human Human Yes 10.0 IC50 = 0.1 nM Bind
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
474 10 1 3 5.7 O=C(O)[C@@H](C1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL2110727 ccr5_human Human Yes 10.0 IC50 = 0.1 nM Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC
CHEMBL328445 ccr5_human Human Yes 10.0 IC50 = 0.1 nM Bind
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
568 11 0 6 6.1 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(Cc3ccccc3)C[C@@H]2c2ccccc2)CC1
CHEMBL93139 ccr5_human Human Yes 10.0 IC50 = 0.1 nM Bind
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
634 14 0 7 5.9 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(CC[C@](C)(CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL2164217 ccr5_human Human No 10.0 IC50 = 0.1 nM Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
554 9 2 6 5.5 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)Nc2cccnc2)CC1
CHEMBL157491 ccr5_human Human No 9.9 IC50 = 0.1 nM Bind
Ability to displace [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesAbility to displace [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
588 9 0 7 6.3 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN3OC4(CCCCC4)C[C@H]3[C@@H]2c2ccccc2)CC1
CHEMBL473558 ccr5_human Human No 9.9 IC50 = 0.1 nM Bind
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
451 8 1 5 5.2 Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CCCC2)c2ccccc2)CC1
CHEMBL461687 ccr5_human Human No 9.8 IC50 = 0.2 nM Bind
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
490 10 2 3 5.1 CCN(C(=O)NCc1ccccc1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1
CHEMBL2178577 ccr5_human Human No 9.8 IC50 = 0.2 nM Bind
Binding affinity to CCR5Binding affinity to CCR5
638 11 0 6 5.0 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cc(F)cc(F)c2)C2CCC(S(C)(=O)=O)CC2)CC1
CHEMBL3085308 ccr5_human Human No 9.7 IC50 = 0.2 nM Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
697 17 1 8 8.1 CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4nncn4CCC)cc2)CCCN3CC(C)C)cc1
CHEMBL20622 ccr5_human Human No 9.7 IC50 = 0.2 nM Bind
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
542 11 1 3 6.8 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL21147 ccr5_human Human No 9.7 IC50 = 0.2 nM Bind
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
574 11 1 3 7.2 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccc(C(F)(F)F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL1926893 ccr5_human Human No 9.7 IC50 = 0.2 nM Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
549 10 1 6 5.7 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)cc1
CHEMBL1201187 ccr5_human Human No 9.7 IC50 = 0.2 nM Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
513 8 1 5 6.0 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1
CHEMBL1649926 ccr5_human Human No 9.7 IC50 = 0.2 nM Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
497 6 1 6 3.9 COC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(C)=O)CC3)C2)c1cccc(F)c1
CHEMBL1649927 ccr5_human Human No 9.7 IC50 = 0.2 nM Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
513 6 1 7 4.1 COC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(=O)OC)CC3)C2)c1cccc(F)c1
CHEMBL1201187 ccr5_human Human No 9.7 IC50 = 0.2 nM Bind
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
513 8 1 5 6.0 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1
CHEMBL319593 ccr5_human Human No 9.7 IC50 = 0.2 nM Bind
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
542 10 2 6 5.3 OC1(CCCc2ccc(-c3nnn[nH]3)cc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL322422 ccr5_human Human No 9.7 IC50 = 0.2 nM Bind
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
556 10 1 7 5.3 Cn1nnnc1-c1ccc(CCCC2(O)CCN(C[C@H]3CN(CC4CCCCC4)C[C@@H]3c3ccccc3)CC2)cc1
CHEMBL20622 ccr5_human Human No 9.7 IC50 = 0.2 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
542 11 1 3 6.8 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL21147 ccr5_human Human No 9.7 IC50 = 0.2 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
574 11 1 3 7.2 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccc(C(F)(F)F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL319593 ccr5_human Human No 9.7 IC50 = 0.2 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
542 10 2 6 5.3 OC1(CCCc2ccc(-c3nnn[nH]3)cc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL99909 ccr5_human Human Yes 9.7 IC50 = 0.2 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
488 10 1 3 6.1 O=C(O)[C@@H](C1CCCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL319593 ccr5_human Human No 9.7 IC50 = 0.2 nM Bind
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
542 10 2 6 5.3 OC1(CCCc2ccc(-c3nnn[nH]3)cc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL99909 ccr5_human Human Yes 9.7 IC50 = 0.2 nM Bind
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
488 10 1 3 6.1 O=C(O)[C@@H](C1CCCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL1201187 ccr5_human Human No 9.7 IC50 = 0.2 nM Funct
Inhibition of CCR5 in human TZM-bl cells infected with HIV1 Bal R5 assessed as antiviral activity by measuring reduction in viral infection pre-incubated with cells followed by viral infection measured after 3 days by luciferase reporter gene assayInhibition of CCR5 in human TZM-bl cells infected with HIV1 Bal R5 assessed as antiviral activity by measuring reduction in viral infection pre-incubated with cells followed by viral infection measured after 3 days by luciferase reporter gene assay
513 8 1 5 6.0 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1
CHEMBL102826 ccr5_human Human Yes 9.7 IC50 = 0.2 nM Bind
Inhibition of human CX3C chemokine receptor 5 from GP120-membrane-based assayInhibition of human CX3C chemokine receptor 5 from GP120-membrane-based assay
502 10 1 3 6.5 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL2110727 ccr5_human Human Yes 9.7 IC50 = 0.2 nM Funct
Inhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cellsInhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cells
696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC
CHEMBL171958 ccr5_human Human Yes 9.7 IC50 = 0.2 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
642 12 1 6 7.1 CCn1nc(Cc2ccc(OC3CC3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL173400 ccr5_human Human Yes 9.7 IC50 = 0.2 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
610 11 1 5 7.2 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc5ccccc5c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL174927 ccr5_human Human Yes 9.7 IC50 = 0.2 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
610 9 1 5 7.2 CCn1nc(Cc2cccc3ccccc23)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL366770 ccr5_human Human Yes 9.7 IC50 = 0.2 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
610 11 1 5 7.2 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4cccc5ccccc45)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL369235 ccr5_human Human Yes 9.7 IC50 = 0.2 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
610 9 1 5 7.2 CCn1nc(Cc2ccc3ccccc3c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL329893 ccr5_human Human Yes 9.7 IC50 = 0.2 nM Bind
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
574 10 0 6 5.6 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL431852 ccr5_human Human Yes 9.7 IC50 = 0.2 nM Bind
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
582 10 0 6 5.7 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)c3ccccc3)C[C@@H]2c2ccccc2)CC1
CHEMBL3085309 ccr5_human Human No 9.7 IC50 = 0.2 nM Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
734 17 1 9 8.0 CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCN3Cc2cnn(C)c2)cc1
CHEMBL212731 ccr5_human Human No 9.7 IC50 = 0.2 nM Bind
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
614 11 0 6 4.7 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cccc(F)c2)CC1
CHEMBL511493 ccr5_human Human Yes 9.6 IC50 = 0.2 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
543 10 1 5 6.3 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1
CHEMBL520091 ccr5_human Human Yes 9.6 IC50 = 0.2 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
529 10 1 5 5.9 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1
CHEMBL326487 ccr5_human Human No 9.6 IC50 = 0.2 nM Bind
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
529 10 1 5 5.9 O=C(O)C(CC1CC1)N1CC(c2ccccc2)[C@@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)C1
CHEMBL333619 ccr5_human Human No 9.6 IC50 = 0.2 nM Bind
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
543 10 1 5 6.3 O=C(O)C(CC1CCC1)N1CC(c2ccccc2)[C@@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)C1
CHEMBL511493 ccr5_human Human Yes 9.6 IC50 = 0.2 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
543 10 1 5 6.3 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1
CHEMBL520091 ccr5_human Human Yes 9.6 IC50 = 0.2 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
529 10 1 5 5.9 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1
CHEMBL3085307 ccr5_human Human No 9.6 IC50 = 0.2 nM Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
682 17 1 7 8.5 CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCN3CCC)cc1
CHEMBL2110727 ccr5_mouse Mouse Yes 9.6 IC50 = 0.3 nM Bind
Displacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hrDisplacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hr
696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC
CHEMBL1951914 ccr5_human Human No 9.6 IC50 = 0.3 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
639 11 0 6 4.1 CCN(C(=O)Cc1ccc(cc1)S(=O)(=O)C)C1CCN(CC1)CC[C@@H](c1cc(F)cc(c1)F)C1CCN(CC1)S(=O)(=O)C
CHEMBL480503 ccr5_human Human Yes 9.5 IC50 = 0.3 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
557 9 1 5 6.7 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1
CHEMBL480503 ccr5_human Human Yes 9.5 IC50 = 0.3 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
557 9 1 5 6.7 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1
CHEMBL480503 ccr5_human Human Yes 9.5 IC50 = 0.3 nM Bind
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
557 9 1 5 6.7 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1
CHEMBL21117 ccr5_human Human No 9.5 IC50 = 0.3 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
560 11 1 3 6.9 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL455073 ccr5_human Human No 9.5 IC50 = 0.3 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
570 11 1 3 7.5 O=C(O)[C@@H](CC1CCCCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL20988 ccr5_human Human No 9.5 IC50 = 0.3 nM Bind
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
531 11 1 4 6.1 N#Cc1ccc(CCCC2CCN(C[C@H]3CN([C@H](CC4CCC4)C(=O)O)C[C@@H]3c3cccc(F)c3)CC2)cc1
CHEMBL21117 ccr5_human Human No 9.5 IC50 = 0.3 nM Bind
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
560 11 1 3 6.9 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL282921 ccr5_human Human No 9.5 IC50 = 0.3 nM Bind
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
556 10 1 3 7.2 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL1926896 ccr5_human Human No 9.5 IC50 = 0.3 nM Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
533 10 1 6 5.2 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(F)nc3C)CC2)cc1
CHEMBL1926898 ccr5_human Human No 9.5 IC50 = 0.3 nM Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
540 10 1 7 5.0 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(C#N)nc3C)CC2)cc1
CHEMBL1927008 ccr5_human Human No 9.5 IC50 = 0.3 nM Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
551 10 1 8 4.5 COc1ccc(N(Cc2cccc(C#N)n2)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(C#N)nc3C)CC2)cc1
CHEMBL1927009 ccr5_human Human No 9.5 IC50 = 0.3 nM Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
560 10 1 7 5.3 COc1ccc(N(Cc2cccc(C#N)n2)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)cc1
CHEMBL1649922 ccr5_human Human No 9.5 IC50 = 0.3 nM Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
479 6 1 6 3.8 COC(=O)N1CCc2nc(C)n([C@@H]3C[C@@H]4CC[C@H](C3)N4CC[C@H](NC(C)=O)c3ccccc3)c2C1
CHEMBL2164203 ccr5_human Human No 9.5 IC50 = 0.3 nM Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
491 8 2 5 4.2 CNC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1
CHEMBL2164205 ccr5_human Human No 9.5 IC50 = 0.3 nM Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
493 8 3 6 4.0 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)NO)CC1
CHEMBL2164206 ccr5_human Human No 9.5 IC50 = 0.3 nM Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
507 9 2 6 4.2 CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1
CHEMBL2164211 ccr5_human Human No 9.5 IC50 = 0.3 nM Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
551 12 2 7 4.2 COCCONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1
CHEMBL194497 ccr5_human Human No 9.5 IC50 = 0.3 nM Bind
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
522 8 1 5 5.2 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccc(F)cn34)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL317710 ccr5_human Human Yes 9.5 IC50 = 0.3 nM Bind
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes.Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes.
474 9 1 3 6.1 OC1(CCCc2ccccc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL21117 ccr5_human Human No 9.5 IC50 = 0.3 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
560 11 1 3 6.9 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL455073 ccr5_human Human No 9.5 IC50 = 0.3 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
570 11 1 3 7.5 O=C(O)[C@@H](CC1CCCCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL2435848 ccr5_human Human No 9.5 IC50 = 0.3 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
591 5 0 4 6.6 Cc1cc(Cl)nc(C)c1C(=O)N1CCC(C)(N2CCC(N3C(=O)N(C4CCCCC4)C[C@H]3c3ccccc3)CC2)CC1
CHEMBL172894 ccr5_human Human Yes 9.5 IC50 = 0.3 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
610 11 1 5 7.2 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc5ccccc5c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL172916 ccr5_human Human Yes 9.5 IC50 = 0.3 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
616 13 1 6 6.6 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC5CC5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL174004 ccr5_human Human Yes 9.5 IC50 = 0.3 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
636 12 1 5 7.7 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(-c5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL177127 ccr5_human Human Yes 9.5 IC50 = 0.3 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
626 13 1 6 6.6 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL279992 ccr5_human Human Yes 9.5 IC50 = 0.3 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
616 11 1 5 7.3 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C(C)(C)C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL366868 ccr5_human Human Yes 9.5 IC50 = 0.3 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
602 12 1 5 7.2 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C(C)C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL367987 ccr5_human Human Yes 9.5 IC50 = 0.3 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
622 11 1 5 7.3 CCn1nc(Cc2ccc(-c3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL368329 ccr5_human Human Yes 9.5 IC50 = 0.3 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
662 11 1 5 8.2 CCn1nc(Cc2ccc(-c3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL369059 ccr5_human Human Yes 9.5 IC50 = 0.3 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
616 13 1 6 6.6 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC5CC5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL427493 ccr5_human Human Yes 9.5 IC50 = 0.3 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
628 9 1 5 7.0 CCn1nc(Cc2ccc(C(F)(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL435472 ccr5_human Human Yes 9.5 IC50 = 0.3 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
574 11 1 5 6.3 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL212689 ccr5_human Human Yes 9.5 IC50 = 0.3 nM Bind
Binding affinity to CCR5Binding affinity to CCR5
632 11 0 6 4.8 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cc(F)cc(F)c2)CC1
CHEMBL212689 ccr5_human Human Yes 9.5 IC50 = 0.3 nM Bind
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
632 11 0 6 4.8 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cc(F)cc(F)c2)CC1
CHEMBL212689 ccr5_human Human Yes 9.5 IC50 = 0.3 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
632 11 0 6 4.8 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cc(F)cc(F)c2)CC1
CHEMBL480693 ccr5_human Human Yes 9.5 IC50 = 0.3 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
527 10 1 5 5.8 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)o3)CC2)[C@@H](c2ccccc2)C1
CHEMBL459384 ccr5_human Human No 9.5 IC50 = 0.3 nM Bind
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
509 10 1 3 5.6 CCN(C(=O)Cc1ccc(Cl)cc1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1
CHEMBL480693 ccr5_human Human Yes 9.5 IC50 = 0.3 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
527 10 1 5 5.8 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)o3)CC2)[C@@H](c2ccccc2)C1
CHEMBL480693 ccr5_human Human Yes 9.5 IC50 = 0.3 nM Bind
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
527 10 1 5 5.8 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)o3)CC2)[C@@H](c2ccccc2)C1
CHEMBL193984 ccr5_human Human No 9.5 IC50 = 0.4 nM Bind
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
532 9 1 5 5.6 CCc1ccn2c(C3CCN(C[C@H]4CN([C@H](CC5CCC5)C(=O)O)C[C@@H]4c4cccc(F)c4)CC3)cnc2c1
CHEMBL1784385 ccr5_human Human No 9.5 IC50 = 0.4 nM Bind
Displacement of 125I-MIP-1beta from human CCR5 receptor after 4 hrs by scintillation countingDisplacement of 125I-MIP-1beta from human CCR5 receptor after 4 hrs by scintillation counting
512 5 0 4 6.5 Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CCC1(c2ccccc2)CCN(C(=O)C(C)(C)C)CC1
CHEMBL1201187 ccr5_human Human No 9.4 IC50 = 0.4 nM Bind
Antagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 MGC26-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assayAntagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 MGC26-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assay
513 8 1 5 6.0 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1
CHEMBL489513 ccr5_human Human No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
473 8 1 5 5.0 Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CC(F)(F)C2)c2ccccc2)CC1
CHEMBL491679 ccr5_human Human No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
473 8 1 5 5.0 Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CC(F)(F)C2)c2ccccc2)CC1
CHEMBL2112559 ccr5_human Human Yes 9.4 IC50 = 0.4 nM Bind
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
526 10 2 4 5.5 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3c[nH]c(Cc4ccccc4)n3)CC2)[C@@H](c2ccccc2)C1
CHEMBL20453 ccr5_human Human No 9.4 IC50 = 0.4 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
526 11 2 4 5.5 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL464132 ccr5_human Human No 9.4 IC50 = 0.4 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
556 10 1 7 5.3 Cn1nnc(-c2ccc(CCCC3(O)CCN(C[C@H]4CN(CC5CCCCC5)C[C@@H]4c4ccccc4)CC3)cc2)n1
CHEMBL20453 ccr5_human Human No 9.4 IC50 = 0.4 nM Bind
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
526 11 2 4 5.5 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL278117 ccr5_human Human No 9.4 IC50 = 0.4 nM Bind
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
558 11 1 4 5.5 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CC[S+]([O-])c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL1288663 ccr5_human Human No 9.4 IC50 = 0.4 nM Funct
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
848 11 2 6 8.2 CC(C)(C)NS(=O)(=O)c1cc(C(=O)N2CCC(CCN3CCC(N(C(=O)NCc4ccc(C#N)cc4)c4cccc(F)c4)CC3)(c3cccc(F)c3)CC2)c(Cl)cc1F
CHEMBL257000 ccr5_human Human No 9.4 IC50 = 0.4 nM Funct
Antagonist activity at CCR5 receptor by [35S]GTP-gamma-S binding assayAntagonist activity at CCR5 receptor by [35S]GTP-gamma-S binding assay
608 7 1 5 6.4 CC(=O)N1CCc2c(nc(C)n2[C@H]2C[C@@H]3CC[C@H](C2)N3CCCN(C(=O)Nc2ccc(C(F)(F)F)cc2)c2ccccc2)C1
CHEMBL1649919 ccr5_human Human No 9.4 IC50 = 0.4 nM Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
463 6 1 5 3.5 CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(C)=O)CC3)C2)c1ccccc1
CHEMBL1649920 ccr5_human Human No 9.4 IC50 = 0.4 nM Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
477 7 1 5 3.9 CCC(=O)N1CCc2nc(C)n([C@@H]3C[C@@H]4CC[C@H](C3)N4CC[C@H](NC(C)=O)c3ccccc3)c2C1
CHEMBL1649921 ccr5_human Human No 9.4 IC50 = 0.4 nM Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
491 7 1 5 4.2 CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(=O)C(C)C)CC3)C2)c1ccccc1
CHEMBL2164208 ccr5_human Human No 9.4 IC50 = 0.4 nM Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
558 11 3 7 3.6 CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(C(=O)NC(C)C)nc2C)CC1
CHEMBL2164209 ccr5_human Human No 9.4 IC50 = 0.4 nM Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
543 9 2 6 3.7 CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)[n+]([O-])c2Cl)CC1
CHEMBL2164219 ccr5_human Human No 9.4 IC50 = 0.4 nM Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
506 10 1 6 4.1 COCC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1
CHEMBL2164220 ccr5_human Human No 9.4 IC50 = 0.4 nM Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
501 9 1 6 4.3 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)CC#N)CC1
CHEMBL344261 ccr5_human Human No 9.4 IC50 = 0.4 nM Bind
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
541 11 1 6 4.8 CCCN(c1ncc(F)cn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL1255794 ccr5_mouse Mouse Yes 9.4 IC50 = 0.4 nM Bind
Displacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hrDisplacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hr
577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O
CHEMBL103790 ccr5_human Human No 9.4 IC50 = 0.4 nM Bind
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
557 10 2 5 4.7 C[n+]1n[nH]c(-c2ccc(CCCC3(O)CCN(C[C@H]4CN(CC5CCCCC5)C[C@@H]4c4ccccc4)CC3)cc2)n1
CHEMBL20453 ccr5_human Human No 9.4 IC50 = 0.4 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
526 11 2 4 5.5 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL464132 ccr5_human Human No 9.4 IC50 = 0.4 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
556 10 1 7 5.3 Cn1nnc(-c2ccc(CCCC3(O)CCN(C[C@H]4CN(CC5CCCCC5)C[C@@H]4c4ccccc4)CC3)cc2)n1
CHEMBL2435857 ccr5_human Human No 9.4 IC50 = 0.4 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
586 8 1 6 5.9 Cc1nc(Sc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2ccccc2)CC1
CHEMBL174214 ccr5_human Human Yes 9.4 IC50 = 0.4 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
616 9 1 5 7.3 CCn1nc(Cc2ccc(C(C)(C)C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL175348 ccr5_human Human Yes 9.4 IC50 = 0.4 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
608 12 1 6 6.2 CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1F
CHEMBL176459 ccr5_human Human Yes 9.4 IC50 = 0.4 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
630 13 1 6 7.0 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC5CCC5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL176669 ccr5_human Human Yes 9.4 IC50 = 0.4 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
622 13 1 6 6.6 CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1F
CHEMBL262402 ccr5_human Human Yes 9.4 IC50 = 0.4 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
652 11 1 6 7.8 CCn1nc(Cc2ccc(Oc3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL366611 ccr5_human Human Yes 9.4 IC50 = 0.4 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
610 11 1 5 7.2 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4cccc5ccccc45)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL366873 ccr5_human Human Yes 9.4 IC50 = 0.4 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
616 11 1 6 6.6 CCn1nc(Cc2ccc(OC3CC3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL369812 ccr5_human Human Yes 9.4 IC50 = 0.4 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
652 13 1 6 7.8 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(Oc5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL433793 ccr5_human Human Yes 9.4 IC50 = 0.4 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
604 11 1 6 6.4 CCOc1cccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)c1
CHEMBL2113086 ccr5_human Human No 9.4 IC50 = 0.4 nM Bind
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
504 8 1 5 5.0 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccccn34)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL207004 ccr5_human Human Yes 9.4 IC50 = 0.4 nM Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
552 9 1 4 4.7 CC(=O)N1CCC(CC1)C(=O)N(c1ccc(c(c1)Cl)C)CCCN1CCC(CC1)Cc1ccc(cc1)C(=O)N
CHEMBL1201187 ccr5_human Human No 9.4 IC50 = 0.4 nM Bind
Antagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 YU2-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assayAntagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 YU2-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assay
513 8 1 5 6.0 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1
CHEMBL1951913 ccr5_human Human No 9.4 IC50 = 0.4 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
617 11 0 6 4.1 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cccc(C)c2)C2CCN(S(C)(=O)=O)CC2)CC1
CHEMBL82301 ccr5_human Human Yes 9.4 IC50 = 0.5 nM Bind
Binding affinity to CCR5Binding affinity to CCR5
533 6 0 6 4.5 COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F
CHEMBL456226 ccr5_human Human No 9.3 IC50 = 0.5 nM Bind
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
543 10 1 3 6.0 CCN(C(=O)Cc1ccc(C(F)(F)F)cc1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1
CHEMBL491319 ccr5_human Human No 9.3 IC50 = 0.5 nM Bind
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
473 8 1 5 5.0 Cc1nnc(C(C)C)n1C1CCN([C@H](C)C[C@H](NC(=O)C2CC(F)(F)C2)c2ccccc2)CC1
CHEMBL3085311 ccr5_human Human No 9.3 IC50 = 0.5 nM Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
710 17 1 7 9.1 CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCCN3CC(C)C)cc1
CHEMBL20831 ccr5_human Human No 9.3 IC50 = 0.5 nM Bind
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
534 10 1 3 6.4 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL278085 ccr5_human Human No 9.3 IC50 = 0.5 nM Bind
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
506 11 1 3 6.2 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL278117 ccr5_human Human No 9.3 IC50 = 0.5 nM Bind
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
558 11 1 4 5.5 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CC[S+]([O-])c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL1649913 ccr5_human Human No 9.3 IC50 = 0.5 nM Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
416 6 1 4 4.8 CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3ccccc31)C2)c1ccccc1
CHEMBL2164212 ccr5_human Human No 9.3 IC50 = 0.5 nM Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
611 11 3 6 5.5 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)NCc2ccc(C(=O)O)cc2)CC1
CHEMBL472464 ccr5_human Human No 9.3 IC50 = 0.5 nM Bind
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
487 6 0 3 5.2 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)C(=O)C3CC3)CC2)CC1
CHEMBL292625 ccr5_human Human Yes 9.3 IC50 = 0.5 nM Funct
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
483 4 1 3 5.6 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(Br)cc3)CC2)CC1
CHEMBL344641 ccr5_human Human No 9.3 IC50 = 0.5 nM Bind
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
591 11 1 6 5.7 CCCN(c1ncc(C(F)(F)F)cn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL371177 ccr5_human Human No 9.3 IC50 = 0.5 nM Bind
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
572 8 1 5 6.3 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4c(Cl)cc(Cl)cn34)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL278085 ccr5_human Human No 9.3 IC50 = 0.5 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
506 11 1 3 6.2 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL471920 ccr5_human Human No 9.3 IC50 = 0.5 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
548 11 1 3 6.8 CC(C)C[C@H](C(=O)O)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL255429 ccr5_human Human No 9.3 IC50 = 0.5 nM Bind
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
482 5 0 4 6.0 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1
CHEMBL322603 ccr5_human Human Yes 9.3 IC50 = 0.5 nM Bind
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
518 10 2 4 5.6 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(O)(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL2435886 ccr5_human Human No 9.3 IC50 = 0.5 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
565 8 1 4 6.1 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@H]2c2ccccc2)CC1
CHEMBL173091 ccr5_human Human Yes 9.3 IC50 = 0.5 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
658 11 1 6 7.7 CCn1nc(Cc2ccc(OC(C)(C)C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL173479 ccr5_human Human Yes 9.3 IC50 = 0.5 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
678 12 1 6 8.4 CCn1nc(Cc2ccc(Oc3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL173583 ccr5_human Human Yes 9.3 IC50 = 0.5 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
618 14 1 6 6.8 CCCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1
CHEMBL174996 ccr5_human Human Yes 9.3 IC50 = 0.5 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
626 11 1 6 6.6 CCn1nc(Cc2ccc(OC(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL175079 ccr5_human Human Yes 9.3 IC50 = 0.5 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
615 12 1 7 5.9 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC)c(C#N)c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL175341 ccr5_human Human Yes 9.3 IC50 = 0.5 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
604 11 1 7 5.8 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc5c(c4)OCO5)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL176528 ccr5_human Human Yes 9.3 IC50 = 0.5 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
602 10 2 6 6.3 CCn1nc(Cc2ccc(O)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL177071 ccr5_human Human No 9.3 IC50 = 0.5 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
578 9 1 5 6.2 CCn1nc(Cc2ccccc2F)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL265723 ccr5_human Human Yes 9.3 IC50 = 0.5 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
658 13 1 6 7.0 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OCC(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL366610 ccr5_human Human Yes 9.3 IC50 = 0.5 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
628 11 1 5 7.0 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL367416 ccr5_human Human Yes 9.3 IC50 = 0.5 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
636 12 1 5 7.7 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(-c5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL367897 ccr5_human Human No 9.3 IC50 = 0.5 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
589 12 2 6 6.1 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4cccc(NC)c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL368000 ccr5_human Human Yes 9.3 IC50 = 0.5 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
666 14 1 6 7.6 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OCc5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL369398 ccr5_human Human Yes 9.3 IC50 = 0.5 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
612 12 1 6 6.2 CCn1nc(Cc2ccc(OC(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL369478 ccr5_human Human Yes 9.3 IC50 = 0.5 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
628 11 1 5 7.0 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL369593 ccr5_human Human Yes 9.3 IC50 = 0.5 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
652 13 1 6 7.8 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(Oc5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL513564 ccr5_human Human Yes 9.3 IC50 = 0.5 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
517 9 1 5 5.7 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1
CHEMBL513564 ccr5_human Human Yes 9.3 IC50 = 0.5 nM Bind
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
517 9 1 5 5.7 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1
CHEMBL513564 ccr5_human Human Yes 9.3 IC50 = 0.5 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
517 9 1 5 5.7 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1
CHEMBL473759 ccr5_human Human No 9.3 IC50 = 0.5 nM Bind
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
465 8 1 5 5.6 Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CCCCC2)c2ccccc2)CC1
CHEMBL1951917 ccr5_human Human No 9.3 IC50 = 0.6 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
637 11 0 6 4.4 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cccc(Cl)c2)C2CCN(S(C)(=O)=O)CC2)CC1
CHEMBL500631 ccr5_human Human No 9.2 IC50 = 0.6 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
554 11 2 4 6.1 CCc1nc(Cc2ccccc2)[nH]c1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1
CHEMBL2112558 ccr5_human Human Yes 9.2 IC50 = 0.6 nM Bind
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
572 11 2 4 6.2 CCc1[nH]c(Cc2ccccc2)nc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL500631 ccr5_human Human No 9.2 IC50 = 0.6 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
554 11 2 4 6.1 CCc1nc(Cc2ccccc2)[nH]c1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1
CHEMBL472412 ccr5_human Human No 9.2 IC50 = 0.6 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
560 10 2 4 6.2 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3[nH]c(Cc4ccccc4)nc3Cl)CC2)[C@@H](c2ccccc2)C1
CHEMBL1926900 ccr5_human Human No 9.2 IC50 = 0.6 nM Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
593 13 1 7 5.8 COCCOc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)cc1
CHEMBL1649925 ccr5_human Human No 9.2 IC50 = 0.6 nM Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
479 6 1 6 3.8 COC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(C)=O)CC3)C2)c1ccccc1
CHEMBL59511 ccr5_human Human Yes 9.2 IC50 = 0.6 nM Funct
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
537 6 0 5 5.0 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3cccc(C#N)c3)c3ccccc3)CC2)CC1
CHEMBL195753 ccr5_human Human No 9.2 IC50 = 0.6 nM Bind
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
549 9 1 7 4.9 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccc([N+](=O)[O-])cn34)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL472412 ccr5_human Human No 9.2 IC50 = 0.6 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
560 10 2 4 6.2 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3[nH]c(Cc4ccccc4)nc3Cl)CC2)[C@@H](c2ccccc2)C1
CHEMBL59511 ccr5_human Human Yes 9.2 IC50 = 0.6 nM Bind
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
537 6 0 5 5.0 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3cccc(C#N)c3)c3ccccc3)CC2)CC1
CHEMBL2435853 ccr5_human Human No 9.2 IC50 = 0.6 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
604 8 1 6 6.2 Cc1nc(Oc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2cccc(Cl)c2)CC1
CHEMBL2112557 ccr5_human Human Yes 9.2 IC50 = 0.6 nM Bind
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
578 10 2 4 6.3 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3[nH]c(Cc4ccccc4)nc3Cl)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL367837 ccr5_human Human Yes 9.2 IC50 = 0.6 nM Bind
Inhibition of human CX3C chemokine receptor 5 from GP120-membrane-based assayInhibition of human CX3C chemokine receptor 5 from GP120-membrane-based assay
596 12 1 5 7.0 CCCn1ncc(CCc2ccccc2)c1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL352981 ccr5_human Human Yes 9.2 IC50 = 0.6 nM Bind
Inhibitory activity against human CC chemokine receptor 5Inhibitory activity against human CC chemokine receptor 5
582 11 1 5 6.6 CCn1ncc(CCc2ccccc2)c1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL172296 ccr5_human Human Yes 9.2 IC50 = 0.6 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
636 10 1 5 7.7 CCn1nc(Cc2ccc(-c3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL173254 ccr5_human Human Yes 9.2 IC50 = 0.6 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
616 12 1 6 6.6 CCn1nc(Cc2ccc(OC3CCC3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL176426 ccr5_human Human Yes 9.2 IC50 = 0.6 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
644 10 1 6 6.9 CCn1nc(Cc2ccc(OC(F)(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL176933 ccr5_human Human Yes 9.2 IC50 = 0.6 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
658 13 1 6 7.0 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OCC(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL262663 ccr5_human Human Yes 9.2 IC50 = 0.6 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
562 10 2 6 5.3 CCn1nc(Cc2ccc(O)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL263529 ccr5_human Human Yes 9.2 IC50 = 0.6 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
602 10 1 5 7.2 CCn1nc(Cc2ccc(C(C)C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL367560 ccr5_human Human Yes 9.2 IC50 = 0.6 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
626 13 1 6 6.6 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL367700 ccr5_human Human Yes 9.2 IC50 = 0.6 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
604 13 1 6 6.4 CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1
CHEMBL368467 ccr5_human Human Yes 9.2 IC50 = 0.6 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
700 13 1 7 6.9 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(S(=O)(=O)c5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL369494 ccr5_human Human Yes 9.2 IC50 = 0.6 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
574 9 1 5 6.3 CCn1nc(Cc2ccc(C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL369659 ccr5_human Human Yes 9.2 IC50 = 0.6 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
644 12 1 6 6.9 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL408800 ccr5_human Human Yes 9.2 IC50 = 0.6 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
576 11 2 6 5.7 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(O)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL425845 ccr5_human Human Yes 9.2 IC50 = 0.6 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
638 12 1 6 7.4 CCn1nc(Cc2ccc(Oc3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL427122 ccr5_human Human Yes 9.2 IC50 = 0.6 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
658 11 1 6 7.0 CCn1nc(Cc2ccc(OCC(F)(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL520755 ccr5_human Human Yes 9.2 IC50 = 0.7 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
540 9 2 4 5.9 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)[nH]3)CC2)[C@@H](c2ccccc2)C1
CHEMBL520755 ccr5_human Human Yes 9.2 IC50 = 0.7 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
540 9 2 4 5.9 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)[nH]3)CC2)[C@@H](c2ccccc2)C1
CHEMBL520755 ccr5_human Human Yes 9.2 IC50 = 0.7 nM Bind
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
540 9 2 4 5.9 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)[nH]3)CC2)[C@@H](c2ccccc2)C1
CHEMBL1951912 ccr5_human Human No 9.2 IC50 = 0.7 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
621 11 0 6 3.9 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cccc(F)c2)C2CCN(S(C)(=O)=O)CC2)CC1
CHEMBL1951914 ccr5_human Human No 9.2 IC50 = 0.7 nM Funct
Antagonist activity at CCR5 in allo T cells assessed as inhibition of MIP-1beta-induced chemotaxisAntagonist activity at CCR5 in allo T cells assessed as inhibition of MIP-1beta-induced chemotaxis
639 11 0 6 4.1 CCN(C(=O)Cc1ccc(cc1)S(=O)(=O)C)C1CCN(CC1)CC[C@@H](c1cc(F)cc(c1)F)C1CCN(CC1)S(=O)(=O)C
CHEMBL1951915 ccr5_human Human No 9.2 IC50 = 0.7 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
655 11 0 6 4.6 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cc(F)cc(Cl)c2)C2CCN(S(C)(=O)=O)CC2)CC1
CHEMBL318406 ccr5_human Human Yes 9.2 IC50 = 0.7 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
462 10 1 3 5.5 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL1926891 ccr5_human Human No 9.2 IC50 = 0.7 nM Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
535 10 1 6 5.4 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)ccnc3Cl)CC2)cc1
CHEMBL1927010 ccr5_human Human No 9.2 IC50 = 0.7 nM Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
544 10 1 7 4.8 COc1ccc(N(Cc2cccc(C#N)n2)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(F)nc3C)CC2)cc1
CHEMBL2164215 ccr5_human Human No 9.2 IC50 = 0.7 nM Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
560 10 1 6 5.2 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)CC2CCOCC2)CC1
CHEMBL62152 ccr5_human Human Yes 9.2 IC50 = 0.7 nM Funct
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
481 5 0 3 6.6 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1
CHEMBL318406 ccr5_human Human Yes 9.2 IC50 = 0.7 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
462 10 1 3 5.5 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL62152 ccr5_macfa Crab-eating macaque Yes 9.2 IC50 = 0.7 nM Bind
Displacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cellsDisplacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cells
481 5 0 3 6.6 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1
CHEMBL318406 ccr5_human Human Yes 9.2 IC50 = 0.7 nM Bind
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
462 10 1 3 5.5 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL2435856 ccr5_human Human No 9.2 IC50 = 0.7 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
584 9 1 6 5.8 CCc1nc(Oc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2ccccc2)CC1
CHEMBL377914 ccr5_human Human No 9.2 IC50 = 0.7 nM Bind
Inhibition of [125I]MIP-1beta binding to CCR5 expressed in HEK293 cellsInhibition of [125I]MIP-1beta binding to CCR5 expressed in HEK293 cells
451 9 2 3 4.0 O=C(Cc1ccc(F)cc1)NC1CCN(CC[C@H](NC(=O)C2CCC2)c2ccccc2)CC1
CHEMBL2112552 ccr5_human Human Yes 9.2 IC50 = 0.7 nM Bind
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
564 10 2 4 5.9 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(c3[nH]c(Cc4ccccc4)nc3Cl)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL172322 ccr5_human Human Yes 9.2 IC50 = 0.7 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
604 9 1 7 5.8 CCn1nc(Cc2ccc3c(c2)OCO3)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL173308 ccr5_human Human Yes 9.2 IC50 = 0.7 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
622 13 1 6 6.6 CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1F
CHEMBL175394 ccr5_human Human Yes 9.2 IC50 = 0.7 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
644 13 1 6 7.4 CCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C5CCCCC5)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1
CHEMBL177033 ccr5_human Human Yes 9.2 IC50 = 0.7 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
630 11 1 6 7.0 CCn1nc(Cc2ccc(OC3CCC3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL177648 ccr5_human Human Yes 9.2 IC50 = 0.7 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
666 14 1 6 7.6 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OCc5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL349974 ccr5_human Human Yes 9.2 IC50 = 0.7 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
622 11 1 6 6.6 CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1F
CHEMBL368204 ccr5_human Human Yes 9.2 IC50 = 0.7 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
618 11 1 6 6.8 CCn1nc(Cc2ccc(OC(C)C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL435554 ccr5_human Human Yes 9.2 IC50 = 0.7 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
590 10 1 6 6.0 CCn1nc(Cc2cccc(OC)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL2112560 ccr5_human Human Yes 9.1 IC50 = 0.7 nM Bind
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
512 10 2 4 5.1 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(c3c[nH]c(Cc4ccccc4)n3)CC2)[C@@H](c2ccccc2)C1
CHEMBL432360 ccr5_human Human No 9.1 IC50 = 0.8 nM Bind
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
619 14 1 6 5.3 C=CCN(C(=O)NCc1ccc([N+](=O)[O-])cc1)C1CCN(CC[C@@H](CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL2282506 ccr5_human Human No 9.1 IC50 = 0.8 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
605 13 1 6 5.6 C=CCN(C(=O)Nc1ccc([N+](=O)[O-])cc1)C1CCN(CCC(CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL211866 ccr5_human Human No 9.1 IC50 = 0.8 nM Bind
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
596 11 0 6 4.6 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2ccccc2)c2ccc(S(C)(=O)=O)cc2)CC1
CHEMBL471251 ccr5_human Human No 9.1 IC50 = 0.8 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
571 11 1 5 6.8 CCc1nc(Cc2ccccc2)sc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1
CHEMBL2112553 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
589 11 1 5 7.0 CCc1nc(Cc2ccccc2)sc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL471251 ccr5_human Human No 9.1 IC50 = 0.8 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
571 11 1 5 6.8 CCc1nc(Cc2ccccc2)sc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1
CHEMBL2282509 ccr5_human Human No 9.1 IC50 = 0.8 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
620 14 1 6 5.1 CCCN(C(=O)OCc1cccc(C(N)=O)c1)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL101961 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
512 10 2 4 5.4 O=C(O)[C@@H](c1ccccc1)N1C[C@H](CN2CCC(O)(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL172854 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
560 9 1 5 6.0 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL281607 ccr5_human Human No 9.1 IC50 = 0.8 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
524 11 1 3 6.4 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL471909 ccr5_human Human No 9.1 IC50 = 0.8 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
530 11 1 4 6.4 CC(C)C[C@H](C(=O)O)N1C[C@H](CN2CCC(CCSc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL511634 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
541 9 1 5 6.2 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)no3)CC2)[C@@H](c2ccccc2)C1
CHEMBL281176 ccr5_human Human No 9.1 IC50 = 0.8 nM Bind
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
516 10 1 4 6.0 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCSc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL281607 ccr5_human Human No 9.1 IC50 = 0.8 nM Bind
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
524 11 1 3 6.4 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL328260 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Ability to displace [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesAbility to displace [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
588 10 0 6 6.0 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL1926901 ccr5_human Human No 9.1 IC50 = 0.8 nM Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
584 13 1 8 5.0 COCCOc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(C#N)nc3C)CC2)cc1
CHEMBL2435864 ccr5_human Human No 9.1 IC50 = 0.8 nM Funct
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
574 9 1 5 5.4 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(Cc3ccncc3)C[C@H]2c2ccccc2)CC1
CHEMBL2435909 ccr5_human Human No 9.1 IC50 = 0.8 nM Funct
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
581 9 1 5 5.2 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(CC3CCOCC3)C[C@H]2c2ccccc2)CC1
CHEMBL2164201 ccr5_human Human No 9.1 IC50 = 0.8 nM Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
551 10 1 7 4.5 Cc1cc(C#N)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)CC2CCOCC2)CC1
CHEMBL58897 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Funct
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
473 4 1 3 5.9 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(C(F)(F)F)cc3)CC2)CC1
CHEMBL275998 ccr5_human Human No 9.1 IC50 = 0.8 nM Bind
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
553 12 1 7 4.7 CCCN(c1nccc(OC)n1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL328297 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
616 10 0 6 6.4 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)c3ccccc3Cl)C[C@@H]2c2ccccc2)CC1
CHEMBL193822 ccr5_human Human No 9.1 IC50 = 0.8 nM Bind
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
580 9 1 5 6.7 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccc(-c5ccccc5)cn34)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL172854 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
560 9 1 5 6.0 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL435538 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
560 11 1 5 6.0 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL328297 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
616 10 0 6 6.4 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)c3ccccc3Cl)C[C@@H]2c2ccccc2)CC1
CHEMBL101961 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
512 10 2 4 5.4 O=C(O)[C@@H](c1ccccc1)N1C[C@H](CN2CCC(O)(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL172854 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
560 9 1 5 6.0 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL281607 ccr5_human Human No 9.1 IC50 = 0.8 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
524 11 1 3 6.4 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL471909 ccr5_human Human No 9.1 IC50 = 0.8 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
530 11 1 4 6.4 CC(C)C[C@H](C(=O)O)N1C[C@H](CN2CCC(CCSc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL511634 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
541 9 1 5 6.2 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)no3)CC2)[C@@H](c2ccccc2)C1
CHEMBL255644 ccr5_human Human No 9.1 IC50 = 0.8 nM Bind
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
523 5 0 5 6.1 CC1(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CCN(C(=O)c2c(Cl)cncc2Cl)CC1
CHEMBL255856 ccr5_macfa Crab-eating macaque No 9.1 IC50 = 0.8 nM Bind
Displacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cellsDisplacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cells
483 5 0 5 5.4 Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1
CHEMBL101961 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
512 10 2 4 5.4 O=C(O)[C@@H](c1ccccc1)N1C[C@H](CN2CCC(O)(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL310106 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
654 14 1 6 5.7 CCCN(C(=O)OCc1cccc(C(N)=O)c1)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2cccc(Cl)c2)CC1
CHEMBL207487 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
643 10 0 6 4.7 CS(=O)(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(S(C)(=O)=O)CC3)c3ccc(Cl)c(Cl)c3)CC2)cc1
CHEMBL435709 ccr5_human Human No 9.1 IC50 = 0.8 nM Bind
Inhibitory activity against human CC chemokine receptor 5Inhibitory activity against human CC chemokine receptor 5
541 9 1 5 6.2 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3oncc3Cc3ccccc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL172013 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
630 11 1 6 6.5 CCn1nc(Cc2ccc(OC(F)(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL172327 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
658 14 1 6 7.7 CCCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C5CCCCC5)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1
CHEMBL172854 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
560 9 1 5 6.0 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL175424 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
632 13 1 6 7.2 CCCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1
CHEMBL176624 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
618 13 1 6 6.8 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC(C)C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL177168 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
632 15 1 6 7.2 CCCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1
CHEMBL177204 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
618 11 1 6 6.8 CCn1nc(Cc2ccc(OC(C)(C)C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL263787 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
604 13 1 6 6.4 CCOc1cccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)c1
CHEMBL354413 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
726 12 1 7 7.4 CCn1nc(Cc2ccc(S(=O)(=O)c3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL355809 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
618 12 1 6 6.8 CCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1
CHEMBL366492 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
601 11 1 7 5.5 CCn1nc(Cc2ccc(OC)c(C#N)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL366742 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
616 11 1 5 7.3 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C(C)(C)C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL369278 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
604 13 1 6 6.4 CCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1
CHEMBL327241 ccr5_human Human No 9.1 IC50 = 0.8 nM Bind
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
632 10 0 6 6.9 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)c3cccc4ccccc34)C[C@@H]2c2ccccc2)CC1
CHEMBL328260 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
588 10 0 6 6.0 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL328297 ccr5_human Human Yes 9.1 IC50 = 0.8 nM Bind
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
616 10 0 6 6.4 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)c3ccccc3Cl)C[C@@H]2c2ccccc2)CC1
CHEMBL435886 ccr5_human Human No 9.1 IC50 = 0.8 nM Bind
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
572 8 1 5 6.0 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccc(C(F)(F)F)cn34)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL489324 ccr5_human Human No 9.1 IC50 = 0.8 nM Bind
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
501 8 1 5 5.8 Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CCC(F)(F)CC2)c2ccccc2)CC1
CHEMBL522259 ccr5_human Human No 9.1 IC50 = 0.8 nM Bind
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
501 8 1 5 5.8 Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CCC(F)(F)CC2)c2ccccc2)CC1
CHEMBL193440 ccr5_human Human No 9.1 IC50 = 0.8 nM Bind
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
542 10 1 5 6.3 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(CCCn3cnc4ccccc43)CC2)[C@@H](c2ccccc2)C1
CHEMBL449758 ccr5_human Human No 9.1 IC50 = 0.9 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
555 11 1 5 6.4 CCc1nc(Cc2ccccc2)oc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1
CHEMBL193988 ccr5_human Human No 9.1 IC50 = 0.9 nM Bind
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
538 8 1 5 5.7 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccc(Cl)cn34)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL449758 ccr5_human Human No 9.1 IC50 = 0.9 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
555 11 1 5 6.4 CCc1nc(Cc2ccccc2)oc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1
CHEMBL2112556 ccr5_human Human Yes 9.1 IC50 = 0.9 nM Bind
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
573 11 1 5 6.5 CCc1nc(Cc2ccccc2)oc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL435727 ccr5_human Human Yes 9.1 IC50 = 0.9 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
574 12 1 5 6.4 CCC(CC)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL470510 ccr5_human Human No 9.1 IC50 = 0.9 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
562 11 1 5 5.1 CC(C)C[C@H](C(=O)O)N1C[C@H](CN2CCC(CCS(=O)(=O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL20602 ccr5_human Human No 9.1 IC50 = 0.9 nM Bind
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
548 10 1 5 4.7 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCS(=O)(=O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL2435907 ccr5_human Human No 9.1 IC50 = 0.9 nM Funct
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
551 8 1 4 5.7 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCC3)C[C@H]2c2ccccc2)CC1
CHEMBL2164218 ccr5_human Human No 9.1 IC50 = 0.9 nM Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
476 8 1 5 4.4 CC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1
CHEMBL174457 ccr5_human Human Yes 9.1 IC50 = 0.9 nM Bind
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
560 11 1 5 6.0 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL435727 ccr5_human Human Yes 9.1 IC50 = 0.9 nM Bind
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
574 12 1 5 6.4 CCC(CC)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL444497 ccr5_human Human No 9.1 IC50 = 0.9 nM Bind
Displacement of [125I]MIP-1beta from CCR5 expressed in CHO cell membraneDisplacement of [125I]MIP-1beta from CCR5 expressed in CHO cell membrane
594 8 0 6 7.0 COC(=O)C(c1ccc(F)cc1)N1CCC(CCN2[C@H]3CC[C@@H]2C[C@H](n2c(C)nc4ccccc42)C3)(c2ccccc2)CC1
CHEMBL435727 ccr5_human Human Yes 9.1 IC50 = 0.9 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
574 12 1 5 6.4 CCC(CC)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL470510 ccr5_human Human No 9.1 IC50 = 0.9 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
562 11 1 5 5.1 CC(C)C[C@H](C(=O)O)N1C[C@H](CN2CCC(CCS(=O)(=O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL255856 ccr5_human Human No 9.1 IC50 = 0.9 nM Bind
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
483 5 0 5 5.4 Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1
CHEMBL2434978 ccr5_human Human No 9.1 IC50 = 0.9 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
572 8 1 6 5.6 O=C(O)c1ccc(Sc2ccc(CN3CCC(N4C(=O)N(C5CCOCC5)C[C@H]4c4ccccc4)CC3)cn2)cc1
CHEMBL2435844 ccr5_human Human No 9.1 IC50 = 0.9 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
607 8 1 7 5.6 O=C(O)c1ccc(Sc2ncc(CN3CCC(N4C(=O)N(C5CCOCC5)C[C@H]4c4cccc(Cl)c4)CC3)cn2)cc1
CHEMBL2435845 ccr5_human Human No 9.1 IC50 = 0.9 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
604 8 2 7 5.5 Cc1nc(Nc2ccc(C(=O)O)cc2)ncc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2cccc(Cl)c2)CC1
CHEMBL2435859 ccr5_human Human No 9.1 IC50 = 0.9 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
579 9 1 4 6.4 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(CC3CCCCC3)C[C@H]2c2ccccc2)CC1
CHEMBL2435907 ccr5_human Human No 9.1 IC50 = 0.9 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
551 8 1 4 5.7 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCC3)C[C@H]2c2ccccc2)CC1
CHEMBL2435912 ccr5_human Human No 9.1 IC50 = 0.9 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
571 8 1 5 6.2 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccsc2)CC1
CHEMBL171468 ccr5_human Human Yes 9.1 IC50 = 0.9 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
585 11 1 6 5.9 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4cccc(C#N)c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL174904 ccr5_human Human Yes 9.1 IC50 = 0.9 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
615 10 1 7 5.9 CCn1nc(Cc2ccc(OC)c(C#N)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL176604 ccr5_human Human Yes 9.1 IC50 = 0.9 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
604 11 1 6 6.4 CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1
CHEMBL366600 ccr5_human Human Yes 9.1 IC50 = 0.9 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
620 10 1 5 7.2 CCn1nc(Cc2ccc(Cl)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL367102 ccr5_human Human Yes 9.1 IC50 = 0.9 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
604 13 1 6 6.4 CCOc1cccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)c1
CHEMBL368332 ccr5_human Human Yes 9.1 IC50 = 0.9 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
622 10 1 5 6.8 CCn1nc(Cc2cc(F)cc(F)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL435538 ccr5_human Human Yes 9.1 IC50 = 0.9 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
560 11 1 5 6.0 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL82301 ccr5_mouse Mouse Yes 9.0 IC50 = 0.9 nM Bind
Displacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hrDisplacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hr
533 6 0 6 4.5 COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F
CHEMBL461690 ccr5_human Human No 9.0 IC50 = 0.9 nM Bind
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
493 10 1 3 5.1 CCN(C(=O)Cc1ccc(F)cc1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1
CHEMBL3085310 ccr5_human Human No 9.0 IC50 = 1.0 nM Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
683 17 1 8 7.9 CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4nncn4CCC)cc2)CCCN3CCC)cc1
CHEMBL3109175 ccr5_human Human No 9.0 IC50 = 1.0 nM Bind
Antagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 JR-FL-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assayAntagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 JR-FL-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assay
652 18 1 6 8.8 Cc1nnc(CCCCCCCCCCN=[N+]=[N-])n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1
CHEMBL1926904 ccr5_human Human No 9.0 IC50 = 1.0 nM Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
583 12 2 8 3.8 Cc1ccncc1CN(c1ccc(OCC(N)=O)cc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(C#N)nc2C)CC1
CHEMBL317710 ccr5_human Human Yes 9.0 IC50 = 1 nM Bind
Ability to inhibit binding of [125I]-MIP-1 alpha to C-C chemokine receptor type 5 in Chinese hamster ovary (CHO) cell membranesAbility to inhibit binding of [125I]-MIP-1 alpha to C-C chemokine receptor type 5 in Chinese hamster ovary (CHO) cell membranes
474 9 1 3 6.1 OC1(CCCc2ccccc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL593042 ccr5_human Human No 9.0 IC50 = 1 nM Funct
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
547 6 0 5 3.8 Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1
CHEMBL471623 ccr5_human Human No 9.0 IC50 = 1 nM Bind
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
459 6 0 3 4.4 Cc1cccc(C)c1C(=O)N1CCC(N2CC[C@@H](N(Cc3ccccc3)C(=O)C3CC3)C2)CC1
CHEMBL481068 ccr5_human Human No 9.0 IC50 = 1 nM Bind
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
485 6 0 3 5.0 Cc1cccc(C)c1C(=O)N1[C@H]2CC[C@@H]1C[C@@H](N1CC[C@@H](N(Cc3ccccc3)C(=O)C3CC3)C1)C2
CHEMBL61424 ccr5_human Human Yes 9.0 IC50 = 1 nM Funct
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
483 5 0 5 5.4 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1
CHEMBL2113088 ccr5_human Human No 9.0 IC50 = 1 nM Bind
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
505 8 1 6 4.4 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4cnccn34)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL420465 ccr5_human Human No 9.0 IC50 = 1 nM Bind
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
556 11 2 6 5.2 OC1(CCCc2ccc(Cc3nnn[nH]3)cc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL379082 ccr5_human Human No 9.0 IC50 = 1 nM Bind
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
630 11 0 6 5.2 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cccc(Cl)c2)CC1
CHEMBL3084499 ccr5_human Human No 9.0 IC50 = 1 nM Bind
Displacement of [125I]MIP-1beta from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1beta from human CCR5 expressed in CHO cells
546 5 0 4 7.2 Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CCC1(c2cccc(Cl)c2)CCN(C(=O)C(C)(C)C)CC1
CHEMBL480890 ccr5_human Human No 9.0 IC50 = 1 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
559 11 1 5 6.7 CCc1nc(Cc2ccccc2)sc1C1CCN(C[C@H]2CN([C@H](CC(C)C)C(=O)O)C[C@@H]2c2ccccc2)CC1
CHEMBL99788 ccr5_human Human Yes 9.0 IC50 = 1 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
532 10 1 5 5.7 COC(=O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(O)(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL255645 ccr5_human Human No 9.0 IC50 = 1 nM Bind
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
539 5 0 5 5.3 CC1(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CCN(C(=O)c2c(Cl)c[n+]([O-])cc2Cl)CC1
CHEMBL61424 ccr5_human Human Yes 9.0 IC50 = 1 nM Bind
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
483 5 0 5 5.4 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1
CHEMBL103343 ccr5_human Human Yes 9.0 IC50 = 1 nM Bind
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
504 10 2 4 5.5 OC[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(O)(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL103813 ccr5_human Human Yes 9.0 IC50 = 1 nM Bind
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
504 10 2 4 5.5 OC[C@H](C1CCCCC1)N1C[C@H](CN2CCC(O)(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL99788 ccr5_human Human Yes 9.0 IC50 = 1 nM Bind
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
532 10 1 5 5.7 COC(=O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(O)(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL2435864 ccr5_human Human No 9.0 IC50 = 1 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
574 9 1 5 5.4 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(Cc3ccncc3)C[C@H]2c2ccccc2)CC1
CHEMBL2435866 ccr5_human Human No 9.0 IC50 = 1 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
617 10 2 5 5.7 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(Cc3ccc(C(=O)O)cc3)C[C@H]2c2ccccc2)CC1
CHEMBL2112555 ccr5_human Human Yes 9.0 IC50 = 1 nM Bind
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
563 10 1 5 6.4 CCc1nc(Cc2ccccc2)sc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL368183 ccr5_human Human Yes 9.0 IC50 = 1 nM Bind
Inhibition of human CX3C chemokine receptor 5 from GP120-membrane-based assayInhibition of human CX3C chemokine receptor 5 from GP120-membrane-based assay
568 10 1 5 6.1 Cn1ncc(CCc2ccccc2)c1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL204821 ccr5_human Human Yes 9.0 IC50 = 1 nM Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
682 17 1 7 8.4 CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc([S+]([O-])Cc4cncn4CCC)cc2)CCN3CC(C)C)cc1
CHEMBL93139 ccr5_human Human Yes 9.0 IC50 = 1 nM Bind
Inhibitory concentration against human C-C chemokine receptor type 5 in CHO cells with [125I]-MIP-1 alpha radioligandInhibitory concentration against human C-C chemokine receptor type 5 in CHO cells with [125I]-MIP-1 alpha radioligand
634 14 0 7 5.9 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(CC[C@](C)(CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL172079 ccr5_human Human Yes 9.0 IC50 = 1 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
630 12 1 6 7.0 CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C5CCCCC5)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1
CHEMBL172820 ccr5_human Human No 9.0 IC50 = 1 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
585 9 1 6 5.9 CCn1nc(Cc2cccc(C#N)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL176337 ccr5_human Human Yes 9.0 IC50 = 1 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
602 12 1 6 6.2 CCn1nc(Cc2ccc(OC3CC3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL177205 ccr5_human Human Yes 9.0 IC50 = 1 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
604 10 1 5 6.7 CCn1nc(Cc2cccc(F)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL367383 ccr5_human Human Yes 9.0 IC50 = 1 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
590 12 1 6 6.0 CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1
CHEMBL368309 ccr5_human Human Yes 9.0 IC50 = 1 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
632 15 1 6 7.2 CCCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1
CHEMBL1172043 ccr5_human Human No 9.0 IC50 = 1.1 nM Funct
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
579 9 1 5 5.5 C=CCN(C(=O)OCc1ccc(Cl)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1
CHEMBL1172048 ccr5_human Human No 9.0 IC50 = 1.1 nM Funct
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
612 9 2 4 5.4 C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1
CHEMBL280344 ccr5_human Human No 9.0 IC50 = 1.1 nM Bind
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
588 10 1 5 5.6 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(CCS(=O)(=O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL1688239 ccr5_human Human No 9.0 IC50 = 1.1 nM Funct
Antagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxisAntagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxis
525 3 0 5 4.5 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN(C3CCc4cc(Br)ccc43)[C@@H](C)C2)CC1
CHEMBL58387 ccr5_human Human Yes 9.0 IC50 = 1.1 nM Funct
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
482 5 0 4 6.0 Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1
CHEMBL58897 ccr5_human Human Yes 9.0 IC50 = 1.1 nM Funct
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
473 4 1 3 5.9 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(C(F)(F)F)cc3)CC2)CC1
CHEMBL137327 ccr5_human Human No 9.0 IC50 = 1.1 nM Bind
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
535 11 1 6 4.7 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(N(CC3CC3)c3ncccn3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL382435 ccr5_human Human No 9.0 IC50 = 1.1 nM Bind
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
648 11 0 6 5.4 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cc(F)cc(Cl)c2)CC1
CHEMBL1951906 ccr5_human Human No 9.0 IC50 = 1.1 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
603 11 0 6 3.8 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2ccccc2)C2CCN(S(C)(=O)=O)CC2)CC1
CHEMBL1188566 ccr5_human Human No 9.0 IC50 = 1.1 nM Bind
Displacement of [125I]MIP1-alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1-alpha from human CCR5 expressed in CHO cells
533 9 2 5 4.9 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2
CHEMBL536754 ccr5_human Human No 9.0 IC50 = 1.1 nM Bind
Displacement of [125I]MIP1-alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1-alpha from human CCR5 expressed in CHO cells
533 9 2 5 4.9 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2
CHEMBL255429 ccr5_macfa Crab-eating macaque No 9.0 IC50 = 1.1 nM Bind
Displacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cellsDisplacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cells
482 5 0 4 6.0 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1
CHEMBL58387 ccr5_macfa Crab-eating macaque Yes 9.0 IC50 = 1.1 nM Bind
Displacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cellsDisplacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cells
482 5 0 4 6.0 Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1
CHEMBL2435854 ccr5_human Human No 9.0 IC50 = 1.1 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
584 8 1 6 5.8 Cc1cccc([C@@H]2CN(C3CCOCC3)C(=O)N2C2CCN(Cc3ccc(Oc4ccc(C(=O)O)cc4)nc3C)CC2)c1
CHEMBL2435858 ccr5_human Human No 9.0 IC50 = 1.1 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
569 8 1 6 4.9 Cc1nc(Oc2ccc(C(N)=O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2ccccc2)CC1
CHEMBL2435909 ccr5_human Human No 9.0 IC50 = 1.1 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
581 9 1 5 5.2 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(CC3CCOCC3)C[C@H]2c2ccccc2)CC1
CHEMBL2112554 ccr5_human Human Yes 9.0 IC50 = 1.1 nM Bind
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
543 8 1 5 6.7 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3csc(-c4ccccc4)n3)CC2)[C@@H](c2ccccc2)C1
CHEMBL170829 ccr5_human Human Yes 9.0 IC50 = 1.1 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
564 10 1 5 5.8 CCn1nc(Cc2ccc(F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL173019 ccr5_human Human Yes 9.0 IC50 = 1.1 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
576 9 2 6 5.7 CCn1nc(Cc2ccc(O)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL173492 ccr5_human Human Yes 9.0 IC50 = 1.1 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
566 9 1 5 6.6 CCn1nc(CC2CCCCC2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL176391 ccr5_human Human Yes 9.0 IC50 = 1.1 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
582 10 1 5 5.9 CCn1nc(Cc2ccc(F)c(F)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL367489 ccr5_human Human Yes 9.0 IC50 = 1.1 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
604 10 1 5 6.7 CCn1nc(Cc2ccc(F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL367916 ccr5_human Human Yes 9.0 IC50 = 1.1 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
700 11 1 7 6.9 CCn1nc(Cc2ccc(S(=O)(=O)c3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL367988 ccr5_human Human Yes 9.0 IC50 = 1.1 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
666 12 1 6 7.6 CCn1nc(Cc2ccc(OCc3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL369040 ccr5_human Human Yes 9.0 IC50 = 1.1 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
700 13 1 7 6.9 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(S(=O)(=O)c5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL369277 ccr5_human Human Yes 9.0 IC50 = 1.1 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
618 14 1 6 6.8 CCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1
CHEMBL369632 ccr5_human Human Yes 9.0 IC50 = 1.1 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
616 11 1 6 6.6 CCn1nc(Cc2ccc(OC)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL440554 ccr5_human Human Yes 9.0 IC50 = 1.1 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
644 12 1 6 6.9 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL173095 ccr5_human Human Yes 8.9 IC50 = 1.2 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
572 11 1 5 6.2 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL175327 ccr5_human Human Yes 8.9 IC50 = 1.2 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
558 11 1 5 5.8 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@H](CC3CC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL353331 ccr5_human Human Yes 8.9 IC50 = 1.2 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
568 10 1 5 6.4 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL471542 ccr5_human Human Yes 8.9 IC50 = 1.2 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
541 9 1 5 6.2 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)on3)CC2)[C@@H](c2ccccc2)C1
CHEMBL2435862 ccr5_human Human No 8.9 IC50 = 1.2 nM Funct
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
588 9 1 5 5.7 Cc1ccncc1CN1C[C@@H](c2ccccc2)N(C2CCN(C(C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)C1=O
CHEMBL82301 ccr5_human Human Yes 8.9 IC50 = 1.2 nM Funct
Antagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxisAntagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxis
533 6 0 6 4.5 COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F
CHEMBL1688240 ccr5_human Human No 8.9 IC50 = 1.2 nM Funct
Antagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxisAntagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxis
515 3 0 5 4.8 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN(C3CCc4cc(C(F)(F)F)ccc43)[C@@H](C)C2)CC1
CHEMBL2164213 ccr5_human Human No 8.9 IC50 = 1.2 nM Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
507 10 1 7 4.8 COc1ccc(N(Cc2ccsc2)C2CCN([C@H](C)CCNC(=O)c3c(C)ncnc3C)CC2)cc1
CHEMBL342842 ccr5_human Human No 8.9 IC50 = 1.2 nM Bind
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
523 11 1 6 4.7 CCCN(c1ccncn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL343745 ccr5_human Human No 8.9 IC50 = 1.2 nM Bind
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
591 11 1 6 5.7 CCCN(c1nccc(C(F)(F)F)n1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL173095 ccr5_human Human Yes 8.9 IC50 = 1.2 nM Bind
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
572 11 1 5 6.2 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL175327 ccr5_human Human Yes 8.9 IC50 = 1.2 nM Bind
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
558 11 1 5 5.8 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@H](CC3CC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL353331 ccr5_human Human Yes 8.9 IC50 = 1.2 nM Bind
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
568 10 1 5 6.4 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL2203619 ccr5_human Human No 8.9 IC50 = 1.2 nM Bind
Displacement of [125I]MIP-1beta from CCR5 receptorDisplacement of [125I]MIP-1beta from CCR5 receptor
444 7 1 4 5.2 Cc1nc2ccccc2n1C1(C)CCN(CC[C@H](NC(=O)C2CCC2)c2ccccc2)CC1
CHEMBL173095 ccr5_human Human Yes 8.9 IC50 = 1.2 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
572 11 1 5 6.2 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL175327 ccr5_human Human Yes 8.9 IC50 = 1.2 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
558 11 1 5 5.8 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@H](CC3CC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL353331 ccr5_human Human Yes 8.9 IC50 = 1.2 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
568 10 1 5 6.4 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL471542 ccr5_human Human Yes 8.9 IC50 = 1.2 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
541 9 1 5 6.2 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)on3)CC2)[C@@H](c2ccccc2)C1
CHEMBL2435860 ccr5_human Human No 8.9 IC50 = 1.2 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
573 9 1 4 6.0 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(Cc3ccccc3)C[C@H]2c2ccccc2)CC1
CHEMBL2435885 ccr5_human Human No 8.9 IC50 = 1.2 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
565 8 1 4 6.1 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@H]2c2ccccc2)CC1
CHEMBL1271208 ccr5_human Human No 8.9 IC50 = 1.2 nM Bind
Inhibition of CCR5 by cell-cell fusion inhibition assayInhibition of CCR5 by cell-cell fusion inhibition assay
549 7 0 6 3.4 Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC(c3ccccc3)C3CCN(S(C)(=O)=O)CC3)C[C@@H]2C1
CHEMBL207182 ccr5_human Human Yes 8.9 IC50 = 1.2 nM Bind
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cellsInhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells
547 8 0 3 6.1 CC(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1
CHEMBL1178786 ccr5_human Human Yes 8.9 IC50 = 1.2 nM Funct
Inhibition of chemotactic protein to CCR5Inhibition of chemotactic protein to CCR5
495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C
CHEMBL173064 ccr5_human Human No 8.9 IC50 = 1.2 nM Bind
Inhibitory activity against human CC chemokine receptor 5Inhibitory activity against human CC chemokine receptor 5
541 9 1 5 6.2 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3nocc3Cc3ccccc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL367787 ccr5_human Human Yes 8.9 IC50 = 1.2 nM Bind
Inhibitory activity against human CC chemokine receptor 5Inhibitory activity against human CC chemokine receptor 5
554 10 2 4 6.1 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3n[nH]cc3CCc3ccccc3)CC2)[C@@H](c2ccccc2)C1
CHEMBL170118 ccr5_human Human Yes 8.9 IC50 = 1.2 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
566 11 1 5 6.6 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(CC4CCCCC4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL172806 ccr5_human Human Yes 8.9 IC50 = 1.2 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
620 11 1 7 6.0 CCn1nc(Cc2ccc(OC)c(OC)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL367697 ccr5_human Human Yes 8.9 IC50 = 1.2 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
618 14 1 6 6.8 CCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1
CHEMBL435347 ccr5_human Human Yes 8.9 IC50 = 1.2 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
590 12 1 6 6.0 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4cccc(OC)c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL353331 ccr5_human Human Yes 8.9 IC50 = 1.2 nM Bind
Inhibitory concentration to displace [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellInhibitory concentration to displace [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cell
568 10 1 5 6.4 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL353331 ccr5_human Human Yes 8.9 IC50 = 1.2 nM Bind
Inhibitory concentration to displace [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsInhibitory concentration to displace [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
568 10 1 5 6.4 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL4213499 ccr5_human Human No 8.9 IC50 = 1.3 nM Bind
Displacement of [125I]-labeled MIP-1alpha from human CCR5 expressed in CHO cell membranes after 240 mins by TopCount scintillation counting methodDisplacement of [125I]-labeled MIP-1alpha from human CCR5 expressed in CHO cell membranes after 240 mins by TopCount scintillation counting method
574 11 1 5 6.4 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@@H]2C[C@@H](N(C)[C@H](C(=O)O)C(C)C)C[C@H]2c2cccc(F)c2)CC1
CHEMBL1201187 ccr5_human Human No 8.9 IC50 = 1.3 nM Bind
Antagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 92RW-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assayAntagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 92RW-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assay
513 8 1 5 6.0 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1
CHEMBL1926902 ccr5_human Human No 8.9 IC50 = 1.3 nM Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
577 13 1 7 5.2 COCCOc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(F)nc3C)CC2)cc1
CHEMBL2435860 ccr5_human Human No 8.9 IC50 = 1.3 nM Funct
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
573 9 1 4 6.0 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(Cc3ccccc3)C[C@H]2c2ccccc2)CC1
CHEMBL489513 ccr5_human Human No 8.9 IC50 = 1.3 nM Bind
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
473 8 1 5 5.0 Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CC(F)(F)C2)c2ccccc2)CC1
CHEMBL491679 ccr5_human Human No 8.9 IC50 = 1.3 nM Bind
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
473 8 1 5 5.0 Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CC(F)(F)C2)c2ccccc2)CC1
CHEMBL481080 ccr5_human Human Yes 8.9 IC50 = 1.3 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
557 9 1 5 6.7 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3csc(Cc4ccccc4)n3)CC2)[C@@H](c2ccccc2)C1
CHEMBL401929 ccr5_human Human No 8.9 IC50 = 1.3 nM Bind
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
504 5 0 4 6.5 CC1(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CCN(C(=O)c2cccc3ccccc23)CC1
CHEMBL2435843 ccr5_human Human No 8.9 IC50 = 1.3 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
583 8 1 6 5.2 CNC(=O)c1ccc(Oc2ccc(CN3CCC(N4C(=O)N(C5CCOCC5)C[C@H]4c4ccccc4)CC3)c(C)n2)cc1
CHEMBL2435851 ccr5_human Human No 8.9 IC50 = 1.3 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
590 8 1 6 5.8 O=C(O)c1ccc(Oc2ccc(CN3CCC(N4C(=O)N(C5CCOCC5)C[C@H]4c4cccc(Cl)c4)CC3)cn2)cc1
CHEMBL481080 ccr5_human Human Yes 8.9 IC50 = 1.3 nM Bind
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
557 9 1 5 6.7 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3csc(Cc4ccccc4)n3)CC2)[C@@H](c2ccccc2)C1
CHEMBL173482 ccr5_human Human Yes 8.9 IC50 = 1.3 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
585 11 1 6 5.9 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C#N)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL176571 ccr5_human Human Yes 8.9 IC50 = 1.3 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
630 13 1 6 7.0 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC5CCC5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL176850 ccr5_human Human Yes 8.9 IC50 = 1.3 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
564 10 1 5 5.8 CCn1nc(Cc2cccc(F)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL176980 ccr5_human Human Yes 8.9 IC50 = 1.3 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
632 12 1 6 7.2 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC(C)(C)C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL177156 ccr5_human Human Yes 8.9 IC50 = 1.3 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
686 12 1 7 6.5 CCn1nc(Cc2ccc(S(=O)(=O)c3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL352511 ccr5_human Human Yes 8.9 IC50 = 1.3 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
576 11 1 6 5.6 CCn1nc(Cc2ccc(OC)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL367169 ccr5_human Human Yes 8.9 IC50 = 1.3 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
585 9 1 6 5.9 CCn1nc(Cc2ccc(C#N)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL367246 ccr5_human Human Yes 8.9 IC50 = 1.3 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
585 11 1 6 5.9 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C#N)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL369822 ccr5_human Human Yes 8.9 IC50 = 1.3 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
580 10 1 5 6.3 CCn1nc(Cc2ccc(Cl)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL1222769 ccr5_human Human No 8.9 IC50 = 1.4 nM Funct
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
630 9 2 4 5.5 C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2cccc(F)c2)CC1
CHEMBL1649912 ccr5_human Human No 8.9 IC50 = 1.4 nM Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
513 8 1 5 6.0 Cc1nc(C(C)C)n([C@@H]2C[C@@H]3CC[C@H](C2)N3CC[C@H](NC(=O)C2CCC(F)(F)CC2)c2ccccc2)n1
CHEMBL3085107 ccr5_human Human No 8.9 IC50 = 1.4 nM Bind
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
513 8 1 5 6.0 Cc1nc(C(C)C)n([C@H]2C[C@@H]3CC[C@H](C2)N3CC[C@H](NC(=O)C2CCC(F)(F)CC2)c2ccccc2)n1
CHEMBL301454 ccr5_human Human Yes 8.9 IC50 = 1.4 nM Funct
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
495 6 0 3 6.5 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1
CHEMBL1178786 ccr5_human Human Yes 8.9 IC50 = 1.4 nM Bind
Binding affinity to CCR5Binding affinity to CCR5
495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C
CHEMBL1178786 ccr5_human Human Yes 8.9 IC50 = 1.4 nM Funct
Compound was evaluated for the antagonist activity against C-C chemokine receptor type 5Compound was evaluated for the antagonist activity against C-C chemokine receptor type 5
495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C
CHEMBL1178786 ccr5_human Human Yes 8.9 IC50 = 1.4 nM Bind
Displacement of [125I]RANTES from CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from CCR5 expressed in CHO cells
495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C
CHEMBL301454 ccr5_human Human Yes 8.9 IC50 = 1.4 nM Bind
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
495 6 0 3 6.5 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1
CHEMBL1178786 ccr5_human Human Yes 8.9 IC50 = 1.4 nM Bind
Displacement of [125I]RANTES from human CCR5 expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells after 40 mins by scintillation counting analysis
495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C
CHEMBL1201187 ccr5_human Human No 8.9 IC50 = 1.4 nM Bind
Displacement of [128I]RANTES from human CCR5 receptor coexpressed with Galphai6 in CHO cells after 2 hrs by scintillation countingDisplacement of [128I]RANTES from human CCR5 receptor coexpressed with Galphai6 in CHO cells after 2 hrs by scintillation counting
513 8 1 5 6.0 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1
CHEMBL1178786 ccr5_human Human Yes 8.9 IC50 = 1.4 nM Bind
Inhibition of CCL5 binding to CCR5 expressed in CHO cellsInhibition of CCL5 binding to CCR5 expressed in CHO cells
495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C
CHEMBL1178786 ccr5_human Human Yes 8.9 IC50 = 1.4 nM Bind
Inhibition of CCR5Inhibition of CCR5
495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C
CHEMBL2435852 ccr5_human Human No 8.9 IC50 = 1.4 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
570 8 1 6 5.5 Cc1nc(Oc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2ccccc2)CC1
CHEMBL1178786 ccr5_human Human Yes 8.9 IC50 = 1.4 nM Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C
CHEMBL207630 ccr5_human Human Yes 8.9 IC50 = 1.4 nM Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
590 9 0 5 5.2 CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(C#N)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1
CHEMBL3085307 ccr5_human Human No 8.9 IC50 = 1.4 nM Funct
Inhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cellsInhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cells
682 17 1 7 8.5 CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCN3CCC)cc1
CHEMBL368375 ccr5_human Human Yes 8.9 IC50 = 1.4 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
576 11 2 6 5.7 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(O)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL1178786 ccr5_human Human Yes 8.9 IC50 = 1.4 nM Bind
Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]RANTESInhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]RANTES
495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C
CHEMBL1183361 ccr5_human Human Yes 8.9 IC50 = 1.4 nM Bind
Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]RANTESInhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]RANTES
497 6 1 3 6.2 Cc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(C[N+](C)(C)C4CCOCC4)cc2)CCO3)cc1
CHEMBL292548 ccr5_human Human Yes 8.9 IC50 = 1.4 nM Bind
Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]RANTESInhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]RANTES
497 6 1 3 6.2 Cc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(C[N+](C)(C)C4CCOCC4)cc2)CCO3)cc1
CHEMBL283788 ccr5_human Human No 8.8 IC50 = 1.5 nM Bind
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
568 12 1 5 5.7 COC(=O)C(CCC1CCN(C[C@H]2CN([C@H](CC3CC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1)c1ccc(F)cc1
CHEMBL1926894 ccr5_human Human No 8.8 IC50 = 1.5 nM Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
535 10 1 6 5.4 COc1ccc(N(Cc2cccnc2)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)cc1
CHEMBL2435885 ccr5_human Human No 8.8 IC50 = 1.5 nM Funct
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
565 8 1 4 6.1 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@H]2c2ccccc2)CC1
CHEMBL2435886 ccr5_human Human No 8.8 IC50 = 1.5 nM Funct
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
565 8 1 4 6.1 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@H]2c2ccccc2)CC1
CHEMBL1688243 ccr5_human Human Yes 8.8 IC50 = 1.5 nM Funct
Antagonist activity at CCR5 assessed as inhibition of receptor internalizationAntagonist activity at CCR5 assessed as inhibition of receptor internalization
559 5 0 6 4.8 CCO[C@@H]1Cc2cc(C(F)(F)F)ccc2[C@H]1N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C
CHEMBL343366 ccr5_human Human No 8.8 IC50 = 1.5 nM Bind
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
509 10 1 6 4.3 CCN(c1ncccn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL174304 ccr5_human Human Yes 8.8 IC50 = 1.5 nM Bind
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
546 10 1 5 5.6 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL174304 ccr5_human Human Yes 8.8 IC50 = 1.5 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
546 10 1 5 5.6 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL283788 ccr5_human Human No 8.8 IC50 = 1.5 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
568 12 1 5 5.7 COC(=O)C(CCC1CCN(C[C@H]2CN([C@H](CC3CC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1)c1ccc(F)cc1
CHEMBL481274 ccr5_human Human Yes 8.8 IC50 = 1.5 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
541 9 1 5 6.2 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3ncc(Cc4ccccc4)o3)CC2)[C@@H](c2ccccc2)C1
CHEMBL2435855 ccr5_human Human No 8.8 IC50 = 1.5 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
588 8 1 6 5.6 Cc1nc(Oc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2cccc(F)c2)CC1
CHEMBL2114183 ccr5_human Human Yes 8.8 IC50 = 1.5 nM Bind
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
622 14 0 7 5.9 CCCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(CCC(CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL421342 ccr5_human Human Yes 8.8 IC50 = 1.5 nM Bind
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
622 14 0 7 5.9 CCCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL82168 ccr5_human Human Yes 8.8 IC50 = 1.5 nM Bind
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
575 13 0 5 5.8 C=CCN(C(=O)OCc1ccccc1)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL481274 ccr5_human Human Yes 8.8 IC50 = 1.5 nM Bind
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
541 9 1 5 6.2 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3ncc(Cc4ccccc4)o3)CC2)[C@@H](c2ccccc2)C1
CHEMBL172090 ccr5_human Human Yes 8.8 IC50 = 1.5 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
620 13 1 7 6.0 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC)c(OC)c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL173202 ccr5_human Human Yes 8.8 IC50 = 1.5 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
622 10 1 5 6.8 CCn1nc(Cc2ccc(F)cc2F)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL174304 ccr5_human Human Yes 8.8 IC50 = 1.5 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
546 10 1 5 5.6 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL366494 ccr5_human Human Yes 8.8 IC50 = 1.5 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
654 10 1 5 7.6 CCn1nc(Cc2ccc(C(F)(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL368823 ccr5_human Human Yes 8.8 IC50 = 1.5 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
590 10 1 6 6.0 CCn1nc(Cc2ccc(OC)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL1179044 ccr5_human Human Yes 8.8 IC50 = 1.5 nM Bind
Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]RANTESInhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]RANTES
551 6 1 3 6.9 C[N+](C)(Cc1ccc(NC(=O)C2=Cc3cc(-c4ccc(C(F)(F)F)cc4)ccc3OCC2)cc1)C1CCOCC1
CHEMBL56565 ccr5_human Human Yes 8.8 IC50 = 1.5 nM Bind
Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]RANTESInhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]RANTES
551 6 1 3 6.9 C[N+](C)(Cc1ccc(NC(=O)C2=Cc3cc(-c4ccc(C(F)(F)F)cc4)ccc3OCC2)cc1)C1CCOCC1
CHEMBL421342 ccr5_human Human Yes 8.8 IC50 = 1.5 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
622 14 0 7 5.9 CCCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL81926 ccr5_human Human No 8.8 IC50 = 1.5 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
591 13 0 5 6.3 CCCN(C(=O)OCc1ccccc1C)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL1172625 ccr5_human Human No 8.8 IC50 = 1.5 nM Funct
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
622 11 2 6 3.2 C=CCN(C(=O)Cc1ccc(S(=O)(=O)NC)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1
CHEMBL457044 ccr5_human Human No 8.8 IC50 = 1.5 nM Bind
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
509 10 1 3 5.6 CCN(C(=O)Cc1cccc(Cl)c1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1
CHEMBL20598 ccr5_human Human No 8.8 IC50 = 1.6 nM Bind
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
540 11 2 4 5.6 CC(O)(CCC1CCN(C[C@H]2CN([C@H](CC3CC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1)c1ccc(F)cc1
CHEMBL21167 ccr5_human Human No 8.8 IC50 = 1.6 nM Bind
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
534 10 1 4 6.3 O=C(CCC1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1)c1ccc(F)cc1
CHEMBL1201187 ccr5_human Human No 8.8 IC50 = 1.6 nM Bind
Antagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 JR-FL-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assayAntagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 JR-FL-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assay
513 8 1 5 6.0 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1
CHEMBL1926897 ccr5_human Human No 8.8 IC50 = 1.6 nM Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
519 10 1 6 4.9 COc1ccc(N(Cc2cccnc2)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(F)nc3C)CC2)cc1
CHEMBL138437 ccr5_human Human Yes 8.8 IC50 = 1.6 nM Bind
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
537 10 1 6 5.0 CCCN(c1ncccn1)C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL172371 ccr5_human Human Yes 8.8 IC50 = 1.6 nM Bind
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
560 10 1 5 6.0 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@](C)(C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL352514 ccr5_human Human Yes 8.8 IC50 = 1.6 nM Bind
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
540 10 1 5 5.6 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL353330 ccr5_human Human Yes 8.8 IC50 = 1.6 nM Bind
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
586 10 1 5 6.6 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL1951898 ccr5_human Human No 8.8 IC50 = 1.6 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
658 11 0 7 3.5 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2ccccc2)N2CCN(S(=O)(=O)C(F)(F)F)CC2)CC1
CHEMBL20598 ccr5_human Human No 8.8 IC50 = 1.6 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
540 11 2 4 5.6 CC(O)(CCC1CCN(C[C@H]2CN([C@H](CC3CC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1)c1ccc(F)cc1
CHEMBL352514 ccr5_human Human Yes 8.8 IC50 = 1.6 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
540 10 1 5 5.6 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL480504 ccr5_human Human Yes 8.8 IC50 = 1.6 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
513 10 1 5 5.4 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)o3)CC2)[C@@H](c2ccccc2)C1
CHEMBL480504 ccr5_human Human Yes 8.8 IC50 = 1.6 nM Bind
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
513 10 1 5 5.4 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)o3)CC2)[C@@H](c2ccccc2)C1
CHEMBL353330 ccr5_human Human Yes 8.8 IC50 = 1.6 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
586 10 1 5 6.6 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL366328 ccr5_human Human Yes 8.8 IC50 = 1.6 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
632 12 1 6 7.2 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC(C)(C)C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL367461 ccr5_human Human Yes 8.8 IC50 = 1.6 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
638 10 1 7 5.4 CCn1nc(Cc2ccc(S(C)(=O)=O)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL368182 ccr5_human Human Yes 8.8 IC50 = 1.6 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
696 11 1 5 8.1 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4cc(C(F)(F)F)cc(C(F)(F)F)c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL1172050 ccr5_human Human No 8.8 IC50 = 1.6 nM Funct
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
580 9 2 4 4.7 C=CCN(C(=O)NCc1ccc(F)cc1F)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1
CHEMBL1172051 ccr5_human Human No 8.8 IC50 = 1.7 nM Funct
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
580 9 2 4 4.7 C=CCN(C(=O)NCc1ccc(F)c(F)c1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1
CHEMBL1288663 ccr5_human Human No 8.8 IC50 = 1.7 nM Funct
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
848 11 2 6 8.2 CC(C)(C)NS(=O)(=O)c1cc(C(=O)N2CCC(CCN3CCC(N(C(=O)NCc4ccc(C#N)cc4)c4cccc(F)c4)CC3)(c3cccc(F)c3)CC2)c(Cl)cc1F
CHEMBL335562 ccr5_human Human No 8.8 IC50 = 1.7 nM Bind
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
523 11 1 6 4.7 CCCN(c1cncnc1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL198150 ccr5_human Human No 8.8 IC50 = 1.7 nM Bind
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed in CHO cells
596 11 0 6 4.6 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC(c2ccccc2)c2ccc(S(C)(=O)=O)cc2)CC1
CHEMBL198150 ccr5_human Human No 8.8 IC50 = 1.7 nM Bind
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
596 11 0 6 4.6 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC(c2ccccc2)c2ccc(S(C)(=O)=O)cc2)CC1
CHEMBL3085307 ccr5_human Human No 8.8 IC50 = 1.7 nM Bind
Displacement of [125I]RANTES from CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from CCR5 expressed in CHO cells
682 17 1 7 8.5 CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCN3CCC)cc1
CHEMBL3085309 ccr5_human Human No 8.8 IC50 = 1.7 nM Bind
Displacement of [125I]RANTES from CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from CCR5 expressed in CHO cells
734 17 1 9 8.0 CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCN3Cc2cnn(C)c2)cc1
CHEMBL255857 ccr5_human Human No 8.8 IC50 = 1.7 nM Bind
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
533 6 0 6 4.9 Cc1nc(CN(c2ccccc2)C2CCN(C3(C)CCN(C(=O)c4c(C)cc[n+]([O-])c4C)CC3)CC2)cs1
CHEMBL2435847 ccr5_human Human No 8.8 IC50 = 1.7 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
558 5 0 5 5.4 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCC(N3C(=O)N(C4CCCCC4)C[C@H]3c3ccccc3)CC2)CC1
CHEMBL2435862 ccr5_human Human No 8.8 IC50 = 1.7 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
588 9 1 5 5.7 Cc1ccncc1CN1C[C@@H](c2ccccc2)N(C2CCN(C(C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)C1=O
CHEMBL2435906 ccr5_human Human No 8.8 IC50 = 1.7 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
537 8 1 4 5.4 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCC3)C[C@H]2c2ccccc2)CC1
CHEMBL207630 ccr5_human Human Yes 8.8 IC50 = 1.7 nM Bind
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cellsInhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells
590 9 0 5 5.2 CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(C#N)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1
CHEMBL437494 ccr5_human Human No 8.8 IC50 = 1.7 nM Bind
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cellsInhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells
565 8 0 4 6.4 CC(=O)N1CCC(C(=O)N(CCCN2CCC(Sc3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1
CHEMBL366400 ccr5_human Human Yes 8.8 IC50 = 1.7 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
571 10 1 6 5.5 CCn1nc(Cc2cccc(C#N)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL368459 ccr5_human Human Yes 8.8 IC50 = 1.7 nM Bind
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
611 10 1 6 6.4 CCn1nc(Cc2ccc(C#N)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL1172045 ccr5_human Human No 8.8 IC50 = 1.7 nM Funct
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
562 9 2 4 4.5 C=CCN(C(=O)NCc1ccc(F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1
CHEMBL428104 ccr5_human Human No 8.7 IC50 = 1.8 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
523 11 1 6 4.7 CCCN(c1ncccn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL2435859 ccr5_human Human No 8.7 IC50 = 1.8 nM Funct
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
579 9 1 4 6.4 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(CC3CCCCC3)C[C@H]2c2ccccc2)CC1
CHEMBL428104 ccr5_human Human No 8.7 IC50 = 1.8 nM Bind
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
523 11 1 6 4.7 CCCN(c1ncccn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL428104 ccr5_human Human No 8.7 IC50 = 1.8 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
523 11 1 6 4.7 CCCN(c1ncccn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL255646 ccr5_human Human No 8.7 IC50 = 1.8 nM Bind
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
499 5 0 5 4.6 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccn3)CC2)CC1
CHEMBL437494 ccr5_human Human No 8.7 IC50 = 1.8 nM Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
565 8 0 4 6.4 CC(=O)N1CCC(C(=O)N(CCCN2CCC(Sc3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1
CHEMBL1178786 ccr5_human Human Yes 8.7 IC50 = 1.8 nM Bind
Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]RANTESInhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]RANTES
495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C
CHEMBL1183370 ccr5_human Human Yes 8.7 IC50 = 1.8 nM Bind
Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]RANTESInhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]RANTES
527 8 1 4 6.3 CCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(C[N+](C)(C)C4CCOCC4)cc2)CCO3)cc1
CHEMBL293393 ccr5_human Human Yes 8.7 IC50 = 1.8 nM Bind
Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]RANTESInhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]RANTES
527 8 1 4 6.3 CCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(C[N+](C)(C)C4CCOCC4)cc2)CCO3)cc1
CHEMBL204821 ccr5_human Human Yes 8.7 IC50 = 1.9 nM Bind
Displacement of [125I]RANTES from CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from CCR5 expressed in CHO cells
682 17 1 7 8.4 CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc([S+]([O-])Cc4cncn4CCC)cc2)CCN3CC(C)C)cc1
CHEMBL2282503 ccr5_human Human No 8.7 IC50 = 2.0 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
590 13 0 6 5.2 C=CCN(C(=O)c1ccc([N+](=O)[O-])cc1)C1CCN(CCC(CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL82168 ccr5_human Human Yes 8.7 IC50 = 2.0 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
575 13 0 5 5.8 C=CCN(C(=O)OCc1ccccc1)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL83335 ccr5_human Human No 8.7 IC50 = 2.0 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
620 14 0 7 5.7 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL85086 ccr5_human Human Yes 8.7 IC50 = 2.0 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
563 12 0 5 5.6 CCN(C(=O)OCc1ccccc1)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL311532 ccr5_human Human No 8.0 IC50 = 10 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
549 11 0 5 5.5 CCN(C(=O)Oc1ccccc1)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL79667 ccr5_human Human No 8.0 IC50 = 10 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
543 14 0 5 5.6 CCCCCCN(C(=O)OC)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL592940 ccr5_human Human No 8.0 IC50 = 10 nM Funct
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
551 6 0 5 4.1 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1
CHEMBL105570 ccr5_human Human Yes 8.0 IC50 = 10 nM Bind
Binding affinity against C-C chemokine receptor type 5 stably expressed in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as the radioligandBinding affinity against C-C chemokine receptor type 5 stably expressed in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as the radioligand
581 12 0 7 6.6 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(CCC(C)(Cn2cnc3ccccc32)c2ccccc2)CC1
CHEMBL107380 ccr5_human Human No 8.0 IC50 = 10 nM Bind
Binding affinity against C-C chemokine receptor type 5 stably expressed in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as the radioligandBinding affinity against C-C chemokine receptor type 5 stably expressed in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as the radioligand
610 12 0 6 6.7 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(CCC(C)(c2ccccc2)C2c3ccccc3C(=O)N2CC)CC1
CHEMBL83338 ccr5_human Human Yes 8.0 IC50 = 10 nM Bind
Binding affinity against C-C chemokine receptor type 5 stably expressed in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as the radioligandBinding affinity against C-C chemokine receptor type 5 stably expressed in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as the radioligand
556 8 0 4 5.3 CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1
CHEMBL138645 ccr5_human Human Yes 8.0 IC50 = 10 nM Bind
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
460 8 0 4 4.8 CCCN(c1ccccn1)C1CCN(C[C@H]2CN(C(=O)C3CCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL1784400 ccr5_human Human No 8.0 IC50 = 10 nM Bind
Displacement of 125I-MIP-1beta from human CCR5 receptor after 4 hrs by scintillation countingDisplacement of 125I-MIP-1beta from human CCR5 receptor after 4 hrs by scintillation counting
550 6 0 4 6.9 Cc1nc2cc(F)ccc2n1C1CC2CCC(C1)N2CCC1(c2ccccc2)CCN(C(=O)c2ccccc2)CC1
CHEMBL445925 ccr5_human Human No 8.0 IC50 = 10 nM Bind
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
499 7 2 3 6.1 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3c[nH]c4ccccc34)CC2)[C@@H](c2ccccc2)C1
CHEMBL319689 ccr5_human Human Yes 8.0 IC50 = 10 nM Bind
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
518 10 2 4 5.8 O=C(O)c1ccc(CCCC2(O)CCN(C[C@H]3CN(CC4CCCCC4)C[C@@H]3c3ccccc3)CC2)cc1
CHEMBL138645 ccr5_human Human Yes 8.0 IC50 = 10 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
460 8 0 4 4.8 CCCN(c1ccccn1)C1CCN(C[C@H]2CN(C(=O)C3CCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL319689 ccr5_human Human Yes 8.0 IC50 = 10 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
518 10 2 4 5.8 O=C(O)c1ccc(CCCC2(O)CCN(C[C@H]3CN(CC4CCCCC4)C[C@@H]3c3ccccc3)CC2)cc1
CHEMBL1077779 ccr5_human Human No 8.0 IC50 = 10 nM Bind
Displacement of [125I]RANTES from human CCR5 receptor co-transfected with Galphai6 in CHO cellsDisplacement of [125I]RANTES from human CCR5 receptor co-transfected with Galphai6 in CHO cells
537 7 0 4 6.7 CCCCC1N(CC2CCCCC2)C(=O)OC12CCN(C1(C)CCN(C(=O)c3c(C)cccc3C)CC1)CC2
CHEMBL1078335 ccr5_human Human No 8.0 IC50 = 10 nM Bind
Displacement of [125I]RANTES from human CCR5 receptor co-transfected with Galphai6 in CHO cellsDisplacement of [125I]RANTES from human CCR5 receptor co-transfected with Galphai6 in CHO cells
554 7 0 6 5.4 CCCC[C@H]1CN(CC2CCCCO2)C(=O)OC12CCN(C1(C)CCN(C(=O)c3c(C)ccnc3C)CC1)CC2
CHEMBL1762463 ccr5_human Human No 8.0 IC50 = 10 nM Bind
Displacement of [128I]-RANTES from CCR5 expressed in HEK293F cellsDisplacement of [128I]-RANTES from CCR5 expressed in HEK293F cells
624 10 1 7 5.9 CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(C(Oc2cccc(Cl)n2)c2ccc(S(C)(=O)=O)cc2)CC1
CHEMBL311532 ccr5_human Human No 8.0 IC50 = 10 nM Bind
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
549 11 0 5 5.5 CCN(C(=O)Oc1ccccc1)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL79667 ccr5_human Human No 8.0 IC50 = 10 nM Bind
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
543 14 0 5 5.6 CCCCCCN(C(=O)OC)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL83338 ccr5_human Human Yes 8.0 IC50 = 10 nM Bind
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
556 8 0 4 5.3 CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1
CHEMBL3577948 ccr5_human Human No 8.0 IC50 = 10 nM Bind
Inhibition of [125I]MCP1-beta binding to CCR5 in human HT1080 cell membranes incubated for 4 to 6 hrsInhibition of [125I]MCP1-beta binding to CCR5 in human HT1080 cell membranes incubated for 4 to 6 hrs
491 6 1 5 5.2 CC(C)[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1CC[C@H](Nc2ncnc3ccc(C(F)(F)F)cc23)C1=O
CHEMBL83338 ccr5_human Human Yes 8.0 IC50 = 10 nM Bind
Inhibitory activity against specific binding of [125I]-MIP-1 alpha to human CCR5 receptor.Inhibitory activity against specific binding of [125I]-MIP-1 alpha to human CCR5 receptor.
556 8 0 4 5.3 CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1
CHEMBL361585 ccr5_human Human Yes 8.0 IC50 = 10 nM Bind
Inhibitory concentration against human C-C chemokine receptor type 5 in CHO cells with [125I]-MIP-1 alpha radioligandInhibitory concentration against human C-C chemokine receptor type 5 in CHO cells with [125I]-MIP-1 alpha radioligand
559 10 0 4 5.2 CN(C[C@@](C)(CCN1CCC2C(CCC(=O)N2Cc2ccccc2)C1)c1ccccc1)S(=O)(=O)c1ccccc1
CHEMBL2435891 ccr5_human Human No 8.0 IC50 = 10.4 nM Bind
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
610 8 1 5 5.6 Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2cccc(Br)c2)CC1
CHEMBL59511 ccr5_human Human Yes 8.0 IC50 = 10.8 nM Funct
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
537 6 0 5 5.0 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3cccc(C#N)c3)c3ccccc3)CC2)CC1
CHEMBL3397991 ccr5_human Human No 8.0 IC50 = 10.9 nM Funct
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
592 8 0 5 4.2 CC(=O)N1CCC(C(=O)N(CCCN2CCN(S(=O)(=O)c3ccc(F)cc3)CC2C)c2ccc(C)c(Cl)c2)CC1
CHEMBL1926888 ccr5_human Human No 8.0 IC50 = 10.9 nM Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
516 10 1 7 4.5 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)ncnc3C)CC2)cc1
CHEMBL1926888 ccr5_human Human No 8.0 IC50 = 10.9 nM Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
516 10 1 7 4.5 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)ncnc3C)CC2)cc1
CHEMBL2281968 ccr5_human Human No 8.0 IC50 = 11.0 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
612 10 3 3 8.1 CCc1cccc(CC)c1NC(=O)NCC1(O)CCC(Cc2cc(Br)ccc2OCc2ccc(Cl)cc2)CC1
CHEMBL2281966 ccr5_human Human No 7.0 IC50 = 100 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
598 8 3 3 7.9 Cc1cc(C)c(NC(=O)NCC2(O)CCC(Cc3cc(Br)ccc3OCc3ccc(Cl)cc3)CC2)c(C)c1
CHEMBL2282504 ccr5_human Human Yes 7.0 IC50 = 100 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
547 12 0 4 5.5 CCCN(C(=O)c1ccccc1)C1CCN(CCC(CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL2282507 ccr5_human Human No 7.0 IC50 = 100 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
562 12 1 4 5.2 CCN(C(=O)NCc1ccccc1)C1CCN(CCC(CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL79315 ccr5_human Human No 7.0 IC50 = 100 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
549 11 0 5 5.2 COC(=O)N(Cc1ccccc1)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL88159 ccr5_human Human Yes 7.0 IC50 = 100 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
604 9 0 4 6.1 CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1ccc(Cl)c(Cl)c1)S(=O)(=O)Cc1ccccc1
CHEMBL61465 ccr5_human Human Yes 7.0 IC50 = 100 nM Funct
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
405 4 1 3 4.9 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccccc3)CC2)CC1
CHEMBL107749 ccr5_human Human Yes 7.0 IC50 = 100 nM Bind
Binding affinity against C-C chemokine receptor type 5 stably expressed in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as the radioligandBinding affinity against C-C chemokine receptor type 5 stably expressed in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as the radioligand
568 9 2 3 6.5 CC(CCN1CCC(c2ccccc2)CC1)(CN1C(=O)N[C@H](Cc2c[nH]c3ccccc23)C1=O)c1cccc(Cl)c1
CHEMBL421356 ccr5_human Human Yes 7.0 IC50 = 100 nM Bind
Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandBinding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligand
606 8 0 5 5.6 CN(C[C@@H](CCN1CCC2(CC1)CS(=O)(=O)c1ccccc12)c1ccc(Cl)c(Cl)c1)S(=O)(=O)c1ccccc1
CHEMBL87167 ccr5_human Human Yes 7.0 IC50 = 100 nM Bind
Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandBinding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligand
582 8 0 4 5.8 CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1ccc(Cl)c(Cl)c1)S(=O)(=O)C1CCCC1
CHEMBL88644 ccr5_human Human Yes 7.0 IC50 = 100 nM Bind
Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandBinding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligand
596 8 0 4 6.2 CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1ccc(Cl)c(Cl)c1)S(=O)(=O)C1CCCCC1
CHEMBL89167 ccr5_human Human Yes 7.0 IC50 = 100 nM Bind
Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandBinding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligand
591 8 0 5 5.3 CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1ccc(Cl)c(Cl)c1)S(=O)(=O)c1cccnc1
CHEMBL183406 ccr5_human Human No 7.0 IC50 = 100 nM Bind
Binding of [125I]RANTES to membranes prepared from chinese hamster ovary (CHO) cells stably expressing recombinant human C-C chemokine receptor type 5Binding of [125I]RANTES to membranes prepared from chinese hamster ovary (CHO) cells stably expressing recombinant human C-C chemokine receptor type 5
441 8 1 2 5.5 CN(C(=O)NCc1ccccc1)C1CCN(CCC(c2ccccc2)c2ccccc2)CC1
CHEMBL1784398 ccr5_human Human No 7.0 IC50 = 100 nM Bind
Displacement of 125I-MIP-1beta from human CCR5 receptor after 4 hrs by scintillation countingDisplacement of 125I-MIP-1beta from human CCR5 receptor after 4 hrs by scintillation counting
586 6 0 4 7.5 O=C(c1ccccc1)N1CCC(CCN2C3CCC2CC(n2c(C(F)(F)F)nc4ccccc42)C3)(c2ccccc2)CC1
CHEMBL192456 ccr5_human Human No 7.0 IC50 = 100 nM Bind
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
528 7 1 6 4.8 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(n3cnc(=O)c4ccccc43)CC2)[C@@H](c2ccccc2)C1
CHEMBL103268 ccr5_human Human Yes 7.0 IC50 = 100 nM Bind
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
518 10 2 4 5.8 O=C(O)c1ccccc1CCCC1(O)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL103268 ccr5_human Human Yes 7.0 IC50 = 100 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
518 10 2 4 5.8 O=C(O)c1ccccc1CCCC1(O)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL234208 ccr5_human Human No 7.0 IC50 = 100 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 receptor expressed in HEK293 cells co-expressing CD4Displacement of [125I]MIP1alpha from human CCR5 receptor expressed in HEK293 cells co-expressing CD4
599 8 3 4 6.8 Cc1cc(C)c(NC(=O)NCC2(O)CCN(Cc3cc(Br)ccc3OCc3ccc(Cl)cc3)CC2)c(C)c1
CHEMBL271076 ccr5_human Human No 7.0 IC50 = 100 nM Bind
Displacement of [125I]MIP1beta from human recombinant CCR5 receptor expressed in CHOK1 cellsDisplacement of [125I]MIP1beta from human recombinant CCR5 receptor expressed in CHOK1 cells
520 8 1 5 6.7 Cc1nnc(C(C)C)n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CCCN(C(=O)Nc1ccccc1Cl)c1ccccc1
CHEMBL1077988 ccr5_human Human No 7.0 IC50 = 100 nM Bind
Displacement of [125I]RANTES from human CCR5 receptor co-transfected with Galphai6 in CHO cellsDisplacement of [125I]RANTES from human CCR5 receptor co-transfected with Galphai6 in CHO cells
509 7 0 4 6.0 CCCCC1N(CC2CCCCC2)C(=O)OC12CCN(C1CCN(C(=O)c3ccccc3C)CC1)CC2
CHEMBL1078141 ccr5_human Human No 7.0 IC50 = 100 nM Bind
Displacement of [125I]RANTES from human CCR5 receptor co-transfected with Galphai6 in CHO cellsDisplacement of [125I]RANTES from human CCR5 receptor co-transfected with Galphai6 in CHO cells
555 7 0 7 4.6 CCCC[C@@H]1CN(CC2CCOCC2)C(=O)OC12CCN(C1(C)CCN(C(=O)c3c(C)ncnc3C)CC1)CC2
CHEMBL1762317 ccr5_human Human No 7.0 IC50 = 100 nM Bind
Displacement of [128I]-RANTES from CCR5 expressed in HEK293F cellsDisplacement of [128I]-RANTES from CCR5 expressed in HEK293F cells
604 9 1 5 7.3 CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(C(Oc2ccccc2C#N)c2ccc(C(F)(F)F)cc2)CC1
CHEMBL309922 ccr5_human Human Yes 7.0 IC50 = 100 nM Bind
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
534 11 2 4 4.4 CN(CC(CCN1CCC(NC(=O)NCc2ccccc2)CC1)c1ccccc1)S(=O)(=O)c1ccccc1
CHEMBL79315 ccr5_human Human No 7.0 IC50 = 100 nM Bind
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
549 11 0 5 5.2 COC(=O)N(Cc1ccccc1)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL79566 ccr5_human Human Yes 7.0 IC50 = 100 nM Bind
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
538 8 1 4 5.6 CN(C[C@@H](CCN1CCC2(CC1)CC(O)c1ccccc12)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1
CHEMBL82879 ccr5_human Human No 7.0 IC50 = 100 nM Bind
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
547 12 0 4 5.5 CCCN(C(=O)c1ccccc1)C1CCN(CC[C@@H](CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL83745 ccr5_human Human Yes 7.0 IC50 = 100 nM Bind
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
551 8 0 4 5.2 CN1C(=O)c2ccccc2C12CCN(CC[C@H](CN(C)S(=O)(=O)c1ccccc1)c1cccc(Cl)c1)CC2
CHEMBL137072 ccr5_human Human Yes 7.0 IC50 = 100 nM Funct
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
488 8 0 4 5.6 CCCN(c1ccccn1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL275998 ccr5_human Human No 7.0 IC50 = 100 nM Funct
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
553 12 1 7 4.7 CCCN(c1nccc(OC)n1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL343160 ccr5_human Human Yes 7.0 IC50 = 100 nM Funct
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
518 10 1 5 5.5 CCCN(c1ccccn1)C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL343366 ccr5_human Human No 7.0 IC50 = 100 nM Funct
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
509 10 1 6 4.3 CCN(c1ncccn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL344641 ccr5_human Human No 7.0 IC50 = 100 nM Funct
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
591 11 1 6 5.7 CCCN(c1ncc(C(F)(F)F)cn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL421356 ccr5_human Human Yes 7.0 IC50 = 100 nM Bind
Inhibitory activity against specific binding of [125I]-MIP-1 alpha to human CCR5 receptor.Inhibitory activity against specific binding of [125I]-MIP-1 alpha to human CCR5 receptor.
606 8 0 5 5.6 CN(C[C@@H](CCN1CCC2(CC1)CS(=O)(=O)c1ccccc12)c1ccc(Cl)c(Cl)c1)S(=O)(=O)c1ccccc1
CHEMBL89715 ccr5_human Human Yes 7.0 IC50 = 100 nM Bind
Inhibitory activity against specific binding of [125I]-MIP-1 alpha to human CCR5 receptor.Inhibitory activity against specific binding of [125I]-MIP-1 alpha to human CCR5 receptor.
480 9 0 3 5.5 CN(CC(CCN1CCC(c2ccccc2)CC1)c1cccc(F)c1)S(=O)(=O)c1ccccc1
CHEMBL90747 ccr5_human Human Yes 7.0 IC50 = 100 nM Bind
Inhibitory activity against specific binding of [125I]-MIP-1 alpha to human CCR5 receptor.Inhibitory activity against specific binding of [125I]-MIP-1 alpha to human CCR5 receptor.
528 8 0 5 4.7 CN(CC(CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1ccsc1)S(=O)(=O)c1ccccc1
CHEMBL91522 ccr5_human Human Yes 7.0 IC50 = 100 nM Bind
Inhibitory activity against specific binding of [125I]-MIP-1 alpha to human CCR5 receptor.Inhibitory activity against specific binding of [125I]-MIP-1 alpha to human CCR5 receptor.
468 9 0 4 5.4 CN(CC(CCN1CCC(c2ccccc2)CC1)c1ccsc1)S(=O)(=O)c1ccccc1
CHEMBL21058 ccr5_human Human No 6.0 IC50 = 1000 nM Bind
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
542 11 2 4 4.8 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCP(=O)(O)c3ccccc3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL2259881 ccr5_human Human No 6.0 IC50 = 1000 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
641 8 0 5 6.5 CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1ccc(Cl)c(Cl)c1)S(=O)(=O)c1cncc2ccccc12
CHEMBL2259882 ccr5_human Human No 6.0 IC50 = 1000 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
504 8 0 6 3.2 C/C=C(\C)[C@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)CN(C)S(=O)(=O)c1cn(C)cn1
CHEMBL2281892 ccr5_human Human No 6.0 IC50 = 1000 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
425 4 0 3 4.6 Brc1ccc(COc2ccc(Br)cc2N2CCOCC2)cc1
CHEMBL2282508 ccr5_human Human No 6.0 IC50 = 1000 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
500 11 1 4 4.0 CCCN(C(=O)NC)C1CCN(CCC(CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL310369 ccr5_human Human No 6.0 IC50 = 1000 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
459 9 1 5 3.3 COC(=O)NC1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL330570 ccr5_human Human Yes 6.0 IC50 = 1000 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
666 9 0 4 7.6 CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1ccc(Cl)c(Cl)c1)S(=O)(=O)c1ccc(-c2ccccc2)cc1
CHEMBL391379 ccr5_human Human Yes 6.0 IC50 = 1000 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
395 5 0 3 4.5 Clc1ccc(COc2ccc(Br)cc2CN2CCOCC2)cc1
CHEMBL421527 ccr5_human Human No 6.0 IC50 = 1000 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
501 9 1 5 4.5 CN(C[C@@H](CCN1CCC(NC(=O)OC(C)(C)C)CC1)c1ccccc1)S(=O)(=O)c1ccccc1
CHEMBL431795 ccr5_human Human Yes 6.0 IC50 = 1000 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
526 10 0 4 6.0 COc1ccccc1C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2cccc(Cl)c2)CC1
CHEMBL83107 ccr5_human Human Yes 6.0 IC50 = 1000 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
572 8 0 5 5.0 CN(C[C@@H](CCN1CCC2(CC1)CS(=O)(=O)c1ccccc12)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1
CHEMBL88344 ccr5_human Human Yes 6.0 IC50 = 1000 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
624 8 0 4 6.6 CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1ccc(Cl)c(Cl)c1)S(=O)(=O)c1cccc(Cl)c1
CHEMBL595570 ccr5_human Human No 6.0 IC50 = 1000 nM Funct
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
551 7 1 6 3.2 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)(C)CO)CC3)C[C@@H]2C1
CHEMBL327703 ccr5_human Human Yes 6.0 IC50 = 1000 nM Bind
Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandBinding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligand
556 8 0 4 6.4 CN(Cc1ccccc1)C[C@@H](CCN1CCC2(CC1)CS(=O)(=O)c1ccccc12)c1ccc(Cl)c(Cl)c1
CHEMBL420057 ccr5_human Human Yes 6.0 IC50 = 1000 nM Bind
Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandBinding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligand
574 8 0 4 6.9 CN(C[C@@H](CCN1CCC2(CC1)CSc1ccccc12)c1ccc(Cl)c(Cl)c1)S(=O)(=O)c1ccccc1
CHEMBL397647 ccr5_human Human No 6.0 IC50 = 1000 nM Bind
Displacement of MIP1-alpha from CCR5 receptorDisplacement of MIP1-alpha from CCR5 receptor
407 5 1 2 5.0 C[N+](C)(Cc1ccc(NC(=O)c2ccc(Cl)c(Cl)c2)cc1)C1CCOCC1
CHEMBL1910166 ccr5_human Human No 6.0 IC50 = 1000 nM Bind
Displacement of [125I]-MIP-1- alpha from CCR5 expressed in CHO K1 cells by scintillation proximity assayDisplacement of [125I]-MIP-1- alpha from CCR5 expressed in CHO K1 cells by scintillation proximity assay
409 9 1 4 3.7 N#Cc1cccc(C(=O)NCCCN2CCC(COCc3ccc(F)cc3)CC2)c1
CHEMBL1186558 ccr5_human Human Yes 6.0 IC50 = 1000 nM Bind
Displacement of [125I]-gp120 from human CCR5Displacement of [125I]-gp120 from human CCR5
424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2
CHEMBL2057533 ccr5_human Human Yes 6.0 IC50 = 1000 nM Bind
Displacement of [125I]-gp120 from human CCR5Displacement of [125I]-gp120 from human CCR5
424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2
CHEMBL469649 ccr5_human Human Yes 6.0 IC50 = 1000 nM Bind
Displacement of [125I]-gp120 from human CCR5Displacement of [125I]-gp120 from human CCR5
424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2
CHEMBL503631 ccr5_human Human No 6.0 IC50 = 1000 nM Bind
Displacement of [125I]MIP-1beta from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1beta from human CCR5 expressed in CHO cells
604 8 1 4 6.3 O=C1CCC(CCCN2CCC3(CC2)C(=O)NCN3c2ccccc2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1
CHEMBL391379 ccr5_human Human Yes 6.0 IC50 = 1000 nM Bind
Displacement of [125I]MIP1-alpha from human CCR5/CD4 expressed in HEK293 cellsDisplacement of [125I]MIP1-alpha from human CCR5/CD4 expressed in HEK293 cells
395 5 0 3 4.5 Clc1ccc(COc2ccc(Br)cc2CN2CCOCC2)cc1
CHEMBL391379 ccr5_human Human Yes 6.0 IC50 = 1000 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 receptor expressed in HEK293 cells co-expressing CD4Displacement of [125I]MIP1alpha from human CCR5 receptor expressed in HEK293 cells co-expressing CD4
395 5 0 3 4.5 Clc1ccc(COc2ccc(Br)cc2CN2CCOCC2)cc1
CHEMBL1186558 ccr5_human Human Yes 6.0 IC50 = 1000 nM Bind
Displacement of [125I]gp-120 from human CCR5 receptor expressed in CHO cellsDisplacement of [125I]gp-120 from human CCR5 receptor expressed in CHO cells
424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2
CHEMBL2057533 ccr5_human Human Yes 6.0 IC50 = 1000 nM Bind
Displacement of [125I]gp-120 from human CCR5 receptor expressed in CHO cellsDisplacement of [125I]gp-120 from human CCR5 receptor expressed in CHO cells
424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2
CHEMBL469649 ccr5_human Human Yes 6.0 IC50 = 1000 nM Bind
Displacement of [125I]gp-120 from human CCR5 receptor expressed in CHO cellsDisplacement of [125I]gp-120 from human CCR5 receptor expressed in CHO cells
424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2
CHEMBL1683066 ccr5_human Human No 6.0 IC50 = 1000 nM Bind
Displacement of labeled MIP-1beta from human CCR5 receptorDisplacement of labeled MIP-1beta from human CCR5 receptor
495 6 1 4 5.0 CC[C@@H]1COCC[C@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cccc(C(F)(F)F)c3)CC2)(C(C)C)C1
CHEMBL195433 ccr5_human Human Yes 6.0 IC50 = 1000 nM Bind
Inhibition of C-C chemokine receptor type 5Inhibition of C-C chemokine receptor type 5
486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C
CHEMBL363840 ccr5_human Human No 6.0 IC50 = 1000 nM Bind
Inhibition of C-C chemokine receptor type 5Inhibition of C-C chemokine receptor type 5
505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1
CHEMBL2114185 ccr5_human Human No 6.0 IC50 = 1000 nM Bind
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
471 9 0 5 3.4 CN(C[C@@H](CCN1CCC(N2CCOC2=O)CC1)c1ccccc1)S(=O)(=O)c1ccccc1
CHEMBL421527 ccr5_human Human No 6.0 IC50 = 1000 nM Bind
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
501 9 1 5 4.5 CN(C[C@@H](CCN1CCC(NC(=O)OC(C)(C)C)CC1)c1ccccc1)S(=O)(=O)c1ccccc1
CHEMBL83773 ccr5_human Human Yes 6.0 IC50 = 1000 nM Bind
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
458 9 2 4 2.9 CNC(=O)NC1CCN(CCC(CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL420057 ccr5_human Human Yes 6.0 IC50 = 1000 nM Bind
Inhibitory activity against specific binding of [125I]-MIP-1 alpha to human CCR5 receptor.Inhibitory activity against specific binding of [125I]-MIP-1 alpha to human CCR5 receptor.
574 8 0 4 6.9 CN(C[C@@H](CCN1CCC2(CC1)CSc1ccccc12)c1ccc(Cl)c(Cl)c1)S(=O)(=O)c1ccccc1
CHEMBL1170529 ccr5_human Human No 5.0 IC50 = 10000 nM Funct
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated GTPgammaS binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated GTPgammaS binding by scintillation proximity assay
516 9 1 4 5.6 COC(=O)C1(Cc2ccccc2)CCN(CC[C@H](NC(=O)C2CCC2)c2ccc(C(F)(F)F)cc2)CC1
CHEMBL3084746 ccr5_human Human No 5.0 IC50 = 10000 nM Funct
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated GTPgammaS binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated GTPgammaS binding by scintillation proximity assay
547 7 1 5 6.8 Cc1nc2cccnc2n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)c1ccc(F)cc1)c1cccc2ccccc12
CHEMBL1817911 ccr5_human Human No 5.0 IC50 = 10000 nM Funct
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
438 16 0 0 9.5 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2
CHEMBL1852138 ccr5_human Human No 5.0 IC50 = 10000 nM Funct
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
438 16 0 0 9.5 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2
CHEMBL2057814 ccr5_human Human No 5.0 IC50 = 10000 nM Funct
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
438 16 0 0 9.5 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2
CHEMBL1817911 ccr5_human Human No 5.0 IC50 = 10000 nM Funct
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
438 16 0 0 9.5 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2
CHEMBL1852138 ccr5_human Human No 5.0 IC50 = 10000 nM Funct
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
438 16 0 0 9.5 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2
CHEMBL2057814 ccr5_human Human No 5.0 IC50 = 10000 nM Funct
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
438 16 0 0 9.5 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2
CHEMBL312701 ccr5_human Human Yes 5.0 IC50 = 10000 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
496 9 0 3 6.0 CN(C[C@@H](CCN1CCC(c2ccccc2)CC1)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1
CHEMBL1198032 ccr5_human Human No 5.0 IC50 = 10000 nM Funct
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
531 10 1 4 6.0 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccccc3)c1)CC2
CHEMBL593605 ccr5_human Human No 5.0 IC50 = 10000 nM Funct
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
531 10 1 4 6.0 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccccc3)c1)CC2
CHEMBL421168 ccr5_human Human Yes 5.0 IC50 = 10000 nM Bind
Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandBinding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligand
588 9 0 4 7.3 CCN(C[C@@H](CCN1CCC2(CC1)CSc1ccccc12)c1ccc(Cl)c(Cl)c1)S(=O)(=O)c1ccccc1
CHEMBL363999 ccr5_human Human No 5.0 IC50 = 10000 nM Funct
Inhibition of MIP-1alpha ligand of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assayInhibition of MIP-1alpha ligand of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assay
386 7 2 7 1.8 CC(OC(=O)/C=C/c1ccc(O)cc1)C(=O)[C@H]1C[C@@H]1[C@H](O)[C@H]1CC=CC(=O)O1
CHEMBL1817911 ccr5_human Human No 5.0 IC50 = 10010 nM Funct
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
438 16 0 0 9.5 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2
CHEMBL1852138 ccr5_human Human No 5.0 IC50 = 10010 nM Funct
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
438 16 0 0 9.5 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2
CHEMBL2057814 ccr5_human Human No 5.0 IC50 = 10010 nM Funct
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
438 16 0 0 9.5 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2
CHEMBL233635 ccr5_human Human No 5.0 IC50 = 10092.5 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
429 7 0 2 6.3 CN(Cc1ccccc1)Cc1cc(Br)ccc1OCc1ccc(Cl)cc1
CHEMBL2057812 ccr5_human Human No 5.0 IC50 = 10100 nM Funct
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2
CHEMBL2078840 ccr5_human Human No 5.0 IC50 = 10100 nM Funct
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2
CHEMBL2057812 ccr5_human Human No 5.0 IC50 = 10100 nM Funct
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2
CHEMBL2078840 ccr5_human Human No 5.0 IC50 = 10100 nM Funct
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2
CHEMBL233635 ccr5_human Human No 5.0 IC50 = 10100 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 receptor expressed in HEK293 cells co-expressing CD4Displacement of [125I]MIP1alpha from human CCR5 receptor expressed in HEK293 cells co-expressing CD4
429 7 0 2 6.3 CN(Cc1ccccc1)Cc1cc(Br)ccc1OCc1ccc(Cl)cc1
CHEMBL596299 ccr5_human Human No 7.0 IC50 = 102 nM Funct
Antagonist activity at human CCR5Antagonist activity at human CCR5
521 6 0 5 3.8 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)C)CC3)C[C@@H]2C1
CHEMBL459985 ccr5_human Human No 7.0 IC50 = 102 nM Bind
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
468 6 0 4 4.7 Cc1ccnc(C)c1C(=O)N1CC(N(C)C2CCN(C(c3ccccc3)c3ccccc3)CC2)C1
CHEMBL294271 ccr5_human Human Yes 7.0 IC50 = 102 nM Funct
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
458 4 1 4 5.4 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3cccc4ccn(C)c34)CC2)CC1
CHEMBL293900 ccr5_human Human Yes 7.0 IC50 = 102 nM Funct
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
492 5 1 3 6.5 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2cccc3[nH]ccc23)CC1
CHEMBL449125 ccr5_human Human No 6.0 IC50 = 1023.3 nM Bind
Displacement of [125I]MIP-1beta from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1beta from human CCR5 expressed in CHO cells
590 8 1 4 5.9 O=C1CC(CCCN2CCC3(CC2)C(=O)NCN3c2ccccc2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1
CHEMBL3263023 ccr5_human Human No 5.0 IC50 = 10300 nM Funct
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
431 7 1 6 3.8 CC(C)Oc1ccc(N2CCN(Cc3ccccc3)CC2)cc1NC(=O)c1cnccn1
CHEMBL465106 ccr5_human Human No 7.0 IC50 = 104 nM Bind
Antagonist activity at CCR5 receptor by radiolabeled RANTES binding assayAntagonist activity at CCR5 receptor by radiolabeled RANTES binding assay
539 4 0 6 3.6 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCC3(CC2)CCN(S(C)(=O)=O)CC3c2ccccc2)CC1
CHEMBL120204 ccr5_human Human Yes 5.0 IC50 = 10400 nM Bind
Concentration required to inhibit [125I]-MIP-1 alpha binding to C-C chemokine receptor type 5Concentration required to inhibit [125I]-MIP-1 alpha binding to C-C chemokine receptor type 5
619 14 0 7 6.6 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(CC[C@H](C[C@H](C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1
CHEMBL372640 ccr5_human Human No 7.0 IC50 = 105 nM Bind
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed in CHO cells
551 10 1 5 4.9 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC(c2ccc(N)cc2)c2cccc(F)c2)CC1
CHEMBL171911 ccr5_human Human Yes 7.0 IC50 = 105 nM Bind
Inhibitory activity against human CX3C chemokine receptor 5 when co-administered with compound 8gInhibitory activity against human CX3C chemokine receptor 5 when co-administered with compound 8g
582 11 1 5 6.6 CCc1cc(CCc2ccccc2)nn1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL1762468 ccr5_human Human No 6.0 IC50 = 1050 nM Bind
Displacement of [128I]-RANTES from CCR5 expressed in HEK293F cellsDisplacement of [128I]-RANTES from CCR5 expressed in HEK293F cells
638 10 1 7 6.6 COC(=O)c1cccc(OC(c2ccc(C(F)(F)F)cc2)C2CCN(C(C)CCNC(=O)c3c(Cl)cncc3Cl)CC2)n1
CHEMBL2064266 ccr5_human Human No 5.0 IC50 = 10500 nM Funct
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
288 9 0 0 5.2 CCCCCCCCCCc1c(C)cc(C)[n+]2c1CCC2
CHEMBL2078746 ccr5_human Human No 5.0 IC50 = 10500 nM Funct
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
288 9 0 0 5.2 CCCCCCCCCCc1c(C)cc(C)[n+]2c1CCC2
CHEMBL255857 ccr5_macfa Crab-eating macaque No 7.0 IC50 = 107 nM Bind
Displacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cellsDisplacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cells
533 6 0 6 4.9 Cc1nc(CN(c2ccccc2)C2CCN(C3(C)CCN(C(=O)c4c(C)cc[n+]([O-])c4C)CC3)CC2)cs1
CHEMBL1683060 ccr5_human Human No 7.0 IC50 = 108 nM Bind
Displacement of labeled MIP-1beta from human CCR5 receptorDisplacement of labeled MIP-1beta from human CCR5 receptor
481 5 1 4 4.6 CC(C)[C@]1(C(=O)N2CCN(c3cccc(C(F)(F)F)c3)CC2)CC[C@@H](N[C@@H]2CCOC[C@@H]2C)C1
CHEMBL233385 ccr5_human Human Yes 6.0 IC50 = 1099.0 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
353 6 1 2 4.8 CCNCc1cc(Br)ccc1OCc1ccc(Cl)cc1
CHEMBL237896 ccr5_human Human No 6.0 IC50 = 1099.0 nM Bind
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
522 7 2 5 4.5 OC1CCN(CC2(O)CCN(Cc3cc(Br)ccc3OCc3ccc(Cl)cc3)CC2)CC1
CHEMBL350763 ccr5_human Human No 8.0 IC50 = 11 nM Bind
Ability to displace [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesAbility to displace [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
480 8 0 3 6.9 c1ccc(CCCC2CCN(C[C@@H]3[C@@H](c4ccccc4)CN4O[C@H](c5ccccc5)C[C@@H]34)CC2)cc1
CHEMBL1926878 ccr5_human Human No 8.0 IC50 = 11 nM Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
646 12 2 6 7.6 CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2ccccc2)c2ccc(Oc3ccc(C(=O)O)cc3)cc2)CC1
CHEMBL1171029 ccr5_human Human No 8.0 IC50 = 11 nM Funct
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
547 9 1 4 4.4 C=CCN(C(=O)Cc1ccc(F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1
CHEMBL1288924 ccr5_human Human No 8.0 IC50 = 11 nM Funct
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
810 13 2 6 7.6 CCCCN(C(=O)NCc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1
CHEMBL502927 ccr5_human Human No 8.0 IC50 = 11 nM Bind
Antagonist activity at CCR5 receptor by radiolabeled RANTES binding assayAntagonist activity at CCR5 receptor by radiolabeled RANTES binding assay
590 7 0 7 3.3 CCCCC1CN(S(=O)(=O)N2CCOCC2)CCC12CCN(C1(C)CCN(C(=O)c3c(C)ncnc3C)CC1)CC2
CHEMBL1096447 ccr5_human Human No 8.0 IC50 = 11 nM Bind
Binding affinity at CCR5 receptor by radiolabeled RANTES binding assayBinding affinity at CCR5 receptor by radiolabeled RANTES binding assay
447 7 1 3 4.2 Cc1cccc(C)c1C(=O)N1C[C@@H]2CN(CC[C@H](NC(=O)C(C)C)c3ccccc3)C[C@@H]2C1
CHEMBL372733 ccr5_human Human No 8.0 IC50 = 11 nM Bind
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed in CHO cells
687 14 1 6 6.1 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC(c2ccccc2)c2ccc(NS(=O)(=O)Cc3ccccc3)cc2)CC1
CHEMBL492960 ccr5_human Human No 8.0 IC50 = 11 nM Bind
Displacement of [125I]MIP-1beta from CCR5 expressed in CHO cell membraneDisplacement of [125I]MIP-1beta from CCR5 expressed in CHO cell membrane
509 5 1 5 5.0 CN/C(=N/C#N)N1CCC(CCN2[C@H]3CC[C@@H]2C[C@H](n2c(C)nc4ccccc42)C3)(c2ccccc2)CC1
CHEMBL1196449 ccr5_human Human No 8.0 IC50 = 11 nM Bind
Displacement of [125I]MIP1-alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1-alpha from human CCR5 expressed in CHO cells
477 9 1 4 5.0 CCCCN1C(=O)[C@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2
CHEMBL556995 ccr5_human Human No 8.0 IC50 = 11 nM Bind
Displacement of [125I]MIP1-alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1-alpha from human CCR5 expressed in CHO cells
477 9 1 4 5.0 CCCCN1C(=O)[C@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2
CHEMBL233847 ccr5_human Human No 8.0 IC50 = 11 nM Bind
Displacement of [125I]MIP1alpha from human CCR5 receptor expressed in HEK293 cells co-expressing CD4Displacement of [125I]MIP1alpha from human CCR5 receptor expressed in HEK293 cells co-expressing CD4
613 10 3 4 7.0 CCc1cccc(CC)c1NC(=O)NCC1(O)CCN(Cc2cc(Br)ccc2OCc2ccc(Cl)cc2)CC1
CHEMBL1270693 ccr5_human Human No 8.0 IC50 = 11 nM Bind
Inhibition of CCR5 by cell-cell fusion inhibition assayInhibition of CCR5 by cell-cell fusion inhibition assay
529 8 0 5 4.4 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC(c3cccc(F)c3)C3CCN(CC(F)F)CC3)C[C@@H]2C1
CHEMBL205964 ccr5_human Human No 8.0 IC50 = 11 nM Bind
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cellsInhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells
664 10 1 5 5.9 CC(C)(C)NC(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(S(C)(=O)=O)CC3)c3ccc(Cl)c(Cl)c3)CC2)cc1
CHEMBL1190106 ccr5_human Human No 8.0 IC50 = 11 nM Bind
Inhibition of radio-isotope labeled MIP1-alpha binding to human recombinant CCR5Inhibition of radio-isotope labeled MIP1-alpha binding to human recombinant CCR5
481 10 1 4 4.7 C=CCOc1ccc(CN2CCC3(CC2)C(=O)NC(CC2CCCCC2)C(=O)N3CCCC)cc1
CHEMBL540108 ccr5_human Human No 8.0 IC50 = 11 nM Bind
Inhibition of radio-isotope labeled MIP1-alpha binding to human recombinant CCR5Inhibition of radio-isotope labeled MIP1-alpha binding to human recombinant CCR5
481 10 1 4 4.7 C=CCOc1ccc(CN2CCC3(CC2)C(=O)NC(CC2CCCCC2)C(=O)N3CCCC)cc1
CHEMBL137327 ccr5_human Human No 8.0 IC50 = 11 nM Funct
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
535 11 1 6 4.7 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(N(CC3CC3)c3ncccn3)CC2)[C@@H](c2cccc(F)c2)C1
CHEMBL137419 ccr5_human Human Yes 8.0 IC50 = 11 nM Funct
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
486 8 0 4 5.4 C=CCN(c1ccccn1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1
CHEMBL335562 ccr5_human Human No 8.0 IC50 = 11 nM Funct
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
523 11 1 6 4.7 CCCN(c1cncnc1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL428104 ccr5_human Human No 8.0 IC50 = 11 nM Funct
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
523 11 1 6 4.7 CCCN(c1ncccn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1
CHEMBL433980 ccr5_human Human No 8.0 IC50 =