Ligand source activities (1 row/activity)
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
74265 | 210806 | None | 69 | Human | Functional | pEC50 | = | 6 | 6.0 | -2 | 3 | ChEMBL | 236 | 0 | 0 | 2 | 4.0 | Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C | 10.1021/jm301121j | |||
CHEMBL99384 | 210806 | None | 69 | Human | Functional | pEC50 | = | 6 | 6.0 | -2 | 3 | ChEMBL | 236 | 0 | 0 | 2 | 4.0 | Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C | 10.1021/jm301121j | |||
14434082 | 83816 | None | 16 | Human | Functional | pEC50 | = | 5 | 5.0 | -1 | 3 | ChEMBL | 236 | 2 | 0 | 4 | 2.4 | O=Cc1ccnc2c1ccc1c(C=O)ccnc12 | 10.1021/jm301121j | |||
CHEMBL2205801 | 83816 | None | 16 | Human | Functional | pEC50 | = | 5 | 5.0 | -1 | 3 | ChEMBL | 236 | 2 | 0 | 4 | 2.4 | O=Cc1ccnc2c1ccc1c(C=O)ccnc12 | 10.1021/jm301121j | |||
16726107 | 83522 | None | 2 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 475 | 7 | 1 | 6 | 4.4 | Cc1ccc(CN2CCC(CNC(=O)C3CCN(c4ccc(-c5cccs5)nn4)CC3)C2)cc1 | 10.1021/jm061389p | |||
CHEMBL220199 | 83522 | None | 2 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 475 | 7 | 1 | 6 | 4.4 | Cc1ccc(CN2CCC(CNC(=O)C3CCN(c4ccc(-c5cccs5)nn4)CC3)C2)cc1 | 10.1021/jm061389p | |||
14338 | 4369 | None | 74 | Human | Functional | pEC50 | = | 5.0 | 5.0 | -3 | 3 | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccnc(-c2cc(C)ccn2)c1 | 10.1021/jm301121j | |||
CHEMBL101165 | 4369 | None | 74 | Human | Functional | pEC50 | = | 5.0 | 5.0 | -3 | 3 | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccnc(-c2cc(C)ccn2)c1 | 10.1021/jm301121j | |||
14338 | 4369 | None | 74 | Human | Functional | pEC50 | = | 4.9 | 4.9 | -3 | 3 | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccnc(-c2cc(C)ccn2)c1 | 10.1021/jm301121j | |||
CHEMBL101165 | 4369 | None | 74 | Human | Functional | pEC50 | = | 4.9 | 4.9 | -3 | 3 | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccnc(-c2cc(C)ccn2)c1 | 10.1021/jm301121j | |||
16301115 | 83467 | None | 2 | Human | Functional | pEC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 435 | 7 | 1 | 6 | 3.8 | Cc1ccc(-n2c(C)nnc2SCC(=O)NC2CCN(Cc3ccccc3)CC2)cc1 | 10.1021/jm061389p | |||
CHEMBL219769 | 83467 | None | 2 | Human | Functional | pEC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 435 | 7 | 1 | 6 | 3.8 | Cc1ccc(-n2c(C)nnc2SCC(=O)NC2CCN(Cc3ccccc3)CC2)cc1 | 10.1021/jm061389p | |||
93149 | 107257 | None | 55 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -16 | 3 | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1ccnc2c1ccc1cccnc12 | 10.1021/jm301121j | |||
CHEMBL316589 | 107257 | None | 55 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -16 | 3 | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1ccnc2c1ccc1cccnc12 | 10.1021/jm301121j | |||
3258407 | 84938 | None | 14 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 389 | 9 | 1 | 5 | 4.9 | C=C(C)Cc1c(C)c(C#N)c2nc3ccccc3n2c1NCCCN(CC)CC | 10.1021/jm061389p | |||
CHEMBL223686 | 84938 | None | 14 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 389 | 9 | 1 | 5 | 4.9 | C=C(C)Cc1c(C)c(C#N)c2nc3ccccc3n2c1NCCCN(CC)CC | 10.1021/jm061389p | |||
12987698 | 83823 | None | 3 | Human | Functional | pEC50 | = | 5.7 | 5.7 | 2 | 3 | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1cnc2c(ccc3cc(C)cnc32)c1 | 10.1021/jm301121j | |||
CHEMBL2205809 | 83823 | None | 3 | Human | Functional | pEC50 | = | 5.7 | 5.7 | 2 | 3 | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1cnc2c(ccc3cc(C)cnc32)c1 | 10.1021/jm301121j | |||
1474 | 154488 | None | 79 | Human | Functional | pEC50 | = | 4.7 | 4.7 | -1 | 3 | ChEMBL | 156 | 1 | 0 | 2 | 2.1 | c1ccc(-c2ccccn2)nc1 | 10.1021/jm301121j | |||
CHEMBL39879 | 154488 | None | 79 | Human | Functional | pEC50 | = | 4.7 | 4.7 | -1 | 3 | ChEMBL | 156 | 1 | 0 | 2 | 2.1 | c1ccc(-c2ccccn2)nc1 | 10.1021/jm301121j | |||
12987698 | 83823 | None | 3 | Human | Functional | pEC50 | = | 5.7 | 5.7 | 2 | 3 | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1cnc2c(ccc3cc(C)cnc32)c1 | 10.1021/jm301121j | |||
CHEMBL2205809 | 83823 | None | 3 | Human | Functional | pEC50 | = | 5.7 | 5.7 | 2 | 3 | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1cnc2c(ccc3cc(C)cnc32)c1 | 10.1021/jm301121j | |||
15783796 | 83825 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -3 | 3 | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1cnc2c(ccc3cccnc32)c1 | 10.1021/jm301121j | |||
CHEMBL2205810 | 83825 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -3 | 3 | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1cnc2c(ccc3cccnc32)c1 | 10.1021/jm301121j | |||
93149 | 107257 | None | 55 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -16 | 3 | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1ccnc2c1ccc1cccnc12 | 10.1021/jm301121j | |||
CHEMBL316589 | 107257 | None | 55 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -16 | 3 | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1ccnc2c1ccc1cccnc12 | 10.1021/jm301121j | |||
2733927 | 83822 | None | 59 | Human | Functional | pEC50 | = | 4.7 | 4.7 | -4 | 3 | ChEMBL | 216 | 3 | 0 | 4 | 2.2 | COc1ccnc(-c2cc(OC)ccn2)c1 | 10.1021/jm301121j | |||
CHEMBL2205808 | 83822 | None | 59 | Human | Functional | pEC50 | = | 4.7 | 4.7 | -4 | 3 | ChEMBL | 216 | 3 | 0 | 4 | 2.2 | COc1ccnc(-c2cc(OC)ccn2)c1 | 10.1021/jm301121j | |||
1474 | 154488 | None | 79 | Human | Functional | pEC50 | = | 4.7 | 4.7 | -1 | 3 | ChEMBL | 156 | 1 | 0 | 2 | 2.1 | c1ccc(-c2ccccn2)nc1 | 10.1021/jm301121j | |||
CHEMBL39879 | 154488 | None | 79 | Human | Functional | pEC50 | = | 4.7 | 4.7 | -1 | 3 | ChEMBL | 156 | 1 | 0 | 2 | 2.1 | c1ccc(-c2ccccn2)nc1 | 10.1021/jm301121j | |||
16728788 | 83468 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 450 | 7 | 1 | 7 | 3.4 | Cc1cc(CN2CCN(C)CC2)ccc1NC(=O)CSc1nnc(C)n1-c1ccccc1 | 10.1021/jm061389p | |||
CHEMBL219770 | 83468 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 450 | 7 | 1 | 7 | 3.4 | Cc1cc(CN2CCN(C)CC2)ccc1NC(=O)CSc1nnc(C)n1-c1ccccc1 | 10.1021/jm061389p | |||
15783796 | 83825 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -3 | 3 | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1cnc2c(ccc3cccnc32)c1 | 10.1021/jm301121j | |||
CHEMBL2205810 | 83825 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -3 | 3 | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1cnc2c(ccc3cccnc32)c1 | 10.1021/jm301121j | |||
2733927 | 83822 | None | 59 | Human | Functional | pEC50 | = | 4.7 | 4.7 | -4 | 3 | ChEMBL | 216 | 3 | 0 | 4 | 2.2 | COc1ccnc(-c2cc(OC)ccn2)c1 | 10.1021/jm301121j | |||
CHEMBL2205808 | 83822 | None | 59 | Human | Functional | pEC50 | = | 4.7 | 4.7 | -4 | 3 | ChEMBL | 216 | 3 | 0 | 4 | 2.2 | COc1ccnc(-c2cc(OC)ccn2)c1 | 10.1021/jm301121j | |||
15664 | 83821 | None | 63 | Human | Functional | pEC50 | = | 5.6 | 5.6 | 2 | 3 | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccc(-c2ccc(C)cn2)nc1 | 10.1021/jm301121j | |||
CHEMBL2205807 | 83821 | None | 63 | Human | Functional | pEC50 | = | 5.6 | 5.6 | 2 | 3 | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccc(-c2ccc(C)cn2)nc1 | 10.1021/jm301121j | |||
137660245 | 159379 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 461 | 7 | 1 | 4 | 4.4 | CC(C)CN1CC(C(=O)Nc2ccc(CN(C)C3CCOCC3)cc2)=Cc2ccccc2C1=O | 10.1016/j.ejmech.2017.04.046 | |||
CHEMBL4099473 | 159379 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 461 | 7 | 1 | 4 | 4.4 | CC(C)CN1CC(C(=O)Nc2ccc(CN(C)C3CCOCC3)cc2)=Cc2ccccc2C1=O | 10.1016/j.ejmech.2017.04.046 | |||
15664 | 83821 | None | 63 | Human | Functional | pEC50 | = | 5.6 | 5.6 | 2 | 3 | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccc(-c2ccc(C)cn2)nc1 | 10.1021/jm301121j | |||
CHEMBL2205807 | 83821 | None | 63 | Human | Functional | pEC50 | = | 5.6 | 5.6 | 2 | 3 | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccc(-c2ccc(C)cn2)nc1 | 10.1021/jm301121j | |||
72792 | 202179 | None | 52 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -5 | 3 | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1ccnc2c1ccc1c(C)ccnc12 | 10.1021/jm301121j | |||
CHEMBL593442 | 202179 | None | 52 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -5 | 3 | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1ccnc2c1ccc1c(C)ccnc12 | 10.1021/jm301121j | |||
72792 | 202179 | None | 52 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -5 | 3 | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1ccnc2c1ccc1c(C)ccnc12 | 10.1021/jm301121j | |||
CHEMBL593442 | 202179 | None | 52 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -5 | 3 | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1ccnc2c1ccc1c(C)ccnc12 | 10.1021/jm301121j | |||
70848 | 209130 | None | 67 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -5 | 3 | ChEMBL | 233 | 2 | 0 | 3 | 3.2 | c1ccc(-c2cccc(-c3ccccn3)n2)nc1 | 10.1021/jm301121j | |||
CHEMBL89445 | 209130 | None | 67 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -5 | 3 | ChEMBL | 233 | 2 | 0 | 3 | 3.2 | c1ccc(-c2cccc(-c3ccccn3)n2)nc1 | 10.1021/jm301121j | |||
1167892 | 83470 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 463 | 9 | 1 | 6 | 4.7 | Cc1ccc(NC(=O)CSc2nnc(CCN3CCCCC3)n2Cc2ccccc2)c(C)c1 | 10.1021/jm061389p | |||
CHEMBL219781 | 83470 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 463 | 9 | 1 | 6 | 4.7 | Cc1ccc(NC(=O)CSc2nnc(CCN3CCCCC3)n2Cc2ccccc2)c(C)c1 | 10.1021/jm061389p | |||
70848 | 209130 | None | 67 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -5 | 3 | ChEMBL | 233 | 2 | 0 | 3 | 3.2 | c1ccc(-c2cccc(-c3ccccn3)n2)nc1 | 10.1021/jm301121j | |||
CHEMBL89445 | 209130 | None | 67 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -5 | 3 | ChEMBL | 233 | 2 | 0 | 3 | 3.2 | c1ccc(-c2cccc(-c3ccccn3)n2)nc1 | 10.1021/jm301121j | |||
10585 | 1079 | None | 1 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
145996522 | 1079 | None | 1 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4531005 | 1079 | None | 1 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
12425 | 6 | None | 76 | Human | Functional | pEC50 | = | 5.3 | 5.3 | -4 | 4 | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | |||
1318 | 6 | None | 76 | Human | Functional | pEC50 | = | 5.3 | 5.3 | -4 | 4 | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | |||
CHEMBL415879 | 6 | None | 76 | Human | Functional | pEC50 | = | 5.3 | 5.3 | -4 | 4 | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | |||
DB02365 | 6 | None | 76 | Human | Functional | pEC50 | = | 5.3 | 5.3 | -4 | 4 | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | |||
10585 | 1079 | None | 1 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
145996522 | 1079 | None | 1 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4531005 | 1079 | None | 1 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
155491018 | 174187 | None | 1 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 2 | 2 | ChEMBL | 395 | 3 | 2 | 5 | 3.1 | CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4544504 | 174187 | None | 1 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 2 | 2 | ChEMBL | 395 | 3 | 2 | 5 | 3.1 | CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 | 10.1021/acs.jmedchem.9b00742 | |||
155491018 | 174187 | None | 1 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 2 | 2 | ChEMBL | 395 | 3 | 2 | 5 | 3.1 | CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4544504 | 174187 | None | 1 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 2 | 2 | ChEMBL | 395 | 3 | 2 | 5 | 3.1 | CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 | 10.1021/acs.jmedchem.9b00742 | |||
12425 | 6 | None | 76 | Human | Functional | pEC50 | = | 5.3 | 5.3 | -4 | 4 | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | |||
1318 | 6 | None | 76 | Human | Functional | pEC50 | = | 5.3 | 5.3 | -4 | 4 | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | |||
CHEMBL415879 | 6 | None | 76 | Human | Functional | pEC50 | = | 5.3 | 5.3 | -4 | 4 | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | |||
DB02365 | 6 | None | 76 | Human | Functional | pEC50 | = | 5.3 | 5.3 | -4 | 4 | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | |||
155491018 | 174187 | None | 1 | Human | Functional | pEC50 | = | 8.2 | 8.2 | 2 | 2 | ChEMBL | 395 | 3 | 2 | 5 | 3.1 | CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4544504 | 174187 | None | 1 | Human | Functional | pEC50 | = | 8.2 | 8.2 | 2 | 2 | ChEMBL | 395 | 3 | 2 | 5 | 3.1 | CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 | 10.1021/acs.jmedchem.9b00742 | |||
155491018 | 174187 | None | 1 | Human | Functional | pEC50 | = | 8.2 | 8.2 | 2 | 2 | ChEMBL | 395 | 3 | 2 | 5 | 3.1 | CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4544504 | 174187 | None | 1 | Human | Functional | pEC50 | = | 8.2 | 8.2 | 2 | 2 | ChEMBL | 395 | 3 | 2 | 5 | 3.1 | CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 | 10.1021/acs.jmedchem.9b00742 | |||
65237 | 137711 | None | 68 | Human | Functional | pEC50 | = | 4.2 | 4.2 | -28 | 2 | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1ccc2ccc3ccc(C)nc3c2n1 | 10.1021/jm301121j | |||
CHEMBL375781 | 137711 | None | 68 | Human | Functional | pEC50 | = | 4.2 | 4.2 | -28 | 2 | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1ccc2ccc3ccc(C)nc3c2n1 | 10.1021/jm301121j | |||
65237 | 137711 | None | 68 | Human | Functional | pEC50 | = | 4.2 | 4.2 | -28 | 2 | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1ccc2ccc3ccc(C)nc3c2n1 | 10.1021/jm301121j | |||
CHEMBL375781 | 137711 | None | 68 | Human | Functional | pEC50 | = | 4.2 | 4.2 | -28 | 2 | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1ccc2ccc3ccc(C)nc3c2n1 | 10.1021/jm301121j | |||
183790 | 3742 | None | 8 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -2 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1016/j.ejmech.2017.04.046 | |||
783 | 3742 | None | 8 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -2 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1016/j.ejmech.2017.04.046 | |||
CHEMBL1178786 | 3742 | None | 8 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -2 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1016/j.ejmech.2017.04.046 | |||
10585 | 1079 | None | 1 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
145996522 | 1079 | None | 1 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4531005 | 1079 | None | 1 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
10585 | 1079 | None | 1 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
145996522 | 1079 | None | 1 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4531005 | 1079 | None | 1 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
10585 | 1079 | None | 1 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
145996522 | 1079 | None | 1 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4531005 | 1079 | None | 1 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
155491018 | 174187 | None | 1 | Human | Functional | pEC50 | = | 8.1 | 8.1 | 2 | 2 | ChEMBL | 395 | 3 | 2 | 5 | 3.1 | CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4544504 | 174187 | None | 1 | Human | Functional | pEC50 | = | 8.1 | 8.1 | 2 | 2 | ChEMBL | 395 | 3 | 2 | 5 | 3.1 | CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 | 10.1021/acs.jmedchem.9b00742 | |||
10585 | 1079 | None | 1 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
145996522 | 1079 | None | 1 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4531005 | 1079 | None | 1 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -1 | 2 | ChEMBL | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 10.1021/acs.jmedchem.9b00742 | |||
155491018 | 174187 | None | 1 | Human | Functional | pEC50 | = | 8.1 | 8.1 | 2 | 2 | ChEMBL | 395 | 3 | 2 | 5 | 3.1 | CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 | 10.1021/acs.jmedchem.9b00742 | |||
CHEMBL4544504 | 174187 | None | 1 | Human | Functional | pEC50 | = | 8.1 | 8.1 | 2 | 2 | ChEMBL | 395 | 3 | 2 | 5 | 3.1 | CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 | 10.1021/acs.jmedchem.9b00742 | |||
11151928 | 189596 | None | 0 | Human | Functional | pED50 | = | 9.1 | 9.1 | -10 | 4 | ChEMBL | 338 | 11 | 2 | 2 | 4.3 | CCCCCCCCCCC(C)(C)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
CHEMBL513863 | 189596 | None | 0 | Human | Functional | pED50 | = | 9.1 | 9.1 | -10 | 4 | ChEMBL | 338 | 11 | 2 | 2 | 4.3 | CCCCCCCCCCC(C)(C)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | |||
15941255 | 81804 | None | 0 | Human | Functional | pIC50 | = | 10.1 | 10.1 | - | 1 | ChEMBL | 527 | 9 | 2 | 6 | 4.5 | CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2Cl)CC1 | 10.1021/ml2002604 | |||
CHEMBL2164207 | 81804 | None | 0 | Human | Functional | pIC50 | = | 10.1 | 10.1 | - | 1 | ChEMBL | 527 | 9 | 2 | 6 | 4.5 | CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2Cl)CC1 | 10.1021/ml2002604 | |||
57402801 | 69245 | None | 0 | Human | Functional | pIC50 | = | 10.1 | 10.1 | - | 1 | ChEMBL | 600 | 12 | 2 | 7 | 5.2 | COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(C(=O)NC(C)C)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926899 | 69245 | None | 0 | Human | Functional | pIC50 | = | 10.1 | 10.1 | - | 1 | ChEMBL | 600 | 12 | 2 | 7 | 5.2 | COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(C(=O)NC(C)C)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
50993591 | 57225 | None | 0 | Human | Functional | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 497 | 6 | 1 | 6 | 3.9 | COC(=O)N1CCc2nc(C)n([C@@H]3C[C@@H]4CC[C@H](C3)N4CC[C@H](NC(C)=O)c3cccc(F)c3)c2C1 | 10.1021/jm100978n | |||
CHEMBL1649924 | 57225 | None | 0 | Human | Functional | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 497 | 6 | 1 | 6 | 3.9 | COC(=O)N1CCc2nc(C)n([C@@H]3C[C@@H]4CC[C@H](C3)N4CC[C@H](NC(C)=O)c3cccc(F)c3)c2C1 | 10.1021/jm100978n | |||
15940800 | 81799 | None | 0 | Human | Functional | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 561 | 10 | 1 | 7 | 3.9 | Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)CN2CCOC2=O)CC1 | 10.1021/ml2002604 | |||
CHEMBL2164202 | 81799 | None | 0 | Human | Functional | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 561 | 10 | 1 | 7 | 3.9 | Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)CN2CCOC2=O)CC1 | 10.1021/ml2002604 | |||
15941086 | 81807 | None | 0 | Human | Functional | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 518 | 9 | 2 | 7 | 3.7 | CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(C#N)nc2Cl)CC1 | 10.1021/ml2002604 | |||
CHEMBL2164210 | 81807 | None | 0 | Human | Functional | pIC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 518 | 9 | 2 | 7 | 3.7 | CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(C#N)nc2Cl)CC1 | 10.1021/ml2002604 | |||
11285792 | 879 | None | 32 | Human | Functional | pIC50 | = | 10 | 10.0 | -3 | 6 | ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1021/jm0509703 | |||
801 | 879 | None | 32 | Human | Functional | pIC50 | = | 10 | 10.0 | -3 | 6 | ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1021/jm0509703 | |||
CHEMBL2110727 | 879 | None | 32 | Human | Functional | pIC50 | = | 10 | 10.0 | -3 | 6 | ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1021/jm0509703 | |||
DB11758 | 879 | None | 32 | Human | Functional | pIC50 | = | 10 | 10.0 | -3 | 6 | ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1021/jm0509703 | |||
62706107 | 81814 | None | 0 | Human | Functional | pIC50 | = | 10.0 | 10.0 | - | 1 | ChEMBL | 554 | 9 | 2 | 6 | 5.5 | Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)Nc2cccnc2)CC1 | 10.1021/ml2002604 | |||
CHEMBL2164217 | 81814 | None | 0 | Human | Functional | pIC50 | = | 10.0 | 10.0 | - | 1 | ChEMBL | 554 | 9 | 2 | 6 | 5.5 | Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)Nc2cccnc2)CC1 | 10.1021/ml2002604 | |||
11650548 | 103597 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 697 | 17 | 1 | 8 | 8.1 | CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4nncn4CCC)cc2)CCCN3CC(C)C)cc1 | 10.1021/jm0509703 | |||
CHEMBL3085308 | 103597 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 697 | 17 | 1 | 8 | 8.1 | CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4nncn4CCC)cc2)CCCN3CC(C)C)cc1 | 10.1021/jm0509703 | |||
15947119 | 69239 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 549 | 10 | 1 | 6 | 5.7 | COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926893 | 69239 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 549 | 10 | 1 | 6 | 5.7 | COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
3002977 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.7 | 9.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/jm100978n | |||
3002977.0 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.7 | 9.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/jm100978n | |||
803 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.7 | 9.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/jm100978n | |||
806 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.7 | 9.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/jm100978n | |||
CHEMBL1201187 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.7 | 9.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/jm100978n | |||
CHEMBL256907 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.7 | 9.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/jm100978n | |||
CHEMBL584744 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.7 | 9.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/jm100978n | |||
DB04835 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.7 | 9.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/jm100978n | |||
50993593 | 57227 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 497 | 6 | 1 | 6 | 3.9 | COC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(C)=O)CC3)C2)c1cccc(F)c1 | 10.1021/jm100978n | |||
CHEMBL1649926 | 57227 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 497 | 6 | 1 | 6 | 3.9 | COC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(C)=O)CC3)C2)c1cccc(F)c1 | 10.1021/jm100978n | |||
50992494 | 57228 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 513 | 6 | 1 | 7 | 4.1 | COC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(=O)OC)CC3)C2)c1cccc(F)c1 | 10.1021/jm100978n | |||
CHEMBL1649927 | 57228 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 513 | 6 | 1 | 7 | 4.1 | COC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(=O)OC)CC3)C2)c1cccc(F)c1 | 10.1021/jm100978n | |||
3002977 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.7 | 9.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmc.2016.12.035 | |||
3002977.0 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.7 | 9.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmc.2016.12.035 | |||
803 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.7 | 9.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmc.2016.12.035 | |||
806 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.7 | 9.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmc.2016.12.035 | |||
CHEMBL1201187 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.7 | 9.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmc.2016.12.035 | |||
CHEMBL256907 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.7 | 9.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmc.2016.12.035 | |||
CHEMBL584744 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.7 | 9.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmc.2016.12.035 | |||
DB04835 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.7 | 9.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmc.2016.12.035 | |||
11285792 | 879 | None | 32 | Human | Functional | pIC50 | = | 9.7 | 9.7 | -3 | 6 | ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1021/jm0509703 | |||
801 | 879 | None | 32 | Human | Functional | pIC50 | = | 9.7 | 9.7 | -3 | 6 | ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1021/jm0509703 | |||
CHEMBL2110727 | 879 | None | 32 | Human | Functional | pIC50 | = | 9.7 | 9.7 | -3 | 6 | ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1021/jm0509703 | |||
DB11758 | 879 | None | 32 | Human | Functional | pIC50 | = | 9.7 | 9.7 | -3 | 6 | ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1021/jm0509703 | |||
11513274 | 103598 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 734 | 17 | 1 | 9 | 8.0 | CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCN3Cc2cnn(C)c2)cc1 | 10.1021/jm0509703 | |||
CHEMBL3085309 | 103598 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 734 | 17 | 1 | 9 | 8.0 | CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCN3Cc2cnn(C)c2)cc1 | 10.1021/jm0509703 | |||
9810893 | 103596 | None | 0 | Human | Functional | pIC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 682 | 17 | 1 | 7 | 8.5 | CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCN3CCC)cc1 | 10.1021/jm0509703 | |||
CHEMBL3085307 | 103596 | None | 0 | Human | Functional | pIC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 682 | 17 | 1 | 7 | 8.5 | CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCN3CCC)cc1 | 10.1021/jm0509703 | |||
44511934 | 69242 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 533 | 10 | 1 | 6 | 5.2 | COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(F)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926896 | 69242 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 533 | 10 | 1 | 6 | 5.2 | COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(F)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
44512090 | 69244 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 540 | 10 | 1 | 7 | 5.0 | COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(C#N)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926898 | 69244 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 540 | 10 | 1 | 7 | 5.0 | COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(C#N)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
44512058 | 69253 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 551 | 10 | 1 | 8 | 4.5 | COc1ccc(N(Cc2cccc(C#N)n2)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(C#N)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1927008 | 69253 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 551 | 10 | 1 | 8 | 4.5 | COc1ccc(N(Cc2cccc(C#N)n2)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(C#N)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
44511938 | 69254 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 560 | 10 | 1 | 7 | 5.3 | COc1ccc(N(Cc2cccc(C#N)n2)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1927009 | 69254 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 560 | 10 | 1 | 7 | 5.3 | COc1ccc(N(Cc2cccc(C#N)n2)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
50992641 | 57224 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 479 | 6 | 1 | 6 | 3.8 | COC(=O)N1CCc2nc(C)n([C@@H]3C[C@@H]4CC[C@H](C3)N4CC[C@H](NC(C)=O)c3ccccc3)c2C1 | 10.1021/jm100978n | |||
CHEMBL1649922 | 57224 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 479 | 6 | 1 | 6 | 3.8 | COC(=O)N1CCc2nc(C)n([C@@H]3C[C@@H]4CC[C@H](C3)N4CC[C@H](NC(C)=O)c3ccccc3)c2C1 | 10.1021/jm100978n | |||
62706110 | 81800 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 491 | 8 | 2 | 5 | 4.2 | CNC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 | 10.1021/ml2002604 | |||
CHEMBL2164203 | 81800 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 491 | 8 | 2 | 5 | 4.2 | CNC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 | 10.1021/ml2002604 | |||
15940799 | 81802 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 493 | 8 | 3 | 6 | 4.0 | Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)NO)CC1 | 10.1021/ml2002604 | |||
CHEMBL2164205 | 81802 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 493 | 8 | 3 | 6 | 4.0 | Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)NO)CC1 | 10.1021/ml2002604 | |||
57384005 | 81803 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 507 | 9 | 2 | 6 | 4.2 | CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 | 10.1021/ml2002604 | |||
CHEMBL2164206 | 81803 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 507 | 9 | 2 | 6 | 4.2 | CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 | 10.1021/ml2002604 | |||
57384006 | 81808 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 551 | 12 | 2 | 7 | 4.2 | COCCONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 | 10.1021/ml2002604 | |||
CHEMBL2164211 | 81808 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 551 | 12 | 2 | 7 | 4.2 | COCCONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 | 10.1021/ml2002604 | |||
50915506 | 19052 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 848 | 11 | 2 | 6 | 8.2 | CC(C)(C)NS(=O)(=O)c1cc(C(=O)N2CCC(CCN3CCC(N(C(=O)NCc4ccc(C#N)cc4)c4cccc(F)c4)CC3)(c3cccc(F)c3)CC2)c(Cl)cc1F | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288663 | 19052 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 848 | 11 | 2 | 6 | 8.2 | CC(C)(C)NS(=O)(=O)c1cc(C(=O)N2CCC(CCN3CCC(N(C(=O)NCc4ccc(C#N)cc4)c4cccc(F)c4)CC3)(c3cccc(F)c3)CC2)c(Cl)cc1F | 10.1016/j.bmcl.2010.10.033 | |||
44455217 | 95472 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 608 | 7 | 1 | 5 | 6.4 | CC(=O)N1CCc2c(nc(C)n2[C@H]2C[C@@H]3CC[C@H](C2)N3CCCN(C(=O)Nc2ccc(C(F)(F)F)cc2)c2ccccc2)C1 | 10.1016/j.bmcl.2007.12.058 | |||
CHEMBL257000 | 95472 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 608 | 7 | 1 | 5 | 6.4 | CC(=O)N1CCc2c(nc(C)n2[C@H]2C[C@@H]3CC[C@H](C2)N3CCCN(C(=O)Nc2ccc(C(F)(F)F)cc2)c2ccccc2)C1 | 10.1016/j.bmcl.2007.12.058 | |||
50992577 | 57220 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 463 | 6 | 1 | 5 | 3.5 | CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(C)=O)CC3)C2)c1ccccc1 | 10.1021/jm100978n | |||
CHEMBL1649919 | 57220 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 463 | 6 | 1 | 5 | 3.5 | CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(C)=O)CC3)C2)c1ccccc1 | 10.1021/jm100978n | |||
50992639 | 57222 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 477 | 7 | 1 | 5 | 3.9 | CCC(=O)N1CCc2nc(C)n([C@@H]3C[C@@H]4CC[C@H](C3)N4CC[C@H](NC(C)=O)c3ccccc3)c2C1 | 10.1021/jm100978n | |||
CHEMBL1649920 | 57222 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 477 | 7 | 1 | 5 | 3.9 | CCC(=O)N1CCc2nc(C)n([C@@H]3C[C@@H]4CC[C@H](C3)N4CC[C@H](NC(C)=O)c3ccccc3)c2C1 | 10.1021/jm100978n | |||
50992640 | 57223 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 491 | 7 | 1 | 5 | 4.2 | CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(=O)C(C)C)CC3)C2)c1ccccc1 | 10.1021/jm100978n | |||
CHEMBL1649921 | 57223 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 491 | 7 | 1 | 5 | 4.2 | CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(=O)C(C)C)CC3)C2)c1ccccc1 | 10.1021/jm100978n | |||
59458228 | 81805 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 558 | 11 | 3 | 7 | 3.6 | CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(C(=O)NC(C)C)nc2C)CC1 | 10.1021/ml2002604 | |||
CHEMBL2164208 | 81805 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 558 | 11 | 3 | 7 | 3.6 | CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(C(=O)NC(C)C)nc2C)CC1 | 10.1021/ml2002604 | |||
59458061 | 81806 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 543 | 9 | 2 | 6 | 3.7 | CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)[n+]([O-])c2Cl)CC1 | 10.1021/ml2002604 | |||
CHEMBL2164209 | 81806 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 543 | 9 | 2 | 6 | 3.7 | CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)[n+]([O-])c2Cl)CC1 | 10.1021/ml2002604 | |||
15941083 | 81816 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 506 | 10 | 1 | 6 | 4.1 | COCC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 | 10.1021/ml2002604 | |||
CHEMBL2164219 | 81816 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 506 | 10 | 1 | 6 | 4.1 | COCC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 | 10.1021/ml2002604 | |||
15940801 | 81817 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 501 | 9 | 1 | 6 | 4.3 | Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)CC#N)CC1 | 10.1021/ml2002604 | |||
CHEMBL2164220 | 81817 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 501 | 9 | 1 | 6 | 4.3 | Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)CC#N)CC1 | 10.1021/ml2002604 | |||
5275766 | 3738 | None | 34 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 552 | 9 | 1 | 4 | 4.7 | CC(=O)N1CCC(CC1)C(=O)N(c1ccc(c(c1)Cl)C)CCCN1CCC(CC1)Cc1ccc(cc1)C(=O)N | 10.1021/jm051034q | |||
800 | 3738 | None | 34 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 552 | 9 | 1 | 4 | 4.7 | CC(=O)N1CCC(CC1)C(=O)N(c1ccc(c(c1)Cl)C)CCCN1CCC(CC1)Cc1ccc(cc1)C(=O)N | 10.1021/jm051034q | |||
CHEMBL207004 | 3738 | None | 34 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 552 | 9 | 1 | 4 | 4.7 | CC(=O)N1CCC(CC1)C(=O)N(c1ccc(c(c1)Cl)C)CCCN1CCC(CC1)Cc1ccc(cc1)C(=O)N | 10.1021/jm051034q | |||
11700429 | 103600 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 710 | 17 | 1 | 7 | 9.1 | CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCCN3CC(C)C)cc1 | 10.1021/jm0509703 | |||
CHEMBL3085311 | 103600 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 710 | 17 | 1 | 7 | 9.1 | CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCCN3CC(C)C)cc1 | 10.1021/jm0509703 | |||
53325983 | 57214 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 416 | 6 | 1 | 4 | 4.8 | CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3ccccc31)C2)c1ccccc1 | 10.1021/jm100978n | |||
CHEMBL1649913 | 57214 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 416 | 6 | 1 | 4 | 4.8 | CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3ccccc31)C2)c1ccccc1 | 10.1021/jm100978n | |||
15940498 | 81809 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 611 | 11 | 3 | 6 | 5.5 | Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)NCc2ccc(C(=O)O)cc2)CC1 | 10.1021/ml2002604 | |||
CHEMBL2164212 | 81809 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 611 | 11 | 3 | 6 | 5.5 | Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)NCc2ccc(C(=O)O)cc2)CC1 | 10.1021/ml2002604 | |||
457871 | 100777 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 483 | 4 | 1 | 3 | 5.6 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(Br)cc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL292625 | 100777 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 483 | 4 | 1 | 3 | 5.6 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(Br)cc3)CC2)CC1 | 10.1021/jm031046g | |||
44511935 | 69246 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 593 | 13 | 1 | 7 | 5.8 | COCCOc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926900 | 69246 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 593 | 13 | 1 | 7 | 5.8 | COCCOc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
50993592 | 57226 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 479 | 6 | 1 | 6 | 3.8 | COC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(C)=O)CC3)C2)c1ccccc1 | 10.1021/jm100978n | |||
CHEMBL1649925 | 57226 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 479 | 6 | 1 | 6 | 3.8 | COC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(C)=O)CC3)C2)c1ccccc1 | 10.1021/jm100978n | |||
3008904 | 202422 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 1 | 2 | ChEMBL | 537 | 6 | 0 | 5 | 5.0 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3cccc(C#N)c3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL59511 | 202422 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 1 | 2 | ChEMBL | 537 | 6 | 0 | 5 | 5.0 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3cccc(C#N)c3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
11614352 | 550 | None | 1 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 639 | 11 | 0 | 6 | 4.1 | CCN(C(=O)Cc1ccc(cc1)S(=O)(=O)C)C1CCN(CC1)CC[C@@H](c1cc(F)cc(c1)F)C1CCN(CC1)S(=O)(=O)C | 10.1016/j.bmcl.2011.12.117 | |||
7686 | 550 | None | 1 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 639 | 11 | 0 | 6 | 4.1 | CCN(C(=O)Cc1ccc(cc1)S(=O)(=O)C)C1CCN(CC1)CC[C@@H](c1cc(F)cc(c1)F)C1CCN(CC1)S(=O)(=O)C | 10.1016/j.bmcl.2011.12.117 | |||
CHEMBL1951914 | 550 | None | 1 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 639 | 11 | 0 | 6 | 4.1 | CCN(C(=O)Cc1ccc(cc1)S(=O)(=O)C)C1CCN(CC1)CC[C@@H](c1cc(F)cc(c1)F)C1CCN(CC1)S(=O)(=O)C | 10.1016/j.bmcl.2011.12.117 | |||
57392303 | 69237 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 535 | 10 | 1 | 6 | 5.4 | COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)ccnc3Cl)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926891 | 69237 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 535 | 10 | 1 | 6 | 5.4 | COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)ccnc3Cl)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
44512001 | 69255 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 544 | 10 | 1 | 7 | 4.8 | COc1ccc(N(Cc2cccc(C#N)n2)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(F)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1927010 | 69255 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 544 | 10 | 1 | 7 | 4.8 | COc1ccc(N(Cc2cccc(C#N)n2)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(F)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
62706106 | 81812 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 560 | 10 | 1 | 6 | 5.2 | Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)CC2CCOCC2)CC1 | 10.1021/ml2002604 | |||
CHEMBL2164215 | 81812 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | ChEMBL | 560 | 10 | 1 | 6 | 5.2 | Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)CC2CCOCC2)CC1 | 10.1021/ml2002604 | |||
3008917 | 205241 | None | 3 | Human | Functional | pIC50 | = | 9.2 | 9.2 | -6 | 2 | ChEMBL | 481 | 5 | 0 | 3 | 6.6 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL62152 | 205241 | None | 3 | Human | Functional | pIC50 | = | 9.2 | 9.2 | -6 | 2 | ChEMBL | 481 | 5 | 0 | 3 | 6.6 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
23725098 | 195909 | None | 4 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | Cc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1 | 10.1016/j.ejmech.2023.115294 | |||
CHEMBL5413158 | 195909 | None | 4 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | Cc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1 | 10.1016/j.ejmech.2023.115294 | |||
3002977 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.1c00408 | |||
3002977.0 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.1c00408 | |||
803 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.1c00408 | |||
806 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.1c00408 | |||
CHEMBL1201187 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.1c00408 | |||
CHEMBL256907 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.1c00408 | |||
CHEMBL584744 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.1c00408 | |||
DB04835 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.1c00408 | |||
44511871 | 69247 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 584 | 13 | 1 | 8 | 5.0 | COCCOc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(C#N)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926901 | 69247 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 584 | 13 | 1 | 8 | 5.0 | COCCOc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(C#N)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
72711958 | 92708 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 574 | 9 | 1 | 5 | 5.4 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(Cc3ccncc3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435864 | 92708 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 574 | 9 | 1 | 5 | 5.4 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(Cc3ccncc3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
72711740 | 92753 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 581 | 9 | 1 | 5 | 5.2 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(CC3CCOCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435909 | 92753 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 581 | 9 | 1 | 5 | 5.2 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(CC3CCOCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
62706109 | 81798 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 551 | 10 | 1 | 7 | 4.5 | Cc1cc(C#N)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)CC2CCOCC2)CC1 | 10.1021/ml2002604 | |||
CHEMBL2164201 | 81798 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 551 | 10 | 1 | 7 | 4.5 | Cc1cc(C#N)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)CC2CCOCC2)CC1 | 10.1021/ml2002604 | |||
3008909 | 201556 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 473 | 4 | 1 | 3 | 5.9 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(C(F)(F)F)cc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL58897 | 201556 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 473 | 4 | 1 | 3 | 5.9 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(C(F)(F)F)cc3)CC2)CC1 | 10.1021/jm031046g | |||
3013701 | 77122 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 643 | 10 | 0 | 6 | 4.7 | CS(=O)(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(S(C)(=O)=O)CC3)c3ccc(Cl)c(Cl)c3)CC2)cc1 | 10.1021/jm051034q | |||
CHEMBL207487 | 77122 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 643 | 10 | 0 | 6 | 4.7 | CS(=O)(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(S(C)(=O)=O)CC3)c3ccc(Cl)c(Cl)c3)CC2)cc1 | 10.1021/jm051034q | |||
3002977 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.1c00781 | |||
3002977.0 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.1c00781 | |||
803 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.1c00781 | |||
806 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.1c00781 | |||
CHEMBL1201187 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.1c00781 | |||
CHEMBL256907 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.1c00781 | |||
CHEMBL584744 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.1c00781 | |||
DB04835 | 2460 | None | 43 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.1c00781 | |||
5275766 | 3738 | None | 34 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 552 | 9 | 1 | 4 | 4.7 | CC(=O)N1CCC(CC1)C(=O)N(c1ccc(c(c1)Cl)C)CCCN1CCC(CC1)Cc1ccc(cc1)C(=O)N | 10.1016/j.ejmech.2023.115294 | |||
800 | 3738 | None | 34 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 552 | 9 | 1 | 4 | 4.7 | CC(=O)N1CCC(CC1)C(=O)N(c1ccc(c(c1)Cl)C)CCCN1CCC(CC1)Cc1ccc(cc1)C(=O)N | 10.1016/j.ejmech.2023.115294 | |||
CHEMBL207004 | 3738 | None | 34 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 552 | 9 | 1 | 4 | 4.7 | CC(=O)N1CCC(CC1)C(=O)N(c1ccc(c(c1)Cl)C)CCCN1CCC(CC1)Cc1ccc(cc1)C(=O)N | 10.1016/j.ejmech.2023.115294 | |||
72711739 | 92751 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 551 | 8 | 1 | 4 | 5.7 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435907 | 92751 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 551 | 8 | 1 | 4 | 5.7 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
62706108 | 81815 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 476 | 8 | 1 | 5 | 4.4 | CC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 | 10.1021/ml2002604 | |||
CHEMBL2164218 | 81815 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 476 | 8 | 1 | 5 | 4.4 | CC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 | 10.1021/ml2002604 | |||
11636141 | 103599 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 683 | 17 | 1 | 8 | 7.9 | CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4nncn4CCC)cc2)CCCN3CCC)cc1 | 10.1021/jm0509703 | |||
CHEMBL3085310 | 103599 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 683 | 17 | 1 | 8 | 7.9 | CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4nncn4CCC)cc2)CCCN3CCC)cc1 | 10.1021/jm0509703 | |||
57402802 | 69250 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 583 | 12 | 2 | 8 | 3.8 | Cc1ccncc1CN(c1ccc(OCC(N)=O)cc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(C#N)nc2C)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926904 | 69250 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 583 | 12 | 2 | 8 | 3.8 | Cc1ccncc1CN(c1ccc(OCC(N)=O)cc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(C#N)nc2C)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
46225532 | 202129 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 547 | 6 | 0 | 5 | 3.8 | Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL593042 | 202129 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 547 | 6 | 0 | 5 | 3.8 | Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
3008928 | 205114 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | -1 | 2 | ChEMBL | 483 | 5 | 0 | 5 | 5.4 | Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL61424 | 205114 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | -1 | 2 | ChEMBL | 483 | 5 | 0 | 5 | 5.4 | Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
3013575 | 75797 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 682 | 17 | 1 | 7 | 8.4 | CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc([S+]([O-])Cc4cncn4CCC)cc2)CCN3CC(C)C)cc1 | 10.1021/jm0509703 | |||
CHEMBL204821 | 75797 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | - | 1 | ChEMBL | 682 | 17 | 1 | 7 | 8.4 | CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc([S+]([O-])Cc4cncn4CCC)cc2)CCN3CC(C)C)cc1 | 10.1021/jm0509703 | |||
73331746 | 197087 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 618 | 9 | 1 | 5 | 4.7 | CC(=O)N1CCC(C(=O)N(CCCN2C3CCC2CC(NS(=O)(=O)c2ccc(F)cc2)C3)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.ejmech.2023.115294 | |||
CHEMBL5438380 | 197087 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 618 | 9 | 1 | 5 | 4.7 | CC(=O)N1CCC(C(=O)N(CCCN2C3CCC2CC(NS(=O)(=O)c2ccc(F)cc2)C3)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.ejmech.2023.115294 | |||
49798082 | 10824 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 579 | 9 | 1 | 5 | 5.5 | C=CCN(C(=O)OCc1ccc(Cl)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172043 | 10824 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 579 | 9 | 1 | 5 | 5.5 | C=CCN(C(=O)OCc1ccc(Cl)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
44194590 | 10829 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 612 | 9 | 2 | 4 | 5.4 | C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172048 | 10829 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 612 | 9 | 2 | 4 | 5.4 | C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
11353001 | 58825 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 525 | 3 | 0 | 5 | 4.5 | Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN(C3CCc4cc(Br)ccc43)[C@@H](C)C2)CC1 | 10.1021/ml1001536 | |||
CHEMBL1688239 | 58825 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 525 | 3 | 0 | 5 | 4.5 | Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN(C3CCc4cc(Br)ccc43)[C@@H](C)C2)CC1 | 10.1021/ml1001536 | |||
11597 | 674 | None | 6 | Human | Functional | pIC50 | = | 9.0 | 9.0 | -11 | 2 | ChEMBL | 506 | 5 | 3 | 6 | 3.5 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C | 10.1021/acsmedchemlett.1c00373 | |||
23725180 | 674 | None | 6 | Human | Functional | pIC50 | = | 9.0 | 9.0 | -11 | 2 | ChEMBL | 506 | 5 | 3 | 6 | 3.5 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C | 10.1021/acsmedchemlett.1c00373 | |||
CHEMBL4781426 | 674 | None | 6 | Human | Functional | pIC50 | = | 9.0 | 9.0 | -11 | 2 | ChEMBL | 506 | 5 | 3 | 6 | 3.5 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C | 10.1021/acsmedchemlett.1c00373 | |||
51039119 | 176321 | None | 34 | Human | Functional | pIC50 | = | 9.0 | 9.0 | 1 | 3 | ChEMBL | 484 | 5 | 3 | 8 | 2.2 | CC(=O)N[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1N1CC[C@H](Nc2ncnc3cc(C(C)(C)C)nn23)C1=O | 10.1021/acsmedchemlett.1c00373 | |||
CHEMBL4594419 | 176321 | None | 34 | Human | Functional | pIC50 | = | 9.0 | 9.0 | 1 | 3 | ChEMBL | 484 | 5 | 3 | 8 | 2.2 | CC(=O)N[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1N1CC[C@H](Nc2ncnc3cc(C(C)(C)C)nn23)C1=O | 10.1021/acsmedchemlett.1c00373 | |||
3008927 | 201314 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | -2 | 2 | ChEMBL | 482 | 5 | 0 | 4 | 6.0 | Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL58387 | 201314 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | -2 | 2 | ChEMBL | 482 | 5 | 0 | 4 | 6.0 | Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
3008909 | 201556 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 473 | 4 | 1 | 3 | 5.9 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(C(F)(F)F)cc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL58897 | 201556 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 473 | 4 | 1 | 3 | 5.9 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(C(F)(F)F)cc3)CC2)CC1 | 10.1021/jm031046g | |||
72711956 | 92706 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 588 | 9 | 1 | 5 | 5.7 | Cc1ccncc1CN1C[C@@H](c2ccccc2)N(C2CCN(C(C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)C1=O | 10.1021/jm401101p | |||
CHEMBL2435862 | 92706 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 588 | 9 | 1 | 5 | 5.7 | Cc1ccncc1CN1C[C@@H](c2ccccc2)N(C2CCN(C(C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)C1=O | 10.1021/jm401101p | |||
3009355 | 3989 | None | 18 | Human | Functional | pIC50 | = | 8.9 | 8.9 | -1 | 2 | ChEMBL | 533 | 6 | 0 | 6 | 4.5 | COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F | 10.1021/ml1001536 | |||
807 | 3989 | None | 18 | Human | Functional | pIC50 | = | 8.9 | 8.9 | -1 | 2 | ChEMBL | 533 | 6 | 0 | 6 | 4.5 | COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F | 10.1021/ml1001536 | |||
CHEMBL82301 | 3989 | None | 18 | Human | Functional | pIC50 | = | 8.9 | 8.9 | -1 | 2 | ChEMBL | 533 | 6 | 0 | 6 | 4.5 | COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F | 10.1021/ml1001536 | |||
DB06652 | 3989 | None | 18 | Human | Functional | pIC50 | = | 8.9 | 8.9 | -1 | 2 | ChEMBL | 533 | 6 | 0 | 6 | 4.5 | COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F | 10.1021/ml1001536 | |||
11605997 | 58827 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 515 | 3 | 0 | 5 | 4.8 | Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN(C3CCc4cc(C(F)(F)F)ccc43)[C@@H](C)C2)CC1 | 10.1021/ml1001536 | |||
CHEMBL1688240 | 58827 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 515 | 3 | 0 | 5 | 4.8 | Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN(C3CCc4cc(C(F)(F)F)ccc43)[C@@H](C)C2)CC1 | 10.1021/ml1001536 | |||
71458736 | 81810 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 507 | 10 | 1 | 7 | 4.8 | COc1ccc(N(Cc2ccsc2)C2CCN([C@H](C)CCNC(=O)c3c(C)ncnc3C)CC2)cc1 | 10.1021/ml2002604 | |||
CHEMBL2164213 | 81810 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 507 | 10 | 1 | 7 | 4.8 | COc1ccc(N(Cc2ccsc2)C2CCN([C@H](C)CCNC(=O)c3c(C)ncnc3C)CC2)cc1 | 10.1021/ml2002604 | |||
183790 | 3742 | None | 8 | Human | Functional | pIC50 | = | 8.9 | 8.9 | -2 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1021/jm010468s | |||
783 | 3742 | None | 8 | Human | Functional | pIC50 | = | 8.9 | 8.9 | -2 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1021/jm010468s | |||
CHEMBL1178786 | 3742 | None | 8 | Human | Functional | pIC50 | = | 8.9 | 8.9 | -2 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1021/jm010468s | |||
44512349 | 69248 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 577 | 13 | 1 | 7 | 5.2 | COCCOc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(F)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926902 | 69248 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 577 | 13 | 1 | 7 | 5.2 | COCCOc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(F)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
72711742 | 92704 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 573 | 9 | 1 | 4 | 6.0 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(Cc3ccccc3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435860 | 92704 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 573 | 9 | 1 | 4 | 6.0 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(Cc3ccccc3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
49864971 | 15790 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 630 | 9 | 2 | 4 | 5.5 | C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2010.05.046 | |||
CHEMBL1222769 | 15790 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 630 | 9 | 2 | 4 | 5.5 | C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2010.05.046 | |||
49768863 | 57213 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | Cc1nc(C(C)C)n([C@@H]2C[C@@H]3CC[C@H](C2)N3CC[C@H](NC(=O)C2CCC(F)(F)CC2)c2ccccc2)n1 | 10.1021/jm100978n | |||
CHEMBL1649912 | 57213 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | Cc1nc(C(C)C)n([C@@H]2C[C@@H]3CC[C@H](C2)N3CC[C@H](NC(=O)C2CCC(F)(F)CC2)c2ccccc2)n1 | 10.1021/jm100978n | |||
3008913 | 102031 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | -1 | 2 | ChEMBL | 495 | 6 | 0 | 3 | 6.5 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL301454 | 102031 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | -1 | 2 | ChEMBL | 495 | 6 | 0 | 3 | 6.5 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
183790 | 3742 | None | 8 | Human | Functional | pIC50 | = | 8.9 | 8.9 | -2 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1016/s0960-894x(00)00347-4 | |||
783 | 3742 | None | 8 | Human | Functional | pIC50 | = | 8.9 | 8.9 | -2 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL1178786 | 3742 | None | 8 | Human | Functional | pIC50 | = | 8.9 | 8.9 | -2 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1016/s0960-894x(00)00347-4 | |||
183790 | 3742 | None | 8 | Human | Functional | pIC50 | = | 8.9 | 8.9 | -2 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1021/jm0509703 | |||
783 | 3742 | None | 8 | Human | Functional | pIC50 | = | 8.9 | 8.9 | -2 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1021/jm0509703 | |||
CHEMBL1178786 | 3742 | None | 8 | Human | Functional | pIC50 | = | 8.9 | 8.9 | -2 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1021/jm0509703 | |||
5275759 | 77145 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 590 | 9 | 0 | 5 | 5.2 | CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(C#N)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
CHEMBL207630 | 77145 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 590 | 9 | 0 | 5 | 5.2 | CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(C#N)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
9810893 | 103596 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 682 | 17 | 1 | 7 | 8.5 | CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCN3CCC)cc1 | 10.1021/jm0509703 | |||
CHEMBL3085307 | 103596 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 682 | 17 | 1 | 7 | 8.5 | CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCN3CCC)cc1 | 10.1021/jm0509703 | |||
CHEMBL5084989 | 217430 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | None | None | None | CC(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(C(=O)O)cc3)CC2)c2ccc(C)c(Cl)c2)CC1 | 10.1021/acs.jmedchem.1c00781 | |||||
57395817 | 69240 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 535 | 10 | 1 | 6 | 5.4 | COc1ccc(N(Cc2cccnc2)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926894 | 69240 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 535 | 10 | 1 | 6 | 5.4 | COc1ccc(N(Cc2cccnc2)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
72714078 | 92729 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 565 | 8 | 1 | 4 | 6.1 | Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435885 | 92729 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 565 | 8 | 1 | 4 | 6.1 | Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
72714079 | 92730 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 565 | 8 | 1 | 4 | 6.1 | Cc1cc(Cl)nc(C)c1C(=O)NCC[C@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435886 | 92730 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 565 | 8 | 1 | 4 | 6.1 | Cc1cc(Cl)nc(C)c1C(=O)NCC[C@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
49871007 | 58830 | None | 15 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 559 | 5 | 0 | 6 | 4.8 | CCO[C@@H]1Cc2cc(C(F)(F)F)ccc2[C@H]1N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C | 10.1021/ml1001536 | |||
CHEMBL1688243 | 58830 | None | 15 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 559 | 5 | 0 | 6 | 4.8 | CCO[C@@H]1Cc2cc(C(F)(F)F)ccc2[C@H]1N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C | 10.1021/ml1001536 | |||
44194588 | 10891 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 622 | 11 | 2 | 6 | 3.2 | C=CCN(C(=O)Cc1ccc(S(=O)(=O)NC)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172625 | 10891 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 622 | 11 | 2 | 6 | 3.2 | C=CCN(C(=O)Cc1ccc(S(=O)(=O)NC)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
57394057 | 69243 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 519 | 10 | 1 | 6 | 4.9 | COc1ccc(N(Cc2cccnc2)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(F)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926897 | 69243 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 519 | 10 | 1 | 6 | 4.9 | COc1ccc(N(Cc2cccnc2)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(F)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
49798089 | 10831 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 580 | 9 | 2 | 4 | 4.7 | C=CCN(C(=O)NCc1ccc(F)cc1F)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172050 | 10831 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 580 | 9 | 2 | 4 | 4.7 | C=CCN(C(=O)NCc1ccc(F)cc1F)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
49798090 | 10832 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 580 | 9 | 2 | 4 | 4.7 | C=CCN(C(=O)NCc1ccc(F)c(F)c1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172051 | 10832 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 580 | 9 | 2 | 4 | 4.7 | C=CCN(C(=O)NCc1ccc(F)c(F)c1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
50915506 | 19052 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 848 | 11 | 2 | 6 | 8.2 | CC(C)(C)NS(=O)(=O)c1cc(C(=O)N2CCC(CCN3CCC(N(C(=O)NCc4ccc(C#N)cc4)c4cccc(F)c4)CC3)(c3cccc(F)c3)CC2)c(Cl)cc1F | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288663 | 19052 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 848 | 11 | 2 | 6 | 8.2 | CC(C)(C)NS(=O)(=O)c1cc(C(=O)N2CCC(CCN3CCC(N(C(=O)NCc4ccc(C#N)cc4)c4cccc(F)c4)CC3)(c3cccc(F)c3)CC2)c(Cl)cc1F | 10.1016/j.bmcl.2010.10.033 | |||
49798085 | 10826 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 562 | 9 | 2 | 4 | 4.5 | C=CCN(C(=O)NCc1ccc(F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172045 | 10826 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 562 | 9 | 2 | 4 | 4.5 | C=CCN(C(=O)NCc1ccc(F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
72711741 | 92703 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 579 | 9 | 1 | 4 | 6.4 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(CC3CCCCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435859 | 92703 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 579 | 9 | 1 | 4 | 6.4 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(CC3CCCCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
11505350 | 168890 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 565 | 8 | 0 | 4 | 6.4 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(Sc3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
CHEMBL437494 | 168890 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 565 | 8 | 0 | 4 | 6.4 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(Sc3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
46225515 | 202111 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 551 | 6 | 0 | 5 | 4.1 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL592940 | 202111 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 551 | 6 | 0 | 5 | 4.1 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
172447334 | 195757 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 4060 | 155 | 47 | 57 | -9.1 | CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)c1ccc(S(=O)(=O)NC2CC3CCC(C2)N3CCCN(C(=O)C2CCN(C(C)=O)CC2)c2ccc(C)c(Cl)c2)cc1)C(N)=O)[C@@H](C)CC | 10.1016/j.ejmech.2023.115294 | |||
CHEMBL5410204 | 195757 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 4060 | 155 | 47 | 57 | -9.1 | CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)c1ccc(S(=O)(=O)NC2CC3CCC(C2)N3CCCN(C(=O)C2CCN(C(C)=O)CC2)c2ccc(C)c(Cl)c2)cc1)C(N)=O)[C@@H](C)CC | 10.1016/j.ejmech.2023.115294 | |||
3008904 | 202422 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 1 | 2 | ChEMBL | 537 | 6 | 0 | 5 | 5.0 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3cccc(C#N)c3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL59511 | 202422 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 1 | 2 | ChEMBL | 537 | 6 | 0 | 5 | 5.0 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3cccc(C#N)c3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
118727180 | 117448 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 592 | 8 | 0 | 5 | 4.2 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(S(=O)(=O)c3ccc(F)cc3)CC2C)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
CHEMBL3397991 | 117448 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 592 | 8 | 0 | 5 | 4.2 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(S(=O)(=O)c3ccc(F)cc3)CC2C)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
44511967 | 69234 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 516 | 10 | 1 | 7 | 4.5 | COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)ncnc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926888 | 69234 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 516 | 10 | 1 | 7 | 4.5 | COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)ncnc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
44511967 | 69234 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 516 | 10 | 1 | 7 | 4.5 | COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)ncnc3C)CC2)cc1 | 10.1021/ml2002604 | |||
CHEMBL1926888 | 69234 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 516 | 10 | 1 | 7 | 4.5 | COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)ncnc3C)CC2)cc1 | 10.1021/ml2002604 | |||
3008907 | 205124 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 405 | 4 | 1 | 3 | 4.9 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL61465 | 205124 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 405 | 4 | 1 | 3 | 4.9 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
505868 | 27787 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 488 | 8 | 0 | 4 | 5.6 | CCCN(c1ccccn1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL137072 | 27787 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 488 | 8 | 0 | 4 | 5.6 | CCCN(c1ccccn1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
44357072 | 98545 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 553 | 12 | 1 | 7 | 4.7 | CCCN(c1nccc(OC)n1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL275998 | 98545 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 553 | 12 | 1 | 7 | 4.7 | CCCN(c1nccc(OC)n1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
505878 | 119252 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 518 | 10 | 1 | 5 | 5.5 | CCCN(c1ccccn1)C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL343160 | 119252 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 518 | 10 | 1 | 5 | 5.5 | CCCN(c1ccccn1)C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
44356944 | 119283 | None | 1 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 509 | 10 | 1 | 6 | 4.3 | CCN(c1ncccn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL343366 | 119283 | None | 1 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 509 | 10 | 1 | 6 | 4.3 | CCN(c1ncccn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
44357078 | 119465 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 591 | 11 | 1 | 6 | 5.7 | CCCN(c1ncc(C(F)(F)F)cn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL344641 | 119465 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 591 | 11 | 1 | 6 | 5.7 | CCCN(c1ncc(C(F)(F)F)cn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
46225346 | 202498 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 551 | 7 | 1 | 6 | 3.2 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)(C)CO)CC3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL595570 | 202498 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 551 | 7 | 1 | 6 | 3.2 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)(C)CO)CC3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
46837554 | 10671 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 516 | 9 | 1 | 4 | 5.6 | COC(=O)C1(Cc2ccccc2)CCN(CC[C@H](NC(=O)C2CCC2)c2ccc(C(F)(F)F)cc2)CC1 | 10.1016/j.ejmech.2010.03.003 | |||
CHEMBL1170529 | 10671 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 516 | 9 | 1 | 4 | 5.6 | COC(=O)C1(Cc2ccccc2)CCN(CC[C@H](NC(=O)C2CCC2)c2ccc(C(F)(F)F)cc2)CC1 | 10.1016/j.ejmech.2010.03.003 | |||
46837425 | 103461 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 547 | 7 | 1 | 5 | 6.8 | Cc1nc2cccnc2n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)c1ccc(F)cc1)c1cccc2ccccc12 | 10.1016/j.ejmech.2010.03.003 | |||
CHEMBL3084746 | 103461 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 547 | 7 | 1 | 5 | 6.8 | Cc1nc2cccnc2n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)c1ccc(F)cc1)c1cccc2ccccc12 | 10.1016/j.ejmech.2010.03.003 | |||
53389085 | 66487 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 438 | 16 | 0 | 0 | 9.5 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL1817911 | 66487 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 438 | 16 | 0 | 0 | 9.5 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL1852138 | 66487 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 438 | 16 | 0 | 0 | 9.5 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL2057814 | 66487 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 438 | 16 | 0 | 0 | 9.5 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.bmcl.2012.05.127 | |||
53389085 | 66487 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 438 | 16 | 0 | 0 | 9.5 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL1817911 | 66487 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 438 | 16 | 0 | 0 | 9.5 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL1852138 | 66487 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 438 | 16 | 0 | 0 | 9.5 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL2057814 | 66487 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 438 | 16 | 0 | 0 | 9.5 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.ejmech.2012.07.049 | |||
46226118 | 14127 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 531 | 10 | 1 | 4 | 6.0 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccccc3)c1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL1198032 | 14127 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 531 | 10 | 1 | 4 | 6.0 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccccc3)c1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL593605 | 14127 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 531 | 10 | 1 | 4 | 6.0 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccccc3)c1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
44395365 | 124540 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 386 | 7 | 2 | 7 | 1.8 | CC(OC(=O)/C=C/c1ccc(O)cc1)C(=O)[C@H]1C[C@@H]1[C@H](O)[C@H]1CC=CC(=O)O1 | 10.1016/j.bmcl.2004.08.021 | |||
CHEMBL363999 | 124540 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 386 | 7 | 2 | 7 | 1.8 | CC(OC(=O)/C=C/c1ccc(O)cc1)C(=O)[C@H]1C[C@@H]1[C@H](O)[C@H]1CC=CC(=O)O1 | 10.1016/j.bmcl.2004.08.021 | |||
53389085 | 66487 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 438 | 16 | 0 | 0 | 9.5 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL1817911 | 66487 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 438 | 16 | 0 | 0 | 9.5 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL1852138 | 66487 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 438 | 16 | 0 | 0 | 9.5 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL2057814 | 66487 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 438 | 16 | 0 | 0 | 9.5 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.bmcl.2011.07.058 | |||
54752873 | 77204 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL2057812 | 77204 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL2078840 | 77204 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2012.05.127 | |||
54752873 | 77204 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL2057812 | 77204 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL2078840 | 77204 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
46225343 | 202597 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 521 | 6 | 0 | 5 | 3.8 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)C)CC3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL596299 | 202597 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 521 | 6 | 0 | 5 | 3.8 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)C)CC3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
3008911 | 101035 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 458 | 4 | 1 | 4 | 5.4 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3cccc4ccn(C)c34)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL294271 | 101035 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 458 | 4 | 1 | 4 | 5.4 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3cccc4ccn(C)c34)CC2)CC1 | 10.1021/jm031046g | |||
3008925 | 100968 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 492 | 5 | 1 | 3 | 6.5 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2cccc3[nH]ccc23)CC1 | 10.1021/jm031046g | |||
CHEMBL293900 | 100968 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 492 | 5 | 1 | 3 | 6.5 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2cccc3[nH]ccc23)CC1 | 10.1021/jm031046g | |||
90656325 | 111129 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 431 | 7 | 1 | 6 | 3.8 | CC(C)Oc1ccc(N2CCN(Cc3ccccc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.bmcl.2014.03.073 | |||
CHEMBL3263023 | 111129 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 431 | 7 | 1 | 6 | 3.8 | CC(C)Oc1ccc(N2CCN(Cc3ccccc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.bmcl.2014.03.073 | |||
70690766 | 77199 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 288 | 9 | 0 | 0 | 5.2 | CCCCCCCCCCc1c(C)cc(C)[n+]2c1CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL2064266 | 77199 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 288 | 9 | 0 | 0 | 5.2 | CCCCCCCCCCc1c(C)cc(C)[n+]2c1CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL2078746 | 77199 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 288 | 9 | 0 | 0 | 5.2 | CCCCCCCCCCc1c(C)cc(C)[n+]2c1CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
57397596 | 69226 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 646 | 12 | 2 | 6 | 7.6 | CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2ccccc2)c2ccc(Oc3ccc(C(=O)O)cc3)cc2)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926878 | 69226 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 646 | 12 | 2 | 6 | 7.6 | CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2ccccc2)c2ccc(Oc3ccc(C(=O)O)cc3)cc2)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
49798132 | 10735 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 547 | 9 | 1 | 4 | 4.4 | C=CCN(C(=O)Cc1ccc(F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1171029 | 10735 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 547 | 9 | 1 | 4 | 4.4 | C=CCN(C(=O)Cc1ccc(F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
52948296 | 19083 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 810 | 13 | 2 | 6 | 7.6 | CCCCN(C(=O)NCc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288924 | 19083 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 810 | 13 | 2 | 6 | 7.6 | CCCCN(C(=O)NCc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
44357379 | 28146 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 535 | 11 | 1 | 6 | 4.7 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(N(CC3CC3)c3ncccn3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL137327 | 28146 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 535 | 11 | 1 | 6 | 4.7 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(N(CC3CC3)c3ncccn3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00988-5 | |||
505869 | 28274 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 486 | 8 | 0 | 4 | 5.4 | C=CCN(c1ccccn1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL137419 | 28274 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 486 | 8 | 0 | 4 | 5.4 | C=CCN(c1ccccn1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
44357375 | 116067 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 523 | 11 | 1 | 6 | 4.7 | CCCN(c1cncnc1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL335562 | 116067 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 523 | 11 | 1 | 6 | 4.7 | CCCN(c1cncnc1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
9914742 | 166730 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 523 | 11 | 1 | 6 | 4.7 | CCCN(c1ncccn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL428104 | 166730 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 523 | 11 | 1 | 6 | 4.7 | CCCN(c1ncccn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
3008927 | 201314 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | -2 | 2 | ChEMBL | 482 | 5 | 0 | 4 | 6.0 | Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL58387 | 201314 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | -2 | 2 | ChEMBL | 482 | 5 | 0 | 4 | 6.0 | Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
53325460 | 58511 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | -2 | 2 | ChEMBL | 538 | 6 | 1 | 6 | 3.6 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@](CC(F)(F)F)(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)C1 | 10.1016/j.bmcl.2011.01.015 | |||
CHEMBL1683190 | 58511 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | -2 | 2 | ChEMBL | 538 | 6 | 1 | 6 | 3.6 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@](CC(F)(F)F)(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)C1 | 10.1016/j.bmcl.2011.01.015 | |||
3008934 | 201149 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 467 | 5 | 0 | 3 | 6.2 | Cc1cccc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL58101 | 201149 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 467 | 5 | 0 | 3 | 6.2 | Cc1cccc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
49864972 | 15791 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 640 | 11 | 2 | 6 | 3.3 | C=CCN(C(=O)Cc1ccc(S(=O)(=O)NC)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2010.05.046 | |||
CHEMBL1222770 | 15791 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 640 | 11 | 2 | 6 | 3.3 | C=CCN(C(=O)Cc1ccc(S(=O)(=O)NC)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2010.05.046 | |||
49864975 | 15794 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 695 | 11 | 2 | 6 | 4.3 | C=CCN(C(=O)NCc1ccc(S(=O)(=O)N(C)C)cc1)[C@@H]1C[C@@H]2CC[C@H](C1)N2C[C@H]1CN(C(=O)C2CCCC2)C[C@]1(O)c1cccc(F)c1 | 10.1016/j.bmcl.2010.05.046 | |||
CHEMBL1222773 | 15794 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 695 | 11 | 2 | 6 | 4.3 | C=CCN(C(=O)NCc1ccc(S(=O)(=O)N(C)C)cc1)[C@@H]1C[C@@H]2CC[C@H](C1)N2C[C@H]1CN(C(=O)C2CCCC2)C[C@]1(O)c1cccc(F)c1 | 10.1016/j.bmcl.2010.05.046 | |||
52943424 | 19072 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 833 | 12 | 2 | 7 | 6.8 | C=CCN(C(=O)Nc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288913 | 19072 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 833 | 12 | 2 | 7 | 6.8 | C=CCN(C(=O)Nc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
73346388 | 92722 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 566 | 8 | 1 | 4 | 6.6 | CNC(=O)c1ccc(Oc2ccc(CN3CCC(N4C(=O)N(C5CCCCC5)C[C@H]4c4ccccc4)CC3)cc2)cc1 | 10.1021/jm401101p | |||
CHEMBL2435878 | 92722 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 566 | 8 | 1 | 4 | 6.6 | CNC(=O)c1ccc(Oc2ccc(CN3CCC(N4C(=O)N(C5CCCCC5)C[C@H]4c4ccccc4)CC3)cc2)cc1 | 10.1021/jm401101p | |||
118727176 | 117444 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 542 | 8 | 0 | 4 | 5.0 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3cccc(F)c3)CC2C)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
CHEMBL3397987 | 117444 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 542 | 8 | 0 | 4 | 5.0 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3cccc(F)c3)CC2C)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
168279183 | 191020 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 541 | 9 | 1 | 8 | 5.2 | COC(=O)C1CCC(C(=O)N[C@@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)c2cccs2)CC1 | 10.1021/acs.jmedchem.2c01383 | |||
CHEMBL5185201 | 191020 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 541 | 9 | 1 | 8 | 5.2 | COC(=O)C1CCC(C(=O)N[C@@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)c2cccs2)CC1 | 10.1021/acs.jmedchem.2c01383 | |||
145967391 | 164344 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 589 | 7 | 0 | 5 | 6.9 | Cc1nc2cnccc2n1C1CCN(CCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)Cc3ccccc3)C2)CC1 | 10.1021/acs.jmedchem.8b00180 | |||
CHEMBL4211358 | 164344 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 589 | 7 | 0 | 5 | 6.9 | Cc1nc2cnccc2n1C1CCN(CCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)Cc3ccccc3)C2)CC1 | 10.1021/acs.jmedchem.8b00180 | |||
76327885 | 103458 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 418 | 6 | 0 | 6 | 4.3 | COC(=O)[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3cccnc31)C2)c1ccccc1 | 10.1016/j.bmcl.2010.02.023 | |||
CHEMBL3084729 | 103458 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 418 | 6 | 0 | 6 | 4.3 | COC(=O)[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3cccnc31)C2)c1ccccc1 | 10.1016/j.bmcl.2010.02.023 | |||
44194496 | 10822 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 587 | 9 | 1 | 8 | 4.3 | C=CCN(C(=O)OCc1ccc2nonc2c1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172041 | 10822 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 587 | 9 | 1 | 8 | 4.3 | C=CCN(C(=O)OCc1ccc2nonc2c1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
57397595 | 69225 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 581 | 10 | 1 | 5 | 5.8 | CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2ccccc2)c2ccc(C(=O)N(C)C)cc2)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926877 | 69225 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 581 | 10 | 1 | 5 | 5.8 | CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2ccccc2)c2ccc(C(=O)N(C)C)cc2)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
46225348 | 202628 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 515 | 6 | 0 | 5 | 3.8 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C4CCCC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL596519 | 202628 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 515 | 6 | 0 | 5 | 3.8 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C4CCCC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
3008936 | 201152 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 484 | 5 | 0 | 4 | 4.8 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL58109 | 201152 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 484 | 5 | 0 | 4 | 4.8 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
57401042 | 69233 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 560 | 9 | 1 | 6 | 5.8 | CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2cccc(C#N)c2)c2ccc(C#N)cc2)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926887 | 69233 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 560 | 9 | 1 | 6 | 5.8 | CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2cccc(C#N)c2)c2ccc(C#N)cc2)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
126567277 | 165736 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 553 | 8 | 1 | 6 | 6.7 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(Cl)s1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4243842 | 165736 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 553 | 8 | 1 | 6 | 6.7 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(Cl)s1 | 10.1021/acs.jmedchem.8b01077 | |||
3008930 | 201136 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 1 | 2 | ChEMBL | 499 | 5 | 0 | 5 | 4.6 | Cc1nc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL58004 | 201136 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 1 | 2 | ChEMBL | 499 | 5 | 0 | 5 | 4.6 | Cc1nc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
11527582 | 76455 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 664 | 10 | 1 | 5 | 5.9 | CC(C)(C)NC(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(S(C)(=O)=O)CC3)c3ccc(Cl)c(Cl)c3)CC2)cc1 | 10.1021/jm051034q | |||
CHEMBL205964 | 76455 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 664 | 10 | 1 | 5 | 5.9 | CC(C)(C)NC(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(S(C)(=O)=O)CC3)c3ccc(Cl)c(Cl)c3)CC2)cc1 | 10.1021/jm051034q | |||
505875 | 25983 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 487 | 8 | 0 | 5 | 4.8 | C=CCN(c1ncccn1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL135432 | 25983 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 487 | 8 | 0 | 5 | 4.8 | C=CCN(c1ncccn1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
505873 | 27954 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 486 | 8 | 0 | 4 | 5.4 | C=CCN(c1cccnc1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL137206 | 27954 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 486 | 8 | 0 | 4 | 5.4 | C=CCN(c1cccnc1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
3008913 | 102031 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | -1 | 2 | ChEMBL | 495 | 6 | 0 | 3 | 6.5 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL301454 | 102031 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | -1 | 2 | ChEMBL | 495 | 6 | 0 | 3 | 6.5 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
57395816 | 69238 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 535 | 10 | 1 | 6 | 5.4 | COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3cnc(Cl)cc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926892 | 69238 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 535 | 10 | 1 | 6 | 5.4 | COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3cnc(Cl)cc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
72712159 | 92711 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 493 | 6 | 0 | 2 | 7.1 | O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(-c3ccccc3)cc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435867 | 92711 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 493 | 6 | 0 | 2 | 7.1 | O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(-c3ccccc3)cc2)CC1 | 10.1021/jm401101p | |||
73352463 | 92690 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 553 | 8 | 1 | 4 | 7.0 | O=C(O)c1cccc(Oc2ccc(CN3CCC(N4C(=O)N(C5CCCCC5)C[C@H]4c4ccccc4)CC3)cc2)c1 | 10.1021/jm401101p | |||
CHEMBL2435846 | 92690 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 553 | 8 | 1 | 4 | 7.0 | O=C(O)c1cccc(Oc2ccc(CN3CCC(N4C(=O)N(C5CCCCC5)C[C@H]4c4ccccc4)CC3)cc2)c1 | 10.1021/jm401101p | |||
491775 | 12882 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1021/jm060051s | |||
CHEMBL1188807 | 12882 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1021/jm060051s | |||
CHEMBL537424 | 12882 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1021/jm060051s | |||
10117348 | 13932 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 455 | 8 | 1 | 4 | 4.1 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(OC)cc1)CC2 | 10.1021/jm060051s | |||
CHEMBL1196455 | 13932 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 455 | 8 | 1 | 4 | 4.1 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(OC)cc1)CC2 | 10.1021/jm060051s | |||
CHEMBL557015 | 13932 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 455 | 8 | 1 | 4 | 4.1 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(OC)cc1)CC2 | 10.1021/jm060051s | |||
10117348 | 13932 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 455 | 8 | 1 | 4 | 4.1 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(OC)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1196455 | 13932 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 455 | 8 | 1 | 4 | 4.1 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(OC)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL557015 | 13932 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 455 | 8 | 1 | 4 | 4.1 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(OC)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
10117348 | 13932 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 455 | 8 | 1 | 4 | 4.1 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(OC)cc1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL1196455 | 13932 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 455 | 8 | 1 | 4 | 4.1 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(OC)cc1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL557015 | 13932 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 455 | 8 | 1 | 4 | 4.1 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(OC)cc1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
16728326 | 10819 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 589 | 9 | 1 | 7 | 4.5 | C=CCN(C(=O)OCc1ccc2c(c1)OCO2)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172037 | 10819 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 589 | 9 | 1 | 7 | 4.5 | C=CCN(C(=O)OCc1ccc2c(c1)OCO2)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
76317388 | 104648 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 614 | 11 | 0 | 4 | 5.8 | CCN(CCc1ccc(Cl)cc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
CHEMBL3104693 | 104648 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 614 | 11 | 0 | 4 | 5.8 | CCN(CCc1ccc(Cl)cc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
CHEMBL5071060 | 216739 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | -3 | 2 | ChEMBL | None | None | None | Cc1nnc(C(C)C)n1C1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)cc1 | 10.1021/acs.jmedchem.1c00408 | |||||
89702731 | 109452 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | -3 | 2 | ChEMBL | 1197 | 28 | 7 | 15 | 6.6 | Cc1nnc(C(C)C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)cc1 | 10.1039/c3md00080j | |||
CHEMBL3219777 | 109452 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | -3 | 2 | ChEMBL | 1197 | 28 | 7 | 15 | 6.6 | Cc1nnc(C(C)C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)cc1 | 10.1039/c3md00080j | |||
162650661 | 180255 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | -3 | 2 | ChEMBL | 1197 | 28 | 7 | 15 | 6.6 | Cc1nnc(C(C)C)n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)cc1 | 10.1016/j.bmc.2016.09.059 | |||
CHEMBL4748891 | 180255 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | -3 | 2 | ChEMBL | 1197 | 28 | 7 | 15 | 6.6 | Cc1nnc(C(C)C)n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)cc1 | 10.1016/j.bmc.2016.09.059 | |||
89702731 | 109452 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | -3 | 2 | ChEMBL | 1197 | 28 | 7 | 15 | 6.6 | Cc1nnc(C(C)C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)cc1 | nan | |||
CHEMBL3219777 | 109452 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | -3 | 2 | ChEMBL | 1197 | 28 | 7 | 15 | 6.6 | Cc1nnc(C(C)C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)cc1 | nan | |||
CHEMBL5074037 | 216797 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | -1 | 2 | ChEMBL | None | None | None | CC(C)c1nnc(CCNC(=O)COCC(=O)NCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)n1C1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1 | 10.1021/acs.jmedchem.1c00408 | |||||
3008936 | 201152 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 484 | 5 | 0 | 4 | 4.8 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL58109 | 201152 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 484 | 5 | 0 | 4 | 4.8 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
122185609 | 122974 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 514 | 6 | 2 | 2 | 5.7 | Cc1c(CNC(=O)c2ccc3ccccc3c2)c(C)[n+]2c(c1CNC(=O)c1ccc3ccccc3c1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3604296 | 122974 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 514 | 6 | 2 | 2 | 5.7 | Cc1c(CNC(=O)c2ccc3ccccc3c2)c(C)[n+]2c(c1CNC(=O)c1ccc3ccccc3c1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3606029 | 122974 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 514 | 6 | 2 | 2 | 5.7 | Cc1c(CNC(=O)c2ccc3ccccc3c2)c(C)[n+]2c(c1CNC(=O)c1ccc3ccccc3c1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
162677279 | 183584 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 886 | 25 | 5 | 11 | 4.9 | CNC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)Nc1cccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)c1 | 10.1016/j.bmc.2016.09.059 | |||
CHEMBL4799343 | 183584 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 886 | 25 | 5 | 11 | 4.9 | CNC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)Nc1cccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)c1 | 10.1016/j.bmc.2016.09.059 | |||
46225344 | 202525 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 535 | 5 | 0 | 5 | 4.2 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)(C)C)CC3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL595760 | 202525 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 535 | 5 | 0 | 5 | 4.2 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)(C)C)CC3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
122185613 | 122982 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 578 | 8 | 2 | 2 | 7.5 | Cc1c(CNC(=O)c2ccc(C3CCCCC3)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(C3CCCCC3)cc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3604298 | 122982 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 578 | 8 | 2 | 2 | 7.5 | Cc1c(CNC(=O)c2ccc(C3CCCCC3)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(C3CCCCC3)cc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3606076 | 122982 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 578 | 8 | 2 | 2 | 7.5 | Cc1c(CNC(=O)c2ccc(C3CCCCC3)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(C3CCCCC3)cc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
21064283 | 14337 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 561 | 10 | 2 | 5 | 5.6 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL1170878 | 14337 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 561 | 10 | 2 | 5 | 5.6 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL1200019 | 14337 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 561 | 10 | 2 | 5 | 5.6 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
21064283 | 14337 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 561 | 10 | 2 | 5 | 5.6 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1170878 | 14337 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 561 | 10 | 2 | 5 | 5.6 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1200019 | 14337 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 561 | 10 | 2 | 5 | 5.6 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
46226132 | 14124 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 575 | 11 | 2 | 5 | 5.7 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(C(=O)O)cc3)c1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL1198014 | 14124 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 575 | 11 | 2 | 5 | 5.7 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(C(=O)O)cc3)c1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL593205 | 14124 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 575 | 11 | 2 | 5 | 5.7 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(C(=O)O)cc3)c1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
3002977 | 2460 | None | 43 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmc.2014.12.052 | |||
3002977.0 | 2460 | None | 43 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmc.2014.12.052 | |||
803 | 2460 | None | 43 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmc.2014.12.052 | |||
806 | 2460 | None | 43 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmc.2014.12.052 | |||
CHEMBL1201187 | 2460 | None | 43 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmc.2014.12.052 | |||
CHEMBL256907 | 2460 | None | 43 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmc.2014.12.052 | |||
CHEMBL584744 | 2460 | None | 43 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmc.2014.12.052 | |||
DB04835 | 2460 | None | 43 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmc.2014.12.052 | |||
3008930 | 201136 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 1 | 2 | ChEMBL | 499 | 5 | 0 | 5 | 4.6 | Cc1nc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL58004 | 201136 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 1 | 2 | ChEMBL | 499 | 5 | 0 | 5 | 4.6 | Cc1nc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
72713860 | 92757 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 532 | 8 | 1 | 5 | 4.9 | Cc1ncnc(C)c1C(=O)NCC[C@@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435913 | 92757 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 532 | 8 | 1 | 5 | 4.9 | Cc1ncnc(C)c1C(=O)NCC[C@@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
57395818 | 69249 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 548 | 10 | 1 | 7 | 4.2 | Cc1ccncc1CN(c1ccc([S+](C)[O-])cc1)C1CCN([C@H](C)CCNC(=O)c2c(C)ncnc2C)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926903 | 69249 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 548 | 10 | 1 | 7 | 4.2 | Cc1ccncc1CN(c1ccc([S+](C)[O-])cc1)C1CCN([C@H](C)CCNC(=O)c2c(C)ncnc2C)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
16728785 | 12834 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)[C@@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
CHEMBL1188408 | 12834 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)[C@@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
CHEMBL536298 | 12834 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)[C@@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
16728785 | 12834 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)[C@@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1188408 | 12834 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)[C@@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL536298 | 12834 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)[C@@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
21064293 | 14333 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 547 | 10 | 1 | 5 | 5.9 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(OC)cc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1170874 | 14333 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 547 | 10 | 1 | 5 | 5.9 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(OC)cc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1200015 | 14333 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 547 | 10 | 1 | 5 | 5.9 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(OC)cc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
46226126 | 14121 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 561 | 11 | 1 | 5 | 6.0 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(OC)cc3)c1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL1198011 | 14121 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 561 | 11 | 1 | 5 | 6.0 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(OC)cc3)c1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL593177 | 14121 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 561 | 11 | 1 | 5 | 6.0 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(OC)cc3)c1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
23577409 | 66439 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 563 | 10 | 3 | 6 | 4.2 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813439 | 66439 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 563 | 10 | 3 | 6 | 4.2 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851891 | 66439 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 563 | 10 | 3 | 6 | 4.2 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
162660215 | 181318 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | -79 | 2 | ChEMBL | 1197 | 28 | 7 | 15 | 6.6 | Cc1nnc(C(C)C)n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cccc(NC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)c1 | 10.1016/j.bmc.2016.09.059 | |||
CHEMBL4761273 | 181318 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | -79 | 2 | ChEMBL | 1197 | 28 | 7 | 15 | 6.6 | Cc1nnc(C(C)C)n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cccc(NC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)c1 | 10.1016/j.bmc.2016.09.059 | |||
122185641 | 122988 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 414 | 6 | 2 | 2 | 3.4 | Cc1c(CNC(=O)c2ccccc2)c(C)[n+]2c(c1CNC(=O)c1ccccc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3604312 | 122988 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 414 | 6 | 2 | 2 | 3.4 | Cc1c(CNC(=O)c2ccccc2)c(C)[n+]2c(c1CNC(=O)c1ccccc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3606113 | 122988 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 414 | 6 | 2 | 2 | 3.4 | Cc1c(CNC(=O)c2ccccc2)c(C)[n+]2c(c1CNC(=O)c1ccccc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
46225350 | 203615 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 515 | 7 | 0 | 5 | 3.8 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)CC4CCCC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL603325 | 203615 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 515 | 7 | 0 | 5 | 3.8 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)CC4CCCC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
70694942 | 77229 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 286 | 8 | 0 | 0 | 5.3 | CCCCCCCC/C=C/c1c(C)cc2[n+](c1C)CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL2064263 | 77229 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 286 | 8 | 0 | 0 | 5.3 | CCCCCCCC/C=C/c1c(C)cc2[n+](c1C)CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL2079186 | 77229 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | ChEMBL | 286 | 8 | 0 | 0 | 5.3 | CCCCCCCC/C=C/c1c(C)cc2[n+](c1C)CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
168283795 | 191002 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 586 | 10 | 2 | 9 | 4.2 | COc1ccc(S(N)(=O)=O)cc1C(=O)N[C@@H](CCN1[C@@H]2CC[C@H]1C[C@H](n1c(C)nnc1C(C)C)C2)c1cccs1 | 10.1021/acs.jmedchem.2c01383 | |||
CHEMBL5184978 | 191002 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 586 | 10 | 2 | 9 | 4.2 | COc1ccc(S(N)(=O)=O)cc1C(=O)N[C@@H](CCN1[C@@H]2CC[C@H]1C[C@H](n1c(C)nnc1C(C)C)C2)c1cccs1 | 10.1021/acs.jmedchem.2c01383 | |||
90666578 | 109455 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 528 | 8 | 2 | 6 | 5.5 | Cc1nnc(C(C)C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(N)cc1 | 10.1039/c3md00080j | |||
CHEMBL3219780 | 109455 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 528 | 8 | 2 | 6 | 5.5 | Cc1nnc(C(C)C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(N)cc1 | 10.1039/c3md00080j | |||
112500049 | 132553 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 642 | 11 | 2 | 7 | 6.7 | Cc1nnc(C(C)C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COC(C)(C)C)cc1 | nan | |||
CHEMBL3697626 | 132553 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 642 | 11 | 2 | 7 | 6.7 | Cc1nnc(C(C)C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COC(C)(C)C)cc1 | nan | |||
71458737 | 81813 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 563 | 9 | 2 | 6 | 5.2 | Cc1ccncc1CN(C(=O)Nc1cccnc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 | 10.1021/ml2002604 | |||
CHEMBL2164216 | 81813 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 563 | 9 | 2 | 6 | 5.2 | Cc1ccncc1CN(C(=O)Nc1cccnc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 | 10.1021/ml2002604 | |||
49864974 | 15797 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 656 | 9 | 2 | 4 | 6.1 | C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)[C@H]1C[C@@H]2CC[C@H](C1)N2C[C@H]1CN(C(=O)C2CCCC2)C[C@]1(O)c1cccc(F)c1 | 10.1016/j.bmcl.2010.05.046 | |||
CHEMBL1222776 | 15797 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 656 | 9 | 2 | 4 | 6.1 | C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)[C@H]1C[C@@H]2CC[C@H](C1)N2C[C@H]1CN(C(=O)C2CCCC2)C[C@]1(O)c1cccc(F)c1 | 10.1016/j.bmcl.2010.05.046 | |||
76316949 | 103460 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 511 | 8 | 1 | 5 | 5.5 | Cc1nc2cccnc2n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](C(=O)NCc1ccc(F)cc1)c1ccccc1 | 10.1016/j.bmcl.2010.02.023 | |||
CHEMBL3084731 | 103460 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 511 | 8 | 1 | 5 | 5.5 | Cc1nc2cccnc2n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](C(=O)NCc1ccc(F)cc1)c1ccccc1 | 10.1016/j.bmcl.2010.02.023 | |||
3008913 | 102031 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | -1 | 2 | ChEMBL | 495 | 6 | 0 | 3 | 6.5 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL301454 | 102031 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | -1 | 2 | ChEMBL | 495 | 6 | 0 | 3 | 6.5 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
3008917 | 205241 | None | 3 | Human | Functional | pIC50 | = | 7.8 | 7.8 | -6 | 2 | ChEMBL | 481 | 5 | 0 | 3 | 6.6 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL62152 | 205241 | None | 3 | Human | Functional | pIC50 | = | 7.8 | 7.8 | -6 | 2 | ChEMBL | 481 | 5 | 0 | 3 | 6.6 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
49798130 | 10872 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 559 | 10 | 1 | 5 | 4.3 | C=CCN(C(=O)Cc1ccc(OC)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172438 | 10872 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 559 | 10 | 1 | 5 | 4.3 | C=CCN(C(=O)Cc1ccc(OC)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
3008902 | 205137 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | -1 | 2 | ChEMBL | 512 | 6 | 0 | 4 | 5.1 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL61536 | 205137 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | -1 | 2 | ChEMBL | 512 | 6 | 0 | 4 | 5.1 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
3008902 | 205137 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | -1 | 2 | ChEMBL | 512 | 6 | 0 | 4 | 5.1 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL61536 | 205137 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | -1 | 2 | ChEMBL | 512 | 6 | 0 | 4 | 5.1 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
3008905 | 201174 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 537 | 6 | 0 | 5 | 5.0 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccc(C#N)cc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL58248 | 201174 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 537 | 6 | 0 | 5 | 5.0 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccc(C#N)cc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
23577386 | 66393 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 626 | 11 | 3 | 7 | 4.3 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(NS(C)(=O)=O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813435 | 66393 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 626 | 11 | 3 | 7 | 4.3 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(NS(C)(=O)=O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851672 | 66393 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 626 | 11 | 3 | 7 | 4.3 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(NS(C)(=O)=O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
52944616 | 19073 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 827 | 13 | 2 | 7 | 6.9 | C=CCN(C(=O)NCc1ccc(C(=O)OC)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288914 | 19073 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 827 | 13 | 2 | 7 | 6.9 | C=CCN(C(=O)NCc1ccc(C(=O)OC)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
72714077 | 92728 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 532 | 8 | 1 | 5 | 4.9 | Cc1ncnc(C)c1C(=O)NCC[C@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435884 | 92728 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 532 | 8 | 1 | 5 | 4.9 | Cc1ncnc(C)c1C(=O)NCC[C@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
3008911 | 101035 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 458 | 4 | 1 | 4 | 5.4 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3cccc4ccn(C)c34)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL294271 | 101035 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 458 | 4 | 1 | 4 | 5.4 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3cccc4ccn(C)c34)CC2)CC1 | 10.1021/jm031046g | |||
49798157 | 10888 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 597 | 9 | 1 | 4 | 5.3 | C=CCN(C(=O)Cc1ccc(C(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172622 | 10888 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 597 | 9 | 1 | 4 | 5.3 | C=CCN(C(=O)Cc1ccc(C(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
72711281 | 92745 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 547 | 8 | 1 | 6 | 4.6 | Cc1cccc(C2CN(C3CCCCC3)C(=O)N2C2CCN(C(C)CCNC(=O)c3c(C)ncnc3C)CC2)n1 | 10.1021/jm401101p | |||
CHEMBL2435901 | 92745 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 547 | 8 | 1 | 6 | 4.6 | Cc1cccc(C2CN(C3CCCCC3)C(=O)N2C2CCN(C(C)CCNC(=O)c3c(C)ncnc3C)CC2)n1 | 10.1021/jm401101p | |||
72711048 | 92737 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 550 | 8 | 1 | 5 | 5.0 | Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2cccc(F)c2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435893 | 92737 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 550 | 8 | 1 | 5 | 5.0 | Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2cccc(F)c2)CC1 | 10.1021/jm401101p | |||
52944586 | 19060 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 838 | 12 | 1 | 6 | 8.6 | C=CCN(C(=O)OCc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288873 | 19060 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 838 | 12 | 1 | 6 | 8.6 | C=CCN(C(=O)OCc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
46225347 | 202500 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 559 | 5 | 0 | 5 | 4.7 | Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)(C)C)CC3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL595584 | 202500 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 559 | 5 | 0 | 5 | 4.7 | Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)(C)C)CC3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
46225530 | 202123 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 550 | 6 | 0 | 4 | 4.7 | Cc1ccnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL592997 | 202123 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 550 | 6 | 0 | 4 | 4.7 | Cc1ccnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
122668134 | 190449 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 415 | 7 | 1 | 6 | 4.2 | CC(=O)N[C@@H](CCN1[C@@H]2CC[C@H]1C[C@H](n1c(C)nnc1C(C)C)C2)c1cccs1 | 10.1021/acs.jmedchem.2c01383 | |||
CHEMBL5176665 | 190449 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 415 | 7 | 1 | 6 | 4.2 | CC(=O)N[C@@H](CCN1[C@@H]2CC[C@H]1C[C@H](n1c(C)nnc1C(C)C)C2)c1cccs1 | 10.1021/acs.jmedchem.2c01383 | |||
118727172 | 117440 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 524 | 8 | 0 | 4 | 4.8 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccccc3)CC2C)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
CHEMBL3397983 | 117440 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 524 | 8 | 0 | 4 | 4.8 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccccc3)CC2C)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
72712373 | 92717 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 502 | 6 | 0 | 4 | 5.3 | O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(N3CCOCC3)cc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435873 | 92717 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 502 | 6 | 0 | 4 | 5.3 | O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(N3CCOCC3)cc2)CC1 | 10.1021/jm401101p | |||
3008917 | 205241 | None | 3 | Human | Functional | pIC50 | = | 7.8 | 7.8 | -6 | 2 | ChEMBL | 481 | 5 | 0 | 3 | 6.6 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL62152 | 205241 | None | 3 | Human | Functional | pIC50 | = | 7.8 | 7.8 | -6 | 2 | ChEMBL | 481 | 5 | 0 | 3 | 6.6 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
3008935 | 205186 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 468 | 5 | 0 | 4 | 5.6 | Cc1ccnc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL61828 | 205186 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 468 | 5 | 0 | 4 | 5.6 | Cc1ccnc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
3008914 | 203466 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 573 | 6 | 0 | 3 | 7.2 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccc(Br)cc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL60225 | 203466 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 573 | 6 | 0 | 3 | 7.2 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccc(Br)cc3)CC2)CC1 | 10.1021/jm031046g | |||
126567253 | 165607 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 537 | 8 | 1 | 6 | 6.2 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(F)s1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4240763 | 165607 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 537 | 8 | 1 | 6 | 6.2 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(F)s1 | 10.1021/acs.jmedchem.8b01077 | |||
72712597 | 92720 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 474 | 6 | 1 | 3 | 4.8 | CNC(=O)c1ccc(CN2CCC(N3C(=O)N(C4CCCCC4)C[C@H]3c3ccccc3)CC2)cc1 | 10.1021/jm401101p | |||
CHEMBL2435876 | 92720 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 474 | 6 | 1 | 3 | 4.8 | CNC(=O)c1ccc(CN2CCC(N3C(=O)N(C4CCCCC4)C[C@H]3c3ccccc3)CC2)cc1 | 10.1021/jm401101p | |||
122668182 | 190357 | None | 2 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 573 | 7 | 1 | 6 | 5.4 | CC(=O)N1CCc2c(nc(C)n2[C@@H]2C[C@H]3CC[C@@H](C2)N3CC[C@H](NC(=O)C2CCC(F)(F)CC2)c2ccsc2)C1 | 10.1021/acs.jmedchem.2c01383 | |||
CHEMBL5175220 | 190357 | None | 2 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 573 | 7 | 1 | 6 | 5.4 | CC(=O)N1CCc2c(nc(C)n2[C@@H]2C[C@H]3CC[C@@H](C2)N3CC[C@H](NC(=O)C2CCC(F)(F)CC2)c2ccsc2)C1 | 10.1021/acs.jmedchem.2c01383 | |||
52943426 | 19082 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 751 | 13 | 1 | 6 | 6.1 | C=CCN(C(=O)CCc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288923 | 19082 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 751 | 13 | 1 | 6 | 6.1 | C=CCN(C(=O)CCc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
16728786 | 13974 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 493 | 9 | 2 | 5 | 4.0 | CCCCN1C(=O)[C@H]([C@@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
CHEMBL1196759 | 13974 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 493 | 9 | 2 | 5 | 4.0 | CCCCN1C(=O)[C@H]([C@@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
CHEMBL558043 | 13974 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 493 | 9 | 2 | 5 | 4.0 | CCCCN1C(=O)[C@H]([C@@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
76310165 | 104647 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 598 | 11 | 0 | 4 | 5.3 | CCN(CCc1ccc(F)cc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
CHEMBL3104692 | 104647 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 598 | 11 | 0 | 4 | 5.3 | CCN(CCc1ccc(F)cc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
56673134 | 66462 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 442 | 18 | 0 | 0 | 9.3 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL1817913 | 66462 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 442 | 18 | 0 | 0 | 9.3 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL1852005 | 66462 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 442 | 18 | 0 | 0 | 9.3 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL2057818 | 66462 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 442 | 18 | 0 | 0 | 9.3 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.bmcl.2012.05.127 | |||
56673134 | 66462 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 442 | 18 | 0 | 0 | 9.3 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL1817913 | 66462 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 442 | 18 | 0 | 0 | 9.3 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL1852005 | 66462 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 442 | 18 | 0 | 0 | 9.3 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL2057818 | 66462 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 442 | 18 | 0 | 0 | 9.3 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.bmcl.2011.07.058 | |||
72714319 | 92733 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 566 | 8 | 1 | 5 | 5.5 | Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccccc2Cl)CC1 | 10.1021/jm401101p | |||
CHEMBL2435889 | 92733 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 566 | 8 | 1 | 5 | 5.5 | Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccccc2Cl)CC1 | 10.1021/jm401101p | |||
72711050 | 92739 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 590 | 9 | 1 | 7 | 4.7 | COC(=O)c1cccc(C2CN(C3CCCCC3)C(=O)N2C2CCN(C(C)CCNC(=O)c3c(C)ncnc3C)CC2)c1 | 10.1021/jm401101p | |||
CHEMBL2435895 | 92739 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 590 | 9 | 1 | 7 | 4.7 | COC(=O)c1cccc(C2CN(C3CCCCC3)C(=O)N2C2CCN(C(C)CCNC(=O)c3c(C)ncnc3C)CC2)c1 | 10.1021/jm401101p | |||
90666579 | 109456 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 628 | 9 | 2 | 7 | 7.3 | Cc1nnc(C(C)C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)OC(C)(C)C)cc1 | 10.1039/c3md00080j | |||
CHEMBL3219781 | 109456 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 628 | 9 | 2 | 7 | 7.3 | Cc1nnc(C(C)C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)OC(C)(C)C)cc1 | 10.1039/c3md00080j | |||
57397603 | 69252 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 604 | 10 | 1 | 7 | 5.6 | Cc1ccncc1CN(c1ccc(N2CCOCC2)cc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1927007 | 69252 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 604 | 10 | 1 | 7 | 5.6 | Cc1ccncc1CN(c1ccc(N2CCOCC2)cc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
72712375 | 92719 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 514 | 6 | 0 | 3 | 6.5 | Cc1ccccc1N1CCC(CN2CCC(N3C(=O)N(C4CCCCC4)C[C@H]3c3ccccc3)CC2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435875 | 92719 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 514 | 6 | 0 | 3 | 6.5 | Cc1ccccc1N1CCC(CN2CCC(N3C(=O)N(C4CCCCC4)C[C@H]3c3ccccc3)CC2)CC1 | 10.1021/jm401101p | |||
49871007 | 58830 | None | 15 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 559 | 5 | 0 | 6 | 4.8 | CCO[C@@H]1Cc2cc(C(F)(F)F)ccc2[C@H]1N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C | 10.1021/ml1001536 | |||
CHEMBL1688243 | 58830 | None | 15 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 559 | 5 | 0 | 6 | 4.8 | CCO[C@@H]1Cc2cc(C(F)(F)F)ccc2[C@H]1N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C | 10.1021/ml1001536 | |||
3008929 | 198093 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | -1 | 2 | ChEMBL | 498 | 5 | 0 | 4 | 5.2 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL556314 | 198093 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | -1 | 2 | ChEMBL | 498 | 5 | 0 | 4 | 5.2 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
145983513 | 165655 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 457 | 8 | 1 | 6 | 5.2 | Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)C(C)C)s1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4242034 | 165655 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 457 | 8 | 1 | 6 | 5.2 | Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)C(C)C)s1 | 10.1021/acs.jmedchem.8b01077 | |||
10278617 | 95235 | None | 3 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 499 | 5 | 0 | 5 | 4.6 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1 | 10.1016/j.bmcl.2008.01.108 | |||
CHEMBL255858 | 95235 | None | 3 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 499 | 5 | 0 | 5 | 4.6 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1 | 10.1016/j.bmcl.2008.01.108 | |||
3008931 | 205104 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 559 | 6 | 0 | 5 | 7.1 | Cc1nc(-c2ccccc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL61374 | 205104 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 559 | 6 | 0 | 5 | 7.1 | Cc1nc(-c2ccccc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
464990 | 14390 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 491 | 8 | 2 | 4 | 4.5 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1c[nH]c(-c3ccccc3)n1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1200254 | 14390 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 491 | 8 | 2 | 4 | 4.5 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1c[nH]c(-c3ccccc3)n1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL3216057 | 14390 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 491 | 8 | 2 | 4 | 4.5 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1c[nH]c(-c3ccccc3)n1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
46225343 | 202597 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 521 | 6 | 0 | 5 | 3.8 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)C)CC3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL596299 | 202597 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 521 | 6 | 0 | 5 | 3.8 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)C)CC3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
118727191 | 117459 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 535 | 7 | 0 | 5 | 4.7 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(c3ccc(C#N)cc3)CC2C)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
CHEMBL3398002 | 117459 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 535 | 7 | 0 | 5 | 4.7 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(c3ccc(C#N)cc3)CC2C)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
62707284 | 77218 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 286 | 8 | 0 | 0 | 5.3 | CCCCCCCC/C=C\c1c(C)cc2[n+](c1C)CCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL2057807 | 77218 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 286 | 8 | 0 | 0 | 5.3 | CCCCCCCC/C=C\c1c(C)cc2[n+](c1C)CCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL2079027 | 77218 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 286 | 8 | 0 | 0 | 5.3 | CCCCCCCC/C=C\c1c(C)cc2[n+](c1C)CCC2 | 10.1016/j.bmcl.2012.05.127 | |||
62707284 | 77218 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 286 | 8 | 0 | 0 | 5.3 | CCCCCCCC/C=C\c1c(C)cc2[n+](c1C)CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL2057807 | 77218 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 286 | 8 | 0 | 0 | 5.3 | CCCCCCCC/C=C\c1c(C)cc2[n+](c1C)CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL2079027 | 77218 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 286 | 8 | 0 | 0 | 5.3 | CCCCCCCC/C=C\c1c(C)cc2[n+](c1C)CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
70688700 | 77225 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 288 | 9 | 0 | 0 | 5.2 | CCCCCCCCCCc1c(C)cc2[n+](c1C)CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL2064264 | 77225 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 288 | 9 | 0 | 0 | 5.2 | CCCCCCCCCCc1c(C)cc2[n+](c1C)CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL2079127 | 77225 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 288 | 9 | 0 | 0 | 5.2 | CCCCCCCCCCc1c(C)cc2[n+](c1C)CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
46225346 | 202498 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 551 | 7 | 1 | 6 | 3.2 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)(C)CO)CC3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL595570 | 202498 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 551 | 7 | 1 | 6 | 3.2 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)(C)CO)CC3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
46225529 | 202151 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 591 | 6 | 0 | 5 | 4.3 | Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL593195 | 202151 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 591 | 6 | 0 | 5 | 4.3 | Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
3008912 | 203529 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 458 | 4 | 1 | 4 | 5.4 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc4ccn(C)c4c3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL60279 | 203529 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 458 | 4 | 1 | 4 | 5.4 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc4ccn(C)c4c3)CC2)CC1 | 10.1021/jm031046g | |||
90656328 | 111130 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 476 | 8 | 1 | 8 | 3.7 | CC(C)Oc1ccc(N2CCN(Cc3ccccc3[N+](=O)[O-])CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.bmcl.2014.03.073 | |||
CHEMBL3263025 | 111130 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 476 | 8 | 1 | 8 | 3.7 | CC(C)Oc1ccc(N2CCN(Cc3ccccc3[N+](=O)[O-])CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.bmcl.2014.03.073 | |||
72712160 | 92713 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 495 | 6 | 0 | 4 | 5.9 | O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(-c3ncccn3)cc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435869 | 92713 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 495 | 6 | 0 | 4 | 5.9 | O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(-c3ncccn3)cc2)CC1 | 10.1021/jm401101p | |||
52943389 | 19063 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 848 | 13 | 1 | 8 | 7.0 | C=CCN(C(=O)OCc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288876 | 19063 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 848 | 13 | 1 | 8 | 7.0 | C=CCN(C(=O)OCc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
46191233 | 202126 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 575 | 6 | 0 | 5 | 4.6 | Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL593027 | 202126 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 575 | 6 | 0 | 5 | 4.6 | Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
118727184 | 117452 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 578 | 9 | 0 | 5 | 4.4 | Cc1ccc(N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)C(=O)C2CCN(S(C)(=O)=O)CC2)cc1Cl | 10.1016/j.bmc.2014.12.052 | |||
CHEMBL3397995 | 117452 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 578 | 9 | 0 | 5 | 4.4 | Cc1ccc(N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)C(=O)C2CCN(S(C)(=O)=O)CC2)cc1Cl | 10.1016/j.bmc.2014.12.052 | |||
15950679 | 92712 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 495 | 6 | 0 | 4 | 5.9 | O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(-c3cncnc3)cc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435868 | 92712 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 495 | 6 | 0 | 4 | 5.9 | O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(-c3cncnc3)cc2)CC1 | 10.1021/jm401101p | |||
49798156 | 10577 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 607 | 9 | 1 | 4 | 5.0 | C=CCN(C(=O)Cc1ccc(Br)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1169819 | 10577 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 607 | 9 | 1 | 4 | 5.0 | C=CCN(C(=O)Cc1ccc(Br)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
72712161 | 92714 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 494 | 6 | 0 | 3 | 6.5 | O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(-c3cccnc3)cc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435870 | 92714 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 494 | 6 | 0 | 3 | 6.5 | O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(-c3cccnc3)cc2)CC1 | 10.1021/jm401101p | |||
10280945 | 12844 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 517 | 9 | 1 | 4 | 5.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1021/jm060051s | |||
CHEMBL1188557 | 12844 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 517 | 9 | 1 | 4 | 5.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1021/jm060051s | |||
CHEMBL536743 | 12844 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 517 | 9 | 1 | 4 | 5.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1021/jm060051s | |||
10277467 | 13089 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 443 | 7 | 1 | 5 | 3.0 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc3c(c1)OCCO3)CC2 | 10.1021/jm060051s | |||
CHEMBL1190217 | 13089 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 443 | 7 | 1 | 5 | 3.0 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc3c(c1)OCCO3)CC2 | 10.1021/jm060051s | |||
CHEMBL540366 | 13089 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 443 | 7 | 1 | 5 | 3.0 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc3c(c1)OCCO3)CC2 | 10.1021/jm060051s | |||
21064331 | 14382 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 533 | 9 | 1 | 4 | 6.3 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Sc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1172871 | 14382 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 533 | 9 | 1 | 4 | 6.3 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Sc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1200224 | 14382 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 533 | 9 | 1 | 4 | 6.3 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Sc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
46226120 | 14151 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 547 | 10 | 1 | 4 | 6.3 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Sc3ccccc3)c1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL1198114 | 14151 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 547 | 10 | 1 | 4 | 6.3 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Sc3ccccc3)c1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL596165 | 14151 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 547 | 10 | 1 | 4 | 6.3 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Sc3ccccc3)c1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
122185611 | 122976 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 566 | 8 | 2 | 2 | 6.7 | Cc1c(CNC(=O)c2ccc(-c3ccccc3)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(-c3ccccc3)cc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3604297 | 122976 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 566 | 8 | 2 | 2 | 6.7 | Cc1c(CNC(=O)c2ccc(-c3ccccc3)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(-c3ccccc3)cc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3606030 | 122976 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | ChEMBL | 566 | 8 | 2 | 2 | 6.7 | Cc1c(CNC(=O)c2ccc(-c3ccccc3)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(-c3ccccc3)cc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
52945865 | 19079 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 838 | 13 | 1 | 6 | 7.9 | C=CCN(C(=O)Cc1ccc(OC(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288920 | 19079 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 838 | 13 | 1 | 6 | 7.9 | C=CCN(C(=O)Cc1ccc(OC(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
168271219 | 190539 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 483 | 8 | 1 | 6 | 5.7 | Cc1ccsc1[C@H](CCN1[C@@H]2CC[C@H]1C[C@H](n1c(C)nnc1C(C)C)C2)NC(=O)C1CCCC1 | 10.1021/acs.jmedchem.2c01383 | |||
CHEMBL5178121 | 190539 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 483 | 8 | 1 | 6 | 5.7 | Cc1ccsc1[C@H](CCN1[C@@H]2CC[C@H]1C[C@H](n1c(C)nnc1C(C)C)C2)NC(=O)C1CCCC1 | 10.1021/acs.jmedchem.2c01383 | |||
11237537 | 192207 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 509 | 7 | 1 | 5 | 4.3 | CC(=O)N[C@@H](CCN1C2CCC1CC(n1c(C)nc3c1CCN(C(=O)C(C)C)C3)C2)c1cccc(F)c1 | 10.1021/acs.jmedchem.2c01383 | |||
CHEMBL5203084 | 192207 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 509 | 7 | 1 | 5 | 4.3 | CC(=O)N[C@@H](CCN1C2CCC1CC(n1c(C)nc3c1CCN(C(=O)C(C)C)C3)C2)c1cccc(F)c1 | 10.1021/acs.jmedchem.2c01383 | |||
10277467 | 13089 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 443 | 7 | 1 | 5 | 3.0 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc3c(c1)OCCO3)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL1190217 | 13089 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 443 | 7 | 1 | 5 | 3.0 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc3c(c1)OCCO3)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL540366 | 13089 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 443 | 7 | 1 | 5 | 3.0 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc3c(c1)OCCO3)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
53324598 | 60132 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL1668020 | 60132 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL1739382 | 60132 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
46225512 | 204057 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 489 | 5 | 0 | 5 | 3.3 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C(C)(C)C)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL605727 | 204057 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 489 | 5 | 0 | 5 | 3.3 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C(C)(C)C)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
122185639 | 122987 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 442 | 6 | 2 | 2 | 4.0 | Cc1ccc(C(=O)NCc2c(C)c(CNC(=O)c3ccc(C)cc3)c3[n+](c2C)CCC3)cc1 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3604311 | 122987 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 442 | 6 | 2 | 2 | 4.0 | Cc1ccc(C(=O)NCc2c(C)c(CNC(=O)c3ccc(C)cc3)c3[n+](c2C)CCC3)cc1 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3606112 | 122987 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 442 | 6 | 2 | 2 | 4.0 | Cc1ccc(C(=O)NCc2c(C)c(CNC(=O)c3ccc(C)cc3)c3[n+](c2C)CCC3)cc1 | 10.1016/j.bmcl.2015.06.029 | |||
11466794 | 69223 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 535 | 9 | 1 | 5 | 5.9 | CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2ccccc2)c2ccc(C#N)cc2)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926875 | 69223 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 535 | 9 | 1 | 5 | 5.9 | CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2ccccc2)c2ccc(C#N)cc2)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
172449421 | 195963 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 3969 | 154 | 46 | 55 | -8.1 | CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(C(C)=O)CC3)c3ccc(C)c(Cl)c3)CC2)cc1)C(N)=O)[C@@H](C)CC | 10.1016/j.ejmech.2023.115294 | |||
CHEMBL5414303 | 195963 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 3969 | 154 | 46 | 55 | -8.1 | CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(C(C)=O)CC3)c3ccc(C)c(Cl)c3)CC2)cc1)C(N)=O)[C@@H](C)CC | 10.1016/j.ejmech.2023.115294 | |||
122185633 | 122984 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 506 | 8 | 2 | 4 | 4.8 | CSc1ccc(C(=O)NCc2c(C)c(CNC(=O)c3ccc(SC)cc3)c3[n+](c2C)CCC3)cc1 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3604308 | 122984 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 506 | 8 | 2 | 4 | 4.8 | CSc1ccc(C(=O)NCc2c(C)c(CNC(=O)c3ccc(SC)cc3)c3[n+](c2C)CCC3)cc1 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3606102 | 122984 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 506 | 8 | 2 | 4 | 4.8 | CSc1ccc(C(=O)NCc2c(C)c(CNC(=O)c3ccc(SC)cc3)c3[n+](c2C)CCC3)cc1 | 10.1016/j.bmcl.2015.06.029 | |||
46225428 | 202397 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 503 | 5 | 0 | 5 | 3.7 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C(C)(C)C)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL594914 | 202397 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 503 | 5 | 0 | 5 | 3.7 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C(C)(C)C)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
76335572 | 104644 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 570 | 10 | 1 | 4 | 4.5 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCCc3ccc(F)cc3)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
CHEMBL3104689 | 104644 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 570 | 10 | 1 | 4 | 4.5 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCCc3ccc(F)cc3)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
90656340 | 111191 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 461 | 8 | 1 | 7 | 3.8 | COc1ccc(CN2CCN(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 | 10.1016/j.bmcl.2014.03.073 | |||
CHEMBL3263319 | 111191 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 461 | 8 | 1 | 7 | 3.8 | COc1ccc(CN2CCN(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 | 10.1016/j.bmcl.2014.03.073 | |||
57402800 | 69231 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 565 | 10 | 1 | 6 | 5.9 | COc1ccc(N(Cc2cccc(C#N)c2)C2CCN(C(C)CCNC(=O)c3c(Cl)cncc3Cl)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926885 | 69231 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 565 | 10 | 1 | 6 | 5.9 | COc1ccc(N(Cc2cccc(C#N)c2)C2CCN(C(C)CCNC(=O)c3c(Cl)cncc3Cl)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
53319405 | 57219 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 499 | 7 | 1 | 6 | 2.9 | CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(S(C)(=O)=O)CC3)C2)c1ccccc1 | 10.1021/jm100978n | |||
CHEMBL1649918 | 57219 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 499 | 7 | 1 | 6 | 2.9 | CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(S(C)(=O)=O)CC3)C2)c1ccccc1 | 10.1021/jm100978n | |||
46191232 | 202130 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 618 | 6 | 0 | 4 | 5.7 | Cc1cc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL593046 | 202130 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 618 | 6 | 0 | 4 | 5.7 | Cc1cc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
3008902 | 205137 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | -1 | 2 | ChEMBL | 512 | 6 | 0 | 4 | 5.1 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL61536 | 205137 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | -1 | 2 | ChEMBL | 512 | 6 | 0 | 4 | 5.1 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
3008908 | 205125 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 439 | 4 | 1 | 3 | 5.5 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(Cl)cc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL61466 | 205125 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 439 | 4 | 1 | 3 | 5.5 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(Cl)cc3)CC2)CC1 | 10.1021/jm031046g | |||
11570778 | 141006 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 608 | 10 | 1 | 5 | 4.4 | CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3cccc(C(N)=O)c3)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
CHEMBL382252 | 141006 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 608 | 10 | 1 | 5 | 4.4 | CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3cccc(C(N)=O)c3)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
44194589 | 10890 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 608 | 10 | 2 | 6 | 2.9 | C=CCN(C(=O)Cc1ccc(S(N)(=O)=O)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172624 | 10890 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 608 | 10 | 2 | 6 | 2.9 | C=CCN(C(=O)Cc1ccc(S(N)(=O)=O)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
3002977 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmc.2016.09.059 | |||
3002977.0 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmc.2016.09.059 | |||
803 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmc.2016.09.059 | |||
806 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmc.2016.09.059 | |||
CHEMBL1201187 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmc.2016.09.059 | |||
CHEMBL256907 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmc.2016.09.059 | |||
CHEMBL584744 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmc.2016.09.059 | |||
DB04835 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmc.2016.09.059 | |||
3013689 | 77069 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 583 | 9 | 0 | 4 | 5.5 | CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
CHEMBL207190 | 77069 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 583 | 9 | 0 | 4 | 5.5 | CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
11700429 | 103600 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 710 | 17 | 1 | 7 | 9.1 | CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCCN3CC(C)C)cc1 | 10.1021/jm0509703 | |||
CHEMBL3085311 | 103600 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 710 | 17 | 1 | 7 | 9.1 | CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCCN3CC(C)C)cc1 | 10.1021/jm0509703 | |||
3002977 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1039/c3md00080j | |||
3002977.0 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1039/c3md00080j | |||
803 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1039/c3md00080j | |||
806 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1039/c3md00080j | |||
CHEMBL1201187 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1039/c3md00080j | |||
CHEMBL256907 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1039/c3md00080j | |||
CHEMBL584744 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1039/c3md00080j | |||
DB04835 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1039/c3md00080j | |||
457871 | 100777 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 483 | 4 | 1 | 3 | 5.6 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(Br)cc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL292625 | 100777 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 483 | 4 | 1 | 3 | 5.6 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(Br)cc3)CC2)CC1 | 10.1021/jm031046g | |||
3008928 | 205114 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | -1 | 2 | ChEMBL | 483 | 5 | 0 | 5 | 5.4 | Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL61424 | 205114 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | -1 | 2 | ChEMBL | 483 | 5 | 0 | 5 | 5.4 | Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
3002977 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | nan | |||
3002977.0 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | nan | |||
803 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | nan | |||
806 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | nan | |||
CHEMBL1201187 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | nan | |||
CHEMBL256907 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | nan | |||
CHEMBL584744 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | nan | |||
DB04835 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | nan | |||
5275765 | 138321 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 572 | 9 | 1 | 4 | 5.0 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(C(N)=O)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
CHEMBL377026 | 138321 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 572 | 9 | 1 | 4 | 5.0 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(C(N)=O)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
145984727 | 165662 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 483 | 8 | 1 | 6 | 5.8 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCCCC1)c1cccs1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4242114 | 165662 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 483 | 8 | 1 | 6 | 5.8 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCCCC1)c1cccs1 | 10.1021/acs.jmedchem.8b01077 | |||
145986021 | 165892 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 505 | 8 | 1 | 6 | 5.6 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)C1)c1cccs1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4248009 | 165892 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 505 | 8 | 1 | 6 | 5.6 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)C1)c1cccs1 | 10.1021/acs.jmedchem.8b01077 | |||
59458103 | 92750 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 537 | 8 | 1 | 4 | 5.4 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435906 | 92750 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 537 | 8 | 1 | 4 | 5.4 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
3008927 | 201314 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | -2 | 2 | ChEMBL | 482 | 5 | 0 | 4 | 6.0 | Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL58387 | 201314 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | -2 | 2 | ChEMBL | 482 | 5 | 0 | 4 | 6.0 | Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
3008914 | 203466 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 573 | 6 | 0 | 3 | 7.2 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccc(Br)cc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL60225 | 203466 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 573 | 6 | 0 | 3 | 7.2 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccc(Br)cc3)CC2)CC1 | 10.1021/jm031046g | |||
11513274 | 103598 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 734 | 17 | 1 | 9 | 8.0 | CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCN3Cc2cnn(C)c2)cc1 | 10.1021/jm0509703 | |||
CHEMBL3085309 | 103598 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 734 | 17 | 1 | 9 | 8.0 | CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCN3Cc2cnn(C)c2)cc1 | 10.1021/jm0509703 | |||
57397598 | 69236 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 515 | 10 | 1 | 6 | 5.1 | COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)ccnc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926890 | 69236 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 515 | 10 | 1 | 6 | 5.1 | COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)ccnc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
59458247 | 92756 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 571 | 8 | 1 | 5 | 6.2 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccsc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435912 | 92756 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 571 | 8 | 1 | 5 | 6.2 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccsc2)CC1 | 10.1021/jm401101p | |||
3008923 | 201355 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 521 | 5 | 0 | 3 | 7.3 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2c(Cl)cccc2Cl)CC1 | 10.1021/jm031046g | |||
CHEMBL58441 | 201355 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 521 | 5 | 0 | 3 | 7.3 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2c(Cl)cccc2Cl)CC1 | 10.1021/jm031046g | |||
3008908 | 205125 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 439 | 4 | 1 | 3 | 5.5 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(Cl)cc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL61466 | 205125 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 439 | 4 | 1 | 3 | 5.5 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(Cl)cc3)CC2)CC1 | 10.1021/jm031046g | |||
168268916 | 190113 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 549 | 10 | 1 | 7 | 5.9 | COCc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccsc1 | 10.1021/acs.jmedchem.2c01383 | |||
CHEMBL5171331 | 190113 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 549 | 10 | 1 | 7 | 5.9 | COCc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccsc1 | 10.1021/acs.jmedchem.2c01383 | |||
122668213 | 165678 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 483 | 8 | 1 | 6 | 5.7 | Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCCC2)s1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4242489 | 165678 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 483 | 8 | 1 | 6 | 5.7 | Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCCC2)s1 | 10.1021/acs.jmedchem.8b01077 | |||
145984502 | 165698 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 517 | 8 | 1 | 6 | 5.8 | Cc1nnc(C2CC2)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccsc1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4242913 | 165698 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 517 | 8 | 1 | 6 | 5.8 | Cc1nnc(C2CC2)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccsc1 | 10.1021/acs.jmedchem.8b01077 | |||
145984829 | 165913 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 491 | 8 | 1 | 6 | 5.2 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CC(F)(F)C1)c1cccs1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4248472 | 165913 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 491 | 8 | 1 | 6 | 5.2 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CC(F)(F)C1)c1cccs1 | 10.1021/acs.jmedchem.8b01077 | |||
52948296 | 19083 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 810 | 13 | 2 | 6 | 7.6 | CCCCN(C(=O)NCc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288924 | 19083 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 810 | 13 | 2 | 6 | 7.6 | CCCCN(C(=O)NCc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
3008917 | 205241 | None | 3 | Human | Functional | pIC50 | = | 8.6 | 8.6 | -6 | 2 | ChEMBL | 481 | 5 | 0 | 3 | 6.6 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL62152 | 205241 | None | 3 | Human | Functional | pIC50 | = | 8.6 | 8.6 | -6 | 2 | ChEMBL | 481 | 5 | 0 | 3 | 6.6 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
49798086 | 10827 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 578 | 9 | 2 | 4 | 5.0 | C=CCN(C(=O)NCc1ccc(Cl)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172046 | 10827 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 578 | 9 | 2 | 4 | 5.0 | C=CCN(C(=O)NCc1ccc(Cl)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
11577846 | 77149 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 581 | 8 | 0 | 4 | 5.4 | CC(=O)N1CCC(C(=O)N(CCCN2CCC([S+]([O-])c3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
CHEMBL207654 | 77149 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 581 | 8 | 0 | 4 | 5.4 | CC(=O)N1CCC(C(=O)N(CCCN2CCC([S+]([O-])c3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
145985461 | 165593 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 505 | 8 | 1 | 6 | 5.5 | CCc1nnc(C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccsc1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4240475 | 165593 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 505 | 8 | 1 | 6 | 5.5 | CCc1nnc(C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccsc1 | 10.1021/acs.jmedchem.8b01077 | |||
126567264 | 165904 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 533 | 8 | 1 | 6 | 6.3 | Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)s1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4248282 | 165904 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 533 | 8 | 1 | 6 | 6.3 | Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)s1 | 10.1021/acs.jmedchem.8b01077 | |||
3008932 | 205103 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 560 | 6 | 0 | 6 | 6.5 | Cc1nc(-c2ccncc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL61373 | 205103 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 560 | 6 | 0 | 6 | 6.5 | Cc1nc(-c2ccncc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
3008904 | 202422 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 1 | 2 | ChEMBL | 537 | 6 | 0 | 5 | 5.0 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3cccc(C#N)c3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL59511 | 202422 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | 1 | 2 | ChEMBL | 537 | 6 | 0 | 5 | 5.0 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3cccc(C#N)c3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
145983733 | 165567 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 571 | 8 | 1 | 6 | 6.5 | O=C(N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@@H](n1c(C3CC3)nnc1C(F)(F)F)C2)c1ccsc1)C1CCC(F)(F)CC1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4239790 | 165567 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 571 | 8 | 1 | 6 | 6.5 | O=C(N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@@H](n1c(C3CC3)nnc1C(F)(F)F)C2)c1ccsc1)C1CCC(F)(F)CC1 | 10.1021/acs.jmedchem.8b01077 | |||
145982775 | 165644 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 483 | 8 | 1 | 7 | 4.6 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(=O)C1)c1cccs1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4241721 | 165644 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 483 | 8 | 1 | 7 | 4.6 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(=O)C1)c1cccs1 | 10.1021/acs.jmedchem.8b01077 | |||
145985042 | 165762 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 517 | 8 | 1 | 6 | 5.8 | Cc1nnc(C2CC2)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cccs1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4244672 | 165762 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 517 | 8 | 1 | 6 | 5.8 | Cc1nnc(C2CC2)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cccs1 | 10.1021/acs.jmedchem.8b01077 | |||
72711955 | 92705 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 574 | 9 | 1 | 5 | 5.4 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(Cc3ccccn3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435861 | 92705 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 574 | 9 | 1 | 5 | 5.4 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(Cc3ccccn3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
16663418 | 10817 | None | 24 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -1 | 2 | ChEMBL | 590 | 10 | 1 | 7 | 4.7 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172035 | 10817 | None | 24 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -1 | 2 | ChEMBL | 590 | 10 | 1 | 7 | 4.7 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
3008930 | 201136 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 1 | 2 | ChEMBL | 499 | 5 | 0 | 5 | 4.6 | Cc1nc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL58004 | 201136 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 1 | 2 | ChEMBL | 499 | 5 | 0 | 5 | 4.6 | Cc1nc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
16663418 | 10817 | None | 24 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -1 | 2 | ChEMBL | 590 | 10 | 1 | 7 | 4.7 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.046 | |||
CHEMBL1172035 | 10817 | None | 24 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -1 | 2 | ChEMBL | 590 | 10 | 1 | 7 | 4.7 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.046 | |||
44194676 | 10833 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 637 | 11 | 3 | 6 | 3.3 | C=CCN(C(=O)NCc1ccc(S(=O)(=O)NC)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172052 | 10833 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 637 | 11 | 3 | 6 | 3.3 | C=CCN(C(=O)NCc1ccc(S(=O)(=O)NC)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
49864973 | 15792 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 640 | 11 | 2 | 6 | 3.3 | C=CCN(C(=O)Cc1ccc(S(=O)(=O)NC)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2010.05.046 | |||
CHEMBL1222771 | 15792 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 640 | 11 | 2 | 6 | 3.3 | C=CCN(C(=O)Cc1ccc(S(=O)(=O)NC)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2010.05.046 | |||
3500 | 1526 | None | 13 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 245 | 2 | ChEMBL | 483 | 7 | 1 | 5 | 3.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C21CCN(CC2)Cc1ccc2c(c1)OCCO2 | 10.1021/jm060051s | |||
491774 | 1526 | None | 13 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 245 | 2 | ChEMBL | 483 | 7 | 1 | 5 | 3.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C21CCN(CC2)Cc1ccc2c(c1)OCCO2 | 10.1021/jm060051s | |||
CHEMBL1196395 | 1526 | None | 13 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 245 | 2 | ChEMBL | 483 | 7 | 1 | 5 | 3.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C21CCN(CC2)Cc1ccc2c(c1)OCCO2 | 10.1021/jm060051s | |||
49798083 | 10825 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 623 | 9 | 1 | 5 | 5.6 | C=CCN(C(=O)OCc1ccc(Br)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172044 | 10825 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 623 | 9 | 1 | 5 | 5.6 | C=CCN(C(=O)OCc1ccc(Br)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
52948295 | 19070 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 780 | 11 | 2 | 6 | 7.3 | C=CCN(C(=O)Nc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288911 | 19070 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 780 | 11 | 2 | 6 | 7.3 | C=CCN(C(=O)Nc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
145983844 | 165897 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 484 | 8 | 2 | 7 | 3.5 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)[C@@H]1CCC(=O)N1)c1cccs1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4248119 | 165897 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 484 | 8 | 2 | 7 | 3.5 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)[C@@H]1CCC(=O)N1)c1cccs1 | 10.1021/acs.jmedchem.8b01077 | |||
72713859 | 92755 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 532 | 8 | 1 | 5 | 4.9 | Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccccc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435911 | 92755 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 532 | 8 | 1 | 5 | 4.9 | Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccccc2)CC1 | 10.1021/jm401101p | |||
3008919 | 100819 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 453 | 5 | 0 | 3 | 6.0 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2ccccc2)CC1 | 10.1021/jm031046g | |||
CHEMBL292894 | 100819 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 453 | 5 | 0 | 3 | 6.0 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2ccccc2)CC1 | 10.1021/jm031046g | |||
10184169 | 12824 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 441 | 11 | 1 | 3 | 4.4 | CCCN1C(=O)[C@H](CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 | 10.1021/jm060051s | |||
CHEMBL1188324 | 12824 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 441 | 11 | 1 | 3 | 4.4 | CCCN1C(=O)[C@H](CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 | 10.1021/jm060051s | |||
CHEMBL536063 | 12824 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 441 | 11 | 1 | 3 | 4.4 | CCCN1C(=O)[C@H](CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 | 10.1021/jm060051s | |||
56661526 | 66433 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 562 | 8 | 3 | 6 | 3.5 | CCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813447 | 66433 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 562 | 8 | 3 | 6 | 3.5 | CCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851866 | 66433 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 562 | 8 | 3 | 6 | 3.5 | CCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
57331340 | 104634 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 580 | 10 | 0 | 4 | 5.4 | CCN(Cc1ccc(C)cc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
CHEMBL3104677 | 104634 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 580 | 10 | 0 | 4 | 5.4 | CCN(Cc1ccc(C)cc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
118727182 | 117450 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 511 | 8 | 0 | 3 | 6.2 | Cc1ccc(N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)C(=O)c2ccc(F)cc2)cc1Cl | 10.1016/j.bmc.2014.12.052 | |||
CHEMBL3397993 | 117450 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 511 | 8 | 0 | 3 | 6.2 | Cc1ccc(N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)C(=O)c2ccc(F)cc2)cc1Cl | 10.1016/j.bmc.2014.12.052 | |||
46191232 | 202130 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 618 | 6 | 0 | 4 | 5.7 | Cc1cc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL593046 | 202130 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 618 | 6 | 0 | 4 | 5.7 | Cc1cc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
21927139 | 14384 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 518 | 9 | 1 | 5 | 5.3 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)nc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1200232 | 14384 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 518 | 9 | 1 | 5 | 5.3 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)nc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL3216934 | 14384 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 518 | 9 | 1 | 5 | 5.3 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)nc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
168293785 | 192285 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 576 | 9 | 1 | 8 | 4.2 | Cc1csc([C@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCN(S(C)(=O)=O)CC2)c1 | 10.1021/acs.jmedchem.2c01383 | |||
CHEMBL5204027 | 192285 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 576 | 9 | 1 | 8 | 4.2 | Cc1csc([C@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCN(S(C)(=O)=O)CC2)c1 | 10.1021/acs.jmedchem.2c01383 | |||
52944618 | 19080 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 797 | 13 | 2 | 6 | 6.1 | C=CCN(C(=O)Cc1ccc(C(N)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288921 | 19080 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 797 | 13 | 2 | 6 | 6.1 | C=CCN(C(=O)Cc1ccc(C(N)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
10186729 | 13958 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 493 | 9 | 2 | 5 | 4.0 | CCCCN1C(=O)[C@@H]([C@@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
CHEMBL1196666 | 13958 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 493 | 9 | 2 | 5 | 4.0 | CCCCN1C(=O)[C@@H]([C@@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
CHEMBL557789 | 13958 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 493 | 9 | 2 | 5 | 4.0 | CCCCN1C(=O)[C@@H]([C@@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
56678576 | 66649 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 576 | 9 | 3 | 6 | 3.9 | CCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813449 | 66649 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 576 | 9 | 3 | 6 | 3.9 | CCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1852754 | 66649 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | - | 1 | ChEMBL | 576 | 9 | 3 | 6 | 3.9 | CCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
118727181 | 117449 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 431 | 7 | 0 | 3 | 4.7 | CC(=O)N(CCCN1CCN(Cc2ccc(F)cc2)CC1C)c1ccc(C)c(Cl)c1 | 10.1016/j.bmc.2014.12.052 | |||
CHEMBL3397992 | 117449 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 431 | 7 | 0 | 3 | 4.7 | CC(=O)N(CCCN1CCN(Cc2ccc(F)cc2)CC1C)c1ccc(C)c(Cl)c1 | 10.1016/j.bmc.2014.12.052 | |||
3008911 | 101035 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 458 | 4 | 1 | 4 | 5.4 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3cccc4ccn(C)c34)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL294271 | 101035 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 458 | 4 | 1 | 4 | 5.4 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3cccc4ccn(C)c34)CC2)CC1 | 10.1021/jm031046g | |||
52947063 | 19061 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 788 | 12 | 1 | 6 | 7.7 | C=CCN(C(=O)OCc1ccc(F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288874 | 19061 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 788 | 12 | 1 | 6 | 7.7 | C=CCN(C(=O)OCc1ccc(F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
46225533 | 202133 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 590 | 6 | 0 | 4 | 4.9 | Cc1cc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL593080 | 202133 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 590 | 6 | 0 | 4 | 4.9 | Cc1cc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
73355478 | 92721 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 509 | 7 | 0 | 3 | 7.3 | O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(Oc3ccccc3)cc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435877 | 92721 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 509 | 7 | 0 | 3 | 7.3 | O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(Oc3ccccc3)cc2)CC1 | 10.1021/jm401101p | |||
49798081 | 10823 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 563 | 9 | 1 | 5 | 5.0 | C=CCN(C(=O)OCc1ccc(F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172042 | 10823 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 563 | 9 | 1 | 5 | 5.0 | C=CCN(C(=O)OCc1ccc(F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
16659334 | 14009 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 493 | 9 | 2 | 5 | 4.0 | CCCCN1C(=O)[C@@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL1197042 | 14009 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 493 | 9 | 2 | 5 | 4.0 | CCCCN1C(=O)[C@@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL559168 | 14009 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 493 | 9 | 2 | 5 | 4.0 | CCCCN1C(=O)[C@@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
3008931 | 205104 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 559 | 6 | 0 | 5 | 7.1 | Cc1nc(-c2ccccc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL61374 | 205104 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 559 | 6 | 0 | 5 | 7.1 | Cc1nc(-c2ccccc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
90656333 | 111132 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 509 | 7 | 1 | 6 | 4.6 | CC(C)Oc1ccc(N2CCN(Cc3ccc(Br)cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.bmcl.2014.03.073 | |||
CHEMBL3263029 | 111132 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 509 | 7 | 1 | 6 | 4.6 | CC(C)Oc1ccc(N2CCN(Cc3ccc(Br)cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.bmcl.2014.03.073 | |||
56678574 | 66400 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 593 | 10 | 4 | 7 | 3.6 | CCCCN1C(=O)[C@@H]([C@@H](O)C2CCC(O)CC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813443 | 66400 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 593 | 10 | 4 | 7 | 3.6 | CCCCN1C(=O)[C@@H]([C@@H](O)C2CCC(O)CC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851694 | 66400 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 593 | 10 | 4 | 7 | 3.6 | CCCCN1C(=O)[C@@H]([C@@H](O)C2CCC(O)CC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
56664937 | 66432 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 549 | 8 | 3 | 6 | 3.8 | CCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813446 | 66432 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 549 | 8 | 3 | 6 | 3.8 | CCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851865 | 66432 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 549 | 8 | 3 | 6 | 3.8 | CCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
118727190 | 117458 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 521 | 7 | 0 | 5 | 4.3 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(c3ccc(C#N)cc3)CC2)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
CHEMBL3398001 | 117458 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 521 | 7 | 0 | 5 | 4.3 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(c3ccc(C#N)cc3)CC2)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
122185637 | 122986 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 470 | 8 | 2 | 2 | 4.5 | CCc1ccc(C(=O)NCc2c(C)c(CNC(=O)c3ccc(CC)cc3)c3[n+](c2C)CCC3)cc1 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3604310 | 122986 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 470 | 8 | 2 | 2 | 4.5 | CCc1ccc(C(=O)NCc2c(C)c(CNC(=O)c3ccc(CC)cc3)c3[n+](c2C)CCC3)cc1 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3606111 | 122986 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 470 | 8 | 2 | 2 | 4.5 | CCc1ccc(C(=O)NCc2c(C)c(CNC(=O)c3ccc(CC)cc3)c3[n+](c2C)CCC3)cc1 | 10.1016/j.bmcl.2015.06.029 | |||
52948264 | 19059 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 815 | 13 | 1 | 8 | 7.5 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288872 | 19059 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 815 | 13 | 1 | 8 | 7.5 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
46225532 | 202129 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 547 | 6 | 0 | 5 | 3.8 | Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL593042 | 202129 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 547 | 6 | 0 | 5 | 3.8 | Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
44404643 | 72246 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 611 | 12 | 1 | 6 | 4.5 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC(c2ccccc2)c2ccc(NS(C)(=O)=O)cc2)CC1 | 10.1016/j.bmcl.2005.08.014 | |||
CHEMBL198114 | 72246 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 611 | 12 | 1 | 6 | 4.5 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC(c2ccccc2)c2ccc(NS(C)(=O)=O)cc2)CC1 | 10.1016/j.bmcl.2005.08.014 | |||
3008930 | 201136 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 499 | 5 | 0 | 5 | 4.6 | Cc1nc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL58004 | 201136 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 1 | 2 | ChEMBL | 499 | 5 | 0 | 5 | 4.6 | Cc1nc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
145983159 | 166024 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 497 | 8 | 1 | 7 | 4.8 | Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2=CCOCC2)s1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4250560 | 166024 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 497 | 8 | 1 | 7 | 4.8 | Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2=CCOCC2)s1 | 10.1021/acs.jmedchem.8b01077 | |||
3008932 | 205103 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 560 | 6 | 0 | 6 | 6.5 | Cc1nc(-c2ccncc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL61373 | 205103 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 560 | 6 | 0 | 6 | 6.5 | Cc1nc(-c2ccncc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
72711506 | 92746 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 511 | 8 | 1 | 4 | 4.8 | CCN1C[C@@H](c2ccccc2)N(C2CCN(C(C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)C1=O | 10.1021/jm401101p | |||
CHEMBL2435902 | 92746 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 511 | 8 | 1 | 4 | 4.8 | CCN1C[C@@H](c2ccccc2)N(C2CCN(C(C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)C1=O | 10.1021/jm401101p | |||
162674876 | 183441 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | -109 | 2 | ChEMBL | 1169 | 26 | 7 | 15 | 5.8 | Cc1nnc(C(C)C)n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(=O)NCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)cc1 | 10.1016/j.bmc.2016.09.059 | |||
CHEMBL4797451 | 183441 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | -109 | 2 | ChEMBL | 1169 | 26 | 7 | 15 | 5.8 | Cc1nnc(C(C)C)n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(=O)NCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)cc1 | 10.1016/j.bmc.2016.09.059 | |||
46225428 | 202397 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 503 | 5 | 0 | 5 | 3.7 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C(C)(C)C)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL594914 | 202397 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 503 | 5 | 0 | 5 | 3.7 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C(C)(C)C)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
52948295 | 19070 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 780 | 11 | 2 | 6 | 7.3 | C=CCN(C(=O)Nc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288911 | 19070 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 780 | 11 | 2 | 6 | 7.3 | C=CCN(C(=O)Nc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
118727173 | 117441 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 538 | 8 | 0 | 4 | 5.1 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(C)cc3)CC2C)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
CHEMBL3397984 | 117441 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 538 | 8 | 0 | 4 | 5.1 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(C)cc3)CC2C)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
118727178 | 117446 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 528 | 8 | 0 | 4 | 4.7 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)c2cccc(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
CHEMBL3397989 | 117446 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 528 | 8 | 0 | 4 | 4.7 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)c2cccc(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
3002977 | 2460 | None | 43 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.ejmech.2013.11.013 | |||
3002977.0 | 2460 | None | 43 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.ejmech.2013.11.013 | |||
803 | 2460 | None | 43 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.ejmech.2013.11.013 | |||
806 | 2460 | None | 43 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.ejmech.2013.11.013 | |||
CHEMBL1201187 | 2460 | None | 43 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.ejmech.2013.11.013 | |||
CHEMBL256907 | 2460 | None | 43 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.ejmech.2013.11.013 | |||
CHEMBL584744 | 2460 | None | 43 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.ejmech.2013.11.013 | |||
DB04835 | 2460 | None | 43 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.ejmech.2013.11.013 | |||
57331278 | 104641 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 572 | 9 | 1 | 4 | 5.0 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCc3ccc(Cl)cc3)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
CHEMBL3104684 | 104641 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 572 | 9 | 1 | 4 | 5.0 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCc3ccc(Cl)cc3)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
3008908 | 205125 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 439 | 4 | 1 | 3 | 5.5 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(Cl)cc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL61466 | 205125 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 439 | 4 | 1 | 3 | 5.5 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(Cl)cc3)CC2)CC1 | 10.1021/jm031046g | |||
57331274 | 104639 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 538 | 9 | 1 | 4 | 4.4 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCc3ccccc3)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
CHEMBL3104682 | 104639 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 538 | 9 | 1 | 4 | 4.4 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCc3ccccc3)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
56661524 | 66452 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 549 | 10 | 3 | 6 | 3.8 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813438 | 66452 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 549 | 10 | 3 | 6 | 3.8 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851951 | 66452 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 549 | 10 | 3 | 6 | 3.8 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
16124598 | 10733 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 472 | 6 | 2 | 5 | 5.3 | O=C(O)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171008 | 10733 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 472 | 6 | 2 | 5 | 5.3 | O=C(O)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
145986205 | 165756 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 532 | 8 | 1 | 6 | 5.5 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(F)nc1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4244470 | 165756 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 532 | 8 | 1 | 6 | 5.5 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(F)nc1 | 10.1021/acs.jmedchem.8b01077 | |||
76313867 | 104649 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 566 | 10 | 0 | 4 | 4.9 | CCN(C(=O)Cc1ccccc1)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
CHEMBL3104694 | 104649 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 566 | 10 | 0 | 4 | 4.9 | CCN(C(=O)Cc1ccccc1)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
46837553 | 103462 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 569 | 10 | 1 | 6 | 6.2 | Cc1nnc(C(C)C)n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)COc1ccccc1)c1ccc(C(F)(F)F)cc1 | 10.1016/j.ejmech.2010.03.003 | |||
CHEMBL3084747 | 103462 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 569 | 10 | 1 | 6 | 6.2 | Cc1nnc(C(C)C)n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)COc1ccccc1)c1ccc(C(F)(F)F)cc1 | 10.1016/j.ejmech.2010.03.003 | |||
90656342 | 111193 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 488 | 8 | 2 | 7 | 3.8 | CC(=O)Nc1ccc(CN2CCN(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 | 10.1016/j.bmcl.2014.03.073 | |||
CHEMBL3263321 | 111193 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 488 | 8 | 2 | 7 | 3.8 | CC(=O)Nc1ccc(CN2CCN(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 | 10.1016/j.bmcl.2014.03.073 | |||
118727183 | 117451 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 542 | 8 | 0 | 4 | 5.0 | CC(=O)N1CCCC(C(=O)N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)c2ccc(C)c(Cl)c2)C1 | 10.1016/j.bmc.2014.12.052 | |||
CHEMBL3397994 | 117451 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 542 | 8 | 0 | 4 | 5.0 | CC(=O)N1CCCC(C(=O)N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)c2ccc(C)c(Cl)c2)C1 | 10.1016/j.bmc.2014.12.052 | |||
11433338 | 69222 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 594 | 10 | 1 | 5 | 7.0 | CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2ccccc2)c2ccc(OC(F)(F)F)cc2)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926874 | 69222 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 594 | 10 | 1 | 5 | 7.0 | CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2ccccc2)c2ccc(OC(F)(F)F)cc2)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
52944616 | 19073 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 827 | 13 | 2 | 7 | 6.9 | C=CCN(C(=O)NCc1ccc(C(=O)OC)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288914 | 19073 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 827 | 13 | 2 | 7 | 6.9 | C=CCN(C(=O)NCc1ccc(C(=O)OC)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
3008934 | 201149 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 467 | 5 | 0 | 3 | 6.2 | Cc1cccc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL58101 | 201149 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 467 | 5 | 0 | 3 | 6.2 | Cc1cccc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
11693007 | 76288 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 548 | 8 | 1 | 4 | 5.7 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(Nc3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
CHEMBL205851 | 76288 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 548 | 8 | 1 | 4 | 5.7 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(Nc3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
57331307 | 104646 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 580 | 11 | 0 | 4 | 5.1 | CCN(CCc1ccccc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
CHEMBL3104691 | 104646 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 580 | 11 | 0 | 4 | 5.1 | CCN(CCc1ccccc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
23577386 | 66393 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 626 | 11 | 3 | 7 | 4.3 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(NS(C)(=O)=O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813435 | 66393 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 626 | 11 | 3 | 7 | 4.3 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(NS(C)(=O)=O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851672 | 66393 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 626 | 11 | 3 | 7 | 4.3 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(NS(C)(=O)=O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
122185617 | 122978 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 498 | 8 | 2 | 2 | 5.6 | Cc1c(CNC(=O)c2ccc(C(C)C)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(C(C)C)cc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3604300 | 122978 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 498 | 8 | 2 | 2 | 5.6 | Cc1c(CNC(=O)c2ccc(C(C)C)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(C(C)C)cc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3606050 | 122978 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 498 | 8 | 2 | 2 | 5.6 | Cc1c(CNC(=O)c2ccc(C(C)C)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(C(C)C)cc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
52949523 | 19065 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 854 | 13 | 1 | 7 | 8.4 | C=CCN(C(=O)OCc1ccc(OC(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288878 | 19065 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 854 | 13 | 1 | 7 | 8.4 | C=CCN(C(=O)OCc1ccc(OC(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
46225514 | 202281 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 537 | 7 | 0 | 6 | 3.0 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(S(=O)(=O)C4CCCC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL594208 | 202281 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 537 | 7 | 0 | 6 | 3.0 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(S(=O)(=O)C4CCCC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
46225512 | 204057 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 489 | 5 | 0 | 5 | 3.3 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C(C)(C)C)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL605727 | 204057 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 489 | 5 | 0 | 5 | 3.3 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C(C)(C)C)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
126567281 | 165605 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 520 | 8 | 1 | 7 | 5.4 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cscn1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4240742 | 165605 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 520 | 8 | 1 | 7 | 5.4 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cscn1 | 10.1021/acs.jmedchem.8b01077 | |||
49864977 | 15798 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 681 | 11 | 3 | 6 | 4.0 | C=CCN(C(=O)NCc1ccc(S(=O)(=O)NC)cc1)[C@H]1C[C@@H]2CC[C@H](C1)N2C[C@H]1CN(C(=O)C2CCCC2)C[C@]1(O)c1cccc(F)c1 | 10.1016/j.bmcl.2010.05.046 | |||
CHEMBL1222777 | 15798 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 681 | 11 | 3 | 6 | 4.0 | C=CCN(C(=O)NCc1ccc(S(=O)(=O)NC)cc1)[C@H]1C[C@@H]2CC[C@H](C1)N2C[C@H]1CN(C(=O)C2CCCC2)C[C@]1(O)c1cccc(F)c1 | 10.1016/j.bmcl.2010.05.046 | |||
3008909 | 201556 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 473 | 4 | 1 | 3 | 5.9 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(C(F)(F)F)cc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL58897 | 201556 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 473 | 4 | 1 | 3 | 5.9 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(C(F)(F)F)cc3)CC2)CC1 | 10.1021/jm031046g | |||
491773 | 12832 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | 67 | 2 | ChEMBL | 455 | 12 | 1 | 3 | 4.8 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 | 10.1021/jm060051s | |||
CHEMBL1188399 | 12832 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | 67 | 2 | ChEMBL | 455 | 12 | 1 | 3 | 4.8 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 | 10.1021/jm060051s | |||
CHEMBL536288 | 12832 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | 67 | 2 | ChEMBL | 455 | 12 | 1 | 3 | 4.8 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 | 10.1021/jm060051s | |||
11634966 | 12883 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 481 | 11 | 1 | 3 | 5.3 | CCCN1C(=O)[C@@H](CC2CCCCC2)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 | 10.1021/jm060051s | |||
CHEMBL1188808 | 12883 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 481 | 11 | 1 | 3 | 5.3 | CCCN1C(=O)[C@@H](CC2CCCCC2)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 | 10.1021/jm060051s | |||
CHEMBL537425 | 12883 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 481 | 11 | 1 | 3 | 5.3 | CCCN1C(=O)[C@@H](CC2CCCCC2)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 | 10.1021/jm060051s | |||
491773 | 12832 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | 67 | 2 | ChEMBL | 455 | 12 | 1 | 3 | 4.8 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1188399 | 12832 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | 67 | 2 | ChEMBL | 455 | 12 | 1 | 3 | 4.8 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL536288 | 12832 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | 67 | 2 | ChEMBL | 455 | 12 | 1 | 3 | 4.8 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
90656339 | 111190 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 446 | 7 | 2 | 7 | 3.4 | CC(C)Oc1ccc(N2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.bmcl.2014.03.073 | |||
CHEMBL3263318 | 111190 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 446 | 7 | 2 | 7 | 3.4 | CC(C)Oc1ccc(N2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.bmcl.2014.03.073 | |||
46225515 | 202111 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 551 | 6 | 0 | 5 | 4.1 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL592940 | 202111 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 551 | 6 | 0 | 5 | 4.1 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
46225350 | 203615 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 515 | 7 | 0 | 5 | 3.8 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)CC4CCCC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL603325 | 203615 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 515 | 7 | 0 | 5 | 3.8 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)CC4CCCC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
10280945 | 12844 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 517 | 9 | 1 | 4 | 5.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
CHEMBL1188557 | 12844 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 517 | 9 | 1 | 4 | 5.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
CHEMBL536743 | 12844 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 517 | 9 | 1 | 4 | 5.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
10280945 | 12844 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 517 | 9 | 1 | 4 | 5.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL1188557 | 12844 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 517 | 9 | 1 | 4 | 5.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL536743 | 12844 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 517 | 9 | 1 | 4 | 5.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
10280945 | 12844 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 517 | 9 | 1 | 4 | 5.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1188557 | 12844 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 517 | 9 | 1 | 4 | 5.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL536743 | 12844 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 517 | 9 | 1 | 4 | 5.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
21064281 | 14336 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 596 | 10 | 2 | 6 | 4.6 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(S(N)(=O)=O)cc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1170877 | 14336 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 596 | 10 | 2 | 6 | 4.6 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(S(N)(=O)=O)cc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1200018 | 14336 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 596 | 10 | 2 | 6 | 4.6 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(S(N)(=O)=O)cc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
10280945 | 12844 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 517 | 9 | 1 | 4 | 5.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL1188557 | 12844 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 517 | 9 | 1 | 4 | 5.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL536743 | 12844 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 517 | 9 | 1 | 4 | 5.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
457871 | 100777 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 483 | 4 | 1 | 3 | 5.6 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(Br)cc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL292625 | 100777 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 483 | 4 | 1 | 3 | 5.6 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(Br)cc3)CC2)CC1 | 10.1021/jm031046g | |||
3008918 | 201840 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 467 | 5 | 0 | 3 | 6.3 | Cc1ccccc1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL59101 | 201840 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 467 | 5 | 0 | 3 | 6.3 | Cc1ccccc1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
23577370 | 66385 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 549 | 9 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813270 | 66385 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 549 | 9 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851623 | 66385 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | - | 1 | ChEMBL | 549 | 9 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
73351059 | 92848 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 459 | 8 | 1 | 5 | 5.6 | CCOc1ccc(C2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1ccccc1 | 10.1016/j.ejmech.2013.09.004 | |||
CHEMBL2436819 | 92848 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 459 | 8 | 1 | 5 | 5.6 | CCOc1ccc(C2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1ccccc1 | 10.1016/j.ejmech.2013.09.004 | |||
56678576 | 66649 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 576 | 9 | 3 | 6 | 3.9 | CCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813449 | 66649 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 576 | 9 | 3 | 6 | 3.9 | CCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1852754 | 66649 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 576 | 9 | 3 | 6 | 3.9 | CCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
90656343 | 111194 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 474 | 8 | 1 | 7 | 3.9 | CC(C)Oc1ccc(N2CCN(Cc3ccc(N(C)C)cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.bmcl.2014.03.073 | |||
CHEMBL3263322 | 111194 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | ChEMBL | 474 | 8 | 1 | 7 | 3.9 | CC(C)Oc1ccc(N2CCN(Cc3ccc(N(C)C)cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.bmcl.2014.03.073 | |||
3008926 | 204303 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 492 | 5 | 1 | 3 | 6.5 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2c[nH]c3ccccc23)CC1 | 10.1021/jm031046g | |||
CHEMBL60711 | 204303 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 492 | 5 | 1 | 3 | 6.5 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2c[nH]c3ccccc23)CC1 | 10.1021/jm031046g | |||
73355550 | 92828 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 445 | 7 | 1 | 5 | 5.2 | COc1ccc(C2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1ccccc1 | 10.1016/j.ejmech.2013.09.004 | |||
CHEMBL2436720 | 92828 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 445 | 7 | 1 | 5 | 5.2 | COc1ccc(C2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1ccccc1 | 10.1016/j.ejmech.2013.09.004 | |||
50993435 | 57215 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 511 | 8 | 1 | 5 | 5.2 | CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(Cc1ccccc1)CC3)C2)c1ccccc1 | 10.1021/jm100978n | |||
CHEMBL1649914 | 57215 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 511 | 8 | 1 | 5 | 5.2 | CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(Cc1ccccc1)CC3)C2)c1ccccc1 | 10.1021/jm100978n | |||
10272003 | 58896 | None | 1 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -4 | 3 | ChEMBL | 395 | 2 | 2 | 5 | 3.4 | Cc1nn(C)c2ncc(C(=O)NC(=O)Nc3ccc(F)c(C(F)(F)F)c3)cc12 | 10.1021/jm1012903 | |||
CHEMBL1688888 | 58896 | None | 1 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -4 | 3 | ChEMBL | 395 | 2 | 2 | 5 | 3.4 | Cc1nn(C)c2ncc(C(=O)NC(=O)Nc3ccc(F)c(C(F)(F)F)c3)cc12 | 10.1021/jm1012903 | |||
145983098 | 165832 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 513 | 7 | 1 | 7 | 4.3 | Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)N2CCN(C)CC2)s1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4246290 | 165832 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 513 | 7 | 1 | 7 | 4.3 | Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)N2CCN(C)CC2)s1 | 10.1021/acs.jmedchem.8b01077 | |||
118727189 | 117457 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 542 | 8 | 0 | 4 | 5.0 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(F)cc3)C[C@@H]2C)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
CHEMBL3398000 | 117457 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 542 | 8 | 0 | 4 | 5.0 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(F)cc3)C[C@@H]2C)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
57402799 | 69230 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 603 | 9 | 1 | 5 | 7.0 | CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2cccc(C#N)c2)c2ccc(C(F)(F)F)cc2)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926884 | 69230 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 603 | 9 | 1 | 5 | 7.0 | CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2cccc(C#N)c2)c2ccc(C(F)(F)F)cc2)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
57397597 | 69232 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 619 | 10 | 1 | 6 | 6.8 | CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2cccc(C#N)c2)c2ccc(OC(F)(F)F)cc2)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926886 | 69232 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 619 | 10 | 1 | 6 | 6.8 | CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2cccc(C#N)c2)c2ccc(OC(F)(F)F)cc2)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
10106 | 873 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 519 | 8 | 1 | 6 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccsc1)CCN1[C@@H]2CC[C@H]1C[C@@H](C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.8b01077 | |||
91820689 | 873 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 519 | 8 | 1 | 6 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccsc1)CCN1[C@@H]2CC[C@H]1C[C@@H](C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4249798 | 873 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 519 | 8 | 1 | 6 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccsc1)CCN1[C@@H]2CC[C@H]1C[C@@H](C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.8b01077 | |||
145985672 | 165487 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 501 | 8 | 1 | 6 | 5.7 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)CC1)c1cccs1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4237964 | 165487 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 501 | 8 | 1 | 6 | 5.7 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)CC1)c1cccs1 | 10.1021/acs.jmedchem.8b01077 | |||
49871007 | 58830 | None | 15 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 559 | 5 | 0 | 6 | 4.8 | CCO[C@@H]1Cc2cc(C(F)(F)F)ccc2[C@H]1N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C | 10.1021/ml1001536 | |||
CHEMBL1688243 | 58830 | None | 15 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 559 | 5 | 0 | 6 | 4.8 | CCO[C@@H]1Cc2cc(C(F)(F)F)ccc2[C@H]1N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C | 10.1021/ml1001536 | |||
49871007 | 58830 | None | 15 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 559 | 5 | 0 | 6 | 4.8 | CCO[C@@H]1Cc2cc(C(F)(F)F)ccc2[C@H]1N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C | 10.1021/ml1001536 | |||
CHEMBL1688243 | 58830 | None | 15 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 559 | 5 | 0 | 6 | 4.8 | CCO[C@@H]1Cc2cc(C(F)(F)F)ccc2[C@H]1N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C | 10.1021/ml1001536 | |||
50992575 | 57218 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 463 | 7 | 1 | 5 | 4.4 | CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(C)C)CC3)C2)c1ccccc1 | 10.1021/jm100978n | |||
CHEMBL1649917 | 57218 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 463 | 7 | 1 | 5 | 4.4 | CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(C)C)CC3)C2)c1ccccc1 | 10.1021/jm100978n | |||
46225533 | 202133 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 590 | 6 | 0 | 4 | 4.9 | Cc1cc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL593080 | 202133 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 590 | 6 | 0 | 4 | 4.9 | Cc1cc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
3008935 | 205186 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 468 | 5 | 0 | 4 | 5.6 | Cc1ccnc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL61828 | 205186 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 468 | 5 | 0 | 4 | 5.6 | Cc1ccnc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
3008913 | 102031 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -1 | 2 | ChEMBL | 495 | 6 | 0 | 3 | 6.5 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL301454 | 102031 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -1 | 2 | ChEMBL | 495 | 6 | 0 | 3 | 6.5 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
3013684 | 77066 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 547 | 8 | 0 | 3 | 6.1 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
CHEMBL207182 | 77066 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 547 | 8 | 0 | 3 | 6.1 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
122668190 | 165493 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 469 | 8 | 1 | 6 | 5.4 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCCC1)c1cccs1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4238063 | 165493 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 469 | 8 | 1 | 6 | 5.4 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCCC1)c1cccs1 | 10.1021/acs.jmedchem.8b01077 | |||
49798087 | 10828 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 589 | 10 | 2 | 6 | 4.3 | C=CCN(C(=O)NCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172047 | 10828 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 589 | 10 | 2 | 6 | 4.3 | C=CCN(C(=O)NCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
52941648 | 19076 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 822 | 12 | 1 | 5 | 8.0 | C=CCN(C(=O)Cc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288917 | 19076 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 822 | 12 | 1 | 5 | 8.0 | C=CCN(C(=O)Cc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
3008929 | 198093 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -1 | 2 | ChEMBL | 498 | 5 | 0 | 4 | 5.2 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL556314 | 198093 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -1 | 2 | ChEMBL | 498 | 5 | 0 | 4 | 5.2 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
44194587 | 10892 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 636 | 11 | 1 | 6 | 3.5 | C=CCN(C(=O)Cc1ccc(S(=O)(=O)N(C)C)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172626 | 10892 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 636 | 11 | 1 | 6 | 3.5 | C=CCN(C(=O)Cc1ccc(S(=O)(=O)N(C)C)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
73347894 | 92707 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 574 | 9 | 1 | 5 | 5.4 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(Cc3cccnc3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435863 | 92707 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 574 | 9 | 1 | 5 | 5.4 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(Cc3cccnc3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
3008929 | 198093 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -1 | 2 | ChEMBL | 498 | 5 | 0 | 4 | 5.2 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL556314 | 198093 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -1 | 2 | ChEMBL | 498 | 5 | 0 | 4 | 5.2 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
49798129 | 10842 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 529 | 9 | 1 | 4 | 4.2 | C=CCN(C(=O)Cc1ccccc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172157 | 10842 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 529 | 9 | 1 | 4 | 4.2 | C=CCN(C(=O)Cc1ccccc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
16663418 | 10817 | None | 24 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -1 | 2 | ChEMBL | 590 | 10 | 1 | 7 | 4.7 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172035 | 10817 | None | 24 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -1 | 2 | ChEMBL | 590 | 10 | 1 | 7 | 4.7 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
53319838 | 58829 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 545 | 4 | 0 | 6 | 4.4 | CO[C@@H]1Cc2cc(C(F)(F)F)ccc2[C@H]1N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C | 10.1021/ml1001536 | |||
CHEMBL1688242 | 58829 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 545 | 4 | 0 | 6 | 4.4 | CO[C@@H]1Cc2cc(C(F)(F)F)ccc2[C@H]1N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C | 10.1021/ml1001536 | |||
3008923 | 201355 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 521 | 5 | 0 | 3 | 7.3 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2c(Cl)cccc2Cl)CC1 | 10.1021/jm031046g | |||
CHEMBL58441 | 201355 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 521 | 5 | 0 | 3 | 7.3 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2c(Cl)cccc2Cl)CC1 | 10.1021/jm031046g | |||
59458245 | 92710 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 617 | 10 | 2 | 5 | 5.7 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(Cc3ccc(C(=O)O)cc3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435866 | 92710 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 617 | 10 | 2 | 5 | 5.7 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(Cc3ccc(C(=O)O)cc3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
72711508 | 92749 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 539 | 7 | 1 | 4 | 5.6 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C(C)(C)C)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435905 | 92749 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 539 | 7 | 1 | 4 | 5.6 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C(C)(C)C)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
49798133 | 10736 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 563 | 9 | 1 | 4 | 4.9 | C=CCN(C(=O)Cc1ccc(Cl)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1171030 | 10736 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 563 | 9 | 1 | 4 | 4.9 | C=CCN(C(=O)Cc1ccc(Cl)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
52947091 | 19071 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 794 | 12 | 2 | 6 | 7.0 | C=CCN(C(=O)NCc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288912 | 19071 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 794 | 12 | 2 | 6 | 7.0 | C=CCN(C(=O)NCc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
3008924 | 202159 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 503 | 5 | 0 | 3 | 7.1 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2cccc3ccccc23)CC1 | 10.1021/jm031046g | |||
CHEMBL59328 | 202159 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 503 | 5 | 0 | 3 | 7.1 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2cccc3ccccc23)CC1 | 10.1021/jm031046g | |||
3008905 | 201174 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 537 | 6 | 0 | 5 | 5.0 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccc(C#N)cc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL58248 | 201174 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 537 | 6 | 0 | 5 | 5.0 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccc(C#N)cc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
52947091 | 19071 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 794 | 12 | 2 | 6 | 7.0 | C=CCN(C(=O)NCc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288912 | 19071 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 794 | 12 | 2 | 6 | 7.0 | C=CCN(C(=O)NCc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
11585418 | 76038 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 597 | 8 | 0 | 5 | 5.1 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(S(=O)(=O)c3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
CHEMBL205539 | 76038 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 597 | 8 | 0 | 5 | 5.1 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(S(=O)(=O)c3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
49864977 | 15796 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 681 | 11 | 3 | 6 | 4.0 | C=CCN(C(=O)NCc1ccc(S(=O)(=O)NC)cc1)[C@@H]1C[C@@H]2CC[C@H](C1)N2C[C@H]1CN(C(=O)C2CCCC2)C[C@]1(O)c1cccc(F)c1 | 10.1016/j.bmcl.2010.05.046 | |||
CHEMBL1222775 | 15796 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 681 | 11 | 3 | 6 | 4.0 | C=CCN(C(=O)NCc1ccc(S(=O)(=O)NC)cc1)[C@@H]1C[C@@H]2CC[C@H](C1)N2C[C@H]1CN(C(=O)C2CCCC2)C[C@]1(O)c1cccc(F)c1 | 10.1016/j.bmcl.2010.05.046 | |||
118727179 | 117447 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 556 | 7 | 0 | 4 | 4.6 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(C(=O)c3ccc(F)cc3)CC2C)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
CHEMBL3397990 | 117447 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 556 | 7 | 0 | 4 | 4.6 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(C(=O)c3ccc(F)cc3)CC2C)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
11399408 | 69227 | None | 1 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 622 | 9 | 1 | 4 | 7.5 | CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2cccc(Cl)c2)c2ccc(Br)cc2)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926880 | 69227 | None | 1 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 622 | 9 | 1 | 4 | 7.5 | CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2cccc(Cl)c2)c2ccc(Br)cc2)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
46225528 | 202122 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 619 | 6 | 0 | 5 | 5.1 | Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL592993 | 202122 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 619 | 6 | 0 | 5 | 5.1 | Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
46225526 | 202189 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 523 | 6 | 0 | 5 | 3.3 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL593520 | 202189 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 523 | 6 | 0 | 5 | 3.3 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
49864968 | 15787 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 608 | 10 | 1 | 7 | 4.9 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2010.05.046 | |||
CHEMBL1222766 | 15787 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 608 | 10 | 1 | 7 | 4.9 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2010.05.046 | |||
49864976 | 15795 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 606 | 9 | 2 | 4 | 5.2 | C=CCN(C(=O)NCc1ccc(F)cc1)[C@@H]1C[C@@H]2CC[C@H](C1)N2C[C@H]1CN(C(=O)C2CCCC2)C[C@]1(O)c1cccc(F)c1 | 10.1016/j.bmcl.2010.05.046 | |||
CHEMBL1222774 | 15795 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 606 | 9 | 2 | 4 | 5.2 | C=CCN(C(=O)NCc1ccc(F)cc1)[C@@H]1C[C@@H]2CC[C@H](C1)N2C[C@H]1CN(C(=O)C2CCCC2)C[C@]1(O)c1cccc(F)c1 | 10.1016/j.bmcl.2010.05.046 | |||
3008932 | 205103 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 560 | 6 | 0 | 6 | 6.5 | Cc1nc(-c2ccncc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL61373 | 205103 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 560 | 6 | 0 | 6 | 6.5 | Cc1nc(-c2ccncc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
118727175 | 117443 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 542 | 8 | 0 | 4 | 5.0 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccccc3F)CC2C)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
CHEMBL3397986 | 117443 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 542 | 8 | 0 | 4 | 5.0 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccccc3F)CC2C)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
11598797 | 12931 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 481 | 11 | 1 | 3 | 5.3 | CCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 | 10.1021/jm060051s | |||
CHEMBL1189134 | 12931 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 481 | 11 | 1 | 3 | 5.3 | CCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 | 10.1021/jm060051s | |||
CHEMBL538084 | 12931 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 481 | 11 | 1 | 3 | 5.3 | CCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 | 10.1021/jm060051s | |||
10143882 | 14350 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 511 | 8 | 1 | 4 | 5.4 | CC(C)CC1NC(=O)C2(CCN(Cc3ccc(Oc4ccccc4)cc3)CC2)N(Cc2ccccc2)C1=O | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1171289 | 14350 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 511 | 8 | 1 | 4 | 5.4 | CC(C)CC1NC(=O)C2(CCN(Cc3ccc(Oc4ccccc4)cc3)CC2)N(Cc2ccccc2)C1=O | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1200078 | 14350 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 511 | 8 | 1 | 4 | 5.4 | CC(C)CC1NC(=O)C2(CCN(Cc3ccc(Oc4ccccc4)cc3)CC2)N(Cc2ccccc2)C1=O | 10.1016/j.bmc.2010.05.057 | |||
505866 | 28432 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 475 | 7 | 0 | 4 | 4.7 | CCCN(c1ccccn1)C1CCN(C[C@H]2CN(C(=O)N3CCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL137524 | 28432 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 475 | 7 | 0 | 4 | 4.7 | CCCN(c1ccccn1)C1CCN(C[C@H]2CN(C(=O)N3CCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
505865 | 29287 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 516 | 8 | 0 | 4 | 6.0 | CCCN(c1ccccn1)C1CCN(C[C@H]2CN(C(=O)c3ccccc3Cl)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL138282 | 29287 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 516 | 8 | 0 | 4 | 6.0 | CCCN(c1ccccn1)C1CCN(C[C@H]2CN(C(=O)c3ccccc3Cl)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
505867 | 29710 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 460 | 8 | 0 | 4 | 4.8 | CCCN(c1ccccn1)C1CCN(C[C@H]2CN(C(=O)C3CCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL138645 | 29710 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 460 | 8 | 0 | 4 | 4.8 | CCCN(c1ccccn1)C1CCN(C[C@H]2CN(C(=O)C3CCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
72711280 | 92744 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 533 | 8 | 1 | 6 | 4.3 | Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccccn2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435900 | 92744 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 533 | 8 | 1 | 6 | 4.3 | Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccccn2)CC1 | 10.1021/jm401101p | |||
10205915 | 12809 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 441 | 11 | 1 | 3 | 4.4 | CCCN1C(=O)[C@@H](CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 | 10.1021/jm060051s | |||
CHEMBL1188208 | 12809 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 441 | 11 | 1 | 3 | 4.4 | CCCN1C(=O)[C@@H](CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 | 10.1021/jm060051s | |||
CHEMBL535616 | 12809 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 441 | 11 | 1 | 3 | 4.4 | CCCN1C(=O)[C@@H](CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 | 10.1021/jm060051s | |||
10116073 | 14409 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 469 | 7 | 1 | 4 | 4.3 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(C(=O)OCc1ccccc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1173708 | 14409 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 469 | 7 | 1 | 4 | 4.3 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(C(=O)OCc1ccccc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1200300 | 14409 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 469 | 7 | 1 | 4 | 4.3 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(C(=O)OCc1ccccc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
23577448 | 66648 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 563 | 9 | 3 | 6 | 4.2 | CCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813448 | 66648 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 563 | 9 | 3 | 6 | 4.2 | CCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1852753 | 66648 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 563 | 9 | 3 | 6 | 4.2 | CCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
3001322 | 443 | None | 22 | Rabbit | Functional | pIC50 | = | 4.5 | 4.5 | -75857 | 4 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmc.2011.05.022 | |||
805 | 443 | None | 22 | Rabbit | Functional | pIC50 | = | 4.5 | 4.5 | -75857 | 4 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1255794 | 443 | None | 22 | Rabbit | Functional | pIC50 | = | 4.5 | 4.5 | -75857 | 4 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmc.2011.05.022 | |||
DB06497 | 443 | None | 22 | Rabbit | Functional | pIC50 | = | 4.5 | 4.5 | -75857 | 4 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmc.2011.05.022 | |||
122185615 | 122977 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 526 | 6 | 2 | 2 | 6.0 | Cc1c(CNC(=O)c2ccc(C(C)(C)C)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(C(C)(C)C)cc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3604299 | 122977 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 526 | 6 | 2 | 2 | 6.0 | Cc1c(CNC(=O)c2ccc(C(C)(C)C)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(C(C)(C)C)cc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3606049 | 122977 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 526 | 6 | 2 | 2 | 6.0 | Cc1c(CNC(=O)c2ccc(C(C)(C)C)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(C(C)(C)C)cc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
3008925 | 100968 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 492 | 5 | 1 | 3 | 6.5 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2cccc3[nH]ccc23)CC1 | 10.1021/jm031046g | |||
CHEMBL293900 | 100968 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 492 | 5 | 1 | 3 | 6.5 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2cccc3[nH]ccc23)CC1 | 10.1021/jm031046g | |||
3008931 | 205104 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 559 | 6 | 0 | 5 | 7.1 | Cc1nc(-c2ccccc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL61374 | 205104 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 559 | 6 | 0 | 5 | 7.1 | Cc1nc(-c2ccccc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
71451541 | 81811 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 569 | 10 | 1 | 6 | 4.9 | Cc1ccncc1CN(C(=O)CC1CCOCC1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 | 10.1021/ml2002604 | |||
CHEMBL2164214 | 81811 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 569 | 10 | 1 | 6 | 4.9 | Cc1ccncc1CN(C(=O)CC1CCOCC1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 | 10.1021/ml2002604 | |||
168286382 | 191842 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 570 | 10 | 2 | 8 | 4.4 | CNS(=O)(=O)c1cccc(C(=O)N[C@@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)c2cccs2)c1 | 10.1021/acs.jmedchem.2c01383 | |||
CHEMBL5197247 | 191842 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 570 | 10 | 2 | 8 | 4.4 | CNS(=O)(=O)c1cccc(C(=O)N[C@@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)c2cccs2)c1 | 10.1021/acs.jmedchem.2c01383 | |||
46225513 | 203866 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 505 | 7 | 1 | 6 | 2.3 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C(C)(C)CO)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL604680 | 203866 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 505 | 7 | 1 | 6 | 2.3 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C(C)(C)CO)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
52943425 | 19074 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 812 | 13 | 3 | 6 | 6.2 | C=CCN(C(=O)NCc1ccc(C(N)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288915 | 19074 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 812 | 13 | 3 | 6 | 6.2 | C=CCN(C(=O)NCc1ccc(C(N)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
49864967 | 15786 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 620 | 11 | 1 | 8 | 4.7 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2cccc(OC)c2)CC1 | 10.1016/j.bmcl.2010.05.046 | |||
CHEMBL1222765 | 15786 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 620 | 11 | 1 | 8 | 4.7 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2cccc(OC)c2)CC1 | 10.1016/j.bmcl.2010.05.046 | |||
118727177 | 117445 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 494 | 8 | 0 | 4 | 4.0 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)c2ccccc2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
CHEMBL3397988 | 117445 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 494 | 8 | 0 | 4 | 4.0 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)c2ccccc2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
72711049 | 92738 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 557 | 8 | 1 | 6 | 4.8 | Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2cccc(C#N)c2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435894 | 92738 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 557 | 8 | 1 | 6 | 4.8 | Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2cccc(C#N)c2)CC1 | 10.1021/jm401101p | |||
49798920 | 14347 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 423 | 6 | 1 | 5 | 2.4 | COCC1NC(=O)C2(CCN(Cc3ccc(Oc4ccccc4)cc3)CC2)N(C)C1=O | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1171103 | 14347 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 423 | 6 | 1 | 5 | 2.4 | COCC1NC(=O)C2(CCN(Cc3ccc(Oc4ccccc4)cc3)CC2)N(C)C1=O | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1200062 | 14347 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 423 | 6 | 1 | 5 | 2.4 | COCC1NC(=O)C2(CCN(Cc3ccc(Oc4ccccc4)cc3)CC2)N(C)C1=O | 10.1016/j.bmc.2010.05.057 | |||
57331277 | 104635 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 584 | 10 | 0 | 4 | 5.2 | CCN(Cc1ccc(F)cc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
CHEMBL3104678 | 104635 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 584 | 10 | 0 | 4 | 5.2 | CCN(Cc1ccc(F)cc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
10204589 | 13048 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 419 | 6 | 1 | 3 | 3.6 | CC(C)C[C@@H]1NC(=O)C2(CCN(Cc3ccccc3)CC2)N(Cc2ccccc2)C1=O | 10.1021/jm060051s | |||
CHEMBL1189988 | 13048 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 419 | 6 | 1 | 3 | 3.6 | CC(C)C[C@@H]1NC(=O)C2(CCN(Cc3ccccc3)CC2)N(Cc2ccccc2)C1=O | 10.1021/jm060051s | |||
CHEMBL539854 | 13048 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 419 | 6 | 1 | 3 | 3.6 | CC(C)C[C@@H]1NC(=O)C2(CCN(Cc3ccccc3)CC2)N(Cc2ccccc2)C1=O | 10.1021/jm060051s | |||
56681915 | 66438 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 591 | 10 | 3 | 6 | 5.0 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813440 | 66438 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 591 | 10 | 3 | 6 | 5.0 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851889 | 66438 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 591 | 10 | 3 | 6 | 5.0 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
72714317 | 92731 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 546 | 8 | 1 | 5 | 5.2 | Cc1ccccc1C1CN(C2CCCCC2)C(=O)N1C1CCN(C(C)CCNC(=O)c2c(C)ncnc2C)CC1 | 10.1021/jm401101p | |||
CHEMBL2435887 | 92731 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 546 | 8 | 1 | 5 | 5.2 | Cc1ccccc1C1CN(C2CCCCC2)C(=O)N1C1CCN(C(C)CCNC(=O)c2c(C)ncnc2C)CC1 | 10.1021/jm401101p | |||
122668167 | 165969 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 523 | 9 | 1 | 6 | 5.9 | Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)Cc2ccc(F)cc2)s1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4249259 | 165969 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 523 | 9 | 1 | 6 | 5.9 | Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)Cc2ccc(F)cc2)s1 | 10.1021/acs.jmedchem.8b01077 | |||
16659334 | 14009 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 493 | 9 | 2 | 5 | 4.0 | CCCCN1C(=O)[C@@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
CHEMBL1197042 | 14009 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 493 | 9 | 2 | 5 | 4.0 | CCCCN1C(=O)[C@@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
CHEMBL559168 | 14009 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 493 | 9 | 2 | 5 | 4.0 | CCCCN1C(=O)[C@@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
21064295 | 14334 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 574 | 10 | 2 | 5 | 5.3 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1170875 | 14334 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 574 | 10 | 2 | 5 | 5.3 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1200016 | 14334 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 574 | 10 | 2 | 5 | 5.3 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
505870 | 27635 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 500 | 8 | 0 | 4 | 5.6 | O=C(C1CCCCC1)N1C[C@H](CN2CCC(N(CC3CC3)c3ccccn3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL136977 | 27635 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 500 | 8 | 0 | 4 | 5.6 | O=C(C1CCCCC1)N1C[C@H](CN2CCC(N(CC3CC3)c3ccccn3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/s0960-894x(02)00988-5 | |||
505880 | 27730 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 519 | 10 | 1 | 6 | 4.9 | CCCN(c1ncccn1)C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL137038 | 27730 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 519 | 10 | 1 | 6 | 4.9 | CCCN(c1ncccn1)C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
505879 | 28655 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 518 | 10 | 1 | 5 | 5.5 | CCCN(c1cccnc1)C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL137728 | 28655 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 518 | 10 | 1 | 5 | 5.5 | CCCN(c1cccnc1)C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
505881 | 29459 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 537 | 10 | 1 | 6 | 5.0 | CCCN(c1ncccn1)C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL138437 | 29459 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 537 | 10 | 1 | 6 | 5.0 | CCCN(c1ncccn1)C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
44357063 | 119208 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 523 | 11 | 1 | 6 | 4.7 | CCCN(c1ccncn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL342842 | 119208 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 523 | 11 | 1 | 6 | 4.7 | CCCN(c1ccncn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
44357079 | 119405 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 541 | 11 | 1 | 6 | 4.8 | CCCN(c1ncc(F)cn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL344261 | 119405 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 541 | 11 | 1 | 6 | 4.8 | CCCN(c1ncc(F)cn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
118727185 | 117453 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 604 | 9 | 0 | 4 | 6.3 | Cc1ccc(N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)C(=O)C2CCN(C(=O)c3ccccc3)CC2)cc1Cl | 10.1016/j.bmc.2014.12.052 | |||
CHEMBL3397996 | 117453 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 604 | 9 | 0 | 4 | 6.3 | Cc1ccc(N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)C(=O)C2CCN(C(=O)c3ccccc3)CC2)cc1Cl | 10.1016/j.bmc.2014.12.052 | |||
10118535 | 14326 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 477 | 8 | 1 | 4 | 4.8 | CC(C)CC1NC(=O)C2(CCN(Cc3ccc(Oc4ccccc4)cc3)CC2)N(CC(C)C)C1=O | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1170471 | 14326 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 477 | 8 | 1 | 4 | 4.8 | CC(C)CC1NC(=O)C2(CCN(Cc3ccc(Oc4ccccc4)cc3)CC2)N(CC(C)C)C1=O | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1199972 | 14326 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 477 | 8 | 1 | 4 | 4.8 | CC(C)CC1NC(=O)C2(CCN(Cc3ccc(Oc4ccccc4)cc3)CC2)N(CC(C)C)C1=O | 10.1016/j.bmc.2010.05.057 | |||
23577409 | 66439 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 563 | 10 | 3 | 6 | 4.2 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813439 | 66439 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 563 | 10 | 3 | 6 | 4.2 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851891 | 66439 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 563 | 10 | 3 | 6 | 4.2 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
23577328 | 66455 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 592 | 10 | 3 | 7 | 3.1 | CNC(=O)c1ccc(Oc2ccc(CN3CCC4(CC3)C(=O)N[C@H]([C@H](O)C3CCCCC3)C(=O)N4CCOC)cc2)cc1 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813454 | 66455 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 592 | 10 | 3 | 7 | 3.1 | CNC(=O)c1ccc(Oc2ccc(CN3CCC4(CC3)C(=O)N[C@H]([C@H](O)C3CCCCC3)C(=O)N4CCOC)cc2)cc1 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851967 | 66455 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 592 | 10 | 3 | 7 | 3.1 | CNC(=O)c1ccc(Oc2ccc(CN3CCC4(CC3)C(=O)N[C@H]([C@H](O)C3CCCCC3)C(=O)N4CCOC)cc2)cc1 | 10.1016/j.bmc.2011.05.022 | |||
46225345 | 202495 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 549 | 6 | 0 | 5 | 4.6 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)CC(C)(C)C)CC3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL595559 | 202495 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 549 | 6 | 0 | 5 | 4.6 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)CC(C)(C)C)CC3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
11192476 | 69220 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 578 | 9 | 1 | 4 | 7.1 | CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2ccccc2)c2ccc(C(F)(F)F)cc2)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926872 | 69220 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 578 | 9 | 1 | 4 | 7.1 | CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2ccccc2)c2ccc(C(F)(F)F)cc2)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
52947090 | 19068 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 773 | 11 | 2 | 5 | 7.6 | C=CCN(C(=O)Nc1ccc(F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288909 | 19068 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 773 | 11 | 2 | 5 | 7.6 | C=CCN(C(=O)Nc1ccc(F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
3001322 | 443 | None | 22 | Human | Functional | pIC50 | = | 7.5 | 7.5 | -123 | 4 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmcl.2010.12.109 | |||
805 | 443 | None | 22 | Human | Functional | pIC50 | = | 7.5 | 7.5 | -123 | 4 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL1255794 | 443 | None | 22 | Human | Functional | pIC50 | = | 7.5 | 7.5 | -123 | 4 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmcl.2010.12.109 | |||
DB06497 | 443 | None | 22 | Human | Functional | pIC50 | = | 7.5 | 7.5 | -123 | 4 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmcl.2010.12.109 | |||
11597 | 674 | None | 6 | Human | Functional | pIC50 | = | 7.5 | 7.5 | -11 | 2 | ChEMBL | 506 | 5 | 3 | 6 | 3.5 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C | 10.1021/acsmedchemlett.1c00373 | |||
23725180 | 674 | None | 6 | Human | Functional | pIC50 | = | 7.5 | 7.5 | -11 | 2 | ChEMBL | 506 | 5 | 3 | 6 | 3.5 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C | 10.1021/acsmedchemlett.1c00373 | |||
CHEMBL4781426 | 674 | None | 6 | Human | Functional | pIC50 | = | 7.5 | 7.5 | -11 | 2 | ChEMBL | 506 | 5 | 3 | 6 | 3.5 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C | 10.1021/acsmedchemlett.1c00373 | |||
23577388 | 66399 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 611 | 10 | 2 | 7 | 4.3 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(S(C)(=O)=O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813434 | 66399 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 611 | 10 | 2 | 7 | 4.3 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(S(C)(=O)=O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851692 | 66399 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 611 | 10 | 2 | 7 | 4.3 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(S(C)(=O)=O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
52943424 | 19072 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 833 | 12 | 2 | 7 | 6.8 | C=CCN(C(=O)Nc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288913 | 19072 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 833 | 12 | 2 | 7 | 6.8 | C=CCN(C(=O)Nc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
21926130 | 14389 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 519 | 8 | 1 | 5 | 4.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1c(C)nn(-c3ccccc3)c1C)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1200253 | 14389 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 519 | 8 | 1 | 5 | 4.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1c(C)nn(-c3ccccc3)c1C)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL3216711 | 14389 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 519 | 8 | 1 | 5 | 4.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1c(C)nn(-c3ccccc3)c1C)CC2 | 10.1016/j.bmc.2010.05.057 | |||
57331276 | 104640 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 556 | 9 | 1 | 4 | 4.5 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCc3ccc(F)cc3)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
CHEMBL3104683 | 104640 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 556 | 9 | 1 | 4 | 4.5 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCc3ccc(F)cc3)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
3008905 | 201174 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 537 | 6 | 0 | 5 | 5.0 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccc(C#N)cc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL58248 | 201174 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 537 | 6 | 0 | 5 | 5.0 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccc(C#N)cc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
23577362 | 66397 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 612 | 10 | 3 | 7 | 3.5 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(S(N)(=O)=O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813433 | 66397 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 612 | 10 | 3 | 7 | 3.5 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(S(N)(=O)=O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851690 | 66397 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | ChEMBL | 612 | 10 | 3 | 7 | 3.5 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(S(N)(=O)=O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
56678578 | 66424 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 618 | 12 | 3 | 6 | 5.0 | CCCCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813451 | 66424 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 618 | 12 | 3 | 6 | 5.0 | CCCCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851823 | 66424 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 618 | 12 | 3 | 6 | 5.0 | CCCCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
46225429 | 202541 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 527 | 5 | 0 | 5 | 4.2 | Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C(C)(C)C)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL595902 | 202541 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 527 | 5 | 0 | 5 | 4.2 | Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C(C)(C)C)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
46225348 | 202628 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 515 | 6 | 0 | 5 | 3.8 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C4CCCC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL596519 | 202628 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 515 | 6 | 0 | 5 | 3.8 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C4CCCC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
46225347 | 202500 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 559 | 5 | 0 | 5 | 4.7 | Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)(C)C)CC3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL595584 | 202500 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 559 | 5 | 0 | 5 | 4.7 | Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)(C)C)CC3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
44356876 | 28050 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 554 | 8 | 0 | 4 | 6.4 | C=CCN(c1ccc(C(F)(F)F)cn1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL137272 | 28050 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 554 | 8 | 0 | 4 | 6.4 | C=CCN(c1ccc(C(F)(F)F)cn1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
44129650 | 10821 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 623 | 10 | 1 | 7 | 4.2 | C=CCN(C(=O)OCc1ccc(S(C)(=O)=O)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172040 | 10821 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 623 | 10 | 1 | 7 | 4.2 | C=CCN(C(=O)OCc1ccc(S(C)(=O)=O)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
49798084 | 10812 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 544 | 9 | 2 | 4 | 4.4 | C=CCN(C(=O)NCc1ccccc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1171966 | 10812 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 544 | 9 | 2 | 4 | 4.4 | C=CCN(C(=O)NCc1ccccc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
56676455 | 66472 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 456 | 18 | 0 | 0 | 9.7 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL1817916 | 66472 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 456 | 18 | 0 | 0 | 9.7 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL1852060 | 66472 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 456 | 18 | 0 | 0 | 9.7 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL2057819 | 66472 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 456 | 18 | 0 | 0 | 9.7 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.bmcl.2012.05.127 | |||
56676455 | 66472 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 456 | 18 | 0 | 0 | 9.7 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL1817916 | 66472 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 456 | 18 | 0 | 0 | 9.7 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL1852060 | 66472 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 456 | 18 | 0 | 0 | 9.7 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL2057819 | 66472 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 456 | 18 | 0 | 0 | 9.7 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.bmcl.2011.07.058 | |||
46225530 | 202123 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 550 | 6 | 0 | 4 | 4.7 | Cc1ccnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL592997 | 202123 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 550 | 6 | 0 | 4 | 4.7 | Cc1ccnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
46225527 | 202150 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 571 | 6 | 0 | 6 | 3.3 | Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCOC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL593184 | 202150 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 571 | 6 | 0 | 6 | 3.3 | Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCOC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
49864970 | 15789 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 630 | 9 | 2 | 4 | 5.5 | C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2010.05.046 | |||
CHEMBL1222768 | 15789 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 630 | 9 | 2 | 4 | 5.5 | C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2010.05.046 | |||
11947758 | 60140 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL1668021 | 60140 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL1739499 | 60140 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
23577382 | 66459 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 590 | 10 | 3 | 6 | 4.2 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813432 | 66459 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 590 | 10 | 3 | 6 | 4.2 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851977 | 66459 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 590 | 10 | 3 | 6 | 4.2 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
122185619 | 122979 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 570 | 6 | 2 | 2 | 4.9 | Cc1c(CNC(=O)c2ccc(Br)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(Br)cc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3604301 | 122979 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 570 | 6 | 2 | 2 | 4.9 | Cc1c(CNC(=O)c2ccc(Br)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(Br)cc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3606051 | 122979 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 570 | 6 | 2 | 2 | 4.9 | Cc1c(CNC(=O)c2ccc(Br)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(Br)cc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
57392302 | 69228 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 618 | 10 | 1 | 5 | 6.8 | COc1cccc(CN(c2ccc(Br)cc2)C2CCN(C(C)CCNC(=O)c3c(Cl)cncc3Cl)CC2)c1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926882 | 69228 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 618 | 10 | 1 | 5 | 6.8 | COc1cccc(CN(c2ccc(Br)cc2)C2CCN(C(C)CCNC(=O)c3c(Cl)cncc3Cl)CC2)c1 | 10.1016/j.bmcl.2011.09.133 | |||
73355553 | 92845 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 417 | 6 | 2 | 6 | 3.7 | COc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.ejmech.2013.09.004 | |||
CHEMBL2436816 | 92845 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 417 | 6 | 2 | 6 | 3.7 | COc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.ejmech.2013.09.004 | |||
56681917 | 66457 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 604 | 11 | 3 | 6 | 4.6 | CCCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813450 | 66457 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 604 | 11 | 3 | 6 | 4.6 | CCCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851972 | 66457 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 604 | 11 | 3 | 6 | 4.6 | CCCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
23577360 | 66394 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 576 | 10 | 3 | 6 | 4.0 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(N)=O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813271 | 66394 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 576 | 10 | 3 | 6 | 4.0 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(N)=O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851675 | 66394 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 576 | 10 | 3 | 6 | 4.0 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(N)=O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
162659856 | 181344 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 914 | 27 | 5 | 11 | 5.6 | CNC(=O)COCC(=O)NCCCCCCCCCNC(=O)COCC(=O)Nc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)cc1 | 10.1016/j.bmc.2016.09.059 | |||
CHEMBL4761614 | 181344 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 914 | 27 | 5 | 11 | 5.6 | CNC(=O)COCC(=O)NCCCCCCCCCNC(=O)COCC(=O)Nc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)cc1 | 10.1016/j.bmc.2016.09.059 | |||
162658125 | 181202 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -100 | 3 | ChEMBL | 471 | 6 | 2 | 4 | 5.9 | O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
CHEMBL4760108 | 181202 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -100 | 3 | ChEMBL | 471 | 6 | 2 | 4 | 5.9 | O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
162666730 | 182380 | None | 1 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -562 | 3 | ChEMBL | 589 | 9 | 2 | 6 | 6.5 | N#CSCCNC(=O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
CHEMBL4783861 | 182380 | None | 1 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -562 | 3 | ChEMBL | 589 | 9 | 2 | 6 | 6.5 | N#CSCCNC(=O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | |||
145984591 | 166016 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 587 | 8 | 1 | 6 | 7.0 | Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C(C)C)nnc2C(F)(F)F)C3)NC(=O)C2CCC(F)(F)CC2)s1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4250366 | 166016 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 587 | 8 | 1 | 6 | 7.0 | Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C(C)C)nnc2C(F)(F)F)C3)NC(=O)C2CCC(F)(F)CC2)s1 | 10.1021/acs.jmedchem.8b01077 | |||
49798158 | 10889 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 607 | 10 | 1 | 6 | 3.6 | C=CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172623 | 10889 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 607 | 10 | 1 | 6 | 3.6 | C=CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
11585625 | 77112 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 648 | 10 | 1 | 6 | 4.0 | CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(NS(=O)(=O)c3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
CHEMBL207447 | 77112 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 648 | 10 | 1 | 6 | 4.0 | CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(NS(=O)(=O)c3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
72712598 | 92692 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 591 | 5 | 0 | 4 | 6.6 | Cc1cc(Cl)nc(C)c1C(=O)N1CCC(C)(N2CCC(N3C(=O)N(C4CCCCC4)C[C@H]3c3ccccc3)CC2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435848 | 92692 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 591 | 5 | 0 | 4 | 6.6 | Cc1cc(Cl)nc(C)c1C(=O)N1CCC(C)(N2CCC(N3C(=O)N(C4CCCCC4)C[C@H]3c3ccccc3)CC2)CC1 | 10.1021/jm401101p | |||
50992246 | 58488 | None | 2 | Human | Functional | pIC50 | = | 8.4 | 8.4 | -1 | 5 | ChEMBL | 498 | 6 | 1 | 6 | 3.3 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.015 | |||
CHEMBL1683074 | 58488 | None | 2 | Human | Functional | pIC50 | = | 8.4 | 8.4 | -1 | 5 | ChEMBL | 498 | 6 | 1 | 6 | 3.3 | CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(C)C)C1 | 10.1016/j.bmcl.2011.01.015 | |||
168276745 | 190707 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 503 | 8 | 1 | 6 | 6.0 | Cc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCCC1)c1ccsc1Cl | 10.1021/acs.jmedchem.2c01383 | |||
CHEMBL5180628 | 190707 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 503 | 8 | 1 | 6 | 6.0 | Cc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCCC1)c1ccsc1Cl | 10.1021/acs.jmedchem.2c01383 | |||
72714076 | 92727 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 532 | 8 | 1 | 5 | 4.9 | Cc1ncnc(C)c1C(=O)NCC[C@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435883 | 92727 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 532 | 8 | 1 | 5 | 4.9 | Cc1ncnc(C)c1C(=O)NCC[C@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
52943390 | 19064 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 795 | 12 | 1 | 7 | 7.4 | C=CCN(C(=O)OCc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288877 | 19064 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 795 | 12 | 1 | 7 | 7.4 | C=CCN(C(=O)OCc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
52943389 | 19063 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 848 | 13 | 1 | 8 | 7.0 | C=CCN(C(=O)OCc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288876 | 19063 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 848 | 13 | 1 | 8 | 7.0 | C=CCN(C(=O)OCc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
145986145 | 165584 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 573 | 8 | 1 | 6 | 6.7 | CC(C)c1nnc(C(F)(F)F)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cccs1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4240242 | 165584 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 573 | 8 | 1 | 6 | 6.7 | CC(C)c1nnc(C(F)(F)F)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cccs1 | 10.1021/acs.jmedchem.8b01077 | |||
72711277 | 92741 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 560 | 8 | 1 | 5 | 5.5 | Cc1cc(C)cc(C2CN(C3CCCCC3)C(=O)N2C2CCN(C(C)CCNC(=O)c3c(C)ncnc3C)CC2)c1 | 10.1021/jm401101p | |||
CHEMBL2435897 | 92741 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 560 | 8 | 1 | 5 | 5.5 | Cc1cc(C)cc(C2CN(C3CCCCC3)C(=O)N2C2CCN(C(C)CCNC(=O)c3c(C)ncnc3C)CC2)c1 | 10.1021/jm401101p | |||
44511861 | 69241 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 549 | 10 | 1 | 6 | 5.7 | COc1ccc(N(Cc2cnccc2C)C2CCN([C@@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926895 | 69241 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 549 | 10 | 1 | 6 | 5.7 | COc1ccc(N(Cc2cnccc2C)C2CCN([C@@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
52944586 | 19060 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 838 | 12 | 1 | 6 | 8.6 | C=CCN(C(=O)OCc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288873 | 19060 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 838 | 12 | 1 | 6 | 8.6 | C=CCN(C(=O)OCc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
21064299 | 14335 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 610 | 11 | 2 | 6 | 5.3 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(NS(C)(=O)=O)cc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1170876 | 14335 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 610 | 11 | 2 | 6 | 5.3 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(NS(C)(=O)=O)cc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1200017 | 14335 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 610 | 11 | 2 | 6 | 5.3 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(NS(C)(=O)=O)cc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
168275071 | 190559 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 534 | 9 | 2 | 7 | 5.5 | CC(=O)Nc1cccc(C(=O)N[C@@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)c2cccs2)c1 | 10.1021/acs.jmedchem.2c01383 | |||
CHEMBL5178495 | 190559 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 534 | 9 | 2 | 7 | 5.5 | CC(=O)Nc1cccc(C(=O)N[C@@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)c2cccs2)c1 | 10.1021/acs.jmedchem.2c01383 | |||
70685193 | 73149 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 410 | 6 | 0 | 4 | 5.6 | Cc1nc2cnccc2n1C1CCN(CCC(c2ccccc2)c2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00180 | |||
CHEMBL2011438 | 73149 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 410 | 6 | 0 | 4 | 5.6 | Cc1nc2cnccc2n1C1CCN(CCC(c2ccccc2)c2ccccc2)CC1 | 10.1021/acs.jmedchem.8b00180 | |||
9956238 | 60218 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | -3 | 4 | ChEMBL | 467 | 8 | 2 | 8 | 3.0 | Cc1nn(C)c2nc(N(C)CCN(C)C)c(C(=O)NC(=O)Nc3cccc(OC(C)C)c3)cc12 | 10.1021/jm1012903 | |||
CHEMBL1688889 | 60218 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | -3 | 4 | ChEMBL | 467 | 8 | 2 | 8 | 3.0 | Cc1nn(C)c2nc(N(C)CCN(C)C)c(C(=O)NC(=O)Nc3cccc(OC(C)C)c3)cc12 | 10.1021/jm1012903 | |||
CHEMBL1739922 | 60218 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | -3 | 4 | ChEMBL | 467 | 8 | 2 | 8 | 3.0 | Cc1nn(C)c2nc(N(C)CCN(C)C)c(C(=O)NC(=O)Nc3cccc(OC(C)C)c3)cc12 | 10.1021/jm1012903 | |||
10208679 | 12846 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 493 | 9 | 2 | 5 | 4.0 | CCCCN1C(=O)[C@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
CHEMBL1188565 | 12846 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 493 | 9 | 2 | 5 | 4.0 | CCCCN1C(=O)[C@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
CHEMBL536751 | 12846 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 493 | 9 | 2 | 5 | 4.0 | CCCCN1C(=O)[C@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
3008921 | 168335 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 459 | 5 | 0 | 3 | 6.3 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)C2CCCCC2)CC1 | 10.1021/jm031046g | |||
CHEMBL433635 | 168335 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 459 | 5 | 0 | 3 | 6.3 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)C2CCCCC2)CC1 | 10.1021/jm031046g | |||
52940989 | 19062 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 828 | 13 | 1 | 8 | 7.3 | C=CCN(C(=O)OCc1ccc(C(=O)OC)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288875 | 19062 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 828 | 13 | 1 | 8 | 7.3 | C=CCN(C(=O)OCc1ccc(C(=O)OC)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
3008933 | 204088 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 531 | 6 | 0 | 4 | 6.5 | Cc1cc(C)c(S(=O)(=O)N2CCC(C)(N3CCC(N(c4ccccc4)c4ccccc4)CC3)CC2)c(C)c1 | 10.1021/jm031046g | |||
CHEMBL60589 | 204088 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 531 | 6 | 0 | 4 | 6.5 | Cc1cc(C)c(S(=O)(=O)N2CCC(C)(N3CCC(N(c4ccccc4)c4ccccc4)CC3)CC2)c(C)c1 | 10.1021/jm031046g | |||
90656335 | 111134 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 475 | 8 | 2 | 7 | 3.5 | CC(C)Oc1ccc(N2CCN(Cc3ccc(C(=O)O)cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.bmcl.2014.03.073 | |||
CHEMBL3263031 | 111134 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 475 | 8 | 2 | 7 | 3.5 | CC(C)Oc1ccc(N2CCN(Cc3ccc(C(=O)O)cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.bmcl.2014.03.073 | |||
52944587 | 19067 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 837 | 12 | 2 | 5 | 8.1 | C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288880 | 19067 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 837 | 12 | 2 | 5 | 8.1 | C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
49799711 | 14412 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 533 | 9 | 2 | 5 | 5.6 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(O)cc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1173712 | 14412 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 533 | 9 | 2 | 5 | 5.6 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(O)cc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1200303 | 14412 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 533 | 9 | 2 | 5 | 5.6 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(O)cc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
46226128 | 14119 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 547 | 10 | 2 | 5 | 5.7 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(O)cc3)c1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL1198003 | 14119 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 547 | 10 | 2 | 5 | 5.7 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(O)cc3)c1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL592944 | 14119 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 547 | 10 | 2 | 5 | 5.7 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(O)cc3)c1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
3008922 | 201164 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 513 | 7 | 0 | 5 | 6.0 | COc1cccc(OC)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL58176 | 201164 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 513 | 7 | 0 | 5 | 6.0 | COc1cccc(OC)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
52942223 | 19081 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 810 | 14 | 1 | 6 | 7.1 | C=CCN(C(=O)CCc1ccc(OC(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288922 | 19081 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 810 | 14 | 1 | 6 | 7.1 | C=CCN(C(=O)CCc1ccc(OC(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
3008912 | 203529 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 458 | 4 | 1 | 4 | 5.4 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc4ccn(C)c4c3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL60279 | 203529 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 458 | 4 | 1 | 4 | 5.4 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc4ccn(C)c4c3)CC2)CC1 | 10.1021/jm031046g | |||
72712371 | 92715 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 494 | 6 | 0 | 3 | 6.5 | O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(-c3ccncc3)cc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435871 | 92715 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 494 | 6 | 0 | 3 | 6.5 | O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(-c3ccncc3)cc2)CC1 | 10.1021/jm401101p | |||
10278617 | 95235 | None | 3 | Human | Functional | pIC50 | = | 7.4 | 7.4 | 1 | 2 | ChEMBL | 499 | 5 | 0 | 5 | 4.6 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1 | 10.1016/j.bmcl.2008.01.108 | |||
CHEMBL255858 | 95235 | None | 3 | Human | Functional | pIC50 | = | 7.4 | 7.4 | 1 | 2 | ChEMBL | 499 | 5 | 0 | 5 | 4.6 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1 | 10.1016/j.bmcl.2008.01.108 | |||
72712372 | 92716 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 499 | 6 | 0 | 6 | 4.7 | Cn1nnc(-c2ccc(CN3CCC(N4C(=O)N(C5CCCCC5)C[C@H]4c4ccccc4)CC3)cc2)n1 | 10.1021/jm401101p | |||
CHEMBL2435872 | 92716 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 499 | 6 | 0 | 6 | 4.7 | Cn1nnc(-c2ccc(CN3CCC(N4C(=O)N(C5CCCCC5)C[C@H]4c4ccccc4)CC3)cc2)n1 | 10.1021/jm401101p | |||
73355554 | 92852 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 431 | 7 | 2 | 6 | 4.1 | CCOc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.ejmech.2013.09.004 | |||
CHEMBL2436824 | 92852 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 431 | 7 | 2 | 6 | 4.1 | CCOc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.ejmech.2013.09.004 | |||
53324598 | 60132 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL1668020 | 60132 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL1739382 | 60132 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
5275761 | 77147 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 609 | 10 | 1 | 5 | 5.0 | CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(C(=O)O)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
CHEMBL207633 | 77147 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 609 | 10 | 1 | 5 | 5.0 | CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(C(=O)O)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
53324598 | 60132 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1668020 | 60132 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1739382 | 60132 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
6320546 | 60143 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL1668022 | 60143 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL1739500 | 60143 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
168295761 | 192570 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 497 | 9 | 1 | 10 | 3.2 | Cc1ccc([C@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)Cn2cnnn2)s1 | 10.1021/acs.jmedchem.2c01383 | |||
CHEMBL5208613 | 192570 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 497 | 9 | 1 | 10 | 3.2 | Cc1ccc([C@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)Cn2cnnn2)s1 | 10.1021/acs.jmedchem.2c01383 | |||
21064338 | 14405 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 506 | 8 | 1 | 5 | 5.1 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1nc(-c3ccccc3)oc1C)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1173645 | 14405 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 506 | 8 | 1 | 5 | 5.1 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1nc(-c3ccccc3)oc1C)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1200293 | 14405 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 506 | 8 | 1 | 5 | 5.1 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1nc(-c3ccccc3)oc1C)CC2 | 10.1016/j.bmc.2010.05.057 | |||
44356952 | 119340 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 591 | 11 | 1 | 6 | 5.7 | CCCN(c1nccc(C(F)(F)F)n1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL343745 | 119340 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 591 | 11 | 1 | 6 | 5.7 | CCCN(c1nccc(C(F)(F)F)n1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
73349498 | 92820 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 473 | 8 | 1 | 5 | 6.0 | CC(C)Oc1ccc(C2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1ccccc1 | 10.1016/j.ejmech.2013.09.004 | |||
CHEMBL2436712 | 92820 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | ChEMBL | 473 | 8 | 1 | 5 | 6.0 | CC(C)Oc1ccc(C2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1ccccc1 | 10.1016/j.ejmech.2013.09.004 | |||
3008919 | 100819 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 453 | 5 | 0 | 3 | 6.0 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2ccccc2)CC1 | 10.1021/jm031046g | |||
CHEMBL292894 | 100819 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 453 | 5 | 0 | 3 | 6.0 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2ccccc2)CC1 | 10.1021/jm031046g | |||
46225514 | 202281 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 537 | 7 | 0 | 6 | 3.0 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(S(=O)(=O)C4CCCC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL594208 | 202281 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 537 | 7 | 0 | 6 | 3.0 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(S(=O)(=O)C4CCCC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
90656337 | 111135 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 509 | 8 | 1 | 8 | 3.2 | CC(C)Oc1ccc(N2CCN(Cc3ccc(S(C)(=O)=O)cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.bmcl.2014.03.073 | |||
CHEMBL3263033 | 111135 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 509 | 8 | 1 | 8 | 3.2 | CC(C)Oc1ccc(N2CCN(Cc3ccc(S(C)(=O)=O)cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.bmcl.2014.03.073 | |||
90656338 | 111136 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 445 | 7 | 1 | 6 | 4.1 | Cc1ccc(CN2CCN(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 | 10.1016/j.bmcl.2014.03.073 | |||
CHEMBL3263034 | 111136 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 445 | 7 | 1 | 6 | 4.1 | Cc1ccc(CN2CCN(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 | 10.1016/j.bmcl.2014.03.073 | |||
52944086 | 19069 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 787 | 12 | 2 | 5 | 7.3 | C=CCN(C(=O)NCc1ccc(F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288910 | 19069 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 787 | 12 | 2 | 5 | 7.3 | C=CCN(C(=O)NCc1ccc(F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
46225349 | 202506 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 539 | 6 | 0 | 5 | 4.3 | Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C4CCCC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL595610 | 202506 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 539 | 6 | 0 | 5 | 4.3 | Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C4CCCC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
3001322 | 443 | None | 22 | Human | Functional | pIC50 | = | 7.3 | 7.3 | -123 | 4 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmc.2011.05.022 | |||
805 | 443 | None | 22 | Human | Functional | pIC50 | = | 7.3 | 7.3 | -123 | 4 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1255794 | 443 | None | 22 | Human | Functional | pIC50 | = | 7.3 | 7.3 | -123 | 4 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmc.2011.05.022 | |||
DB06497 | 443 | None | 22 | Human | Functional | pIC50 | = | 7.3 | 7.3 | -123 | 4 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmc.2011.05.022 | |||
3008910 | 202088 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 481 | 5 | 1 | 3 | 6.5 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(-c4ccccc4)cc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL59285 | 202088 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 481 | 5 | 1 | 3 | 6.5 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(-c4ccccc4)cc3)CC2)CC1 | 10.1021/jm031046g | |||
53389083 | 66467 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 438 | 16 | 0 | 0 | 9.5 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL1817912 | 66467 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 438 | 16 | 0 | 0 | 9.5 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL1852020 | 66467 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 438 | 16 | 0 | 0 | 9.5 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL2057816 | 66467 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 438 | 16 | 0 | 0 | 9.5 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.bmcl.2012.05.127 | |||
53389083 | 66467 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 438 | 16 | 0 | 0 | 9.5 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL1817912 | 66467 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 438 | 16 | 0 | 0 | 9.5 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL1852020 | 66467 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 438 | 16 | 0 | 0 | 9.5 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL2057816 | 66467 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 438 | 16 | 0 | 0 | 9.5 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCC2 | 10.1016/j.bmcl.2011.07.058 | |||
56661530 | 66458 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 616 | 8 | 3 | 6 | 4.0 | CNC(=O)c1ccc(Oc2ccc(CN3CCC4(CC3)C(=O)N[C@H]([C@H](O)C3CCCCC3)C(=O)N4CC(F)(F)F)cc2)cc1 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813457 | 66458 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 616 | 8 | 3 | 6 | 4.0 | CNC(=O)c1ccc(Oc2ccc(CN3CCC4(CC3)C(=O)N[C@H]([C@H](O)C3CCCCC3)C(=O)N4CC(F)(F)F)cc2)cc1 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851975 | 66458 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 616 | 8 | 3 | 6 | 4.0 | CNC(=O)c1ccc(Oc2ccc(CN3CCC4(CC3)C(=O)N[C@H]([C@H](O)C3CCCCC3)C(=O)N4CC(F)(F)F)cc2)cc1 | 10.1016/j.bmc.2011.05.022 | |||
122185621 | 122980 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 482 | 6 | 2 | 2 | 4.7 | Cc1c(CNC(=O)c2ccc(Cl)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(Cl)cc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3604302 | 122980 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 482 | 6 | 2 | 2 | 4.7 | Cc1c(CNC(=O)c2ccc(Cl)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(Cl)cc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3606052 | 122980 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 482 | 6 | 2 | 2 | 4.7 | Cc1c(CNC(=O)c2ccc(Cl)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(Cl)cc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
11947758 | 60140 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL1668021 | 60140 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL1739499 | 60140 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
73346462 | 92853 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 473 | 8 | 2 | 6 | 4.5 | CCOc1ccc(C2CCN(Cc3ccc(NC(C)=O)cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.ejmech.2013.09.004 | |||
CHEMBL2436825 | 92853 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 473 | 8 | 2 | 6 | 4.5 | CCOc1ccc(C2CCN(Cc3ccc(NC(C)=O)cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.ejmech.2013.09.004 | |||
57331308 | 104637 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 591 | 10 | 0 | 5 | 5.0 | CCN(Cc1ccc(C#N)cc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
CHEMBL3104680 | 104637 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 591 | 10 | 0 | 5 | 5.0 | CCN(Cc1ccc(C#N)cc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
3008926 | 204303 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 492 | 5 | 1 | 3 | 6.5 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2c[nH]c3ccccc23)CC1 | 10.1021/jm031046g | |||
CHEMBL60711 | 204303 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 492 | 5 | 1 | 3 | 6.5 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2c[nH]c3ccccc23)CC1 | 10.1021/jm031046g | |||
3008937 | 202556 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 469 | 5 | 0 | 5 | 5.0 | Cc1ncnc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL59602 | 202556 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 469 | 5 | 0 | 5 | 5.0 | Cc1ncnc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
15942352 | 81801 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 505 | 8 | 1 | 5 | 4.6 | Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)N(C)C)CC1 | 10.1021/ml2002604 | |||
CHEMBL2164204 | 81801 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 505 | 8 | 1 | 5 | 4.6 | Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)N(C)C)CC1 | 10.1021/ml2002604 | |||
86294766 | 110744 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 502 | 10 | 1 | 7 | 4.7 | CCN(CC)c1ccc(CN2CCN(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 | 10.1016/j.bmcl.2014.03.073 | |||
CHEMBL3259855 | 110744 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 502 | 10 | 1 | 7 | 4.7 | CCN(CC)c1ccc(CN2CCN(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 | 10.1016/j.bmcl.2014.03.073 | |||
23577362 | 66397 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 612 | 10 | 3 | 7 | 3.5 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(S(N)(=O)=O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813433 | 66397 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 612 | 10 | 3 | 7 | 3.5 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(S(N)(=O)=O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851690 | 66397 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 612 | 10 | 3 | 7 | 3.5 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(S(N)(=O)=O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
10230510 | 66437 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 537 | 10 | 3 | 6 | 3.7 | CCCCN1C(=O)[C@@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813436 | 66437 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 537 | 10 | 3 | 6 | 3.7 | CCCCN1C(=O)[C@@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851888 | 66437 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 537 | 10 | 3 | 6 | 3.7 | CCCCN1C(=O)[C@@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
56659272 | 66492 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 452 | 16 | 0 | 0 | 9.8 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL1817915 | 66492 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 452 | 16 | 0 | 0 | 9.8 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL1852160 | 66492 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 452 | 16 | 0 | 0 | 9.8 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL2057817 | 66492 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 452 | 16 | 0 | 0 | 9.8 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.bmcl.2011.07.058 | |||
56659272 | 66492 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 452 | 16 | 0 | 0 | 9.8 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL1817915 | 66492 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 452 | 16 | 0 | 0 | 9.8 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL1852160 | 66492 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 452 | 16 | 0 | 0 | 9.8 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL2057817 | 66492 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 452 | 16 | 0 | 0 | 9.8 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.bmcl.2012.05.127 | |||
54581479 | 60906 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 588 | 9 | 1 | 4 | 6.8 | CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2ccccc2)c2ccc(Br)cc2)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1762313 | 60906 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 588 | 9 | 1 | 4 | 6.8 | CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2ccccc2)c2ccc(Br)cc2)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
118727188 | 117456 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 542 | 8 | 0 | 4 | 5.0 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(F)cc3)C[C@H]2C)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
CHEMBL3397999 | 117456 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 542 | 8 | 0 | 4 | 5.0 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(F)cc3)C[C@H]2C)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
44194675 | 10834 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 651 | 11 | 2 | 6 | 3.6 | C=CCN(C(=O)NCc1ccc(S(=O)(=O)N(C)C)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172053 | 10834 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 651 | 11 | 2 | 6 | 3.6 | C=CCN(C(=O)NCc1ccc(S(=O)(=O)N(C)C)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
50992574 | 57217 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 435 | 6 | 1 | 5 | 3.6 | CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C)CC3)C2)c1ccccc1 | 10.1021/jm100978n | |||
CHEMBL1649916 | 57217 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 435 | 6 | 1 | 5 | 3.6 | CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C)CC3)C2)c1ccccc1 | 10.1021/jm100978n | |||
46225528 | 202122 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 619 | 6 | 0 | 5 | 5.1 | Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL592993 | 202122 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 619 | 6 | 0 | 5 | 5.1 | Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
72714321 | 92735 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 610 | 8 | 1 | 5 | 5.6 | Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2cccc(Br)c2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435891 | 92735 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 610 | 8 | 1 | 5 | 5.6 | Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2cccc(Br)c2)CC1 | 10.1021/jm401101p | |||
3008902 | 205137 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -1 | 2 | ChEMBL | 512 | 6 | 0 | 4 | 5.1 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL61536 | 205137 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -1 | 2 | ChEMBL | 512 | 6 | 0 | 4 | 5.1 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
145985889 | 165488 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 498 | 8 | 1 | 7 | 3.7 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CC(=O)N(C)C1)c1cccs1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4238007 | 165488 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 498 | 8 | 1 | 7 | 3.7 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CC(=O)N(C)C1)c1cccs1 | 10.1021/acs.jmedchem.8b01077 | |||
59458213 | 92748 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 525 | 8 | 1 | 4 | 5.2 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C(C)C)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435904 | 92748 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 525 | 8 | 1 | 4 | 5.2 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C(C)C)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
49798131 | 10873 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 574 | 10 | 1 | 6 | 4.2 | C=CCN(C(=O)Cc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172439 | 10873 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 574 | 10 | 1 | 6 | 4.2 | C=CCN(C(=O)Cc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
3013575 | 75797 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 682 | 17 | 1 | 7 | 8.4 | CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc([S+]([O-])Cc4cncn4CCC)cc2)CCN3CC(C)C)cc1 | 10.1021/jm0509703 | |||
CHEMBL204821 | 75797 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 682 | 17 | 1 | 7 | 8.4 | CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc([S+]([O-])Cc4cncn4CCC)cc2)CCN3CC(C)C)cc1 | 10.1021/jm0509703 | |||
168273684 | 190499 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 553 | 8 | 1 | 6 | 6.7 | Cc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccsc1Cl | 10.1021/acs.jmedchem.2c01383 | |||
CHEMBL5177519 | 190499 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 553 | 8 | 1 | 6 | 6.7 | Cc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccsc1Cl | 10.1021/acs.jmedchem.2c01383 | |||
145984717 | 165629 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 511 | 8 | 1 | 6 | 5.8 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C(C)(C)C(F)(F)F)c1cccs1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4241284 | 165629 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 511 | 8 | 1 | 6 | 5.8 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C(C)(C)C(F)(F)F)c1cccs1 | 10.1021/acs.jmedchem.8b01077 | |||
3001322 | 443 | None | 22 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -123 | 4 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmcl.2010.12.109 | |||
805 | 443 | None | 22 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -123 | 4 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL1255794 | 443 | None | 22 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -123 | 4 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmcl.2010.12.109 | |||
DB06497 | 443 | None | 22 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -123 | 4 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmcl.2010.12.109 | |||
51039119 | 176321 | None | 34 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 1 | 3 | ChEMBL | 484 | 5 | 3 | 8 | 2.2 | CC(=O)N[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1N1CC[C@H](Nc2ncnc3cc(C(C)(C)C)nn23)C1=O | 10.1021/acsmedchemlett.1c00373 | |||
CHEMBL4594419 | 176321 | None | 34 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 1 | 3 | ChEMBL | 484 | 5 | 3 | 8 | 2.2 | CC(=O)N[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1N1CC[C@H](Nc2ncnc3cc(C(C)(C)C)nn23)C1=O | 10.1021/acsmedchemlett.1c00373 | |||
25024699 | 92691 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 558 | 5 | 0 | 5 | 5.4 | Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCC(N3C(=O)N(C4CCCCC4)C[C@H]3c3ccccc3)CC2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435847 | 92691 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 558 | 5 | 0 | 5 | 5.4 | Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCC(N3C(=O)N(C4CCCCC4)C[C@H]3c3ccccc3)CC2)CC1 | 10.1021/jm401101p | |||
72711047 | 92736 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 566 | 8 | 1 | 5 | 5.5 | Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2cccc(Cl)c2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435892 | 92736 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 566 | 8 | 1 | 5 | 5.5 | Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2cccc(Cl)c2)CC1 | 10.1021/jm401101p | |||
3001322 | 443 | None | 22 | Human | Functional | pIC50 | = | 8.2 | 8.2 | -123 | 4 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmc.2011.05.022 | |||
805 | 443 | None | 22 | Human | Functional | pIC50 | = | 8.2 | 8.2 | -123 | 4 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1255794 | 443 | None | 22 | Human | Functional | pIC50 | = | 8.2 | 8.2 | -123 | 4 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmc.2011.05.022 | |||
DB06497 | 443 | None | 22 | Human | Functional | pIC50 | = | 8.2 | 8.2 | -123 | 4 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmc.2011.05.022 | |||
5275762 | 77121 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 608 | 10 | 1 | 5 | 4.4 | CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(C(N)=O)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
CHEMBL207485 | 77121 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 608 | 10 | 1 | 5 | 4.4 | CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(C(N)=O)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
57402798 | 69221 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 540 | 10 | 1 | 5 | 6.1 | COc1ccc(N(Cc2ccccc2)C2CCN(C(C)CCNC(=O)c3c(Cl)cncc3Cl)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926873 | 69221 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 540 | 10 | 1 | 5 | 6.1 | COc1ccc(N(Cc2ccccc2)C2CCN(C(C)CCNC(=O)c3c(Cl)cncc3Cl)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
10208080 | 13068 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 481 | 10 | 1 | 4 | 4.7 | C=CCOc1ccc(CN2CCC3(CC2)C(=O)NC(CC2CCCCC2)C(=O)N3CCCC)cc1 | 10.1021/jm060051s | |||
CHEMBL1190106 | 13068 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 481 | 10 | 1 | 4 | 4.7 | C=CCOc1ccc(CN2CCC3(CC2)C(=O)NC(CC2CCCCC2)C(=O)N3CCCC)cc1 | 10.1021/jm060051s | |||
CHEMBL540108 | 13068 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 481 | 10 | 1 | 4 | 4.7 | C=CCOc1ccc(CN2CCC3(CC2)C(=O)NC(CC2CCCCC2)C(=O)N3CCCC)cc1 | 10.1021/jm060051s | |||
10228759 | 14352 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 463 | 9 | 1 | 4 | 4.7 | CCCCN1C(=O)C(CCC)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1171291 | 14352 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 463 | 9 | 1 | 4 | 4.7 | CCCCN1C(=O)C(CCC)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1200080 | 14352 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 463 | 9 | 1 | 4 | 4.7 | CCCCN1C(=O)C(CCC)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
3500 | 1526 | None | 13 | Human | Functional | pIC50 | = | 7.3 | 7.3 | 245 | 2 | ChEMBL | 483 | 7 | 1 | 5 | 3.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C21CCN(CC2)Cc1ccc2c(c1)OCCO2 | 10.1016/j.bmcl.2009.11.018 | |||
491774 | 1526 | None | 13 | Human | Functional | pIC50 | = | 7.3 | 7.3 | 245 | 2 | ChEMBL | 483 | 7 | 1 | 5 | 3.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C21CCN(CC2)Cc1ccc2c(c1)OCCO2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL1196395 | 1526 | None | 13 | Human | Functional | pIC50 | = | 7.3 | 7.3 | 245 | 2 | ChEMBL | 483 | 7 | 1 | 5 | 3.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C21CCN(CC2)Cc1ccc2c(c1)OCCO2 | 10.1016/j.bmcl.2009.11.018 | |||
10228761 | 13934 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 463 | 8 | 1 | 4 | 4.6 | CCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1021/jm060051s | |||
CHEMBL1196469 | 13934 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 463 | 8 | 1 | 4 | 4.6 | CCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1021/jm060051s | |||
CHEMBL557150 | 13934 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 463 | 8 | 1 | 4 | 4.6 | CCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1021/jm060051s | |||
10228761 | 13934 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 463 | 8 | 1 | 4 | 4.6 | CCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1196469 | 13934 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 463 | 8 | 1 | 4 | 4.6 | CCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL557150 | 13934 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 463 | 8 | 1 | 4 | 4.6 | CCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
56664935 | 66412 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 535 | 7 | 3 | 6 | 3.4 | CN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813444 | 66412 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 535 | 7 | 3 | 6 | 3.4 | CN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851773 | 66412 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 535 | 7 | 3 | 6 | 3.4 | CN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
6320546 | 60143 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL1668022 | 60143 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL1739500 | 60143 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
122668161 | 165700 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 491 | 8 | 1 | 6 | 5.8 | Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)c2ccccc2)s1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4242946 | 165700 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 491 | 8 | 1 | 6 | 5.8 | Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)c2ccccc2)s1 | 10.1021/acs.jmedchem.8b01077 | |||
90656341 | 111192 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 477 | 8 | 1 | 7 | 4.6 | CSc1ccc(CN2CCN(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 | 10.1016/j.bmcl.2014.03.073 | |||
CHEMBL3263320 | 111192 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 477 | 8 | 1 | 7 | 4.6 | CSc1ccc(CN2CCN(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 | 10.1016/j.bmcl.2014.03.073 | |||
6320546 | 60143 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1668022 | 60143 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1739500 | 60143 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
3008919 | 100819 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 453 | 5 | 0 | 3 | 6.0 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2ccccc2)CC1 | 10.1021/jm031046g | |||
CHEMBL292894 | 100819 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 453 | 5 | 0 | 3 | 6.0 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2ccccc2)CC1 | 10.1021/jm031046g | |||
73351060 | 92850 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 487 | 10 | 1 | 6 | 5.4 | CCOc1ccc(C2CCN(Cc3ccc(N(CC)CC)cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.ejmech.2013.09.004 | |||
CHEMBL2436822 | 92850 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 487 | 10 | 1 | 6 | 5.4 | CCOc1ccc(C2CCN(Cc3ccc(N(CC)CC)cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.ejmech.2013.09.004 | |||
52941008 | 19077 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 772 | 12 | 1 | 5 | 7.1 | C=CCN(C(=O)Cc1ccc(F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288918 | 19077 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 772 | 12 | 1 | 5 | 7.1 | C=CCN(C(=O)Cc1ccc(F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
21926948 | 14328 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 503 | 9 | 1 | 4 | 5.5 | CCCCN1C(=O)C(CC2CCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1170694 | 14328 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 503 | 9 | 1 | 4 | 5.5 | CCCCN1C(=O)C(CC2CCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1199991 | 14328 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 503 | 9 | 1 | 4 | 5.5 | CCCCN1C(=O)C(CC2CCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
56681915 | 66438 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 591 | 10 | 3 | 6 | 5.0 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813440 | 66438 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 591 | 10 | 3 | 6 | 5.0 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851889 | 66438 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 591 | 10 | 3 | 6 | 5.0 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
57331305 | 104650 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 566 | 10 | 0 | 4 | 5.1 | CCN(Cc1ccccc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
CHEMBL3104695 | 104650 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 566 | 10 | 0 | 4 | 5.1 | CCN(Cc1ccccc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
52941648 | 19076 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 822 | 12 | 1 | 5 | 8.0 | C=CCN(C(=O)Cc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288917 | 19076 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 822 | 12 | 1 | 5 | 8.0 | C=CCN(C(=O)Cc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
16728787 | 12847 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 533 | 9 | 2 | 5 | 4.9 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
CHEMBL1188566 | 12847 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 533 | 9 | 2 | 5 | 4.9 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
CHEMBL536754 | 12847 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 533 | 9 | 2 | 5 | 4.9 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
16728787 | 12847 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 533 | 9 | 2 | 5 | 4.9 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL1188566 | 12847 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 533 | 9 | 2 | 5 | 4.9 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL536754 | 12847 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 533 | 9 | 2 | 5 | 4.9 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
46225531 | 202629 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 522 | 6 | 0 | 4 | 3.9 | Cc1ccnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL596523 | 202629 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 522 | 6 | 0 | 4 | 3.9 | Cc1ccnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
21927225 | 14346 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 473 | 7 | 1 | 4 | 4.2 | CC#CCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1171096 | 14346 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 473 | 7 | 1 | 4 | 4.2 | CC#CCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1200061 | 14346 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 473 | 7 | 1 | 4 | 4.2 | CC#CCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
6479877 | 12517 | None | 2 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL1186558 | 12517 | None | 2 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL2057533 | 12517 | None | 2 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL469649 | 12517 | None | 2 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2012.05.127 | |||
6479877 | 12517 | None | 2 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL1186558 | 12517 | None | 2 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL2057533 | 12517 | None | 2 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL469649 | 12517 | None | 2 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
162660784 | 181374 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | -25 | 2 | ChEMBL | 1225 | 30 | 7 | 15 | 7.3 | Cc1nnc(C(C)C)n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(=O)NCCCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)cc1 | 10.1016/j.bmc.2016.09.059 | |||
CHEMBL4761986 | 181374 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | -25 | 2 | ChEMBL | 1225 | 30 | 7 | 15 | 7.3 | Cc1nnc(C(C)C)n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(=O)NCCCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)cc1 | 10.1016/j.bmc.2016.09.059 | |||
6479877 | 12517 | None | 2 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL1186558 | 12517 | None | 2 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL2057533 | 12517 | None | 2 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL469649 | 12517 | None | 2 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2011.07.058 | |||
46225395 | 203750 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 503 | 6 | 0 | 6 | 2.3 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCOC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL604070 | 203750 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 503 | 6 | 0 | 6 | 2.3 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCOC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL5078769 | 217072 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(C(C)=O)CC3)c3ccc(C)c(Cl)c3)CC2)cc1)C(N)=O | 10.1021/acs.jmedchem.1c00781 | |||||
9978318 | 122419 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 400 | 8 | 1 | 7 | 2.1 | COc1ccc(/C=C/C(=O)OC(C)C(=O)[C@H]2C[C@@H]2[C@H](O)[C@H]2CC=CC(=O)O2)cc1 | 10.1016/j.bmcl.2004.08.021 | |||
CHEMBL359986 | 122419 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 400 | 8 | 1 | 7 | 2.1 | COc1ccc(/C=C/C(=O)OC(C)C(=O)[C@H]2C[C@@H]2[C@H](O)[C@H]2CC=CC(=O)O2)cc1 | 10.1016/j.bmcl.2004.08.021 | |||
46225395 | 203750 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 503 | 6 | 0 | 6 | 2.3 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCOC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL604070 | 203750 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 503 | 6 | 0 | 6 | 2.3 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCOC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
46225513 | 203866 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 505 | 7 | 1 | 6 | 2.3 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C(C)(C)CO)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL604680 | 203866 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | - | 1 | ChEMBL | 505 | 7 | 1 | 6 | 2.3 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C(C)(C)CO)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
3001322 | 443 | None | 22 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -123 | 4 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmc.2011.05.022 | |||
805 | 443 | None | 22 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -123 | 4 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1255794 | 443 | None | 22 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -123 | 4 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmc.2011.05.022 | |||
DB06497 | 443 | None | 22 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -123 | 4 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmc.2011.05.022 | |||
73349506 | 92843 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 473 | 9 | 1 | 6 | 5.0 | CCN(CC)c1ccc(CN2CCC(c3ccc(OC)c(NC(=O)c4cnccn4)c3)CC2)cc1 | 10.1016/j.ejmech.2013.09.004 | |||
CHEMBL2436814 | 92843 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 473 | 9 | 1 | 6 | 5.0 | CCN(CC)c1ccc(CN2CCC(c3ccc(OC)c(NC(=O)c4cnccn4)c3)CC2)cc1 | 10.1016/j.ejmech.2013.09.004 | |||
49799707 | 14332 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 544 | 9 | 2 | 4 | 5.4 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(C(=O)Nc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1170873 | 14332 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 544 | 9 | 2 | 4 | 5.4 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(C(=O)Nc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1200014 | 14332 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 544 | 9 | 2 | 4 | 5.4 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(C(=O)Nc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL5074744 | 216817 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | -1 | 3 | ChEMBL | None | None | None | CC(C)c1nnc(CCNC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)n1C1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1 | 10.1021/acs.jmedchem.1c00408 | |||||
21925890 | 14381 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 508 | 8 | 1 | 5 | 5.2 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1csc(-c3ccccc3)n1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1172870 | 14381 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 508 | 8 | 1 | 5 | 5.2 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1csc(-c3ccccc3)n1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1200223 | 14381 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 508 | 8 | 1 | 5 | 5.2 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1csc(-c3ccccc3)n1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
3008921 | 168335 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 459 | 5 | 0 | 3 | 6.3 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)C2CCCCC2)CC1 | 10.1021/jm031046g | |||
CHEMBL433635 | 168335 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 459 | 5 | 0 | 3 | 6.3 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)C2CCCCC2)CC1 | 10.1021/jm031046g | |||
46225344 | 202525 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 535 | 5 | 0 | 5 | 4.2 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)(C)C)CC3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL595760 | 202525 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 535 | 5 | 0 | 5 | 4.2 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)(C)C)CC3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
21927257 | 14327 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 569 | 11 | 1 | 6 | 5.1 | CCCCN1C(=O)C(CC(=O)OCc2ccccc2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1170660 | 14327 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 569 | 11 | 1 | 6 | 5.1 | CCCCN1C(=O)C(CC(=O)OCc2ccccc2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1199989 | 14327 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 569 | 11 | 1 | 6 | 5.1 | CCCCN1C(=O)C(CC(=O)OCc2ccccc2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
73352534 | 92846 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 459 | 7 | 2 | 6 | 4.1 | COc1ccc(C2CCN(Cc3ccc(NC(C)=O)cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.ejmech.2013.09.004 | |||
CHEMBL2436817 | 92846 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 459 | 7 | 2 | 6 | 4.1 | COc1ccc(C2CCN(Cc3ccc(NC(C)=O)cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.ejmech.2013.09.004 | |||
56657984 | 66409 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 548 | 7 | 3 | 6 | 3.1 | CNC(=O)c1ccc(Oc2ccc(CN3CCC4(CC3)C(=O)N[C@H]([C@H](O)C3CCCCC3)C(=O)N4C)cc2)cc1 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813445 | 66409 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 548 | 7 | 3 | 6 | 3.1 | CNC(=O)c1ccc(Oc2ccc(CN3CCC4(CC3)C(=O)N[C@H]([C@H](O)C3CCCCC3)C(=O)N4C)cc2)cc1 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851766 | 66409 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 548 | 7 | 3 | 6 | 3.1 | CNC(=O)c1ccc(Oc2ccc(CN3CCC4(CC3)C(=O)N[C@H]([C@H](O)C3CCCCC3)C(=O)N4C)cc2)cc1 | 10.1016/j.bmc.2011.05.022 | |||
72714320 | 92734 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 546 | 8 | 1 | 5 | 5.2 | Cc1cccc(C2CN(C3CCCCC3)C(=O)N2C2CCN(C(C)CCNC(=O)c3c(C)ncnc3C)CC2)c1 | 10.1021/jm401101p | |||
CHEMBL2435890 | 92734 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 546 | 8 | 1 | 5 | 5.2 | Cc1cccc(C2CN(C3CCCCC3)C(=O)N2C2CCN(C(C)CCNC(=O)c3c(C)ncnc3C)CC2)c1 | 10.1021/jm401101p | |||
49798080 | 10820 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 629 | 10 | 1 | 6 | 5.7 | C=CCN(C(=O)OCc1ccc(OC(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172039 | 10820 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 629 | 10 | 1 | 6 | 5.7 | C=CCN(C(=O)OCc1ccc(OC(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
49798088 | 10830 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 628 | 10 | 2 | 5 | 5.3 | C=CCN(C(=O)NCc1ccc(OC(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172049 | 10830 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 628 | 10 | 2 | 5 | 5.3 | C=CCN(C(=O)NCc1ccc(OC(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
3008914 | 203466 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 573 | 6 | 0 | 3 | 7.2 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccc(Br)cc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL60225 | 203466 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 573 | 6 | 0 | 3 | 7.2 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccc(Br)cc3)CC2)CC1 | 10.1021/jm031046g | |||
16728325 | 10818 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 575 | 10 | 1 | 6 | 4.8 | C=CCN(C(=O)OCc1ccc(OC)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1172036 | 10818 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 575 | 10 | 1 | 6 | 4.8 | C=CCN(C(=O)OCc1ccc(OC)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
59458159 | 92752 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 567 | 8 | 1 | 5 | 5.0 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435908 | 92752 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 567 | 8 | 1 | 5 | 5.0 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
56647076 | 92725 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 553 | 8 | 1 | 4 | 7.0 | O=C(O)c1ccc(Oc2ccc(CN3CCC(N4C(=O)N(C5CCCCC5)C[C@H]4c4ccccc4)CC3)cc2)cc1 | 10.1021/jm401101p | |||
CHEMBL2435881 | 92725 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 553 | 8 | 1 | 4 | 7.0 | O=C(O)c1ccc(Oc2ccc(CN3CCC(N4C(=O)N(C5CCCCC5)C[C@H]4c4ccccc4)CC3)cc2)cc1 | 10.1021/jm401101p | |||
11692945 | 76560 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 608 | 10 | 1 | 5 | 4.4 | CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccccc3C(N)=O)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
CHEMBL206088 | 76560 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 608 | 10 | 1 | 5 | 4.4 | CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccccc3C(N)=O)CC2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm051034q | |||
118727174 | 117442 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 542 | 8 | 0 | 4 | 5.0 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
CHEMBL3397985 | 117442 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 542 | 8 | 0 | 4 | 5.0 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
49864974 | 15793 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 656 | 9 | 2 | 4 | 6.1 | C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)[C@@H]1C[C@@H]2CC[C@H](C1)N2C[C@H]1CN(C(=O)C2CCCC2)C[C@]1(O)c1cccc(F)c1 | 10.1016/j.bmcl.2010.05.046 | |||
CHEMBL1222772 | 15793 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 656 | 9 | 2 | 4 | 6.1 | C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)[C@@H]1C[C@@H]2CC[C@H](C1)N2C[C@H]1CN(C(=O)C2CCCC2)C[C@]1(O)c1cccc(F)c1 | 10.1016/j.bmcl.2010.05.046 | |||
126567286 | 165472 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 533 | 8 | 1 | 6 | 6.3 | Cc1csc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)c1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4237581 | 165472 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 533 | 8 | 1 | 6 | 6.3 | Cc1csc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)c1 | 10.1021/acs.jmedchem.8b01077 | |||
145986277 | 165994 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 549 | 9 | 1 | 7 | 6.0 | COc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)s1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4249941 | 165994 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 549 | 9 | 1 | 7 | 6.0 | COc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)s1 | 10.1021/acs.jmedchem.8b01077 | |||
56647023 | 92724 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 552 | 8 | 1 | 4 | 6.4 | NC(=O)c1ccc(Oc2ccc(CN3CCC(N4C(=O)N(C5CCCCC5)C[C@H]4c4ccccc4)CC3)cc2)cc1 | 10.1021/jm401101p | |||
CHEMBL2435880 | 92724 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 552 | 8 | 1 | 4 | 6.4 | NC(=O)c1ccc(Oc2ccc(CN3CCC(N4C(=O)N(C5CCCCC5)C[C@H]4c4ccccc4)CC3)cc2)cc1 | 10.1021/jm401101p | |||
52944587 | 19067 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 837 | 12 | 2 | 5 | 8.1 | C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288880 | 19067 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 837 | 12 | 2 | 5 | 8.1 | C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
52944617 | 19075 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 813 | 12 | 2 | 7 | 7.4 | C=CCN(C(=O)Nc1ccc(OC(C)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288916 | 19075 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 813 | 12 | 2 | 7 | 7.4 | C=CCN(C(=O)Nc1ccc(OC(C)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
46225531 | 202629 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 522 | 6 | 0 | 4 | 3.9 | Cc1ccnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL596523 | 202629 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 522 | 6 | 0 | 4 | 3.9 | Cc1ccnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
44395386 | 127605 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 400 | 8 | 1 | 7 | 2.1 | COc1ccc(/C=C\C(=O)OC(C)C(=O)[C@H]2C[C@@H]2[C@H](O)[C@H]2CC=CC(=O)O2)cc1 | 10.1016/j.bmcl.2004.08.021 | |||
CHEMBL366260 | 127605 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 400 | 8 | 1 | 7 | 2.1 | COc1ccc(/C=C\C(=O)OC(C)C(=O)[C@H]2C[C@@H]2[C@H](O)[C@H]2CC=CC(=O)O2)cc1 | 10.1016/j.bmcl.2004.08.021 | |||
3008934 | 201149 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 467 | 5 | 0 | 3 | 6.2 | Cc1cccc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL58101 | 201149 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 467 | 5 | 0 | 3 | 6.2 | Cc1cccc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
73352529 | 92823 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCN(CC)c1ccc(CN2CCC(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 | 10.1016/j.ejmech.2013.09.004 | |||
CHEMBL2436715 | 92823 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCN(CC)c1ccc(CN2CCC(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 | 10.1016/j.ejmech.2013.09.004 | |||
73346461 | 92851 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 461 | 8 | 1 | 7 | 4.4 | CCOc1ccc(C2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.ejmech.2013.09.004 | |||
CHEMBL2436823 | 92851 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 461 | 8 | 1 | 7 | 4.4 | CCOc1ccc(C2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.ejmech.2013.09.004 | |||
3008937 | 202556 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 469 | 5 | 0 | 5 | 5.0 | Cc1ncnc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL59602 | 202556 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 469 | 5 | 0 | 5 | 5.0 | Cc1ncnc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
90666577 | 109454 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 886 | 25 | 5 | 11 | 4.9 | CNC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)Nc1ccc([C@H](CCN2C3CCC2CC(n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)cc1 | 10.1039/c3md00080j | |||
CHEMBL3219779 | 109454 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 886 | 25 | 5 | 11 | 4.9 | CNC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)Nc1ccc([C@H](CCN2C3CCC2CC(n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)cc1 | 10.1039/c3md00080j | |||
101577042 | 183248 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 886 | 25 | 5 | 11 | 4.9 | CNC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)Nc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)cc1 | 10.1016/j.bmc.2016.09.059 | |||
CHEMBL4795179 | 183248 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 886 | 25 | 5 | 11 | 4.9 | CNC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)Nc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)cc1 | 10.1016/j.bmc.2016.09.059 | |||
112500047 | 124537 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 643 | 13 | 3 | 8 | 4.4 | Cc1nnc(C(C)C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(N)=O)cc1 | nan | |||
CHEMBL3639964 | 124537 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 643 | 13 | 3 | 8 | 4.4 | Cc1nnc(C(C)C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(N)=O)cc1 | nan | |||
118727192 | 117460 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 430 | 7 | 1 | 4 | 4.5 | N#Cc1ccc(N2CCN(CCC(NC(=O)C3CCCCC3)c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2014.12.052 | |||
CHEMBL3398003 | 117460 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 430 | 7 | 1 | 4 | 4.5 | N#Cc1ccc(N2CCN(CCC(NC(=O)C3CCCCC3)c3ccccc3)CC2)cc1 | 10.1016/j.bmc.2014.12.052 | |||
90656330 | 111131 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 465 | 7 | 1 | 6 | 4.5 | CC(C)Oc1ccc(N2CCN(Cc3ccc(Cl)cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.bmcl.2014.03.073 | |||
CHEMBL3263026 | 111131 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 465 | 7 | 1 | 6 | 4.5 | CC(C)Oc1ccc(N2CCN(Cc3ccc(Cl)cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.bmcl.2014.03.073 | |||
49798349 | 10795 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 471 | 6 | 2 | 4 | 5.9 | O=C(O)c1ccccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
CHEMBL1171786 | 10795 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 471 | 6 | 2 | 4 | 5.9 | O=C(O)c1ccccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2010.04.142 | |||
73347961 | 92849 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 429 | 7 | 2 | 4 | 5.3 | CCOc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1ccccc1 | 10.1016/j.ejmech.2013.09.004 | |||
CHEMBL2436820 | 92849 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 429 | 7 | 2 | 4 | 5.3 | CCOc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1ccccc1 | 10.1016/j.ejmech.2013.09.004 | |||
73347961 | 92849 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 429 | 7 | 2 | 4 | 5.3 | CCOc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1ccccc1 | 10.1016/j.bmcl.2014.03.073 | |||
CHEMBL2436820 | 92849 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 429 | 7 | 2 | 4 | 5.3 | CCOc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1ccccc1 | 10.1016/j.bmcl.2014.03.073 | |||
10416 | 1879 | None | 31 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -309 | 3 | ChEMBL | 548 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl | 10.1021/jm301572h | |||
46861584 | 1879 | None | 31 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -309 | 3 | ChEMBL | 548 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl | 10.1021/jm301572h | |||
CHEMBL2018969 | 1879 | None | 31 | Human | Functional | pIC50 | = | 5.2 | 5.2 | -309 | 3 | ChEMBL | 548 | 9 | 3 | 8 | 4.0 | COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl | 10.1021/jm301572h | |||
52947064 | 19066 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 823 | 11 | 2 | 5 | 8.5 | C=CCN(C(=O)Nc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288879 | 19066 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 823 | 11 | 2 | 5 | 8.5 | C=CCN(C(=O)Nc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
10278617 | 95235 | None | 3 | Crab-eating macaque | Functional | pIC50 | = | 7.2 | 7.2 | -1 | 2 | ChEMBL | 499 | 5 | 0 | 5 | 4.6 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1 | 10.1016/j.bmcl.2008.01.108 | |||
CHEMBL255858 | 95235 | None | 3 | Crab-eating macaque | Functional | pIC50 | = | 7.2 | 7.2 | -1 | 2 | ChEMBL | 499 | 5 | 0 | 5 | 4.6 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1 | 10.1016/j.bmcl.2008.01.108 | |||
57331304 | 104638 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 552 | 9 | 0 | 4 | 4.7 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)N(C)Cc3ccccc3)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
CHEMBL3104681 | 104638 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 552 | 9 | 0 | 4 | 4.7 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)N(C)Cc3ccccc3)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
73357100 | 92847 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 485 | 10 | 1 | 4 | 6.6 | CCOc1ccc(C2CCN(Cc3ccc(N(CC)CC)cc3)CC2)cc1NC(=O)c1ccccc1 | 10.1016/j.ejmech.2013.09.004 | |||
CHEMBL2436818 | 92847 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 485 | 10 | 1 | 4 | 6.6 | CCOc1ccc(C2CCN(Cc3ccc(N(CC)CC)cc3)CC2)cc1NC(=O)c1ccccc1 | 10.1016/j.ejmech.2013.09.004 | |||
90656326 | 111128 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 476 | 8 | 1 | 8 | 3.7 | CC(C)Oc1ccc(N2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.bmcl.2014.03.073 | |||
CHEMBL3263022 | 111128 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 476 | 8 | 1 | 8 | 3.7 | CC(C)Oc1ccc(N2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.bmcl.2014.03.073 | |||
52949553 | 19078 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 832 | 13 | 1 | 7 | 6.4 | C=CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288919 | 19078 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 832 | 13 | 1 | 7 | 6.4 | C=CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
46225394 | 202566 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 501 | 6 | 0 | 5 | 3.5 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCCC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL596081 | 202566 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 501 | 6 | 0 | 5 | 3.5 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCCC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
16658856 | 66498 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL1817909 | 66498 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL1852220 | 66498 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL2057810 | 66498 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2012.05.127 | |||
16658856 | 66498 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL1817909 | 66498 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL1852220 | 66498 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL2057810 | 66498 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
16658856 | 66498 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL1817909 | 66498 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL1852220 | 66498 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL2057810 | 66498 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2011.07.058 | |||
73349499 | 92824 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 475 | 8 | 1 | 7 | 4.8 | CC(C)Oc1ccc(C2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.ejmech.2013.09.004 | |||
CHEMBL2436716 | 92824 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 475 | 8 | 1 | 7 | 4.8 | CC(C)Oc1ccc(C2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.ejmech.2013.09.004 | |||
46225529 | 202151 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 591 | 6 | 0 | 5 | 4.3 | Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL593195 | 202151 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 591 | 6 | 0 | 5 | 4.3 | Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
145961982 | 161626 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | -10 | 2 | ChEMBL | 553 | 8 | 1 | 6 | 4.3 | CN(C1CCN(CCCN2CCCc3c(ccnc3Nc3ccc(Cl)c(Cl)c3)C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
CHEMBL4128498 | 161626 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | -10 | 2 | ChEMBL | 553 | 8 | 1 | 6 | 4.3 | CN(C1CCN(CCCN2CCCc3c(ccnc3Nc3ccc(Cl)c(Cl)c3)C2=O)CC1)S(C)(=O)=O | 10.1016/j.bmc.2018.05.027 | |||
56661524 | 66452 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 549 | 10 | 3 | 6 | 3.8 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813438 | 66452 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 549 | 10 | 3 | 6 | 3.8 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851951 | 66452 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 549 | 10 | 3 | 6 | 3.8 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
73354018 | 92821 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 443 | 7 | 2 | 4 | 5.7 | CC(C)Oc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1ccccc1 | 10.1016/j.ejmech.2013.09.004 | |||
CHEMBL2436713 | 92821 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 443 | 7 | 2 | 4 | 5.7 | CC(C)Oc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1ccccc1 | 10.1016/j.ejmech.2013.09.004 | |||
46225394 | 202566 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 501 | 6 | 0 | 5 | 3.5 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCCC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL596081 | 202566 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 501 | 6 | 0 | 5 | 3.5 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCCC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
3008918 | 201840 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 467 | 5 | 0 | 3 | 6.3 | Cc1ccccc1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL59101 | 201840 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 467 | 5 | 0 | 3 | 6.3 | Cc1ccccc1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
126567281 | 165605 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 520 | 8 | 1 | 7 | 5.4 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cscn1 | 10.1021/acs.jmedchem.2c01383 | |||
CHEMBL4240742 | 165605 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 520 | 8 | 1 | 7 | 5.4 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cscn1 | 10.1021/acs.jmedchem.2c01383 | |||
122185625 | 122973 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 504 | 8 | 2 | 6 | 3.2 | Cc1c(CNC(=O)c2ccc([N+](=O)[O-])cc2)c(C)[n+]2c(c1CNC(=O)c1ccc([N+](=O)[O-])cc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3604304 | 122973 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 504 | 8 | 2 | 6 | 3.2 | Cc1c(CNC(=O)c2ccc([N+](=O)[O-])cc2)c(C)[n+]2c(c1CNC(=O)c1ccc([N+](=O)[O-])cc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3606026 | 122973 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 504 | 8 | 2 | 6 | 3.2 | Cc1c(CNC(=O)c2ccc([N+](=O)[O-])cc2)c(C)[n+]2c(c1CNC(=O)c1ccc([N+](=O)[O-])cc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
168284187 | 190964 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 519 | 7 | 1 | 6 | 5.9 | Cc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C(F)(F)F)c1csc2ccccc12 | 10.1021/acs.jmedchem.2c01383 | |||
CHEMBL5184527 | 190964 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 519 | 7 | 1 | 6 | 5.9 | Cc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C(F)(F)F)c1csc2ccccc12 | 10.1021/acs.jmedchem.2c01383 | |||
23577370 | 66385 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 549 | 9 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813270 | 66385 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 549 | 9 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851623 | 66385 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 549 | 9 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
56681917 | 66457 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 604 | 11 | 3 | 6 | 4.6 | CCCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813450 | 66457 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 604 | 11 | 3 | 6 | 4.6 | CCCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851972 | 66457 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 604 | 11 | 3 | 6 | 4.6 | CCCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
46225429 | 202541 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 527 | 5 | 0 | 5 | 4.2 | Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C(C)(C)C)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL595902 | 202541 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 527 | 5 | 0 | 5 | 4.2 | Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C(C)(C)C)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
21926618 | 14345 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 475 | 8 | 1 | 4 | 4.8 | C/C=C/CN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1171095 | 14345 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 475 | 8 | 1 | 4 | 4.8 | C/C=C/CN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1200060 | 14345 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 475 | 8 | 1 | 4 | 4.8 | C/C=C/CN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
122185635 | 122985 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 474 | 8 | 2 | 4 | 3.4 | COc1ccc(C(=O)NCc2c(C)c(CNC(=O)c3ccc(OC)cc3)c3[n+](c2C)CCC3)cc1 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3604309 | 122985 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 474 | 8 | 2 | 4 | 3.4 | COc1ccc(C(=O)NCc2c(C)c(CNC(=O)c3ccc(OC)cc3)c3[n+](c2C)CCC3)cc1 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3606103 | 122985 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 474 | 8 | 2 | 4 | 3.4 | COc1ccc(C(=O)NCc2c(C)c(CNC(=O)c3ccc(OC)cc3)c3[n+](c2C)CCC3)cc1 | 10.1016/j.bmcl.2015.06.029 | |||
44511966 | 69235 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 515 | 10 | 1 | 6 | 5.1 | COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cncc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926889 | 69235 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 515 | 10 | 1 | 6 | 5.1 | COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cncc3C)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
57394058 | 69251 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 510 | 9 | 1 | 6 | 5.0 | Cc1ccncc1CN(c1ccccc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(C#N)nc2C)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926905 | 69251 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 510 | 9 | 1 | 6 | 5.0 | Cc1ccncc1CN(c1ccccc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(C#N)nc2C)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
21867666 | 162153 | None | 52 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 112 | 0 | 2 | 2 | -0.6 | C1NCC2CNCC12 | 10.1016/j.ejmech.2018.01.085 | |||
CHEMBL4160473 | 162153 | None | 52 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 112 | 0 | 2 | 2 | -0.6 | C1NCC2CNCC12 | 10.1016/j.ejmech.2018.01.085 | |||
76313867 | 104649 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 566 | 10 | 0 | 4 | 4.9 | CCN(C(=O)Cc1ccccc1)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
CHEMBL3104694 | 104649 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 566 | 10 | 0 | 4 | 4.9 | CCN(C(=O)Cc1ccccc1)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
5275760 | 77092 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 623 | 10 | 0 | 6 | 5.1 | COC(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(S(C)(=O)=O)CC3)c3ccc(Cl)c(Cl)c3)CC2)cc1 | 10.1021/jm051034q | |||
CHEMBL207301 | 77092 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 623 | 10 | 0 | 6 | 5.1 | COC(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(S(C)(=O)=O)CC3)c3ccc(Cl)c(Cl)c3)CC2)cc1 | 10.1021/jm051034q | |||
72711278 | 92742 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 564 | 8 | 1 | 5 | 5.3 | Cc1cc(F)cc(C2CN(C3CCCCC3)C(=O)N2C2CCN(C(C)CCNC(=O)c3c(C)ncnc3C)CC2)c1 | 10.1021/jm401101p | |||
CHEMBL2435898 | 92742 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 564 | 8 | 1 | 5 | 5.3 | Cc1cc(F)cc(C2CN(C3CCCCC3)C(=O)N2C2CCN(C(C)CCNC(=O)c3c(C)ncnc3C)CC2)c1 | 10.1021/jm401101p | |||
3008935 | 205186 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 468 | 5 | 0 | 4 | 5.6 | Cc1ccnc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL61828 | 205186 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 468 | 5 | 0 | 4 | 5.6 | Cc1ccnc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
73346389 | 92723 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 580 | 8 | 0 | 4 | 7.0 | CN(C)C(=O)c1ccc(Oc2ccc(CN3CCC(N4C(=O)N(C5CCCCC5)C[C@H]4c4ccccc4)CC3)cc2)cc1 | 10.1021/jm401101p | |||
CHEMBL2435879 | 92723 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 580 | 8 | 0 | 4 | 7.0 | CN(C)C(=O)c1ccc(Oc2ccc(CN3CCC(N4C(=O)N(C5CCCCC5)C[C@H]4c4ccccc4)CC3)cc2)cc1 | 10.1021/jm401101p | |||
72711507 | 92747 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 525 | 9 | 1 | 4 | 5.2 | CCCN1C[C@@H](c2ccccc2)N(C2CCN(C(C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)C1=O | 10.1021/jm401101p | |||
CHEMBL2435903 | 92747 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 525 | 9 | 1 | 4 | 5.2 | CCCN1C[C@@H](c2ccccc2)N(C2CCN(C(C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)C1=O | 10.1021/jm401101p | |||
16728787 | 12847 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 533 | 9 | 2 | 5 | 4.9 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL1188566 | 12847 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 533 | 9 | 2 | 5 | 4.9 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL536754 | 12847 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 533 | 9 | 2 | 5 | 4.9 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
3008918 | 201840 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 467 | 5 | 0 | 3 | 6.3 | Cc1ccccc1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL59101 | 201840 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 467 | 5 | 0 | 3 | 6.3 | Cc1ccccc1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
183790 | 3742 | None | 8 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -2 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1016/j.bmcl.2011.07.058 | |||
783 | 3742 | None | 8 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -2 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL1178786 | 3742 | None | 8 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -2 | 5 | ChEMBL | 495 | 6 | 1 | 2 | 6.8 | Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C | 10.1016/j.bmcl.2011.07.058 | |||
3008932 | 205103 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 560 | 6 | 0 | 6 | 6.5 | Cc1nc(-c2ccncc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL61373 | 205103 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 560 | 6 | 0 | 6 | 6.5 | Cc1nc(-c2ccncc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
3008932 | 205103 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 560 | 6 | 0 | 6 | 6.5 | Cc1nc(-c2ccncc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL61373 | 205103 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 560 | 6 | 0 | 6 | 6.5 | Cc1nc(-c2ccncc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
3008923 | 201355 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 521 | 5 | 0 | 3 | 7.3 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2c(Cl)cccc2Cl)CC1 | 10.1021/jm031046g | |||
CHEMBL58441 | 201355 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 521 | 5 | 0 | 3 | 7.3 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2c(Cl)cccc2Cl)CC1 | 10.1021/jm031046g | |||
3008928 | 205114 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -1 | 2 | ChEMBL | 483 | 5 | 0 | 5 | 5.4 | Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL61424 | 205114 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -1 | 2 | ChEMBL | 483 | 5 | 0 | 5 | 5.4 | Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
168296928 | 192349 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 576 | 9 | 1 | 8 | 4.2 | Cc1ccc([C@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCN(S(C)(=O)=O)CC2)s1 | 10.1021/acs.jmedchem.2c01383 | |||
CHEMBL5205216 | 192349 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 576 | 9 | 1 | 8 | 4.2 | Cc1ccc([C@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCN(S(C)(=O)=O)CC2)s1 | 10.1021/acs.jmedchem.2c01383 | |||
72711051 | 92740 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 610 | 8 | 1 | 5 | 5.6 | Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccc(Br)cc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435896 | 92740 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 610 | 8 | 1 | 5 | 5.6 | Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccc(Br)cc2)CC1 | 10.1021/jm401101p | |||
73346454 | 92830 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 457 | 7 | 2 | 4 | 5.3 | COc1ccc(C2CCN(Cc3ccc(NC(C)=O)cc3)CC2)cc1NC(=O)c1ccccc1 | 10.1016/j.ejmech.2013.09.004 | |||
CHEMBL2436722 | 92830 | None | 0 | Human | Functional | pIC50 | = | 4.2 | 4.2 | - | 1 | ChEMBL | 457 | 7 | 2 | 4 | 5.3 | COc1ccc(C2CCN(Cc3ccc(NC(C)=O)cc3)CC2)cc1NC(=O)c1ccccc1 | 10.1016/j.ejmech.2013.09.004 | |||
49799680 | 14386 | None | 1 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 502 | 8 | 1 | 4 | 5.2 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(-c3cccnc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1200241 | 14386 | None | 1 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 502 | 8 | 1 | 4 | 5.2 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(-c3cccnc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL3217146 | 14386 | None | 1 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 502 | 8 | 1 | 4 | 5.2 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(-c3cccnc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
23577378 | 66453 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 563 | 10 | 2 | 6 | 4.9 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(OC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813269 | 66453 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 563 | 10 | 2 | 6 | 4.9 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(OC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851957 | 66453 | None | 0 | Human | Functional | pIC50 | = | 5.2 | 5.2 | - | 1 | ChEMBL | 563 | 10 | 2 | 6 | 4.9 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(OC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
3013673 | 76987 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 461 | 8 | 0 | 3 | 4.6 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccccc3)CC2)c2ccccc2)CC1 | 10.1021/jm051034q | |||
CHEMBL207085 | 76987 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 461 | 8 | 0 | 3 | 4.6 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccccc3)CC2)c2ccccc2)CC1 | 10.1021/jm051034q | |||
122668217 | 192375 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 454 | 8 | 1 | 7 | 4.4 | Cc1ccc([C@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)CC#N)s1 | 10.1021/acs.jmedchem.2c01383 | |||
CHEMBL5205626 | 192375 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 454 | 8 | 1 | 7 | 4.4 | Cc1ccc([C@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)CC#N)s1 | 10.1021/acs.jmedchem.2c01383 | |||
44395365 | 124540 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 386 | 7 | 2 | 7 | 1.8 | CC(OC(=O)/C=C/c1ccc(O)cc1)C(=O)[C@H]1C[C@@H]1[C@H](O)[C@H]1CC=CC(=O)O1 | 10.1016/j.bmcl.2004.08.021 | |||
CHEMBL363999 | 124540 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 386 | 7 | 2 | 7 | 1.8 | CC(OC(=O)/C=C/c1ccc(O)cc1)C(=O)[C@H]1C[C@@H]1[C@H](O)[C@H]1CC=CC(=O)O1 | 10.1016/j.bmcl.2004.08.021 | |||
73355552 | 92844 | None | 0 | Human | Functional | pIC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 447 | 7 | 1 | 7 | 4.0 | COc1ccc(C2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.ejmech.2013.09.004 | |||
CHEMBL2436815 | 92844 | None | 0 | Human | Functional | pIC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 447 | 7 | 1 | 7 | 4.0 | COc1ccc(C2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.ejmech.2013.09.004 | |||
23577382 | 66459 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 590 | 10 | 3 | 6 | 4.2 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813432 | 66459 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 590 | 10 | 3 | 6 | 4.2 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851977 | 66459 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 590 | 10 | 3 | 6 | 4.2 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
3008916 | 162455 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 509 | 7 | 0 | 3 | 6.5 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)Cc3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL416512 | 162455 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 509 | 7 | 0 | 3 | 6.5 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)Cc3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
57331339 | 104642 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 563 | 9 | 1 | 5 | 4.2 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCc3ccc(C#N)cc3)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
CHEMBL3104685 | 104642 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 563 | 9 | 1 | 5 | 4.2 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCc3ccc(C#N)cc3)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
57331275 | 104643 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 552 | 10 | 1 | 4 | 4.4 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCCc3ccccc3)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
CHEMBL3104688 | 104643 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 552 | 10 | 1 | 4 | 4.4 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCCc3ccccc3)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
10182763 | 13901 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 419 | 6 | 1 | 3 | 3.6 | CC(C)C[C@H]1NC(=O)C2(CCN(Cc3ccccc3)CC2)N(Cc2ccccc2)C1=O | 10.1021/jm060051s | |||
CHEMBL1196226 | 13901 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 419 | 6 | 1 | 3 | 3.6 | CC(C)C[C@H]1NC(=O)C2(CCN(Cc3ccccc3)CC2)N(Cc2ccccc2)C1=O | 10.1021/jm060051s | |||
CHEMBL556188 | 13901 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 419 | 6 | 1 | 3 | 3.6 | CC(C)C[C@H]1NC(=O)C2(CCN(Cc3ccccc3)CC2)N(Cc2ccccc2)C1=O | 10.1021/jm060051s | |||
73347956 | 92829 | None | 0 | Human | Functional | pIC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 415 | 6 | 2 | 4 | 4.9 | COc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1ccccc1 | 10.1016/j.ejmech.2013.09.004 | |||
CHEMBL2436721 | 92829 | None | 0 | Human | Functional | pIC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 415 | 6 | 2 | 4 | 4.9 | COc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1ccccc1 | 10.1016/j.ejmech.2013.09.004 | |||
73355549 | 92825 | None | 0 | Human | Functional | pIC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 445 | 7 | 2 | 6 | 4.5 | CC(C)Oc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.ejmech.2013.09.004 | |||
CHEMBL2436717 | 92825 | None | 0 | Human | Functional | pIC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 445 | 7 | 2 | 6 | 4.5 | CC(C)Oc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1cnccn1 | 10.1016/j.ejmech.2013.09.004 | |||
16728787 | 12847 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 533 | 9 | 2 | 5 | 4.9 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1188566 | 12847 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 533 | 9 | 2 | 5 | 4.9 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL536754 | 12847 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 533 | 9 | 2 | 5 | 4.9 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
56669616 | 66485 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 428 | 18 | 0 | 0 | 8.9 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL1817910 | 66485 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 428 | 18 | 0 | 0 | 8.9 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL1852129 | 66485 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 428 | 18 | 0 | 0 | 8.9 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL2057811 | 66485 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 428 | 18 | 0 | 0 | 8.9 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2012.05.127 | |||
56669616 | 66485 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 428 | 18 | 0 | 0 | 8.9 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL1817910 | 66485 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 428 | 18 | 0 | 0 | 8.9 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL1852129 | 66485 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 428 | 18 | 0 | 0 | 8.9 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL2057811 | 66485 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 428 | 18 | 0 | 0 | 8.9 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
56669616 | 66485 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 428 | 18 | 0 | 0 | 8.9 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL1817910 | 66485 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 428 | 18 | 0 | 0 | 8.9 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL1852129 | 66485 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 428 | 18 | 0 | 0 | 8.9 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL2057811 | 66485 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 428 | 18 | 0 | 0 | 8.9 | CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCC2 | 10.1016/j.bmcl.2011.07.058 | |||
16728784 | 12801 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 493 | 9 | 2 | 5 | 4.1 | CCCCN1C(=O)C(CC(C)(C)O)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
CHEMBL1188107 | 12801 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 493 | 9 | 2 | 5 | 4.1 | CCCCN1C(=O)C(CC(C)(C)O)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
CHEMBL535172 | 12801 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 493 | 9 | 2 | 5 | 4.1 | CCCCN1C(=O)C(CC(C)(C)O)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
21064126 | 14351 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 491 | 8 | 1 | 4 | 5.4 | CCCCN1C(=O)[C@H](CC(C)(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1171290 | 14351 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 491 | 8 | 1 | 4 | 5.4 | CCCCN1C(=O)[C@H](CC(C)(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1200079 | 14351 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 491 | 8 | 1 | 4 | 5.4 | CCCCN1C(=O)[C@H](CC(C)(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
21064297 | 14410 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 531 | 9 | 1 | 4 | 6.2 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C)cc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1173710 | 14410 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 531 | 9 | 1 | 4 | 6.2 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C)cc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1200301 | 14410 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 531 | 9 | 1 | 4 | 6.2 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C)cc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
46226124 | 14123 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 545 | 10 | 1 | 4 | 6.3 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(C)cc3)c1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL1198013 | 14123 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 545 | 10 | 1 | 4 | 6.3 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(C)cc3)c1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL593204 | 14123 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 545 | 10 | 1 | 4 | 6.3 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(C)cc3)c1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
90666580 | 109457 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 657 | 13 | 3 | 8 | 4.7 | CNC(=O)COCC(=O)Nc1ccc([C@H](CCN2C3CCC2CC(n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)cc1 | 10.1039/c3md00080j | |||
CHEMBL3219782 | 109457 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 657 | 13 | 3 | 8 | 4.7 | CNC(=O)COCC(=O)Nc1ccc([C@H](CCN2C3CCC2CC(n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)cc1 | 10.1039/c3md00080j | |||
57390535 | 69229 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 613 | 9 | 1 | 5 | 6.7 | CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2cccc(C#N)c2)c2ccc(Br)cc2)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926883 | 69229 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 613 | 9 | 1 | 5 | 6.7 | CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2cccc(C#N)c2)c2ccc(Br)cc2)CC1 | 10.1016/j.bmcl.2011.09.133 | |||
3002977 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.8b01077 | |||
3002977.0 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.8b01077 | |||
803 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.8b01077 | |||
806 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL1201187 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL256907 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL584744 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.8b01077 | |||
DB04835 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.8b01077 | |||
3002977 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.2c01383 | |||
3002977.0 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.2c01383 | |||
803 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.2c01383 | |||
806 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.2c01383 | |||
CHEMBL1201187 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.2c01383 | |||
CHEMBL256907 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.2c01383 | |||
CHEMBL584744 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.2c01383 | |||
DB04835 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 4 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.2c01383 | |||
145985237 | 165619 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 533 | 8 | 1 | 6 | 6.3 | Cc1cscc1[C@H](CCN1[C@H]2CC[C@@H]1C[C@@H](n1c(C)nnc1C(C)C)C2)NC(=O)C1CCC(F)(F)CC1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4241066 | 165619 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 533 | 8 | 1 | 6 | 6.3 | Cc1cscc1[C@H](CCN1[C@H]2CC[C@@H]1C[C@@H](n1c(C)nnc1C(C)C)C2)NC(=O)C1CCC(F)(F)CC1 | 10.1021/acs.jmedchem.8b01077 | |||
3008937 | 202556 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 469 | 5 | 0 | 5 | 5.0 | Cc1ncnc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL59602 | 202556 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 469 | 5 | 0 | 5 | 5.0 | Cc1ncnc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
5275764 | 76063 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 636 | 10 | 0 | 5 | 5.0 | CN(C)C(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(S(C)(=O)=O)CC3)c3ccc(Cl)c(Cl)c3)CC2)cc1 | 10.1021/jm051034q | |||
CHEMBL205706 | 76063 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 636 | 10 | 0 | 5 | 5.0 | CN(C)C(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(S(C)(=O)=O)CC3)c3ccc(Cl)c(Cl)c3)CC2)cc1 | 10.1021/jm051034q | |||
118727171 | 117439 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 549 | 8 | 0 | 5 | 4.7 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(C#N)cc3)CC2C)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
CHEMBL3397982 | 117439 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 549 | 8 | 0 | 5 | 4.7 | CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(C#N)cc3)CC2C)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
122668179 | 192606 | None | 2 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 601 | 8 | 1 | 6 | 6.0 | Cc1nc2c(n1[C@@H]1C[C@H]3CC[C@@H](C1)N3CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccsc1)CCN(C(=O)C(C)C)C2 | 10.1021/acs.jmedchem.2c01383 | |||
CHEMBL5209067 | 192606 | None | 2 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 601 | 8 | 1 | 6 | 6.0 | Cc1nc2c(n1[C@@H]1C[C@H]3CC[C@@H](C1)N3CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccsc1)CCN(C(=O)C(C)C)C2 | 10.1021/acs.jmedchem.2c01383 | |||
3008931 | 205104 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 559 | 6 | 0 | 5 | 7.1 | Cc1nc(-c2ccccc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL61374 | 205104 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 559 | 6 | 0 | 5 | 7.1 | Cc1nc(-c2ccccc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
52948264 | 19059 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 815 | 13 | 1 | 8 | 7.5 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288872 | 19059 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 815 | 13 | 1 | 8 | 7.5 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
16728324 | 10811 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 545 | 9 | 1 | 5 | 4.8 | C=CCN(C(=O)OCc1ccccc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
CHEMBL1171965 | 10811 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 545 | 9 | 1 | 5 | 4.8 | C=CCN(C(=O)OCc1ccccc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 | 10.1016/j.bmcl.2010.05.102 | |||
118727186 | 117454 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 540 | 8 | 0 | 4 | 4.7 | CC(=O)N1CCC(C(=O)N(CCCN2C[C@@H]3C[C@H]2CN3Cc2ccc(F)cc2)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
CHEMBL3397997 | 117454 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 540 | 8 | 0 | 4 | 4.7 | CC(=O)N1CCC(C(=O)N(CCCN2C[C@@H]3C[C@H]2CN3Cc2ccc(F)cc2)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
49864969 | 15788 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 608 | 10 | 1 | 7 | 4.9 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2010.05.046 | |||
CHEMBL1222767 | 15788 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 608 | 10 | 1 | 7 | 4.9 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2010.05.046 | |||
3008924 | 202159 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 503 | 5 | 0 | 3 | 7.1 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2cccc3ccccc23)CC1 | 10.1021/jm031046g | |||
CHEMBL59328 | 202159 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 503 | 5 | 0 | 3 | 7.1 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2cccc3ccccc23)CC1 | 10.1021/jm031046g | |||
3008903 | 163273 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 537 | 6 | 0 | 5 | 5.0 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3C#N)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL418120 | 163273 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 537 | 6 | 0 | 5 | 5.0 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3C#N)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
72712158 | 92709 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 609 | 9 | 2 | 5 | 5.4 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCC(C(=O)O)CC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435865 | 92709 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 609 | 9 | 2 | 5 | 5.4 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCC(C(=O)O)CC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
122185627 | 122983 | None | 0 | Human | Functional | pIC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 450 | 6 | 2 | 2 | 3.7 | Cc1c(CNC(=O)c2ccc(F)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(F)cc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3604305 | 122983 | None | 0 | Human | Functional | pIC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 450 | 6 | 2 | 2 | 3.7 | Cc1c(CNC(=O)c2ccc(F)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(F)cc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
CHEMBL3606099 | 122983 | None | 0 | Human | Functional | pIC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 450 | 6 | 2 | 2 | 3.7 | Cc1c(CNC(=O)c2ccc(F)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(F)cc1)CCC2 | 10.1016/j.bmcl.2015.06.029 | |||
49799705 | 14406 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 529 | 9 | 1 | 4 | 5.4 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(C(=O)c3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1173646 | 14406 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 529 | 9 | 1 | 4 | 5.4 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(C(=O)c3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1200294 | 14406 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 529 | 9 | 1 | 4 | 5.4 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(C(=O)c3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
56661522 | 66672 | None | 0 | Human | Functional | pIC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 535 | 10 | 3 | 6 | 3.4 | CCCCN1C(=O)[C@@H]([C@H](O)C2CC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813437 | 66672 | None | 0 | Human | Functional | pIC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 535 | 10 | 3 | 6 | 3.4 | CCCCN1C(=O)[C@@H]([C@H](O)C2CC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1852861 | 66672 | None | 0 | Human | Functional | pIC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 535 | 10 | 3 | 6 | 3.4 | CCCCN1C(=O)[C@@H]([C@H](O)C2CC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
126567273 | 165935 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 514 | 8 | 1 | 6 | 5.3 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cccnc1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4248733 | 165935 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 514 | 8 | 1 | 6 | 5.3 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cccnc1 | 10.1021/acs.jmedchem.8b01077 | |||
72711279 | 92743 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 533 | 8 | 1 | 6 | 4.3 | Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2cccnc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435899 | 92743 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 533 | 8 | 1 | 6 | 4.3 | Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2cccnc2)CC1 | 10.1021/jm401101p | |||
11569805 | 13930 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)[C@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
CHEMBL1196449 | 13930 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)[C@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
CHEMBL556995 | 13930 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)[C@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
16659334 | 14009 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 493 | 9 | 2 | 5 | 4.0 | CCCCN1C(=O)[C@@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL1197042 | 14009 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 493 | 9 | 2 | 5 | 4.0 | CCCCN1C(=O)[C@@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL559168 | 14009 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 493 | 9 | 2 | 5 | 4.0 | CCCCN1C(=O)[C@@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
11569805 | 13930 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)[C@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1196449 | 13930 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)[C@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL556995 | 13930 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)[C@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
56683103 | 66495 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 452 | 16 | 0 | 0 | 9.8 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL1817914 | 66495 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 452 | 16 | 0 | 0 | 9.8 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL1852172 | 66495 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 452 | 16 | 0 | 0 | 9.8 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL2057815 | 66495 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 452 | 16 | 0 | 0 | 9.8 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.bmcl.2012.05.127 | |||
56683103 | 66495 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 452 | 16 | 0 | 0 | 9.8 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL1817914 | 66495 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 452 | 16 | 0 | 0 | 9.8 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL1852172 | 66495 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 452 | 16 | 0 | 0 | 9.8 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL2057815 | 66495 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 452 | 16 | 0 | 0 | 9.8 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.ejmech.2012.07.049 | |||
56683103 | 66495 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 452 | 16 | 0 | 0 | 9.8 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL1817914 | 66495 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 452 | 16 | 0 | 0 | 9.8 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL1852172 | 66495 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 452 | 16 | 0 | 0 | 9.8 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.bmcl.2011.07.058 | |||
CHEMBL2057815 | 66495 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 452 | 16 | 0 | 0 | 9.8 | CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCCC2 | 10.1016/j.bmcl.2011.07.058 | |||
72713858 | 92754 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 538 | 8 | 1 | 6 | 4.9 | Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccsc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435910 | 92754 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 538 | 8 | 1 | 6 | 4.9 | Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccsc2)CC1 | 10.1021/jm401101p | |||
46225349 | 202506 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 539 | 6 | 0 | 5 | 4.3 | Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C4CCCC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL595610 | 202506 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 539 | 6 | 0 | 5 | 4.3 | Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C4CCCC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
491775 | 12882 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL1188807 | 12882 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL537424 | 12882 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
21064329 | 14344 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 565 | 9 | 1 | 5 | 5.0 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(S(=O)(=O)c3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1171069 | 14344 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 565 | 9 | 1 | 5 | 5.0 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(S(=O)(=O)c3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1200059 | 14344 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 565 | 9 | 1 | 5 | 5.0 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(S(=O)(=O)c3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
46226122 | 14118 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 579 | 10 | 1 | 5 | 5.0 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(S(=O)(=O)c3ccccc3)c1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL1198002 | 14118 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 579 | 10 | 1 | 5 | 5.0 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(S(=O)(=O)c3ccccc3)c1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL592918 | 14118 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 579 | 10 | 1 | 5 | 5.0 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(S(=O)(=O)c3ccccc3)c1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
76310164 | 104645 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 586 | 10 | 1 | 4 | 5.0 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCCc3ccc(Cl)cc3)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
CHEMBL3104690 | 104645 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 586 | 10 | 1 | 4 | 5.0 | CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCCc3ccc(Cl)cc3)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
52945865 | 19079 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 838 | 13 | 1 | 6 | 7.9 | C=CCN(C(=O)Cc1ccc(OC(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
CHEMBL1288920 | 19079 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 838 | 13 | 1 | 6 | 7.9 | C=CCN(C(=O)Cc1ccc(OC(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 | 10.1016/j.bmcl.2010.10.033 | |||
21064283 | 14337 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 561 | 10 | 2 | 5 | 5.6 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL1170878 | 14337 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 561 | 10 | 2 | 5 | 5.6 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL1200019 | 14337 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 561 | 10 | 2 | 5 | 5.6 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
145984103 | 165966 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 541 | 7 | 1 | 7 | 4.3 | CC(=O)N1CCN(C(=O)N[C@@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)c2ccc(C)s2)CC1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4249241 | 165966 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 541 | 7 | 1 | 7 | 4.3 | CC(=O)N1CCN(C(=O)N[C@@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)c2ccc(C)s2)CC1 | 10.1021/acs.jmedchem.8b01077 | |||
9978318 | 122419 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 400 | 8 | 1 | 7 | 2.1 | COc1ccc(/C=C/C(=O)OC(C)C(=O)[C@H]2C[C@@H]2[C@H](O)[C@H]2CC=CC(=O)O2)cc1 | 10.1016/j.bmcl.2004.08.021 | |||
CHEMBL359986 | 122419 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 400 | 8 | 1 | 7 | 2.1 | COc1ccc(/C=C/C(=O)OC(C)C(=O)[C@H]2C[C@@H]2[C@H](O)[C@H]2CC=CC(=O)O2)cc1 | 10.1016/j.bmcl.2004.08.021 | |||
44395386 | 127605 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 400 | 8 | 1 | 7 | 2.1 | COc1ccc(/C=C\C(=O)OC(C)C(=O)[C@H]2C[C@@H]2[C@H](O)[C@H]2CC=CC(=O)O2)cc1 | 10.1016/j.bmcl.2004.08.021 | |||
CHEMBL366260 | 127605 | None | 0 | Human | Functional | pIC50 | = | 5.1 | 5.1 | - | 1 | ChEMBL | 400 | 8 | 1 | 7 | 2.1 | COc1ccc(/C=C\C(=O)OC(C)C(=O)[C@H]2C[C@@H]2[C@H](O)[C@H]2CC=CC(=O)O2)cc1 | 10.1016/j.bmcl.2004.08.021 | |||
73349500 | 92826 | None | 0 | Human | Functional | pIC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 487 | 8 | 2 | 6 | 4.9 | CC(=O)Nc1ccc(CN2CCC(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 | 10.1016/j.ejmech.2013.09.004 | |||
CHEMBL2436718 | 92826 | None | 0 | Human | Functional | pIC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 487 | 8 | 2 | 6 | 4.9 | CC(=O)Nc1ccc(CN2CCC(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 | 10.1016/j.ejmech.2013.09.004 | |||
50993436 | 57216 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 421 | 6 | 2 | 5 | 3.3 | CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CNCC3)C2)c1ccccc1 | 10.1021/jm100978n | |||
CHEMBL1649915 | 57216 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 421 | 6 | 2 | 5 | 3.3 | CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CNCC3)C2)c1ccccc1 | 10.1021/jm100978n | |||
3008936 | 201152 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 484 | 5 | 0 | 4 | 4.8 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL58109 | 201152 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 484 | 5 | 0 | 4 | 4.8 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1021/jm031046g | |||
126567306 | 165772 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 519 | 8 | 1 | 6 | 6.0 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cccs1 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4244935 | 165772 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 519 | 8 | 1 | 6 | 6.0 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cccs1 | 10.1021/acs.jmedchem.8b01077 | |||
122668196 | 192070 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 501 | 8 | 1 | 6 | 5.9 | Cc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCCCC1)c1ccc(F)s1 | 10.1021/acs.jmedchem.2c01383 | |||
CHEMBL5200961 | 192070 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 501 | 8 | 1 | 6 | 5.9 | Cc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCCCC1)c1ccc(F)s1 | 10.1021/acs.jmedchem.2c01383 | |||
145985894 | 165502 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 569 | 8 | 1 | 6 | 7.2 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1csc2ccccc12 | 10.1021/acs.jmedchem.8b01077 | |||
CHEMBL4238266 | 165502 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 569 | 8 | 1 | 6 | 7.2 | Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1csc2ccccc12 | 10.1021/acs.jmedchem.8b01077 | |||
5275763 | 96844 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 622 | 10 | 1 | 5 | 4.7 | CNC(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(S(C)(=O)=O)CC3)c3ccc(Cl)c(Cl)c3)CC2)cc1 | 10.1021/jm051034q | |||
CHEMBL264832 | 96844 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 622 | 10 | 1 | 5 | 4.7 | CNC(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(S(C)(=O)=O)CC3)c3ccc(Cl)c(Cl)c3)CC2)cc1 | 10.1021/jm051034q | |||
3008925 | 100968 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 492 | 5 | 1 | 3 | 6.5 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2cccc3[nH]ccc23)CC1 | 10.1021/jm031046g | |||
CHEMBL293900 | 100968 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | ChEMBL | 492 | 5 | 1 | 3 | 6.5 | CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2cccc3[nH]ccc23)CC1 | 10.1021/jm031046g | |||
57401041 | 69224 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 568 | 10 | 1 | 6 | 5.9 | COC(=O)c1ccc(N(Cc2ccccc2)C2CCN(C(C)CCNC(=O)c3c(Cl)cncc3Cl)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
CHEMBL1926876 | 69224 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 568 | 10 | 1 | 6 | 5.9 | COC(=O)c1ccc(N(Cc2ccccc2)C2CCN(C(C)CCNC(=O)c3c(Cl)cncc3Cl)CC2)cc1 | 10.1016/j.bmcl.2011.09.133 | |||
10159218 | 13940 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 385 | 7 | 1 | 3 | 3.2 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccccc1)CC2 | 10.1021/jm060051s | |||
CHEMBL1196504 | 13940 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 385 | 7 | 1 | 3 | 3.2 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccccc1)CC2 | 10.1021/jm060051s | |||
CHEMBL557199 | 13940 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 385 | 7 | 1 | 3 | 3.2 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccccc1)CC2 | 10.1021/jm060051s | |||
10159218 | 13940 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 385 | 7 | 1 | 3 | 3.2 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccccc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1196504 | 13940 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 385 | 7 | 1 | 3 | 3.2 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccccc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL557199 | 13940 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 385 | 7 | 1 | 3 | 3.2 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccccc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
10159218 | 13940 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 385 | 7 | 1 | 3 | 3.2 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccccc1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL1196504 | 13940 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 385 | 7 | 1 | 3 | 3.2 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccccc1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL557199 | 13940 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 385 | 7 | 1 | 3 | 3.2 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccccc1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
73351055 | 92827 | None | 0 | Human | Functional | pIC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 471 | 9 | 1 | 4 | 6.2 | CCN(CC)c1ccc(CN2CCC(c3ccc(OC)c(NC(=O)c4ccccc4)c3)CC2)cc1 | 10.1016/j.ejmech.2013.09.004 | |||
CHEMBL2436719 | 92827 | None | 0 | Human | Functional | pIC50 | = | 4.1 | 4.1 | - | 1 | ChEMBL | 471 | 9 | 1 | 4 | 6.2 | CCN(CC)c1ccc(CN2CCC(c3ccc(OC)c(NC(=O)c4ccccc4)c3)CC2)cc1 | 10.1016/j.ejmech.2013.09.004 | |||
118727187 | 117455 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 542 | 8 | 0 | 4 | 5.0 | CC(=O)N1CCC(C(=O)N(CCCN2CCCN(Cc3ccc(F)cc3)CC2)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
CHEMBL3397998 | 117455 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 542 | 8 | 0 | 4 | 5.0 | CC(=O)N1CCC(C(=O)N(CCCN2CCCN(Cc3ccc(F)cc3)CC2)c2ccc(C)c(Cl)c2)CC1 | 10.1016/j.bmc.2014.12.052 | |||
72712374 | 92718 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 457 | 5 | 1 | 3 | 5.3 | O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc3nc[nH]c3c2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435874 | 92718 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 457 | 5 | 1 | 3 | 5.3 | O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc3nc[nH]c3c2)CC1 | 10.1021/jm401101p | |||
72714318 | 92732 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 550 | 8 | 1 | 5 | 5.0 | Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccccc2F)CC1 | 10.1021/jm401101p | |||
CHEMBL2435888 | 92732 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 550 | 8 | 1 | 5 | 5.0 | Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccccc2F)CC1 | 10.1021/jm401101p | |||
3008912 | 203529 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 458 | 4 | 1 | 4 | 5.4 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc4ccn(C)c4c3)CC2)CC1 | 10.1021/jm031046g | |||
CHEMBL60279 | 203529 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 458 | 4 | 1 | 4 | 5.4 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc4ccn(C)c4c3)CC2)CC1 | 10.1021/jm031046g | |||
23577378 | 66453 | None | 0 | Human | Functional | pIC50 | = | 4.0 | 4.0 | - | 1 | ChEMBL | 563 | 10 | 2 | 6 | 4.9 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(OC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813269 | 66453 | None | 0 | Human | Functional | pIC50 | = | 4.0 | 4.0 | - | 1 | ChEMBL | 563 | 10 | 2 | 6 | 4.9 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(OC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851957 | 66453 | None | 0 | Human | Functional | pIC50 | = | 4.0 | 4.0 | - | 1 | ChEMBL | 563 | 10 | 2 | 6 | 4.9 | CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(OC)cc3)cc1)CC2 | 10.1016/j.bmc.2011.05.022 | |||
21064289 | 14407 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 535 | 9 | 1 | 4 | 6.1 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(F)cc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1173647 | 14407 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 535 | 9 | 1 | 4 | 6.1 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(F)cc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1200295 | 14407 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 535 | 9 | 1 | 4 | 6.1 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(F)cc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
46226130 | 14120 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 549 | 10 | 1 | 4 | 6.1 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(F)cc3)c1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL1198009 | 14120 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 549 | 10 | 1 | 4 | 6.1 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(F)cc3)c1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL593111 | 14120 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 549 | 10 | 1 | 4 | 6.1 | CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(F)cc3)c1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
46225527 | 202150 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 571 | 6 | 0 | 6 | 3.3 | Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCOC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL593184 | 202150 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 571 | 6 | 0 | 6 | 3.3 | Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCOC4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
62707282 | 77205 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 286 | 8 | 0 | 0 | 5.3 | CCCCCCCC/C=C\c1c(C)cc(C)[n+]2c1CCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL2057534 | 77205 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 286 | 8 | 0 | 0 | 5.3 | CCCCCCCC/C=C\c1c(C)cc(C)[n+]2c1CCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL2078850 | 77205 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 286 | 8 | 0 | 0 | 5.3 | CCCCCCCC/C=C\c1c(C)cc(C)[n+]2c1CCC2 | 10.1016/j.bmcl.2012.05.127 | |||
54752875 | 77219 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c(C)[n+]2c1CCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL2057813 | 77219 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c(C)[n+]2c1CCC2 | 10.1016/j.bmcl.2012.05.127 | |||
CHEMBL2079028 | 77219 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c(C)[n+]2c1CCC2 | 10.1016/j.bmcl.2012.05.127 | |||
62707282 | 77205 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 286 | 8 | 0 | 0 | 5.3 | CCCCCCCC/C=C\c1c(C)cc(C)[n+]2c1CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL2057534 | 77205 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 286 | 8 | 0 | 0 | 5.3 | CCCCCCCC/C=C\c1c(C)cc(C)[n+]2c1CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL2078850 | 77205 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 286 | 8 | 0 | 0 | 5.3 | CCCCCCCC/C=C\c1c(C)cc(C)[n+]2c1CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
54752875 | 77219 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c(C)[n+]2c1CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL2057813 | 77219 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c(C)[n+]2c1CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL2079028 | 77219 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 424 | 16 | 0 | 0 | 9.1 | CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c(C)[n+]2c1CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
70692903 | 77236 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 286 | 8 | 0 | 0 | 5.3 | CCCCCCCC/C=C/c1c(C)cc(C)[n+]2c1CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL2064265 | 77236 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 286 | 8 | 0 | 0 | 5.3 | CCCCCCCC/C=C/c1c(C)cc(C)[n+]2c1CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
CHEMBL2079297 | 77236 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 286 | 8 | 0 | 0 | 5.3 | CCCCCCCC/C=C/c1c(C)cc(C)[n+]2c1CCC2 | 10.1016/j.ejmech.2012.07.049 | |||
73352528 | 92822 | None | 0 | Human | Functional | pIC50 | = | 4.0 | 4.0 | - | 1 | ChEMBL | 485 | 8 | 2 | 4 | 6.1 | CC(=O)Nc1ccc(CN2CCC(c3ccc(OC(C)C)c(NC(=O)c4ccccc4)c3)CC2)cc1 | 10.1016/j.ejmech.2013.09.004 | |||
CHEMBL2436714 | 92822 | None | 0 | Human | Functional | pIC50 | = | 4.0 | 4.0 | - | 1 | ChEMBL | 485 | 8 | 2 | 4 | 6.1 | CC(=O)Nc1ccc(CN2CCC(c3ccc(OC(C)C)c(NC(=O)c4ccccc4)c3)CC2)cc1 | 10.1016/j.ejmech.2013.09.004 | |||
46225526 | 202189 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 523 | 6 | 0 | 5 | 3.3 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
CHEMBL593520 | 202189 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 523 | 6 | 0 | 5 | 3.3 | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 | 10.1016/j.bmcl.2009.11.072 | |||
57331306 | 104636 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 600 | 10 | 0 | 4 | 5.7 | CCN(Cc1ccc(Cl)cc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
CHEMBL3104679 | 104636 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 600 | 10 | 0 | 4 | 5.7 | CCN(Cc1ccc(Cl)cc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 | 10.1016/j.ejmech.2013.11.013 | |||
491775 | 12882 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
CHEMBL1188807 | 12882 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
CHEMBL537424 | 12882 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2006.10.084 | |||
491775 | 12882 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL1188807 | 12882 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
CHEMBL537424 | 12882 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2010.12.109 | |||
491775 | 12882 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL1188807 | 12882 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
CHEMBL537424 | 12882 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmc.2010.05.057 | |||
491775 | 12882 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL1188807 | 12882 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
CHEMBL537424 | 12882 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 477 | 9 | 1 | 4 | 5.0 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 | 10.1016/j.bmcl.2009.11.018 | |||
162677463 | 183682 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 857 | 23 | 5 | 11 | 4.1 | CNC(=O)COCC(=O)NCCCCCNC(=O)COCC(=O)Nc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)cc1 | 10.1016/j.bmc.2016.09.059 | |||
CHEMBL4800480 | 183682 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 857 | 23 | 5 | 11 | 4.1 | CNC(=O)COCC(=O)NCCCCCNC(=O)COCC(=O)Nc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)cc1 | 10.1016/j.bmc.2016.09.059 | |||
CHEMBL5089300 | 217691 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | -13 | 2 | ChEMBL | None | None | None | CC(C)c1nnc(CCNC(=O)COCC(=O)NCCCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)n1C1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1 | 10.1021/acs.jmedchem.1c00408 | |||||
90656334 | 111133 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 489 | 8 | 1 | 8 | 3.6 | COC(=O)c1ccc(CN2CCN(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 | 10.1016/j.bmcl.2014.03.073 | |||
CHEMBL3263030 | 111133 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 489 | 8 | 1 | 8 | 3.6 | COC(=O)c1ccc(CN2CCN(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 | 10.1016/j.bmcl.2014.03.073 | |||
23577328 | 66455 | None | 0 | Human | Functional | pIC50 | = | 4.0 | 4.0 | - | 1 | ChEMBL | 592 | 10 | 3 | 7 | 3.1 | CNC(=O)c1ccc(Oc2ccc(CN3CCC4(CC3)C(=O)N[C@H]([C@H](O)C3CCCCC3)C(=O)N4CCOC)cc2)cc1 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1813454 | 66455 | None | 0 | Human | Functional | pIC50 | = | 4.0 | 4.0 | - | 1 | ChEMBL | 592 | 10 | 3 | 7 | 3.1 | CNC(=O)c1ccc(Oc2ccc(CN3CCC4(CC3)C(=O)N[C@H]([C@H](O)C3CCCCC3)C(=O)N4CCOC)cc2)cc1 | 10.1016/j.bmc.2011.05.022 | |||
CHEMBL1851967 | 66455 | None | 0 | Human | Functional | pIC50 | = | 4.0 | 4.0 | - | 1 | ChEMBL | 592 | 10 | 3 | 7 | 3.1 | CNC(=O)c1ccc(Oc2ccc(CN3CCC4(CC3)C(=O)N[C@H]([C@H](O)C3CCCCC3)C(=O)N4CCOC)cc2)cc1 | 10.1016/j.bmc.2011.05.022 | |||
60196353 | 81654 | None | 0 | Human | Functional | pKd | = | 8.8 | 8.8 | - | 0 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | Cc1nnc(C(C)C)n1C1C[C@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1 | 10.1021/acs.jmedchem.6b01801 | |||
CHEMBL2163486 | 81654 | None | 0 | Human | Functional | pKd | = | 8.8 | 8.8 | - | 0 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | Cc1nnc(C(C)C)n1C1C[C@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1 | 10.1021/acs.jmedchem.6b01801 | |||
137643501 | 158485 | None | 0 | Human | Functional | pKd | = | 8 | 8.0 | - | 0 | ChEMBL | 471 | 6 | 1 | 5 | 4.5 | Cc1nnc2n1[C@@H]1CCN(CC[C@H](NC(=O)C3CCC(F)(F)CC3)c3ccccc3)C[C@@H]1CC2 | 10.1021/acs.jmedchem.6b01801 | |||
CHEMBL4089991 | 158485 | None | 0 | Human | Functional | pKd | = | 8 | 8.0 | - | 0 | ChEMBL | 471 | 6 | 1 | 5 | 4.5 | Cc1nnc2n1[C@@H]1CCN(CC[C@H](NC(=O)C3CCC(F)(F)CC3)c3ccccc3)C[C@@H]1CC2 | 10.1021/acs.jmedchem.6b01801 | |||
137631641 | 156700 | None | 0 | Human | Functional | pKd | = | 6.5 | 6.5 | - | 0 | ChEMBL | 471 | 6 | 1 | 5 | 4.5 | Cc1nnc2n1[C@H]1CCN(CC[C@H](NC(=O)C3CCC(F)(F)CC3)c3ccccc3)C[C@H]1CC2 | 10.1021/acs.jmedchem.6b01801 | |||
CHEMBL4068906 | 156700 | None | 0 | Human | Functional | pKd | = | 6.5 | 6.5 | - | 0 | ChEMBL | 471 | 6 | 1 | 5 | 4.5 | Cc1nnc2n1[C@H]1CCN(CC[C@H](NC(=O)C3CCC(F)(F)CC3)c3ccccc3)C[C@H]1CC2 | 10.1021/acs.jmedchem.6b01801 | |||
3009353 | 168128 | None | 0 | Human | Functional | pKi | = | 9.0 | 9.0 | - | 0 | ChEMBL | 531 | 6 | 0 | 5 | 5.7 | CCC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C | 10.1021/jm0304515 | |||
CHEMBL432170 | 168128 | None | 0 | Human | Functional | pKi | = | 9.0 | 9.0 | - | 0 | ChEMBL | 531 | 6 | 0 | 5 | 5.7 | CCC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C | 10.1021/jm0304515 | |||
3009354 | 207734 | None | 0 | Human | Functional | pKi | = | 8.9 | 8.9 | - | 0 | ChEMBL | 579 | 6 | 0 | 5 | 6.1 | Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](Cc3ccccc3)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1 | 10.1021/jm0304515 | |||
CHEMBL79061 | 207734 | None | 0 | Human | Functional | pKi | = | 8.9 | 8.9 | - | 0 | ChEMBL | 579 | 6 | 0 | 5 | 6.1 | Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](Cc3ccccc3)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1 | 10.1021/jm0304515 | |||
3009356 | 105679 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 543 | 6 | 0 | 5 | 5.7 | Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](CC3CC3)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1 | 10.1021/jm0304515 | |||
CHEMBL312344 | 105679 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 543 | 6 | 0 | 5 | 5.7 | Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](CC3CC3)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1 | 10.1021/jm0304515 | |||
3009355 | 3989 | None | 18 | Human | Functional | pKi | = | 8.6 | 8.6 | -1 | 2 | ChEMBL | 533 | 6 | 0 | 6 | 4.5 | COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F | 10.1021/jm0304515 | |||
807 | 3989 | None | 18 | Human | Functional | pKi | = | 8.6 | 8.6 | -1 | 2 | ChEMBL | 533 | 6 | 0 | 6 | 4.5 | COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F | 10.1021/jm0304515 | |||
CHEMBL82301 | 3989 | None | 18 | Human | Functional | pKi | = | 8.6 | 8.6 | -1 | 2 | ChEMBL | 533 | 6 | 0 | 6 | 4.5 | COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F | 10.1021/jm0304515 | |||
DB06652 | 3989 | None | 18 | Human | Functional | pKi | = | 8.6 | 8.6 | -1 | 2 | ChEMBL | 533 | 6 | 0 | 6 | 4.5 | COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F | 10.1021/jm0304515 | |||
483747 | 105465 | None | 1 | Human | Functional | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 503 | 4 | 0 | 5 | 4.9 | Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1 | 10.1021/jm0304515 | |||
CHEMBL311795 | 105465 | None | 1 | Human | Functional | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 503 | 4 | 0 | 5 | 4.9 | Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1 | 10.1021/jm0304515 | |||
10436045 | 3516 | None | 4 | Human | Functional | pKi | = | 5.4 | 5.4 | - | 1 | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(00)00347-4 | |||
782 | 3516 | None | 4 | Human | Functional | pKi | = | 5.4 | 5.4 | - | 1 | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(00)00347-4 | |||
CHEMBL432713 | 3516 | None | 4 | Human | Functional | pKi | = | 5.4 | 5.4 | - | 1 | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(00)00347-4 | |||
3009352 | 96692 | None | 0 | Human | Functional | pKi | = | 8.3 | 8.3 | - | 0 | ChEMBL | 517 | 5 | 0 | 5 | 5.3 | CC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C | 10.1021/jm0304515 | |||
CHEMBL263555 | 96692 | None | 0 | Human | Functional | pKi | = | 8.3 | 8.3 | - | 0 | ChEMBL | 517 | 5 | 0 | 5 | 5.3 | CC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C | 10.1021/jm0304515 | |||
15664 | 83821 | None | 63 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 2 | 3 | Drug Central | 184 | 1 | 0 | 2 | 2.8 | Cc1ccc(-c2ccc(C)cn2)nc1 | None | |||
CHEMBL2205807 | 83821 | None | 63 | Human | Functional | pEC50 | = | 8.3 | 8.3 | 2 | 3 | Drug Central | 184 | 1 | 0 | 2 | 2.8 | Cc1ccc(-c2ccc(C)cn2)nc1 | None | |||
10585 | 1079 | None | 1 | Human | Functional | pIC50 | = | 7.1 | 7.1 | -1 | 2 | Guide to Pharmacology | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 31742400 | |||
145996522 | 1079 | None | 1 | Human | Functional | pIC50 | = | 7.1 | 7.1 | -1 | 2 | Guide to Pharmacology | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 31742400 | |||
CHEMBL4531005 | 1079 | None | 1 | Human | Functional | pIC50 | = | 7.1 | 7.1 | -1 | 2 | Guide to Pharmacology | 351 | 3 | 2 | 5 | 3.0 | Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C | 31742400 | |||
10106 | 873 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | Guide to Pharmacology | 519 | 8 | 1 | 6 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccsc1)CCN1[C@@H]2CC[C@H]1C[C@@H](C2)n1c(C)nnc1C(C)C | 30234300 | |||
91820689 | 873 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | Guide to Pharmacology | 519 | 8 | 1 | 6 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccsc1)CCN1[C@@H]2CC[C@H]1C[C@@H](C2)n1c(C)nnc1C(C)C | 30234300 | |||
CHEMBL4249798 | 873 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | Guide to Pharmacology | 519 | 8 | 1 | 6 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccsc1)CCN1[C@@H]2CC[C@H]1C[C@@H](C2)n1c(C)nnc1C(C)C | 30234300 | |||
10750 | 2579 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -5011 | 2 | Guide to Pharmacology | 532 | 5 | 2 | 5 | 6.3 | Clc1ccc(cc1)C1(O)CCN(CC1(C)C)CC/C=C\1/c2cc(ccc2OCc2c1cccn2)C(O)(C)C | 17715391 | |||
18437138 | 2579 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -5011 | 2 | Guide to Pharmacology | 532 | 5 | 2 | 5 | 6.3 | Clc1ccc(cc1)C1(O)CCN(CC1(C)C)CC/C=C\1/c2cc(ccc2OCc2c1cccn2)C(O)(C)C | 17715391 | |||
11597 | 674 | None | 6 | Human | Functional | pIC50 | = | 7.1 | 7.1 | -11 | 2 | Guide to Pharmacology | 506 | 5 | 3 | 6 | 3.5 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C | 34141082 | |||
23725180 | 674 | None | 6 | Human | Functional | pIC50 | = | 7.1 | 7.1 | -11 | 2 | Guide to Pharmacology | 506 | 5 | 3 | 6 | 3.5 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C | 34141082 | |||
CHEMBL4781426 | 674 | None | 6 | Human | Functional | pIC50 | = | 7.1 | 7.1 | -11 | 2 | Guide to Pharmacology | 506 | 5 | 3 | 6 | 3.5 | CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C | 34141082 | |||
769 | 827 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | -14 | 3 | Guide to Pharmacology | None | None | None | None | 10477718 | |||||
3002977 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 4 | Guide to Pharmacology | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 16298345 | |||
3002977.0 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 4 | Guide to Pharmacology | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 16298345 | |||
803 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 4 | Guide to Pharmacology | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 16298345 | |||
806 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 4 | Guide to Pharmacology | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 16298345 | |||
CHEMBL1201187 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 4 | Guide to Pharmacology | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 16298345 | |||
CHEMBL256907 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 4 | Guide to Pharmacology | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 16298345 | |||
CHEMBL584744 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 4 | Guide to Pharmacology | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 16298345 | |||
DB04835 | 2460 | None | 43 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 2 | 4 | Guide to Pharmacology | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 16298345 | |||
486830 | 4002 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -6 | 5 | Guide to Pharmacology | None | None | None | None | 9287217 | |||||
768 | 4002 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -6 | 5 | Guide to Pharmacology | None | None | None | None | 9287217 | |||||
68764898 | 672 | None | 2 | Human | Functional | pIC50 | = | 8.6 | 8.6 | -3 | 2 | Guide to Pharmacology | 491 | 7 | 1 | 5 | 5.3 | CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 25893046 | |||
9430 | 672 | None | 2 | Human | Functional | pIC50 | = | 8.6 | 8.6 | -3 | 2 | Guide to Pharmacology | 491 | 7 | 1 | 5 | 5.3 | CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 25893046 | |||
CHEMBL3577945 | 672 | None | 2 | Human | Functional | pIC50 | = | 8.6 | 8.6 | -3 | 2 | Guide to Pharmacology | 491 | 7 | 1 | 5 | 5.3 | CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C | 25893046 | |||
3500 | 1526 | None | 13 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 245 | 2 | Guide to Pharmacology | 483 | 7 | 1 | 5 | 3.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C21CCN(CC2)Cc1ccc2c(c1)OCCO2 | 11454872 | |||
491774 | 1526 | None | 13 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 245 | 2 | Guide to Pharmacology | 483 | 7 | 1 | 5 | 3.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C21CCN(CC2)Cc1ccc2c(c1)OCCO2 | 11454872 | |||
CHEMBL1196395 | 1526 | None | 13 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 245 | 2 | Guide to Pharmacology | 483 | 7 | 1 | 5 | 3.9 | CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C21CCN(CC2)Cc1ccc2c(c1)OCCO2 | 11454872 | |||
5275766 | 3738 | None | 34 | Human | Functional | pIC50 | None | 8.5 | 8.5 | - | 1 | Guide to Pharmacology | 552 | 9 | 1 | 4 | 4.7 | CC(=O)N1CCC(CC1)C(=O)N(c1ccc(c(c1)Cl)C)CCCN1CCC(CC1)Cc1ccc(cc1)C(=O)N | 16640339 | |||
800 | 3738 | None | 34 | Human | Functional | pIC50 | None | 8.5 | 8.5 | - | 1 | Guide to Pharmacology | 552 | 9 | 1 | 4 | 4.7 | CC(=O)N1CCC(CC1)C(=O)N(c1ccc(c(c1)Cl)C)CCCN1CCC(CC1)Cc1ccc(cc1)C(=O)N | 16640339 | |||
CHEMBL207004 | 3738 | None | 34 | Human | Functional | pIC50 | None | 8.5 | 8.5 | - | 1 | Guide to Pharmacology | 552 | 9 | 1 | 4 | 4.7 | CC(=O)N1CCC(CC1)C(=O)N(c1ccc(c(c1)Cl)C)CCCN1CCC(CC1)Cc1ccc(cc1)C(=O)N | 16640339 | |||
11285792 | 879 | None | 32 | Human | Functional | pIC50 | None | 8.6 | 8.6 | -3 | 6 | Guide to Pharmacology | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 16251299 | |||
801 | 879 | None | 32 | Human | Functional | pIC50 | None | 8.6 | 8.6 | -3 | 6 | Guide to Pharmacology | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 16251299 | |||
CHEMBL2110727 | 879 | None | 32 | Human | Functional | pIC50 | None | 8.6 | 8.6 | -3 | 6 | Guide to Pharmacology | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 16251299 | |||
DB11758 | 879 | None | 32 | Human | Functional | pIC50 | None | 8.6 | 8.6 | -3 | 6 | Guide to Pharmacology | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 16251299 |
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
CHEMBL2372983 | 212790 | None | 0 | Human | Binding | pEC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | None | None | None | NCCCC[C@@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C1=O | 10.1016/s0960-894x(00)00664-8 | |||||
3002977 | 2460 | None | 43 | Human | Binding | pEC50 | = | 9 | 9.0 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1039/C6MD00311G | |||
3002977.0 | 2460 | None | 43 | Human | Binding | pEC50 | = | 9 | 9.0 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1039/C6MD00311G | |||
803 | 2460 | None | 43 | Human | Binding | pEC50 | = | 9 | 9.0 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1039/C6MD00311G | |||
806 | 2460 | None | 43 | Human | Binding | pEC50 | = | 9 | 9.0 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1039/C6MD00311G | |||
CHEMBL1201187 | 2460 | None | 43 | Human | Binding | pEC50 | = | 9 | 9.0 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1039/C6MD00311G | |||
CHEMBL256907 | 2460 | None | 43 | Human | Binding | pEC50 | = | 9 | 9.0 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1039/C6MD00311G | |||
CHEMBL584744 | 2460 | None | 43 | Human | Binding | pEC50 | = | 9 | 9.0 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1039/C6MD00311G | |||
DB04835 | 2460 | None | 43 | Human | Binding | pEC50 | = | 9 | 9.0 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1039/C6MD00311G | |||
129908110 | 156046 | None | 0 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 485 | 9 | 1 | 6 | 5.3 | CC(=O)Oc1ccc(/C=C/C(=O)CCc2ccc(NC(=O)c3ccc(C)cc3)cc2)cc1OC(C)=O | 10.1039/C6MD00311G | |||
CHEMBL4061273 | 156046 | None | 0 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 485 | 9 | 1 | 6 | 5.3 | CC(=O)Oc1ccc(/C=C/C(=O)CCc2ccc(NC(=O)c3ccc(C)cc3)cc2)cc1OC(C)=O | 10.1039/C6MD00311G | |||
129908195 | 158881 | None | 0 | Human | Binding | pEC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 493 | 11 | 1 | 7 | 4.9 | CC(=O)Oc1ccc(CCC(=O)CCc2ccc(NC(=O)Cc3cccs3)cc2)cc1OC(C)=O | 10.1039/C6MD00311G | |||
CHEMBL4094196 | 158881 | None | 0 | Human | Binding | pEC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 493 | 11 | 1 | 7 | 4.9 | CC(=O)Oc1ccc(CCC(=O)CCc2ccc(NC(=O)Cc3cccs3)cc2)cc1OC(C)=O | 10.1039/C6MD00311G | |||
129908301 | 156790 | None | 0 | Human | Binding | pEC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 516 | 10 | 1 | 8 | 4.9 | CC(=O)Oc1ccc(/C=C/C(=O)CCc2ccc(NC(=O)c3ccc([N+](=O)[O-])cc3)cc2)cc1OC(C)=O | 10.1039/C6MD00311G | |||
132519568 | 156790 | None | 0 | Human | Binding | pEC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 516 | 10 | 1 | 8 | 4.9 | CC(=O)Oc1ccc(/C=C/C(=O)CCc2ccc(NC(=O)c3ccc([N+](=O)[O-])cc3)cc2)cc1OC(C)=O | 10.1039/C6MD00311G | |||
CHEMBL4069939 | 156790 | None | 0 | Human | Binding | pEC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 516 | 10 | 1 | 8 | 4.9 | CC(=O)Oc1ccc(/C=C/C(=O)CCc2ccc(NC(=O)c3ccc([N+](=O)[O-])cc3)cc2)cc1OC(C)=O | 10.1039/C6MD00311G | |||
129908428 | 159045 | None | 0 | Human | Binding | pEC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 417 | 8 | 3 | 5 | 4.6 | COc1ccc(C(=O)Nc2ccc(CCC(=O)/C=C/c3ccc(O)c(O)c3)cc2)cc1 | 10.1039/C6MD00311G | |||
CHEMBL4095938 | 159045 | None | 0 | Human | Binding | pEC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 417 | 8 | 3 | 5 | 4.6 | COc1ccc(C(=O)Nc2ccc(CCC(=O)/C=C/c3ccc(O)c(O)c3)cc2)cc1 | 10.1039/C6MD00311G | |||
129908452 | 156123 | None | 0 | Human | Binding | pEC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 518 | 11 | 1 | 8 | 4.8 | CC(=O)Oc1ccc(CCC(=O)CCc2ccc(NC(=O)c3ccc([N+](=O)[O-])cc3)cc2)cc1OC(C)=O | 10.1039/C6MD00311G | |||
CHEMBL4062349 | 156123 | None | 0 | Human | Binding | pEC50 | = | 4.8 | 4.8 | - | 0 | ChEMBL | 518 | 11 | 1 | 8 | 4.8 | CC(=O)Oc1ccc(CCC(=O)CCc2ccc(NC(=O)c3ccc([N+](=O)[O-])cc3)cc2)cc1OC(C)=O | 10.1039/C6MD00311G | |||
3002977 | 2460 | None | 43 | Human | Binding | pEC50 | = | 7.8 | 7.8 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.1c00408 | |||
3002977.0 | 2460 | None | 43 | Human | Binding | pEC50 | = | 7.8 | 7.8 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.1c00408 | |||
803 | 2460 | None | 43 | Human | Binding | pEC50 | = | 7.8 | 7.8 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.1c00408 | |||
806 | 2460 | None | 43 | Human | Binding | pEC50 | = | 7.8 | 7.8 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.1c00408 | |||
CHEMBL1201187 | 2460 | None | 43 | Human | Binding | pEC50 | = | 7.8 | 7.8 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.1c00408 | |||
CHEMBL256907 | 2460 | None | 43 | Human | Binding | pEC50 | = | 7.8 | 7.8 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.1c00408 | |||
CHEMBL584744 | 2460 | None | 43 | Human | Binding | pEC50 | = | 7.8 | 7.8 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.1c00408 | |||
DB04835 | 2460 | None | 43 | Human | Binding | pEC50 | = | 7.8 | 7.8 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/acs.jmedchem.1c00408 | |||
129908456 | 157966 | None | 0 | Human | Binding | pEC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 395 | 8 | 3 | 4 | 4.8 | O=C(CCc1ccc(NC(=O)C2CCCCC2)cc1)CCc1ccc(O)c(O)c1 | 10.1039/C6MD00311G | |||
CHEMBL4083941 | 157966 | None | 0 | Human | Binding | pEC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 395 | 8 | 3 | 4 | 4.8 | O=C(CCc1ccc(NC(=O)C2CCCCC2)cc1)CCc1ccc(O)c(O)c1 | 10.1039/C6MD00311G | |||
129908453 | 157978 | None | 0 | Human | Binding | pEC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 479 | 10 | 1 | 6 | 5.2 | CC(=O)Oc1ccc(CCC(=O)CCc2ccc(NC(=O)C3CCCCC3)cc2)cc1OC(C)=O | 10.1039/C6MD00311G | |||
CHEMBL4084066 | 157978 | None | 0 | Human | Binding | pEC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 479 | 10 | 1 | 6 | 5.2 | CC(=O)Oc1ccc(CCC(=O)CCc2ccc(NC(=O)C3CCCCC3)cc2)cc1OC(C)=O | 10.1039/C6MD00311G | |||
129908111 | 157762 | None | 0 | Human | Binding | pEC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 501 | 10 | 1 | 7 | 5.0 | COc1ccc(C(=O)Nc2ccc(CCC(=O)/C=C/c3ccc(OC(C)=O)c(OC(C)=O)c3)cc2)cc1 | 10.1039/C6MD00311G | |||
CHEMBL4081563 | 157762 | None | 0 | Human | Binding | pEC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 501 | 10 | 1 | 7 | 5.0 | COc1ccc(C(=O)Nc2ccc(CCC(=O)/C=C/c3ccc(OC(C)=O)c(OC(C)=O)c3)cc2)cc1 | 10.1039/C6MD00311G | |||
129908196 | 157122 | None | 0 | Human | Binding | pEC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 389 | 8 | 3 | 4 | 4.5 | O=C(CCc1ccc(NC(=O)c2ccccc2)cc1)CCc1ccc(O)c(O)c1 | 10.1039/C6MD00311G | |||
CHEMBL4073567 | 157122 | None | 0 | Human | Binding | pEC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 389 | 8 | 3 | 4 | 4.5 | O=C(CCc1ccc(NC(=O)c2ccccc2)cc1)CCc1ccc(O)c(O)c1 | 10.1039/C6MD00311G | |||
129908454 | 158178 | None | 0 | Human | Binding | pEC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 487 | 10 | 1 | 6 | 5.2 | CC(=O)Oc1ccc(CCC(=O)CCc2ccc(NC(=O)c3ccc(C)cc3)cc2)cc1OC(C)=O | 10.1039/C6MD00311G | |||
CHEMBL4086440 | 158178 | None | 0 | Human | Binding | pEC50 | = | 4.6 | 4.6 | - | 0 | ChEMBL | 487 | 10 | 1 | 6 | 5.2 | CC(=O)Oc1ccc(CCC(=O)CCc2ccc(NC(=O)c3ccc(C)cc3)cc2)cc1OC(C)=O | 10.1039/C6MD00311G | |||
129908109 | 158434 | None | 0 | Human | Binding | pEC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 477 | 9 | 1 | 6 | 5.3 | CC(=O)Oc1ccc(/C=C/C(=O)CCc2ccc(NC(=O)C3CCCCC3)cc2)cc1OC(C)=O | 10.1039/C6MD00311G | |||
CHEMBL4089429 | 158434 | None | 0 | Human | Binding | pEC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 477 | 9 | 1 | 6 | 5.3 | CC(=O)Oc1ccc(/C=C/C(=O)CCc2ccc(NC(=O)C3CCCCC3)cc2)cc1OC(C)=O | 10.1039/C6MD00311G | |||
129908455 | 156352 | None | 0 | Human | Binding | pEC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 503 | 11 | 1 | 7 | 4.9 | COc1ccc(C(=O)Nc2ccc(CCC(=O)CCc3ccc(OC(C)=O)c(OC(C)=O)c3)cc2)cc1 | 10.1039/C6MD00311G | |||
CHEMBL4064975 | 156352 | None | 0 | Human | Binding | pEC50 | = | 4.5 | 4.5 | - | 0 | ChEMBL | 503 | 11 | 1 | 7 | 4.9 | COc1ccc(C(=O)Nc2ccc(CCC(=O)CCc3ccc(OC(C)=O)c(OC(C)=O)c3)cc2)cc1 | 10.1039/C6MD00311G | |||
129908558 | 156264 | None | 0 | Human | Binding | pEC50 | = | 4.4 | 4.4 | - | 0 | ChEMBL | 403 | 8 | 3 | 4 | 4.8 | Cc1ccc(C(=O)Nc2ccc(CCC(=O)CCc3ccc(O)c(O)c3)cc2)cc1 | 10.1039/C6MD00311G | |||
CHEMBL4063935 | 156264 | None | 0 | Human | Binding | pEC50 | = | 4.4 | 4.4 | - | 0 | ChEMBL | 403 | 8 | 3 | 4 | 4.8 | Cc1ccc(C(=O)Nc2ccc(CCC(=O)CCc3ccc(O)c(O)c3)cc2)cc1 | 10.1039/C6MD00311G | |||
129907953 | 159597 | None | 0 | Human | Binding | pEC50 | = | 4.4 | 4.4 | - | 0 | ChEMBL | 434 | 9 | 3 | 6 | 4.4 | O=C(CCc1ccc(NC(=O)c2ccc([N+](=O)[O-])cc2)cc1)CCc1ccc(O)c(O)c1 | 10.1039/C6MD00311G | |||
132519569 | 159597 | None | 0 | Human | Binding | pEC50 | = | 4.4 | 4.4 | - | 0 | ChEMBL | 434 | 9 | 3 | 6 | 4.4 | O=C(CCc1ccc(NC(=O)c2ccc([N+](=O)[O-])cc2)cc1)CCc1ccc(O)c(O)c1 | 10.1039/C6MD00311G | |||
CHEMBL4101931 | 159597 | None | 0 | Human | Binding | pEC50 | = | 4.4 | 4.4 | - | 0 | ChEMBL | 434 | 9 | 3 | 6 | 4.4 | O=C(CCc1ccc(NC(=O)c2ccc([N+](=O)[O-])cc2)cc1)CCc1ccc(O)c(O)c1 | 10.1039/C6MD00311G | |||
129908281 | 158666 | None | 0 | Human | Binding | pEC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 473 | 10 | 1 | 6 | 4.9 | CC(=O)Oc1ccc(CCC(=O)CCc2ccc(NC(=O)c3ccccc3)cc2)cc1OC(C)=O | 10.1039/C6MD00311G | |||
CHEMBL4091826 | 158666 | None | 0 | Human | Binding | pEC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 473 | 10 | 1 | 6 | 4.9 | CC(=O)Oc1ccc(CCC(=O)CCc2ccc(NC(=O)c3ccccc3)cc2)cc1OC(C)=O | 10.1039/C6MD00311G | |||
129908560 | 157023 | None | 0 | Human | Binding | pEC50 | = | 4.3 | 4.3 | - | 0 | ChEMBL | 409 | 9 | 3 | 5 | 4.5 | O=C(CCc1ccc(NC(=O)Cc2cccs2)cc1)CCc1ccc(O)c(O)c1 | 10.1039/C6MD00311G | |||
CHEMBL4072528 | 157023 | None | 0 | Human | Binding | pEC50 | = | 4.3 | 4.3 | - | 0 | ChEMBL | 409 | 9 | 3 | 5 | 4.5 | O=C(CCc1ccc(NC(=O)Cc2cccs2)cc1)CCc1ccc(O)c(O)c1 | 10.1039/C6MD00311G | |||
CHEMBL5074744 | 216817 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 2 | ChEMBL | None | None | None | CC(C)c1nnc(CCNC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)n1C1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1 | 10.1021/acs.jmedchem.1c00408 | |||||
483747 | 105465 | None | 1 | Human | Binding | pIC50 | = | 11 | 11.0 | 177 | 4 | ChEMBL | 503 | 4 | 0 | 5 | 4.9 | Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1 | 10.1016/s0960-894x(02)00918-6 | |||
CHEMBL311795 | 105465 | None | 1 | Human | Binding | pIC50 | = | 11 | 11.0 | 177 | 4 | ChEMBL | 503 | 4 | 0 | 5 | 4.9 | Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1 | 10.1016/s0960-894x(02)00918-6 | |||
44590586 | 176915 | None | 0 | Human | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | ChEMBL | 543 | 10 | 1 | 3 | 6.3 | CCN(C(=O)Cc1ccc(Cl)c(Cl)c1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 | 10.1016/j.bmcl.2009.01.009 | |||
CHEMBL460845 | 176915 | None | 0 | Human | Binding | pIC50 | = | 10.3 | 10.3 | - | 0 | ChEMBL | 543 | 10 | 1 | 3 | 6.3 | CCN(C(=O)Cc1ccc(Cl)c(Cl)c1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 | 10.1016/j.bmcl.2009.01.009 | |||
10076141 | 78420 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 546 | 11 | 1 | 3 | 6.5 | O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL21106 | 78420 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 546 | 11 | 1 | 3 | 6.5 | O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
10076141 | 78420 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 546 | 11 | 1 | 3 | 6.5 | O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
CHEMBL21106 | 78420 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 546 | 11 | 1 | 3 | 6.5 | O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
CHEMBL181276 | 211440 | None | 44 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | None | None | None | C[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(N)=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O | 10.1016/j.ejmech.2020.112819 | |||||
10076141 | 78420 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 546 | 11 | 1 | 3 | 6.5 | O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL21106 | 78420 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 546 | 11 | 1 | 3 | 6.5 | O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
44590681 | 175277 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 553 | 11 | 1 | 5 | 4.4 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 | 10.1016/j.bmcl.2009.01.009 | |||
CHEMBL457043 | 175277 | None | 0 | Human | Binding | pIC50 | = | 10.2 | 10.2 | - | 0 | ChEMBL | 553 | 11 | 1 | 5 | 4.4 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 | 10.1016/j.bmcl.2009.01.009 | |||
44273531 | 75058 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 542 | 11 | 1 | 4 | 6.5 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCSc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
CHEMBL20345 | 75058 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 542 | 11 | 1 | 4 | 6.5 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCSc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
501062 | 77763 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 488 | 11 | 1 | 3 | 6.1 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
CHEMBL20896 | 77763 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 488 | 11 | 1 | 3 | 6.1 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
501062 | 77763 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 488 | 11 | 1 | 3 | 6.1 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2005.02.030 | |||
CHEMBL20896 | 77763 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 488 | 11 | 1 | 3 | 6.1 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2005.02.030 | |||
44273531 | 75058 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 542 | 11 | 1 | 4 | 6.5 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCSc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL20345 | 75058 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 542 | 11 | 1 | 4 | 6.5 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCSc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
44332684 | 107236 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 474 | 11 | 1 | 3 | 5.7 | O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL316475 | 107236 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 474 | 11 | 1 | 3 | 5.7 | O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
501060 | 108642 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 474 | 10 | 1 | 3 | 5.7 | O=C(O)[C@@H](C1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL320386 | 108642 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 474 | 10 | 1 | 3 | 5.7 | O=C(O)[C@@H](C1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
501055 | 4615 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 502 | 10 | 1 | 3 | 6.5 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/s0960-894x(02)00606-6 | |||
CHEMBL102826 | 4615 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 502 | 10 | 1 | 3 | 6.5 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/s0960-894x(02)00606-6 | |||
501062 | 77763 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 488 | 11 | 1 | 3 | 6.1 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/s0960-894x(02)00606-6 | |||
CHEMBL20896 | 77763 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 488 | 11 | 1 | 3 | 6.1 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/s0960-894x(02)00606-6 | |||
44332684 | 107236 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 474 | 11 | 1 | 3 | 5.7 | O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/s0960-894x(02)00606-6 | |||
CHEMBL316475 | 107236 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 474 | 11 | 1 | 3 | 5.7 | O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/s0960-894x(02)00606-6 | |||
501060 | 108642 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 474 | 10 | 1 | 3 | 5.7 | O=C(O)[C@@H](C1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/s0960-894x(02)00606-6 | |||
CHEMBL320386 | 108642 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 474 | 10 | 1 | 3 | 5.7 | O=C(O)[C@@H](C1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/s0960-894x(02)00606-6 | |||
490018 | 111686 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 568 | 11 | 0 | 6 | 6.1 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(Cc3ccccc3)C[C@@H]2c2ccccc2)CC1 | 10.1021/acs.jmedchem.6b01309 | |||
CHEMBL328445 | 111686 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 568 | 11 | 0 | 6 | 6.1 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(Cc3ccccc3)C[C@@H]2c2ccccc2)CC1 | 10.1021/acs.jmedchem.6b01309 | |||
490018 | 111686 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 568 | 11 | 0 | 6 | 6.1 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(Cc3ccccc3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(01)00545-5 | |||
CHEMBL328445 | 111686 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 568 | 11 | 0 | 6 | 6.1 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(Cc3ccccc3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(01)00545-5 | |||
3002976 | 209735 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 634 | 14 | 0 | 7 | 5.9 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(CC[C@](C)(CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1 | 10.1016/s0960-894x(01)00545-5 | |||
CHEMBL93139 | 209735 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | ChEMBL | 634 | 14 | 0 | 7 | 5.9 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(CC[C@](C)(CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1 | 10.1016/s0960-894x(01)00545-5 | |||
44373756 | 50634 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 588 | 9 | 0 | 7 | 6.3 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN3OC4(CCCCC4)C[C@H]3[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(01)00835-6 | |||
CHEMBL157491 | 50634 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 588 | 9 | 0 | 7 | 6.3 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN3OC4(CCCCC4)C[C@H]3[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(01)00835-6 | |||
11988311 | 179444 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 451 | 8 | 1 | 5 | 5.2 | Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CCCC2)c2ccccc2)CC1 | 10.1016/j.bmcl.2009.01.008 | |||
CHEMBL473558 | 179444 | None | 0 | Human | Binding | pIC50 | = | 9.9 | 9.9 | - | 0 | ChEMBL | 451 | 8 | 1 | 5 | 5.2 | Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CCCC2)c2ccccc2)CC1 | 10.1016/j.bmcl.2009.01.008 | |||
44590750 | 177001 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 490 | 10 | 2 | 3 | 5.1 | CCN(C(=O)NCc1ccccc1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 | 10.1016/j.bmcl.2009.01.009 | |||
CHEMBL461687 | 177001 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 490 | 10 | 2 | 3 | 5.1 | CCN(C(=O)NCc1ccccc1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 | 10.1016/j.bmcl.2009.01.009 | |||
71451877 | 82603 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 638 | 11 | 0 | 6 | 5.0 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cc(F)cc(F)c2)C2CCC(S(C)(=O)=O)CC2)CC1 | 10.1021/jm300682j | |||
CHEMBL2178577 | 82603 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | ChEMBL | 638 | 11 | 0 | 6 | 5.0 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cc(F)cc(F)c2)C2CCC(S(C)(=O)=O)CC2)CC1 | 10.1021/jm300682j | |||
44274043 | 76582 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 542 | 11 | 1 | 3 | 6.8 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
CHEMBL20622 | 76582 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 542 | 11 | 1 | 3 | 6.8 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
44273830 | 79641 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 574 | 11 | 1 | 3 | 7.2 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccc(C(F)(F)F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
CHEMBL21147 | 79641 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 574 | 11 | 1 | 3 | 7.2 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccc(C(F)(F)F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
3002977 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.7 | 9.7 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmcl.2009.01.008 | |||
3002977 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.7 | 9.7 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmcl.2009.01.009 | |||
3002977.0 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.7 | 9.7 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmcl.2009.01.008 | |||
3002977.0 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.7 | 9.7 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmcl.2009.01.009 | |||
803 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.7 | 9.7 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmcl.2009.01.008 | |||
803 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.7 | 9.7 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmcl.2009.01.009 | |||
806 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.7 | 9.7 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmcl.2009.01.008 | |||
806 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.7 | 9.7 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmcl.2009.01.009 | |||
CHEMBL1201187 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.7 | 9.7 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmcl.2009.01.008 | |||
CHEMBL1201187 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.7 | 9.7 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmcl.2009.01.009 | |||
CHEMBL256907 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.7 | 9.7 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmcl.2009.01.008 | |||
CHEMBL256907 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.7 | 9.7 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmcl.2009.01.009 | |||
CHEMBL584744 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.7 | 9.7 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmcl.2009.01.008 | |||
CHEMBL584744 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.7 | 9.7 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmcl.2009.01.009 | |||
DB04835 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.7 | 9.7 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmcl.2009.01.008 | |||
DB04835 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.7 | 9.7 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1016/j.bmcl.2009.01.009 | |||
10414981 | 108197 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 542 | 10 | 2 | 6 | 5.3 | OC1(CCCc2ccc(-c3nnn[nH]3)cc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00605-4 | |||
CHEMBL319593 | 108197 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 542 | 10 | 2 | 6 | 5.3 | OC1(CCCc2ccc(-c3nnn[nH]3)cc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00605-4 | |||
44332341 | 109708 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 556 | 10 | 1 | 7 | 5.3 | Cn1nnnc1-c1ccc(CCCC2(O)CCN(C[C@H]3CN(CC4CCCCC4)C[C@@H]3c3ccccc3)CC2)cc1 | 10.1016/s0960-894x(02)00605-4 | |||
CHEMBL322422 | 109708 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 556 | 10 | 1 | 7 | 5.3 | Cn1nnnc1-c1ccc(CCCC2(O)CCN(C[C@H]3CN(CC4CCCCC4)C[C@@H]3c3ccccc3)CC2)cc1 | 10.1016/s0960-894x(02)00605-4 | |||
44274043 | 76582 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 542 | 11 | 1 | 3 | 6.8 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL20622 | 76582 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 542 | 11 | 1 | 3 | 6.8 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
44273830 | 79641 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 574 | 11 | 1 | 3 | 7.2 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccc(C(F)(F)F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL21147 | 79641 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 574 | 11 | 1 | 3 | 7.2 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccc(C(F)(F)F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
10414981 | 108197 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 542 | 10 | 2 | 6 | 5.3 | OC1(CCCc2ccc(-c3nnn[nH]3)cc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL319593 | 108197 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 542 | 10 | 2 | 6 | 5.3 | OC1(CCCc2ccc(-c3nnn[nH]3)cc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/j.ejmech.2008.01.040 | |||
501063 | 210891 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 488 | 10 | 1 | 3 | 6.1 | O=C(O)[C@@H](C1CCCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL99909 | 210891 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 488 | 10 | 1 | 3 | 6.1 | O=C(O)[C@@H](C1CCCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
10414981 | 108197 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 542 | 10 | 2 | 6 | 5.3 | OC1(CCCc2ccc(-c3nnn[nH]3)cc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00606-6 | |||
CHEMBL319593 | 108197 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 542 | 10 | 2 | 6 | 5.3 | OC1(CCCc2ccc(-c3nnn[nH]3)cc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00606-6 | |||
501063 | 210891 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 488 | 10 | 1 | 3 | 6.1 | O=C(O)[C@@H](C1CCCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/s0960-894x(02)00606-6 | |||
CHEMBL99909 | 210891 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 488 | 10 | 1 | 3 | 6.1 | O=C(O)[C@@H](C1CCCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/s0960-894x(02)00606-6 | |||
501055 | 4615 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 502 | 10 | 1 | 3 | 6.5 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2003.12.004 | |||
CHEMBL102826 | 4615 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 502 | 10 | 1 | 3 | 6.5 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2003.12.004 | |||
516310 | 59629 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 642 | 12 | 1 | 6 | 7.1 | CCn1nc(Cc2ccc(OC3CC3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL171958 | 59629 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 642 | 12 | 1 | 6 | 7.1 | CCn1nc(Cc2ccc(OC3CC3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516257 | 60003 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 610 | 11 | 1 | 5 | 7.2 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc5ccccc5c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL173400 | 60003 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 610 | 11 | 1 | 5 | 7.2 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc5ccccc5c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516288 | 60418 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 610 | 9 | 1 | 5 | 7.2 | CCn1nc(Cc2cccc3ccccc23)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL174927 | 60418 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 610 | 9 | 1 | 5 | 7.2 | CCn1nc(Cc2cccc3ccccc23)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516256 | 128714 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 610 | 11 | 1 | 5 | 7.2 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4cccc5ccccc45)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL366770 | 128714 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 610 | 11 | 1 | 5 | 7.2 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4cccc5ccccc45)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516289 | 131614 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 610 | 9 | 1 | 5 | 7.2 | CCn1nc(Cc2ccc3ccccc3c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL369235 | 131614 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 610 | 9 | 1 | 5 | 7.2 | CCn1nc(Cc2ccc3ccccc3c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
490023 | 112574 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 574 | 10 | 0 | 6 | 5.6 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(01)00545-5 | |||
CHEMBL329893 | 112574 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 574 | 10 | 0 | 6 | 5.6 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(01)00545-5 | |||
490019 | 168081 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 582 | 10 | 0 | 6 | 5.7 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)c3ccccc3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(01)00545-5 | |||
CHEMBL431852 | 168081 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 582 | 10 | 0 | 6 | 5.7 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)c3ccccc3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(01)00545-5 | |||
9916998 | 80017 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 614 | 11 | 0 | 6 | 4.7 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2006.03.089 | |||
CHEMBL212731 | 80017 | None | 0 | Human | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 614 | 11 | 0 | 6 | 4.7 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2006.03.089 | |||
3010274 | 189332 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 543 | 10 | 1 | 5 | 6.3 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL511493 | 189332 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 543 | 10 | 1 | 5 | 6.3 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
3010273 | 192065 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 529 | 10 | 1 | 5 | 5.9 | O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL520091 | 192065 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 529 | 10 | 1 | 5 | 5.9 | O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
44342962 | 111280 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 529 | 10 | 1 | 5 | 5.9 | O=C(O)C(CC1CC1)N1CC(c2ccccc2)[C@@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)C1 | 10.1016/j.bmcl.2004.04.078 | |||
CHEMBL326487 | 111280 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 529 | 10 | 1 | 5 | 5.9 | O=C(O)C(CC1CC1)N1CC(c2ccccc2)[C@@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)C1 | 10.1016/j.bmcl.2004.04.078 | |||
44342961 | 114599 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 543 | 10 | 1 | 5 | 6.3 | O=C(O)C(CC1CCC1)N1CC(c2ccccc2)[C@@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)C1 | 10.1016/j.bmcl.2004.04.078 | |||
CHEMBL333619 | 114599 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 543 | 10 | 1 | 5 | 6.3 | O=C(O)C(CC1CCC1)N1CC(c2ccccc2)[C@@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)C1 | 10.1016/j.bmcl.2004.04.078 | |||
3010274 | 189332 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 543 | 10 | 1 | 5 | 6.3 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL511493 | 189332 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 543 | 10 | 1 | 5 | 6.3 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
3010273 | 192065 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 529 | 10 | 1 | 5 | 5.9 | O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL520091 | 192065 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 529 | 10 | 1 | 5 | 5.9 | O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
11285792 | 879 | None | 32 | Mouse | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1016/j.ejmech.2018.01.085 | |||
801 | 879 | None | 32 | Mouse | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1016/j.ejmech.2018.01.085 | |||
CHEMBL2110727 | 879 | None | 32 | Mouse | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1016/j.ejmech.2018.01.085 | |||
DB11758 | 879 | None | 32 | Mouse | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 696 | 17 | 1 | 7 | 8.7 | CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC | 10.1016/j.ejmech.2018.01.085 | |||
11614352 | 550 | None | 1 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 639 | 11 | 0 | 6 | 4.1 | CCN(C(=O)Cc1ccc(cc1)S(=O)(=O)C)C1CCN(CC1)CC[C@@H](c1cc(F)cc(c1)F)C1CCN(CC1)S(=O)(=O)C | 10.1016/j.bmcl.2011.12.117 | |||
7686 | 550 | None | 1 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 639 | 11 | 0 | 6 | 4.1 | CCN(C(=O)Cc1ccc(cc1)S(=O)(=O)C)C1CCN(CC1)CC[C@@H](c1cc(F)cc(c1)F)C1CCN(CC1)S(=O)(=O)C | 10.1016/j.bmcl.2011.12.117 | |||
CHEMBL1951914 | 550 | None | 1 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 639 | 11 | 0 | 6 | 4.1 | CCN(C(=O)Cc1ccc(cc1)S(=O)(=O)C)C1CCN(CC1)CC[C@@H](c1cc(F)cc(c1)F)C1CCN(CC1)S(=O)(=O)C | 10.1016/j.bmcl.2011.12.117 | |||
3010264 | 183909 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 557 | 9 | 1 | 5 | 6.7 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL480503 | 183909 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 557 | 9 | 1 | 5 | 6.7 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
3010264 | 183909 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 557 | 9 | 1 | 5 | 6.7 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL480503 | 183909 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 557 | 9 | 1 | 5 | 6.7 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
3010264 | 183909 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 557 | 9 | 1 | 5 | 6.7 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2004.04.078 | |||
CHEMBL480503 | 183909 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 557 | 9 | 1 | 5 | 6.7 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2004.04.078 | |||
10347790 | 78490 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 560 | 11 | 1 | 3 | 6.9 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL21117 | 78490 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 560 | 11 | 1 | 3 | 6.9 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
44565720 | 174433 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 570 | 11 | 1 | 3 | 7.5 | O=C(O)[C@@H](CC1CCCCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL455073 | 174433 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 570 | 11 | 1 | 3 | 7.5 | O=C(O)[C@@H](CC1CCCCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
20672370 | 78062 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 531 | 11 | 1 | 4 | 6.1 | N#Cc1ccc(CCCC2CCN(C[C@H]3CN([C@H](CC4CCC4)C(=O)O)C[C@@H]3c3cccc(F)c3)CC2)cc1 | 10.1016/s0960-894x(02)00829-6 | |||
CHEMBL20988 | 78062 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 531 | 11 | 1 | 4 | 6.1 | N#Cc1ccc(CCCC2CCN(C[C@H]3CN([C@H](CC4CCC4)C(=O)O)C[C@@H]3c3cccc(F)c3)CC2)cc1 | 10.1016/s0960-894x(02)00829-6 | |||
10347790 | 78490 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 560 | 11 | 1 | 3 | 6.9 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
CHEMBL21117 | 78490 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 560 | 11 | 1 | 3 | 6.9 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
20672362 | 99490 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 556 | 10 | 1 | 3 | 7.2 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
CHEMBL282921 | 99490 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 556 | 10 | 1 | 3 | 7.2 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
10369469 | 70373 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 522 | 8 | 1 | 5 | 5.2 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccc(F)cn34)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2005.02.030 | |||
CHEMBL194497 | 70373 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 522 | 8 | 1 | 5 | 5.2 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccc(F)cn34)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2005.02.030 | |||
489315 | 107416 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 474 | 9 | 1 | 3 | 6.1 | OC1(CCCc2ccccc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00605-4 | |||
CHEMBL317710 | 107416 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 474 | 9 | 1 | 3 | 6.1 | OC1(CCCc2ccccc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00605-4 | |||
10347790 | 78490 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 560 | 11 | 1 | 3 | 6.9 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL21117 | 78490 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 560 | 11 | 1 | 3 | 6.9 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
44565720 | 174433 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 570 | 11 | 1 | 3 | 7.5 | O=C(O)[C@@H](CC1CCCCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL455073 | 174433 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 570 | 11 | 1 | 3 | 7.5 | O=C(O)[C@@H](CC1CCCCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
72712598 | 92692 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 591 | 5 | 0 | 4 | 6.6 | Cc1cc(Cl)nc(C)c1C(=O)N1CCC(C)(N2CCC(N3C(=O)N(C4CCCCC4)C[C@H]3c3ccccc3)CC2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435848 | 92692 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 591 | 5 | 0 | 4 | 6.6 | Cc1cc(Cl)nc(C)c1C(=O)N1CCC(C)(N2CCC(N3C(=O)N(C4CCCCC4)C[C@H]3c3ccccc3)CC2)CC1 | 10.1021/jm401101p | |||
516231 | 59873 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 610 | 11 | 1 | 5 | 7.2 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc5ccccc5c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL172894 | 59873 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 610 | 11 | 1 | 5 | 7.2 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc5ccccc5c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516245 | 59880 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 616 | 13 | 1 | 6 | 6.6 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC5CC5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL172916 | 59880 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 616 | 13 | 1 | 6 | 6.6 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC5CC5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516235 | 60237 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 636 | 12 | 1 | 5 | 7.7 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(-c5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL174004 | 60237 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 636 | 12 | 1 | 5 | 7.7 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(-c5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516224 | 61675 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 626 | 13 | 1 | 6 | 6.6 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL177127 | 61675 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 626 | 13 | 1 | 6 | 6.6 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516234 | 99054 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 616 | 11 | 1 | 5 | 7.3 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C(C)(C)C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL279992 | 99054 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 616 | 11 | 1 | 5 | 7.3 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C(C)(C)C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516233 | 128747 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 602 | 12 | 1 | 5 | 7.2 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C(C)C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL366868 | 128747 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 602 | 12 | 1 | 5 | 7.2 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C(C)C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516202 | 130349 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 622 | 11 | 1 | 5 | 7.3 | CCn1nc(Cc2ccc(-c3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL367987 | 130349 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 622 | 11 | 1 | 5 | 7.3 | CCn1nc(Cc2ccc(-c3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516314 | 130751 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 662 | 11 | 1 | 5 | 8.2 | CCn1nc(Cc2ccc(-c3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL368329 | 130751 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 662 | 11 | 1 | 5 | 8.2 | CCn1nc(Cc2ccc(-c3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516216 | 131505 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 616 | 13 | 1 | 6 | 6.6 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC5CC5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL369059 | 131505 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 616 | 13 | 1 | 6 | 6.6 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC5CC5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516262 | 166459 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 628 | 9 | 1 | 5 | 7.0 | CCn1nc(Cc2ccc(C(F)(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL427493 | 166459 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 628 | 9 | 1 | 5 | 7.0 | CCn1nc(Cc2ccc(C(F)(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516232 | 168634 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 574 | 11 | 1 | 5 | 6.3 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL435472 | 168634 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 574 | 11 | 1 | 5 | 6.3 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL181276 | 211440 | None | 44 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | None | None | None | C[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(N)=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O | 10.1016/j.ejmech.2020.112819 | |||||
16007088 | 80007 | None | 24 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 632 | 11 | 0 | 6 | 4.8 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cc(F)cc(F)c2)CC1 | 10.1021/jm300682j | |||
CHEMBL212689 | 80007 | None | 24 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 632 | 11 | 0 | 6 | 4.8 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cc(F)cc(F)c2)CC1 | 10.1021/jm300682j | |||
16007088 | 80007 | None | 24 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 632 | 11 | 0 | 6 | 4.8 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cc(F)cc(F)c2)CC1 | 10.1016/j.bmcl.2006.03.089 | |||
CHEMBL212689 | 80007 | None | 24 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 632 | 11 | 0 | 6 | 4.8 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cc(F)cc(F)c2)CC1 | 10.1016/j.bmcl.2006.03.089 | |||
16007088 | 80007 | None | 24 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 632 | 11 | 0 | 6 | 4.8 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cc(F)cc(F)c2)CC1 | 10.1016/j.bmcl.2011.12.117 | |||
CHEMBL212689 | 80007 | None | 24 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 632 | 11 | 0 | 6 | 4.8 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cc(F)cc(F)c2)CC1 | 10.1016/j.bmcl.2011.12.117 | |||
3010271 | 183948 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 527 | 10 | 1 | 5 | 5.8 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)o3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL480693 | 183948 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 527 | 10 | 1 | 5 | 5.8 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)o3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
44590633 | 176308 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 509 | 10 | 1 | 3 | 5.6 | CCN(C(=O)Cc1ccc(Cl)cc1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 | 10.1016/j.bmcl.2009.01.009 | |||
CHEMBL459384 | 176308 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 509 | 10 | 1 | 3 | 5.6 | CCN(C(=O)Cc1ccc(Cl)cc1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 | 10.1016/j.bmcl.2009.01.009 | |||
3010271 | 183948 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 527 | 10 | 1 | 5 | 5.8 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)o3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL480693 | 183948 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 527 | 10 | 1 | 5 | 5.8 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)o3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
3010271 | 183948 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 527 | 10 | 1 | 5 | 5.8 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)o3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2004.04.078 | |||
CHEMBL480693 | 183948 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 527 | 10 | 1 | 5 | 5.8 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)o3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2004.04.078 | |||
44401488 | 70099 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 532 | 9 | 1 | 5 | 5.6 | CCc1ccn2c(C3CCN(C[C@H]4CN([C@H](CC5CCC5)C(=O)O)C[C@@H]4c4cccc(F)c4)CC3)cnc2c1 | 10.1016/j.bmcl.2005.02.030 | |||
CHEMBL193984 | 70099 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 532 | 9 | 1 | 5 | 5.6 | CCc1ccn2c(C3CCN(C[C@H]4CN([C@H](CC5CCC5)C(=O)O)C[C@@H]4c4cccc(F)c4)CC3)cnc2c1 | 10.1016/j.bmcl.2005.02.030 | |||
53260398 | 62883 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 512 | 5 | 0 | 4 | 6.5 | Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CCC1(c2ccccc2)CCN(C(=O)C(C)(C)C)CC1 | 10.1021/jm200279v | |||
CHEMBL1784385 | 62883 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 512 | 5 | 0 | 4 | 6.5 | Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CCC1(c2ccccc2)CCN(C(=O)C(C)(C)C)CC1 | 10.1021/jm200279v | |||
3002977 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/ml400370w | |||
3002977.0 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/ml400370w | |||
803 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/ml400370w | |||
806 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/ml400370w | |||
CHEMBL1201187 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/ml400370w | |||
CHEMBL256907 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/ml400370w | |||
CHEMBL584744 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/ml400370w | |||
DB04835 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/ml400370w | |||
44565038 | 186964 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 473 | 8 | 1 | 5 | 5.0 | Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CC(F)(F)C2)c2ccccc2)CC1 | 10.1016/j.bmcl.2009.01.008 | |||
CHEMBL489513 | 186964 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 473 | 8 | 1 | 5 | 5.0 | Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CC(F)(F)C2)c2ccccc2)CC1 | 10.1016/j.bmcl.2009.01.008 | |||
CHEMBL491679 | 186964 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 473 | 8 | 1 | 5 | 5.0 | Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CC(F)(F)C2)c2ccccc2)CC1 | 10.1016/j.bmcl.2009.01.008 | |||
3010268 | 78751 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 526 | 10 | 2 | 4 | 5.5 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3c[nH]c(Cc4ccccc4)n3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2004.04.078 | |||
CHEMBL2112559 | 78751 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 526 | 10 | 2 | 4 | 5.5 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3c[nH]c(Cc4ccccc4)n3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2004.04.078 | |||
44273996 | 75588 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 526 | 11 | 2 | 4 | 5.5 | O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL20453 | 75588 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 526 | 11 | 2 | 4 | 5.5 | O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
44565673 | 177746 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 556 | 10 | 1 | 7 | 5.3 | Cn1nnc(-c2ccc(CCCC3(O)CCN(C[C@H]4CN(CC5CCCCC5)C[C@@H]4c4ccccc4)CC3)cc2)n1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL464132 | 177746 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 556 | 10 | 1 | 7 | 5.3 | Cn1nnc(-c2ccc(CCCC3(O)CCN(C[C@H]4CN(CC5CCCCC5)C[C@@H]4c4ccccc4)CC3)cc2)n1 | 10.1016/j.ejmech.2008.01.040 | |||
44273996 | 75588 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 526 | 11 | 2 | 4 | 5.5 | O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
CHEMBL20453 | 75588 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 526 | 11 | 2 | 4 | 5.5 | O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
44273888 | 98822 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 558 | 11 | 1 | 4 | 5.5 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CC[S+]([O-])c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
CHEMBL278117 | 98822 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 558 | 11 | 1 | 4 | 5.5 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CC[S+]([O-])c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
44357079 | 119405 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 541 | 11 | 1 | 6 | 4.8 | CCCN(c1ncc(F)cn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL344261 | 119405 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 541 | 11 | 1 | 6 | 4.8 | CCCN(c1ncc(F)cn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
3001322 | 443 | None | 22 | Mouse | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.ejmech.2018.01.085 | |||
805 | 443 | None | 22 | Mouse | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.ejmech.2018.01.085 | |||
CHEMBL1255794 | 443 | None | 22 | Mouse | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.ejmech.2018.01.085 | |||
DB06497 | 443 | None | 22 | Mouse | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.ejmech.2018.01.085 | |||
44332489 | 4756 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 557 | 10 | 2 | 5 | 4.7 | C[n+]1n[nH]c(-c2ccc(CCCC3(O)CCN(C[C@H]4CN(CC5CCCCC5)C[C@@H]4c4ccccc4)CC3)cc2)n1 | 10.1016/s0960-894x(02)00605-4 | |||
CHEMBL103790 | 4756 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 557 | 10 | 2 | 5 | 4.7 | C[n+]1n[nH]c(-c2ccc(CCCC3(O)CCN(C[C@H]4CN(CC5CCCCC5)C[C@@H]4c4ccccc4)CC3)cc2)n1 | 10.1016/s0960-894x(02)00605-4 | |||
44273996 | 75588 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 526 | 11 | 2 | 4 | 5.5 | O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL20453 | 75588 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 526 | 11 | 2 | 4 | 5.5 | O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
44565673 | 177746 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 556 | 10 | 1 | 7 | 5.3 | Cn1nnc(-c2ccc(CCCC3(O)CCN(C[C@H]4CN(CC5CCCCC5)C[C@@H]4c4ccccc4)CC3)cc2)n1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL464132 | 177746 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 556 | 10 | 1 | 7 | 5.3 | Cn1nnc(-c2ccc(CCCC3(O)CCN(C[C@H]4CN(CC5CCCCC5)C[C@@H]4c4ccccc4)CC3)cc2)n1 | 10.1016/j.ejmech.2008.01.040 | |||
58834969 | 92701 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 586 | 8 | 1 | 6 | 5.9 | Cc1nc(Sc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435857 | 92701 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 586 | 8 | 1 | 6 | 5.9 | Cc1nc(Sc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
516292 | 60298 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 616 | 9 | 1 | 5 | 7.3 | CCn1nc(Cc2ccc(C(C)(C)C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL174214 | 60298 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 616 | 9 | 1 | 5 | 7.3 | CCn1nc(Cc2ccc(C(C)(C)C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516201 | 60483 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 608 | 12 | 1 | 6 | 6.2 | CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1F | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL175348 | 60483 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 608 | 12 | 1 | 6 | 6.2 | CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1F | 10.1016/j.bmcl.2003.12.006 | |||
516246 | 61092 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 630 | 13 | 1 | 6 | 7.0 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC5CCC5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL176459 | 61092 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 630 | 13 | 1 | 6 | 7.0 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC5CCC5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516255 | 61302 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 622 | 13 | 1 | 6 | 6.6 | CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1F | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL176669 | 61302 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 622 | 13 | 1 | 6 | 6.6 | CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1F | 10.1016/j.bmcl.2003.12.006 | |||
516279 | 96532 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 652 | 11 | 1 | 6 | 7.8 | CCn1nc(Cc2ccc(Oc3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL262402 | 96532 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 652 | 11 | 1 | 6 | 7.8 | CCn1nc(Cc2ccc(Oc3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516230 | 128536 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 610 | 11 | 1 | 5 | 7.2 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4cccc5ccccc45)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL366611 | 128536 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 610 | 11 | 1 | 5 | 7.2 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4cccc5ccccc45)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516274 | 128750 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 616 | 11 | 1 | 6 | 6.6 | CCn1nc(Cc2ccc(OC3CC3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL366873 | 128750 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 616 | 11 | 1 | 6 | 6.6 | CCn1nc(Cc2ccc(OC3CC3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516221 | 132638 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 652 | 13 | 1 | 6 | 7.8 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(Oc5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL369812 | 132638 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 652 | 13 | 1 | 6 | 7.8 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(Oc5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516271 | 168360 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 604 | 11 | 1 | 6 | 6.4 | CCOc1cccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)c1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL433793 | 168360 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 604 | 11 | 1 | 6 | 6.4 | CCOc1cccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)c1 | 10.1016/j.bmcl.2003.12.006 | |||
20664161 | 79039 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 504 | 8 | 1 | 5 | 5.0 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccccn34)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2005.02.030 | |||
CHEMBL2113086 | 79039 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 504 | 8 | 1 | 5 | 5.0 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccccn34)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2005.02.030 | |||
3002977 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/ml400370w | |||
3002977.0 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/ml400370w | |||
803 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/ml400370w | |||
806 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/ml400370w | |||
CHEMBL1201187 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/ml400370w | |||
CHEMBL256907 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/ml400370w | |||
CHEMBL584744 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/ml400370w | |||
DB04835 | 2460 | None | 43 | Human | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 2 | ChEMBL | 513 | 8 | 1 | 5 | 6.0 | O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C | 10.1021/ml400370w | |||
57391721 | 71087 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 617 | 11 | 0 | 6 | 4.1 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cccc(C)c2)C2CCN(S(C)(=O)=O)CC2)CC1 | 10.1016/j.bmcl.2011.12.117 | |||
CHEMBL1951913 | 71087 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 617 | 11 | 0 | 6 | 4.1 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cccc(C)c2)C2CCN(S(C)(=O)=O)CC2)CC1 | 10.1016/j.bmcl.2011.12.117 | |||
3009355 | 3989 | None | 18 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 533 | 6 | 0 | 6 | 4.5 | COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F | 10.1021/jm300682j | |||
807 | 3989 | None | 18 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 533 | 6 | 0 | 6 | 4.5 | COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F | 10.1021/jm300682j | |||
CHEMBL82301 | 3989 | None | 18 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 533 | 6 | 0 | 6 | 4.5 | COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F | 10.1021/jm300682j | |||
DB06652 | 3989 | None | 18 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 1 | ChEMBL | 533 | 6 | 0 | 6 | 4.5 | COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F | 10.1021/jm300682j | |||
44590634 | 174909 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 543 | 10 | 1 | 3 | 6.0 | CCN(C(=O)Cc1ccc(C(F)(F)F)cc1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 | 10.1016/j.bmcl.2009.01.009 | |||
CHEMBL456226 | 174909 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 543 | 10 | 1 | 3 | 6.0 | CCN(C(=O)Cc1ccc(C(F)(F)F)cc1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 | 10.1016/j.bmcl.2009.01.009 | |||
44565080 | 187190 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 473 | 8 | 1 | 5 | 5.0 | Cc1nnc(C(C)C)n1C1CCN([C@H](C)C[C@H](NC(=O)C2CC(F)(F)C2)c2ccccc2)CC1 | 10.1016/j.bmcl.2009.01.008 | |||
CHEMBL491319 | 187190 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 473 | 8 | 1 | 5 | 5.0 | Cc1nnc(C(C)C)n1C1CCN([C@H](C)C[C@H](NC(=O)C2CC(F)(F)C2)c2ccccc2)CC1 | 10.1016/j.bmcl.2009.01.008 | |||
20672360 | 77347 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 534 | 10 | 1 | 3 | 6.4 | CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
CHEMBL20831 | 77347 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 534 | 10 | 1 | 3 | 6.4 | CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
20672386 | 98811 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 506 | 11 | 1 | 3 | 6.2 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
CHEMBL278085 | 98811 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 506 | 11 | 1 | 3 | 6.2 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
44273888 | 98822 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 558 | 11 | 1 | 4 | 5.5 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CC[S+]([O-])c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
CHEMBL278117 | 98822 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 558 | 11 | 1 | 4 | 5.5 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CC[S+]([O-])c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
44590440 | 179310 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 487 | 6 | 0 | 3 | 5.2 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)C(=O)C3CC3)CC2)CC1 | 10.1016/j.bmcl.2009.01.012 | |||
CHEMBL472464 | 179310 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 487 | 6 | 0 | 3 | 5.2 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)C(=O)C3CC3)CC2)CC1 | 10.1016/j.bmcl.2009.01.012 | |||
44357078 | 119465 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 591 | 11 | 1 | 6 | 5.7 | CCCN(c1ncc(C(F)(F)F)cn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL344641 | 119465 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 591 | 11 | 1 | 6 | 5.7 | CCCN(c1ncc(C(F)(F)F)cn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
44401956 | 133647 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 572 | 8 | 1 | 5 | 6.3 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4c(Cl)cc(Cl)cn34)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2005.02.030 | |||
CHEMBL371177 | 133647 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 572 | 8 | 1 | 5 | 6.3 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4c(Cl)cc(Cl)cn34)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2005.02.030 | |||
20672386 | 98811 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 506 | 11 | 1 | 3 | 6.2 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL278085 | 98811 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 506 | 11 | 1 | 3 | 6.2 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
44565742 | 179226 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 548 | 11 | 1 | 3 | 6.8 | CC(C)C[C@H](C(=O)O)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL471920 | 179226 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 548 | 11 | 1 | 3 | 6.8 | CC(C)C[C@H](C(=O)O)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
10163007 | 95151 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 482 | 5 | 0 | 4 | 6.0 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1 | 10.1016/j.bmcl.2008.01.108 | |||
CHEMBL255429 | 95151 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 482 | 5 | 0 | 4 | 6.0 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1 | 10.1016/j.bmcl.2008.01.108 | |||
501046 | 109731 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 518 | 10 | 2 | 4 | 5.6 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(O)(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/s0960-894x(02)00606-6 | |||
CHEMBL322603 | 109731 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 518 | 10 | 2 | 4 | 5.6 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(O)(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/s0960-894x(02)00606-6 | |||
72714079 | 92730 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 565 | 8 | 1 | 4 | 6.1 | Cc1cc(Cl)nc(C)c1C(=O)NCC[C@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435886 | 92730 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 565 | 8 | 1 | 4 | 6.1 | Cc1cc(Cl)nc(C)c1C(=O)NCC[C@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
516311 | 59931 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 658 | 11 | 1 | 6 | 7.7 | CCn1nc(Cc2ccc(OC(C)(C)C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL173091 | 59931 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 658 | 11 | 1 | 6 | 7.7 | CCn1nc(Cc2ccc(OC(C)(C)C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516312 | 60022 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 678 | 12 | 1 | 6 | 8.4 | CCn1nc(Cc2ccc(Oc3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL173479 | 60022 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 678 | 12 | 1 | 6 | 8.4 | CCn1nc(Cc2ccc(Oc3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516192 | 60049 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 618 | 14 | 1 | 6 | 6.8 | CCCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL173583 | 60049 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 618 | 14 | 1 | 6 | 6.8 | CCCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 | 10.1016/j.bmcl.2003.12.006 | |||
516282 | 60425 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 626 | 11 | 1 | 6 | 6.6 | CCn1nc(Cc2ccc(OC(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL174996 | 60425 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 626 | 11 | 1 | 6 | 6.6 | CCn1nc(Cc2ccc(OC(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516228 | 60440 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 615 | 12 | 1 | 7 | 5.9 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC)c(C#N)c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL175079 | 60440 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 615 | 12 | 1 | 7 | 5.9 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC)c(C#N)c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516227 | 60481 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 604 | 11 | 1 | 7 | 5.8 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc5c(c4)OCO5)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL175341 | 60481 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 604 | 11 | 1 | 7 | 5.8 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc5c(c4)OCO5)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516313 | 61152 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 602 | 10 | 2 | 6 | 6.3 | CCn1nc(Cc2ccc(O)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL176528 | 61152 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 602 | 10 | 2 | 6 | 6.3 | CCn1nc(Cc2ccc(O)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
44385583 | 61520 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 578 | 9 | 1 | 5 | 6.2 | CCn1nc(Cc2ccccc2F)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL177071 | 61520 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 578 | 9 | 1 | 5 | 6.2 | CCn1nc(Cc2ccccc2F)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516251 | 96945 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 658 | 13 | 1 | 6 | 7.0 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OCC(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL265723 | 96945 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 658 | 13 | 1 | 6 | 7.0 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OCC(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516205 | 128535 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 628 | 11 | 1 | 5 | 7.0 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL366610 | 128535 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 628 | 11 | 1 | 5 | 7.0 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516259 | 129798 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 636 | 12 | 1 | 5 | 7.7 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(-c5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL367416 | 129798 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 636 | 12 | 1 | 5 | 7.7 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(-c5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
44384782 | 130262 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 589 | 12 | 2 | 6 | 6.1 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4cccc(NC)c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL367897 | 130262 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 589 | 12 | 2 | 6 | 6.1 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4cccc(NC)c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516248 | 130353 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 666 | 14 | 1 | 6 | 7.6 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OCc5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL368000 | 130353 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 666 | 14 | 1 | 6 | 7.6 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OCc5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516198 | 131892 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 612 | 12 | 1 | 6 | 6.2 | CCn1nc(Cc2ccc(OC(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL369398 | 131892 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 612 | 12 | 1 | 6 | 6.2 | CCn1nc(Cc2ccc(OC(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516237 | 131969 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 628 | 11 | 1 | 5 | 7.0 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL369478 | 131969 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 628 | 11 | 1 | 5 | 7.0 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516249 | 132176 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 652 | 13 | 1 | 6 | 7.8 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(Oc5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL369593 | 132176 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 652 | 13 | 1 | 6 | 7.8 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(Oc5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
3010272 | 189561 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 517 | 9 | 1 | 5 | 5.7 | CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL513564 | 189561 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 517 | 9 | 1 | 5 | 5.7 | CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
3010272 | 189561 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 517 | 9 | 1 | 5 | 5.7 | CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2004.04.078 | |||
CHEMBL513564 | 189561 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 517 | 9 | 1 | 5 | 5.7 | CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2004.04.078 | |||
3010272 | 189561 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 517 | 9 | 1 | 5 | 5.7 | CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL513564 | 189561 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 517 | 9 | 1 | 5 | 5.7 | CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
44564930 | 179470 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 465 | 8 | 1 | 5 | 5.6 | Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CCCCC2)c2ccccc2)CC1 | 10.1016/j.bmcl.2009.01.008 | |||
CHEMBL473759 | 179470 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 465 | 8 | 1 | 5 | 5.6 | Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CCCCC2)c2ccccc2)CC1 | 10.1016/j.bmcl.2009.01.008 | |||
57391722 | 71089 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 637 | 11 | 0 | 6 | 4.4 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cccc(Cl)c2)C2CCN(S(C)(=O)=O)CC2)CC1 | 10.1016/j.bmcl.2011.12.117 | |||
CHEMBL1951917 | 71089 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 637 | 11 | 0 | 6 | 4.4 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cccc(Cl)c2)C2CCN(S(C)(=O)=O)CC2)CC1 | 10.1016/j.bmcl.2011.12.117 | |||
44565761 | 188424 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 554 | 11 | 2 | 4 | 6.1 | CCc1nc(Cc2ccccc2)[nH]c1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL500631 | 188424 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 554 | 11 | 2 | 4 | 6.1 | CCc1nc(Cc2ccccc2)[nH]c1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1 | 10.1016/j.ejmech.2008.01.040 | |||
3010275 | 78750 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 572 | 11 | 2 | 4 | 6.2 | CCc1[nH]c(Cc2ccccc2)nc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2004.04.078 | |||
CHEMBL2112558 | 78750 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 572 | 11 | 2 | 4 | 6.2 | CCc1[nH]c(Cc2ccccc2)nc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2004.04.078 | |||
44565761 | 188424 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 554 | 11 | 2 | 4 | 6.1 | CCc1nc(Cc2ccccc2)[nH]c1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL500631 | 188424 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 554 | 11 | 2 | 4 | 6.1 | CCc1nc(Cc2ccccc2)[nH]c1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1 | 10.1016/j.ejmech.2008.01.040 | |||
44565762 | 179301 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 560 | 10 | 2 | 4 | 6.2 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3[nH]c(Cc4ccccc4)nc3Cl)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL472412 | 179301 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 560 | 10 | 2 | 4 | 6.2 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3[nH]c(Cc4ccccc4)nc3Cl)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
44401965 | 71342 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 549 | 9 | 1 | 7 | 4.9 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccc([N+](=O)[O-])cn34)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2005.02.030 | |||
CHEMBL195753 | 71342 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 549 | 9 | 1 | 7 | 4.9 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccc([N+](=O)[O-])cn34)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2005.02.030 | |||
44565762 | 179301 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 560 | 10 | 2 | 4 | 6.2 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3[nH]c(Cc4ccccc4)nc3Cl)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL472412 | 179301 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 560 | 10 | 2 | 4 | 6.2 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3[nH]c(Cc4ccccc4)nc3Cl)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
3008904 | 202422 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 537 | 6 | 0 | 5 | 5.0 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3cccc(C#N)c3)c3ccccc3)CC2)CC1 | 10.1016/j.bmcl.2008.01.108 | |||
CHEMBL59511 | 202422 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 537 | 6 | 0 | 5 | 5.0 | Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3cccc(C#N)c3)c3ccccc3)CC2)CC1 | 10.1016/j.bmcl.2008.01.108 | |||
58834906 | 92697 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 604 | 8 | 1 | 6 | 6.2 | Cc1nc(Oc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2cccc(Cl)c2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435853 | 92697 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 604 | 8 | 1 | 6 | 6.2 | Cc1nc(Oc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2cccc(Cl)c2)CC1 | 10.1021/jm401101p | |||
3010276 | 78749 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 578 | 10 | 2 | 4 | 6.3 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3[nH]c(Cc4ccccc4)nc3Cl)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2004.04.078 | |||
CHEMBL2112557 | 78749 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 578 | 10 | 2 | 4 | 6.3 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3[nH]c(Cc4ccccc4)nc3Cl)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2004.04.078 | |||
516337 | 130247 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 596 | 12 | 1 | 5 | 7.0 | CCCn1ncc(CCc2ccccc2)c1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/j.bmcl.2003.12.004 | |||
CHEMBL367837 | 130247 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 596 | 12 | 1 | 5 | 7.0 | CCCn1ncc(CCc2ccccc2)c1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/j.bmcl.2003.12.004 | |||
516333 | 120404 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 582 | 11 | 1 | 5 | 6.6 | CCn1ncc(CCc2ccccc2)c1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/j.bmcl.2003.12.004 | |||
CHEMBL352981 | 120404 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 582 | 11 | 1 | 5 | 6.6 | CCn1ncc(CCc2ccccc2)c1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/j.bmcl.2003.12.004 | |||
516293 | 59716 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 636 | 10 | 1 | 5 | 7.7 | CCn1nc(Cc2ccc(-c3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL172296 | 59716 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 636 | 10 | 1 | 5 | 7.7 | CCn1nc(Cc2ccc(-c3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516194 | 59970 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 616 | 12 | 1 | 6 | 6.6 | CCn1nc(Cc2ccc(OC3CCC3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL173254 | 59970 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 616 | 12 | 1 | 6 | 6.6 | CCn1nc(Cc2ccc(OC3CCC3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516280 | 61087 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 644 | 10 | 1 | 6 | 6.9 | CCn1nc(Cc2ccc(OC(F)(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL176426 | 61087 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 644 | 10 | 1 | 6 | 6.9 | CCn1nc(Cc2ccc(OC(F)(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516223 | 61398 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 658 | 13 | 1 | 6 | 7.0 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OCC(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL176933 | 61398 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 658 | 13 | 1 | 6 | 7.0 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OCC(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516199 | 96569 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 562 | 10 | 2 | 6 | 5.3 | CCn1nc(Cc2ccc(O)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL262663 | 96569 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 562 | 10 | 2 | 6 | 5.3 | CCn1nc(Cc2ccc(O)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516291 | 96690 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 602 | 10 | 1 | 5 | 7.2 | CCn1nc(Cc2ccc(C(C)C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL263529 | 96690 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 602 | 10 | 1 | 5 | 7.2 | CCn1nc(Cc2ccc(C(C)C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516252 | 129888 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 626 | 13 | 1 | 6 | 6.6 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL367560 | 129888 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 626 | 13 | 1 | 6 | 6.6 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516212 | 130152 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 604 | 13 | 1 | 6 | 6.4 | CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL367700 | 130152 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 604 | 13 | 1 | 6 | 6.4 | CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 | 10.1016/j.bmcl.2003.12.006 | |||
516209 | 130782 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 700 | 13 | 1 | 7 | 6.9 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(S(=O)(=O)c5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL368467 | 130782 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 700 | 13 | 1 | 7 | 6.9 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(S(=O)(=O)c5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516290 | 131997 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 574 | 9 | 1 | 5 | 6.3 | CCn1nc(Cc2ccc(C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL369494 | 131997 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 574 | 9 | 1 | 5 | 6.3 | CCn1nc(Cc2ccc(C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516250 | 132200 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 644 | 12 | 1 | 6 | 6.9 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL369659 | 132200 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 644 | 12 | 1 | 6 | 6.9 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516253 | 158300 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 576 | 11 | 2 | 6 | 5.7 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(O)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL408800 | 158300 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 576 | 11 | 2 | 6 | 5.7 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(O)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516196 | 166177 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 638 | 12 | 1 | 6 | 7.4 | CCn1nc(Cc2ccc(Oc3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL425845 | 166177 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 638 | 12 | 1 | 6 | 7.4 | CCn1nc(Cc2ccc(Oc3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516281 | 166393 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 658 | 11 | 1 | 6 | 7.0 | CCn1nc(Cc2ccc(OCC(F)(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL427122 | 166393 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 658 | 11 | 1 | 6 | 7.0 | CCn1nc(Cc2ccc(OCC(F)(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
3010261 | 192492 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 540 | 9 | 2 | 4 | 5.9 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)[nH]3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL520755 | 192492 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 540 | 9 | 2 | 4 | 5.9 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)[nH]3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
3010261 | 192492 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 540 | 9 | 2 | 4 | 5.9 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)[nH]3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL520755 | 192492 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 540 | 9 | 2 | 4 | 5.9 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)[nH]3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
3010261 | 192492 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 540 | 9 | 2 | 4 | 5.9 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)[nH]3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2004.04.078 | |||
CHEMBL520755 | 192492 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 540 | 9 | 2 | 4 | 5.9 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)[nH]3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2004.04.078 | |||
57403932 | 71086 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 621 | 11 | 0 | 6 | 3.9 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cccc(F)c2)C2CCN(S(C)(=O)=O)CC2)CC1 | 10.1016/j.bmcl.2011.12.117 | |||
CHEMBL1951912 | 71086 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 621 | 11 | 0 | 6 | 3.9 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cccc(F)c2)C2CCN(S(C)(=O)=O)CC2)CC1 | 10.1016/j.bmcl.2011.12.117 | |||
57396952 | 71088 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 655 | 11 | 0 | 6 | 4.6 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cc(F)cc(Cl)c2)C2CCN(S(C)(=O)=O)CC2)CC1 | 10.1016/j.bmcl.2011.12.117 | |||
CHEMBL1951915 | 71088 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 655 | 11 | 0 | 6 | 4.6 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cc(F)cc(Cl)c2)C2CCN(S(C)(=O)=O)CC2)CC1 | 10.1016/j.bmcl.2011.12.117 | |||
501056 | 107528 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 462 | 10 | 1 | 3 | 5.5 | CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL318406 | 107528 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 462 | 10 | 1 | 3 | 5.5 | CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
501056 | 107528 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 462 | 10 | 1 | 3 | 5.5 | CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL318406 | 107528 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 462 | 10 | 1 | 3 | 5.5 | CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
3008917 | 205241 | None | 3 | Crab-eating macaque | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 481 | 5 | 0 | 3 | 6.6 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1016/j.bmcl.2008.01.108 | |||
CHEMBL62152 | 205241 | None | 3 | Crab-eating macaque | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 481 | 5 | 0 | 3 | 6.6 | Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 | 10.1016/j.bmcl.2008.01.108 | |||
501056 | 107528 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 462 | 10 | 1 | 3 | 5.5 | CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/s0960-894x(02)00606-6 | |||
CHEMBL318406 | 107528 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 462 | 10 | 1 | 3 | 5.5 | CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/s0960-894x(02)00606-6 | |||
58835217 | 92700 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 584 | 9 | 1 | 6 | 5.8 | CCc1nc(Oc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435856 | 92700 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 584 | 9 | 1 | 6 | 5.8 | CCc1nc(Oc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
44415755 | 138786 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 451 | 9 | 2 | 3 | 4.0 | O=C(Cc1ccc(F)cc1)NC1CCN(CC[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 | 10.1016/j.bmcl.2006.06.012 | |||
CHEMBL377914 | 138786 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 451 | 9 | 2 | 3 | 4.0 | O=C(Cc1ccc(F)cc1)NC1CCN(CC[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 | 10.1016/j.bmcl.2006.06.012 | |||
3010279 | 78744 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 564 | 10 | 2 | 4 | 5.9 | O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(c3[nH]c(Cc4ccccc4)nc3Cl)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2004.04.078 | |||
CHEMBL2112552 | 78744 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 564 | 10 | 2 | 4 | 5.9 | O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(c3[nH]c(Cc4ccccc4)nc3Cl)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2004.04.078 | |||
516285 | 59724 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 604 | 9 | 1 | 7 | 5.8 | CCn1nc(Cc2ccc3c(c2)OCO3)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL172322 | 59724 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 604 | 9 | 1 | 7 | 5.8 | CCn1nc(Cc2ccc3c(c2)OCO3)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516229 | 59983 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 622 | 13 | 1 | 6 | 6.6 | CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1F | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL173308 | 59983 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 622 | 13 | 1 | 6 | 6.6 | CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1F | 10.1016/j.bmcl.2003.12.006 | |||
516308 | 60488 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 644 | 13 | 1 | 6 | 7.4 | CCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C5CCCCC5)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL175394 | 60488 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 644 | 13 | 1 | 6 | 7.4 | CCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C5CCCCC5)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 | 10.1016/j.bmcl.2003.12.006 | |||
516275 | 61453 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 630 | 11 | 1 | 6 | 7.0 | CCn1nc(Cc2ccc(OC3CCC3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL177033 | 61453 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 630 | 11 | 1 | 6 | 7.0 | CCn1nc(Cc2ccc(OC3CCC3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516220 | 62142 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 666 | 14 | 1 | 6 | 7.6 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OCc5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL177648 | 62142 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 666 | 14 | 1 | 6 | 7.6 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OCc5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516287 | 120056 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 622 | 11 | 1 | 6 | 6.6 | CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1F | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL349974 | 120056 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 622 | 11 | 1 | 6 | 6.6 | CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1F | 10.1016/j.bmcl.2003.12.006 | |||
516276 | 130729 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 618 | 11 | 1 | 6 | 6.8 | CCn1nc(Cc2ccc(OC(C)C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL368204 | 130729 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 618 | 11 | 1 | 6 | 6.8 | CCn1nc(Cc2ccc(OC(C)C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516269 | 168647 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 590 | 10 | 1 | 6 | 6.0 | CCn1nc(Cc2cccc(OC)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL435554 | 168647 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 590 | 10 | 1 | 6 | 6.0 | CCn1nc(Cc2cccc(OC)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
3010267 | 78752 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 512 | 10 | 2 | 4 | 5.1 | O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(c3c[nH]c(Cc4ccccc4)n3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2004.04.078 | |||
CHEMBL2112560 | 78752 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 512 | 10 | 2 | 4 | 5.1 | O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(c3c[nH]c(Cc4ccccc4)n3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2004.04.078 | |||
44461741 | 168156 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 619 | 14 | 1 | 6 | 5.3 | C=CCN(C(=O)NCc1ccc([N+](=O)[O-])cc1)C1CCN(CC[C@@H](CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1 | 10.1016/s0960-894x(01)00492-9 | |||
CHEMBL432360 | 168156 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 619 | 14 | 1 | 6 | 5.3 | C=CCN(C(=O)NCc1ccc([N+](=O)[O-])cc1)C1CCN(CC[C@@H](CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1 | 10.1016/s0960-894x(01)00492-9 | |||
76330829 | 85648 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 605 | 13 | 1 | 6 | 5.6 | C=CCN(C(=O)Nc1ccc([N+](=O)[O-])cc1)C1CCN(CCC(CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1 | 10.1007/s00044-012-0138-3 | |||
CHEMBL2282506 | 85648 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 605 | 13 | 1 | 6 | 5.6 | C=CCN(C(=O)Nc1ccc([N+](=O)[O-])cc1)C1CCN(CCC(CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1 | 10.1007/s00044-012-0138-3 | |||
16073660 | 79809 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 596 | 11 | 0 | 6 | 4.6 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2ccccc2)c2ccc(S(C)(=O)=O)cc2)CC1 | 10.1016/j.bmcl.2006.03.089 | |||
CHEMBL211866 | 79809 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 596 | 11 | 0 | 6 | 4.6 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2ccccc2)c2ccc(S(C)(=O)=O)cc2)CC1 | 10.1016/j.bmcl.2006.03.089 | |||
44565853 | 179139 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 571 | 11 | 1 | 5 | 6.8 | CCc1nc(Cc2ccccc2)sc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL471251 | 179139 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 571 | 11 | 1 | 5 | 6.8 | CCc1nc(Cc2ccccc2)sc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1 | 10.1016/j.ejmech.2008.01.040 | |||
3010278 | 78745 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 589 | 11 | 1 | 5 | 7.0 | CCc1nc(Cc2ccccc2)sc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2004.04.078 | |||
CHEMBL2112553 | 78745 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 589 | 11 | 1 | 5 | 7.0 | CCc1nc(Cc2ccccc2)sc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2004.04.078 | |||
44565853 | 179139 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 571 | 11 | 1 | 5 | 6.8 | CCc1nc(Cc2ccccc2)sc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL471251 | 179139 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 571 | 11 | 1 | 5 | 6.8 | CCc1nc(Cc2ccccc2)sc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1 | 10.1016/j.ejmech.2008.01.040 | |||
76327166 | 85651 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 620 | 14 | 1 | 6 | 5.1 | CCCN(C(=O)OCc1cccc(C(N)=O)c1)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1 | 10.1007/s00044-012-0138-3 | |||
CHEMBL2282509 | 85651 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 620 | 14 | 1 | 6 | 5.1 | CCCN(C(=O)OCc1cccc(C(N)=O)c1)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1 | 10.1007/s00044-012-0138-3 | |||
501051 | 4489 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 512 | 10 | 2 | 4 | 5.4 | O=C(O)[C@@H](c1ccccc1)N1C[C@H](CN2CCC(O)(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL101961 | 4489 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 512 | 10 | 2 | 4 | 5.4 | O=C(O)[C@@H](c1ccccc1)N1C[C@H](CN2CCC(O)(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
516260 | 59861 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 560 | 9 | 1 | 5 | 6.0 | CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL172854 | 59861 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 560 | 9 | 1 | 5 | 6.0 | CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.ejmech.2008.01.040 | |||
44273960 | 99279 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 524 | 11 | 1 | 3 | 6.4 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL281607 | 99279 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 524 | 11 | 1 | 3 | 6.4 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
44565719 | 179224 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 530 | 11 | 1 | 4 | 6.4 | CC(C)C[C@H](C(=O)O)N1C[C@H](CN2CCC(CCSc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL471909 | 179224 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 530 | 11 | 1 | 4 | 6.4 | CC(C)C[C@H](C(=O)O)N1C[C@H](CN2CCC(CCSc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
516342 | 189349 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 541 | 9 | 1 | 5 | 6.2 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)no3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL511634 | 189349 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 541 | 9 | 1 | 5 | 6.2 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)no3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
44274108 | 99208 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 516 | 10 | 1 | 4 | 6.0 | CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCSc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
CHEMBL281176 | 99208 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 516 | 10 | 1 | 4 | 6.0 | CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCSc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
44273960 | 99279 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 524 | 11 | 1 | 3 | 6.4 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
CHEMBL281607 | 99279 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 524 | 11 | 1 | 3 | 6.4 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
490022 | 111657 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 588 | 10 | 0 | 6 | 6.0 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(01)00835-6 | |||
CHEMBL328260 | 111657 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 588 | 10 | 0 | 6 | 6.0 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(01)00835-6 | |||
44357072 | 98545 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 553 | 12 | 1 | 7 | 4.7 | CCCN(c1nccc(OC)n1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL275998 | 98545 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 553 | 12 | 1 | 7 | 4.7 | CCCN(c1nccc(OC)n1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
490020 | 111666 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 616 | 10 | 0 | 6 | 6.4 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)c3ccccc3Cl)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
CHEMBL328297 | 111666 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 616 | 10 | 0 | 6 | 6.4 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)c3ccccc3Cl)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00988-5 | |||
20664149 | 69868 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 580 | 9 | 1 | 5 | 6.7 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccc(-c5ccccc5)cn34)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2005.02.030 | |||
CHEMBL193822 | 69868 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 580 | 9 | 1 | 5 | 6.7 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccc(-c5ccccc5)cn34)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2005.02.030 | |||
516260 | 59861 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 560 | 9 | 1 | 5 | 6.0 | CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.005 | |||
CHEMBL172854 | 59861 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 560 | 9 | 1 | 5 | 6.0 | CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.005 | |||
516236 | 168646 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 560 | 11 | 1 | 5 | 6.0 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.005 | |||
CHEMBL435538 | 168646 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 560 | 11 | 1 | 5 | 6.0 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.005 | |||
490020 | 111666 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 616 | 10 | 0 | 6 | 6.4 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)c3ccccc3Cl)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00605-4 | |||
CHEMBL328297 | 111666 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 616 | 10 | 0 | 6 | 6.4 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)c3ccccc3Cl)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00605-4 | |||
501051 | 4489 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 512 | 10 | 2 | 4 | 5.4 | O=C(O)[C@@H](c1ccccc1)N1C[C@H](CN2CCC(O)(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL101961 | 4489 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 512 | 10 | 2 | 4 | 5.4 | O=C(O)[C@@H](c1ccccc1)N1C[C@H](CN2CCC(O)(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
516260 | 59861 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 560 | 9 | 1 | 5 | 6.0 | CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL172854 | 59861 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 560 | 9 | 1 | 5 | 6.0 | CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.ejmech.2008.01.040 | |||
44273960 | 99279 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 524 | 11 | 1 | 3 | 6.4 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL281607 | 99279 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 524 | 11 | 1 | 3 | 6.4 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
44565719 | 179224 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 530 | 11 | 1 | 4 | 6.4 | CC(C)C[C@H](C(=O)O)N1C[C@H](CN2CCC(CCSc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL471909 | 179224 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 530 | 11 | 1 | 4 | 6.4 | CC(C)C[C@H](C(=O)O)N1C[C@H](CN2CCC(CCSc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
516342 | 189349 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 541 | 9 | 1 | 5 | 6.2 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)no3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL511634 | 189349 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 541 | 9 | 1 | 5 | 6.2 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)no3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
44447734 | 95192 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 523 | 5 | 0 | 5 | 6.1 | CC1(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CCN(C(=O)c2c(Cl)cncc2Cl)CC1 | 10.1016/j.bmcl.2008.01.108 | |||
CHEMBL255644 | 95192 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 523 | 5 | 0 | 5 | 6.1 | CC1(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CCN(C(=O)c2c(Cl)cncc2Cl)CC1 | 10.1016/j.bmcl.2008.01.108 | |||
10413034 | 95233 | None | 0 | Crab-eating macaque | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 483 | 5 | 0 | 5 | 5.4 | Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1 | 10.1016/j.bmcl.2008.01.108 | |||
CHEMBL255856 | 95233 | None | 0 | Crab-eating macaque | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 483 | 5 | 0 | 5 | 5.4 | Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1 | 10.1016/j.bmcl.2008.01.108 | |||
501051 | 4489 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 512 | 10 | 2 | 4 | 5.4 | O=C(O)[C@@H](c1ccccc1)N1C[C@H](CN2CCC(O)(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/s0960-894x(02)00606-6 | |||
CHEMBL101961 | 4489 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 512 | 10 | 2 | 4 | 5.4 | O=C(O)[C@@H](c1ccccc1)N1C[C@H](CN2CCC(O)(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/s0960-894x(02)00606-6 | |||
486605 | 104419 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 654 | 14 | 1 | 6 | 5.7 | CCCN(C(=O)OCc1cccc(C(N)=O)c1)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2cccc(Cl)c2)CC1 | 10.1016/s0960-894x(01)00492-9 | |||
CHEMBL310106 | 104419 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 654 | 14 | 1 | 6 | 5.7 | CCCN(C(=O)OCc1cccc(C(N)=O)c1)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2cccc(Cl)c2)CC1 | 10.1016/s0960-894x(01)00492-9 | |||
486605 | 104419 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 654 | 14 | 1 | 6 | 5.7 | CCCN(C(=O)OCc1cccc(C(N)=O)c1)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2cccc(Cl)c2)CC1 | 10.1021/acs.jmedchem.6b01309 | |||
CHEMBL310106 | 104419 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 654 | 14 | 1 | 6 | 5.7 | CCCN(C(=O)OCc1cccc(C(N)=O)c1)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2cccc(Cl)c2)CC1 | 10.1021/acs.jmedchem.6b01309 | |||
44384927 | 168665 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 541 | 9 | 1 | 5 | 6.2 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3oncc3Cc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2003.12.004 | |||
CHEMBL435709 | 168665 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 541 | 9 | 1 | 5 | 6.2 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3oncc3Cc3ccccc3)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2003.12.004 | |||
516197 | 59642 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 630 | 11 | 1 | 6 | 6.5 | CCn1nc(Cc2ccc(OC(F)(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL172013 | 59642 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 630 | 11 | 1 | 6 | 6.5 | CCn1nc(Cc2ccc(OC(F)(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516309 | 59726 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 658 | 14 | 1 | 6 | 7.7 | CCCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C5CCCCC5)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL172327 | 59726 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 658 | 14 | 1 | 6 | 7.7 | CCCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C5CCCCC5)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 | 10.1016/j.bmcl.2003.12.006 | |||
516260 | 59861 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 560 | 9 | 1 | 5 | 6.0 | CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL172854 | 59861 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 560 | 9 | 1 | 5 | 6.0 | CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516273 | 60492 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 632 | 13 | 1 | 6 | 7.2 | CCCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL175424 | 60492 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 632 | 13 | 1 | 6 | 7.2 | CCCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 | 10.1016/j.bmcl.2003.12.006 | |||
516218 | 61285 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 618 | 13 | 1 | 6 | 6.8 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC(C)C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL176624 | 61285 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 618 | 13 | 1 | 6 | 6.8 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC(C)C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516244 | 61748 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 632 | 15 | 1 | 6 | 7.2 | CCCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL177168 | 61748 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 632 | 15 | 1 | 6 | 7.2 | CCCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 | 10.1016/j.bmcl.2003.12.006 | |||
516195 | 61787 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 618 | 11 | 1 | 6 | 6.8 | CCn1nc(Cc2ccc(OC(C)(C)C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL177204 | 61787 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 618 | 11 | 1 | 6 | 6.8 | CCn1nc(Cc2ccc(OC(C)(C)C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516242 | 96713 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 604 | 13 | 1 | 6 | 6.4 | CCOc1cccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)c1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL263787 | 96713 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 604 | 13 | 1 | 6 | 6.4 | CCOc1cccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)c1 | 10.1016/j.bmcl.2003.12.006 | |||
516304 | 120560 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 726 | 12 | 1 | 7 | 7.4 | CCn1nc(Cc2ccc(S(=O)(=O)c3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL354413 | 120560 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 726 | 12 | 1 | 7 | 7.4 | CCn1nc(Cc2ccc(S(=O)(=O)c3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516272 | 120892 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 618 | 12 | 1 | 6 | 6.8 | CCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL355809 | 120892 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 618 | 12 | 1 | 6 | 6.8 | CCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 | 10.1016/j.bmcl.2003.12.006 | |||
516200 | 128122 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 601 | 11 | 1 | 7 | 5.5 | CCn1nc(Cc2ccc(OC)c(C#N)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL366492 | 128122 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 601 | 11 | 1 | 7 | 5.5 | CCn1nc(Cc2ccc(OC)c(C#N)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516258 | 128589 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 616 | 11 | 1 | 5 | 7.3 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C(C)(C)C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL366742 | 128589 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 616 | 11 | 1 | 5 | 7.3 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C(C)(C)C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516191 | 131684 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 604 | 13 | 1 | 6 | 6.4 | CCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL369278 | 131684 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 604 | 13 | 1 | 6 | 6.4 | CCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 | 10.1016/j.bmcl.2003.12.006 | |||
44325665 | 111465 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 632 | 10 | 0 | 6 | 6.9 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)c3cccc4ccccc34)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(01)00545-5 | |||
CHEMBL327241 | 111465 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 632 | 10 | 0 | 6 | 6.9 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)c3cccc4ccccc34)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(01)00545-5 | |||
490022 | 111657 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 588 | 10 | 0 | 6 | 6.0 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(01)00545-5 | |||
CHEMBL328260 | 111657 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 588 | 10 | 0 | 6 | 6.0 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(01)00545-5 | |||
490020 | 111666 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 616 | 10 | 0 | 6 | 6.4 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)c3ccccc3Cl)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(01)00545-5 | |||
CHEMBL328297 | 111666 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 616 | 10 | 0 | 6 | 6.4 | C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)c3ccccc3Cl)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(01)00545-5 | |||
44401760 | 168689 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 572 | 8 | 1 | 5 | 6.0 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccc(C(F)(F)F)cn34)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2005.02.030 | |||
CHEMBL435886 | 168689 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 572 | 8 | 1 | 5 | 6.0 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccc(C(F)(F)F)cn34)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2005.02.030 | |||
44565037 | 193093 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 501 | 8 | 1 | 5 | 5.8 | Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CCC(F)(F)CC2)c2ccccc2)CC1 | 10.1016/j.bmcl.2009.01.008 | |||
CHEMBL489324 | 193093 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 501 | 8 | 1 | 5 | 5.8 | Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CCC(F)(F)CC2)c2ccccc2)CC1 | 10.1016/j.bmcl.2009.01.008 | |||
CHEMBL522259 | 193093 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 501 | 8 | 1 | 5 | 5.8 | Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CCC(F)(F)CC2)c2ccccc2)CC1 | 10.1016/j.bmcl.2009.01.008 | |||
20672384 | 69606 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 542 | 10 | 1 | 5 | 6.3 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(CCCn3cnc4ccccc43)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2005.02.030 | |||
CHEMBL193440 | 69606 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 542 | 10 | 1 | 5 | 6.3 | O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(CCCn3cnc4ccccc43)CC2)[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2005.02.030 | |||
44565852 | 172764 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 555 | 11 | 1 | 5 | 6.4 | CCc1nc(Cc2ccccc2)oc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL449758 | 172764 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 555 | 11 | 1 | 5 | 6.4 | CCc1nc(Cc2ccccc2)oc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1 | 10.1016/j.ejmech.2008.01.040 | |||
44401751 | 70101 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 538 | 8 | 1 | 5 | 5.7 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccc(Cl)cn34)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2005.02.030 | |||
CHEMBL193988 | 70101 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 538 | 8 | 1 | 5 | 5.7 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccc(Cl)cn34)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2005.02.030 | |||
44565852 | 172764 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 555 | 11 | 1 | 5 | 6.4 | CCc1nc(Cc2ccccc2)oc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL449758 | 172764 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 555 | 11 | 1 | 5 | 6.4 | CCc1nc(Cc2ccccc2)oc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1 | 10.1016/j.ejmech.2008.01.040 | |||
3010277 | 78748 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 573 | 11 | 1 | 5 | 6.5 | CCc1nc(Cc2ccccc2)oc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2004.04.078 | |||
CHEMBL2112556 | 78748 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 573 | 11 | 1 | 5 | 6.5 | CCc1nc(Cc2ccccc2)oc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2004.04.078 | |||
516366 | 168668 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 574 | 12 | 1 | 5 | 6.4 | CCC(CC)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL435727 | 168668 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 574 | 12 | 1 | 5 | 6.4 | CCC(CC)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
44565718 | 179065 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 562 | 11 | 1 | 5 | 5.1 | CC(C)C[C@H](C(=O)O)N1C[C@H](CN2CCC(CCS(=O)(=O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL470510 | 179065 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 562 | 11 | 1 | 5 | 5.1 | CC(C)C[C@H](C(=O)O)N1C[C@H](CN2CCC(CCS(=O)(=O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
44274106 | 76550 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 548 | 10 | 1 | 5 | 4.7 | CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCS(=O)(=O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
CHEMBL20602 | 76550 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 548 | 10 | 1 | 5 | 4.7 | CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCS(=O)(=O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/s0960-894x(02)00829-6 | |||
516203 | 60357 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 560 | 11 | 1 | 5 | 6.0 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.005 | |||
CHEMBL174457 | 60357 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 560 | 11 | 1 | 5 | 6.0 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.005 | |||
516366 | 168668 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 574 | 12 | 1 | 5 | 6.4 | CCC(CC)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.005 | |||
CHEMBL435727 | 168668 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 574 | 12 | 1 | 5 | 6.4 | CCC(CC)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.005 | |||
44205000 | 170298 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 594 | 8 | 0 | 6 | 7.0 | COC(=O)C(c1ccc(F)cc1)N1CCC(CCN2[C@H]3CC[C@@H]2C[C@H](n2c(C)nc4ccccc42)C3)(c2ccccc2)CC1 | 10.1016/j.bmcl.2009.02.014 | |||
CHEMBL444497 | 170298 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 594 | 8 | 0 | 6 | 7.0 | COC(=O)C(c1ccc(F)cc1)N1CCC(CCN2[C@H]3CC[C@@H]2C[C@H](n2c(C)nc4ccccc42)C3)(c2ccccc2)CC1 | 10.1016/j.bmcl.2009.02.014 | |||
516366 | 168668 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 574 | 12 | 1 | 5 | 6.4 | CCC(CC)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL435727 | 168668 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 574 | 12 | 1 | 5 | 6.4 | CCC(CC)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
44565718 | 179065 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 562 | 11 | 1 | 5 | 5.1 | CC(C)C[C@H](C(=O)O)N1C[C@H](CN2CCC(CCS(=O)(=O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL470510 | 179065 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 562 | 11 | 1 | 5 | 5.1 | CC(C)C[C@H](C(=O)O)N1C[C@H](CN2CCC(CCS(=O)(=O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.ejmech.2008.01.040 | |||
10413034 | 95233 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 483 | 5 | 0 | 5 | 5.4 | Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1 | 10.1016/j.bmcl.2008.01.108 | |||
CHEMBL255856 | 95233 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 483 | 5 | 0 | 5 | 5.4 | Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1 | 10.1016/j.bmcl.2008.01.108 | |||
16041411 | 92628 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 572 | 8 | 1 | 6 | 5.6 | O=C(O)c1ccc(Sc2ccc(CN3CCC(N4C(=O)N(C5CCOCC5)C[C@H]4c4ccccc4)CC3)cn2)cc1 | 10.1021/jm401101p | |||
CHEMBL2434978 | 92628 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 572 | 8 | 1 | 6 | 5.6 | O=C(O)c1ccc(Sc2ccc(CN3CCC(N4C(=O)N(C5CCOCC5)C[C@H]4c4ccccc4)CC3)cn2)cc1 | 10.1021/jm401101p | |||
58835113 | 92688 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 607 | 8 | 1 | 7 | 5.6 | O=C(O)c1ccc(Sc2ncc(CN3CCC(N4C(=O)N(C5CCOCC5)C[C@H]4c4cccc(Cl)c4)CC3)cn2)cc1 | 10.1021/jm401101p | |||
CHEMBL2435844 | 92688 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 607 | 8 | 1 | 7 | 5.6 | O=C(O)c1ccc(Sc2ncc(CN3CCC(N4C(=O)N(C5CCOCC5)C[C@H]4c4cccc(Cl)c4)CC3)cn2)cc1 | 10.1021/jm401101p | |||
58834946 | 92689 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 604 | 8 | 2 | 7 | 5.5 | Cc1nc(Nc2ccc(C(=O)O)cc2)ncc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2cccc(Cl)c2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435845 | 92689 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 604 | 8 | 2 | 7 | 5.5 | Cc1nc(Nc2ccc(C(=O)O)cc2)ncc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2cccc(Cl)c2)CC1 | 10.1021/jm401101p | |||
72711741 | 92703 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 579 | 9 | 1 | 4 | 6.4 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(CC3CCCCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435859 | 92703 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 579 | 9 | 1 | 4 | 6.4 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(CC3CCCCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
72711739 | 92751 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 551 | 8 | 1 | 4 | 5.7 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435907 | 92751 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 551 | 8 | 1 | 4 | 5.7 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCC3)C[C@H]2c2ccccc2)CC1 | 10.1021/jm401101p | |||
59458247 | 92756 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 571 | 8 | 1 | 5 | 6.2 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccsc2)CC1 | 10.1021/jm401101p | |||
CHEMBL2435912 | 92756 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 571 | 8 | 1 | 5 | 6.2 | Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccsc2)CC1 | 10.1021/jm401101p | |||
516208 | 59518 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 585 | 11 | 1 | 6 | 5.9 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4cccc(C#N)c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL171468 | 59518 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 585 | 11 | 1 | 6 | 5.9 | CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4cccc(C#N)c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
516286 | 60415 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 615 | 10 | 1 | 7 | 5.9 | CCn1nc(Cc2ccc(OC)c(C#N)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL174904 | 60415 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 615 | 10 | 1 | 7 | 5.9 | CCn1nc(Cc2ccc(OC)c(C#N)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516270 | 61245 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 604 | 11 | 1 | 6 | 6.4 | CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL176604 | 61245 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 604 | 11 | 1 | 6 | 6.4 | CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 | 10.1016/j.bmcl.2003.12.006 | |||
516300 | 128531 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 620 | 10 | 1 | 5 | 7.2 | CCn1nc(Cc2ccc(Cl)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL366600 | 128531 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 620 | 10 | 1 | 5 | 7.2 | CCn1nc(Cc2ccc(Cl)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516213 | 129393 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 604 | 13 | 1 | 6 | 6.4 | CCOc1cccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)c1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL367102 | 129393 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 604 | 13 | 1 | 6 | 6.4 | CCOc1cccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)c1 | 10.1016/j.bmcl.2003.12.006 | |||
516298 | 130752 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 622 | 10 | 1 | 5 | 6.8 | CCn1nc(Cc2cc(F)cc(F)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL368332 | 130752 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 622 | 10 | 1 | 5 | 6.8 | CCn1nc(Cc2cc(F)cc(F)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 | 10.1016/j.bmcl.2003.12.006 | |||
516236 | 168646 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 560 | 11 | 1 | 5 | 6.0 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
CHEMBL435538 | 168646 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 560 | 11 | 1 | 5 | 6.0 | CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2003.12.006 | |||
3009355 | 3989 | None | 18 | Mouse | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 533 | 6 | 0 | 6 | 4.5 | COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F | 10.1016/j.ejmech.2018.01.085 | |||
807 | 3989 | None | 18 | Mouse | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 533 | 6 | 0 | 6 | 4.5 | COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F | 10.1016/j.ejmech.2018.01.085 | |||
CHEMBL82301 | 3989 | None | 18 | Mouse | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 533 | 6 | 0 | 6 | 4.5 | COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F | 10.1016/j.ejmech.2018.01.085 | |||
DB06652 | 3989 | None | 18 | Mouse | Binding | pIC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 533 | 6 | 0 | 6 | 4.5 | COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F | 10.1016/j.ejmech.2018.01.085 | |||
44590635 | 177004 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 493 | 10 | 1 | 3 | 5.1 | CCN(C(=O)Cc1ccc(F)cc1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 | 10.1016/j.bmcl.2009.01.009 | |||
CHEMBL461690 | 177004 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 493 | 10 | 1 | 3 | 5.1 | CCN(C(=O)Cc1ccc(F)cc1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 | 10.1016/j.bmcl.2009.01.009 | |||
76335673 | 104844 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 652 | 18 | 1 | 6 | 8.8 | Cc1nnc(CCCCCCCCCCN=[N+]=[N-])n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1 | 10.1021/ml400370w | |||
CHEMBL3109175 | 104844 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 652 | 18 | 1 | 6 | 8.8 | Cc1nnc(CCCCCCCCCCN=[N+]=[N-])n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1 | 10.1021/ml400370w | |||
489315 | 107416 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 474 | 9 | 1 | 3 | 6.1 | OC1(CCCc2ccccc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(01)00652-7 | |||
CHEMBL317710 | 107416 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 474 | 9 | 1 | 3 | 6.1 | OC1(CCCc2ccccc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(01)00652-7 | |||
23650547 | 179185 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 459 | 6 | 0 | 3 | 4.4 | Cc1cccc(C)c1C(=O)N1CCC(N2CC[C@@H](N(Cc3ccccc3)C(=O)C3CC3)C2)CC1 | 10.1016/j.bmcl.2009.01.012 | |||
CHEMBL471623 | 179185 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 459 | 6 | 0 | 3 | 4.4 | Cc1cccc(C)c1C(=O)N1CCC(N2CC[C@@H](N(Cc3ccccc3)C(=O)C3CC3)C2)CC1 | 10.1016/j.bmcl.2009.01.012 | |||
44590394 | 183988 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 485 | 6 | 0 | 3 | 5.0 | Cc1cccc(C)c1C(=O)N1[C@H]2CC[C@@H]1C[C@@H](N1CC[C@@H](N(Cc3ccccc3)C(=O)C3CC3)C1)C2 | 10.1016/j.bmcl.2009.01.012 | |||
CHEMBL481068 | 183988 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 485 | 6 | 0 | 3 | 5.0 | Cc1cccc(C)c1C(=O)N1[C@H]2CC[C@@H]1C[C@@H](N1CC[C@@H](N(Cc3ccccc3)C(=O)C3CC3)C1)C2 | 10.1016/j.bmcl.2009.01.012 | |||
59959034 | 79041 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 505 | 8 | 1 | 6 | 4.4 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4cnccn34)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2005.02.030 | |||
CHEMBL2113088 | 79041 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 505 | 8 | 1 | 6 | 4.4 | O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4cnccn34)CC2)[C@@H](c2cccc(F)c2)C1 | 10.1016/j.bmcl.2005.02.030 | |||
44332814 | 163766 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 556 | 11 | 2 | 6 | 5.2 | OC1(CCCc2ccc(Cc3nnn[nH]3)cc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00605-4 | |||
CHEMBL420465 | 163766 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 556 | 11 | 2 | 6 | 5.2 | OC1(CCCc2ccc(Cc3nnn[nH]3)cc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1 | 10.1016/s0960-894x(02)00605-4 | |||
16073662 | 139363 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 630 | 11 | 0 | 6 | 5.2 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cccc(Cl)c2)CC1 | 10.1016/j.bmcl.2006.03.089 | |||
CHEMBL379082 | 139363 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 630 | 11 | 0 | 6 | 5.2 | CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cccc(Cl)c2)CC1 | 10.1016/j.bmcl.2006.03.089 | |||
25132603 | 103346 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 546 | 5 | 0 | 4 | 7.2 | Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CCC1(c2cccc(Cl)c2)CCN(C(=O)C(C)(C)C)CC1 | 10.1021/jm800598a | |||
CHEMBL3084499 | 103346 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 546 | 5 | 0 | 4 | 7.2 | Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CCC1(c2cccc(Cl)c2)CCN(C(=O)C(C)(C)C)CC1 | 10.1021/jm800598a | |||
44565854 | 183969 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 559 | 11 | 1 | 5 | 6.7 | CCc1nc(Cc2ccccc2)sc1C1CCN(C[C@H]2CN([C@H](CC(C)C)C(=O)O)C[C@@H]2c2ccccc2)CC1 | 10.1016/j.ejmech.2008.01.040 | |||
CHEMBL480890 | 183969< |