Ligand source activities (1 row/activity)





Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
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74265 210806 None 69 Human Functional pEC50 = 6 6.0 -2 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 0 0 2 4.0 Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C 10.1021/jm301121j
CHEMBL99384 210806 None 69 Human Functional pEC50 = 6 6.0 -2 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 0 0 2 4.0 Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C 10.1021/jm301121j
14434082 83816 None 16 Human Functional pEC50 = 5 5.0 -1 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccnc2c1ccc1c(C=O)ccnc12 10.1021/jm301121j
CHEMBL2205801 83816 None 16 Human Functional pEC50 = 5 5.0 -1 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccnc2c1ccc1c(C=O)ccnc12 10.1021/jm301121j
16726107 83522 None 2 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayAgonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assay
ChEMBL 475 7 1 6 4.4 Cc1ccc(CN2CCC(CNC(=O)C3CCN(c4ccc(-c5cccs5)nn4)CC3)C2)cc1 10.1021/jm061389p
CHEMBL220199 83522 None 2 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayAgonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assay
ChEMBL 475 7 1 6 4.4 Cc1ccc(CN2CCC(CNC(=O)C3CCN(c4ccc(-c5cccs5)nn4)CC3)C2)cc1 10.1021/jm061389p
14338 4369 None 74 Human Functional pEC50 = 5.0 5.0 -3 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1 10.1021/jm301121j
CHEMBL101165 4369 None 74 Human Functional pEC50 = 5.0 5.0 -3 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1 10.1021/jm301121j
14338 4369 None 74 Human Functional pEC50 = 4.9 4.9 -3 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1 10.1021/jm301121j
CHEMBL101165 4369 None 74 Human Functional pEC50 = 4.9 4.9 -3 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1 10.1021/jm301121j
16301115 83467 None 2 Human Functional pEC50 = 4.9 4.9 - 1
Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayAgonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assay
ChEMBL 435 7 1 6 3.8 Cc1ccc(-n2c(C)nnc2SCC(=O)NC2CCN(Cc3ccccc3)CC2)cc1 10.1021/jm061389p
CHEMBL219769 83467 None 2 Human Functional pEC50 = 4.9 4.9 - 1
Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayAgonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assay
ChEMBL 435 7 1 6 3.8 Cc1ccc(-n2c(C)nnc2SCC(=O)NC2CCN(Cc3ccccc3)CC2)cc1 10.1021/jm061389p
93149 107257 None 55 Human Functional pEC50 = 5.8 5.8 -16 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1ccnc2c1ccc1cccnc12 10.1021/jm301121j
CHEMBL316589 107257 None 55 Human Functional pEC50 = 5.8 5.8 -16 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1ccnc2c1ccc1cccnc12 10.1021/jm301121j
3258407 84938 None 14 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayAgonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assay
ChEMBL 389 9 1 5 4.9 C=C(C)Cc1c(C)c(C#N)c2nc3ccccc3n2c1NCCCN(CC)CC 10.1021/jm061389p
CHEMBL223686 84938 None 14 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayAgonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assay
ChEMBL 389 9 1 5 4.9 C=C(C)Cc1c(C)c(C#N)c2nc3ccccc3n2c1NCCCN(CC)CC 10.1021/jm061389p
12987698 83823 None 3 Human Functional pEC50 = 5.7 5.7 2 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1cnc2c(ccc3cc(C)cnc32)c1 10.1021/jm301121j
CHEMBL2205809 83823 None 3 Human Functional pEC50 = 5.7 5.7 2 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1cnc2c(ccc3cc(C)cnc32)c1 10.1021/jm301121j
1474 154488 None 79 Human Functional pEC50 = 4.7 4.7 -1 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 156 1 0 2 2.1 c1ccc(-c2ccccn2)nc1 10.1021/jm301121j
CHEMBL39879 154488 None 79 Human Functional pEC50 = 4.7 4.7 -1 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 156 1 0 2 2.1 c1ccc(-c2ccccn2)nc1 10.1021/jm301121j
12987698 83823 None 3 Human Functional pEC50 = 5.7 5.7 2 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1cnc2c(ccc3cc(C)cnc32)c1 10.1021/jm301121j
CHEMBL2205809 83823 None 3 Human Functional pEC50 = 5.7 5.7 2 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1cnc2c(ccc3cc(C)cnc32)c1 10.1021/jm301121j
15783796 83825 None 0 Human Functional pEC50 = 5.7 5.7 -3 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cnc2c(ccc3cccnc32)c1 10.1021/jm301121j
CHEMBL2205810 83825 None 0 Human Functional pEC50 = 5.7 5.7 -3 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cnc2c(ccc3cccnc32)c1 10.1021/jm301121j
93149 107257 None 55 Human Functional pEC50 = 5.7 5.7 -16 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1ccnc2c1ccc1cccnc12 10.1021/jm301121j
CHEMBL316589 107257 None 55 Human Functional pEC50 = 5.7 5.7 -16 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1ccnc2c1ccc1cccnc12 10.1021/jm301121j
2733927 83822 None 59 Human Functional pEC50 = 4.7 4.7 -4 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 216 3 0 4 2.2 COc1ccnc(-c2cc(OC)ccn2)c1 10.1021/jm301121j
CHEMBL2205808 83822 None 59 Human Functional pEC50 = 4.7 4.7 -4 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 216 3 0 4 2.2 COc1ccnc(-c2cc(OC)ccn2)c1 10.1021/jm301121j
1474 154488 None 79 Human Functional pEC50 = 4.7 4.7 -1 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 156 1 0 2 2.1 c1ccc(-c2ccccn2)nc1 10.1021/jm301121j
CHEMBL39879 154488 None 79 Human Functional pEC50 = 4.7 4.7 -1 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 156 1 0 2 2.1 c1ccc(-c2ccccn2)nc1 10.1021/jm301121j
16728788 83468 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayAgonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assay
ChEMBL 450 7 1 7 3.4 Cc1cc(CN2CCN(C)CC2)ccc1NC(=O)CSc1nnc(C)n1-c1ccccc1 10.1021/jm061389p
CHEMBL219770 83468 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayAgonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assay
ChEMBL 450 7 1 7 3.4 Cc1cc(CN2CCN(C)CC2)ccc1NC(=O)CSc1nnc(C)n1-c1ccccc1 10.1021/jm061389p
15783796 83825 None 0 Human Functional pEC50 = 5.7 5.7 -3 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cnc2c(ccc3cccnc32)c1 10.1021/jm301121j
CHEMBL2205810 83825 None 0 Human Functional pEC50 = 5.7 5.7 -3 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cnc2c(ccc3cccnc32)c1 10.1021/jm301121j
2733927 83822 None 59 Human Functional pEC50 = 4.7 4.7 -4 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 216 3 0 4 2.2 COc1ccnc(-c2cc(OC)ccn2)c1 10.1021/jm301121j
CHEMBL2205808 83822 None 59 Human Functional pEC50 = 4.7 4.7 -4 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 216 3 0 4 2.2 COc1ccnc(-c2cc(OC)ccn2)c1 10.1021/jm301121j
15664 83821 None 63 Human Functional pEC50 = 5.6 5.6 2 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1 10.1021/jm301121j
CHEMBL2205807 83821 None 63 Human Functional pEC50 = 5.6 5.6 2 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1 10.1021/jm301121j
137660245 159379 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Positive allosteric modulation of human CCR5 expressed in HEK293T cells co-expressing CAMYEL assessed as increase in CCL4-induced inhibition of forskolin-stimulated cAMP accumulation after 10 mins by BRET assayPositive allosteric modulation of human CCR5 expressed in HEK293T cells co-expressing CAMYEL assessed as increase in CCL4-induced inhibition of forskolin-stimulated cAMP accumulation after 10 mins by BRET assay
ChEMBL 461 7 1 4 4.4 CC(C)CN1CC(C(=O)Nc2ccc(CN(C)C3CCOCC3)cc2)=Cc2ccccc2C1=O 10.1016/j.ejmech.2017.04.046
CHEMBL4099473 159379 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Positive allosteric modulation of human CCR5 expressed in HEK293T cells co-expressing CAMYEL assessed as increase in CCL4-induced inhibition of forskolin-stimulated cAMP accumulation after 10 mins by BRET assayPositive allosteric modulation of human CCR5 expressed in HEK293T cells co-expressing CAMYEL assessed as increase in CCL4-induced inhibition of forskolin-stimulated cAMP accumulation after 10 mins by BRET assay
ChEMBL 461 7 1 4 4.4 CC(C)CN1CC(C(=O)Nc2ccc(CN(C)C3CCOCC3)cc2)=Cc2ccccc2C1=O 10.1016/j.ejmech.2017.04.046
15664 83821 None 63 Human Functional pEC50 = 5.6 5.6 2 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1 10.1021/jm301121j
CHEMBL2205807 83821 None 63 Human Functional pEC50 = 5.6 5.6 2 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1 10.1021/jm301121j
72792 202179 None 52 Human Functional pEC50 = 5.6 5.6 -5 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12 10.1021/jm301121j
CHEMBL593442 202179 None 52 Human Functional pEC50 = 5.6 5.6 -5 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12 10.1021/jm301121j
72792 202179 None 52 Human Functional pEC50 = 5.6 5.6 -5 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12 10.1021/jm301121j
CHEMBL593442 202179 None 52 Human Functional pEC50 = 5.6 5.6 -5 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12 10.1021/jm301121j
70848 209130 None 67 Human Functional pEC50 = 4.5 4.5 -5 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 233 2 0 3 3.2 c1ccc(-c2cccc(-c3ccccn3)n2)nc1 10.1021/jm301121j
CHEMBL89445 209130 None 67 Human Functional pEC50 = 4.5 4.5 -5 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 233 2 0 3 3.2 c1ccc(-c2cccc(-c3ccccn3)n2)nc1 10.1021/jm301121j
1167892 83470 None 0 Human Functional pEC50 = 5.5 5.5 - 1
Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayAgonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assay
ChEMBL 463 9 1 6 4.7 Cc1ccc(NC(=O)CSc2nnc(CCN3CCCCC3)n2Cc2ccccc2)c(C)c1 10.1021/jm061389p
CHEMBL219781 83470 None 0 Human Functional pEC50 = 5.5 5.5 - 1
Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayAgonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assay
ChEMBL 463 9 1 6 4.7 Cc1ccc(NC(=O)CSc2nnc(CCN3CCCCC3)n2Cc2ccccc2)c(C)c1 10.1021/jm061389p
70848 209130 None 67 Human Functional pEC50 = 4.5 4.5 -5 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 233 2 0 3 3.2 c1ccc(-c2cccc(-c3ccccn3)n2)nc1 10.1021/jm301121j
CHEMBL89445 209130 None 67 Human Functional pEC50 = 4.5 4.5 -5 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 233 2 0 3 3.2 c1ccc(-c2cccc(-c3ccccn3)n2)nc1 10.1021/jm301121j
10585 1079 None 1 Human Functional pEC50 = 8.4 8.4 -1 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)
ChEMBL 351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C 10.1021/acs.jmedchem.9b00742
145996522 1079 None 1 Human Functional pEC50 = 8.4 8.4 -1 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)
ChEMBL 351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C 10.1021/acs.jmedchem.9b00742
CHEMBL4531005 1079 None 1 Human Functional pEC50 = 8.4 8.4 -1 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)
ChEMBL 351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C 10.1021/acs.jmedchem.9b00742
12425 6 None 76 Human Functional pEC50 = 5.3 5.3 -4 4
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
1318 6 None 76 Human Functional pEC50 = 5.3 5.3 -4 4
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
CHEMBL415879 6 None 76 Human Functional pEC50 = 5.3 5.3 -4 4
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
DB02365 6 None 76 Human Functional pEC50 = 5.3 5.3 -4 4
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
10585 1079 None 1 Human Functional pEC50 = 8.3 8.3 -1 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)
ChEMBL 351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C 10.1021/acs.jmedchem.9b00742
145996522 1079 None 1 Human Functional pEC50 = 8.3 8.3 -1 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)
ChEMBL 351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C 10.1021/acs.jmedchem.9b00742
CHEMBL4531005 1079 None 1 Human Functional pEC50 = 8.3 8.3 -1 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)
ChEMBL 351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C 10.1021/acs.jmedchem.9b00742
155491018 174187 None 1 Human Functional pEC50 = 8.3 8.3 2 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 30 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 30 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)
ChEMBL 395 3 2 5 3.1 CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 10.1021/acs.jmedchem.9b00742
CHEMBL4544504 174187 None 1 Human Functional pEC50 = 8.3 8.3 2 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 30 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 30 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)
ChEMBL 395 3 2 5 3.1 CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 10.1021/acs.jmedchem.9b00742
155491018 174187 None 1 Human Functional pEC50 = 8.3 8.3 2 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 30 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 30 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)
ChEMBL 395 3 2 5 3.1 CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 10.1021/acs.jmedchem.9b00742
CHEMBL4544504 174187 None 1 Human Functional pEC50 = 8.3 8.3 2 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 30 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 30 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)
ChEMBL 395 3 2 5 3.1 CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 10.1021/acs.jmedchem.9b00742
12425 6 None 76 Human Functional pEC50 = 5.3 5.3 -4 4
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
1318 6 None 76 Human Functional pEC50 = 5.3 5.3 -4 4
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
CHEMBL415879 6 None 76 Human Functional pEC50 = 5.3 5.3 -4 4
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
DB02365 6 None 76 Human Functional pEC50 = 5.3 5.3 -4 4
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
155491018 174187 None 1 Human Functional pEC50 = 8.2 8.2 2 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)
ChEMBL 395 3 2 5 3.1 CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 10.1021/acs.jmedchem.9b00742
CHEMBL4544504 174187 None 1 Human Functional pEC50 = 8.2 8.2 2 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)
ChEMBL 395 3 2 5 3.1 CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 10.1021/acs.jmedchem.9b00742
155491018 174187 None 1 Human Functional pEC50 = 8.2 8.2 2 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)
ChEMBL 395 3 2 5 3.1 CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 10.1021/acs.jmedchem.9b00742
CHEMBL4544504 174187 None 1 Human Functional pEC50 = 8.2 8.2 2 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 100 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)
ChEMBL 395 3 2 5 3.1 CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 10.1021/acs.jmedchem.9b00742
65237 137711 None 68 Human Functional pEC50 = 4.2 4.2 -28 2
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccc2ccc3ccc(C)nc3c2n1 10.1021/jm301121j
CHEMBL375781 137711 None 68 Human Functional pEC50 = 4.2 4.2 -28 2
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccc2ccc3ccc(C)nc3c2n1 10.1021/jm301121j
65237 137711 None 68 Human Functional pEC50 = 4.2 4.2 -28 2
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccc2ccc3ccc(C)nc3c2n1 10.1021/jm301121j
CHEMBL375781 137711 None 68 Human Functional pEC50 = 4.2 4.2 -28 2
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccc2ccc3ccc(C)nc3c2n1 10.1021/jm301121j
183790 3742 None 8 Human Functional pEC50 = 8.2 8.2 -2 5
Positive allosteric modulation of human CCR5 expressed in HEK293T cells co-expressing CAMYEL assessed as increase in CCL4-induced inhibition of forskolin-stimulated cAMP accumulation after 10 mins by BRET assayPositive allosteric modulation of human CCR5 expressed in HEK293T cells co-expressing CAMYEL assessed as increase in CCL4-induced inhibition of forskolin-stimulated cAMP accumulation after 10 mins by BRET assay
ChEMBL 495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C 10.1016/j.ejmech.2017.04.046
783 3742 None 8 Human Functional pEC50 = 8.2 8.2 -2 5
Positive allosteric modulation of human CCR5 expressed in HEK293T cells co-expressing CAMYEL assessed as increase in CCL4-induced inhibition of forskolin-stimulated cAMP accumulation after 10 mins by BRET assayPositive allosteric modulation of human CCR5 expressed in HEK293T cells co-expressing CAMYEL assessed as increase in CCL4-induced inhibition of forskolin-stimulated cAMP accumulation after 10 mins by BRET assay
ChEMBL 495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C 10.1016/j.ejmech.2017.04.046
CHEMBL1178786 3742 None 8 Human Functional pEC50 = 8.2 8.2 -2 5
Positive allosteric modulation of human CCR5 expressed in HEK293T cells co-expressing CAMYEL assessed as increase in CCL4-induced inhibition of forskolin-stimulated cAMP accumulation after 10 mins by BRET assayPositive allosteric modulation of human CCR5 expressed in HEK293T cells co-expressing CAMYEL assessed as increase in CCL4-induced inhibition of forskolin-stimulated cAMP accumulation after 10 mins by BRET assay
ChEMBL 495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C 10.1016/j.ejmech.2017.04.046
10585 1079 None 1 Human Functional pEC50 = 8.1 8.1 -1 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 1000 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 1000 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)
ChEMBL 351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C 10.1021/acs.jmedchem.9b00742
145996522 1079 None 1 Human Functional pEC50 = 8.1 8.1 -1 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 1000 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 1000 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)
ChEMBL 351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C 10.1021/acs.jmedchem.9b00742
CHEMBL4531005 1079 None 1 Human Functional pEC50 = 8.1 8.1 -1 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 1000 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 1000 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)
ChEMBL 351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C 10.1021/acs.jmedchem.9b00742
10585 1079 None 1 Human Functional pEC50 = 8.1 8.1 -1 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)
ChEMBL 351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C 10.1021/acs.jmedchem.9b00742
145996522 1079 None 1 Human Functional pEC50 = 8.1 8.1 -1 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)
ChEMBL 351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C 10.1021/acs.jmedchem.9b00742
CHEMBL4531005 1079 None 1 Human Functional pEC50 = 8.1 8.1 -1 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)
ChEMBL 351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C 10.1021/acs.jmedchem.9b00742
10585 1079 None 1 Human Functional pEC50 = 8.1 8.1 -1 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)
ChEMBL 351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C 10.1021/acs.jmedchem.9b00742
145996522 1079 None 1 Human Functional pEC50 = 8.1 8.1 -1 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)
ChEMBL 351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C 10.1021/acs.jmedchem.9b00742
CHEMBL4531005 1079 None 1 Human Functional pEC50 = 8.1 8.1 -1 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)
ChEMBL 351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C 10.1021/acs.jmedchem.9b00742
155491018 174187 None 1 Human Functional pEC50 = 8.1 8.1 2 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)
ChEMBL 395 3 2 5 3.1 CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 10.1021/acs.jmedchem.9b00742
CHEMBL4544504 174187 None 1 Human Functional pEC50 = 8.1 8.1 2 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 8.42 +/- 0.06 No_unit)
ChEMBL 395 3 2 5 3.1 CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 10.1021/acs.jmedchem.9b00742
10585 1079 None 1 Human Functional pEC50 = 8.1 8.1 -1 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 1000 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 1000 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)
ChEMBL 351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C 10.1021/acs.jmedchem.9b00742
145996522 1079 None 1 Human Functional pEC50 = 8.1 8.1 -1 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 1000 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 1000 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)
ChEMBL 351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C 10.1021/acs.jmedchem.9b00742
CHEMBL4531005 1079 None 1 Human Functional pEC50 = 8.1 8.1 -1 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 1000 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 1000 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)
ChEMBL 351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C 10.1021/acs.jmedchem.9b00742
155491018 174187 None 1 Human Functional pEC50 = 8.1 8.1 2 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)
ChEMBL 395 3 2 5 3.1 CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 10.1021/acs.jmedchem.9b00742
CHEMBL4544504 174187 None 1 Human Functional pEC50 = 8.1 8.1 2 2
Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTPgammaS binding at 300 nM preincubated for 30 mins followed by [35S]GTPgammaS addition and measured after 90 mins (Rvb = 4 nM)
ChEMBL 395 3 2 5 3.1 CC(C)c1[nH]c2nc(N)nn2c(=O)c1Cc1ccc(Cl)c(Br)c1 10.1021/acs.jmedchem.9b00742
11151928 189596 None 0 Human Functional pED50 = 9.1 9.1 -10 4
Antagonist activity at CCR5 in human THP1 cells assessed as inhibition of CCL5-induced chemotaxis after 2 hrs by microtiter format trans-well migration assayAntagonist activity at CCR5 in human THP1 cells assessed as inhibition of CCL5-induced chemotaxis after 2 hrs by microtiter format trans-well migration assay
ChEMBL 338 11 2 2 4.3 CCCCCCCCCCC(C)(C)C(=O)N[C@H]1CCCCNC1=O 10.1021/jm900133w
CHEMBL513863 189596 None 0 Human Functional pED50 = 9.1 9.1 -10 4
Antagonist activity at CCR5 in human THP1 cells assessed as inhibition of CCL5-induced chemotaxis after 2 hrs by microtiter format trans-well migration assayAntagonist activity at CCR5 in human THP1 cells assessed as inhibition of CCL5-induced chemotaxis after 2 hrs by microtiter format trans-well migration assay
ChEMBL 338 11 2 2 4.3 CCCCCCCCCCC(C)(C)C(=O)N[C@H]1CCCCNC1=O 10.1021/jm900133w
15941255 81804 None 0 Human Functional pIC50 = 10.1 10.1 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 527 9 2 6 4.5 CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2Cl)CC1 10.1021/ml2002604
CHEMBL2164207 81804 None 0 Human Functional pIC50 = 10.1 10.1 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 527 9 2 6 4.5 CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2Cl)CC1 10.1021/ml2002604
57402801 69245 None 0 Human Functional pIC50 = 10.1 10.1 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 600 12 2 7 5.2 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(C(=O)NC(C)C)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
CHEMBL1926899 69245 None 0 Human Functional pIC50 = 10.1 10.1 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 600 12 2 7 5.2 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(C(=O)NC(C)C)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
50993591 57225 None 0 Human Functional pIC50 = 10 10.0 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 497 6 1 6 3.9 COC(=O)N1CCc2nc(C)n([C@@H]3C[C@@H]4CC[C@H](C3)N4CC[C@H](NC(C)=O)c3cccc(F)c3)c2C1 10.1021/jm100978n
CHEMBL1649924 57225 None 0 Human Functional pIC50 = 10 10.0 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 497 6 1 6 3.9 COC(=O)N1CCc2nc(C)n([C@@H]3C[C@@H]4CC[C@H](C3)N4CC[C@H](NC(C)=O)c3cccc(F)c3)c2C1 10.1021/jm100978n
15940800 81799 None 0 Human Functional pIC50 = 10 10.0 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 561 10 1 7 3.9 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)CN2CCOC2=O)CC1 10.1021/ml2002604
CHEMBL2164202 81799 None 0 Human Functional pIC50 = 10 10.0 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 561 10 1 7 3.9 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)CN2CCOC2=O)CC1 10.1021/ml2002604
15941086 81807 None 0 Human Functional pIC50 = 10 10.0 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 518 9 2 7 3.7 CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(C#N)nc2Cl)CC1 10.1021/ml2002604
CHEMBL2164210 81807 None 0 Human Functional pIC50 = 10 10.0 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 518 9 2 7 3.7 CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(C#N)nc2Cl)CC1 10.1021/ml2002604
11285792 879 None 32 Human Functional pIC50 = 10 10.0 -3 6
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 10.1021/jm0509703
801 879 None 32 Human Functional pIC50 = 10 10.0 -3 6
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 10.1021/jm0509703
CHEMBL2110727 879 None 32 Human Functional pIC50 = 10 10.0 -3 6
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 10.1021/jm0509703
DB11758 879 None 32 Human Functional pIC50 = 10 10.0 -3 6
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 10.1021/jm0509703
62706107 81814 None 0 Human Functional pIC50 = 10.0 10.0 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 554 9 2 6 5.5 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)Nc2cccnc2)CC1 10.1021/ml2002604
CHEMBL2164217 81814 None 0 Human Functional pIC50 = 10.0 10.0 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 554 9 2 6 5.5 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)Nc2cccnc2)CC1 10.1021/ml2002604
11650548 103597 None 0 Human Functional pIC50 = 9.7 9.7 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 697 17 1 8 8.1 CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4nncn4CCC)cc2)CCCN3CC(C)C)cc1 10.1021/jm0509703
CHEMBL3085308 103597 None 0 Human Functional pIC50 = 9.7 9.7 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 697 17 1 8 8.1 CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4nncn4CCC)cc2)CCCN3CC(C)C)cc1 10.1021/jm0509703
15947119 69239 None 0 Human Functional pIC50 = 9.7 9.7 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 549 10 1 6 5.7 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
CHEMBL1926893 69239 None 0 Human Functional pIC50 = 9.7 9.7 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 549 10 1 6 5.7 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
3002977 2460 None 43 Human Functional pIC50 = 9.7 9.7 2 4
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/jm100978n
3002977.0 2460 None 43 Human Functional pIC50 = 9.7 9.7 2 4
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/jm100978n
803 2460 None 43 Human Functional pIC50 = 9.7 9.7 2 4
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/jm100978n
806 2460 None 43 Human Functional pIC50 = 9.7 9.7 2 4
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/jm100978n
CHEMBL1201187 2460 None 43 Human Functional pIC50 = 9.7 9.7 2 4
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/jm100978n
CHEMBL256907 2460 None 43 Human Functional pIC50 = 9.7 9.7 2 4
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/jm100978n
CHEMBL584744 2460 None 43 Human Functional pIC50 = 9.7 9.7 2 4
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/jm100978n
DB04835 2460 None 43 Human Functional pIC50 = 9.7 9.7 2 4
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/jm100978n
50993593 57227 None 0 Human Functional pIC50 = 9.7 9.7 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 497 6 1 6 3.9 COC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(C)=O)CC3)C2)c1cccc(F)c1 10.1021/jm100978n
CHEMBL1649926 57227 None 0 Human Functional pIC50 = 9.7 9.7 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 497 6 1 6 3.9 COC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(C)=O)CC3)C2)c1cccc(F)c1 10.1021/jm100978n
50992494 57228 None 0 Human Functional pIC50 = 9.7 9.7 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 513 6 1 7 4.1 COC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(=O)OC)CC3)C2)c1cccc(F)c1 10.1021/jm100978n
CHEMBL1649927 57228 None 0 Human Functional pIC50 = 9.7 9.7 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 513 6 1 7 4.1 COC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(=O)OC)CC3)C2)c1cccc(F)c1 10.1021/jm100978n
3002977 2460 None 43 Human Functional pIC50 = 9.7 9.7 2 4
Inhibition of CCR5 in human TZM-bl cells infected with HIV1 Bal R5 assessed as antiviral activity by measuring reduction in viral infection pre-incubated with cells followed by viral infection measured after 3 days by luciferase reporter gene assayInhibition of CCR5 in human TZM-bl cells infected with HIV1 Bal R5 assessed as antiviral activity by measuring reduction in viral infection pre-incubated with cells followed by viral infection measured after 3 days by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmc.2016.12.035
3002977.0 2460 None 43 Human Functional pIC50 = 9.7 9.7 2 4
Inhibition of CCR5 in human TZM-bl cells infected with HIV1 Bal R5 assessed as antiviral activity by measuring reduction in viral infection pre-incubated with cells followed by viral infection measured after 3 days by luciferase reporter gene assayInhibition of CCR5 in human TZM-bl cells infected with HIV1 Bal R5 assessed as antiviral activity by measuring reduction in viral infection pre-incubated with cells followed by viral infection measured after 3 days by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmc.2016.12.035
803 2460 None 43 Human Functional pIC50 = 9.7 9.7 2 4
Inhibition of CCR5 in human TZM-bl cells infected with HIV1 Bal R5 assessed as antiviral activity by measuring reduction in viral infection pre-incubated with cells followed by viral infection measured after 3 days by luciferase reporter gene assayInhibition of CCR5 in human TZM-bl cells infected with HIV1 Bal R5 assessed as antiviral activity by measuring reduction in viral infection pre-incubated with cells followed by viral infection measured after 3 days by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmc.2016.12.035
806 2460 None 43 Human Functional pIC50 = 9.7 9.7 2 4
Inhibition of CCR5 in human TZM-bl cells infected with HIV1 Bal R5 assessed as antiviral activity by measuring reduction in viral infection pre-incubated with cells followed by viral infection measured after 3 days by luciferase reporter gene assayInhibition of CCR5 in human TZM-bl cells infected with HIV1 Bal R5 assessed as antiviral activity by measuring reduction in viral infection pre-incubated with cells followed by viral infection measured after 3 days by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmc.2016.12.035
CHEMBL1201187 2460 None 43 Human Functional pIC50 = 9.7 9.7 2 4
Inhibition of CCR5 in human TZM-bl cells infected with HIV1 Bal R5 assessed as antiviral activity by measuring reduction in viral infection pre-incubated with cells followed by viral infection measured after 3 days by luciferase reporter gene assayInhibition of CCR5 in human TZM-bl cells infected with HIV1 Bal R5 assessed as antiviral activity by measuring reduction in viral infection pre-incubated with cells followed by viral infection measured after 3 days by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmc.2016.12.035
CHEMBL256907 2460 None 43 Human Functional pIC50 = 9.7 9.7 2 4
Inhibition of CCR5 in human TZM-bl cells infected with HIV1 Bal R5 assessed as antiviral activity by measuring reduction in viral infection pre-incubated with cells followed by viral infection measured after 3 days by luciferase reporter gene assayInhibition of CCR5 in human TZM-bl cells infected with HIV1 Bal R5 assessed as antiviral activity by measuring reduction in viral infection pre-incubated with cells followed by viral infection measured after 3 days by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmc.2016.12.035
CHEMBL584744 2460 None 43 Human Functional pIC50 = 9.7 9.7 2 4
Inhibition of CCR5 in human TZM-bl cells infected with HIV1 Bal R5 assessed as antiviral activity by measuring reduction in viral infection pre-incubated with cells followed by viral infection measured after 3 days by luciferase reporter gene assayInhibition of CCR5 in human TZM-bl cells infected with HIV1 Bal R5 assessed as antiviral activity by measuring reduction in viral infection pre-incubated with cells followed by viral infection measured after 3 days by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmc.2016.12.035
DB04835 2460 None 43 Human Functional pIC50 = 9.7 9.7 2 4
Inhibition of CCR5 in human TZM-bl cells infected with HIV1 Bal R5 assessed as antiviral activity by measuring reduction in viral infection pre-incubated with cells followed by viral infection measured after 3 days by luciferase reporter gene assayInhibition of CCR5 in human TZM-bl cells infected with HIV1 Bal R5 assessed as antiviral activity by measuring reduction in viral infection pre-incubated with cells followed by viral infection measured after 3 days by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmc.2016.12.035
11285792 879 None 32 Human Functional pIC50 = 9.7 9.7 -3 6
Inhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cellsInhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cells
ChEMBL 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 10.1021/jm0509703
801 879 None 32 Human Functional pIC50 = 9.7 9.7 -3 6
Inhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cellsInhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cells
ChEMBL 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 10.1021/jm0509703
CHEMBL2110727 879 None 32 Human Functional pIC50 = 9.7 9.7 -3 6
Inhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cellsInhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cells
ChEMBL 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 10.1021/jm0509703
DB11758 879 None 32 Human Functional pIC50 = 9.7 9.7 -3 6
Inhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cellsInhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cells
ChEMBL 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 10.1021/jm0509703
11513274 103598 None 0 Human Functional pIC50 = 9.7 9.7 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 734 17 1 9 8.0 CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCN3Cc2cnn(C)c2)cc1 10.1021/jm0509703
CHEMBL3085309 103598 None 0 Human Functional pIC50 = 9.7 9.7 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 734 17 1 9 8.0 CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCN3Cc2cnn(C)c2)cc1 10.1021/jm0509703
9810893 103596 None 0 Human Functional pIC50 = 9.6 9.6 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 682 17 1 7 8.5 CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCN3CCC)cc1 10.1021/jm0509703
CHEMBL3085307 103596 None 0 Human Functional pIC50 = 9.6 9.6 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 682 17 1 7 8.5 CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCN3CCC)cc1 10.1021/jm0509703
44511934 69242 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 533 10 1 6 5.2 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(F)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
CHEMBL1926896 69242 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 533 10 1 6 5.2 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(F)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
44512090 69244 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 540 10 1 7 5.0 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(C#N)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
CHEMBL1926898 69244 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 540 10 1 7 5.0 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(C#N)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
44512058 69253 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 551 10 1 8 4.5 COc1ccc(N(Cc2cccc(C#N)n2)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(C#N)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
CHEMBL1927008 69253 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 551 10 1 8 4.5 COc1ccc(N(Cc2cccc(C#N)n2)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(C#N)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
44511938 69254 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 560 10 1 7 5.3 COc1ccc(N(Cc2cccc(C#N)n2)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
CHEMBL1927009 69254 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 560 10 1 7 5.3 COc1ccc(N(Cc2cccc(C#N)n2)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
50992641 57224 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 479 6 1 6 3.8 COC(=O)N1CCc2nc(C)n([C@@H]3C[C@@H]4CC[C@H](C3)N4CC[C@H](NC(C)=O)c3ccccc3)c2C1 10.1021/jm100978n
CHEMBL1649922 57224 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 479 6 1 6 3.8 COC(=O)N1CCc2nc(C)n([C@@H]3C[C@@H]4CC[C@H](C3)N4CC[C@H](NC(C)=O)c3ccccc3)c2C1 10.1021/jm100978n
62706110 81800 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 491 8 2 5 4.2 CNC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 10.1021/ml2002604
CHEMBL2164203 81800 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 491 8 2 5 4.2 CNC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 10.1021/ml2002604
15940799 81802 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 493 8 3 6 4.0 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)NO)CC1 10.1021/ml2002604
CHEMBL2164205 81802 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 493 8 3 6 4.0 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)NO)CC1 10.1021/ml2002604
57384005 81803 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 507 9 2 6 4.2 CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 10.1021/ml2002604
CHEMBL2164206 81803 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 507 9 2 6 4.2 CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 10.1021/ml2002604
57384006 81808 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 551 12 2 7 4.2 COCCONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 10.1021/ml2002604
CHEMBL2164211 81808 None 0 Human Functional pIC50 = 9.5 9.5 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 551 12 2 7 4.2 COCCONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 10.1021/ml2002604
50915506 19052 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 848 11 2 6 8.2 CC(C)(C)NS(=O)(=O)c1cc(C(=O)N2CCC(CCN3CCC(N(C(=O)NCc4ccc(C#N)cc4)c4cccc(F)c4)CC3)(c3cccc(F)c3)CC2)c(Cl)cc1F 10.1016/j.bmcl.2010.10.033
CHEMBL1288663 19052 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 848 11 2 6 8.2 CC(C)(C)NS(=O)(=O)c1cc(C(=O)N2CCC(CCN3CCC(N(C(=O)NCc4ccc(C#N)cc4)c4cccc(F)c4)CC3)(c3cccc(F)c3)CC2)c(Cl)cc1F 10.1016/j.bmcl.2010.10.033
44455217 95472 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at CCR5 receptor by [35S]GTP-gamma-S binding assayAntagonist activity at CCR5 receptor by [35S]GTP-gamma-S binding assay
ChEMBL 608 7 1 5 6.4 CC(=O)N1CCc2c(nc(C)n2[C@H]2C[C@@H]3CC[C@H](C2)N3CCCN(C(=O)Nc2ccc(C(F)(F)F)cc2)c2ccccc2)C1 10.1016/j.bmcl.2007.12.058
CHEMBL257000 95472 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at CCR5 receptor by [35S]GTP-gamma-S binding assayAntagonist activity at CCR5 receptor by [35S]GTP-gamma-S binding assay
ChEMBL 608 7 1 5 6.4 CC(=O)N1CCc2c(nc(C)n2[C@H]2C[C@@H]3CC[C@H](C2)N3CCCN(C(=O)Nc2ccc(C(F)(F)F)cc2)c2ccccc2)C1 10.1016/j.bmcl.2007.12.058
50992577 57220 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 463 6 1 5 3.5 CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(C)=O)CC3)C2)c1ccccc1 10.1021/jm100978n
CHEMBL1649919 57220 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 463 6 1 5 3.5 CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(C)=O)CC3)C2)c1ccccc1 10.1021/jm100978n
50992639 57222 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 477 7 1 5 3.9 CCC(=O)N1CCc2nc(C)n([C@@H]3C[C@@H]4CC[C@H](C3)N4CC[C@H](NC(C)=O)c3ccccc3)c2C1 10.1021/jm100978n
CHEMBL1649920 57222 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 477 7 1 5 3.9 CCC(=O)N1CCc2nc(C)n([C@@H]3C[C@@H]4CC[C@H](C3)N4CC[C@H](NC(C)=O)c3ccccc3)c2C1 10.1021/jm100978n
50992640 57223 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 491 7 1 5 4.2 CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(=O)C(C)C)CC3)C2)c1ccccc1 10.1021/jm100978n
CHEMBL1649921 57223 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 491 7 1 5 4.2 CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(=O)C(C)C)CC3)C2)c1ccccc1 10.1021/jm100978n
59458228 81805 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 558 11 3 7 3.6 CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(C(=O)NC(C)C)nc2C)CC1 10.1021/ml2002604
CHEMBL2164208 81805 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 558 11 3 7 3.6 CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(C(=O)NC(C)C)nc2C)CC1 10.1021/ml2002604
59458061 81806 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 543 9 2 6 3.7 CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)[n+]([O-])c2Cl)CC1 10.1021/ml2002604
CHEMBL2164209 81806 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 543 9 2 6 3.7 CONC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)[n+]([O-])c2Cl)CC1 10.1021/ml2002604
15941083 81816 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 506 10 1 6 4.1 COCC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 10.1021/ml2002604
CHEMBL2164219 81816 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 506 10 1 6 4.1 COCC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 10.1021/ml2002604
15940801 81817 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 501 9 1 6 4.3 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)CC#N)CC1 10.1021/ml2002604
CHEMBL2164220 81817 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 501 9 1 6 4.3 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)CC#N)CC1 10.1021/ml2002604
5275766 3738 None 34 Human Functional pIC50 = 9.4 9.4 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 552 9 1 4 4.7 CC(=O)N1CCC(CC1)C(=O)N(c1ccc(c(c1)Cl)C)CCCN1CCC(CC1)Cc1ccc(cc1)C(=O)N 10.1021/jm051034q
800 3738 None 34 Human Functional pIC50 = 9.4 9.4 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 552 9 1 4 4.7 CC(=O)N1CCC(CC1)C(=O)N(c1ccc(c(c1)Cl)C)CCCN1CCC(CC1)Cc1ccc(cc1)C(=O)N 10.1021/jm051034q
CHEMBL207004 3738 None 34 Human Functional pIC50 = 9.4 9.4 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 552 9 1 4 4.7 CC(=O)N1CCC(CC1)C(=O)N(c1ccc(c(c1)Cl)C)CCCN1CCC(CC1)Cc1ccc(cc1)C(=O)N 10.1021/jm051034q
11700429 103600 None 0 Human Functional pIC50 = 9.3 9.3 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 710 17 1 7 9.1 CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCCN3CC(C)C)cc1 10.1021/jm0509703
CHEMBL3085311 103600 None 0 Human Functional pIC50 = 9.3 9.3 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 710 17 1 7 9.1 CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCCN3CC(C)C)cc1 10.1021/jm0509703
53325983 57214 None 0 Human Functional pIC50 = 9.3 9.3 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 416 6 1 4 4.8 CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3ccccc31)C2)c1ccccc1 10.1021/jm100978n
CHEMBL1649913 57214 None 0 Human Functional pIC50 = 9.3 9.3 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 416 6 1 4 4.8 CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3ccccc31)C2)c1ccccc1 10.1021/jm100978n
15940498 81809 None 0 Human Functional pIC50 = 9.3 9.3 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 611 11 3 6 5.5 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)NCc2ccc(C(=O)O)cc2)CC1 10.1021/ml2002604
CHEMBL2164212 81809 None 0 Human Functional pIC50 = 9.3 9.3 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 611 11 3 6 5.5 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)NCc2ccc(C(=O)O)cc2)CC1 10.1021/ml2002604
457871 100777 None 0 Human Functional pIC50 = 9.3 9.3 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 483 4 1 3 5.6 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(Br)cc3)CC2)CC1 10.1021/jm031046g
CHEMBL292625 100777 None 0 Human Functional pIC50 = 9.3 9.3 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 483 4 1 3 5.6 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(Br)cc3)CC2)CC1 10.1021/jm031046g
44511935 69246 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 593 13 1 7 5.8 COCCOc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
CHEMBL1926900 69246 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 593 13 1 7 5.8 COCCOc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
50993592 57226 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 479 6 1 6 3.8 COC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(C)=O)CC3)C2)c1ccccc1 10.1021/jm100978n
CHEMBL1649925 57226 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 479 6 1 6 3.8 COC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(C)=O)CC3)C2)c1ccccc1 10.1021/jm100978n
3008904 202422 None 0 Human Functional pIC50 = 9.2 9.2 1 2
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 537 6 0 5 5.0 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3cccc(C#N)c3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL59511 202422 None 0 Human Functional pIC50 = 9.2 9.2 1 2
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 537 6 0 5 5.0 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3cccc(C#N)c3)c3ccccc3)CC2)CC1 10.1021/jm031046g
11614352 550 None 1 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at CCR5 in allo T cells assessed as inhibition of MIP-1beta-induced chemotaxisAntagonist activity at CCR5 in allo T cells assessed as inhibition of MIP-1beta-induced chemotaxis
ChEMBL 639 11 0 6 4.1 CCN(C(=O)Cc1ccc(cc1)S(=O)(=O)C)C1CCN(CC1)CC[C@@H](c1cc(F)cc(c1)F)C1CCN(CC1)S(=O)(=O)C 10.1016/j.bmcl.2011.12.117
7686 550 None 1 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at CCR5 in allo T cells assessed as inhibition of MIP-1beta-induced chemotaxisAntagonist activity at CCR5 in allo T cells assessed as inhibition of MIP-1beta-induced chemotaxis
ChEMBL 639 11 0 6 4.1 CCN(C(=O)Cc1ccc(cc1)S(=O)(=O)C)C1CCN(CC1)CC[C@@H](c1cc(F)cc(c1)F)C1CCN(CC1)S(=O)(=O)C 10.1016/j.bmcl.2011.12.117
CHEMBL1951914 550 None 1 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at CCR5 in allo T cells assessed as inhibition of MIP-1beta-induced chemotaxisAntagonist activity at CCR5 in allo T cells assessed as inhibition of MIP-1beta-induced chemotaxis
ChEMBL 639 11 0 6 4.1 CCN(C(=O)Cc1ccc(cc1)S(=O)(=O)C)C1CCN(CC1)CC[C@@H](c1cc(F)cc(c1)F)C1CCN(CC1)S(=O)(=O)C 10.1016/j.bmcl.2011.12.117
57392303 69237 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 535 10 1 6 5.4 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)ccnc3Cl)CC2)cc1 10.1016/j.bmcl.2011.09.133
CHEMBL1926891 69237 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 535 10 1 6 5.4 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)ccnc3Cl)CC2)cc1 10.1016/j.bmcl.2011.09.133
44512001 69255 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 544 10 1 7 4.8 COc1ccc(N(Cc2cccc(C#N)n2)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(F)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
CHEMBL1927010 69255 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 544 10 1 7 4.8 COc1ccc(N(Cc2cccc(C#N)n2)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(F)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
62706106 81812 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 560 10 1 6 5.2 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)CC2CCOCC2)CC1 10.1021/ml2002604
CHEMBL2164215 81812 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 560 10 1 6 5.2 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)CC2CCOCC2)CC1 10.1021/ml2002604
3008917 205241 None 3 Human Functional pIC50 = 9.2 9.2 -6 2
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 481 5 0 3 6.6 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL62152 205241 None 3 Human Functional pIC50 = 9.2 9.2 -6 2
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 481 5 0 3 6.6 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
23725098 195909 None 4 Human Functional pIC50 = 9.1 9.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 60 mins by Fluo-4 AM calcium flux based FLIPR assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 60 mins by Fluo-4 AM calcium flux based FLIPR assay
ChEMBL 513 8 1 5 6.0 Cc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1 10.1016/j.ejmech.2023.115294
CHEMBL5413158 195909 None 4 Human Functional pIC50 = 9.1 9.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 60 mins by Fluo-4 AM calcium flux based FLIPR assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 60 mins by Fluo-4 AM calcium flux based FLIPR assay
ChEMBL 513 8 1 5 6.0 Cc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1 10.1016/j.ejmech.2023.115294
3002977 2460 None 43 Human Functional pIC50 = 9.1 9.1 2 4
Antagonist activity at CCR5 (unknown origin) expressed in HOS cells co-expressing Gqi-5 assessed as inhibition CCL5-stimulated Ca2+ mobilization by calcium mobilization assayAntagonist activity at CCR5 (unknown origin) expressed in HOS cells co-expressing Gqi-5 assessed as inhibition CCL5-stimulated Ca2+ mobilization by calcium mobilization assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.1c00408
3002977.0 2460 None 43 Human Functional pIC50 = 9.1 9.1 2 4
Antagonist activity at CCR5 (unknown origin) expressed in HOS cells co-expressing Gqi-5 assessed as inhibition CCL5-stimulated Ca2+ mobilization by calcium mobilization assayAntagonist activity at CCR5 (unknown origin) expressed in HOS cells co-expressing Gqi-5 assessed as inhibition CCL5-stimulated Ca2+ mobilization by calcium mobilization assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.1c00408
803 2460 None 43 Human Functional pIC50 = 9.1 9.1 2 4
Antagonist activity at CCR5 (unknown origin) expressed in HOS cells co-expressing Gqi-5 assessed as inhibition CCL5-stimulated Ca2+ mobilization by calcium mobilization assayAntagonist activity at CCR5 (unknown origin) expressed in HOS cells co-expressing Gqi-5 assessed as inhibition CCL5-stimulated Ca2+ mobilization by calcium mobilization assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.1c00408
806 2460 None 43 Human Functional pIC50 = 9.1 9.1 2 4
Antagonist activity at CCR5 (unknown origin) expressed in HOS cells co-expressing Gqi-5 assessed as inhibition CCL5-stimulated Ca2+ mobilization by calcium mobilization assayAntagonist activity at CCR5 (unknown origin) expressed in HOS cells co-expressing Gqi-5 assessed as inhibition CCL5-stimulated Ca2+ mobilization by calcium mobilization assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.1c00408
CHEMBL1201187 2460 None 43 Human Functional pIC50 = 9.1 9.1 2 4
Antagonist activity at CCR5 (unknown origin) expressed in HOS cells co-expressing Gqi-5 assessed as inhibition CCL5-stimulated Ca2+ mobilization by calcium mobilization assayAntagonist activity at CCR5 (unknown origin) expressed in HOS cells co-expressing Gqi-5 assessed as inhibition CCL5-stimulated Ca2+ mobilization by calcium mobilization assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.1c00408
CHEMBL256907 2460 None 43 Human Functional pIC50 = 9.1 9.1 2 4
Antagonist activity at CCR5 (unknown origin) expressed in HOS cells co-expressing Gqi-5 assessed as inhibition CCL5-stimulated Ca2+ mobilization by calcium mobilization assayAntagonist activity at CCR5 (unknown origin) expressed in HOS cells co-expressing Gqi-5 assessed as inhibition CCL5-stimulated Ca2+ mobilization by calcium mobilization assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.1c00408
CHEMBL584744 2460 None 43 Human Functional pIC50 = 9.1 9.1 2 4
Antagonist activity at CCR5 (unknown origin) expressed in HOS cells co-expressing Gqi-5 assessed as inhibition CCL5-stimulated Ca2+ mobilization by calcium mobilization assayAntagonist activity at CCR5 (unknown origin) expressed in HOS cells co-expressing Gqi-5 assessed as inhibition CCL5-stimulated Ca2+ mobilization by calcium mobilization assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.1c00408
DB04835 2460 None 43 Human Functional pIC50 = 9.1 9.1 2 4
Antagonist activity at CCR5 (unknown origin) expressed in HOS cells co-expressing Gqi-5 assessed as inhibition CCL5-stimulated Ca2+ mobilization by calcium mobilization assayAntagonist activity at CCR5 (unknown origin) expressed in HOS cells co-expressing Gqi-5 assessed as inhibition CCL5-stimulated Ca2+ mobilization by calcium mobilization assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.1c00408
44511871 69247 None 0 Human Functional pIC50 = 9.1 9.1 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 584 13 1 8 5.0 COCCOc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(C#N)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
CHEMBL1926901 69247 None 0 Human Functional pIC50 = 9.1 9.1 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 584 13 1 8 5.0 COCCOc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(C#N)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
72711958 92708 None 0 Human Functional pIC50 = 9.1 9.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 574 9 1 5 5.4 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(Cc3ccncc3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
CHEMBL2435864 92708 None 0 Human Functional pIC50 = 9.1 9.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 574 9 1 5 5.4 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(Cc3ccncc3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
72711740 92753 None 0 Human Functional pIC50 = 9.1 9.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 581 9 1 5 5.2 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(CC3CCOCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
CHEMBL2435909 92753 None 0 Human Functional pIC50 = 9.1 9.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 581 9 1 5 5.2 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(CC3CCOCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
62706109 81798 None 0 Human Functional pIC50 = 9.1 9.1 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 551 10 1 7 4.5 Cc1cc(C#N)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)CC2CCOCC2)CC1 10.1021/ml2002604
CHEMBL2164201 81798 None 0 Human Functional pIC50 = 9.1 9.1 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 551 10 1 7 4.5 Cc1cc(C#N)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)CC2CCOCC2)CC1 10.1021/ml2002604
3008909 201556 None 0 Human Functional pIC50 = 9.1 9.1 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 473 4 1 3 5.9 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(C(F)(F)F)cc3)CC2)CC1 10.1021/jm031046g
CHEMBL58897 201556 None 0 Human Functional pIC50 = 9.1 9.1 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 473 4 1 3 5.9 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(C(F)(F)F)cc3)CC2)CC1 10.1021/jm031046g
3013701 77122 None 0 Human Functional pIC50 = 9.1 9.1 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 643 10 0 6 4.7 CS(=O)(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(S(C)(=O)=O)CC3)c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1021/jm051034q
CHEMBL207487 77122 None 0 Human Functional pIC50 = 9.1 9.1 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 643 10 0 6 4.7 CS(=O)(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(S(C)(=O)=O)CC3)c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1021/jm051034q
3002977 2460 None 43 Human Functional pIC50 = 9.1 9.1 2 4
Antagonist activity at human CCR5 receptor expressed in HEK293 cells co-expressing Galpha15 assessed as inhibition of RNATES-induced intracellular calcium flux measured after 10 mins by FLIPR calcium mobilization assayAntagonist activity at human CCR5 receptor expressed in HEK293 cells co-expressing Galpha15 assessed as inhibition of RNATES-induced intracellular calcium flux measured after 10 mins by FLIPR calcium mobilization assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.1c00781
3002977.0 2460 None 43 Human Functional pIC50 = 9.1 9.1 2 4
Antagonist activity at human CCR5 receptor expressed in HEK293 cells co-expressing Galpha15 assessed as inhibition of RNATES-induced intracellular calcium flux measured after 10 mins by FLIPR calcium mobilization assayAntagonist activity at human CCR5 receptor expressed in HEK293 cells co-expressing Galpha15 assessed as inhibition of RNATES-induced intracellular calcium flux measured after 10 mins by FLIPR calcium mobilization assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.1c00781
803 2460 None 43 Human Functional pIC50 = 9.1 9.1 2 4
Antagonist activity at human CCR5 receptor expressed in HEK293 cells co-expressing Galpha15 assessed as inhibition of RNATES-induced intracellular calcium flux measured after 10 mins by FLIPR calcium mobilization assayAntagonist activity at human CCR5 receptor expressed in HEK293 cells co-expressing Galpha15 assessed as inhibition of RNATES-induced intracellular calcium flux measured after 10 mins by FLIPR calcium mobilization assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.1c00781
806 2460 None 43 Human Functional pIC50 = 9.1 9.1 2 4
Antagonist activity at human CCR5 receptor expressed in HEK293 cells co-expressing Galpha15 assessed as inhibition of RNATES-induced intracellular calcium flux measured after 10 mins by FLIPR calcium mobilization assayAntagonist activity at human CCR5 receptor expressed in HEK293 cells co-expressing Galpha15 assessed as inhibition of RNATES-induced intracellular calcium flux measured after 10 mins by FLIPR calcium mobilization assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.1c00781
CHEMBL1201187 2460 None 43 Human Functional pIC50 = 9.1 9.1 2 4
Antagonist activity at human CCR5 receptor expressed in HEK293 cells co-expressing Galpha15 assessed as inhibition of RNATES-induced intracellular calcium flux measured after 10 mins by FLIPR calcium mobilization assayAntagonist activity at human CCR5 receptor expressed in HEK293 cells co-expressing Galpha15 assessed as inhibition of RNATES-induced intracellular calcium flux measured after 10 mins by FLIPR calcium mobilization assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.1c00781
CHEMBL256907 2460 None 43 Human Functional pIC50 = 9.1 9.1 2 4
Antagonist activity at human CCR5 receptor expressed in HEK293 cells co-expressing Galpha15 assessed as inhibition of RNATES-induced intracellular calcium flux measured after 10 mins by FLIPR calcium mobilization assayAntagonist activity at human CCR5 receptor expressed in HEK293 cells co-expressing Galpha15 assessed as inhibition of RNATES-induced intracellular calcium flux measured after 10 mins by FLIPR calcium mobilization assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.1c00781
CHEMBL584744 2460 None 43 Human Functional pIC50 = 9.1 9.1 2 4
Antagonist activity at human CCR5 receptor expressed in HEK293 cells co-expressing Galpha15 assessed as inhibition of RNATES-induced intracellular calcium flux measured after 10 mins by FLIPR calcium mobilization assayAntagonist activity at human CCR5 receptor expressed in HEK293 cells co-expressing Galpha15 assessed as inhibition of RNATES-induced intracellular calcium flux measured after 10 mins by FLIPR calcium mobilization assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.1c00781
DB04835 2460 None 43 Human Functional pIC50 = 9.1 9.1 2 4
Antagonist activity at human CCR5 receptor expressed in HEK293 cells co-expressing Galpha15 assessed as inhibition of RNATES-induced intracellular calcium flux measured after 10 mins by FLIPR calcium mobilization assayAntagonist activity at human CCR5 receptor expressed in HEK293 cells co-expressing Galpha15 assessed as inhibition of RNATES-induced intracellular calcium flux measured after 10 mins by FLIPR calcium mobilization assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.1c00781
5275766 3738 None 34 Human Functional pIC50 = 9.1 9.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 60 mins by Fluo-4 AM calcium flux based FLIPR assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 60 mins by Fluo-4 AM calcium flux based FLIPR assay
ChEMBL 552 9 1 4 4.7 CC(=O)N1CCC(CC1)C(=O)N(c1ccc(c(c1)Cl)C)CCCN1CCC(CC1)Cc1ccc(cc1)C(=O)N 10.1016/j.ejmech.2023.115294
800 3738 None 34 Human Functional pIC50 = 9.1 9.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 60 mins by Fluo-4 AM calcium flux based FLIPR assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 60 mins by Fluo-4 AM calcium flux based FLIPR assay
ChEMBL 552 9 1 4 4.7 CC(=O)N1CCC(CC1)C(=O)N(c1ccc(c(c1)Cl)C)CCCN1CCC(CC1)Cc1ccc(cc1)C(=O)N 10.1016/j.ejmech.2023.115294
CHEMBL207004 3738 None 34 Human Functional pIC50 = 9.1 9.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 60 mins by Fluo-4 AM calcium flux based FLIPR assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 60 mins by Fluo-4 AM calcium flux based FLIPR assay
ChEMBL 552 9 1 4 4.7 CC(=O)N1CCC(CC1)C(=O)N(c1ccc(c(c1)Cl)C)CCCN1CCC(CC1)Cc1ccc(cc1)C(=O)N 10.1016/j.ejmech.2023.115294
72711739 92751 None 0 Human Functional pIC50 = 9.1 9.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 551 8 1 4 5.7 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
CHEMBL2435907 92751 None 0 Human Functional pIC50 = 9.1 9.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 551 8 1 4 5.7 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
62706108 81815 None 0 Human Functional pIC50 = 9.1 9.1 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 476 8 1 5 4.4 CC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 10.1021/ml2002604
CHEMBL2164218 81815 None 0 Human Functional pIC50 = 9.1 9.1 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 476 8 1 5 4.4 CC(=O)N(Cc1ccsc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 10.1021/ml2002604
11636141 103599 None 0 Human Functional pIC50 = 9.0 9.0 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 683 17 1 8 7.9 CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4nncn4CCC)cc2)CCCN3CCC)cc1 10.1021/jm0509703
CHEMBL3085310 103599 None 0 Human Functional pIC50 = 9.0 9.0 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 683 17 1 8 7.9 CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4nncn4CCC)cc2)CCCN3CCC)cc1 10.1021/jm0509703
57402802 69250 None 0 Human Functional pIC50 = 9.0 9.0 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 583 12 2 8 3.8 Cc1ccncc1CN(c1ccc(OCC(N)=O)cc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(C#N)nc2C)CC1 10.1016/j.bmcl.2011.09.133
CHEMBL1926904 69250 None 0 Human Functional pIC50 = 9.0 9.0 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 583 12 2 8 3.8 Cc1ccncc1CN(c1ccc(OCC(N)=O)cc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(C#N)nc2C)CC1 10.1016/j.bmcl.2011.09.133
46225532 202129 None 0 Human Functional pIC50 = 9 9.0 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 547 6 0 5 3.8 Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL593042 202129 None 0 Human Functional pIC50 = 9 9.0 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 547 6 0 5 3.8 Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
3008928 205114 None 0 Human Functional pIC50 = 9 9.0 -1 2
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 483 5 0 5 5.4 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL61424 205114 None 0 Human Functional pIC50 = 9 9.0 -1 2
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 483 5 0 5 5.4 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
3013575 75797 None 0 Human Functional pIC50 = 9 9.0 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 682 17 1 7 8.4 CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc([S+]([O-])Cc4cncn4CCC)cc2)CCN3CC(C)C)cc1 10.1021/jm0509703
CHEMBL204821 75797 None 0 Human Functional pIC50 = 9 9.0 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 682 17 1 7 8.4 CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc([S+]([O-])Cc4cncn4CCC)cc2)CCN3CC(C)C)cc1 10.1021/jm0509703
73331746 197087 None 0 Human Functional pIC50 = 9.0 9.0 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 60 mins by Fluo-4 AM calcium flux based FLIPR assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 60 mins by Fluo-4 AM calcium flux based FLIPR assay
ChEMBL 618 9 1 5 4.7 CC(=O)N1CCC(C(=O)N(CCCN2C3CCC2CC(NS(=O)(=O)c2ccc(F)cc2)C3)c2ccc(C)c(Cl)c2)CC1 10.1016/j.ejmech.2023.115294
CHEMBL5438380 197087 None 0 Human Functional pIC50 = 9.0 9.0 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 60 mins by Fluo-4 AM calcium flux based FLIPR assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 60 mins by Fluo-4 AM calcium flux based FLIPR assay
ChEMBL 618 9 1 5 4.7 CC(=O)N1CCC(C(=O)N(CCCN2C3CCC2CC(NS(=O)(=O)c2ccc(F)cc2)C3)c2ccc(C)c(Cl)c2)CC1 10.1016/j.ejmech.2023.115294
49798082 10824 None 0 Human Functional pIC50 = 9.0 9.0 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 579 9 1 5 5.5 C=CCN(C(=O)OCc1ccc(Cl)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172043 10824 None 0 Human Functional pIC50 = 9.0 9.0 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 579 9 1 5 5.5 C=CCN(C(=O)OCc1ccc(Cl)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
44194590 10829 None 0 Human Functional pIC50 = 9.0 9.0 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 612 9 2 4 5.4 C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172048 10829 None 0 Human Functional pIC50 = 9.0 9.0 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 612 9 2 4 5.4 C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
11353001 58825 None 0 Human Functional pIC50 = 9.0 9.0 - 1
Antagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxisAntagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxis
ChEMBL 525 3 0 5 4.5 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN(C3CCc4cc(Br)ccc43)[C@@H](C)C2)CC1 10.1021/ml1001536
CHEMBL1688239 58825 None 0 Human Functional pIC50 = 9.0 9.0 - 1
Antagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxisAntagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxis
ChEMBL 525 3 0 5 4.5 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN(C3CCc4cc(Br)ccc43)[C@@H](C)C2)CC1 10.1021/ml1001536
11597 674 None 6 Human Functional pIC50 = 9.0 9.0 -11 2
Antagonist activity at CCR5 in human peripheral T cells assessed as reduction in MIP-1beta-induced chemotaxisAntagonist activity at CCR5 in human peripheral T cells assessed as reduction in MIP-1beta-induced chemotaxis
ChEMBL 506 5 3 6 3.5 CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C 10.1021/acsmedchemlett.1c00373
23725180 674 None 6 Human Functional pIC50 = 9.0 9.0 -11 2
Antagonist activity at CCR5 in human peripheral T cells assessed as reduction in MIP-1beta-induced chemotaxisAntagonist activity at CCR5 in human peripheral T cells assessed as reduction in MIP-1beta-induced chemotaxis
ChEMBL 506 5 3 6 3.5 CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C 10.1021/acsmedchemlett.1c00373
CHEMBL4781426 674 None 6 Human Functional pIC50 = 9.0 9.0 -11 2
Antagonist activity at CCR5 in human peripheral T cells assessed as reduction in MIP-1beta-induced chemotaxisAntagonist activity at CCR5 in human peripheral T cells assessed as reduction in MIP-1beta-induced chemotaxis
ChEMBL 506 5 3 6 3.5 CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C 10.1021/acsmedchemlett.1c00373
51039119 176321 None 34 Human Functional pIC50 = 9.0 9.0 1 3
Antagonist activity at CCR5 in human peripheral T cells assessed as reduction in MIP-1beta-induced chemotaxisAntagonist activity at CCR5 in human peripheral T cells assessed as reduction in MIP-1beta-induced chemotaxis
ChEMBL 484 5 3 8 2.2 CC(=O)N[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1N1CC[C@H](Nc2ncnc3cc(C(C)(C)C)nn23)C1=O 10.1021/acsmedchemlett.1c00373
CHEMBL4594419 176321 None 34 Human Functional pIC50 = 9.0 9.0 1 3
Antagonist activity at CCR5 in human peripheral T cells assessed as reduction in MIP-1beta-induced chemotaxisAntagonist activity at CCR5 in human peripheral T cells assessed as reduction in MIP-1beta-induced chemotaxis
ChEMBL 484 5 3 8 2.2 CC(=O)N[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1N1CC[C@H](Nc2ncnc3cc(C(C)(C)C)nn23)C1=O 10.1021/acsmedchemlett.1c00373
3008927 201314 None 0 Human Functional pIC50 = 9.0 9.0 -2 2
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 482 5 0 4 6.0 Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL58387 201314 None 0 Human Functional pIC50 = 9.0 9.0 -2 2
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 482 5 0 4 6.0 Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
3008909 201556 None 0 Human Functional pIC50 = 9.0 9.0 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 473 4 1 3 5.9 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(C(F)(F)F)cc3)CC2)CC1 10.1021/jm031046g
CHEMBL58897 201556 None 0 Human Functional pIC50 = 9.0 9.0 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 473 4 1 3 5.9 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(C(F)(F)F)cc3)CC2)CC1 10.1021/jm031046g
72711956 92706 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 588 9 1 5 5.7 Cc1ccncc1CN1C[C@@H](c2ccccc2)N(C2CCN(C(C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)C1=O 10.1021/jm401101p
CHEMBL2435862 92706 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 588 9 1 5 5.7 Cc1ccncc1CN1C[C@@H](c2ccccc2)N(C2CCN(C(C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)C1=O 10.1021/jm401101p
3009355 3989 None 18 Human Functional pIC50 = 8.9 8.9 -1 2
Antagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxisAntagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxis
ChEMBL 533 6 0 6 4.5 COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F 10.1021/ml1001536
807 3989 None 18 Human Functional pIC50 = 8.9 8.9 -1 2
Antagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxisAntagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxis
ChEMBL 533 6 0 6 4.5 COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F 10.1021/ml1001536
CHEMBL82301 3989 None 18 Human Functional pIC50 = 8.9 8.9 -1 2
Antagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxisAntagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxis
ChEMBL 533 6 0 6 4.5 COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F 10.1021/ml1001536
DB06652 3989 None 18 Human Functional pIC50 = 8.9 8.9 -1 2
Antagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxisAntagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxis
ChEMBL 533 6 0 6 4.5 COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F 10.1021/ml1001536
11605997 58827 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Antagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxisAntagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxis
ChEMBL 515 3 0 5 4.8 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN(C3CCc4cc(C(F)(F)F)ccc43)[C@@H](C)C2)CC1 10.1021/ml1001536
CHEMBL1688240 58827 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Antagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxisAntagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxis
ChEMBL 515 3 0 5 4.8 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN(C3CCc4cc(C(F)(F)F)ccc43)[C@@H](C)C2)CC1 10.1021/ml1001536
71458736 81810 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 507 10 1 7 4.8 COc1ccc(N(Cc2ccsc2)C2CCN([C@H](C)CCNC(=O)c3c(C)ncnc3C)CC2)cc1 10.1021/ml2002604
CHEMBL2164213 81810 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 507 10 1 7 4.8 COc1ccc(N(Cc2ccsc2)C2CCN([C@H](C)CCNC(=O)c3c(C)ncnc3C)CC2)cc1 10.1021/ml2002604
183790 3742 None 8 Human Functional pIC50 = 8.9 8.9 -2 5
Inhibition of chemotactic protein to CCR5Inhibition of chemotactic protein to CCR5
ChEMBL 495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C 10.1021/jm010468s
783 3742 None 8 Human Functional pIC50 = 8.9 8.9 -2 5
Inhibition of chemotactic protein to CCR5Inhibition of chemotactic protein to CCR5
ChEMBL 495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C 10.1021/jm010468s
CHEMBL1178786 3742 None 8 Human Functional pIC50 = 8.9 8.9 -2 5
Inhibition of chemotactic protein to CCR5Inhibition of chemotactic protein to CCR5
ChEMBL 495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C 10.1021/jm010468s
44512349 69248 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 577 13 1 7 5.2 COCCOc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(F)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
CHEMBL1926902 69248 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 577 13 1 7 5.2 COCCOc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(F)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
72711742 92704 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 573 9 1 4 6.0 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(Cc3ccccc3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
CHEMBL2435860 92704 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 573 9 1 4 6.0 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(Cc3ccccc3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
49864971 15790 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 630 9 2 4 5.5 C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2cccc(F)c2)CC1 10.1016/j.bmcl.2010.05.046
CHEMBL1222769 15790 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 630 9 2 4 5.5 C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2cccc(F)c2)CC1 10.1016/j.bmcl.2010.05.046
49768863 57213 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 Cc1nc(C(C)C)n([C@@H]2C[C@@H]3CC[C@H](C2)N3CC[C@H](NC(=O)C2CCC(F)(F)CC2)c2ccccc2)n1 10.1021/jm100978n
CHEMBL1649912 57213 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 Cc1nc(C(C)C)n([C@@H]2C[C@@H]3CC[C@H](C2)N3CC[C@H](NC(=O)C2CCC(F)(F)CC2)c2ccccc2)n1 10.1021/jm100978n
3008913 102031 None 0 Human Functional pIC50 = 8.9 8.9 -1 2
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 495 6 0 3 6.5 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL301454 102031 None 0 Human Functional pIC50 = 8.9 8.9 -1 2
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 495 6 0 3 6.5 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
183790 3742 None 8 Human Functional pIC50 = 8.9 8.9 -2 5
Compound was evaluated for the antagonist activity against C-C chemokine receptor type 5Compound was evaluated for the antagonist activity against C-C chemokine receptor type 5
ChEMBL 495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C 10.1016/s0960-894x(00)00347-4
783 3742 None 8 Human Functional pIC50 = 8.9 8.9 -2 5
Compound was evaluated for the antagonist activity against C-C chemokine receptor type 5Compound was evaluated for the antagonist activity against C-C chemokine receptor type 5
ChEMBL 495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C 10.1016/s0960-894x(00)00347-4
CHEMBL1178786 3742 None 8 Human Functional pIC50 = 8.9 8.9 -2 5
Compound was evaluated for the antagonist activity against C-C chemokine receptor type 5Compound was evaluated for the antagonist activity against C-C chemokine receptor type 5
ChEMBL 495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C 10.1016/s0960-894x(00)00347-4
183790 3742 None 8 Human Functional pIC50 = 8.9 8.9 -2 5
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C 10.1021/jm0509703
783 3742 None 8 Human Functional pIC50 = 8.9 8.9 -2 5
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C 10.1021/jm0509703
CHEMBL1178786 3742 None 8 Human Functional pIC50 = 8.9 8.9 -2 5
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C 10.1021/jm0509703
5275759 77145 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 590 9 0 5 5.2 CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(C#N)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
CHEMBL207630 77145 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 590 9 0 5 5.2 CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(C#N)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
9810893 103596 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Inhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cellsInhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cells
ChEMBL 682 17 1 7 8.5 CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCN3CCC)cc1 10.1021/jm0509703
CHEMBL3085307 103596 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Inhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cellsInhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cells
ChEMBL 682 17 1 7 8.5 CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCN3CCC)cc1 10.1021/jm0509703
CHEMBL5084989 217430 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at human CCR5 receptor expressed in HEK293 cells co-expressing Galpha15 assessed as inhibition of RNATES-induced intracellular calcium flux measured after 10 mins by FLIPR calcium mobilization assayAntagonist activity at human CCR5 receptor expressed in HEK293 cells co-expressing Galpha15 assessed as inhibition of RNATES-induced intracellular calcium flux measured after 10 mins by FLIPR calcium mobilization assay
ChEMBL None None None CC(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(C(=O)O)cc3)CC2)c2ccc(C)c(Cl)c2)CC1 10.1021/acs.jmedchem.1c00781
57395817 69240 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 535 10 1 6 5.4 COc1ccc(N(Cc2cccnc2)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
CHEMBL1926894 69240 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 535 10 1 6 5.4 COc1ccc(N(Cc2cccnc2)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
72714078 92729 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 565 8 1 4 6.1 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
CHEMBL2435885 92729 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 565 8 1 4 6.1 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
72714079 92730 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 565 8 1 4 6.1 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
CHEMBL2435886 92730 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 565 8 1 4 6.1 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
49871007 58830 None 15 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at CCR5 assessed as inhibition of receptor internalizationAntagonist activity at CCR5 assessed as inhibition of receptor internalization
ChEMBL 559 5 0 6 4.8 CCO[C@@H]1Cc2cc(C(F)(F)F)ccc2[C@H]1N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C 10.1021/ml1001536
CHEMBL1688243 58830 None 15 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at CCR5 assessed as inhibition of receptor internalizationAntagonist activity at CCR5 assessed as inhibition of receptor internalization
ChEMBL 559 5 0 6 4.8 CCO[C@@H]1Cc2cc(C(F)(F)F)ccc2[C@H]1N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C 10.1021/ml1001536
44194588 10891 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 622 11 2 6 3.2 C=CCN(C(=O)Cc1ccc(S(=O)(=O)NC)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172625 10891 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 622 11 2 6 3.2 C=CCN(C(=O)Cc1ccc(S(=O)(=O)NC)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
57394057 69243 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 519 10 1 6 4.9 COc1ccc(N(Cc2cccnc2)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(F)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
CHEMBL1926897 69243 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 519 10 1 6 4.9 COc1ccc(N(Cc2cccnc2)C2CCN([C@H](C)CCNC(=O)c3c(C)cc(F)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
49798089 10831 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 580 9 2 4 4.7 C=CCN(C(=O)NCc1ccc(F)cc1F)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172050 10831 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 580 9 2 4 4.7 C=CCN(C(=O)NCc1ccc(F)cc1F)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
49798090 10832 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 580 9 2 4 4.7 C=CCN(C(=O)NCc1ccc(F)c(F)c1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172051 10832 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 580 9 2 4 4.7 C=CCN(C(=O)NCc1ccc(F)c(F)c1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
50915506 19052 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 848 11 2 6 8.2 CC(C)(C)NS(=O)(=O)c1cc(C(=O)N2CCC(CCN3CCC(N(C(=O)NCc4ccc(C#N)cc4)c4cccc(F)c4)CC3)(c3cccc(F)c3)CC2)c(Cl)cc1F 10.1016/j.bmcl.2010.10.033
CHEMBL1288663 19052 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 848 11 2 6 8.2 CC(C)(C)NS(=O)(=O)c1cc(C(=O)N2CCC(CCN3CCC(N(C(=O)NCc4ccc(C#N)cc4)c4cccc(F)c4)CC3)(c3cccc(F)c3)CC2)c(Cl)cc1F 10.1016/j.bmcl.2010.10.033
49798085 10826 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 562 9 2 4 4.5 C=CCN(C(=O)NCc1ccc(F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172045 10826 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 562 9 2 4 4.5 C=CCN(C(=O)NCc1ccc(F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
72711741 92703 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 579 9 1 4 6.4 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(CC3CCCCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
CHEMBL2435859 92703 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 579 9 1 4 6.4 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(CC3CCCCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
11505350 168890 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 565 8 0 4 6.4 CC(=O)N1CCC(C(=O)N(CCCN2CCC(Sc3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
CHEMBL437494 168890 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 565 8 0 4 6.4 CC(=O)N1CCC(C(=O)N(CCCN2CCC(Sc3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
46225515 202111 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 551 6 0 5 4.1 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL592940 202111 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 551 6 0 5 4.1 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
172447334 195757 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 60 mins by Fluo-4 AM calcium flux based FLIPR assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 60 mins by Fluo-4 AM calcium flux based FLIPR assay
ChEMBL 4060 155 47 57 -9.1 CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)c1ccc(S(=O)(=O)NC2CC3CCC(C2)N3CCCN(C(=O)C2CCN(C(C)=O)CC2)c2ccc(C)c(Cl)c2)cc1)C(N)=O)[C@@H](C)CC 10.1016/j.ejmech.2023.115294
CHEMBL5410204 195757 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 60 mins by Fluo-4 AM calcium flux based FLIPR assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 60 mins by Fluo-4 AM calcium flux based FLIPR assay
ChEMBL 4060 155 47 57 -9.1 CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)c1ccc(S(=O)(=O)NC2CC3CCC(C2)N3CCCN(C(=O)C2CCN(C(C)=O)CC2)c2ccc(C)c(Cl)c2)cc1)C(N)=O)[C@@H](C)CC 10.1016/j.ejmech.2023.115294
3008904 202422 None 0 Human Functional pIC50 = 8.0 8.0 1 2
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 537 6 0 5 5.0 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3cccc(C#N)c3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL59511 202422 None 0 Human Functional pIC50 = 8.0 8.0 1 2
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 537 6 0 5 5.0 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3cccc(C#N)c3)c3ccccc3)CC2)CC1 10.1021/jm031046g
118727180 117448 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 592 8 0 5 4.2 CC(=O)N1CCC(C(=O)N(CCCN2CCN(S(=O)(=O)c3ccc(F)cc3)CC2C)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
CHEMBL3397991 117448 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 592 8 0 5 4.2 CC(=O)N1CCC(C(=O)N(CCCN2CCN(S(=O)(=O)c3ccc(F)cc3)CC2C)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
44511967 69234 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 516 10 1 7 4.5 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)ncnc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
CHEMBL1926888 69234 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 516 10 1 7 4.5 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)ncnc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
44511967 69234 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 516 10 1 7 4.5 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)ncnc3C)CC2)cc1 10.1021/ml2002604
CHEMBL1926888 69234 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 516 10 1 7 4.5 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)ncnc3C)CC2)cc1 10.1021/ml2002604
3008907 205124 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 405 4 1 3 4.9 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL61465 205124 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 405 4 1 3 4.9 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccccc3)CC2)CC1 10.1021/jm031046g
505868 27787 None 0 Human Functional pIC50 = 7 7.0 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 488 8 0 4 5.6 CCCN(c1ccccn1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00988-5
CHEMBL137072 27787 None 0 Human Functional pIC50 = 7 7.0 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 488 8 0 4 5.6 CCCN(c1ccccn1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00988-5
44357072 98545 None 0 Human Functional pIC50 = 7 7.0 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 553 12 1 7 4.7 CCCN(c1nccc(OC)n1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/s0960-894x(02)00988-5
CHEMBL275998 98545 None 0 Human Functional pIC50 = 7 7.0 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 553 12 1 7 4.7 CCCN(c1nccc(OC)n1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/s0960-894x(02)00988-5
505878 119252 None 0 Human Functional pIC50 = 7 7.0 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 518 10 1 5 5.5 CCCN(c1ccccn1)C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00988-5
CHEMBL343160 119252 None 0 Human Functional pIC50 = 7 7.0 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 518 10 1 5 5.5 CCCN(c1ccccn1)C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00988-5
44356944 119283 None 1 Human Functional pIC50 = 7 7.0 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 509 10 1 6 4.3 CCN(c1ncccn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/s0960-894x(02)00988-5
CHEMBL343366 119283 None 1 Human Functional pIC50 = 7 7.0 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 509 10 1 6 4.3 CCN(c1ncccn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/s0960-894x(02)00988-5
44357078 119465 None 0 Human Functional pIC50 = 7 7.0 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 591 11 1 6 5.7 CCCN(c1ncc(C(F)(F)F)cn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/s0960-894x(02)00988-5
CHEMBL344641 119465 None 0 Human Functional pIC50 = 7 7.0 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 591 11 1 6 5.7 CCCN(c1ncc(C(F)(F)F)cn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/s0960-894x(02)00988-5
46225346 202498 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 551 7 1 6 3.2 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)(C)CO)CC3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL595570 202498 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 551 7 1 6 3.2 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)(C)CO)CC3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
46837554 10671 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated GTPgammaS binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated GTPgammaS binding by scintillation proximity assay
ChEMBL 516 9 1 4 5.6 COC(=O)C1(Cc2ccccc2)CCN(CC[C@H](NC(=O)C2CCC2)c2ccc(C(F)(F)F)cc2)CC1 10.1016/j.ejmech.2010.03.003
CHEMBL1170529 10671 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated GTPgammaS binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated GTPgammaS binding by scintillation proximity assay
ChEMBL 516 9 1 4 5.6 COC(=O)C1(Cc2ccccc2)CCN(CC[C@H](NC(=O)C2CCC2)c2ccc(C(F)(F)F)cc2)CC1 10.1016/j.ejmech.2010.03.003
46837425 103461 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated GTPgammaS binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated GTPgammaS binding by scintillation proximity assay
ChEMBL 547 7 1 5 6.8 Cc1nc2cccnc2n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)c1ccc(F)cc1)c1cccc2ccccc12 10.1016/j.ejmech.2010.03.003
CHEMBL3084746 103461 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated GTPgammaS binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated GTPgammaS binding by scintillation proximity assay
ChEMBL 547 7 1 5 6.8 Cc1nc2cccnc2n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)c1ccc(F)cc1)c1cccc2ccccc12 10.1016/j.ejmech.2010.03.003
53389085 66487 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 438 16 0 0 9.5 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.bmcl.2012.05.127
CHEMBL1817911 66487 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 438 16 0 0 9.5 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.bmcl.2012.05.127
CHEMBL1852138 66487 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 438 16 0 0 9.5 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.bmcl.2012.05.127
CHEMBL2057814 66487 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 438 16 0 0 9.5 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.bmcl.2012.05.127
53389085 66487 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 438 16 0 0 9.5 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.ejmech.2012.07.049
CHEMBL1817911 66487 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 438 16 0 0 9.5 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.ejmech.2012.07.049
CHEMBL1852138 66487 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 438 16 0 0 9.5 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.ejmech.2012.07.049
CHEMBL2057814 66487 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 438 16 0 0 9.5 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.ejmech.2012.07.049
46226118 14127 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 531 10 1 4 6.0 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccccc3)c1)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL1198032 14127 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 531 10 1 4 6.0 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccccc3)c1)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL593605 14127 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 531 10 1 4 6.0 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccccc3)c1)CC2 10.1016/j.bmcl.2009.11.018
44395365 124540 None 0 Human Functional pIC50 = 5 5.0 - 1
Inhibition of MIP-1alpha ligand of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assayInhibition of MIP-1alpha ligand of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assay
ChEMBL 386 7 2 7 1.8 CC(OC(=O)/C=C/c1ccc(O)cc1)C(=O)[C@H]1C[C@@H]1[C@H](O)[C@H]1CC=CC(=O)O1 10.1016/j.bmcl.2004.08.021
CHEMBL363999 124540 None 0 Human Functional pIC50 = 5 5.0 - 1
Inhibition of MIP-1alpha ligand of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assayInhibition of MIP-1alpha ligand of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assay
ChEMBL 386 7 2 7 1.8 CC(OC(=O)/C=C/c1ccc(O)cc1)C(=O)[C@H]1C[C@@H]1[C@H](O)[C@H]1CC=CC(=O)O1 10.1016/j.bmcl.2004.08.021
53389085 66487 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 438 16 0 0 9.5 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.bmcl.2011.07.058
CHEMBL1817911 66487 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 438 16 0 0 9.5 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.bmcl.2011.07.058
CHEMBL1852138 66487 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 438 16 0 0 9.5 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.bmcl.2011.07.058
CHEMBL2057814 66487 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 438 16 0 0 9.5 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.bmcl.2011.07.058
54752873 77204 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2012.05.127
CHEMBL2057812 77204 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2012.05.127
CHEMBL2078840 77204 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2012.05.127
54752873 77204 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.ejmech.2012.07.049
CHEMBL2057812 77204 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.ejmech.2012.07.049
CHEMBL2078840 77204 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.ejmech.2012.07.049
46225343 202597 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 521 6 0 5 3.8 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)C)CC3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL596299 202597 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 521 6 0 5 3.8 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)C)CC3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
3008911 101035 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 458 4 1 4 5.4 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3cccc4ccn(C)c34)CC2)CC1 10.1021/jm031046g
CHEMBL294271 101035 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 458 4 1 4 5.4 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3cccc4ccn(C)c34)CC2)CC1 10.1021/jm031046g
3008925 100968 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 492 5 1 3 6.5 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2cccc3[nH]ccc23)CC1 10.1021/jm031046g
CHEMBL293900 100968 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 492 5 1 3 6.5 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2cccc3[nH]ccc23)CC1 10.1021/jm031046g
90656325 111129 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 431 7 1 6 3.8 CC(C)Oc1ccc(N2CCN(Cc3ccccc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.bmcl.2014.03.073
CHEMBL3263023 111129 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 431 7 1 6 3.8 CC(C)Oc1ccc(N2CCN(Cc3ccccc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.bmcl.2014.03.073
70690766 77199 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 288 9 0 0 5.2 CCCCCCCCCCc1c(C)cc(C)[n+]2c1CCC2 10.1016/j.ejmech.2012.07.049
CHEMBL2064266 77199 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 288 9 0 0 5.2 CCCCCCCCCCc1c(C)cc(C)[n+]2c1CCC2 10.1016/j.ejmech.2012.07.049
CHEMBL2078746 77199 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 288 9 0 0 5.2 CCCCCCCCCCc1c(C)cc(C)[n+]2c1CCC2 10.1016/j.ejmech.2012.07.049
57397596 69226 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 646 12 2 6 7.6 CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2ccccc2)c2ccc(Oc3ccc(C(=O)O)cc3)cc2)CC1 10.1016/j.bmcl.2011.09.133
CHEMBL1926878 69226 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 646 12 2 6 7.6 CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2ccccc2)c2ccc(Oc3ccc(C(=O)O)cc3)cc2)CC1 10.1016/j.bmcl.2011.09.133
49798132 10735 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 547 9 1 4 4.4 C=CCN(C(=O)Cc1ccc(F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1171029 10735 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 547 9 1 4 4.4 C=CCN(C(=O)Cc1ccc(F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
52948296 19083 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 810 13 2 6 7.6 CCCCN(C(=O)NCc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288924 19083 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 810 13 2 6 7.6 CCCCN(C(=O)NCc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
44357379 28146 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 535 11 1 6 4.7 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(N(CC3CC3)c3ncccn3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00988-5
CHEMBL137327 28146 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 535 11 1 6 4.7 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(N(CC3CC3)c3ncccn3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00988-5
505869 28274 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 486 8 0 4 5.4 C=CCN(c1ccccn1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00988-5
CHEMBL137419 28274 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 486 8 0 4 5.4 C=CCN(c1ccccn1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00988-5
44357375 116067 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 523 11 1 6 4.7 CCCN(c1cncnc1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/s0960-894x(02)00988-5
CHEMBL335562 116067 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 523 11 1 6 4.7 CCCN(c1cncnc1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/s0960-894x(02)00988-5
9914742 166730 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 523 11 1 6 4.7 CCCN(c1ncccn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/s0960-894x(02)00988-5
CHEMBL428104 166730 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 523 11 1 6 4.7 CCCN(c1ncccn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/s0960-894x(02)00988-5
3008927 201314 None 0 Human Functional pIC50 = 8.0 8.0 -2 2
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 482 5 0 4 6.0 Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL58387 201314 None 0 Human Functional pIC50 = 8.0 8.0 -2 2
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 482 5 0 4 6.0 Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
53325460 58511 None 0 Human Functional pIC50 = 8.0 8.0 -2 2
Antagonist activity at human CCR5 receptor by chemotaxis assayAntagonist activity at human CCR5 receptor by chemotaxis assay
ChEMBL 538 6 1 6 3.6 CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@](CC(F)(F)F)(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)C1 10.1016/j.bmcl.2011.01.015
CHEMBL1683190 58511 None 0 Human Functional pIC50 = 8.0 8.0 -2 2
Antagonist activity at human CCR5 receptor by chemotaxis assayAntagonist activity at human CCR5 receptor by chemotaxis assay
ChEMBL 538 6 1 6 3.6 CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@](CC(F)(F)F)(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)C1 10.1016/j.bmcl.2011.01.015
3008934 201149 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 467 5 0 3 6.2 Cc1cccc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL58101 201149 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 467 5 0 3 6.2 Cc1cccc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
49864972 15791 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 640 11 2 6 3.3 C=CCN(C(=O)Cc1ccc(S(=O)(=O)NC)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccc(F)cc2)CC1 10.1016/j.bmcl.2010.05.046
CHEMBL1222770 15791 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 640 11 2 6 3.3 C=CCN(C(=O)Cc1ccc(S(=O)(=O)NC)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccc(F)cc2)CC1 10.1016/j.bmcl.2010.05.046
49864975 15794 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 695 11 2 6 4.3 C=CCN(C(=O)NCc1ccc(S(=O)(=O)N(C)C)cc1)[C@@H]1C[C@@H]2CC[C@H](C1)N2C[C@H]1CN(C(=O)C2CCCC2)C[C@]1(O)c1cccc(F)c1 10.1016/j.bmcl.2010.05.046
CHEMBL1222773 15794 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 695 11 2 6 4.3 C=CCN(C(=O)NCc1ccc(S(=O)(=O)N(C)C)cc1)[C@@H]1C[C@@H]2CC[C@H](C1)N2C[C@H]1CN(C(=O)C2CCCC2)C[C@]1(O)c1cccc(F)c1 10.1016/j.bmcl.2010.05.046
52943424 19072 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 833 12 2 7 6.8 C=CCN(C(=O)Nc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288913 19072 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 833 12 2 7 6.8 C=CCN(C(=O)Nc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
73346388 92722 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 566 8 1 4 6.6 CNC(=O)c1ccc(Oc2ccc(CN3CCC(N4C(=O)N(C5CCCCC5)C[C@H]4c4ccccc4)CC3)cc2)cc1 10.1021/jm401101p
CHEMBL2435878 92722 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 566 8 1 4 6.6 CNC(=O)c1ccc(Oc2ccc(CN3CCC(N4C(=O)N(C5CCCCC5)C[C@H]4c4ccccc4)CC3)cc2)cc1 10.1021/jm401101p
118727176 117444 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 542 8 0 4 5.0 CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3cccc(F)c3)CC2C)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
CHEMBL3397987 117444 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 542 8 0 4 5.0 CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3cccc(F)c3)CC2C)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
168279183 191020 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 541 9 1 8 5.2 COC(=O)C1CCC(C(=O)N[C@@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)c2cccs2)CC1 10.1021/acs.jmedchem.2c01383
CHEMBL5185201 191020 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 541 9 1 8 5.2 COC(=O)C1CCC(C(=O)N[C@@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)c2cccs2)CC1 10.1021/acs.jmedchem.2c01383
145967391 164344 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Antagonist activity at CCR5 (unknown origin)Antagonist activity at CCR5 (unknown origin)
ChEMBL 589 7 0 5 6.9 Cc1nc2cnccc2n1C1CCN(CCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)Cc3ccccc3)C2)CC1 10.1021/acs.jmedchem.8b00180
CHEMBL4211358 164344 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Antagonist activity at CCR5 (unknown origin)Antagonist activity at CCR5 (unknown origin)
ChEMBL 589 7 0 5 6.9 Cc1nc2cnccc2n1C1CCN(CCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)Cc3ccccc3)C2)CC1 10.1021/acs.jmedchem.8b00180
76327885 103458 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at CCR5 receptor expressed in CHO cells assessed as inhibition of RANTES-induced [32S]GTPgammaS bindingAntagonist activity at CCR5 receptor expressed in CHO cells assessed as inhibition of RANTES-induced [32S]GTPgammaS binding
ChEMBL 418 6 0 6 4.3 COC(=O)[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3cccnc31)C2)c1ccccc1 10.1016/j.bmcl.2010.02.023
CHEMBL3084729 103458 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at CCR5 receptor expressed in CHO cells assessed as inhibition of RANTES-induced [32S]GTPgammaS bindingAntagonist activity at CCR5 receptor expressed in CHO cells assessed as inhibition of RANTES-induced [32S]GTPgammaS binding
ChEMBL 418 6 0 6 4.3 COC(=O)[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3cccnc31)C2)c1ccccc1 10.1016/j.bmcl.2010.02.023
44194496 10822 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 587 9 1 8 4.3 C=CCN(C(=O)OCc1ccc2nonc2c1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172041 10822 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 587 9 1 8 4.3 C=CCN(C(=O)OCc1ccc2nonc2c1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
57397595 69225 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 581 10 1 5 5.8 CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2ccccc2)c2ccc(C(=O)N(C)C)cc2)CC1 10.1016/j.bmcl.2011.09.133
CHEMBL1926877 69225 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 581 10 1 5 5.8 CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2ccccc2)c2ccc(C(=O)N(C)C)cc2)CC1 10.1016/j.bmcl.2011.09.133
46225348 202628 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 515 6 0 5 3.8 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C4CCCC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL596519 202628 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 515 6 0 5 3.8 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C4CCCC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
3008936 201152 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 484 5 0 4 4.8 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL58109 201152 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 484 5 0 4 4.8 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
57401042 69233 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 560 9 1 6 5.8 CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2cccc(C#N)c2)c2ccc(C#N)cc2)CC1 10.1016/j.bmcl.2011.09.133
CHEMBL1926887 69233 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 560 9 1 6 5.8 CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2cccc(C#N)c2)c2ccc(C#N)cc2)CC1 10.1016/j.bmcl.2011.09.133
126567277 165736 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 553 8 1 6 6.7 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(Cl)s1 10.1021/acs.jmedchem.8b01077
CHEMBL4243842 165736 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 553 8 1 6 6.7 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(Cl)s1 10.1021/acs.jmedchem.8b01077
3008930 201136 None 0 Human Functional pIC50 = 7.9 7.9 1 2
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 499 5 0 5 4.6 Cc1nc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL58004 201136 None 0 Human Functional pIC50 = 7.9 7.9 1 2
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 499 5 0 5 4.6 Cc1nc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
11527582 76455 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 664 10 1 5 5.9 CC(C)(C)NC(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(S(C)(=O)=O)CC3)c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1021/jm051034q
CHEMBL205964 76455 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 664 10 1 5 5.9 CC(C)(C)NC(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(S(C)(=O)=O)CC3)c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1021/jm051034q
505875 25983 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 487 8 0 5 4.8 C=CCN(c1ncccn1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00988-5
CHEMBL135432 25983 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 487 8 0 5 4.8 C=CCN(c1ncccn1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00988-5
505873 27954 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 486 8 0 4 5.4 C=CCN(c1cccnc1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00988-5
CHEMBL137206 27954 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 486 8 0 4 5.4 C=CCN(c1cccnc1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00988-5
3008913 102031 None 0 Human Functional pIC50 = 7.9 7.9 -1 2
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 495 6 0 3 6.5 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL301454 102031 None 0 Human Functional pIC50 = 7.9 7.9 -1 2
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 495 6 0 3 6.5 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
57395816 69238 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 535 10 1 6 5.4 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3cnc(Cl)cc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
CHEMBL1926892 69238 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 535 10 1 6 5.4 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3cnc(Cl)cc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
72712159 92711 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 493 6 0 2 7.1 O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(-c3ccccc3)cc2)CC1 10.1021/jm401101p
CHEMBL2435867 92711 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 493 6 0 2 7.1 O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(-c3ccccc3)cc2)CC1 10.1021/jm401101p
73352463 92690 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 553 8 1 4 7.0 O=C(O)c1cccc(Oc2ccc(CN3CCC(N4C(=O)N(C5CCCCC5)C[C@H]4c4ccccc4)CC3)cc2)c1 10.1021/jm401101p
CHEMBL2435846 92690 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 553 8 1 4 7.0 O=C(O)c1cccc(Oc2ccc(CN3CCC(N4C(=O)N(C5CCCCC5)C[C@H]4c4ccccc4)CC3)cc2)c1 10.1021/jm401101p
491775 12882 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1021/jm060051s
CHEMBL1188807 12882 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1021/jm060051s
CHEMBL537424 12882 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1021/jm060051s
10117348 13932 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 455 8 1 4 4.1 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(OC)cc1)CC2 10.1021/jm060051s
CHEMBL1196455 13932 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 455 8 1 4 4.1 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(OC)cc1)CC2 10.1021/jm060051s
CHEMBL557015 13932 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 455 8 1 4 4.1 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(OC)cc1)CC2 10.1021/jm060051s
10117348 13932 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 455 8 1 4 4.1 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(OC)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1196455 13932 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 455 8 1 4 4.1 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(OC)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL557015 13932 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 455 8 1 4 4.1 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(OC)cc1)CC2 10.1016/j.bmc.2010.05.057
10117348 13932 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 455 8 1 4 4.1 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(OC)cc1)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL1196455 13932 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 455 8 1 4 4.1 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(OC)cc1)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL557015 13932 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 455 8 1 4 4.1 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(OC)cc1)CC2 10.1016/j.bmcl.2009.11.018
16728326 10819 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 589 9 1 7 4.5 C=CCN(C(=O)OCc1ccc2c(c1)OCO2)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172037 10819 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 589 9 1 7 4.5 C=CCN(C(=O)OCc1ccc2c(c1)OCO2)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
76317388 104648 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 614 11 0 4 5.8 CCN(CCc1ccc(Cl)cc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
CHEMBL3104693 104648 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 614 11 0 4 5.8 CCN(CCc1ccc(Cl)cc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
CHEMBL5071060 216739 None 0 Human Functional pIC50 = 6.9 6.9 -3 2
Antagonist activity at CCR5 (unknown origin) expressed in HOS cells co-expressing Gqi-5 assessed as inhibition CCL5-stimulated Ca2+ mobilization by calcium mobilization assayAntagonist activity at CCR5 (unknown origin) expressed in HOS cells co-expressing Gqi-5 assessed as inhibition CCL5-stimulated Ca2+ mobilization by calcium mobilization assay
ChEMBL None None None Cc1nnc(C(C)C)n1C1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)cc1 10.1021/acs.jmedchem.1c00408
89702731 109452 None 0 Human Functional pIC50 = 6.9 6.9 -3 2
Antagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challengeAntagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challenge
ChEMBL 1197 28 7 15 6.6 Cc1nnc(C(C)C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)cc1 10.1039/c3md00080j
CHEMBL3219777 109452 None 0 Human Functional pIC50 = 6.9 6.9 -3 2
Antagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challengeAntagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challenge
ChEMBL 1197 28 7 15 6.6 Cc1nnc(C(C)C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)cc1 10.1039/c3md00080j
162650661 180255 None 0 Human Functional pIC50 = 6.9 6.9 -3 2
Antagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysisAntagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysis
ChEMBL 1197 28 7 15 6.6 Cc1nnc(C(C)C)n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)cc1 10.1016/j.bmc.2016.09.059
CHEMBL4748891 180255 None 0 Human Functional pIC50 = 6.9 6.9 -3 2
Antagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysisAntagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysis
ChEMBL 1197 28 7 15 6.6 Cc1nnc(C(C)C)n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)cc1 10.1016/j.bmc.2016.09.059
89702731 109452 None 0 Human Functional pIC50 = 6.9 6.9 -3 2
Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.
ChEMBL 1197 28 7 15 6.6 Cc1nnc(C(C)C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)cc1 nan
CHEMBL3219777 109452 None 0 Human Functional pIC50 = 6.9 6.9 -3 2
Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.
ChEMBL 1197 28 7 15 6.6 Cc1nnc(C(C)C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)cc1 nan
CHEMBL5074037 216797 None 0 Human Functional pIC50 = 5.9 5.9 -1 2
Antagonist activity at CCR5 (unknown origin) expressed in HOS cells co-expressing Gqi-5 assessed as inhibition CCL5-stimulated Ca2+ mobilization by calcium mobilization assayAntagonist activity at CCR5 (unknown origin) expressed in HOS cells co-expressing Gqi-5 assessed as inhibition CCL5-stimulated Ca2+ mobilization by calcium mobilization assay
ChEMBL None None None CC(C)c1nnc(CCNC(=O)COCC(=O)NCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)n1C1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1 10.1021/acs.jmedchem.1c00408
3008936 201152 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 484 5 0 4 4.8 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL58109 201152 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 484 5 0 4 4.8 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
122185609 122974 None 0 Human Functional pIC50 = 4.9 4.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 514 6 2 2 5.7 Cc1c(CNC(=O)c2ccc3ccccc3c2)c(C)[n+]2c(c1CNC(=O)c1ccc3ccccc3c1)CCC2 10.1016/j.bmcl.2015.06.029
CHEMBL3604296 122974 None 0 Human Functional pIC50 = 4.9 4.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 514 6 2 2 5.7 Cc1c(CNC(=O)c2ccc3ccccc3c2)c(C)[n+]2c(c1CNC(=O)c1ccc3ccccc3c1)CCC2 10.1016/j.bmcl.2015.06.029
CHEMBL3606029 122974 None 0 Human Functional pIC50 = 4.9 4.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 514 6 2 2 5.7 Cc1c(CNC(=O)c2ccc3ccccc3c2)c(C)[n+]2c(c1CNC(=O)c1ccc3ccccc3c1)CCC2 10.1016/j.bmcl.2015.06.029
162677279 183584 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysisAntagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysis
ChEMBL 886 25 5 11 4.9 CNC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)Nc1cccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)c1 10.1016/j.bmc.2016.09.059
CHEMBL4799343 183584 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysisAntagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysis
ChEMBL 886 25 5 11 4.9 CNC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)Nc1cccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)c1 10.1016/j.bmc.2016.09.059
46225344 202525 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 535 5 0 5 4.2 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)(C)C)CC3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL595760 202525 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 535 5 0 5 4.2 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)(C)C)CC3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
122185613 122982 None 0 Human Functional pIC50 = 4.9 4.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 578 8 2 2 7.5 Cc1c(CNC(=O)c2ccc(C3CCCCC3)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(C3CCCCC3)cc1)CCC2 10.1016/j.bmcl.2015.06.029
CHEMBL3604298 122982 None 0 Human Functional pIC50 = 4.9 4.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 578 8 2 2 7.5 Cc1c(CNC(=O)c2ccc(C3CCCCC3)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(C3CCCCC3)cc1)CCC2 10.1016/j.bmcl.2015.06.029
CHEMBL3606076 122982 None 0 Human Functional pIC50 = 4.9 4.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 578 8 2 2 7.5 Cc1c(CNC(=O)c2ccc(C3CCCCC3)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(C3CCCCC3)cc1)CCC2 10.1016/j.bmcl.2015.06.029
21064283 14337 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 561 10 2 5 5.6 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL1170878 14337 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 561 10 2 5 5.6 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL1200019 14337 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 561 10 2 5 5.6 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
21064283 14337 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 561 10 2 5 5.6 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1170878 14337 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 561 10 2 5 5.6 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1200019 14337 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 561 10 2 5 5.6 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2010.05.057
46226132 14124 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 575 11 2 5 5.7 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(C(=O)O)cc3)c1)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL1198014 14124 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 575 11 2 5 5.7 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(C(=O)O)cc3)c1)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL593205 14124 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 575 11 2 5 5.7 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(C(=O)O)cc3)c1)CC2 10.1016/j.bmcl.2009.11.018
3002977 2460 None 43 Human Functional pIC50 = 7.9 7.9 2 4
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmc.2014.12.052
3002977.0 2460 None 43 Human Functional pIC50 = 7.9 7.9 2 4
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmc.2014.12.052
803 2460 None 43 Human Functional pIC50 = 7.9 7.9 2 4
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmc.2014.12.052
806 2460 None 43 Human Functional pIC50 = 7.9 7.9 2 4
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmc.2014.12.052
CHEMBL1201187 2460 None 43 Human Functional pIC50 = 7.9 7.9 2 4
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmc.2014.12.052
CHEMBL256907 2460 None 43 Human Functional pIC50 = 7.9 7.9 2 4
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmc.2014.12.052
CHEMBL584744 2460 None 43 Human Functional pIC50 = 7.9 7.9 2 4
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmc.2014.12.052
DB04835 2460 None 43 Human Functional pIC50 = 7.9 7.9 2 4
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmc.2014.12.052
3008930 201136 None 0 Human Functional pIC50 = 7.9 7.9 1 2
Migration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells oractivated human peripheral blood lymphocytesMigration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells oractivated human peripheral blood lymphocytes
ChEMBL 499 5 0 5 4.6 Cc1nc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL58004 201136 None 0 Human Functional pIC50 = 7.9 7.9 1 2
Migration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells oractivated human peripheral blood lymphocytesMigration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells oractivated human peripheral blood lymphocytes
ChEMBL 499 5 0 5 4.6 Cc1nc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
72713860 92757 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 532 8 1 5 4.9 Cc1ncnc(C)c1C(=O)NCC[C@@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
CHEMBL2435913 92757 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 532 8 1 5 4.9 Cc1ncnc(C)c1C(=O)NCC[C@@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
57395818 69249 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 548 10 1 7 4.2 Cc1ccncc1CN(c1ccc([S+](C)[O-])cc1)C1CCN([C@H](C)CCNC(=O)c2c(C)ncnc2C)CC1 10.1016/j.bmcl.2011.09.133
CHEMBL1926903 69249 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 548 10 1 7 4.2 Cc1ccncc1CN(c1ccc([S+](C)[O-])cc1)C1CCN([C@H](C)CCNC(=O)c2c(C)ncnc2C)CC1 10.1016/j.bmcl.2011.09.133
16728785 12834 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)[C@@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
CHEMBL1188408 12834 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)[C@@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
CHEMBL536298 12834 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)[C@@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
16728785 12834 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)[C@@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1188408 12834 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)[C@@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL536298 12834 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)[C@@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
21064293 14333 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 547 10 1 5 5.9 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(OC)cc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1170874 14333 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 547 10 1 5 5.9 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(OC)cc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1200015 14333 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 547 10 1 5 5.9 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(OC)cc3)cc1)CC2 10.1016/j.bmc.2010.05.057
46226126 14121 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 561 11 1 5 6.0 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(OC)cc3)c1)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL1198011 14121 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 561 11 1 5 6.0 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(OC)cc3)c1)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL593177 14121 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 561 11 1 5 6.0 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(OC)cc3)c1)CC2 10.1016/j.bmcl.2009.11.018
23577409 66439 None 0 Human Functional pIC50 = 4.9 4.9 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 563 10 3 6 4.2 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813439 66439 None 0 Human Functional pIC50 = 4.9 4.9 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 563 10 3 6 4.2 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851891 66439 None 0 Human Functional pIC50 = 4.9 4.9 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 563 10 3 6 4.2 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
162660215 181318 None 0 Human Functional pIC50 = 5.9 5.9 -79 2
Antagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysisAntagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysis
ChEMBL 1197 28 7 15 6.6 Cc1nnc(C(C)C)n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cccc(NC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)c1 10.1016/j.bmc.2016.09.059
CHEMBL4761273 181318 None 0 Human Functional pIC50 = 5.9 5.9 -79 2
Antagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysisAntagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysis
ChEMBL 1197 28 7 15 6.6 Cc1nnc(C(C)C)n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cccc(NC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)c1 10.1016/j.bmc.2016.09.059
122185641 122988 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 414 6 2 2 3.4 Cc1c(CNC(=O)c2ccccc2)c(C)[n+]2c(c1CNC(=O)c1ccccc1)CCC2 10.1016/j.bmcl.2015.06.029
CHEMBL3604312 122988 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 414 6 2 2 3.4 Cc1c(CNC(=O)c2ccccc2)c(C)[n+]2c(c1CNC(=O)c1ccccc1)CCC2 10.1016/j.bmcl.2015.06.029
CHEMBL3606113 122988 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 414 6 2 2 3.4 Cc1c(CNC(=O)c2ccccc2)c(C)[n+]2c(c1CNC(=O)c1ccccc1)CCC2 10.1016/j.bmcl.2015.06.029
46225350 203615 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 515 7 0 5 3.8 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)CC4CCCC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL603325 203615 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 515 7 0 5 3.8 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)CC4CCCC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
70694942 77229 None 0 Human Functional pIC50 = 4.9 4.9 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 286 8 0 0 5.3 CCCCCCCC/C=C/c1c(C)cc2[n+](c1C)CCC2 10.1016/j.ejmech.2012.07.049
CHEMBL2064263 77229 None 0 Human Functional pIC50 = 4.9 4.9 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 286 8 0 0 5.3 CCCCCCCC/C=C/c1c(C)cc2[n+](c1C)CCC2 10.1016/j.ejmech.2012.07.049
CHEMBL2079186 77229 None 0 Human Functional pIC50 = 4.9 4.9 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 286 8 0 0 5.3 CCCCCCCC/C=C/c1c(C)cc2[n+](c1C)CCC2 10.1016/j.ejmech.2012.07.049
168283795 191002 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 586 10 2 9 4.2 COc1ccc(S(N)(=O)=O)cc1C(=O)N[C@@H](CCN1[C@@H]2CC[C@H]1C[C@H](n1c(C)nnc1C(C)C)C2)c1cccs1 10.1021/acs.jmedchem.2c01383
CHEMBL5184978 191002 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 586 10 2 9 4.2 COc1ccc(S(N)(=O)=O)cc1C(=O)N[C@@H](CCN1[C@@H]2CC[C@H]1C[C@H](n1c(C)nnc1C(C)C)C2)c1cccs1 10.1021/acs.jmedchem.2c01383
90666578 109455 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challengeAntagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challenge
ChEMBL 528 8 2 6 5.5 Cc1nnc(C(C)C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(N)cc1 10.1039/c3md00080j
CHEMBL3219780 109455 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challengeAntagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challenge
ChEMBL 528 8 2 6 5.5 Cc1nnc(C(C)C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(N)cc1 10.1039/c3md00080j
112500049 132553 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.
ChEMBL 642 11 2 7 6.7 Cc1nnc(C(C)C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COC(C)(C)C)cc1 nan
CHEMBL3697626 132553 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.
ChEMBL 642 11 2 7 6.7 Cc1nnc(C(C)C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COC(C)(C)C)cc1 nan
71458737 81813 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 563 9 2 6 5.2 Cc1ccncc1CN(C(=O)Nc1cccnc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 10.1021/ml2002604
CHEMBL2164216 81813 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 563 9 2 6 5.2 Cc1ccncc1CN(C(=O)Nc1cccnc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 10.1021/ml2002604
49864974 15797 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 656 9 2 4 6.1 C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)[C@H]1C[C@@H]2CC[C@H](C1)N2C[C@H]1CN(C(=O)C2CCCC2)C[C@]1(O)c1cccc(F)c1 10.1016/j.bmcl.2010.05.046
CHEMBL1222776 15797 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 656 9 2 4 6.1 C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)[C@H]1C[C@@H]2CC[C@H](C1)N2C[C@H]1CN(C(=O)C2CCCC2)C[C@]1(O)c1cccc(F)c1 10.1016/j.bmcl.2010.05.046
76316949 103460 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 receptor expressed in CHO cells assessed as inhibition of RANTES-induced [32S]GTPgammaS bindingAntagonist activity at CCR5 receptor expressed in CHO cells assessed as inhibition of RANTES-induced [32S]GTPgammaS binding
ChEMBL 511 8 1 5 5.5 Cc1nc2cccnc2n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](C(=O)NCc1ccc(F)cc1)c1ccccc1 10.1016/j.bmcl.2010.02.023
CHEMBL3084731 103460 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 receptor expressed in CHO cells assessed as inhibition of RANTES-induced [32S]GTPgammaS bindingAntagonist activity at CCR5 receptor expressed in CHO cells assessed as inhibition of RANTES-induced [32S]GTPgammaS binding
ChEMBL 511 8 1 5 5.5 Cc1nc2cccnc2n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](C(=O)NCc1ccc(F)cc1)c1ccccc1 10.1016/j.bmcl.2010.02.023
3008913 102031 None 0 Human Functional pIC50 = 7.8 7.8 -1 2
Migration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells or activated human peripheral blood lymphocytesMigration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells or activated human peripheral blood lymphocytes
ChEMBL 495 6 0 3 6.5 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL301454 102031 None 0 Human Functional pIC50 = 7.8 7.8 -1 2
Migration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells or activated human peripheral blood lymphocytesMigration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells or activated human peripheral blood lymphocytes
ChEMBL 495 6 0 3 6.5 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
3008917 205241 None 3 Human Functional pIC50 = 7.8 7.8 -6 2
Migration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells oractivated human peripheral blood lymphocytesMigration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells oractivated human peripheral blood lymphocytes
ChEMBL 481 5 0 3 6.6 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL62152 205241 None 3 Human Functional pIC50 = 7.8 7.8 -6 2
Migration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells oractivated human peripheral blood lymphocytesMigration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells oractivated human peripheral blood lymphocytes
ChEMBL 481 5 0 3 6.6 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
49798130 10872 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 559 10 1 5 4.3 C=CCN(C(=O)Cc1ccc(OC)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172438 10872 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 559 10 1 5 4.3 C=CCN(C(=O)Cc1ccc(OC)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
3008902 205137 None 0 Human Functional pIC50 = 7.8 7.8 -1 2
Migration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells or activated human peripheral blood lymphocytesMigration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells or activated human peripheral blood lymphocytes
ChEMBL 512 6 0 4 5.1 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL61536 205137 None 0 Human Functional pIC50 = 7.8 7.8 -1 2
Migration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells or activated human peripheral blood lymphocytesMigration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells or activated human peripheral blood lymphocytes
ChEMBL 512 6 0 4 5.1 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
3008902 205137 None 0 Human Functional pIC50 = 7.8 7.8 -1 2
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 512 6 0 4 5.1 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL61536 205137 None 0 Human Functional pIC50 = 7.8 7.8 -1 2
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 512 6 0 4 5.1 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
3008905 201174 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 537 6 0 5 5.0 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccc(C#N)cc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL58248 201174 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 537 6 0 5 5.0 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccc(C#N)cc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
23577386 66393 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 626 11 3 7 4.3 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(NS(C)(=O)=O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813435 66393 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 626 11 3 7 4.3 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(NS(C)(=O)=O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851672 66393 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 626 11 3 7 4.3 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(NS(C)(=O)=O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
52944616 19073 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 827 13 2 7 6.9 C=CCN(C(=O)NCc1ccc(C(=O)OC)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288914 19073 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 827 13 2 7 6.9 C=CCN(C(=O)NCc1ccc(C(=O)OC)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
72714077 92728 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 532 8 1 5 4.9 Cc1ncnc(C)c1C(=O)NCC[C@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1021/jm401101p
CHEMBL2435884 92728 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 532 8 1 5 4.9 Cc1ncnc(C)c1C(=O)NCC[C@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1021/jm401101p
3008911 101035 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 458 4 1 4 5.4 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3cccc4ccn(C)c34)CC2)CC1 10.1021/jm031046g
CHEMBL294271 101035 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 458 4 1 4 5.4 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3cccc4ccn(C)c34)CC2)CC1 10.1021/jm031046g
49798157 10888 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 597 9 1 4 5.3 C=CCN(C(=O)Cc1ccc(C(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172622 10888 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 597 9 1 4 5.3 C=CCN(C(=O)Cc1ccc(C(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
72711281 92745 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 547 8 1 6 4.6 Cc1cccc(C2CN(C3CCCCC3)C(=O)N2C2CCN(C(C)CCNC(=O)c3c(C)ncnc3C)CC2)n1 10.1021/jm401101p
CHEMBL2435901 92745 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 547 8 1 6 4.6 Cc1cccc(C2CN(C3CCCCC3)C(=O)N2C2CCN(C(C)CCNC(=O)c3c(C)ncnc3C)CC2)n1 10.1021/jm401101p
72711048 92737 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 550 8 1 5 5.0 Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2cccc(F)c2)CC1 10.1021/jm401101p
CHEMBL2435893 92737 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 550 8 1 5 5.0 Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2cccc(F)c2)CC1 10.1021/jm401101p
52944586 19060 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 838 12 1 6 8.6 C=CCN(C(=O)OCc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288873 19060 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 838 12 1 6 8.6 C=CCN(C(=O)OCc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
46225347 202500 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 559 5 0 5 4.7 Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)(C)C)CC3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL595584 202500 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 559 5 0 5 4.7 Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)(C)C)CC3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
46225530 202123 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 550 6 0 4 4.7 Cc1ccnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL592997 202123 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 550 6 0 4 4.7 Cc1ccnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
122668134 190449 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 415 7 1 6 4.2 CC(=O)N[C@@H](CCN1[C@@H]2CC[C@H]1C[C@H](n1c(C)nnc1C(C)C)C2)c1cccs1 10.1021/acs.jmedchem.2c01383
CHEMBL5176665 190449 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 415 7 1 6 4.2 CC(=O)N[C@@H](CCN1[C@@H]2CC[C@H]1C[C@H](n1c(C)nnc1C(C)C)C2)c1cccs1 10.1021/acs.jmedchem.2c01383
118727172 117440 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 524 8 0 4 4.8 CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccccc3)CC2C)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
CHEMBL3397983 117440 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 524 8 0 4 4.8 CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccccc3)CC2C)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
72712373 92717 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 502 6 0 4 5.3 O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(N3CCOCC3)cc2)CC1 10.1021/jm401101p
CHEMBL2435873 92717 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 502 6 0 4 5.3 O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(N3CCOCC3)cc2)CC1 10.1021/jm401101p
3008917 205241 None 3 Human Functional pIC50 = 7.8 7.8 -6 2
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 481 5 0 3 6.6 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL62152 205241 None 3 Human Functional pIC50 = 7.8 7.8 -6 2
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 481 5 0 3 6.6 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
3008935 205186 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 468 5 0 4 5.6 Cc1ccnc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL61828 205186 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 468 5 0 4 5.6 Cc1ccnc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
3008914 203466 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 573 6 0 3 7.2 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccc(Br)cc3)CC2)CC1 10.1021/jm031046g
CHEMBL60225 203466 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 573 6 0 3 7.2 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccc(Br)cc3)CC2)CC1 10.1021/jm031046g
126567253 165607 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 537 8 1 6 6.2 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(F)s1 10.1021/acs.jmedchem.8b01077
CHEMBL4240763 165607 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 537 8 1 6 6.2 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(F)s1 10.1021/acs.jmedchem.8b01077
72712597 92720 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 474 6 1 3 4.8 CNC(=O)c1ccc(CN2CCC(N3C(=O)N(C4CCCCC4)C[C@H]3c3ccccc3)CC2)cc1 10.1021/jm401101p
CHEMBL2435876 92720 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 474 6 1 3 4.8 CNC(=O)c1ccc(CN2CCC(N3C(=O)N(C4CCCCC4)C[C@H]3c3ccccc3)CC2)cc1 10.1021/jm401101p
122668182 190357 None 2 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 573 7 1 6 5.4 CC(=O)N1CCc2c(nc(C)n2[C@@H]2C[C@H]3CC[C@@H](C2)N3CC[C@H](NC(=O)C2CCC(F)(F)CC2)c2ccsc2)C1 10.1021/acs.jmedchem.2c01383
CHEMBL5175220 190357 None 2 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 573 7 1 6 5.4 CC(=O)N1CCc2c(nc(C)n2[C@@H]2C[C@H]3CC[C@@H](C2)N3CC[C@H](NC(=O)C2CCC(F)(F)CC2)c2ccsc2)C1 10.1021/acs.jmedchem.2c01383
52943426 19082 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 751 13 1 6 6.1 C=CCN(C(=O)CCc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288923 19082 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 751 13 1 6 6.1 C=CCN(C(=O)CCc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
16728786 13974 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 493 9 2 5 4.0 CCCCN1C(=O)[C@H]([C@@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
CHEMBL1196759 13974 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 493 9 2 5 4.0 CCCCN1C(=O)[C@H]([C@@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
CHEMBL558043 13974 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 493 9 2 5 4.0 CCCCN1C(=O)[C@H]([C@@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
76310165 104647 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 598 11 0 4 5.3 CCN(CCc1ccc(F)cc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
CHEMBL3104692 104647 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 598 11 0 4 5.3 CCN(CCc1ccc(F)cc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
56673134 66462 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 442 18 0 0 9.3 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.bmcl.2012.05.127
CHEMBL1817913 66462 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 442 18 0 0 9.3 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.bmcl.2012.05.127
CHEMBL1852005 66462 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 442 18 0 0 9.3 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.bmcl.2012.05.127
CHEMBL2057818 66462 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 442 18 0 0 9.3 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.bmcl.2012.05.127
56673134 66462 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 442 18 0 0 9.3 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.bmcl.2011.07.058
CHEMBL1817913 66462 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 442 18 0 0 9.3 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.bmcl.2011.07.058
CHEMBL1852005 66462 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 442 18 0 0 9.3 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.bmcl.2011.07.058
CHEMBL2057818 66462 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 442 18 0 0 9.3 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.bmcl.2011.07.058
72714319 92733 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 566 8 1 5 5.5 Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccccc2Cl)CC1 10.1021/jm401101p
CHEMBL2435889 92733 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 566 8 1 5 5.5 Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccccc2Cl)CC1 10.1021/jm401101p
72711050 92739 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 590 9 1 7 4.7 COC(=O)c1cccc(C2CN(C3CCCCC3)C(=O)N2C2CCN(C(C)CCNC(=O)c3c(C)ncnc3C)CC2)c1 10.1021/jm401101p
CHEMBL2435895 92739 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 590 9 1 7 4.7 COC(=O)c1cccc(C2CN(C3CCCCC3)C(=O)N2C2CCN(C(C)CCNC(=O)c3c(C)ncnc3C)CC2)c1 10.1021/jm401101p
90666579 109456 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challengeAntagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challenge
ChEMBL 628 9 2 7 7.3 Cc1nnc(C(C)C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)OC(C)(C)C)cc1 10.1039/c3md00080j
CHEMBL3219781 109456 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challengeAntagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challenge
ChEMBL 628 9 2 7 7.3 Cc1nnc(C(C)C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)OC(C)(C)C)cc1 10.1039/c3md00080j
57397603 69252 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 604 10 1 7 5.6 Cc1ccncc1CN(c1ccc(N2CCOCC2)cc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 10.1016/j.bmcl.2011.09.133
CHEMBL1927007 69252 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 604 10 1 7 5.6 Cc1ccncc1CN(c1ccc(N2CCOCC2)cc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 10.1016/j.bmcl.2011.09.133
72712375 92719 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 514 6 0 3 6.5 Cc1ccccc1N1CCC(CN2CCC(N3C(=O)N(C4CCCCC4)C[C@H]3c3ccccc3)CC2)CC1 10.1021/jm401101p
CHEMBL2435875 92719 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 514 6 0 3 6.5 Cc1ccccc1N1CCC(CN2CCC(N3C(=O)N(C4CCCCC4)C[C@H]3c3ccccc3)CC2)CC1 10.1021/jm401101p
49871007 58830 None 15 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 assessed as inhibition of intracellular calcium mobilizationAntagonist activity at CCR5 assessed as inhibition of intracellular calcium mobilization
ChEMBL 559 5 0 6 4.8 CCO[C@@H]1Cc2cc(C(F)(F)F)ccc2[C@H]1N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C 10.1021/ml1001536
CHEMBL1688243 58830 None 15 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 assessed as inhibition of intracellular calcium mobilizationAntagonist activity at CCR5 assessed as inhibition of intracellular calcium mobilization
ChEMBL 559 5 0 6 4.8 CCO[C@@H]1Cc2cc(C(F)(F)F)ccc2[C@H]1N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C 10.1021/ml1001536
3008929 198093 None 0 Human Functional pIC50 = 7.8 7.8 -1 2
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 498 5 0 4 5.2 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL556314 198093 None 0 Human Functional pIC50 = 7.8 7.8 -1 2
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 498 5 0 4 5.2 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
145983513 165655 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 457 8 1 6 5.2 Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)C(C)C)s1 10.1021/acs.jmedchem.8b01077
CHEMBL4242034 165655 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 457 8 1 6 5.2 Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)C(C)C)s1 10.1021/acs.jmedchem.8b01077
10278617 95235 None 3 Human Functional pIC50 = 7.8 7.8 1 2
Antagonist activity at human CCR5 expressed in L1.2 cells assessed as MIP-1-alpha-induced Ca2+ mobilizationAntagonist activity at human CCR5 expressed in L1.2 cells assessed as MIP-1-alpha-induced Ca2+ mobilization
ChEMBL 499 5 0 5 4.6 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1 10.1016/j.bmcl.2008.01.108
CHEMBL255858 95235 None 3 Human Functional pIC50 = 7.8 7.8 1 2
Antagonist activity at human CCR5 expressed in L1.2 cells assessed as MIP-1-alpha-induced Ca2+ mobilizationAntagonist activity at human CCR5 expressed in L1.2 cells assessed as MIP-1-alpha-induced Ca2+ mobilization
ChEMBL 499 5 0 5 4.6 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1 10.1016/j.bmcl.2008.01.108
3008931 205104 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Migration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells oractivated human peripheral blood lymphocytesMigration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells oractivated human peripheral blood lymphocytes
ChEMBL 559 6 0 5 7.1 Cc1nc(-c2ccccc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL61374 205104 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Migration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells oractivated human peripheral blood lymphocytesMigration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells oractivated human peripheral blood lymphocytes
ChEMBL 559 6 0 5 7.1 Cc1nc(-c2ccccc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
464990 14390 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 491 8 2 4 4.5 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1c[nH]c(-c3ccccc3)n1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1200254 14390 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 491 8 2 4 4.5 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1c[nH]c(-c3ccccc3)n1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL3216057 14390 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 491 8 2 4 4.5 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1c[nH]c(-c3ccccc3)n1)CC2 10.1016/j.bmc.2010.05.057
46225343 202597 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 521 6 0 5 3.8 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)C)CC3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL596299 202597 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 521 6 0 5 3.8 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)C)CC3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
118727191 117459 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 535 7 0 5 4.7 CC(=O)N1CCC(C(=O)N(CCCN2CCN(c3ccc(C#N)cc3)CC2C)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
CHEMBL3398002 117459 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 535 7 0 5 4.7 CC(=O)N1CCC(C(=O)N(CCCN2CCN(c3ccc(C#N)cc3)CC2C)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
62707284 77218 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 286 8 0 0 5.3 CCCCCCCC/C=C\c1c(C)cc2[n+](c1C)CCC2 10.1016/j.bmcl.2012.05.127
CHEMBL2057807 77218 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 286 8 0 0 5.3 CCCCCCCC/C=C\c1c(C)cc2[n+](c1C)CCC2 10.1016/j.bmcl.2012.05.127
CHEMBL2079027 77218 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 286 8 0 0 5.3 CCCCCCCC/C=C\c1c(C)cc2[n+](c1C)CCC2 10.1016/j.bmcl.2012.05.127
62707284 77218 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 286 8 0 0 5.3 CCCCCCCC/C=C\c1c(C)cc2[n+](c1C)CCC2 10.1016/j.ejmech.2012.07.049
CHEMBL2057807 77218 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 286 8 0 0 5.3 CCCCCCCC/C=C\c1c(C)cc2[n+](c1C)CCC2 10.1016/j.ejmech.2012.07.049
CHEMBL2079027 77218 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 286 8 0 0 5.3 CCCCCCCC/C=C\c1c(C)cc2[n+](c1C)CCC2 10.1016/j.ejmech.2012.07.049
70688700 77225 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 288 9 0 0 5.2 CCCCCCCCCCc1c(C)cc2[n+](c1C)CCC2 10.1016/j.ejmech.2012.07.049
CHEMBL2064264 77225 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 288 9 0 0 5.2 CCCCCCCCCCc1c(C)cc2[n+](c1C)CCC2 10.1016/j.ejmech.2012.07.049
CHEMBL2079127 77225 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 288 9 0 0 5.2 CCCCCCCCCCc1c(C)cc2[n+](c1C)CCC2 10.1016/j.ejmech.2012.07.049
46225346 202498 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 551 7 1 6 3.2 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)(C)CO)CC3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL595570 202498 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 551 7 1 6 3.2 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)(C)CO)CC3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
46225529 202151 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 591 6 0 5 4.3 Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL593195 202151 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 591 6 0 5 4.3 Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
3008912 203529 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 458 4 1 4 5.4 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc4ccn(C)c4c3)CC2)CC1 10.1021/jm031046g
CHEMBL60279 203529 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 458 4 1 4 5.4 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc4ccn(C)c4c3)CC2)CC1 10.1021/jm031046g
90656328 111130 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 476 8 1 8 3.7 CC(C)Oc1ccc(N2CCN(Cc3ccccc3[N+](=O)[O-])CC2)cc1NC(=O)c1cnccn1 10.1016/j.bmcl.2014.03.073
CHEMBL3263025 111130 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 476 8 1 8 3.7 CC(C)Oc1ccc(N2CCN(Cc3ccccc3[N+](=O)[O-])CC2)cc1NC(=O)c1cnccn1 10.1016/j.bmcl.2014.03.073
72712160 92713 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 495 6 0 4 5.9 O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(-c3ncccn3)cc2)CC1 10.1021/jm401101p
CHEMBL2435869 92713 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 495 6 0 4 5.9 O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(-c3ncccn3)cc2)CC1 10.1021/jm401101p
52943389 19063 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 848 13 1 8 7.0 C=CCN(C(=O)OCc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288876 19063 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 848 13 1 8 7.0 C=CCN(C(=O)OCc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
46191233 202126 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 575 6 0 5 4.6 Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL593027 202126 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 575 6 0 5 4.6 Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
118727184 117452 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 578 9 0 5 4.4 Cc1ccc(N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)C(=O)C2CCN(S(C)(=O)=O)CC2)cc1Cl 10.1016/j.bmc.2014.12.052
CHEMBL3397995 117452 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 578 9 0 5 4.4 Cc1ccc(N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)C(=O)C2CCN(S(C)(=O)=O)CC2)cc1Cl 10.1016/j.bmc.2014.12.052
15950679 92712 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 495 6 0 4 5.9 O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(-c3cncnc3)cc2)CC1 10.1021/jm401101p
CHEMBL2435868 92712 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 495 6 0 4 5.9 O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(-c3cncnc3)cc2)CC1 10.1021/jm401101p
49798156 10577 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 607 9 1 4 5.0 C=CCN(C(=O)Cc1ccc(Br)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1169819 10577 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 607 9 1 4 5.0 C=CCN(C(=O)Cc1ccc(Br)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
72712161 92714 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 494 6 0 3 6.5 O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(-c3cccnc3)cc2)CC1 10.1021/jm401101p
CHEMBL2435870 92714 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 494 6 0 3 6.5 O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(-c3cccnc3)cc2)CC1 10.1021/jm401101p
10280945 12844 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 517 9 1 4 5.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1021/jm060051s
CHEMBL1188557 12844 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 517 9 1 4 5.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1021/jm060051s
CHEMBL536743 12844 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 517 9 1 4 5.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1021/jm060051s
10277467 13089 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 443 7 1 5 3.0 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc3c(c1)OCCO3)CC2 10.1021/jm060051s
CHEMBL1190217 13089 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 443 7 1 5 3.0 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc3c(c1)OCCO3)CC2 10.1021/jm060051s
CHEMBL540366 13089 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 443 7 1 5 3.0 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc3c(c1)OCCO3)CC2 10.1021/jm060051s
21064331 14382 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 533 9 1 4 6.3 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Sc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1172871 14382 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 533 9 1 4 6.3 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Sc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1200224 14382 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 533 9 1 4 6.3 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Sc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
46226120 14151 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 547 10 1 4 6.3 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Sc3ccccc3)c1)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL1198114 14151 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 547 10 1 4 6.3 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Sc3ccccc3)c1)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL596165 14151 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 547 10 1 4 6.3 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Sc3ccccc3)c1)CC2 10.1016/j.bmcl.2009.11.018
122185611 122976 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 566 8 2 2 6.7 Cc1c(CNC(=O)c2ccc(-c3ccccc3)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(-c3ccccc3)cc1)CCC2 10.1016/j.bmcl.2015.06.029
CHEMBL3604297 122976 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 566 8 2 2 6.7 Cc1c(CNC(=O)c2ccc(-c3ccccc3)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(-c3ccccc3)cc1)CCC2 10.1016/j.bmcl.2015.06.029
CHEMBL3606030 122976 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 566 8 2 2 6.7 Cc1c(CNC(=O)c2ccc(-c3ccccc3)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(-c3ccccc3)cc1)CCC2 10.1016/j.bmcl.2015.06.029
52945865 19079 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 838 13 1 6 7.9 C=CCN(C(=O)Cc1ccc(OC(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288920 19079 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 838 13 1 6 7.9 C=CCN(C(=O)Cc1ccc(OC(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
168271219 190539 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 483 8 1 6 5.7 Cc1ccsc1[C@H](CCN1[C@@H]2CC[C@H]1C[C@H](n1c(C)nnc1C(C)C)C2)NC(=O)C1CCCC1 10.1021/acs.jmedchem.2c01383
CHEMBL5178121 190539 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 483 8 1 6 5.7 Cc1ccsc1[C@H](CCN1[C@@H]2CC[C@H]1C[C@H](n1c(C)nnc1C(C)C)C2)NC(=O)C1CCCC1 10.1021/acs.jmedchem.2c01383
11237537 192207 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 509 7 1 5 4.3 CC(=O)N[C@@H](CCN1C2CCC1CC(n1c(C)nc3c1CCN(C(=O)C(C)C)C3)C2)c1cccc(F)c1 10.1021/acs.jmedchem.2c01383
CHEMBL5203084 192207 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 509 7 1 5 4.3 CC(=O)N[C@@H](CCN1C2CCC1CC(n1c(C)nc3c1CCN(C(=O)C(C)C)C3)C2)c1cccc(F)c1 10.1021/acs.jmedchem.2c01383
10277467 13089 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 443 7 1 5 3.0 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc3c(c1)OCCO3)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL1190217 13089 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 443 7 1 5 3.0 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc3c(c1)OCCO3)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL540366 13089 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 443 7 1 5 3.0 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc3c(c1)OCCO3)CC2 10.1016/j.bmcl.2009.11.018
53324598 60132 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assayAntagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL1668020 60132 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assayAntagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL1739382 60132 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assayAntagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
46225512 204057 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 489 5 0 5 3.3 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C(C)(C)C)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL605727 204057 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 489 5 0 5 3.3 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C(C)(C)C)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
122185639 122987 None 0 Human Functional pIC50 = 4.7 4.7 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 442 6 2 2 4.0 Cc1ccc(C(=O)NCc2c(C)c(CNC(=O)c3ccc(C)cc3)c3[n+](c2C)CCC3)cc1 10.1016/j.bmcl.2015.06.029
CHEMBL3604311 122987 None 0 Human Functional pIC50 = 4.7 4.7 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 442 6 2 2 4.0 Cc1ccc(C(=O)NCc2c(C)c(CNC(=O)c3ccc(C)cc3)c3[n+](c2C)CCC3)cc1 10.1016/j.bmcl.2015.06.029
CHEMBL3606112 122987 None 0 Human Functional pIC50 = 4.7 4.7 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 442 6 2 2 4.0 Cc1ccc(C(=O)NCc2c(C)c(CNC(=O)c3ccc(C)cc3)c3[n+](c2C)CCC3)cc1 10.1016/j.bmcl.2015.06.029
11466794 69223 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 535 9 1 5 5.9 CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2ccccc2)c2ccc(C#N)cc2)CC1 10.1016/j.bmcl.2011.09.133
CHEMBL1926875 69223 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 535 9 1 5 5.9 CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2ccccc2)c2ccc(C#N)cc2)CC1 10.1016/j.bmcl.2011.09.133
172449421 195963 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 60 mins by Fluo-4 AM calcium flux based FLIPR assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 60 mins by Fluo-4 AM calcium flux based FLIPR assay
ChEMBL 3969 154 46 55 -8.1 CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(C(C)=O)CC3)c3ccc(C)c(Cl)c3)CC2)cc1)C(N)=O)[C@@H](C)CC 10.1016/j.ejmech.2023.115294
CHEMBL5414303 195963 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 60 mins by Fluo-4 AM calcium flux based FLIPR assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 60 mins by Fluo-4 AM calcium flux based FLIPR assay
ChEMBL 3969 154 46 55 -8.1 CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(C(C)=O)CC3)c3ccc(C)c(Cl)c3)CC2)cc1)C(N)=O)[C@@H](C)CC 10.1016/j.ejmech.2023.115294
122185633 122984 None 0 Human Functional pIC50 = 4.7 4.7 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 506 8 2 4 4.8 CSc1ccc(C(=O)NCc2c(C)c(CNC(=O)c3ccc(SC)cc3)c3[n+](c2C)CCC3)cc1 10.1016/j.bmcl.2015.06.029
CHEMBL3604308 122984 None 0 Human Functional pIC50 = 4.7 4.7 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 506 8 2 4 4.8 CSc1ccc(C(=O)NCc2c(C)c(CNC(=O)c3ccc(SC)cc3)c3[n+](c2C)CCC3)cc1 10.1016/j.bmcl.2015.06.029
CHEMBL3606102 122984 None 0 Human Functional pIC50 = 4.7 4.7 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 506 8 2 4 4.8 CSc1ccc(C(=O)NCc2c(C)c(CNC(=O)c3ccc(SC)cc3)c3[n+](c2C)CCC3)cc1 10.1016/j.bmcl.2015.06.029
46225428 202397 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 503 5 0 5 3.7 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C(C)(C)C)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL594914 202397 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 503 5 0 5 3.7 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C(C)(C)C)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
76335572 104644 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 570 10 1 4 4.5 CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCCc3ccc(F)cc3)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
CHEMBL3104689 104644 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 570 10 1 4 4.5 CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCCc3ccc(F)cc3)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
90656340 111191 None 0 Human Functional pIC50 = 4.7 4.7 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 461 8 1 7 3.8 COc1ccc(CN2CCN(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 10.1016/j.bmcl.2014.03.073
CHEMBL3263319 111191 None 0 Human Functional pIC50 = 4.7 4.7 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 461 8 1 7 3.8 COc1ccc(CN2CCN(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 10.1016/j.bmcl.2014.03.073
57402800 69231 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 565 10 1 6 5.9 COc1ccc(N(Cc2cccc(C#N)c2)C2CCN(C(C)CCNC(=O)c3c(Cl)cncc3Cl)CC2)cc1 10.1016/j.bmcl.2011.09.133
CHEMBL1926885 69231 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 565 10 1 6 5.9 COc1ccc(N(Cc2cccc(C#N)c2)C2CCN(C(C)CCNC(=O)c3c(Cl)cncc3Cl)CC2)cc1 10.1016/j.bmcl.2011.09.133
53319405 57219 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 499 7 1 6 2.9 CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(S(C)(=O)=O)CC3)C2)c1ccccc1 10.1021/jm100978n
CHEMBL1649918 57219 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 499 7 1 6 2.9 CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(S(C)(=O)=O)CC3)C2)c1ccccc1 10.1021/jm100978n
46191232 202130 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 618 6 0 4 5.7 Cc1cc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL593046 202130 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 618 6 0 4 5.7 Cc1cc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
3008902 205137 None 0 Human Functional pIC50 = 8.7 8.7 -1 2
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 512 6 0 4 5.1 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL61536 205137 None 0 Human Functional pIC50 = 8.7 8.7 -1 2
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 512 6 0 4 5.1 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
3008908 205125 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 439 4 1 3 5.5 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(Cl)cc3)CC2)CC1 10.1021/jm031046g
CHEMBL61466 205125 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 439 4 1 3 5.5 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(Cl)cc3)CC2)CC1 10.1021/jm031046g
11570778 141006 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 608 10 1 5 4.4 CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3cccc(C(N)=O)c3)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
CHEMBL382252 141006 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 608 10 1 5 4.4 CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3cccc(C(N)=O)c3)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
44194589 10890 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 608 10 2 6 2.9 C=CCN(C(=O)Cc1ccc(S(N)(=O)=O)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172624 10890 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 608 10 2 6 2.9 C=CCN(C(=O)Cc1ccc(S(N)(=O)=O)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
3002977 2460 None 43 Human Functional pIC50 = 8.7 8.7 2 4
Antagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysisAntagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysis
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmc.2016.09.059
3002977.0 2460 None 43 Human Functional pIC50 = 8.7 8.7 2 4
Antagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysisAntagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysis
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmc.2016.09.059
803 2460 None 43 Human Functional pIC50 = 8.7 8.7 2 4
Antagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysisAntagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysis
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmc.2016.09.059
806 2460 None 43 Human Functional pIC50 = 8.7 8.7 2 4
Antagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysisAntagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysis
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmc.2016.09.059
CHEMBL1201187 2460 None 43 Human Functional pIC50 = 8.7 8.7 2 4
Antagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysisAntagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysis
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmc.2016.09.059
CHEMBL256907 2460 None 43 Human Functional pIC50 = 8.7 8.7 2 4
Antagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysisAntagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysis
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmc.2016.09.059
CHEMBL584744 2460 None 43 Human Functional pIC50 = 8.7 8.7 2 4
Antagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysisAntagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysis
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmc.2016.09.059
DB04835 2460 None 43 Human Functional pIC50 = 8.7 8.7 2 4
Antagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysisAntagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysis
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmc.2016.09.059
3013689 77069 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 583 9 0 4 5.5 CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
CHEMBL207190 77069 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 583 9 0 4 5.5 CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
11700429 103600 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Inhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cellsInhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cells
ChEMBL 710 17 1 7 9.1 CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCCN3CC(C)C)cc1 10.1021/jm0509703
CHEMBL3085311 103600 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Inhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cellsInhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cells
ChEMBL 710 17 1 7 9.1 CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCCN3CC(C)C)cc1 10.1021/jm0509703
3002977 2460 None 43 Human Functional pIC50 = 8.7 8.7 2 4
Antagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challengeAntagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challenge
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1039/c3md00080j
3002977.0 2460 None 43 Human Functional pIC50 = 8.7 8.7 2 4
Antagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challengeAntagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challenge
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1039/c3md00080j
803 2460 None 43 Human Functional pIC50 = 8.7 8.7 2 4
Antagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challengeAntagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challenge
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1039/c3md00080j
806 2460 None 43 Human Functional pIC50 = 8.7 8.7 2 4
Antagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challengeAntagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challenge
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1039/c3md00080j
CHEMBL1201187 2460 None 43 Human Functional pIC50 = 8.7 8.7 2 4
Antagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challengeAntagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challenge
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1039/c3md00080j
CHEMBL256907 2460 None 43 Human Functional pIC50 = 8.7 8.7 2 4
Antagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challengeAntagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challenge
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1039/c3md00080j
CHEMBL584744 2460 None 43 Human Functional pIC50 = 8.7 8.7 2 4
Antagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challengeAntagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challenge
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1039/c3md00080j
DB04835 2460 None 43 Human Functional pIC50 = 8.7 8.7 2 4
Antagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challengeAntagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challenge
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1039/c3md00080j
457871 100777 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 483 4 1 3 5.6 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(Br)cc3)CC2)CC1 10.1021/jm031046g
CHEMBL292625 100777 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 483 4 1 3 5.6 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(Br)cc3)CC2)CC1 10.1021/jm031046g
3008928 205114 None 0 Human Functional pIC50 = 8.7 8.7 -1 2
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 483 5 0 5 5.4 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL61424 205114 None 0 Human Functional pIC50 = 8.7 8.7 -1 2
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 483 5 0 5 5.4 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
3002977 2460 None 43 Human Functional pIC50 = 8.7 8.7 2 4
Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C nan
3002977.0 2460 None 43 Human Functional pIC50 = 8.7 8.7 2 4
Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C nan
803 2460 None 43 Human Functional pIC50 = 8.7 8.7 2 4
Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C nan
806 2460 None 43 Human Functional pIC50 = 8.7 8.7 2 4
Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C nan
CHEMBL1201187 2460 None 43 Human Functional pIC50 = 8.7 8.7 2 4
Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C nan
CHEMBL256907 2460 None 43 Human Functional pIC50 = 8.7 8.7 2 4
Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C nan
CHEMBL584744 2460 None 43 Human Functional pIC50 = 8.7 8.7 2 4
Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C nan
DB04835 2460 None 43 Human Functional pIC50 = 8.7 8.7 2 4
Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C nan
5275765 138321 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 572 9 1 4 5.0 CC(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(C(N)=O)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
CHEMBL377026 138321 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 572 9 1 4 5.0 CC(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(C(N)=O)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
145984727 165662 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 483 8 1 6 5.8 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCCCC1)c1cccs1 10.1021/acs.jmedchem.8b01077
CHEMBL4242114 165662 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 483 8 1 6 5.8 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCCCC1)c1cccs1 10.1021/acs.jmedchem.8b01077
145986021 165892 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 505 8 1 6 5.6 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)C1)c1cccs1 10.1021/acs.jmedchem.8b01077
CHEMBL4248009 165892 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 505 8 1 6 5.6 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)C1)c1cccs1 10.1021/acs.jmedchem.8b01077
59458103 92750 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 537 8 1 4 5.4 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
CHEMBL2435906 92750 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 537 8 1 4 5.4 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
3008927 201314 None 0 Human Functional pIC50 = 8.6 8.6 -2 2
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 482 5 0 4 6.0 Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL58387 201314 None 0 Human Functional pIC50 = 8.6 8.6 -2 2
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 482 5 0 4 6.0 Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
3008914 203466 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 573 6 0 3 7.2 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccc(Br)cc3)CC2)CC1 10.1021/jm031046g
CHEMBL60225 203466 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 573 6 0 3 7.2 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccc(Br)cc3)CC2)CC1 10.1021/jm031046g
11513274 103598 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Inhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cellsInhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cells
ChEMBL 734 17 1 9 8.0 CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCN3Cc2cnn(C)c2)cc1 10.1021/jm0509703
CHEMBL3085309 103598 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Inhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cellsInhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cells
ChEMBL 734 17 1 9 8.0 CCCCOCCOc1ccc(-c2ccc3c(c2)/C=C(/C(=O)Nc2ccc([S@@+]([O-])Cc4cncn4CCC)cc2)CCCN3Cc2cnn(C)c2)cc1 10.1021/jm0509703
57397598 69236 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 515 10 1 6 5.1 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)ccnc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
CHEMBL1926890 69236 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 515 10 1 6 5.1 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)ccnc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
59458247 92756 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 571 8 1 5 6.2 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccsc2)CC1 10.1021/jm401101p
CHEMBL2435912 92756 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 571 8 1 5 6.2 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccsc2)CC1 10.1021/jm401101p
3008923 201355 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 521 5 0 3 7.3 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2c(Cl)cccc2Cl)CC1 10.1021/jm031046g
CHEMBL58441 201355 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 521 5 0 3 7.3 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2c(Cl)cccc2Cl)CC1 10.1021/jm031046g
3008908 205125 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 439 4 1 3 5.5 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(Cl)cc3)CC2)CC1 10.1021/jm031046g
CHEMBL61466 205125 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 439 4 1 3 5.5 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(Cl)cc3)CC2)CC1 10.1021/jm031046g
168268916 190113 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 549 10 1 7 5.9 COCc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccsc1 10.1021/acs.jmedchem.2c01383
CHEMBL5171331 190113 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 549 10 1 7 5.9 COCc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccsc1 10.1021/acs.jmedchem.2c01383
122668213 165678 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 483 8 1 6 5.7 Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCCC2)s1 10.1021/acs.jmedchem.8b01077
CHEMBL4242489 165678 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 483 8 1 6 5.7 Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCCC2)s1 10.1021/acs.jmedchem.8b01077
145984502 165698 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 517 8 1 6 5.8 Cc1nnc(C2CC2)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccsc1 10.1021/acs.jmedchem.8b01077
CHEMBL4242913 165698 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 517 8 1 6 5.8 Cc1nnc(C2CC2)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccsc1 10.1021/acs.jmedchem.8b01077
145984829 165913 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 491 8 1 6 5.2 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CC(F)(F)C1)c1cccs1 10.1021/acs.jmedchem.8b01077
CHEMBL4248472 165913 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 491 8 1 6 5.2 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CC(F)(F)C1)c1cccs1 10.1021/acs.jmedchem.8b01077
52948296 19083 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 810 13 2 6 7.6 CCCCN(C(=O)NCc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288924 19083 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 810 13 2 6 7.6 CCCCN(C(=O)NCc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
3008917 205241 None 3 Human Functional pIC50 = 8.6 8.6 -6 2
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 481 5 0 3 6.6 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL62152 205241 None 3 Human Functional pIC50 = 8.6 8.6 -6 2
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 481 5 0 3 6.6 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
49798086 10827 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 578 9 2 4 5.0 C=CCN(C(=O)NCc1ccc(Cl)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172046 10827 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 578 9 2 4 5.0 C=CCN(C(=O)NCc1ccc(Cl)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
11577846 77149 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 581 8 0 4 5.4 CC(=O)N1CCC(C(=O)N(CCCN2CCC([S+]([O-])c3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
CHEMBL207654 77149 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 581 8 0 4 5.4 CC(=O)N1CCC(C(=O)N(CCCN2CCC([S+]([O-])c3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
145985461 165593 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 505 8 1 6 5.5 CCc1nnc(C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccsc1 10.1021/acs.jmedchem.8b01077
CHEMBL4240475 165593 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 505 8 1 6 5.5 CCc1nnc(C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccsc1 10.1021/acs.jmedchem.8b01077
126567264 165904 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 533 8 1 6 6.3 Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)s1 10.1021/acs.jmedchem.8b01077
CHEMBL4248282 165904 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 533 8 1 6 6.3 Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)s1 10.1021/acs.jmedchem.8b01077
3008932 205103 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 560 6 0 6 6.5 Cc1nc(-c2ccncc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL61373 205103 None 0 Human Functional pIC50 = 8.6 8.6 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 560 6 0 6 6.5 Cc1nc(-c2ccncc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
3008904 202422 None 0 Human Functional pIC50 = 8.6 8.6 1 2
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 537 6 0 5 5.0 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3cccc(C#N)c3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL59511 202422 None 0 Human Functional pIC50 = 8.6 8.6 1 2
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 537 6 0 5 5.0 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3cccc(C#N)c3)c3ccccc3)CC2)CC1 10.1021/jm031046g
145983733 165567 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 571 8 1 6 6.5 O=C(N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@@H](n1c(C3CC3)nnc1C(F)(F)F)C2)c1ccsc1)C1CCC(F)(F)CC1 10.1021/acs.jmedchem.8b01077
CHEMBL4239790 165567 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 571 8 1 6 6.5 O=C(N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@@H](n1c(C3CC3)nnc1C(F)(F)F)C2)c1ccsc1)C1CCC(F)(F)CC1 10.1021/acs.jmedchem.8b01077
145982775 165644 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 483 8 1 7 4.6 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(=O)C1)c1cccs1 10.1021/acs.jmedchem.8b01077
CHEMBL4241721 165644 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 483 8 1 7 4.6 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(=O)C1)c1cccs1 10.1021/acs.jmedchem.8b01077
145985042 165762 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 517 8 1 6 5.8 Cc1nnc(C2CC2)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cccs1 10.1021/acs.jmedchem.8b01077
CHEMBL4244672 165762 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 517 8 1 6 5.8 Cc1nnc(C2CC2)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cccs1 10.1021/acs.jmedchem.8b01077
72711955 92705 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 574 9 1 5 5.4 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(Cc3ccccn3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
CHEMBL2435861 92705 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 574 9 1 5 5.4 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(Cc3ccccn3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
16663418 10817 None 24 Human Functional pIC50 = 8.5 8.5 -1 2
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 590 10 1 7 4.7 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172035 10817 None 24 Human Functional pIC50 = 8.5 8.5 -1 2
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 590 10 1 7 4.7 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
3008930 201136 None 0 Human Functional pIC50 = 8.5 8.5 1 2
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 499 5 0 5 4.6 Cc1nc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL58004 201136 None 0 Human Functional pIC50 = 8.5 8.5 1 2
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 499 5 0 5 4.6 Cc1nc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
16663418 10817 None 24 Human Functional pIC50 = 8.5 8.5 -1 2
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 590 10 1 7 4.7 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.046
CHEMBL1172035 10817 None 24 Human Functional pIC50 = 8.5 8.5 -1 2
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 590 10 1 7 4.7 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.046
44194676 10833 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 637 11 3 6 3.3 C=CCN(C(=O)NCc1ccc(S(=O)(=O)NC)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172052 10833 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 637 11 3 6 3.3 C=CCN(C(=O)NCc1ccc(S(=O)(=O)NC)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
49864973 15792 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 640 11 2 6 3.3 C=CCN(C(=O)Cc1ccc(S(=O)(=O)NC)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2cccc(F)c2)CC1 10.1016/j.bmcl.2010.05.046
CHEMBL1222771 15792 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 640 11 2 6 3.3 C=CCN(C(=O)Cc1ccc(S(=O)(=O)NC)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2cccc(F)c2)CC1 10.1016/j.bmcl.2010.05.046
3500 1526 None 13 Human Functional pIC50 = 7.7 7.7 245 2
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 483 7 1 5 3.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C21CCN(CC2)Cc1ccc2c(c1)OCCO2 10.1021/jm060051s
491774 1526 None 13 Human Functional pIC50 = 7.7 7.7 245 2
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 483 7 1 5 3.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C21CCN(CC2)Cc1ccc2c(c1)OCCO2 10.1021/jm060051s
CHEMBL1196395 1526 None 13 Human Functional pIC50 = 7.7 7.7 245 2
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 483 7 1 5 3.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C21CCN(CC2)Cc1ccc2c(c1)OCCO2 10.1021/jm060051s
49798083 10825 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 623 9 1 5 5.6 C=CCN(C(=O)OCc1ccc(Br)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172044 10825 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 623 9 1 5 5.6 C=CCN(C(=O)OCc1ccc(Br)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
52948295 19070 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 780 11 2 6 7.3 C=CCN(C(=O)Nc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288911 19070 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 780 11 2 6 7.3 C=CCN(C(=O)Nc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
145983844 165897 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 484 8 2 7 3.5 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)[C@@H]1CCC(=O)N1)c1cccs1 10.1021/acs.jmedchem.8b01077
CHEMBL4248119 165897 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 484 8 2 7 3.5 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)[C@@H]1CCC(=O)N1)c1cccs1 10.1021/acs.jmedchem.8b01077
72713859 92755 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 532 8 1 5 4.9 Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccccc2)CC1 10.1021/jm401101p
CHEMBL2435911 92755 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 532 8 1 5 4.9 Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccccc2)CC1 10.1021/jm401101p
3008919 100819 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 453 5 0 3 6.0 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2ccccc2)CC1 10.1021/jm031046g
CHEMBL292894 100819 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 453 5 0 3 6.0 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2ccccc2)CC1 10.1021/jm031046g
10184169 12824 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 441 11 1 3 4.4 CCCN1C(=O)[C@H](CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 10.1021/jm060051s
CHEMBL1188324 12824 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 441 11 1 3 4.4 CCCN1C(=O)[C@H](CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 10.1021/jm060051s
CHEMBL536063 12824 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 441 11 1 3 4.4 CCCN1C(=O)[C@H](CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 10.1021/jm060051s
56661526 66433 None 0 Human Functional pIC50 = 4.7 4.7 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 562 8 3 6 3.5 CCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813447 66433 None 0 Human Functional pIC50 = 4.7 4.7 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 562 8 3 6 3.5 CCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851866 66433 None 0 Human Functional pIC50 = 4.7 4.7 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 562 8 3 6 3.5 CCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
57331340 104634 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 580 10 0 4 5.4 CCN(Cc1ccc(C)cc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
CHEMBL3104677 104634 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 580 10 0 4 5.4 CCN(Cc1ccc(C)cc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
118727182 117450 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 511 8 0 3 6.2 Cc1ccc(N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)C(=O)c2ccc(F)cc2)cc1Cl 10.1016/j.bmc.2014.12.052
CHEMBL3397993 117450 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 511 8 0 3 6.2 Cc1ccc(N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)C(=O)c2ccc(F)cc2)cc1Cl 10.1016/j.bmc.2014.12.052
46191232 202130 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 618 6 0 4 5.7 Cc1cc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL593046 202130 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 618 6 0 4 5.7 Cc1cc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
21927139 14384 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 518 9 1 5 5.3 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)nc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1200232 14384 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 518 9 1 5 5.3 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)nc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL3216934 14384 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 518 9 1 5 5.3 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)nc1)CC2 10.1016/j.bmc.2010.05.057
168293785 192285 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 576 9 1 8 4.2 Cc1csc([C@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCN(S(C)(=O)=O)CC2)c1 10.1021/acs.jmedchem.2c01383
CHEMBL5204027 192285 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 576 9 1 8 4.2 Cc1csc([C@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCN(S(C)(=O)=O)CC2)c1 10.1021/acs.jmedchem.2c01383
52944618 19080 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 797 13 2 6 6.1 C=CCN(C(=O)Cc1ccc(C(N)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288921 19080 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 797 13 2 6 6.1 C=CCN(C(=O)Cc1ccc(C(N)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
10186729 13958 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 493 9 2 5 4.0 CCCCN1C(=O)[C@@H]([C@@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
CHEMBL1196666 13958 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 493 9 2 5 4.0 CCCCN1C(=O)[C@@H]([C@@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
CHEMBL557789 13958 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 493 9 2 5 4.0 CCCCN1C(=O)[C@@H]([C@@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
56678576 66649 None 0 Human Functional pIC50 = 4.7 4.7 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 576 9 3 6 3.9 CCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813449 66649 None 0 Human Functional pIC50 = 4.7 4.7 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 576 9 3 6 3.9 CCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1852754 66649 None 0 Human Functional pIC50 = 4.7 4.7 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 576 9 3 6 3.9 CCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
118727181 117449 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 431 7 0 3 4.7 CC(=O)N(CCCN1CCN(Cc2ccc(F)cc2)CC1C)c1ccc(C)c(Cl)c1 10.1016/j.bmc.2014.12.052
CHEMBL3397992 117449 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 431 7 0 3 4.7 CC(=O)N(CCCN1CCN(Cc2ccc(F)cc2)CC1C)c1ccc(C)c(Cl)c1 10.1016/j.bmc.2014.12.052
3008911 101035 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 458 4 1 4 5.4 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3cccc4ccn(C)c34)CC2)CC1 10.1021/jm031046g
CHEMBL294271 101035 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 458 4 1 4 5.4 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3cccc4ccn(C)c34)CC2)CC1 10.1021/jm031046g
52947063 19061 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 788 12 1 6 7.7 C=CCN(C(=O)OCc1ccc(F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288874 19061 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 788 12 1 6 7.7 C=CCN(C(=O)OCc1ccc(F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
46225533 202133 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 590 6 0 4 4.9 Cc1cc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL593080 202133 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 590 6 0 4 4.9 Cc1cc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
73355478 92721 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 509 7 0 3 7.3 O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(Oc3ccccc3)cc2)CC1 10.1021/jm401101p
CHEMBL2435877 92721 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 509 7 0 3 7.3 O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(Oc3ccccc3)cc2)CC1 10.1021/jm401101p
49798081 10823 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 563 9 1 5 5.0 C=CCN(C(=O)OCc1ccc(F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172042 10823 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 563 9 1 5 5.0 C=CCN(C(=O)OCc1ccc(F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
16659334 14009 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assayAntagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay
ChEMBL 493 9 2 5 4.0 CCCCN1C(=O)[C@@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL1197042 14009 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assayAntagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay
ChEMBL 493 9 2 5 4.0 CCCCN1C(=O)[C@@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL559168 14009 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assayAntagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay
ChEMBL 493 9 2 5 4.0 CCCCN1C(=O)[C@@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
3008931 205104 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 559 6 0 5 7.1 Cc1nc(-c2ccccc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL61374 205104 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 559 6 0 5 7.1 Cc1nc(-c2ccccc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
90656333 111132 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 509 7 1 6 4.6 CC(C)Oc1ccc(N2CCN(Cc3ccc(Br)cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.bmcl.2014.03.073
CHEMBL3263029 111132 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 509 7 1 6 4.6 CC(C)Oc1ccc(N2CCN(Cc3ccc(Br)cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.bmcl.2014.03.073
56678574 66400 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 593 10 4 7 3.6 CCCCN1C(=O)[C@@H]([C@@H](O)C2CCC(O)CC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813443 66400 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 593 10 4 7 3.6 CCCCN1C(=O)[C@@H]([C@@H](O)C2CCC(O)CC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851694 66400 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 593 10 4 7 3.6 CCCCN1C(=O)[C@@H]([C@@H](O)C2CCC(O)CC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
56664937 66432 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 549 8 3 6 3.8 CCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813446 66432 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 549 8 3 6 3.8 CCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851865 66432 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 549 8 3 6 3.8 CCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
118727190 117458 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 521 7 0 5 4.3 CC(=O)N1CCC(C(=O)N(CCCN2CCN(c3ccc(C#N)cc3)CC2)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
CHEMBL3398001 117458 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 521 7 0 5 4.3 CC(=O)N1CCC(C(=O)N(CCCN2CCN(c3ccc(C#N)cc3)CC2)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
122185637 122986 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 470 8 2 2 4.5 CCc1ccc(C(=O)NCc2c(C)c(CNC(=O)c3ccc(CC)cc3)c3[n+](c2C)CCC3)cc1 10.1016/j.bmcl.2015.06.029
CHEMBL3604310 122986 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 470 8 2 2 4.5 CCc1ccc(C(=O)NCc2c(C)c(CNC(=O)c3ccc(CC)cc3)c3[n+](c2C)CCC3)cc1 10.1016/j.bmcl.2015.06.029
CHEMBL3606111 122986 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 470 8 2 2 4.5 CCc1ccc(C(=O)NCc2c(C)c(CNC(=O)c3ccc(CC)cc3)c3[n+](c2C)CCC3)cc1 10.1016/j.bmcl.2015.06.029
52948264 19059 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 815 13 1 8 7.5 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288872 19059 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 815 13 1 8 7.5 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
46225532 202129 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 547 6 0 5 3.8 Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL593042 202129 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 547 6 0 5 3.8 Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
44404643 72246 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Inhibition of MIP-1beta stimulated calcium transients in CCR5-expressing CHO cellsInhibition of MIP-1beta stimulated calcium transients in CCR5-expressing CHO cells
ChEMBL 611 12 1 6 4.5 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC(c2ccccc2)c2ccc(NS(C)(=O)=O)cc2)CC1 10.1016/j.bmcl.2005.08.014
CHEMBL198114 72246 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Inhibition of MIP-1beta stimulated calcium transients in CCR5-expressing CHO cellsInhibition of MIP-1beta stimulated calcium transients in CCR5-expressing CHO cells
ChEMBL 611 12 1 6 4.5 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC(c2ccccc2)c2ccc(NS(C)(=O)=O)cc2)CC1 10.1016/j.bmcl.2005.08.014
3008930 201136 None 0 Human Functional pIC50 = 7.6 7.6 1 2
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 499 5 0 5 4.6 Cc1nc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL58004 201136 None 0 Human Functional pIC50 = 7.6 7.6 1 2
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 499 5 0 5 4.6 Cc1nc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
145983159 166024 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 497 8 1 7 4.8 Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2=CCOCC2)s1 10.1021/acs.jmedchem.8b01077
CHEMBL4250560 166024 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 497 8 1 7 4.8 Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2=CCOCC2)s1 10.1021/acs.jmedchem.8b01077
3008932 205103 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Migration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells oractivated human peripheral blood lymphocytesMigration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells oractivated human peripheral blood lymphocytes
ChEMBL 560 6 0 6 6.5 Cc1nc(-c2ccncc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL61373 205103 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Migration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells oractivated human peripheral blood lymphocytesMigration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells oractivated human peripheral blood lymphocytes
ChEMBL 560 6 0 6 6.5 Cc1nc(-c2ccncc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
72711506 92746 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 511 8 1 4 4.8 CCN1C[C@@H](c2ccccc2)N(C2CCN(C(C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)C1=O 10.1021/jm401101p
CHEMBL2435902 92746 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 511 8 1 4 4.8 CCN1C[C@@H](c2ccccc2)N(C2CCN(C(C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)C1=O 10.1021/jm401101p
162674876 183441 None 0 Human Functional pIC50 = 5.6 5.6 -109 2
Antagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysisAntagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysis
ChEMBL 1169 26 7 15 5.8 Cc1nnc(C(C)C)n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(=O)NCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)cc1 10.1016/j.bmc.2016.09.059
CHEMBL4797451 183441 None 0 Human Functional pIC50 = 5.6 5.6 -109 2
Antagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysisAntagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysis
ChEMBL 1169 26 7 15 5.8 Cc1nnc(C(C)C)n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(=O)NCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)cc1 10.1016/j.bmc.2016.09.059
46225428 202397 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 503 5 0 5 3.7 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C(C)(C)C)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL594914 202397 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 503 5 0 5 3.7 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C(C)(C)C)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
52948295 19070 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 780 11 2 6 7.3 C=CCN(C(=O)Nc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288911 19070 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 780 11 2 6 7.3 C=CCN(C(=O)Nc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
118727173 117441 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 538 8 0 4 5.1 CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(C)cc3)CC2C)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
CHEMBL3397984 117441 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 538 8 0 4 5.1 CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(C)cc3)CC2C)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
118727178 117446 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 528 8 0 4 4.7 CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)c2cccc(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
CHEMBL3397989 117446 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 528 8 0 4 4.7 CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)c2cccc(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
3002977 2460 None 43 Human Functional pIC50 = 7.6 7.6 2 4
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.ejmech.2013.11.013
3002977.0 2460 None 43 Human Functional pIC50 = 7.6 7.6 2 4
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.ejmech.2013.11.013
803 2460 None 43 Human Functional pIC50 = 7.6 7.6 2 4
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.ejmech.2013.11.013
806 2460 None 43 Human Functional pIC50 = 7.6 7.6 2 4
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.ejmech.2013.11.013
CHEMBL1201187 2460 None 43 Human Functional pIC50 = 7.6 7.6 2 4
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.ejmech.2013.11.013
CHEMBL256907 2460 None 43 Human Functional pIC50 = 7.6 7.6 2 4
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.ejmech.2013.11.013
CHEMBL584744 2460 None 43 Human Functional pIC50 = 7.6 7.6 2 4
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.ejmech.2013.11.013
DB04835 2460 None 43 Human Functional pIC50 = 7.6 7.6 2 4
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.ejmech.2013.11.013
57331278 104641 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 572 9 1 4 5.0 CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCc3ccc(Cl)cc3)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
CHEMBL3104684 104641 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 572 9 1 4 5.0 CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCc3ccc(Cl)cc3)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
3008908 205125 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 439 4 1 3 5.5 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(Cl)cc3)CC2)CC1 10.1021/jm031046g
CHEMBL61466 205125 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 439 4 1 3 5.5 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(Cl)cc3)CC2)CC1 10.1021/jm031046g
57331274 104639 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 538 9 1 4 4.4 CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCc3ccccc3)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
CHEMBL3104682 104639 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 538 9 1 4 4.4 CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCc3ccccc3)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
56661524 66452 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 549 10 3 6 3.8 CCCCN1C(=O)[C@@H]([C@H](O)C2CCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813438 66452 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 549 10 3 6 3.8 CCCCN1C(=O)[C@@H]([C@H](O)C2CCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851951 66452 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 549 10 3 6 3.8 CCCCN1C(=O)[C@@H]([C@H](O)C2CCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
16124598 10733 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at CCR5Antagonist activity at CCR5
ChEMBL 472 6 2 5 5.3 O=C(O)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2010.04.142
CHEMBL1171008 10733 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at CCR5Antagonist activity at CCR5
ChEMBL 472 6 2 5 5.3 O=C(O)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2010.04.142
145986205 165756 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 532 8 1 6 5.5 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(F)nc1 10.1021/acs.jmedchem.8b01077
CHEMBL4244470 165756 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 532 8 1 6 5.5 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(F)nc1 10.1021/acs.jmedchem.8b01077
76313867 104649 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 566 10 0 4 4.9 CCN(C(=O)Cc1ccccc1)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
CHEMBL3104694 104649 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 566 10 0 4 4.9 CCN(C(=O)Cc1ccccc1)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
46837553 103462 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated GTPgammaS binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated GTPgammaS binding by scintillation proximity assay
ChEMBL 569 10 1 6 6.2 Cc1nnc(C(C)C)n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)COc1ccccc1)c1ccc(C(F)(F)F)cc1 10.1016/j.ejmech.2010.03.003
CHEMBL3084747 103462 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated GTPgammaS binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated GTPgammaS binding by scintillation proximity assay
ChEMBL 569 10 1 6 6.2 Cc1nnc(C(C)C)n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)COc1ccccc1)c1ccc(C(F)(F)F)cc1 10.1016/j.ejmech.2010.03.003
90656342 111193 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 488 8 2 7 3.8 CC(=O)Nc1ccc(CN2CCN(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 10.1016/j.bmcl.2014.03.073
CHEMBL3263321 111193 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 488 8 2 7 3.8 CC(=O)Nc1ccc(CN2CCN(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 10.1016/j.bmcl.2014.03.073
118727183 117451 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 542 8 0 4 5.0 CC(=O)N1CCCC(C(=O)N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)c2ccc(C)c(Cl)c2)C1 10.1016/j.bmc.2014.12.052
CHEMBL3397994 117451 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 542 8 0 4 5.0 CC(=O)N1CCCC(C(=O)N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)c2ccc(C)c(Cl)c2)C1 10.1016/j.bmc.2014.12.052
11433338 69222 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 594 10 1 5 7.0 CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2ccccc2)c2ccc(OC(F)(F)F)cc2)CC1 10.1016/j.bmcl.2011.09.133
CHEMBL1926874 69222 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 594 10 1 5 7.0 CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2ccccc2)c2ccc(OC(F)(F)F)cc2)CC1 10.1016/j.bmcl.2011.09.133
52944616 19073 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 827 13 2 7 6.9 C=CCN(C(=O)NCc1ccc(C(=O)OC)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288914 19073 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 827 13 2 7 6.9 C=CCN(C(=O)NCc1ccc(C(=O)OC)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
3008934 201149 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 467 5 0 3 6.2 Cc1cccc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL58101 201149 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 467 5 0 3 6.2 Cc1cccc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
11693007 76288 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 548 8 1 4 5.7 CC(=O)N1CCC(C(=O)N(CCCN2CCC(Nc3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
CHEMBL205851 76288 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 548 8 1 4 5.7 CC(=O)N1CCC(C(=O)N(CCCN2CCC(Nc3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
57331307 104646 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 580 11 0 4 5.1 CCN(CCc1ccccc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
CHEMBL3104691 104646 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 580 11 0 4 5.1 CCN(CCc1ccccc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
23577386 66393 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 626 11 3 7 4.3 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(NS(C)(=O)=O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813435 66393 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 626 11 3 7 4.3 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(NS(C)(=O)=O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851672 66393 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 626 11 3 7 4.3 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(NS(C)(=O)=O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
122185617 122978 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 498 8 2 2 5.6 Cc1c(CNC(=O)c2ccc(C(C)C)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(C(C)C)cc1)CCC2 10.1016/j.bmcl.2015.06.029
CHEMBL3604300 122978 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 498 8 2 2 5.6 Cc1c(CNC(=O)c2ccc(C(C)C)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(C(C)C)cc1)CCC2 10.1016/j.bmcl.2015.06.029
CHEMBL3606050 122978 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 498 8 2 2 5.6 Cc1c(CNC(=O)c2ccc(C(C)C)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(C(C)C)cc1)CCC2 10.1016/j.bmcl.2015.06.029
52949523 19065 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 854 13 1 7 8.4 C=CCN(C(=O)OCc1ccc(OC(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288878 19065 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 854 13 1 7 8.4 C=CCN(C(=O)OCc1ccc(OC(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
46225514 202281 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 537 7 0 6 3.0 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(S(=O)(=O)C4CCCC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL594208 202281 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 537 7 0 6 3.0 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(S(=O)(=O)C4CCCC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
46225512 204057 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 489 5 0 5 3.3 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C(C)(C)C)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL605727 204057 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 489 5 0 5 3.3 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C(C)(C)C)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
126567281 165605 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 520 8 1 7 5.4 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cscn1 10.1021/acs.jmedchem.8b01077
CHEMBL4240742 165605 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 520 8 1 7 5.4 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cscn1 10.1021/acs.jmedchem.8b01077
49864977 15798 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 681 11 3 6 4.0 C=CCN(C(=O)NCc1ccc(S(=O)(=O)NC)cc1)[C@H]1C[C@@H]2CC[C@H](C1)N2C[C@H]1CN(C(=O)C2CCCC2)C[C@]1(O)c1cccc(F)c1 10.1016/j.bmcl.2010.05.046
CHEMBL1222777 15798 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 681 11 3 6 4.0 C=CCN(C(=O)NCc1ccc(S(=O)(=O)NC)cc1)[C@H]1C[C@@H]2CC[C@H](C1)N2C[C@H]1CN(C(=O)C2CCCC2)C[C@]1(O)c1cccc(F)c1 10.1016/j.bmcl.2010.05.046
3008909 201556 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 473 4 1 3 5.9 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(C(F)(F)F)cc3)CC2)CC1 10.1021/jm031046g
CHEMBL58897 201556 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 473 4 1 3 5.9 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(C(F)(F)F)cc3)CC2)CC1 10.1021/jm031046g
491773 12832 None 0 Human Functional pIC50 = 6.6 6.6 67 2
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 455 12 1 3 4.8 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 10.1021/jm060051s
CHEMBL1188399 12832 None 0 Human Functional pIC50 = 6.6 6.6 67 2
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 455 12 1 3 4.8 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 10.1021/jm060051s
CHEMBL536288 12832 None 0 Human Functional pIC50 = 6.6 6.6 67 2
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 455 12 1 3 4.8 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 10.1021/jm060051s
11634966 12883 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 481 11 1 3 5.3 CCCN1C(=O)[C@@H](CC2CCCCC2)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 10.1021/jm060051s
CHEMBL1188808 12883 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 481 11 1 3 5.3 CCCN1C(=O)[C@@H](CC2CCCCC2)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 10.1021/jm060051s
CHEMBL537425 12883 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 481 11 1 3 5.3 CCCN1C(=O)[C@@H](CC2CCCCC2)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 10.1021/jm060051s
491773 12832 None 0 Human Functional pIC50 = 6.6 6.6 67 2
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 455 12 1 3 4.8 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1188399 12832 None 0 Human Functional pIC50 = 6.6 6.6 67 2
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 455 12 1 3 4.8 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL536288 12832 None 0 Human Functional pIC50 = 6.6 6.6 67 2
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 455 12 1 3 4.8 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 10.1016/j.bmc.2010.05.057
90656339 111190 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 446 7 2 7 3.4 CC(C)Oc1ccc(N2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.bmcl.2014.03.073
CHEMBL3263318 111190 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 446 7 2 7 3.4 CC(C)Oc1ccc(N2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.bmcl.2014.03.073
46225515 202111 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 551 6 0 5 4.1 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL592940 202111 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 551 6 0 5 4.1 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
46225350 203615 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 515 7 0 5 3.8 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)CC4CCCC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL603325 203615 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 515 7 0 5 3.8 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)CC4CCCC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
10280945 12844 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 517 9 1 4 5.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
CHEMBL1188557 12844 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 517 9 1 4 5.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
CHEMBL536743 12844 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 517 9 1 4 5.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
10280945 12844 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 517 9 1 4 5.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL1188557 12844 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 517 9 1 4 5.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL536743 12844 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 517 9 1 4 5.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
10280945 12844 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 517 9 1 4 5.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1188557 12844 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 517 9 1 4 5.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL536743 12844 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 517 9 1 4 5.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
21064281 14336 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 596 10 2 6 4.6 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(S(N)(=O)=O)cc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1170877 14336 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 596 10 2 6 4.6 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(S(N)(=O)=O)cc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1200018 14336 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 596 10 2 6 4.6 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(S(N)(=O)=O)cc3)cc1)CC2 10.1016/j.bmc.2010.05.057
10280945 12844 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 517 9 1 4 5.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL1188557 12844 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 517 9 1 4 5.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL536743 12844 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 517 9 1 4 5.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2009.11.018
457871 100777 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 483 4 1 3 5.6 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(Br)cc3)CC2)CC1 10.1021/jm031046g
CHEMBL292625 100777 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 483 4 1 3 5.6 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(Br)cc3)CC2)CC1 10.1021/jm031046g
3008918 201840 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 467 5 0 3 6.3 Cc1ccccc1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL59101 201840 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 467 5 0 3 6.3 Cc1ccccc1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
23577370 66385 None 0 Human Functional pIC50 = 5.6 5.6 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 549 9 3 6 4.6 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813270 66385 None 0 Human Functional pIC50 = 5.6 5.6 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 549 9 3 6 4.6 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851623 66385 None 0 Human Functional pIC50 = 5.6 5.6 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 549 9 3 6 4.6 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
73351059 92848 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 459 8 1 5 5.6 CCOc1ccc(C2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1ccccc1 10.1016/j.ejmech.2013.09.004
CHEMBL2436819 92848 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 459 8 1 5 5.6 CCOc1ccc(C2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1ccccc1 10.1016/j.ejmech.2013.09.004
56678576 66649 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 576 9 3 6 3.9 CCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813449 66649 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 576 9 3 6 3.9 CCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1852754 66649 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 576 9 3 6 3.9 CCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
90656343 111194 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 474 8 1 7 3.9 CC(C)Oc1ccc(N2CCN(Cc3ccc(N(C)C)cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.bmcl.2014.03.073
CHEMBL3263322 111194 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 474 8 1 7 3.9 CC(C)Oc1ccc(N2CCN(Cc3ccc(N(C)C)cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.bmcl.2014.03.073
3008926 204303 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 492 5 1 3 6.5 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2c[nH]c3ccccc23)CC1 10.1021/jm031046g
CHEMBL60711 204303 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 492 5 1 3 6.5 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2c[nH]c3ccccc23)CC1 10.1021/jm031046g
73355550 92828 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 445 7 1 5 5.2 COc1ccc(C2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1ccccc1 10.1016/j.ejmech.2013.09.004
CHEMBL2436720 92828 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 445 7 1 5 5.2 COc1ccc(C2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1ccccc1 10.1016/j.ejmech.2013.09.004
50993435 57215 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 511 8 1 5 5.2 CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(Cc1ccccc1)CC3)C2)c1ccccc1 10.1021/jm100978n
CHEMBL1649914 57215 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 511 8 1 5 5.2 CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(Cc1ccccc1)CC3)C2)c1ccccc1 10.1021/jm100978n
10272003 58896 None 1 Human Functional pIC50 = 5.5 5.5 -4 3
Antagonist activity at CCR5 in human PBMC cells assessed as inhibition of CCL4-induced chemotaxis after 2 hrs trans-well migration assayAntagonist activity at CCR5 in human PBMC cells assessed as inhibition of CCL4-induced chemotaxis after 2 hrs trans-well migration assay
ChEMBL 395 2 2 5 3.4 Cc1nn(C)c2ncc(C(=O)NC(=O)Nc3ccc(F)c(C(F)(F)F)c3)cc12 10.1021/jm1012903
CHEMBL1688888 58896 None 1 Human Functional pIC50 = 5.5 5.5 -4 3
Antagonist activity at CCR5 in human PBMC cells assessed as inhibition of CCL4-induced chemotaxis after 2 hrs trans-well migration assayAntagonist activity at CCR5 in human PBMC cells assessed as inhibition of CCL4-induced chemotaxis after 2 hrs trans-well migration assay
ChEMBL 395 2 2 5 3.4 Cc1nn(C)c2ncc(C(=O)NC(=O)Nc3ccc(F)c(C(F)(F)F)c3)cc12 10.1021/jm1012903
145983098 165832 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 513 7 1 7 4.3 Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)N2CCN(C)CC2)s1 10.1021/acs.jmedchem.8b01077
CHEMBL4246290 165832 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 513 7 1 7 4.3 Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)N2CCN(C)CC2)s1 10.1021/acs.jmedchem.8b01077
118727189 117457 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 542 8 0 4 5.0 CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(F)cc3)C[C@@H]2C)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
CHEMBL3398000 117457 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 542 8 0 4 5.0 CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(F)cc3)C[C@@H]2C)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
57402799 69230 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 603 9 1 5 7.0 CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2cccc(C#N)c2)c2ccc(C(F)(F)F)cc2)CC1 10.1016/j.bmcl.2011.09.133
CHEMBL1926884 69230 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 603 9 1 5 7.0 CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2cccc(C#N)c2)c2ccc(C(F)(F)F)cc2)CC1 10.1016/j.bmcl.2011.09.133
57397597 69232 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 619 10 1 6 6.8 CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2cccc(C#N)c2)c2ccc(OC(F)(F)F)cc2)CC1 10.1016/j.bmcl.2011.09.133
CHEMBL1926886 69232 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 619 10 1 6 6.8 CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2cccc(C#N)c2)c2ccc(OC(F)(F)F)cc2)CC1 10.1016/j.bmcl.2011.09.133
10106 873 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 519 8 1 6 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccsc1)CCN1[C@@H]2CC[C@H]1C[C@@H](C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.8b01077
91820689 873 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 519 8 1 6 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccsc1)CCN1[C@@H]2CC[C@H]1C[C@@H](C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.8b01077
CHEMBL4249798 873 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 519 8 1 6 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccsc1)CCN1[C@@H]2CC[C@H]1C[C@@H](C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.8b01077
145985672 165487 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 501 8 1 6 5.7 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)CC1)c1cccs1 10.1021/acs.jmedchem.8b01077
CHEMBL4237964 165487 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 501 8 1 6 5.7 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)CC1)c1cccs1 10.1021/acs.jmedchem.8b01077
49871007 58830 None 15 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 assessed as inhibition of ERK phosphorylationAntagonist activity at CCR5 assessed as inhibition of ERK phosphorylation
ChEMBL 559 5 0 6 4.8 CCO[C@@H]1Cc2cc(C(F)(F)F)ccc2[C@H]1N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C 10.1021/ml1001536
CHEMBL1688243 58830 None 15 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 assessed as inhibition of ERK phosphorylationAntagonist activity at CCR5 assessed as inhibition of ERK phosphorylation
ChEMBL 559 5 0 6 4.8 CCO[C@@H]1Cc2cc(C(F)(F)F)ccc2[C@H]1N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C 10.1021/ml1001536
49871007 58830 None 15 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxisAntagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxis
ChEMBL 559 5 0 6 4.8 CCO[C@@H]1Cc2cc(C(F)(F)F)ccc2[C@H]1N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C 10.1021/ml1001536
CHEMBL1688243 58830 None 15 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxisAntagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxis
ChEMBL 559 5 0 6 4.8 CCO[C@@H]1Cc2cc(C(F)(F)F)ccc2[C@H]1N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C 10.1021/ml1001536
50992575 57218 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 463 7 1 5 4.4 CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(C)C)CC3)C2)c1ccccc1 10.1021/jm100978n
CHEMBL1649917 57218 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 463 7 1 5 4.4 CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C(C)C)CC3)C2)c1ccccc1 10.1021/jm100978n
46225533 202133 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 590 6 0 4 4.9 Cc1cc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL593080 202133 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 590 6 0 4 4.9 Cc1cc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
3008935 205186 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 468 5 0 4 5.6 Cc1ccnc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL61828 205186 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 468 5 0 4 5.6 Cc1ccnc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
3008913 102031 None 0 Human Functional pIC50 = 8.5 8.5 -1 2
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 495 6 0 3 6.5 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL301454 102031 None 0 Human Functional pIC50 = 8.5 8.5 -1 2
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 495 6 0 3 6.5 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
3013684 77066 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 547 8 0 3 6.1 CC(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
CHEMBL207182 77066 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 547 8 0 3 6.1 CC(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
122668190 165493 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 469 8 1 6 5.4 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCCC1)c1cccs1 10.1021/acs.jmedchem.8b01077
CHEMBL4238063 165493 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 469 8 1 6 5.4 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCCC1)c1cccs1 10.1021/acs.jmedchem.8b01077
49798087 10828 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 589 10 2 6 4.3 C=CCN(C(=O)NCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172047 10828 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 589 10 2 6 4.3 C=CCN(C(=O)NCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
52941648 19076 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 822 12 1 5 8.0 C=CCN(C(=O)Cc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288917 19076 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 822 12 1 5 8.0 C=CCN(C(=O)Cc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
3008929 198093 None 0 Human Functional pIC50 = 8.5 8.5 -1 2
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 498 5 0 4 5.2 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL556314 198093 None 0 Human Functional pIC50 = 8.5 8.5 -1 2
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 498 5 0 4 5.2 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
44194587 10892 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 636 11 1 6 3.5 C=CCN(C(=O)Cc1ccc(S(=O)(=O)N(C)C)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172626 10892 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 636 11 1 6 3.5 C=CCN(C(=O)Cc1ccc(S(=O)(=O)N(C)C)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
73347894 92707 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 574 9 1 5 5.4 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(Cc3cccnc3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
CHEMBL2435863 92707 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 574 9 1 5 5.4 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(Cc3cccnc3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
3008929 198093 None 0 Human Functional pIC50 = 8.5 8.5 -1 2
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 498 5 0 4 5.2 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL556314 198093 None 0 Human Functional pIC50 = 8.5 8.5 -1 2
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 498 5 0 4 5.2 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
49798129 10842 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 529 9 1 4 4.2 C=CCN(C(=O)Cc1ccccc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172157 10842 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 529 9 1 4 4.2 C=CCN(C(=O)Cc1ccccc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
16663418 10817 None 24 Human Functional pIC50 = 8.5 8.5 -1 2
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced calcium elevationAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced calcium elevation
ChEMBL 590 10 1 7 4.7 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172035 10817 None 24 Human Functional pIC50 = 8.5 8.5 -1 2
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced calcium elevationAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced calcium elevation
ChEMBL 590 10 1 7 4.7 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
53319838 58829 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxisAntagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxis
ChEMBL 545 4 0 6 4.4 CO[C@@H]1Cc2cc(C(F)(F)F)ccc2[C@H]1N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C 10.1021/ml1001536
CHEMBL1688242 58829 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxisAntagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxis
ChEMBL 545 4 0 6 4.4 CO[C@@H]1Cc2cc(C(F)(F)F)ccc2[C@H]1N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C 10.1021/ml1001536
3008923 201355 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 521 5 0 3 7.3 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2c(Cl)cccc2Cl)CC1 10.1021/jm031046g
CHEMBL58441 201355 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 521 5 0 3 7.3 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2c(Cl)cccc2Cl)CC1 10.1021/jm031046g
59458245 92710 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 617 10 2 5 5.7 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(Cc3ccc(C(=O)O)cc3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
CHEMBL2435866 92710 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 617 10 2 5 5.7 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(Cc3ccc(C(=O)O)cc3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
72711508 92749 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 539 7 1 4 5.6 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C(C)(C)C)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
CHEMBL2435905 92749 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 539 7 1 4 5.6 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C(C)(C)C)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
49798133 10736 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 563 9 1 4 4.9 C=CCN(C(=O)Cc1ccc(Cl)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1171030 10736 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 563 9 1 4 4.9 C=CCN(C(=O)Cc1ccc(Cl)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
52947091 19071 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 794 12 2 6 7.0 C=CCN(C(=O)NCc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288912 19071 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 794 12 2 6 7.0 C=CCN(C(=O)NCc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
3008924 202159 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 503 5 0 3 7.1 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2cccc3ccccc23)CC1 10.1021/jm031046g
CHEMBL59328 202159 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 503 5 0 3 7.1 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2cccc3ccccc23)CC1 10.1021/jm031046g
3008905 201174 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 537 6 0 5 5.0 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccc(C#N)cc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL58248 201174 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 537 6 0 5 5.0 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccc(C#N)cc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
52947091 19071 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 794 12 2 6 7.0 C=CCN(C(=O)NCc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288912 19071 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 794 12 2 6 7.0 C=CCN(C(=O)NCc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
11585418 76038 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 597 8 0 5 5.1 CC(=O)N1CCC(C(=O)N(CCCN2CCC(S(=O)(=O)c3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
CHEMBL205539 76038 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 597 8 0 5 5.1 CC(=O)N1CCC(C(=O)N(CCCN2CCC(S(=O)(=O)c3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
49864977 15796 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 681 11 3 6 4.0 C=CCN(C(=O)NCc1ccc(S(=O)(=O)NC)cc1)[C@@H]1C[C@@H]2CC[C@H](C1)N2C[C@H]1CN(C(=O)C2CCCC2)C[C@]1(O)c1cccc(F)c1 10.1016/j.bmcl.2010.05.046
CHEMBL1222775 15796 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 681 11 3 6 4.0 C=CCN(C(=O)NCc1ccc(S(=O)(=O)NC)cc1)[C@@H]1C[C@@H]2CC[C@H](C1)N2C[C@H]1CN(C(=O)C2CCCC2)C[C@]1(O)c1cccc(F)c1 10.1016/j.bmcl.2010.05.046
118727179 117447 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 556 7 0 4 4.6 CC(=O)N1CCC(C(=O)N(CCCN2CCN(C(=O)c3ccc(F)cc3)CC2C)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
CHEMBL3397990 117447 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 556 7 0 4 4.6 CC(=O)N1CCC(C(=O)N(CCCN2CCN(C(=O)c3ccc(F)cc3)CC2C)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
11399408 69227 None 1 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 622 9 1 4 7.5 CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2cccc(Cl)c2)c2ccc(Br)cc2)CC1 10.1016/j.bmcl.2011.09.133
CHEMBL1926880 69227 None 1 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 622 9 1 4 7.5 CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2cccc(Cl)c2)c2ccc(Br)cc2)CC1 10.1016/j.bmcl.2011.09.133
46225528 202122 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 619 6 0 5 5.1 Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL592993 202122 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 619 6 0 5 5.1 Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
46225526 202189 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 523 6 0 5 3.3 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL593520 202189 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 523 6 0 5 3.3 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
49864968 15787 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 608 10 1 7 4.9 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccc(F)cc2)CC1 10.1016/j.bmcl.2010.05.046
CHEMBL1222766 15787 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 608 10 1 7 4.9 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccc(F)cc2)CC1 10.1016/j.bmcl.2010.05.046
49864976 15795 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 606 9 2 4 5.2 C=CCN(C(=O)NCc1ccc(F)cc1)[C@@H]1C[C@@H]2CC[C@H](C1)N2C[C@H]1CN(C(=O)C2CCCC2)C[C@]1(O)c1cccc(F)c1 10.1016/j.bmcl.2010.05.046
CHEMBL1222774 15795 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 606 9 2 4 5.2 C=CCN(C(=O)NCc1ccc(F)cc1)[C@@H]1C[C@@H]2CC[C@H](C1)N2C[C@H]1CN(C(=O)C2CCCC2)C[C@]1(O)c1cccc(F)c1 10.1016/j.bmcl.2010.05.046
3008932 205103 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 560 6 0 6 6.5 Cc1nc(-c2ccncc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL61373 205103 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 560 6 0 6 6.5 Cc1nc(-c2ccncc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
118727175 117443 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 542 8 0 4 5.0 CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccccc3F)CC2C)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
CHEMBL3397986 117443 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 542 8 0 4 5.0 CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccccc3F)CC2C)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
11598797 12931 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 481 11 1 3 5.3 CCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 10.1021/jm060051s
CHEMBL1189134 12931 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 481 11 1 3 5.3 CCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 10.1021/jm060051s
CHEMBL538084 12931 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 481 11 1 3 5.3 CCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 10.1021/jm060051s
10143882 14350 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 511 8 1 4 5.4 CC(C)CC1NC(=O)C2(CCN(Cc3ccc(Oc4ccccc4)cc3)CC2)N(Cc2ccccc2)C1=O 10.1016/j.bmc.2010.05.057
CHEMBL1171289 14350 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 511 8 1 4 5.4 CC(C)CC1NC(=O)C2(CCN(Cc3ccc(Oc4ccccc4)cc3)CC2)N(Cc2ccccc2)C1=O 10.1016/j.bmc.2010.05.057
CHEMBL1200078 14350 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 511 8 1 4 5.4 CC(C)CC1NC(=O)C2(CCN(Cc3ccc(Oc4ccccc4)cc3)CC2)N(Cc2ccccc2)C1=O 10.1016/j.bmc.2010.05.057
505866 28432 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 475 7 0 4 4.7 CCCN(c1ccccn1)C1CCN(C[C@H]2CN(C(=O)N3CCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00988-5
CHEMBL137524 28432 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 475 7 0 4 4.7 CCCN(c1ccccn1)C1CCN(C[C@H]2CN(C(=O)N3CCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00988-5
505865 29287 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 516 8 0 4 6.0 CCCN(c1ccccn1)C1CCN(C[C@H]2CN(C(=O)c3ccccc3Cl)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00988-5
CHEMBL138282 29287 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 516 8 0 4 6.0 CCCN(c1ccccn1)C1CCN(C[C@H]2CN(C(=O)c3ccccc3Cl)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00988-5
505867 29710 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 460 8 0 4 4.8 CCCN(c1ccccn1)C1CCN(C[C@H]2CN(C(=O)C3CCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00988-5
CHEMBL138645 29710 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 460 8 0 4 4.8 CCCN(c1ccccn1)C1CCN(C[C@H]2CN(C(=O)C3CCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00988-5
72711280 92744 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 533 8 1 6 4.3 Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccccn2)CC1 10.1021/jm401101p
CHEMBL2435900 92744 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 533 8 1 6 4.3 Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccccn2)CC1 10.1021/jm401101p
10205915 12809 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 441 11 1 3 4.4 CCCN1C(=O)[C@@H](CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 10.1021/jm060051s
CHEMBL1188208 12809 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 441 11 1 3 4.4 CCCN1C(=O)[C@@H](CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 10.1021/jm060051s
CHEMBL535616 12809 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 441 11 1 3 4.4 CCCN1C(=O)[C@@H](CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 10.1021/jm060051s
10116073 14409 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 469 7 1 4 4.3 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(C(=O)OCc1ccccc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1173708 14409 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 469 7 1 4 4.3 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(C(=O)OCc1ccccc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1200300 14409 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 469 7 1 4 4.3 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(C(=O)OCc1ccccc1)CC2 10.1016/j.bmc.2010.05.057
23577448 66648 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 563 9 3 6 4.2 CCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813448 66648 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 563 9 3 6 4.2 CCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1852753 66648 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 563 9 3 6 4.2 CCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
3001322 443 None 22 Rabbit Functional pIC50 = 4.5 4.5 -75857 4
Antagonist activity at rabbit CCR5 assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity at rabbit CCR5 assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.bmc.2011.05.022
805 443 None 22 Rabbit Functional pIC50 = 4.5 4.5 -75857 4
Antagonist activity at rabbit CCR5 assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity at rabbit CCR5 assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.bmc.2011.05.022
CHEMBL1255794 443 None 22 Rabbit Functional pIC50 = 4.5 4.5 -75857 4
Antagonist activity at rabbit CCR5 assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity at rabbit CCR5 assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.bmc.2011.05.022
DB06497 443 None 22 Rabbit Functional pIC50 = 4.5 4.5 -75857 4
Antagonist activity at rabbit CCR5 assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity at rabbit CCR5 assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.bmc.2011.05.022
122185615 122977 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 526 6 2 2 6.0 Cc1c(CNC(=O)c2ccc(C(C)(C)C)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(C(C)(C)C)cc1)CCC2 10.1016/j.bmcl.2015.06.029
CHEMBL3604299 122977 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 526 6 2 2 6.0 Cc1c(CNC(=O)c2ccc(C(C)(C)C)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(C(C)(C)C)cc1)CCC2 10.1016/j.bmcl.2015.06.029
CHEMBL3606049 122977 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 526 6 2 2 6.0 Cc1c(CNC(=O)c2ccc(C(C)(C)C)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(C(C)(C)C)cc1)CCC2 10.1016/j.bmcl.2015.06.029
3008925 100968 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 492 5 1 3 6.5 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2cccc3[nH]ccc23)CC1 10.1021/jm031046g
CHEMBL293900 100968 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 492 5 1 3 6.5 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2cccc3[nH]ccc23)CC1 10.1021/jm031046g
3008931 205104 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 559 6 0 5 7.1 Cc1nc(-c2ccccc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL61374 205104 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 559 6 0 5 7.1 Cc1nc(-c2ccccc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
71451541 81811 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 569 10 1 6 4.9 Cc1ccncc1CN(C(=O)CC1CCOCC1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 10.1021/ml2002604
CHEMBL2164214 81811 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 569 10 1 6 4.9 Cc1ccncc1CN(C(=O)CC1CCOCC1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1 10.1021/ml2002604
168286382 191842 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 570 10 2 8 4.4 CNS(=O)(=O)c1cccc(C(=O)N[C@@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)c2cccs2)c1 10.1021/acs.jmedchem.2c01383
CHEMBL5197247 191842 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 570 10 2 8 4.4 CNS(=O)(=O)c1cccc(C(=O)N[C@@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)c2cccs2)c1 10.1021/acs.jmedchem.2c01383
46225513 203866 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 505 7 1 6 2.3 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C(C)(C)CO)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL604680 203866 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 505 7 1 6 2.3 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C(C)(C)CO)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
52943425 19074 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 812 13 3 6 6.2 C=CCN(C(=O)NCc1ccc(C(N)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288915 19074 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 812 13 3 6 6.2 C=CCN(C(=O)NCc1ccc(C(N)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
49864967 15786 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 620 11 1 8 4.7 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2cccc(OC)c2)CC1 10.1016/j.bmcl.2010.05.046
CHEMBL1222765 15786 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 620 11 1 8 4.7 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2cccc(OC)c2)CC1 10.1016/j.bmcl.2010.05.046
118727177 117445 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 494 8 0 4 4.0 CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)c2ccccc2)CC1 10.1016/j.bmc.2014.12.052
CHEMBL3397988 117445 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 494 8 0 4 4.0 CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)c2ccccc2)CC1 10.1016/j.bmc.2014.12.052
72711049 92738 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 557 8 1 6 4.8 Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2cccc(C#N)c2)CC1 10.1021/jm401101p
CHEMBL2435894 92738 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 557 8 1 6 4.8 Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2cccc(C#N)c2)CC1 10.1021/jm401101p
49798920 14347 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 423 6 1 5 2.4 COCC1NC(=O)C2(CCN(Cc3ccc(Oc4ccccc4)cc3)CC2)N(C)C1=O 10.1016/j.bmc.2010.05.057
CHEMBL1171103 14347 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 423 6 1 5 2.4 COCC1NC(=O)C2(CCN(Cc3ccc(Oc4ccccc4)cc3)CC2)N(C)C1=O 10.1016/j.bmc.2010.05.057
CHEMBL1200062 14347 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 423 6 1 5 2.4 COCC1NC(=O)C2(CCN(Cc3ccc(Oc4ccccc4)cc3)CC2)N(C)C1=O 10.1016/j.bmc.2010.05.057
57331277 104635 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 584 10 0 4 5.2 CCN(Cc1ccc(F)cc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
CHEMBL3104678 104635 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 584 10 0 4 5.2 CCN(Cc1ccc(F)cc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
10204589 13048 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 419 6 1 3 3.6 CC(C)C[C@@H]1NC(=O)C2(CCN(Cc3ccccc3)CC2)N(Cc2ccccc2)C1=O 10.1021/jm060051s
CHEMBL1189988 13048 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 419 6 1 3 3.6 CC(C)C[C@@H]1NC(=O)C2(CCN(Cc3ccccc3)CC2)N(Cc2ccccc2)C1=O 10.1021/jm060051s
CHEMBL539854 13048 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 419 6 1 3 3.6 CC(C)C[C@@H]1NC(=O)C2(CCN(Cc3ccccc3)CC2)N(Cc2ccccc2)C1=O 10.1021/jm060051s
56681915 66438 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 591 10 3 6 5.0 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813440 66438 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 591 10 3 6 5.0 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851889 66438 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 591 10 3 6 5.0 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
72714317 92731 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 546 8 1 5 5.2 Cc1ccccc1C1CN(C2CCCCC2)C(=O)N1C1CCN(C(C)CCNC(=O)c2c(C)ncnc2C)CC1 10.1021/jm401101p
CHEMBL2435887 92731 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 546 8 1 5 5.2 Cc1ccccc1C1CN(C2CCCCC2)C(=O)N1C1CCN(C(C)CCNC(=O)c2c(C)ncnc2C)CC1 10.1021/jm401101p
122668167 165969 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 523 9 1 6 5.9 Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)Cc2ccc(F)cc2)s1 10.1021/acs.jmedchem.8b01077
CHEMBL4249259 165969 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 523 9 1 6 5.9 Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)Cc2ccc(F)cc2)s1 10.1021/acs.jmedchem.8b01077
16659334 14009 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 493 9 2 5 4.0 CCCCN1C(=O)[C@@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
CHEMBL1197042 14009 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 493 9 2 5 4.0 CCCCN1C(=O)[C@@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
CHEMBL559168 14009 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 493 9 2 5 4.0 CCCCN1C(=O)[C@@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
21064295 14334 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 574 10 2 5 5.3 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1170875 14334 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 574 10 2 5 5.3 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1200016 14334 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 574 10 2 5 5.3 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2010.05.057
505870 27635 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 500 8 0 4 5.6 O=C(C1CCCCC1)N1C[C@H](CN2CCC(N(CC3CC3)c3ccccn3)CC2)[C@@H](c2ccccc2)C1 10.1016/s0960-894x(02)00988-5
CHEMBL136977 27635 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 500 8 0 4 5.6 O=C(C1CCCCC1)N1C[C@H](CN2CCC(N(CC3CC3)c3ccccn3)CC2)[C@@H](c2ccccc2)C1 10.1016/s0960-894x(02)00988-5
505880 27730 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 519 10 1 6 4.9 CCCN(c1ncccn1)C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00988-5
CHEMBL137038 27730 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 519 10 1 6 4.9 CCCN(c1ncccn1)C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00988-5
505879 28655 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 518 10 1 5 5.5 CCCN(c1cccnc1)C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00988-5
CHEMBL137728 28655 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 518 10 1 5 5.5 CCCN(c1cccnc1)C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00988-5
505881 29459 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 537 10 1 6 5.0 CCCN(c1ncccn1)C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 10.1016/s0960-894x(02)00988-5
CHEMBL138437 29459 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 537 10 1 6 5.0 CCCN(c1ncccn1)C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 10.1016/s0960-894x(02)00988-5
44357063 119208 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 523 11 1 6 4.7 CCCN(c1ccncn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/s0960-894x(02)00988-5
CHEMBL342842 119208 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 523 11 1 6 4.7 CCCN(c1ccncn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/s0960-894x(02)00988-5
44357079 119405 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 541 11 1 6 4.8 CCCN(c1ncc(F)cn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/s0960-894x(02)00988-5
CHEMBL344261 119405 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 541 11 1 6 4.8 CCCN(c1ncc(F)cn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/s0960-894x(02)00988-5
118727185 117453 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 604 9 0 4 6.3 Cc1ccc(N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)C(=O)C2CCN(C(=O)c3ccccc3)CC2)cc1Cl 10.1016/j.bmc.2014.12.052
CHEMBL3397996 117453 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 604 9 0 4 6.3 Cc1ccc(N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)C(=O)C2CCN(C(=O)c3ccccc3)CC2)cc1Cl 10.1016/j.bmc.2014.12.052
10118535 14326 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 477 8 1 4 4.8 CC(C)CC1NC(=O)C2(CCN(Cc3ccc(Oc4ccccc4)cc3)CC2)N(CC(C)C)C1=O 10.1016/j.bmc.2010.05.057
CHEMBL1170471 14326 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 477 8 1 4 4.8 CC(C)CC1NC(=O)C2(CCN(Cc3ccc(Oc4ccccc4)cc3)CC2)N(CC(C)C)C1=O 10.1016/j.bmc.2010.05.057
CHEMBL1199972 14326 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 477 8 1 4 4.8 CC(C)CC1NC(=O)C2(CCN(Cc3ccc(Oc4ccccc4)cc3)CC2)N(CC(C)C)C1=O 10.1016/j.bmc.2010.05.057
23577409 66439 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 563 10 3 6 4.2 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813439 66439 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 563 10 3 6 4.2 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851891 66439 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 563 10 3 6 4.2 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
23577328 66455 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 592 10 3 7 3.1 CNC(=O)c1ccc(Oc2ccc(CN3CCC4(CC3)C(=O)N[C@H]([C@H](O)C3CCCCC3)C(=O)N4CCOC)cc2)cc1 10.1016/j.bmc.2011.05.022
CHEMBL1813454 66455 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 592 10 3 7 3.1 CNC(=O)c1ccc(Oc2ccc(CN3CCC4(CC3)C(=O)N[C@H]([C@H](O)C3CCCCC3)C(=O)N4CCOC)cc2)cc1 10.1016/j.bmc.2011.05.022
CHEMBL1851967 66455 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 592 10 3 7 3.1 CNC(=O)c1ccc(Oc2ccc(CN3CCC4(CC3)C(=O)N[C@H]([C@H](O)C3CCCCC3)C(=O)N4CCOC)cc2)cc1 10.1016/j.bmc.2011.05.022
46225345 202495 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 549 6 0 5 4.6 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)CC(C)(C)C)CC3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL595559 202495 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 549 6 0 5 4.6 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)CC(C)(C)C)CC3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
11192476 69220 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 578 9 1 4 7.1 CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2ccccc2)c2ccc(C(F)(F)F)cc2)CC1 10.1016/j.bmcl.2011.09.133
CHEMBL1926872 69220 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 578 9 1 4 7.1 CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2ccccc2)c2ccc(C(F)(F)F)cc2)CC1 10.1016/j.bmcl.2011.09.133
52947090 19068 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 773 11 2 5 7.6 C=CCN(C(=O)Nc1ccc(F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288909 19068 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 773 11 2 5 7.6 C=CCN(C(=O)Nc1ccc(F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
3001322 443 None 22 Human Functional pIC50 = 7.5 7.5 -123 4
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.bmcl.2010.12.109
805 443 None 22 Human Functional pIC50 = 7.5 7.5 -123 4
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.bmcl.2010.12.109
CHEMBL1255794 443 None 22 Human Functional pIC50 = 7.5 7.5 -123 4
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.bmcl.2010.12.109
DB06497 443 None 22 Human Functional pIC50 = 7.5 7.5 -123 4
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.bmcl.2010.12.109
11597 674 None 6 Human Functional pIC50 = 7.5 7.5 -11 2
Antagonist activity at CCR5 in human whole blood assessed as inhibition of MIP-1beta-induced CD11b upregulationAntagonist activity at CCR5 in human whole blood assessed as inhibition of MIP-1beta-induced CD11b upregulation
ChEMBL 506 5 3 6 3.5 CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C 10.1021/acsmedchemlett.1c00373
23725180 674 None 6 Human Functional pIC50 = 7.5 7.5 -11 2
Antagonist activity at CCR5 in human whole blood assessed as inhibition of MIP-1beta-induced CD11b upregulationAntagonist activity at CCR5 in human whole blood assessed as inhibition of MIP-1beta-induced CD11b upregulation
ChEMBL 506 5 3 6 3.5 CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C 10.1021/acsmedchemlett.1c00373
CHEMBL4781426 674 None 6 Human Functional pIC50 = 7.5 7.5 -11 2
Antagonist activity at CCR5 in human whole blood assessed as inhibition of MIP-1beta-induced CD11b upregulationAntagonist activity at CCR5 in human whole blood assessed as inhibition of MIP-1beta-induced CD11b upregulation
ChEMBL 506 5 3 6 3.5 CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C 10.1021/acsmedchemlett.1c00373
23577388 66399 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 611 10 2 7 4.3 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(S(C)(=O)=O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813434 66399 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 611 10 2 7 4.3 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(S(C)(=O)=O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851692 66399 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 611 10 2 7 4.3 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(S(C)(=O)=O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
52943424 19072 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 833 12 2 7 6.8 C=CCN(C(=O)Nc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288913 19072 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 833 12 2 7 6.8 C=CCN(C(=O)Nc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
21926130 14389 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 519 8 1 5 4.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1c(C)nn(-c3ccccc3)c1C)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1200253 14389 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 519 8 1 5 4.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1c(C)nn(-c3ccccc3)c1C)CC2 10.1016/j.bmc.2010.05.057
CHEMBL3216711 14389 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 519 8 1 5 4.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1c(C)nn(-c3ccccc3)c1C)CC2 10.1016/j.bmc.2010.05.057
57331276 104640 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 556 9 1 4 4.5 CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCc3ccc(F)cc3)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
CHEMBL3104683 104640 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 556 9 1 4 4.5 CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCc3ccc(F)cc3)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
3008905 201174 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 537 6 0 5 5.0 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccc(C#N)cc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL58248 201174 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 537 6 0 5 5.0 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccc(C#N)cc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
23577362 66397 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 612 10 3 7 3.5 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(S(N)(=O)=O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813433 66397 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 612 10 3 7 3.5 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(S(N)(=O)=O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851690 66397 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 612 10 3 7 3.5 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(S(N)(=O)=O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
56678578 66424 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 618 12 3 6 5.0 CCCCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813451 66424 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 618 12 3 6 5.0 CCCCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851823 66424 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 618 12 3 6 5.0 CCCCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
46225429 202541 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 527 5 0 5 4.2 Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C(C)(C)C)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL595902 202541 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 527 5 0 5 4.2 Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C(C)(C)C)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
46225348 202628 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 515 6 0 5 3.8 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C4CCCC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL596519 202628 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 515 6 0 5 3.8 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C4CCCC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
46225347 202500 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 559 5 0 5 4.7 Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)(C)C)CC3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL595584 202500 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 559 5 0 5 4.7 Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)(C)C)CC3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
44356876 28050 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 554 8 0 4 6.4 C=CCN(c1ccc(C(F)(F)F)cn1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00988-5
CHEMBL137272 28050 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 554 8 0 4 6.4 C=CCN(c1ccc(C(F)(F)F)cn1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00988-5
44129650 10821 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 623 10 1 7 4.2 C=CCN(C(=O)OCc1ccc(S(C)(=O)=O)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172040 10821 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 623 10 1 7 4.2 C=CCN(C(=O)OCc1ccc(S(C)(=O)=O)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
49798084 10812 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 544 9 2 4 4.4 C=CCN(C(=O)NCc1ccccc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1171966 10812 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 544 9 2 4 4.4 C=CCN(C(=O)NCc1ccccc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
56676455 66472 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 456 18 0 0 9.7 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.bmcl.2012.05.127
CHEMBL1817916 66472 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 456 18 0 0 9.7 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.bmcl.2012.05.127
CHEMBL1852060 66472 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 456 18 0 0 9.7 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.bmcl.2012.05.127
CHEMBL2057819 66472 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 456 18 0 0 9.7 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.bmcl.2012.05.127
56676455 66472 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 456 18 0 0 9.7 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.bmcl.2011.07.058
CHEMBL1817916 66472 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 456 18 0 0 9.7 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.bmcl.2011.07.058
CHEMBL1852060 66472 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 456 18 0 0 9.7 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.bmcl.2011.07.058
CHEMBL2057819 66472 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 456 18 0 0 9.7 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.bmcl.2011.07.058
46225530 202123 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 550 6 0 4 4.7 Cc1ccnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL592997 202123 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 550 6 0 4 4.7 Cc1ccnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
46225527 202150 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 571 6 0 6 3.3 Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCOC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL593184 202150 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 571 6 0 6 3.3 Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCOC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
49864970 15789 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 630 9 2 4 5.5 C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccc(F)cc2)CC1 10.1016/j.bmcl.2010.05.046
CHEMBL1222768 15789 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 630 9 2 4 5.5 C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccc(F)cc2)CC1 10.1016/j.bmcl.2010.05.046
11947758 60140 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assayAntagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL1668021 60140 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assayAntagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL1739499 60140 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assayAntagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
23577382 66459 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 590 10 3 6 4.2 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813432 66459 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 590 10 3 6 4.2 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851977 66459 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 590 10 3 6 4.2 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
122185619 122979 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 570 6 2 2 4.9 Cc1c(CNC(=O)c2ccc(Br)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(Br)cc1)CCC2 10.1016/j.bmcl.2015.06.029
CHEMBL3604301 122979 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 570 6 2 2 4.9 Cc1c(CNC(=O)c2ccc(Br)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(Br)cc1)CCC2 10.1016/j.bmcl.2015.06.029
CHEMBL3606051 122979 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 570 6 2 2 4.9 Cc1c(CNC(=O)c2ccc(Br)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(Br)cc1)CCC2 10.1016/j.bmcl.2015.06.029
57392302 69228 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 618 10 1 5 6.8 COc1cccc(CN(c2ccc(Br)cc2)C2CCN(C(C)CCNC(=O)c3c(Cl)cncc3Cl)CC2)c1 10.1016/j.bmcl.2011.09.133
CHEMBL1926882 69228 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 618 10 1 5 6.8 COc1cccc(CN(c2ccc(Br)cc2)C2CCN(C(C)CCNC(=O)c3c(Cl)cncc3Cl)CC2)c1 10.1016/j.bmcl.2011.09.133
73355553 92845 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 417 6 2 6 3.7 COc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.ejmech.2013.09.004
CHEMBL2436816 92845 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 417 6 2 6 3.7 COc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.ejmech.2013.09.004
56681917 66457 None 0 Human Functional pIC50 = 5.4 5.4 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 604 11 3 6 4.6 CCCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813450 66457 None 0 Human Functional pIC50 = 5.4 5.4 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 604 11 3 6 4.6 CCCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851972 66457 None 0 Human Functional pIC50 = 5.4 5.4 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 604 11 3 6 4.6 CCCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
23577360 66394 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 576 10 3 6 4.0 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(N)=O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813271 66394 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 576 10 3 6 4.0 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(N)=O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851675 66394 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 576 10 3 6 4.0 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(N)=O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
162659856 181344 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysisAntagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysis
ChEMBL 914 27 5 11 5.6 CNC(=O)COCC(=O)NCCCCCCCCCNC(=O)COCC(=O)Nc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)cc1 10.1016/j.bmc.2016.09.059
CHEMBL4761614 181344 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysisAntagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysis
ChEMBL 914 27 5 11 5.6 CNC(=O)COCC(=O)NCCCCCCCCCNC(=O)COCC(=O)Nc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)cc1 10.1016/j.bmc.2016.09.059
162658125 181202 None 0 Human Functional pIC50 = 5.4 5.4 -100 3
Antagonist activity at human CCR5 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting methodAntagonist activity at human CCR5 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting method
ChEMBL 471 6 2 4 5.9 O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 10.1021/acs.jmedchem.0c01137
CHEMBL4760108 181202 None 0 Human Functional pIC50 = 5.4 5.4 -100 3
Antagonist activity at human CCR5 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting methodAntagonist activity at human CCR5 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting method
ChEMBL 471 6 2 4 5.9 O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 10.1021/acs.jmedchem.0c01137
162666730 182380 None 1 Human Functional pIC50 = 5.4 5.4 -562 3
Antagonist activity at human CCR5 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting methodAntagonist activity at human CCR5 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting method
ChEMBL 589 9 2 6 6.5 N#CSCCNC(=O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 10.1021/acs.jmedchem.0c01137
CHEMBL4783861 182380 None 1 Human Functional pIC50 = 5.4 5.4 -562 3
Antagonist activity at human CCR5 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting methodAntagonist activity at human CCR5 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting method
ChEMBL 589 9 2 6 6.5 N#CSCCNC(=O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 10.1021/acs.jmedchem.0c01137
145984591 166016 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 587 8 1 6 7.0 Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C(C)C)nnc2C(F)(F)F)C3)NC(=O)C2CCC(F)(F)CC2)s1 10.1021/acs.jmedchem.8b01077
CHEMBL4250366 166016 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 587 8 1 6 7.0 Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C(C)C)nnc2C(F)(F)F)C3)NC(=O)C2CCC(F)(F)CC2)s1 10.1021/acs.jmedchem.8b01077
49798158 10889 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 607 10 1 6 3.6 C=CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172623 10889 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 607 10 1 6 3.6 C=CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
11585625 77112 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 648 10 1 6 4.0 CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(NS(=O)(=O)c3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
CHEMBL207447 77112 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 648 10 1 6 4.0 CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(NS(=O)(=O)c3ccc(F)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
72712598 92692 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 591 5 0 4 6.6 Cc1cc(Cl)nc(C)c1C(=O)N1CCC(C)(N2CCC(N3C(=O)N(C4CCCCC4)C[C@H]3c3ccccc3)CC2)CC1 10.1021/jm401101p
CHEMBL2435848 92692 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 591 5 0 4 6.6 Cc1cc(Cl)nc(C)c1C(=O)N1CCC(C)(N2CCC(N3C(=O)N(C4CCCCC4)C[C@H]3c3ccccc3)CC2)CC1 10.1021/jm401101p
50992246 58488 None 2 Human Functional pIC50 = 8.4 8.4 -1 5
Antagonist activity at human CCR5 receptor by chemotaxis assayAntagonist activity at human CCR5 receptor by chemotaxis assay
ChEMBL 498 6 1 6 3.3 CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(C)C)C1 10.1016/j.bmcl.2011.01.015
CHEMBL1683074 58488 None 2 Human Functional pIC50 = 8.4 8.4 -1 5
Antagonist activity at human CCR5 receptor by chemotaxis assayAntagonist activity at human CCR5 receptor by chemotaxis assay
ChEMBL 498 6 1 6 3.3 CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(C)C)C1 10.1016/j.bmcl.2011.01.015
168276745 190707 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 503 8 1 6 6.0 Cc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCCC1)c1ccsc1Cl 10.1021/acs.jmedchem.2c01383
CHEMBL5180628 190707 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 503 8 1 6 6.0 Cc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCCC1)c1ccsc1Cl 10.1021/acs.jmedchem.2c01383
72714076 92727 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 532 8 1 5 4.9 Cc1ncnc(C)c1C(=O)NCC[C@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
CHEMBL2435883 92727 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 532 8 1 5 4.9 Cc1ncnc(C)c1C(=O)NCC[C@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
52943390 19064 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 795 12 1 7 7.4 C=CCN(C(=O)OCc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288877 19064 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 795 12 1 7 7.4 C=CCN(C(=O)OCc1ccc(C#N)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
52943389 19063 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 848 13 1 8 7.0 C=CCN(C(=O)OCc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288876 19063 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 848 13 1 8 7.0 C=CCN(C(=O)OCc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
145986145 165584 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 573 8 1 6 6.7 CC(C)c1nnc(C(F)(F)F)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cccs1 10.1021/acs.jmedchem.8b01077
CHEMBL4240242 165584 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 573 8 1 6 6.7 CC(C)c1nnc(C(F)(F)F)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cccs1 10.1021/acs.jmedchem.8b01077
72711277 92741 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 560 8 1 5 5.5 Cc1cc(C)cc(C2CN(C3CCCCC3)C(=O)N2C2CCN(C(C)CCNC(=O)c3c(C)ncnc3C)CC2)c1 10.1021/jm401101p
CHEMBL2435897 92741 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 560 8 1 5 5.5 Cc1cc(C)cc(C2CN(C3CCCCC3)C(=O)N2C2CCN(C(C)CCNC(=O)c3c(C)ncnc3C)CC2)c1 10.1021/jm401101p
44511861 69241 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 549 10 1 6 5.7 COc1ccc(N(Cc2cnccc2C)C2CCN([C@@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
CHEMBL1926895 69241 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 549 10 1 6 5.7 COc1ccc(N(Cc2cnccc2C)C2CCN([C@@H](C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
52944586 19060 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 838 12 1 6 8.6 C=CCN(C(=O)OCc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288873 19060 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 838 12 1 6 8.6 C=CCN(C(=O)OCc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
21064299 14335 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 610 11 2 6 5.3 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(NS(C)(=O)=O)cc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1170876 14335 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 610 11 2 6 5.3 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(NS(C)(=O)=O)cc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1200017 14335 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 610 11 2 6 5.3 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(NS(C)(=O)=O)cc3)cc1)CC2 10.1016/j.bmc.2010.05.057
168275071 190559 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 534 9 2 7 5.5 CC(=O)Nc1cccc(C(=O)N[C@@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)c2cccs2)c1 10.1021/acs.jmedchem.2c01383
CHEMBL5178495 190559 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 534 9 2 7 5.5 CC(=O)Nc1cccc(C(=O)N[C@@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)c2cccs2)c1 10.1021/acs.jmedchem.2c01383
70685193 73149 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at CCR5 (unknown origin)Antagonist activity at CCR5 (unknown origin)
ChEMBL 410 6 0 4 5.6 Cc1nc2cnccc2n1C1CCN(CCC(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.8b00180
CHEMBL2011438 73149 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at CCR5 (unknown origin)Antagonist activity at CCR5 (unknown origin)
ChEMBL 410 6 0 4 5.6 Cc1nc2cnccc2n1C1CCN(CCC(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.8b00180
9956238 60218 None 0 Human Functional pIC50 = 6.4 6.4 -3 4
Antagonist activity at CCR5 in human PBMC cells assessed as inhibition of CCL4-induced chemotaxis after 2 hrs trans-well migration assayAntagonist activity at CCR5 in human PBMC cells assessed as inhibition of CCL4-induced chemotaxis after 2 hrs trans-well migration assay
ChEMBL 467 8 2 8 3.0 Cc1nn(C)c2nc(N(C)CCN(C)C)c(C(=O)NC(=O)Nc3cccc(OC(C)C)c3)cc12 10.1021/jm1012903
CHEMBL1688889 60218 None 0 Human Functional pIC50 = 6.4 6.4 -3 4
Antagonist activity at CCR5 in human PBMC cells assessed as inhibition of CCL4-induced chemotaxis after 2 hrs trans-well migration assayAntagonist activity at CCR5 in human PBMC cells assessed as inhibition of CCL4-induced chemotaxis after 2 hrs trans-well migration assay
ChEMBL 467 8 2 8 3.0 Cc1nn(C)c2nc(N(C)CCN(C)C)c(C(=O)NC(=O)Nc3cccc(OC(C)C)c3)cc12 10.1021/jm1012903
CHEMBL1739922 60218 None 0 Human Functional pIC50 = 6.4 6.4 -3 4
Antagonist activity at CCR5 in human PBMC cells assessed as inhibition of CCL4-induced chemotaxis after 2 hrs trans-well migration assayAntagonist activity at CCR5 in human PBMC cells assessed as inhibition of CCL4-induced chemotaxis after 2 hrs trans-well migration assay
ChEMBL 467 8 2 8 3.0 Cc1nn(C)c2nc(N(C)CCN(C)C)c(C(=O)NC(=O)Nc3cccc(OC(C)C)c3)cc12 10.1021/jm1012903
10208679 12846 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 493 9 2 5 4.0 CCCCN1C(=O)[C@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
CHEMBL1188565 12846 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 493 9 2 5 4.0 CCCCN1C(=O)[C@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
CHEMBL536751 12846 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 493 9 2 5 4.0 CCCCN1C(=O)[C@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
3008921 168335 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 459 5 0 3 6.3 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)C2CCCCC2)CC1 10.1021/jm031046g
CHEMBL433635 168335 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 459 5 0 3 6.3 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)C2CCCCC2)CC1 10.1021/jm031046g
52940989 19062 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 828 13 1 8 7.3 C=CCN(C(=O)OCc1ccc(C(=O)OC)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288875 19062 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 828 13 1 8 7.3 C=CCN(C(=O)OCc1ccc(C(=O)OC)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
3008933 204088 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 531 6 0 4 6.5 Cc1cc(C)c(S(=O)(=O)N2CCC(C)(N3CCC(N(c4ccccc4)c4ccccc4)CC3)CC2)c(C)c1 10.1021/jm031046g
CHEMBL60589 204088 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 531 6 0 4 6.5 Cc1cc(C)c(S(=O)(=O)N2CCC(C)(N3CCC(N(c4ccccc4)c4ccccc4)CC3)CC2)c(C)c1 10.1021/jm031046g
90656335 111134 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 475 8 2 7 3.5 CC(C)Oc1ccc(N2CCN(Cc3ccc(C(=O)O)cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.bmcl.2014.03.073
CHEMBL3263031 111134 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 475 8 2 7 3.5 CC(C)Oc1ccc(N2CCN(Cc3ccc(C(=O)O)cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.bmcl.2014.03.073
52944587 19067 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 837 12 2 5 8.1 C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288880 19067 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 837 12 2 5 8.1 C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
49799711 14412 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 533 9 2 5 5.6 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(O)cc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1173712 14412 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 533 9 2 5 5.6 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(O)cc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1200303 14412 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 533 9 2 5 5.6 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(O)cc3)cc1)CC2 10.1016/j.bmc.2010.05.057
46226128 14119 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 547 10 2 5 5.7 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(O)cc3)c1)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL1198003 14119 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 547 10 2 5 5.7 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(O)cc3)c1)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL592944 14119 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 547 10 2 5 5.7 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(O)cc3)c1)CC2 10.1016/j.bmcl.2009.11.018
3008922 201164 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 513 7 0 5 6.0 COc1cccc(OC)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL58176 201164 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 513 7 0 5 6.0 COc1cccc(OC)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
52942223 19081 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 810 14 1 6 7.1 C=CCN(C(=O)CCc1ccc(OC(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288922 19081 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 810 14 1 6 7.1 C=CCN(C(=O)CCc1ccc(OC(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
3008912 203529 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 458 4 1 4 5.4 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc4ccn(C)c4c3)CC2)CC1 10.1021/jm031046g
CHEMBL60279 203529 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 458 4 1 4 5.4 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc4ccn(C)c4c3)CC2)CC1 10.1021/jm031046g
72712371 92715 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 494 6 0 3 6.5 O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(-c3ccncc3)cc2)CC1 10.1021/jm401101p
CHEMBL2435871 92715 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 494 6 0 3 6.5 O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc(-c3ccncc3)cc2)CC1 10.1021/jm401101p
10278617 95235 None 3 Human Functional pIC50 = 7.4 7.4 1 2
Antagonist activity at human CCR5 expressed in CHO cells assessed as MIP-1-alpha-induced Ca2+ mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as MIP-1-alpha-induced Ca2+ mobilization
ChEMBL 499 5 0 5 4.6 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1 10.1016/j.bmcl.2008.01.108
CHEMBL255858 95235 None 3 Human Functional pIC50 = 7.4 7.4 1 2
Antagonist activity at human CCR5 expressed in CHO cells assessed as MIP-1-alpha-induced Ca2+ mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as MIP-1-alpha-induced Ca2+ mobilization
ChEMBL 499 5 0 5 4.6 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1 10.1016/j.bmcl.2008.01.108
72712372 92716 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 499 6 0 6 4.7 Cn1nnc(-c2ccc(CN3CCC(N4C(=O)N(C5CCCCC5)C[C@H]4c4ccccc4)CC3)cc2)n1 10.1021/jm401101p
CHEMBL2435872 92716 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 499 6 0 6 4.7 Cn1nnc(-c2ccc(CN3CCC(N4C(=O)N(C5CCCCC5)C[C@H]4c4ccccc4)CC3)cc2)n1 10.1021/jm401101p
73355554 92852 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 431 7 2 6 4.1 CCOc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.ejmech.2013.09.004
CHEMBL2436824 92852 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 431 7 2 6 4.1 CCOc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.ejmech.2013.09.004
53324598 60132 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL1668020 60132 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL1739382 60132 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
5275761 77147 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 609 10 1 5 5.0 CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(C(=O)O)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
CHEMBL207633 77147 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 609 10 1 5 5.0 CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(C(=O)O)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
53324598 60132 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1668020 60132 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1739382 60132 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
6320546 60143 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assayAntagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL1668022 60143 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assayAntagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL1739500 60143 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assayAntagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
168295761 192570 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 497 9 1 10 3.2 Cc1ccc([C@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)Cn2cnnn2)s1 10.1021/acs.jmedchem.2c01383
CHEMBL5208613 192570 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 497 9 1 10 3.2 Cc1ccc([C@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)Cn2cnnn2)s1 10.1021/acs.jmedchem.2c01383
21064338 14405 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 506 8 1 5 5.1 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1nc(-c3ccccc3)oc1C)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1173645 14405 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 506 8 1 5 5.1 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1nc(-c3ccccc3)oc1C)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1200293 14405 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 506 8 1 5 5.1 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1nc(-c3ccccc3)oc1C)CC2 10.1016/j.bmc.2010.05.057
44356952 119340 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 591 11 1 6 5.7 CCCN(c1nccc(C(F)(F)F)n1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/s0960-894x(02)00988-5
CHEMBL343745 119340 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5
ChEMBL 591 11 1 6 5.7 CCCN(c1nccc(C(F)(F)F)n1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/s0960-894x(02)00988-5
73349498 92820 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 473 8 1 5 6.0 CC(C)Oc1ccc(C2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1ccccc1 10.1016/j.ejmech.2013.09.004
CHEMBL2436712 92820 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 473 8 1 5 6.0 CC(C)Oc1ccc(C2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1ccccc1 10.1016/j.ejmech.2013.09.004
3008919 100819 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 453 5 0 3 6.0 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2ccccc2)CC1 10.1021/jm031046g
CHEMBL292894 100819 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 453 5 0 3 6.0 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2ccccc2)CC1 10.1021/jm031046g
46225514 202281 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 537 7 0 6 3.0 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(S(=O)(=O)C4CCCC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL594208 202281 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 537 7 0 6 3.0 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(S(=O)(=O)C4CCCC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
90656337 111135 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 509 8 1 8 3.2 CC(C)Oc1ccc(N2CCN(Cc3ccc(S(C)(=O)=O)cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.bmcl.2014.03.073
CHEMBL3263033 111135 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 509 8 1 8 3.2 CC(C)Oc1ccc(N2CCN(Cc3ccc(S(C)(=O)=O)cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.bmcl.2014.03.073
90656338 111136 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 445 7 1 6 4.1 Cc1ccc(CN2CCN(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 10.1016/j.bmcl.2014.03.073
CHEMBL3263034 111136 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 445 7 1 6 4.1 Cc1ccc(CN2CCN(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 10.1016/j.bmcl.2014.03.073
52944086 19069 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 787 12 2 5 7.3 C=CCN(C(=O)NCc1ccc(F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288910 19069 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 787 12 2 5 7.3 C=CCN(C(=O)NCc1ccc(F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
46225349 202506 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 539 6 0 5 4.3 Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C4CCCC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL595610 202506 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 539 6 0 5 4.3 Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C4CCCC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
3001322 443 None 22 Human Functional pIC50 = 7.3 7.3 -123 4
Antagonist activity at human CCR5 assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity at human CCR5 assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.bmc.2011.05.022
805 443 None 22 Human Functional pIC50 = 7.3 7.3 -123 4
Antagonist activity at human CCR5 assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity at human CCR5 assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.bmc.2011.05.022
CHEMBL1255794 443 None 22 Human Functional pIC50 = 7.3 7.3 -123 4
Antagonist activity at human CCR5 assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity at human CCR5 assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.bmc.2011.05.022
DB06497 443 None 22 Human Functional pIC50 = 7.3 7.3 -123 4
Antagonist activity at human CCR5 assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity at human CCR5 assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.bmc.2011.05.022
3008910 202088 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 481 5 1 3 6.5 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(-c4ccccc4)cc3)CC2)CC1 10.1021/jm031046g
CHEMBL59285 202088 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 481 5 1 3 6.5 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc(-c4ccccc4)cc3)CC2)CC1 10.1021/jm031046g
53389083 66467 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 438 16 0 0 9.5 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.bmcl.2012.05.127
CHEMBL1817912 66467 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 438 16 0 0 9.5 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.bmcl.2012.05.127
CHEMBL1852020 66467 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 438 16 0 0 9.5 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.bmcl.2012.05.127
CHEMBL2057816 66467 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 438 16 0 0 9.5 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.bmcl.2012.05.127
53389083 66467 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 438 16 0 0 9.5 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.bmcl.2011.07.058
CHEMBL1817912 66467 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 438 16 0 0 9.5 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.bmcl.2011.07.058
CHEMBL1852020 66467 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 438 16 0 0 9.5 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.bmcl.2011.07.058
CHEMBL2057816 66467 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 438 16 0 0 9.5 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCC2 10.1016/j.bmcl.2011.07.058
56661530 66458 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 616 8 3 6 4.0 CNC(=O)c1ccc(Oc2ccc(CN3CCC4(CC3)C(=O)N[C@H]([C@H](O)C3CCCCC3)C(=O)N4CC(F)(F)F)cc2)cc1 10.1016/j.bmc.2011.05.022
CHEMBL1813457 66458 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 616 8 3 6 4.0 CNC(=O)c1ccc(Oc2ccc(CN3CCC4(CC3)C(=O)N[C@H]([C@H](O)C3CCCCC3)C(=O)N4CC(F)(F)F)cc2)cc1 10.1016/j.bmc.2011.05.022
CHEMBL1851975 66458 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 616 8 3 6 4.0 CNC(=O)c1ccc(Oc2ccc(CN3CCC4(CC3)C(=O)N[C@H]([C@H](O)C3CCCCC3)C(=O)N4CC(F)(F)F)cc2)cc1 10.1016/j.bmc.2011.05.022
122185621 122980 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 482 6 2 2 4.7 Cc1c(CNC(=O)c2ccc(Cl)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(Cl)cc1)CCC2 10.1016/j.bmcl.2015.06.029
CHEMBL3604302 122980 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 482 6 2 2 4.7 Cc1c(CNC(=O)c2ccc(Cl)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(Cl)cc1)CCC2 10.1016/j.bmcl.2015.06.029
CHEMBL3606052 122980 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 482 6 2 2 4.7 Cc1c(CNC(=O)c2ccc(Cl)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(Cl)cc1)CCC2 10.1016/j.bmcl.2015.06.029
11947758 60140 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL1668021 60140 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL1739499 60140 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
73346462 92853 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 473 8 2 6 4.5 CCOc1ccc(C2CCN(Cc3ccc(NC(C)=O)cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.ejmech.2013.09.004
CHEMBL2436825 92853 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 473 8 2 6 4.5 CCOc1ccc(C2CCN(Cc3ccc(NC(C)=O)cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.ejmech.2013.09.004
57331308 104637 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 591 10 0 5 5.0 CCN(Cc1ccc(C#N)cc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
CHEMBL3104680 104637 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 591 10 0 5 5.0 CCN(Cc1ccc(C#N)cc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
3008926 204303 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 492 5 1 3 6.5 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2c[nH]c3ccccc23)CC1 10.1021/jm031046g
CHEMBL60711 204303 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 492 5 1 3 6.5 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2c[nH]c3ccccc23)CC1 10.1021/jm031046g
3008937 202556 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 469 5 0 5 5.0 Cc1ncnc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL59602 202556 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 469 5 0 5 5.0 Cc1ncnc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
15942352 81801 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 505 8 1 5 4.6 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)N(C)C)CC1 10.1021/ml2002604
CHEMBL2164204 81801 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
ChEMBL 505 8 1 5 4.6 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@@H](C)N1CCC(N(Cc2ccsc2)C(=O)N(C)C)CC1 10.1021/ml2002604
86294766 110744 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 502 10 1 7 4.7 CCN(CC)c1ccc(CN2CCN(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 10.1016/j.bmcl.2014.03.073
CHEMBL3259855 110744 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 502 10 1 7 4.7 CCN(CC)c1ccc(CN2CCN(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 10.1016/j.bmcl.2014.03.073
23577362 66397 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 612 10 3 7 3.5 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(S(N)(=O)=O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813433 66397 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 612 10 3 7 3.5 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(S(N)(=O)=O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851690 66397 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 612 10 3 7 3.5 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(S(N)(=O)=O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
10230510 66437 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 537 10 3 6 3.7 CCCCN1C(=O)[C@@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813436 66437 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 537 10 3 6 3.7 CCCCN1C(=O)[C@@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851888 66437 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 537 10 3 6 3.7 CCCCN1C(=O)[C@@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
56659272 66492 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 452 16 0 0 9.8 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.bmcl.2011.07.058
CHEMBL1817915 66492 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 452 16 0 0 9.8 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.bmcl.2011.07.058
CHEMBL1852160 66492 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 452 16 0 0 9.8 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.bmcl.2011.07.058
CHEMBL2057817 66492 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 452 16 0 0 9.8 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.bmcl.2011.07.058
56659272 66492 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 452 16 0 0 9.8 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.bmcl.2012.05.127
CHEMBL1817915 66492 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 452 16 0 0 9.8 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.bmcl.2012.05.127
CHEMBL1852160 66492 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 452 16 0 0 9.8 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.bmcl.2012.05.127
CHEMBL2057817 66492 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 452 16 0 0 9.8 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.bmcl.2012.05.127
54581479 60906 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 588 9 1 4 6.8 CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2ccccc2)c2ccc(Br)cc2)CC1 10.1016/j.bmcl.2011.09.133
CHEMBL1762313 60906 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 588 9 1 4 6.8 CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2ccccc2)c2ccc(Br)cc2)CC1 10.1016/j.bmcl.2011.09.133
118727188 117456 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 542 8 0 4 5.0 CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(F)cc3)C[C@H]2C)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
CHEMBL3397999 117456 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 542 8 0 4 5.0 CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(F)cc3)C[C@H]2C)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
44194675 10834 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 651 11 2 6 3.6 C=CCN(C(=O)NCc1ccc(S(=O)(=O)N(C)C)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172053 10834 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 651 11 2 6 3.6 C=CCN(C(=O)NCc1ccc(S(=O)(=O)N(C)C)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
50992574 57217 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 435 6 1 5 3.6 CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C)CC3)C2)c1ccccc1 10.1021/jm100978n
CHEMBL1649916 57217 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 435 6 1 5 3.6 CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CN(C)CC3)C2)c1ccccc1 10.1021/jm100978n
46225528 202122 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 619 6 0 5 5.1 Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL592993 202122 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 619 6 0 5 5.1 Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCC(F)(F)CC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
72714321 92735 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 610 8 1 5 5.6 Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2cccc(Br)c2)CC1 10.1021/jm401101p
CHEMBL2435891 92735 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 610 8 1 5 5.6 Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2cccc(Br)c2)CC1 10.1021/jm401101p
3008902 205137 None 0 Human Functional pIC50 = 8.3 8.3 -1 2
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 512 6 0 4 5.1 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL61536 205137 None 0 Human Functional pIC50 = 8.3 8.3 -1 2
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 512 6 0 4 5.1 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
145985889 165488 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 498 8 1 7 3.7 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CC(=O)N(C)C1)c1cccs1 10.1021/acs.jmedchem.8b01077
CHEMBL4238007 165488 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 498 8 1 7 3.7 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CC(=O)N(C)C1)c1cccs1 10.1021/acs.jmedchem.8b01077
59458213 92748 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 525 8 1 4 5.2 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C(C)C)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
CHEMBL2435904 92748 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 525 8 1 4 5.2 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C(C)C)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
49798131 10873 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 574 10 1 6 4.2 C=CCN(C(=O)Cc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172439 10873 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 574 10 1 6 4.2 C=CCN(C(=O)Cc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
3013575 75797 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Inhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cellsInhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cells
ChEMBL 682 17 1 7 8.4 CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc([S+]([O-])Cc4cncn4CCC)cc2)CCN3CC(C)C)cc1 10.1021/jm0509703
CHEMBL204821 75797 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Inhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cellsInhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cells
ChEMBL 682 17 1 7 8.4 CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc([S+]([O-])Cc4cncn4CCC)cc2)CCN3CC(C)C)cc1 10.1021/jm0509703
168273684 190499 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 553 8 1 6 6.7 Cc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccsc1Cl 10.1021/acs.jmedchem.2c01383
CHEMBL5177519 190499 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 553 8 1 6 6.7 Cc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccsc1Cl 10.1021/acs.jmedchem.2c01383
145984717 165629 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 511 8 1 6 5.8 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C(C)(C)C(F)(F)F)c1cccs1 10.1021/acs.jmedchem.8b01077
CHEMBL4241284 165629 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 511 8 1 6 5.8 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C(C)(C)C(F)(F)F)c1cccs1 10.1021/acs.jmedchem.8b01077
3001322 443 None 22 Human Functional pIC50 = 8.3 8.3 -123 4
Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assayAntagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.bmcl.2010.12.109
805 443 None 22 Human Functional pIC50 = 8.3 8.3 -123 4
Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assayAntagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.bmcl.2010.12.109
CHEMBL1255794 443 None 22 Human Functional pIC50 = 8.3 8.3 -123 4
Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assayAntagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.bmcl.2010.12.109
DB06497 443 None 22 Human Functional pIC50 = 8.3 8.3 -123 4
Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assayAntagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.bmcl.2010.12.109
51039119 176321 None 34 Human Functional pIC50 = 8.2 8.2 1 3
Antagonist activity at CCR5 in human whole blood assessed as inhibition of MIP-1beta-induced CD11b upregulationAntagonist activity at CCR5 in human whole blood assessed as inhibition of MIP-1beta-induced CD11b upregulation
ChEMBL 484 5 3 8 2.2 CC(=O)N[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1N1CC[C@H](Nc2ncnc3cc(C(C)(C)C)nn23)C1=O 10.1021/acsmedchemlett.1c00373
CHEMBL4594419 176321 None 34 Human Functional pIC50 = 8.2 8.2 1 3
Antagonist activity at CCR5 in human whole blood assessed as inhibition of MIP-1beta-induced CD11b upregulationAntagonist activity at CCR5 in human whole blood assessed as inhibition of MIP-1beta-induced CD11b upregulation
ChEMBL 484 5 3 8 2.2 CC(=O)N[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1N1CC[C@H](Nc2ncnc3cc(C(C)(C)C)nn23)C1=O 10.1021/acsmedchemlett.1c00373
25024699 92691 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 558 5 0 5 5.4 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCC(N3C(=O)N(C4CCCCC4)C[C@H]3c3ccccc3)CC2)CC1 10.1021/jm401101p
CHEMBL2435847 92691 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 558 5 0 5 5.4 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCC(N3C(=O)N(C4CCCCC4)C[C@H]3c3ccccc3)CC2)CC1 10.1021/jm401101p
72711047 92736 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 566 8 1 5 5.5 Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2cccc(Cl)c2)CC1 10.1021/jm401101p
CHEMBL2435892 92736 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 566 8 1 5 5.5 Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2cccc(Cl)c2)CC1 10.1021/jm401101p
3001322 443 None 22 Human Functional pIC50 = 8.2 8.2 -123 4
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced chemotaxisAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced chemotaxis
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.bmc.2011.05.022
805 443 None 22 Human Functional pIC50 = 8.2 8.2 -123 4
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced chemotaxisAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced chemotaxis
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.bmc.2011.05.022
CHEMBL1255794 443 None 22 Human Functional pIC50 = 8.2 8.2 -123 4
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced chemotaxisAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced chemotaxis
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.bmc.2011.05.022
DB06497 443 None 22 Human Functional pIC50 = 8.2 8.2 -123 4
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced chemotaxisAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced chemotaxis
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.bmc.2011.05.022
5275762 77121 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 608 10 1 5 4.4 CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(C(N)=O)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
CHEMBL207485 77121 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 608 10 1 5 4.4 CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccc(C(N)=O)cc3)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
57402798 69221 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 540 10 1 5 6.1 COc1ccc(N(Cc2ccccc2)C2CCN(C(C)CCNC(=O)c3c(Cl)cncc3Cl)CC2)cc1 10.1016/j.bmcl.2011.09.133
CHEMBL1926873 69221 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 540 10 1 5 6.1 COc1ccc(N(Cc2ccccc2)C2CCN(C(C)CCNC(=O)c3c(Cl)cncc3Cl)CC2)cc1 10.1016/j.bmcl.2011.09.133
10208080 13068 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 481 10 1 4 4.7 C=CCOc1ccc(CN2CCC3(CC2)C(=O)NC(CC2CCCCC2)C(=O)N3CCCC)cc1 10.1021/jm060051s
CHEMBL1190106 13068 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 481 10 1 4 4.7 C=CCOc1ccc(CN2CCC3(CC2)C(=O)NC(CC2CCCCC2)C(=O)N3CCCC)cc1 10.1021/jm060051s
CHEMBL540108 13068 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 481 10 1 4 4.7 C=CCOc1ccc(CN2CCC3(CC2)C(=O)NC(CC2CCCCC2)C(=O)N3CCCC)cc1 10.1021/jm060051s
10228759 14352 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 463 9 1 4 4.7 CCCCN1C(=O)C(CCC)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1171291 14352 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 463 9 1 4 4.7 CCCCN1C(=O)C(CCC)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1200080 14352 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 463 9 1 4 4.7 CCCCN1C(=O)C(CCC)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
3500 1526 None 13 Human Functional pIC50 = 7.3 7.3 245 2
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 483 7 1 5 3.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C21CCN(CC2)Cc1ccc2c(c1)OCCO2 10.1016/j.bmcl.2009.11.018
491774 1526 None 13 Human Functional pIC50 = 7.3 7.3 245 2
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 483 7 1 5 3.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C21CCN(CC2)Cc1ccc2c(c1)OCCO2 10.1016/j.bmcl.2009.11.018
CHEMBL1196395 1526 None 13 Human Functional pIC50 = 7.3 7.3 245 2
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 483 7 1 5 3.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C21CCN(CC2)Cc1ccc2c(c1)OCCO2 10.1016/j.bmcl.2009.11.018
10228761 13934 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 463 8 1 4 4.6 CCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1021/jm060051s
CHEMBL1196469 13934 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 463 8 1 4 4.6 CCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1021/jm060051s
CHEMBL557150 13934 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 463 8 1 4 4.6 CCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1021/jm060051s
10228761 13934 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 463 8 1 4 4.6 CCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1196469 13934 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 463 8 1 4 4.6 CCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL557150 13934 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 463 8 1 4 4.6 CCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
56664935 66412 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 535 7 3 6 3.4 CN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813444 66412 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 535 7 3 6 3.4 CN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851773 66412 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 535 7 3 6 3.4 CN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
6320546 60143 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL1668022 60143 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL1739500 60143 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
122668161 165700 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 491 8 1 6 5.8 Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)c2ccccc2)s1 10.1021/acs.jmedchem.8b01077
CHEMBL4242946 165700 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 491 8 1 6 5.8 Cc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)c2ccccc2)s1 10.1021/acs.jmedchem.8b01077
90656341 111192 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 477 8 1 7 4.6 CSc1ccc(CN2CCN(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 10.1016/j.bmcl.2014.03.073
CHEMBL3263320 111192 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 477 8 1 7 4.6 CSc1ccc(CN2CCN(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 10.1016/j.bmcl.2014.03.073
6320546 60143 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1668022 60143 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1739500 60143 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H]([C@@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
3008919 100819 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 453 5 0 3 6.0 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2ccccc2)CC1 10.1021/jm031046g
CHEMBL292894 100819 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 453 5 0 3 6.0 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2ccccc2)CC1 10.1021/jm031046g
73351060 92850 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 487 10 1 6 5.4 CCOc1ccc(C2CCN(Cc3ccc(N(CC)CC)cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.ejmech.2013.09.004
CHEMBL2436822 92850 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 487 10 1 6 5.4 CCOc1ccc(C2CCN(Cc3ccc(N(CC)CC)cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.ejmech.2013.09.004
52941008 19077 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 772 12 1 5 7.1 C=CCN(C(=O)Cc1ccc(F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288918 19077 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 772 12 1 5 7.1 C=CCN(C(=O)Cc1ccc(F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
21926948 14328 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 503 9 1 4 5.5 CCCCN1C(=O)C(CC2CCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1170694 14328 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 503 9 1 4 5.5 CCCCN1C(=O)C(CC2CCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1199991 14328 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 503 9 1 4 5.5 CCCCN1C(=O)C(CC2CCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
56681915 66438 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 591 10 3 6 5.0 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813440 66438 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 591 10 3 6 5.0 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851889 66438 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 591 10 3 6 5.0 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
57331305 104650 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 566 10 0 4 5.1 CCN(Cc1ccccc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
CHEMBL3104695 104650 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 566 10 0 4 5.1 CCN(Cc1ccccc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
52941648 19076 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 822 12 1 5 8.0 C=CCN(C(=O)Cc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288917 19076 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 822 12 1 5 8.0 C=CCN(C(=O)Cc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
16728787 12847 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 533 9 2 5 4.9 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
CHEMBL1188566 12847 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 533 9 2 5 4.9 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
CHEMBL536754 12847 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 533 9 2 5 4.9 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
16728787 12847 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 533 9 2 5 4.9 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL1188566 12847 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 533 9 2 5 4.9 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL536754 12847 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 533 9 2 5 4.9 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
46225531 202629 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 522 6 0 4 3.9 Cc1ccnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL596523 202629 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 522 6 0 4 3.9 Cc1ccnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
21927225 14346 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 473 7 1 4 4.2 CC#CCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1171096 14346 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 473 7 1 4 4.2 CC#CCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1200061 14346 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 473 7 1 4 4.2 CC#CCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
6479877 12517 None 2 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2012.05.127
CHEMBL1186558 12517 None 2 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2012.05.127
CHEMBL2057533 12517 None 2 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2012.05.127
CHEMBL469649 12517 None 2 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2012.05.127
6479877 12517 None 2 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.ejmech.2012.07.049
CHEMBL1186558 12517 None 2 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.ejmech.2012.07.049
CHEMBL2057533 12517 None 2 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.ejmech.2012.07.049
CHEMBL469649 12517 None 2 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.ejmech.2012.07.049
162660784 181374 None 0 Human Functional pIC50 = 6.3 6.3 -25 2
Antagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysisAntagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysis
ChEMBL 1225 30 7 15 7.3 Cc1nnc(C(C)C)n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(=O)NCCCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)cc1 10.1016/j.bmc.2016.09.059
CHEMBL4761986 181374 None 0 Human Functional pIC50 = 6.3 6.3 -25 2
Antagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysisAntagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysis
ChEMBL 1225 30 7 15 7.3 Cc1nnc(C(C)C)n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(=O)NCCCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)cc1 10.1016/j.bmc.2016.09.059
6479877 12517 None 2 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2011.07.058
CHEMBL1186558 12517 None 2 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2011.07.058
CHEMBL2057533 12517 None 2 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2011.07.058
CHEMBL469649 12517 None 2 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2011.07.058
46225395 203750 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 503 6 0 6 2.3 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCOC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL604070 203750 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 503 6 0 6 2.3 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCOC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL5078769 217072 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR5 receptor expressed in HEK293 cells co-expressing Galpha15 assessed as inhibition of RNATES-induced intracellular calcium flux measured after 10 mins by FLIPR calcium mobilization assayAntagonist activity at human CCR5 receptor expressed in HEK293 cells co-expressing Galpha15 assessed as inhibition of RNATES-induced intracellular calcium flux measured after 10 mins by FLIPR calcium mobilization assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(C(C)=O)CC3)c3ccc(C)c(Cl)c3)CC2)cc1)C(N)=O 10.1021/acs.jmedchem.1c00781
9978318 122419 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Inhibition of MIP-1beta ligand of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assayInhibition of MIP-1beta ligand of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assay
ChEMBL 400 8 1 7 2.1 COc1ccc(/C=C/C(=O)OC(C)C(=O)[C@H]2C[C@@H]2[C@H](O)[C@H]2CC=CC(=O)O2)cc1 10.1016/j.bmcl.2004.08.021
CHEMBL359986 122419 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Inhibition of MIP-1beta ligand of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assayInhibition of MIP-1beta ligand of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assay
ChEMBL 400 8 1 7 2.1 COc1ccc(/C=C/C(=O)OC(C)C(=O)[C@H]2C[C@@H]2[C@H](O)[C@H]2CC=CC(=O)O2)cc1 10.1016/j.bmcl.2004.08.021
46225395 203750 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 503 6 0 6 2.3 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCOC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL604070 203750 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 503 6 0 6 2.3 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCOC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
46225513 203866 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 505 7 1 6 2.3 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C(C)(C)CO)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL604680 203866 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 505 7 1 6 2.3 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C(C)(C)CO)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
3001322 443 None 22 Human Functional pIC50 = 5.3 5.3 -123 4
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.bmc.2011.05.022
805 443 None 22 Human Functional pIC50 = 5.3 5.3 -123 4
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.bmc.2011.05.022
CHEMBL1255794 443 None 22 Human Functional pIC50 = 5.3 5.3 -123 4
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.bmc.2011.05.022
DB06497 443 None 22 Human Functional pIC50 = 5.3 5.3 -123 4
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.bmc.2011.05.022
73349506 92843 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 473 9 1 6 5.0 CCN(CC)c1ccc(CN2CCC(c3ccc(OC)c(NC(=O)c4cnccn4)c3)CC2)cc1 10.1016/j.ejmech.2013.09.004
CHEMBL2436814 92843 None 0 Human Functional pIC50 = 4.3 4.3 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 473 9 1 6 5.0 CCN(CC)c1ccc(CN2CCC(c3ccc(OC)c(NC(=O)c4cnccn4)c3)CC2)cc1 10.1016/j.ejmech.2013.09.004
49799707 14332 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 544 9 2 4 5.4 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(C(=O)Nc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1170873 14332 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 544 9 2 4 5.4 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(C(=O)Nc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1200014 14332 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 544 9 2 4 5.4 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(C(=O)Nc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL5074744 216817 None 0 Human Functional pIC50 = 7.2 7.2 -1 3
Antagonist activity at CCR5 (unknown origin) expressed in HOS cells co-expressing Gqi-5 assessed as inhibition CCL5-stimulated Ca2+ mobilization by calcium mobilization assayAntagonist activity at CCR5 (unknown origin) expressed in HOS cells co-expressing Gqi-5 assessed as inhibition CCL5-stimulated Ca2+ mobilization by calcium mobilization assay
ChEMBL None None None CC(C)c1nnc(CCNC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)n1C1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1 10.1021/acs.jmedchem.1c00408
21925890 14381 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 508 8 1 5 5.2 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1csc(-c3ccccc3)n1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1172870 14381 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 508 8 1 5 5.2 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1csc(-c3ccccc3)n1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1200223 14381 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 508 8 1 5 5.2 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C12CCN(Cc1csc(-c3ccccc3)n1)CC2 10.1016/j.bmc.2010.05.057
3008921 168335 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 459 5 0 3 6.3 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)C2CCCCC2)CC1 10.1021/jm031046g
CHEMBL433635 168335 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 459 5 0 3 6.3 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)C2CCCCC2)CC1 10.1021/jm031046g
46225344 202525 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 535 5 0 5 4.2 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)(C)C)CC3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL595760 202525 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 535 5 0 5 4.2 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4cccc(F)c4)CCN(C(=O)C(C)(C)C)CC3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
21927257 14327 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 569 11 1 6 5.1 CCCCN1C(=O)C(CC(=O)OCc2ccccc2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1170660 14327 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 569 11 1 6 5.1 CCCCN1C(=O)C(CC(=O)OCc2ccccc2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1199989 14327 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 569 11 1 6 5.1 CCCCN1C(=O)C(CC(=O)OCc2ccccc2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
73352534 92846 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 459 7 2 6 4.1 COc1ccc(C2CCN(Cc3ccc(NC(C)=O)cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.ejmech.2013.09.004
CHEMBL2436817 92846 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 459 7 2 6 4.1 COc1ccc(C2CCN(Cc3ccc(NC(C)=O)cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.ejmech.2013.09.004
56657984 66409 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 548 7 3 6 3.1 CNC(=O)c1ccc(Oc2ccc(CN3CCC4(CC3)C(=O)N[C@H]([C@H](O)C3CCCCC3)C(=O)N4C)cc2)cc1 10.1016/j.bmc.2011.05.022
CHEMBL1813445 66409 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 548 7 3 6 3.1 CNC(=O)c1ccc(Oc2ccc(CN3CCC4(CC3)C(=O)N[C@H]([C@H](O)C3CCCCC3)C(=O)N4C)cc2)cc1 10.1016/j.bmc.2011.05.022
CHEMBL1851766 66409 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 548 7 3 6 3.1 CNC(=O)c1ccc(Oc2ccc(CN3CCC4(CC3)C(=O)N[C@H]([C@H](O)C3CCCCC3)C(=O)N4C)cc2)cc1 10.1016/j.bmc.2011.05.022
72714320 92734 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 546 8 1 5 5.2 Cc1cccc(C2CN(C3CCCCC3)C(=O)N2C2CCN(C(C)CCNC(=O)c3c(C)ncnc3C)CC2)c1 10.1021/jm401101p
CHEMBL2435890 92734 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 546 8 1 5 5.2 Cc1cccc(C2CN(C3CCCCC3)C(=O)N2C2CCN(C(C)CCNC(=O)c3c(C)ncnc3C)CC2)c1 10.1021/jm401101p
49798080 10820 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 629 10 1 6 5.7 C=CCN(C(=O)OCc1ccc(OC(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172039 10820 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 629 10 1 6 5.7 C=CCN(C(=O)OCc1ccc(OC(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
49798088 10830 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 628 10 2 5 5.3 C=CCN(C(=O)NCc1ccc(OC(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172049 10830 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 628 10 2 5 5.3 C=CCN(C(=O)NCc1ccc(OC(F)(F)F)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
3008914 203466 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 573 6 0 3 7.2 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccc(Br)cc3)CC2)CC1 10.1021/jm031046g
CHEMBL60225 203466 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 573 6 0 3 7.2 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)c3ccc(Br)cc3)CC2)CC1 10.1021/jm031046g
16728325 10818 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 575 10 1 6 4.8 C=CCN(C(=O)OCc1ccc(OC)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1172036 10818 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 575 10 1 6 4.8 C=CCN(C(=O)OCc1ccc(OC)cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
59458159 92752 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 567 8 1 5 5.0 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
CHEMBL2435908 92752 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 567 8 1 5 5.0 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
56647076 92725 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 553 8 1 4 7.0 O=C(O)c1ccc(Oc2ccc(CN3CCC(N4C(=O)N(C5CCCCC5)C[C@H]4c4ccccc4)CC3)cc2)cc1 10.1021/jm401101p
CHEMBL2435881 92725 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 553 8 1 4 7.0 O=C(O)c1ccc(Oc2ccc(CN3CCC(N4C(=O)N(C5CCCCC5)C[C@H]4c4ccccc4)CC3)cc2)cc1 10.1021/jm401101p
11692945 76560 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 608 10 1 5 4.4 CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccccc3C(N)=O)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
CHEMBL206088 76560 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 608 10 1 5 4.4 CS(=O)(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccccc3C(N)=O)CC2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm051034q
118727174 117442 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 542 8 0 4 5.0 CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
CHEMBL3397985 117442 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 542 8 0 4 5.0 CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(F)cc3)CC2C)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
49864974 15793 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 656 9 2 4 6.1 C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)[C@@H]1C[C@@H]2CC[C@H](C1)N2C[C@H]1CN(C(=O)C2CCCC2)C[C@]1(O)c1cccc(F)c1 10.1016/j.bmcl.2010.05.046
CHEMBL1222772 15793 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 656 9 2 4 6.1 C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)[C@@H]1C[C@@H]2CC[C@H](C1)N2C[C@H]1CN(C(=O)C2CCCC2)C[C@]1(O)c1cccc(F)c1 10.1016/j.bmcl.2010.05.046
126567286 165472 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 533 8 1 6 6.3 Cc1csc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)c1 10.1021/acs.jmedchem.8b01077
CHEMBL4237581 165472 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 533 8 1 6 6.3 Cc1csc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)c1 10.1021/acs.jmedchem.8b01077
145986277 165994 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 549 9 1 7 6.0 COc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)s1 10.1021/acs.jmedchem.8b01077
CHEMBL4249941 165994 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 549 9 1 7 6.0 COc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)s1 10.1021/acs.jmedchem.8b01077
56647023 92724 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 552 8 1 4 6.4 NC(=O)c1ccc(Oc2ccc(CN3CCC(N4C(=O)N(C5CCCCC5)C[C@H]4c4ccccc4)CC3)cc2)cc1 10.1021/jm401101p
CHEMBL2435880 92724 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 552 8 1 4 6.4 NC(=O)c1ccc(Oc2ccc(CN3CCC(N4C(=O)N(C5CCCCC5)C[C@H]4c4ccccc4)CC3)cc2)cc1 10.1021/jm401101p
52944587 19067 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 837 12 2 5 8.1 C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288880 19067 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 837 12 2 5 8.1 C=CCN(C(=O)NCc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
52944617 19075 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 813 12 2 7 7.4 C=CCN(C(=O)Nc1ccc(OC(C)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288916 19075 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 813 12 2 7 7.4 C=CCN(C(=O)Nc1ccc(OC(C)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
46225531 202629 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 522 6 0 4 3.9 Cc1ccnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL596523 202629 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 522 6 0 4 3.9 Cc1ccnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
44395386 127605 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Inhibition of MIP-1beta ligand of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assayInhibition of MIP-1beta ligand of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assay
ChEMBL 400 8 1 7 2.1 COc1ccc(/C=C\C(=O)OC(C)C(=O)[C@H]2C[C@@H]2[C@H](O)[C@H]2CC=CC(=O)O2)cc1 10.1016/j.bmcl.2004.08.021
CHEMBL366260 127605 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Inhibition of MIP-1beta ligand of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assayInhibition of MIP-1beta ligand of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assay
ChEMBL 400 8 1 7 2.1 COc1ccc(/C=C\C(=O)OC(C)C(=O)[C@H]2C[C@@H]2[C@H](O)[C@H]2CC=CC(=O)O2)cc1 10.1016/j.bmcl.2004.08.021
3008934 201149 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 467 5 0 3 6.2 Cc1cccc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL58101 201149 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 467 5 0 3 6.2 Cc1cccc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
73352529 92823 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 501 10 1 6 5.7 CCN(CC)c1ccc(CN2CCC(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 10.1016/j.ejmech.2013.09.004
CHEMBL2436715 92823 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 501 10 1 6 5.7 CCN(CC)c1ccc(CN2CCC(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 10.1016/j.ejmech.2013.09.004
73346461 92851 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 461 8 1 7 4.4 CCOc1ccc(C2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.ejmech.2013.09.004
CHEMBL2436823 92851 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 461 8 1 7 4.4 CCOc1ccc(C2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.ejmech.2013.09.004
3008937 202556 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 469 5 0 5 5.0 Cc1ncnc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL59602 202556 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 469 5 0 5 5.0 Cc1ncnc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
90666577 109454 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challengeAntagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challenge
ChEMBL 886 25 5 11 4.9 CNC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)Nc1ccc([C@H](CCN2C3CCC2CC(n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)cc1 10.1039/c3md00080j
CHEMBL3219779 109454 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challengeAntagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challenge
ChEMBL 886 25 5 11 4.9 CNC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)Nc1ccc([C@H](CCN2C3CCC2CC(n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)cc1 10.1039/c3md00080j
101577042 183248 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysisAntagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysis
ChEMBL 886 25 5 11 4.9 CNC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)Nc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)cc1 10.1016/j.bmc.2016.09.059
CHEMBL4795179 183248 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysisAntagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysis
ChEMBL 886 25 5 11 4.9 CNC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)Nc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)cc1 10.1016/j.bmc.2016.09.059
112500047 124537 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.
ChEMBL 643 13 3 8 4.4 Cc1nnc(C(C)C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(N)=O)cc1 nan
CHEMBL3639964 124537 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.Flux Assay: Then the Ca2+ functional activity of bivalent ligand 1 was evaluated in the Gqi5 transfected CCR5-MOLT-4 cells as described in the literature.3 As expected, no CCR5 agonism was detected for the bivalent ligand 1 (data not shown). In the RANTES induced Ca2+ flux inhibition assay (Table 3), the bivalent ligand 1 was approximately 60-fold less potent than maraviroc. A more significant potency decrease (nearly 300 times) was observed for the monovalent ligand 3, compared to maraviroc. In order to figure out the possible reasons for such a dramatic drop of their potency, two analogues (4 and 5, FIG. 14) of mavaviroc carrying gradient steric hindrance characters at the same substitution position were evaluated under the same condition. Compound 4 showed a modest reduction of the potency (Table 2). However, the inhibition potency of the N-t-Boc protected analogue 5 dropped to micromolar (IC50=1.57+/-0.18 uM). It thus appeared that steric hindrance may play an essential role.
ChEMBL 643 13 3 8 4.4 Cc1nnc(C(C)C)n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccc(NC(=O)COCC(N)=O)cc1 nan
118727192 117460 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 430 7 1 4 4.5 N#Cc1ccc(N2CCN(CCC(NC(=O)C3CCCCC3)c3ccccc3)CC2)cc1 10.1016/j.bmc.2014.12.052
CHEMBL3398003 117460 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 430 7 1 4 4.5 N#Cc1ccc(N2CCN(CCC(NC(=O)C3CCCCC3)c3ccccc3)CC2)cc1 10.1016/j.bmc.2014.12.052
90656330 111131 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 465 7 1 6 4.5 CC(C)Oc1ccc(N2CCN(Cc3ccc(Cl)cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.bmcl.2014.03.073
CHEMBL3263026 111131 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 465 7 1 6 4.5 CC(C)Oc1ccc(N2CCN(Cc3ccc(Cl)cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.bmcl.2014.03.073
49798349 10795 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at CCR5Antagonist activity at CCR5
ChEMBL 471 6 2 4 5.9 O=C(O)c1ccccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2010.04.142
CHEMBL1171786 10795 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at CCR5Antagonist activity at CCR5
ChEMBL 471 6 2 4 5.9 O=C(O)c1ccccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2010.04.142
73347961 92849 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 429 7 2 4 5.3 CCOc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1ccccc1 10.1016/j.ejmech.2013.09.004
CHEMBL2436820 92849 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 429 7 2 4 5.3 CCOc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1ccccc1 10.1016/j.ejmech.2013.09.004
73347961 92849 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 429 7 2 4 5.3 CCOc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1ccccc1 10.1016/j.bmcl.2014.03.073
CHEMBL2436820 92849 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 429 7 2 4 5.3 CCOc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1ccccc1 10.1016/j.bmcl.2014.03.073
10416 1879 None 31 Human Functional pIC50 = 5.2 5.2 -309 3
Antagonist activity at CCR5 receptor (unknown origin) by [35S]GTPgammaS binding assayAntagonist activity at CCR5 receptor (unknown origin) by [35S]GTPgammaS binding assay
ChEMBL 548 9 3 8 4.0 COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl 10.1021/jm301572h
46861584 1879 None 31 Human Functional pIC50 = 5.2 5.2 -309 3
Antagonist activity at CCR5 receptor (unknown origin) by [35S]GTPgammaS binding assayAntagonist activity at CCR5 receptor (unknown origin) by [35S]GTPgammaS binding assay
ChEMBL 548 9 3 8 4.0 COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl 10.1021/jm301572h
CHEMBL2018969 1879 None 31 Human Functional pIC50 = 5.2 5.2 -309 3
Antagonist activity at CCR5 receptor (unknown origin) by [35S]GTPgammaS binding assayAntagonist activity at CCR5 receptor (unknown origin) by [35S]GTPgammaS binding assay
ChEMBL 548 9 3 8 4.0 COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl 10.1021/jm301572h
52947064 19066 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 823 11 2 5 8.5 C=CCN(C(=O)Nc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288879 19066 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 823 11 2 5 8.5 C=CCN(C(=O)Nc1ccc(C(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
10278617 95235 None 3 Crab-eating macaque Functional pIC50 = 7.2 7.2 -1 2
Antagonist activity at cynomolgus monkey CCR5 expressed in CHO cells assessed as MIP-1-alpha-induced Ca2+ mobilizationAntagonist activity at cynomolgus monkey CCR5 expressed in CHO cells assessed as MIP-1-alpha-induced Ca2+ mobilization
ChEMBL 499 5 0 5 4.6 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1 10.1016/j.bmcl.2008.01.108
CHEMBL255858 95235 None 3 Crab-eating macaque Functional pIC50 = 7.2 7.2 -1 2
Antagonist activity at cynomolgus monkey CCR5 expressed in CHO cells assessed as MIP-1-alpha-induced Ca2+ mobilizationAntagonist activity at cynomolgus monkey CCR5 expressed in CHO cells assessed as MIP-1-alpha-induced Ca2+ mobilization
ChEMBL 499 5 0 5 4.6 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1 10.1016/j.bmcl.2008.01.108
57331304 104638 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 552 9 0 4 4.7 CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)N(C)Cc3ccccc3)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
CHEMBL3104681 104638 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 552 9 0 4 4.7 CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)N(C)Cc3ccccc3)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
73357100 92847 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 485 10 1 4 6.6 CCOc1ccc(C2CCN(Cc3ccc(N(CC)CC)cc3)CC2)cc1NC(=O)c1ccccc1 10.1016/j.ejmech.2013.09.004
CHEMBL2436818 92847 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 485 10 1 4 6.6 CCOc1ccc(C2CCN(Cc3ccc(N(CC)CC)cc3)CC2)cc1NC(=O)c1ccccc1 10.1016/j.ejmech.2013.09.004
90656326 111128 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 476 8 1 8 3.7 CC(C)Oc1ccc(N2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.bmcl.2014.03.073
CHEMBL3263022 111128 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 476 8 1 8 3.7 CC(C)Oc1ccc(N2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.bmcl.2014.03.073
52949553 19078 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 832 13 1 7 6.4 C=CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288919 19078 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 832 13 1 7 6.4 C=CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
46225394 202566 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 501 6 0 5 3.5 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCCC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL596081 202566 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 501 6 0 5 3.5 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCCC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
16658856 66498 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2012.05.127
CHEMBL1817909 66498 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2012.05.127
CHEMBL1852220 66498 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2012.05.127
CHEMBL2057810 66498 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2012.05.127
16658856 66498 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.ejmech.2012.07.049
CHEMBL1817909 66498 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.ejmech.2012.07.049
CHEMBL1852220 66498 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.ejmech.2012.07.049
CHEMBL2057810 66498 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.ejmech.2012.07.049
16658856 66498 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2011.07.058
CHEMBL1817909 66498 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2011.07.058
CHEMBL1852220 66498 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2011.07.058
CHEMBL2057810 66498 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C/c1c(C)c(/C=C/CCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2011.07.058
73349499 92824 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 475 8 1 7 4.8 CC(C)Oc1ccc(C2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.ejmech.2013.09.004
CHEMBL2436716 92824 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 475 8 1 7 4.8 CC(C)Oc1ccc(C2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.ejmech.2013.09.004
46225529 202151 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 591 6 0 5 4.3 Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL593195 202151 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 591 6 0 5 4.3 Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
145961982 161626 None 0 Human Functional pIC50 = 6.2 6.2 -10 2
Antagonist activity at CCR5 (unknown origin) expressed in CHOK1 cells co-expressing Ga16 assessed as inhibition of Rantes-induced intracellular Ca2+ mobilization preincubated for 10 mins followed by Rantes addition by fluo-4 AM dye based assayAntagonist activity at CCR5 (unknown origin) expressed in CHOK1 cells co-expressing Ga16 assessed as inhibition of Rantes-induced intracellular Ca2+ mobilization preincubated for 10 mins followed by Rantes addition by fluo-4 AM dye based assay
ChEMBL 553 8 1 6 4.3 CN(C1CCN(CCCN2CCCc3c(ccnc3Nc3ccc(Cl)c(Cl)c3)C2=O)CC1)S(C)(=O)=O 10.1016/j.bmc.2018.05.027
CHEMBL4128498 161626 None 0 Human Functional pIC50 = 6.2 6.2 -10 2
Antagonist activity at CCR5 (unknown origin) expressed in CHOK1 cells co-expressing Ga16 assessed as inhibition of Rantes-induced intracellular Ca2+ mobilization preincubated for 10 mins followed by Rantes addition by fluo-4 AM dye based assayAntagonist activity at CCR5 (unknown origin) expressed in CHOK1 cells co-expressing Ga16 assessed as inhibition of Rantes-induced intracellular Ca2+ mobilization preincubated for 10 mins followed by Rantes addition by fluo-4 AM dye based assay
ChEMBL 553 8 1 6 4.3 CN(C1CCN(CCCN2CCCc3c(ccnc3Nc3ccc(Cl)c(Cl)c3)C2=O)CC1)S(C)(=O)=O 10.1016/j.bmc.2018.05.027
56661524 66452 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 549 10 3 6 3.8 CCCCN1C(=O)[C@@H]([C@H](O)C2CCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813438 66452 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 549 10 3 6 3.8 CCCCN1C(=O)[C@@H]([C@H](O)C2CCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851951 66452 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 549 10 3 6 3.8 CCCCN1C(=O)[C@@H]([C@H](O)C2CCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
73354018 92821 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 443 7 2 4 5.7 CC(C)Oc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1ccccc1 10.1016/j.ejmech.2013.09.004
CHEMBL2436713 92821 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 443 7 2 4 5.7 CC(C)Oc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1ccccc1 10.1016/j.ejmech.2013.09.004
46225394 202566 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 501 6 0 5 3.5 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCCC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL596081 202566 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 501 6 0 5 3.5 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCCC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
3008918 201840 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 467 5 0 3 6.3 Cc1ccccc1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL59101 201840 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 467 5 0 3 6.3 Cc1ccccc1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
126567281 165605 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 520 8 1 7 5.4 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cscn1 10.1021/acs.jmedchem.2c01383
CHEMBL4240742 165605 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 520 8 1 7 5.4 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cscn1 10.1021/acs.jmedchem.2c01383
122185625 122973 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 504 8 2 6 3.2 Cc1c(CNC(=O)c2ccc([N+](=O)[O-])cc2)c(C)[n+]2c(c1CNC(=O)c1ccc([N+](=O)[O-])cc1)CCC2 10.1016/j.bmcl.2015.06.029
CHEMBL3604304 122973 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 504 8 2 6 3.2 Cc1c(CNC(=O)c2ccc([N+](=O)[O-])cc2)c(C)[n+]2c(c1CNC(=O)c1ccc([N+](=O)[O-])cc1)CCC2 10.1016/j.bmcl.2015.06.029
CHEMBL3606026 122973 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 504 8 2 6 3.2 Cc1c(CNC(=O)c2ccc([N+](=O)[O-])cc2)c(C)[n+]2c(c1CNC(=O)c1ccc([N+](=O)[O-])cc1)CCC2 10.1016/j.bmcl.2015.06.029
168284187 190964 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 519 7 1 6 5.9 Cc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C(F)(F)F)c1csc2ccccc12 10.1021/acs.jmedchem.2c01383
CHEMBL5184527 190964 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 519 7 1 6 5.9 Cc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C(F)(F)F)c1csc2ccccc12 10.1021/acs.jmedchem.2c01383
23577370 66385 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 549 9 3 6 4.6 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813270 66385 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 549 9 3 6 4.6 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851623 66385 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 549 9 3 6 4.6 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
56681917 66457 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 604 11 3 6 4.6 CCCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813450 66457 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 604 11 3 6 4.6 CCCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851972 66457 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 604 11 3 6 4.6 CCCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
46225429 202541 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 527 5 0 5 4.2 Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C(C)(C)C)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL595902 202541 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human CCR5Antagonist activity at human CCR5
ChEMBL 527 5 0 5 4.2 Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C(C)(C)C)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
21926618 14345 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 475 8 1 4 4.8 C/C=C/CN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1171095 14345 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 475 8 1 4 4.8 C/C=C/CN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1200060 14345 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 475 8 1 4 4.8 C/C=C/CN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
122185635 122985 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 474 8 2 4 3.4 COc1ccc(C(=O)NCc2c(C)c(CNC(=O)c3ccc(OC)cc3)c3[n+](c2C)CCC3)cc1 10.1016/j.bmcl.2015.06.029
CHEMBL3604309 122985 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 474 8 2 4 3.4 COc1ccc(C(=O)NCc2c(C)c(CNC(=O)c3ccc(OC)cc3)c3[n+](c2C)CCC3)cc1 10.1016/j.bmcl.2015.06.029
CHEMBL3606103 122985 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 474 8 2 4 3.4 COc1ccc(C(=O)NCc2c(C)c(CNC(=O)c3ccc(OC)cc3)c3[n+](c2C)CCC3)cc1 10.1016/j.bmcl.2015.06.029
44511966 69235 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 515 10 1 6 5.1 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cncc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
CHEMBL1926889 69235 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 515 10 1 6 5.1 COc1ccc(N(Cc2cnccc2C)C2CCN([C@H](C)CCNC(=O)c3c(C)cncc3C)CC2)cc1 10.1016/j.bmcl.2011.09.133
57394058 69251 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 510 9 1 6 5.0 Cc1ccncc1CN(c1ccccc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(C#N)nc2C)CC1 10.1016/j.bmcl.2011.09.133
CHEMBL1926905 69251 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 510 9 1 6 5.0 Cc1ccncc1CN(c1ccccc1)C1CCN([C@H](C)CCNC(=O)c2c(C)cc(C#N)nc2C)CC1 10.1016/j.bmcl.2011.09.133
21867666 162153 None 52 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 (unknown origin) by HTS assayAntagonist activity at CCR5 (unknown origin) by HTS assay
ChEMBL 112 0 2 2 -0.6 C1NCC2CNCC12 10.1016/j.ejmech.2018.01.085
CHEMBL4160473 162153 None 52 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 (unknown origin) by HTS assayAntagonist activity at CCR5 (unknown origin) by HTS assay
ChEMBL 112 0 2 2 -0.6 C1NCC2CNCC12 10.1016/j.ejmech.2018.01.085
76313867 104649 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in CHO cell membranes assessed as inhibition of RANTES-stimulated [35S]-GTPgammaS binding after 1 hr by liquid scintillation counting analysisAntagonist activity at CCR5 (unknown origin) expressed in CHO cell membranes assessed as inhibition of RANTES-stimulated [35S]-GTPgammaS binding after 1 hr by liquid scintillation counting analysis
ChEMBL 566 10 0 4 4.9 CCN(C(=O)Cc1ccccc1)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
CHEMBL3104694 104649 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in CHO cell membranes assessed as inhibition of RANTES-stimulated [35S]-GTPgammaS binding after 1 hr by liquid scintillation counting analysisAntagonist activity at CCR5 (unknown origin) expressed in CHO cell membranes assessed as inhibition of RANTES-stimulated [35S]-GTPgammaS binding after 1 hr by liquid scintillation counting analysis
ChEMBL 566 10 0 4 4.9 CCN(C(=O)Cc1ccccc1)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
5275760 77092 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 623 10 0 6 5.1 COC(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(S(C)(=O)=O)CC3)c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1021/jm051034q
CHEMBL207301 77092 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 623 10 0 6 5.1 COC(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(S(C)(=O)=O)CC3)c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1021/jm051034q
72711278 92742 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 564 8 1 5 5.3 Cc1cc(F)cc(C2CN(C3CCCCC3)C(=O)N2C2CCN(C(C)CCNC(=O)c3c(C)ncnc3C)CC2)c1 10.1021/jm401101p
CHEMBL2435898 92742 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 564 8 1 5 5.3 Cc1cc(F)cc(C2CN(C3CCCCC3)C(=O)N2C2CCN(C(C)CCNC(=O)c3c(C)ncnc3C)CC2)c1 10.1021/jm401101p
3008935 205186 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 468 5 0 4 5.6 Cc1ccnc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL61828 205186 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 468 5 0 4 5.6 Cc1ccnc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
73346389 92723 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 580 8 0 4 7.0 CN(C)C(=O)c1ccc(Oc2ccc(CN3CCC(N4C(=O)N(C5CCCCC5)C[C@H]4c4ccccc4)CC3)cc2)cc1 10.1021/jm401101p
CHEMBL2435879 92723 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 580 8 0 4 7.0 CN(C)C(=O)c1ccc(Oc2ccc(CN3CCC(N4C(=O)N(C5CCCCC5)C[C@H]4c4ccccc4)CC3)cc2)cc1 10.1021/jm401101p
72711507 92747 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 525 9 1 4 5.2 CCCN1C[C@@H](c2ccccc2)N(C2CCN(C(C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)C1=O 10.1021/jm401101p
CHEMBL2435903 92747 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 525 9 1 4 5.2 CCCN1C[C@@H](c2ccccc2)N(C2CCN(C(C)CCNC(=O)c3c(C)cc(Cl)nc3C)CC2)C1=O 10.1021/jm401101p
16728787 12847 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assayAntagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay
ChEMBL 533 9 2 5 4.9 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL1188566 12847 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assayAntagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay
ChEMBL 533 9 2 5 4.9 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL536754 12847 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assayAntagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay
ChEMBL 533 9 2 5 4.9 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
3008918 201840 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 467 5 0 3 6.3 Cc1ccccc1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL59101 201840 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 467 5 0 3 6.3 Cc1ccccc1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
183790 3742 None 8 Human Functional pIC50 = 8.1 8.1 -2 5
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C 10.1016/j.bmcl.2011.07.058
783 3742 None 8 Human Functional pIC50 = 8.1 8.1 -2 5
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C 10.1016/j.bmcl.2011.07.058
CHEMBL1178786 3742 None 8 Human Functional pIC50 = 8.1 8.1 -2 5
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C 10.1016/j.bmcl.2011.07.058
3008932 205103 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonistic activity against human C-C chemokine receptor type 5Antagonistic activity against human C-C chemokine receptor type 5
ChEMBL 560 6 0 6 6.5 Cc1nc(-c2ccncc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL61373 205103 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonistic activity against human C-C chemokine receptor type 5Antagonistic activity against human C-C chemokine receptor type 5
ChEMBL 560 6 0 6 6.5 Cc1nc(-c2ccncc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
3008932 205103 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 560 6 0 6 6.5 Cc1nc(-c2ccncc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL61373 205103 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 560 6 0 6 6.5 Cc1nc(-c2ccncc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
3008923 201355 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 521 5 0 3 7.3 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2c(Cl)cccc2Cl)CC1 10.1021/jm031046g
CHEMBL58441 201355 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 521 5 0 3 7.3 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2c(Cl)cccc2Cl)CC1 10.1021/jm031046g
3008928 205114 None 0 Human Functional pIC50 = 8.1 8.1 -1 2
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 483 5 0 5 5.4 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL61424 205114 None 0 Human Functional pIC50 = 8.1 8.1 -1 2
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
ChEMBL 483 5 0 5 5.4 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
168296928 192349 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 576 9 1 8 4.2 Cc1ccc([C@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCN(S(C)(=O)=O)CC2)s1 10.1021/acs.jmedchem.2c01383
CHEMBL5205216 192349 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 576 9 1 8 4.2 Cc1ccc([C@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCN(S(C)(=O)=O)CC2)s1 10.1021/acs.jmedchem.2c01383
72711051 92740 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 610 8 1 5 5.6 Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccc(Br)cc2)CC1 10.1021/jm401101p
CHEMBL2435896 92740 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 610 8 1 5 5.6 Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccc(Br)cc2)CC1 10.1021/jm401101p
73346454 92830 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 457 7 2 4 5.3 COc1ccc(C2CCN(Cc3ccc(NC(C)=O)cc3)CC2)cc1NC(=O)c1ccccc1 10.1016/j.ejmech.2013.09.004
CHEMBL2436722 92830 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 457 7 2 4 5.3 COc1ccc(C2CCN(Cc3ccc(NC(C)=O)cc3)CC2)cc1NC(=O)c1ccccc1 10.1016/j.ejmech.2013.09.004
49799680 14386 None 1 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 502 8 1 4 5.2 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(-c3cccnc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1200241 14386 None 1 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 502 8 1 4 5.2 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(-c3cccnc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL3217146 14386 None 1 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 502 8 1 4 5.2 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(-c3cccnc3)cc1)CC2 10.1016/j.bmc.2010.05.057
23577378 66453 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 563 10 2 6 4.9 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(OC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813269 66453 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 563 10 2 6 4.9 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(OC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851957 66453 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 563 10 2 6 4.9 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(OC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
3013673 76987 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 461 8 0 3 4.6 CC(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccccc3)CC2)c2ccccc2)CC1 10.1021/jm051034q
CHEMBL207085 76987 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 461 8 0 3 4.6 CC(=O)N1CCC(C(=O)N(CCCN2CCC(Cc3ccccc3)CC2)c2ccccc2)CC1 10.1021/jm051034q
122668217 192375 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 454 8 1 7 4.4 Cc1ccc([C@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)CC#N)s1 10.1021/acs.jmedchem.2c01383
CHEMBL5205626 192375 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 454 8 1 7 4.4 Cc1ccc([C@H](CCN2[C@@H]3CC[C@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)CC#N)s1 10.1021/acs.jmedchem.2c01383
44395365 124540 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Inhibition of MIP-1beta ligand of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assayInhibition of MIP-1beta ligand of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assay
ChEMBL 386 7 2 7 1.8 CC(OC(=O)/C=C/c1ccc(O)cc1)C(=O)[C@H]1C[C@@H]1[C@H](O)[C@H]1CC=CC(=O)O1 10.1016/j.bmcl.2004.08.021
CHEMBL363999 124540 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Inhibition of MIP-1beta ligand of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assayInhibition of MIP-1beta ligand of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assay
ChEMBL 386 7 2 7 1.8 CC(OC(=O)/C=C/c1ccc(O)cc1)C(=O)[C@H]1C[C@@H]1[C@H](O)[C@H]1CC=CC(=O)O1 10.1016/j.bmcl.2004.08.021
73355552 92844 None 0 Human Functional pIC50 = 4.1 4.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 447 7 1 7 4.0 COc1ccc(C2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.ejmech.2013.09.004
CHEMBL2436815 92844 None 0 Human Functional pIC50 = 4.1 4.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 447 7 1 7 4.0 COc1ccc(C2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.ejmech.2013.09.004
23577382 66459 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 590 10 3 6 4.2 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813432 66459 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 590 10 3 6 4.2 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851977 66459 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 590 10 3 6 4.2 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
3008916 162455 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 509 7 0 3 6.5 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)Cc3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL416512 162455 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 509 7 0 3 6.5 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)Cc3ccccc3)CC2)CC1 10.1021/jm031046g
57331339 104642 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 563 9 1 5 4.2 CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCc3ccc(C#N)cc3)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
CHEMBL3104685 104642 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 563 9 1 5 4.2 CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCc3ccc(C#N)cc3)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
57331275 104643 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 552 10 1 4 4.4 CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCCc3ccccc3)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
CHEMBL3104688 104643 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 552 10 1 4 4.4 CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCCc3ccccc3)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
10182763 13901 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 419 6 1 3 3.6 CC(C)C[C@H]1NC(=O)C2(CCN(Cc3ccccc3)CC2)N(Cc2ccccc2)C1=O 10.1021/jm060051s
CHEMBL1196226 13901 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 419 6 1 3 3.6 CC(C)C[C@H]1NC(=O)C2(CCN(Cc3ccccc3)CC2)N(Cc2ccccc2)C1=O 10.1021/jm060051s
CHEMBL556188 13901 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 419 6 1 3 3.6 CC(C)C[C@H]1NC(=O)C2(CCN(Cc3ccccc3)CC2)N(Cc2ccccc2)C1=O 10.1021/jm060051s
73347956 92829 None 0 Human Functional pIC50 = 4.1 4.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 415 6 2 4 4.9 COc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1ccccc1 10.1016/j.ejmech.2013.09.004
CHEMBL2436721 92829 None 0 Human Functional pIC50 = 4.1 4.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 415 6 2 4 4.9 COc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1ccccc1 10.1016/j.ejmech.2013.09.004
73355549 92825 None 0 Human Functional pIC50 = 4.1 4.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 445 7 2 6 4.5 CC(C)Oc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.ejmech.2013.09.004
CHEMBL2436717 92825 None 0 Human Functional pIC50 = 4.1 4.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 445 7 2 6 4.5 CC(C)Oc1ccc(C2CCN(Cc3ccc(N)cc3)CC2)cc1NC(=O)c1cnccn1 10.1016/j.ejmech.2013.09.004
16728787 12847 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 533 9 2 5 4.9 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1188566 12847 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 533 9 2 5 4.9 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL536754 12847 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 533 9 2 5 4.9 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2011.05.022
56669616 66485 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 428 18 0 0 8.9 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2012.05.127
CHEMBL1817910 66485 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 428 18 0 0 8.9 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2012.05.127
CHEMBL1852129 66485 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 428 18 0 0 8.9 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2012.05.127
CHEMBL2057811 66485 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 428 18 0 0 8.9 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2012.05.127
56669616 66485 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 428 18 0 0 8.9 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.ejmech.2012.07.049
CHEMBL1817910 66485 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 428 18 0 0 8.9 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.ejmech.2012.07.049
CHEMBL1852129 66485 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 428 18 0 0 8.9 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.ejmech.2012.07.049
CHEMBL2057811 66485 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 428 18 0 0 8.9 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.ejmech.2012.07.049
56669616 66485 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 428 18 0 0 8.9 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2011.07.058
CHEMBL1817910 66485 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 428 18 0 0 8.9 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2011.07.058
CHEMBL1852129 66485 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 428 18 0 0 8.9 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2011.07.058
CHEMBL2057811 66485 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 428 18 0 0 8.9 CCCCCCCCCCc1c(C)c(CCCCCCCCCC)c2[n+](c1C)CCC2 10.1016/j.bmcl.2011.07.058
16728784 12801 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 493 9 2 5 4.1 CCCCN1C(=O)C(CC(C)(C)O)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
CHEMBL1188107 12801 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 493 9 2 5 4.1 CCCCN1C(=O)C(CC(C)(C)O)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
CHEMBL535172 12801 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 493 9 2 5 4.1 CCCCN1C(=O)C(CC(C)(C)O)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
21064126 14351 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 491 8 1 4 5.4 CCCCN1C(=O)[C@H](CC(C)(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1171290 14351 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 491 8 1 4 5.4 CCCCN1C(=O)[C@H](CC(C)(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1200079 14351 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 491 8 1 4 5.4 CCCCN1C(=O)[C@H](CC(C)(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
21064297 14410 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 531 9 1 4 6.2 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C)cc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1173710 14410 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 531 9 1 4 6.2 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C)cc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1200301 14410 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 531 9 1 4 6.2 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C)cc3)cc1)CC2 10.1016/j.bmc.2010.05.057
46226124 14123 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 545 10 1 4 6.3 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(C)cc3)c1)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL1198013 14123 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 545 10 1 4 6.3 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(C)cc3)c1)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL593204 14123 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 545 10 1 4 6.3 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(C)cc3)c1)CC2 10.1016/j.bmcl.2009.11.018
90666580 109457 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challengeAntagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challenge
ChEMBL 657 13 3 8 4.7 CNC(=O)COCC(=O)Nc1ccc([C@H](CCN2C3CCC2CC(n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)cc1 10.1039/c3md00080j
CHEMBL3219782 109457 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challengeAntagonist activity at CCR5 in Gqi5 transfected human MOLT4 cells assessed as inhibition of RANTES-stimulated Ca2+ influx preincubated for 15 mins followed by DAMGO challenge
ChEMBL 657 13 3 8 4.7 CNC(=O)COCC(=O)Nc1ccc([C@H](CCN2C3CCC2CC(n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)cc1 10.1039/c3md00080j
57390535 69229 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 613 9 1 5 6.7 CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2cccc(C#N)c2)c2ccc(Br)cc2)CC1 10.1016/j.bmcl.2011.09.133
CHEMBL1926883 69229 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 613 9 1 5 6.7 CC(CCNC(=O)c1c(Cl)cncc1Cl)N1CCC(N(Cc2cccc(C#N)c2)c2ccc(Br)cc2)CC1 10.1016/j.bmcl.2011.09.133
3002977 2460 None 43 Human Functional pIC50 = 8.1 8.1 2 4
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.8b01077
3002977.0 2460 None 43 Human Functional pIC50 = 8.1 8.1 2 4
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.8b01077
803 2460 None 43 Human Functional pIC50 = 8.1 8.1 2 4
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.8b01077
806 2460 None 43 Human Functional pIC50 = 8.1 8.1 2 4
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.8b01077
CHEMBL1201187 2460 None 43 Human Functional pIC50 = 8.1 8.1 2 4
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.8b01077
CHEMBL256907 2460 None 43 Human Functional pIC50 = 8.1 8.1 2 4
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.8b01077
CHEMBL584744 2460 None 43 Human Functional pIC50 = 8.1 8.1 2 4
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.8b01077
DB04835 2460 None 43 Human Functional pIC50 = 8.1 8.1 2 4
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.8b01077
3002977 2460 None 43 Human Functional pIC50 = 8.1 8.1 2 4
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.2c01383
3002977.0 2460 None 43 Human Functional pIC50 = 8.1 8.1 2 4
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.2c01383
803 2460 None 43 Human Functional pIC50 = 8.1 8.1 2 4
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.2c01383
806 2460 None 43 Human Functional pIC50 = 8.1 8.1 2 4
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.2c01383
CHEMBL1201187 2460 None 43 Human Functional pIC50 = 8.1 8.1 2 4
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.2c01383
CHEMBL256907 2460 None 43 Human Functional pIC50 = 8.1 8.1 2 4
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.2c01383
CHEMBL584744 2460 None 43 Human Functional pIC50 = 8.1 8.1 2 4
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.2c01383
DB04835 2460 None 43 Human Functional pIC50 = 8.1 8.1 2 4
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.2c01383
145985237 165619 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 533 8 1 6 6.3 Cc1cscc1[C@H](CCN1[C@H]2CC[C@@H]1C[C@@H](n1c(C)nnc1C(C)C)C2)NC(=O)C1CCC(F)(F)CC1 10.1021/acs.jmedchem.8b01077
CHEMBL4241066 165619 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 533 8 1 6 6.3 Cc1cscc1[C@H](CCN1[C@H]2CC[C@@H]1C[C@@H](n1c(C)nnc1C(C)C)C2)NC(=O)C1CCC(F)(F)CC1 10.1021/acs.jmedchem.8b01077
3008937 202556 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 469 5 0 5 5.0 Cc1ncnc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL59602 202556 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 469 5 0 5 5.0 Cc1ncnc(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
5275764 76063 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 636 10 0 5 5.0 CN(C)C(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(S(C)(=O)=O)CC3)c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1021/jm051034q
CHEMBL205706 76063 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 636 10 0 5 5.0 CN(C)C(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(S(C)(=O)=O)CC3)c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1021/jm051034q
118727171 117439 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 549 8 0 5 4.7 CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(C#N)cc3)CC2C)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
CHEMBL3397982 117439 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 549 8 0 5 4.7 CC(=O)N1CCC(C(=O)N(CCCN2CCN(Cc3ccc(C#N)cc3)CC2C)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
122668179 192606 None 2 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 601 8 1 6 6.0 Cc1nc2c(n1[C@@H]1C[C@H]3CC[C@@H](C1)N3CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccsc1)CCN(C(=O)C(C)C)C2 10.1021/acs.jmedchem.2c01383
CHEMBL5209067 192606 None 2 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 601 8 1 6 6.0 Cc1nc2c(n1[C@@H]1C[C@H]3CC[C@@H](C1)N3CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccsc1)CCN(C(=O)C(C)C)C2 10.1021/acs.jmedchem.2c01383
3008931 205104 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 559 6 0 5 7.1 Cc1nc(-c2ccccc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL61374 205104 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 559 6 0 5 7.1 Cc1nc(-c2ccccc2)nc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
52948264 19059 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 815 13 1 8 7.5 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288872 19059 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 815 13 1 8 7.5 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
16728324 10811 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 545 9 1 5 4.8 C=CCN(C(=O)OCc1ccccc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
CHEMBL1171965 10811 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
ChEMBL 545 9 1 5 4.8 C=CCN(C(=O)OCc1ccccc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2ccccc2)CC1 10.1016/j.bmcl.2010.05.102
118727186 117454 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 540 8 0 4 4.7 CC(=O)N1CCC(C(=O)N(CCCN2C[C@@H]3C[C@H]2CN3Cc2ccc(F)cc2)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
CHEMBL3397997 117454 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 540 8 0 4 4.7 CC(=O)N1CCC(C(=O)N(CCCN2C[C@@H]3C[C@H]2CN3Cc2ccc(F)cc2)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
49864969 15788 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 608 10 1 7 4.9 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2cccc(F)c2)CC1 10.1016/j.bmcl.2010.05.046
CHEMBL1222767 15788 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
ChEMBL 608 10 1 7 4.9 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@]2(O)c2cccc(F)c2)CC1 10.1016/j.bmcl.2010.05.046
3008924 202159 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 503 5 0 3 7.1 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2cccc3ccccc23)CC1 10.1021/jm031046g
CHEMBL59328 202159 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
ChEMBL 503 5 0 3 7.1 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2cccc3ccccc23)CC1 10.1021/jm031046g
3008903 163273 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 537 6 0 5 5.0 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3C#N)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL418120 163273 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 537 6 0 5 5.0 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3C#N)c3ccccc3)CC2)CC1 10.1021/jm031046g
72712158 92709 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 609 9 2 5 5.4 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCC(C(=O)O)CC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
CHEMBL2435865 92709 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 609 9 2 5 5.4 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCC(C(=O)O)CC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
122185627 122983 None 0 Human Functional pIC50 = 4.1 4.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 450 6 2 2 3.7 Cc1c(CNC(=O)c2ccc(F)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(F)cc1)CCC2 10.1016/j.bmcl.2015.06.029
CHEMBL3604305 122983 None 0 Human Functional pIC50 = 4.1 4.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 450 6 2 2 3.7 Cc1c(CNC(=O)c2ccc(F)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(F)cc1)CCC2 10.1016/j.bmcl.2015.06.029
CHEMBL3606099 122983 None 0 Human Functional pIC50 = 4.1 4.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hrAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of CCL5-induced calcium mobilization after 1 hr
ChEMBL 450 6 2 2 3.7 Cc1c(CNC(=O)c2ccc(F)cc2)c(C)[n+]2c(c1CNC(=O)c1ccc(F)cc1)CCC2 10.1016/j.bmcl.2015.06.029
49799705 14406 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 529 9 1 4 5.4 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(C(=O)c3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1173646 14406 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 529 9 1 4 5.4 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(C(=O)c3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1200294 14406 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 529 9 1 4 5.4 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(C(=O)c3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
56661522 66672 None 0 Human Functional pIC50 = 4.1 4.1 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 535 10 3 6 3.4 CCCCN1C(=O)[C@@H]([C@H](O)C2CC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813437 66672 None 0 Human Functional pIC50 = 4.1 4.1 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 535 10 3 6 3.4 CCCCN1C(=O)[C@@H]([C@H](O)C2CC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1852861 66672 None 0 Human Functional pIC50 = 4.1 4.1 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 535 10 3 6 3.4 CCCCN1C(=O)[C@@H]([C@H](O)C2CC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
126567273 165935 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 514 8 1 6 5.3 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cccnc1 10.1021/acs.jmedchem.8b01077
CHEMBL4248733 165935 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 514 8 1 6 5.3 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cccnc1 10.1021/acs.jmedchem.8b01077
72711279 92743 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 533 8 1 6 4.3 Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2cccnc2)CC1 10.1021/jm401101p
CHEMBL2435899 92743 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 533 8 1 6 4.3 Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2cccnc2)CC1 10.1021/jm401101p
11569805 13930 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)[C@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
CHEMBL1196449 13930 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)[C@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
CHEMBL556995 13930 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)[C@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
16659334 14009 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 493 9 2 5 4.0 CCCCN1C(=O)[C@@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL1197042 14009 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 493 9 2 5 4.0 CCCCN1C(=O)[C@@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL559168 14009 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 493 9 2 5 4.0 CCCCN1C(=O)[C@@H]([C@H](O)C(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
11569805 13930 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)[C@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1196449 13930 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)[C@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL556995 13930 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)[C@H](CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
56683103 66495 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 452 16 0 0 9.8 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.bmcl.2012.05.127
CHEMBL1817914 66495 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 452 16 0 0 9.8 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.bmcl.2012.05.127
CHEMBL1852172 66495 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 452 16 0 0 9.8 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.bmcl.2012.05.127
CHEMBL2057815 66495 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 452 16 0 0 9.8 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.bmcl.2012.05.127
56683103 66495 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 452 16 0 0 9.8 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.ejmech.2012.07.049
CHEMBL1817914 66495 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 452 16 0 0 9.8 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.ejmech.2012.07.049
CHEMBL1852172 66495 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 452 16 0 0 9.8 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.ejmech.2012.07.049
CHEMBL2057815 66495 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 452 16 0 0 9.8 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.ejmech.2012.07.049
56683103 66495 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 452 16 0 0 9.8 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.bmcl.2011.07.058
CHEMBL1817914 66495 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 452 16 0 0 9.8 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.bmcl.2011.07.058
CHEMBL1852172 66495 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 452 16 0 0 9.8 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.bmcl.2011.07.058
CHEMBL2057815 66495 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human CCR5 receptor expressed in MOLT4/CCR5 cells assessed as inhibition of CCL5-induced intracellular calcium mobilization by spectrophotometry
ChEMBL 452 16 0 0 9.8 CCCCCCCC/C=C\c1c(C)c(/C=C\CCCCCCCC)c2[n+](c1C)CCCCC2 10.1016/j.bmcl.2011.07.058
72713858 92754 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 538 8 1 6 4.9 Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccsc2)CC1 10.1021/jm401101p
CHEMBL2435910 92754 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 538 8 1 6 4.9 Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccsc2)CC1 10.1021/jm401101p
46225349 202506 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 539 6 0 5 4.3 Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C4CCCC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL595610 202506 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 539 6 0 5 4.3 Cc1cc(C#N)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CCN(C(=O)C4CCCC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
491775 12882 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assayAntagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL1188807 12882 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assayAntagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL537424 12882 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assayAntagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
21064329 14344 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 565 9 1 5 5.0 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(S(=O)(=O)c3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1171069 14344 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 565 9 1 5 5.0 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(S(=O)(=O)c3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1200059 14344 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 565 9 1 5 5.0 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(S(=O)(=O)c3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
46226122 14118 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 579 10 1 5 5.0 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(S(=O)(=O)c3ccccc3)c1)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL1198002 14118 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 579 10 1 5 5.0 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(S(=O)(=O)c3ccccc3)c1)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL592918 14118 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 579 10 1 5 5.0 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(S(=O)(=O)c3ccccc3)c1)CC2 10.1016/j.bmcl.2009.11.018
76310164 104645 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 586 10 1 4 5.0 CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCCc3ccc(Cl)cc3)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
CHEMBL3104690 104645 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 586 10 1 4 5.0 CC(=O)N1CCC(C(=O)N(CCCN2CCC(C(=O)NCCc3ccc(Cl)cc3)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
52945865 19079 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 838 13 1 6 7.9 C=CCN(C(=O)Cc1ccc(OC(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
CHEMBL1288920 19079 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
ChEMBL 838 13 1 6 7.9 C=CCN(C(=O)Cc1ccc(OC(F)(F)F)cc1)C1CCN(CCC2(c3cccc(F)c3)CCN(C(=O)c3cc(S(=O)(=O)NC(C)(C)C)c(F)cc3Cl)CC2)CC1 10.1016/j.bmcl.2010.10.033
21064283 14337 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assayAntagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay
ChEMBL 561 10 2 5 5.6 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL1170878 14337 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assayAntagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay
ChEMBL 561 10 2 5 5.6 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL1200019 14337 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assayAntagonist activity at human CCR5 expressed in HOS cells assessed as inhibition of cell fusion with HIV gp120 expressing HEK293 cells by LTR luciferase assay
ChEMBL 561 10 2 5 5.6 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)O)cc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
145984103 165966 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 541 7 1 7 4.3 CC(=O)N1CCN(C(=O)N[C@@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)c2ccc(C)s2)CC1 10.1021/acs.jmedchem.8b01077
CHEMBL4249241 165966 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 541 7 1 7 4.3 CC(=O)N1CCN(C(=O)N[C@@H](CCN2[C@H]3CC[C@@H]2C[C@@H](n2c(C)nnc2C(C)C)C3)c2ccc(C)s2)CC1 10.1021/acs.jmedchem.8b01077
9978318 122419 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Inhibition of 50% of RANTES co-receptor of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assayInhibition of 50% of RANTES co-receptor of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assay
ChEMBL 400 8 1 7 2.1 COc1ccc(/C=C/C(=O)OC(C)C(=O)[C@H]2C[C@@H]2[C@H](O)[C@H]2CC=CC(=O)O2)cc1 10.1016/j.bmcl.2004.08.021
CHEMBL359986 122419 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Inhibition of 50% of RANTES co-receptor of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assayInhibition of 50% of RANTES co-receptor of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assay
ChEMBL 400 8 1 7 2.1 COc1ccc(/C=C/C(=O)OC(C)C(=O)[C@H]2C[C@@H]2[C@H](O)[C@H]2CC=CC(=O)O2)cc1 10.1016/j.bmcl.2004.08.021
44395386 127605 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Inhibition of MIP-1alpha ligand of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assayInhibition of MIP-1alpha ligand of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assay
ChEMBL 400 8 1 7 2.1 COc1ccc(/C=C\C(=O)OC(C)C(=O)[C@H]2C[C@@H]2[C@H](O)[C@H]2CC=CC(=O)O2)cc1 10.1016/j.bmcl.2004.08.021
CHEMBL366260 127605 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Inhibition of MIP-1alpha ligand of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assayInhibition of MIP-1alpha ligand of chemokine receptor 5 induced calcium signal in U-87-CCR5 cells by calcium mobilization assay
ChEMBL 400 8 1 7 2.1 COc1ccc(/C=C\C(=O)OC(C)C(=O)[C@H]2C[C@@H]2[C@H](O)[C@H]2CC=CC(=O)O2)cc1 10.1016/j.bmcl.2004.08.021
73349500 92826 None 0 Human Functional pIC50 = 4.1 4.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 487 8 2 6 4.9 CC(=O)Nc1ccc(CN2CCC(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 10.1016/j.ejmech.2013.09.004
CHEMBL2436718 92826 None 0 Human Functional pIC50 = 4.1 4.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 487 8 2 6 4.9 CC(=O)Nc1ccc(CN2CCC(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 10.1016/j.ejmech.2013.09.004
50993436 57216 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 421 6 2 5 3.3 CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CNCC3)C2)c1ccccc1 10.1021/jm100978n
CHEMBL1649915 57216 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
ChEMBL 421 6 2 5 3.3 CC(=O)N[C@@H](CCN1[C@H]2CC[C@@H]1C[C@H](n1c(C)nc3c1CNCC3)C2)c1ccccc1 10.1021/jm100978n
3008936 201152 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 484 5 0 4 4.8 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
CHEMBL58109 201152 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 484 5 0 4 4.8 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1021/jm031046g
126567306 165772 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 519 8 1 6 6.0 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cccs1 10.1021/acs.jmedchem.8b01077
CHEMBL4244935 165772 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 519 8 1 6 6.0 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1cccs1 10.1021/acs.jmedchem.8b01077
122668196 192070 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 501 8 1 6 5.9 Cc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCCCC1)c1ccc(F)s1 10.1021/acs.jmedchem.2c01383
CHEMBL5200961 192070 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as intracellular calcium change incubated for 15 mins by Fluo-4 AM calcium flux assay
ChEMBL 501 8 1 6 5.9 Cc1nnc(C(C)C)n1[C@@H]1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCCCC1)c1ccc(F)s1 10.1021/acs.jmedchem.2c01383
145985894 165502 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 569 8 1 6 7.2 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1csc2ccccc12 10.1021/acs.jmedchem.8b01077
CHEMBL4238266 165502 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assayAntagonist activity at CCR5 (unknown origin) expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of RANTES-induced calcium flux preincubated for 10 mins followed by RANTES addition by fluo-4AM-based fluorescence assay
ChEMBL 569 8 1 6 7.2 Cc1nnc(C(C)C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1csc2ccccc12 10.1021/acs.jmedchem.8b01077
5275763 96844 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 622 10 1 5 4.7 CNC(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(S(C)(=O)=O)CC3)c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1021/jm051034q
CHEMBL264832 96844 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
ChEMBL 622 10 1 5 4.7 CNC(=O)c1ccc(CC2CCN(CCCN(C(=O)C3CCN(S(C)(=O)=O)CC3)c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1021/jm051034q
3008925 100968 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 492 5 1 3 6.5 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2cccc3[nH]ccc23)CC1 10.1021/jm031046g
CHEMBL293900 100968 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 492 5 1 3 6.5 CC1(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CCN(C(=O)c2cccc3[nH]ccc23)CC1 10.1021/jm031046g
57401041 69224 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 568 10 1 6 5.9 COC(=O)c1ccc(N(Cc2ccccc2)C2CCN(C(C)CCNC(=O)c3c(Cl)cncc3Cl)CC2)cc1 10.1016/j.bmcl.2011.09.133
CHEMBL1926876 69224 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 568 10 1 6 5.9 COC(=O)c1ccc(N(Cc2ccccc2)C2CCN(C(C)CCNC(=O)c3c(Cl)cncc3Cl)CC2)cc1 10.1016/j.bmcl.2011.09.133
10159218 13940 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 385 7 1 3 3.2 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccccc1)CC2 10.1021/jm060051s
CHEMBL1196504 13940 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 385 7 1 3 3.2 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccccc1)CC2 10.1021/jm060051s
CHEMBL557199 13940 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationAntagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilization
ChEMBL 385 7 1 3 3.2 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccccc1)CC2 10.1021/jm060051s
10159218 13940 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 385 7 1 3 3.2 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccccc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1196504 13940 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 385 7 1 3 3.2 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccccc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL557199 13940 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 385 7 1 3 3.2 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccccc1)CC2 10.1016/j.bmc.2010.05.057
10159218 13940 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 385 7 1 3 3.2 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccccc1)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL1196504 13940 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 385 7 1 3 3.2 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccccc1)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL557199 13940 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 385 7 1 3 3.2 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccccc1)CC2 10.1016/j.bmcl.2009.11.018
73351055 92827 None 0 Human Functional pIC50 = 4.1 4.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 471 9 1 4 6.2 CCN(CC)c1ccc(CN2CCC(c3ccc(OC)c(NC(=O)c4ccccc4)c3)CC2)cc1 10.1016/j.ejmech.2013.09.004
CHEMBL2436719 92827 None 0 Human Functional pIC50 = 4.1 4.1 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 471 9 1 4 6.2 CCN(CC)c1ccc(CN2CCC(c3ccc(OC)c(NC(=O)c4ccccc4)c3)CC2)cc1 10.1016/j.ejmech.2013.09.004
118727187 117455 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 542 8 0 4 5.0 CC(=O)N1CCC(C(=O)N(CCCN2CCCN(Cc3ccc(F)cc3)CC2)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
CHEMBL3397998 117455 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
ChEMBL 542 8 0 4 5.0 CC(=O)N1CCC(C(=O)N(CCCN2CCCN(Cc3ccc(F)cc3)CC2)c2ccc(C)c(Cl)c2)CC1 10.1016/j.bmc.2014.12.052
72712374 92718 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 457 5 1 3 5.3 O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc3nc[nH]c3c2)CC1 10.1021/jm401101p
CHEMBL2435874 92718 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 457 5 1 3 5.3 O=C1N(C2CCCCC2)C[C@@H](c2ccccc2)N1C1CCN(Cc2ccc3nc[nH]c3c2)CC1 10.1021/jm401101p
72714318 92732 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 550 8 1 5 5.0 Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccccc2F)CC1 10.1021/jm401101p
CHEMBL2435888 92732 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
ChEMBL 550 8 1 5 5.0 Cc1ncnc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccccc2F)CC1 10.1021/jm401101p
3008912 203529 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 458 4 1 4 5.4 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc4ccn(C)c4c3)CC2)CC1 10.1021/jm031046g
CHEMBL60279 203529 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
ChEMBL 458 4 1 4 5.4 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Nc3ccc4ccn(C)c4c3)CC2)CC1 10.1021/jm031046g
23577378 66453 None 0 Human Functional pIC50 = 4.0 4.0 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 563 10 2 6 4.9 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(OC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1813269 66453 None 0 Human Functional pIC50 = 4.0 4.0 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 563 10 2 6 4.9 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(OC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
CHEMBL1851957 66453 None 0 Human Functional pIC50 = 4.0 4.0 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization
ChEMBL 563 10 2 6 4.9 CCCCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(OC)cc3)cc1)CC2 10.1016/j.bmc.2011.05.022
21064289 14407 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 535 9 1 4 6.1 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(F)cc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1173647 14407 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 535 9 1 4 6.1 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(F)cc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1200295 14407 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 535 9 1 4 6.1 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(F)cc3)cc1)CC2 10.1016/j.bmc.2010.05.057
46226130 14120 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 549 10 1 4 6.1 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(F)cc3)c1)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL1198009 14120 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 549 10 1 4 6.1 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(F)cc3)c1)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL593111 14120 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 549 10 1 4 6.1 CCCCN1C(=O)[C@H](CC2CCCCC2)NC(=O)C12CCN(CCc1cccc(Oc3ccc(F)cc3)c1)CC2 10.1016/j.bmcl.2009.11.018
46225527 202150 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 571 6 0 6 3.3 Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCOC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL593184 202150 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 571 6 0 6 3.3 Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CCOC4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
62707282 77205 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 286 8 0 0 5.3 CCCCCCCC/C=C\c1c(C)cc(C)[n+]2c1CCC2 10.1016/j.bmcl.2012.05.127
CHEMBL2057534 77205 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 286 8 0 0 5.3 CCCCCCCC/C=C\c1c(C)cc(C)[n+]2c1CCC2 10.1016/j.bmcl.2012.05.127
CHEMBL2078850 77205 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 286 8 0 0 5.3 CCCCCCCC/C=C\c1c(C)cc(C)[n+]2c1CCC2 10.1016/j.bmcl.2012.05.127
54752875 77219 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c(C)[n+]2c1CCC2 10.1016/j.bmcl.2012.05.127
CHEMBL2057813 77219 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c(C)[n+]2c1CCC2 10.1016/j.bmcl.2012.05.127
CHEMBL2079028 77219 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM stainingAntagonist activity at CCR5 receptor expressed in human MOLT4 cells assessed as inhibition of CCl5-induced calcium mobilization after 1 hr by Fluor-4-AM staining
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c(C)[n+]2c1CCC2 10.1016/j.bmcl.2012.05.127
62707282 77205 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 286 8 0 0 5.3 CCCCCCCC/C=C\c1c(C)cc(C)[n+]2c1CCC2 10.1016/j.ejmech.2012.07.049
CHEMBL2057534 77205 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 286 8 0 0 5.3 CCCCCCCC/C=C\c1c(C)cc(C)[n+]2c1CCC2 10.1016/j.ejmech.2012.07.049
CHEMBL2078850 77205 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 286 8 0 0 5.3 CCCCCCCC/C=C\c1c(C)cc(C)[n+]2c1CCC2 10.1016/j.ejmech.2012.07.049
54752875 77219 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c(C)[n+]2c1CCC2 10.1016/j.ejmech.2012.07.049
CHEMBL2057813 77219 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c(C)[n+]2c1CCC2 10.1016/j.ejmech.2012.07.049
CHEMBL2079028 77219 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 424 16 0 0 9.1 CCCCCCCC/C=C\c1c(C)c(/C=C/CCCCCCCC)c(C)[n+]2c1CCC2 10.1016/j.ejmech.2012.07.049
70692903 77236 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 286 8 0 0 5.3 CCCCCCCC/C=C/c1c(C)cc(C)[n+]2c1CCC2 10.1016/j.ejmech.2012.07.049
CHEMBL2064265 77236 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 286 8 0 0 5.3 CCCCCCCC/C=C/c1c(C)cc(C)[n+]2c1CCC2 10.1016/j.ejmech.2012.07.049
CHEMBL2079297 77236 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assayAntagonist activity at CCR5 receptor in human MOLT4 cells assessed as inhibition of chemokine-induced calcium mobilization using Fluo-4-AM dye based fluorometric assay
ChEMBL 286 8 0 0 5.3 CCCCCCCC/C=C/c1c(C)cc(C)[n+]2c1CCC2 10.1016/j.ejmech.2012.07.049
73352528 92822 None 0 Human Functional pIC50 = 4.0 4.0 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 485 8 2 4 6.1 CC(=O)Nc1ccc(CN2CCC(c3ccc(OC(C)C)c(NC(=O)c4ccccc4)c3)CC2)cc1 10.1016/j.ejmech.2013.09.004
CHEMBL2436714 92822 None 0 Human Functional pIC50 = 4.0 4.0 - 1
Antagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader methodAntagonist activity at CCR5 (unknown origin) expressed in MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium ion mobilization after 15 mins by microplate reader method
ChEMBL 485 8 2 4 6.1 CC(=O)Nc1ccc(CN2CCC(c3ccc(OC(C)C)c(NC(=O)c4ccccc4)c3)CC2)cc1 10.1016/j.ejmech.2013.09.004
46225526 202189 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 523 6 0 5 3.3 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
CHEMBL593520 202189 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
ChEMBL 523 6 0 5 3.3 Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC3(c4ccccc4)CN(C(=O)C4CC(F)(F)C4)C3)C[C@@H]2C1 10.1016/j.bmcl.2009.11.072
57331306 104636 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 600 10 0 4 5.7 CCN(Cc1ccc(Cl)cc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
CHEMBL3104679 104636 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Inhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assayInhibition of CCR5 (unknown origin) expressed in CHO cells assessed as inhibition of RANTES-induced intracellular Ca2+ mobilization after 10 mins by Fluo-4 AM staining-based fluorescence assay
ChEMBL 600 10 0 4 5.7 CCN(Cc1ccc(Cl)cc1)C(=O)C1CCN(CCCN(C(=O)C2CCN(C(C)=O)CC2)c2cccc(Cl)c2)CC1 10.1016/j.ejmech.2013.11.013
491775 12882 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
CHEMBL1188807 12882 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
CHEMBL537424 12882 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilizationAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1-alpha-stimulated calcium mobilization
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2006.10.084
491775 12882 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL1188807 12882 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
CHEMBL537424 12882 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assayAntagonist activity at human CCR5 expressed in CHO cells assessed as inhibition of MIP-1alpha-induced calcium mobilization Ca assay
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2010.12.109
491775 12882 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL1188807 12882 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
CHEMBL537424 12882 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilizationAntagonist activity at human CCR5 receptor expressed in CHO cells assessed as inhibition of MIP-1-alpha-stmulated calcium mobilization
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmc.2010.05.057
491775 12882 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL1188807 12882 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2009.11.018
CHEMBL537424 12882 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilizationAntagonist activity at human CCR5 receptor overexpressed in CHO cells assessed as inhibition of MIP-1-alpha-induced calcium mobilization
ChEMBL 477 9 1 4 5.0 CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(Cc1ccc(Oc3ccccc3)cc1)CC2 10.1016/j.bmcl.2009.11.018
162677463 183682 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysisAntagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysis
ChEMBL 857 23 5 11 4.1 CNC(=O)COCC(=O)NCCCCCNC(=O)COCC(=O)Nc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)cc1 10.1016/j.bmc.2016.09.059
CHEMBL4800480 183682 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Antagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysisAntagonist activity at CCR5 receptor in human MOLT4 cells transfected with Gqi5 assessed as inhibition of RANTES-induced calcium mobilization incubated for 15 mins prior to RANTES addition and measured for 120 secs by Fluo-4AM dye based fluorescence analysis
ChEMBL 857 23 5 11 4.1 CNC(=O)COCC(=O)NCCCCCNC(=O)COCC(=O)Nc1ccc([C@H](CCN2[C@H]3CC[C@@H]2C[C@H](n2c(C)nnc2C(C)C)C3)NC(=O)C2CCC(F)(F)CC2)cc1 10.1016/j.bmc.2016.09.059
CHEMBL5089300 217691 None 0 Human Functional pIC50 = 6.0 6.0 -13 2
Antagonist activity at CCR5 (unknown origin) expressed in HOS cells co-expressing Gqi-5 assessed as inhibition CCL5-stimulated Ca2+ mobilization by calcium mobilization assayAntagonist activity at CCR5 (unknown origin) expressed in HOS cells co-expressing Gqi-5 assessed as inhibition CCL5-stimulated Ca2+ mobilization by calcium mobilization assay
ChEMBL None None None CC(C)c1nnc(CCNC(=O)COCC(=O)NCCCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)n1C1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1 10.1021/acs.jmedchem.1c00408
90656334 111133 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 489 8 1 8 3.6 COC(=O)c1ccc(CN2CCN(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 10.1016/j.bmcl.2014.03.073
CHEMBL3263030 111133 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in human MOLT4 cells assessed as inhibition of RANTES-stimulated calcium mobilization treated for 15 mins prior to RANTES addition by spectrophotometric analysis
ChEMBL 489 8 1 8 3.6 COC(=O)c1ccc(CN2CCN(c3ccc(OC(C)C)c(NC(=O)c4cnccn4)c3)CC2)cc1 10.1016/j.bmcl.2014.03.073
23577328 66455 None 0 Human Functional pIC50 = 4.0 4.0 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 592 10 3 7 3.1 CNC(=O)c1ccc(Oc2ccc(CN3CCC4(CC3)C(=O)N[C@H]([C@H](O)C3CCCCC3)C(=O)N4CCOC)cc2)cc1 10.1016/j.bmc.2011.05.022
CHEMBL1813454 66455 None 0 Human Functional pIC50 = 4.0 4.0 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 592 10 3 7 3.1 CNC(=O)c1ccc(Oc2ccc(CN3CCC4(CC3)C(=O)N[C@H]([C@H](O)C3CCCCC3)C(=O)N4CCOC)cc2)cc1 10.1016/j.bmc.2011.05.022
CHEMBL1851967 66455 None 0 Human Functional pIC50 = 4.0 4.0 - 1
Antagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assayAntagonist activity against human CCR5 receptor assessed as inhibition of HIV1 gp120-induced cell-cell fusion between viral envolop protein expressing human HEK293 cells to human CD4/CCR5 receptor expressing HOS cells after 24 hrs by luciferase reporter gene assay
ChEMBL 592 10 3 7 3.1 CNC(=O)c1ccc(Oc2ccc(CN3CCC4(CC3)C(=O)N[C@H]([C@H](O)C3CCCCC3)C(=O)N4CCOC)cc2)cc1 10.1016/j.bmc.2011.05.022
60196353 81654 None 0 Human Functional pKd = 8.8 8.8 - 0
Antagonist activity at human CCR5 expressed in HEK 293 Glosensor cells assessed as reduction in RANTES-induced intracellular calcium levels preincubated for 30 mins followed by RANTES addition measured at 2 secs time interval for 5 mins by Fluo-4-AM dye based fluorescence assayAntagonist activity at human CCR5 expressed in HEK 293 Glosensor cells assessed as reduction in RANTES-induced intracellular calcium levels preincubated for 30 mins followed by RANTES addition measured at 2 secs time interval for 5 mins by Fluo-4-AM dye based fluorescence assay
ChEMBL 513 8 1 5 6.0 Cc1nnc(C(C)C)n1C1C[C@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1 10.1021/acs.jmedchem.6b01801
CHEMBL2163486 81654 None 0 Human Functional pKd = 8.8 8.8 - 0
Antagonist activity at human CCR5 expressed in HEK 293 Glosensor cells assessed as reduction in RANTES-induced intracellular calcium levels preincubated for 30 mins followed by RANTES addition measured at 2 secs time interval for 5 mins by Fluo-4-AM dye based fluorescence assayAntagonist activity at human CCR5 expressed in HEK 293 Glosensor cells assessed as reduction in RANTES-induced intracellular calcium levels preincubated for 30 mins followed by RANTES addition measured at 2 secs time interval for 5 mins by Fluo-4-AM dye based fluorescence assay
ChEMBL 513 8 1 5 6.0 Cc1nnc(C(C)C)n1C1C[C@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1 10.1021/acs.jmedchem.6b01801
137643501 158485 None 0 Human Functional pKd = 8 8.0 - 0
Antagonist activity at human CCR5 expressed in HEK 293 Glosensor cells assessed as reduction in RANTES-induced intracellular calcium levels preincubated for 30 mins followed by RANTES addition measured at 2 secs time interval for 5 mins by Fluo-4-AM dye based fluorescence assayAntagonist activity at human CCR5 expressed in HEK 293 Glosensor cells assessed as reduction in RANTES-induced intracellular calcium levels preincubated for 30 mins followed by RANTES addition measured at 2 secs time interval for 5 mins by Fluo-4-AM dye based fluorescence assay
ChEMBL 471 6 1 5 4.5 Cc1nnc2n1[C@@H]1CCN(CC[C@H](NC(=O)C3CCC(F)(F)CC3)c3ccccc3)C[C@@H]1CC2 10.1021/acs.jmedchem.6b01801
CHEMBL4089991 158485 None 0 Human Functional pKd = 8 8.0 - 0
Antagonist activity at human CCR5 expressed in HEK 293 Glosensor cells assessed as reduction in RANTES-induced intracellular calcium levels preincubated for 30 mins followed by RANTES addition measured at 2 secs time interval for 5 mins by Fluo-4-AM dye based fluorescence assayAntagonist activity at human CCR5 expressed in HEK 293 Glosensor cells assessed as reduction in RANTES-induced intracellular calcium levels preincubated for 30 mins followed by RANTES addition measured at 2 secs time interval for 5 mins by Fluo-4-AM dye based fluorescence assay
ChEMBL 471 6 1 5 4.5 Cc1nnc2n1[C@@H]1CCN(CC[C@H](NC(=O)C3CCC(F)(F)CC3)c3ccccc3)C[C@@H]1CC2 10.1021/acs.jmedchem.6b01801
137631641 156700 None 0 Human Functional pKd = 6.5 6.5 - 0
Antagonist activity at human CCR5 expressed in HEK 293 Glosensor cells assessed as reduction in RANTES-induced intracellular calcium levels preincubated for 30 mins followed by RANTES addition measured at 2 secs time interval for 5 mins by Fluo-4-AM dye based fluorescence assayAntagonist activity at human CCR5 expressed in HEK 293 Glosensor cells assessed as reduction in RANTES-induced intracellular calcium levels preincubated for 30 mins followed by RANTES addition measured at 2 secs time interval for 5 mins by Fluo-4-AM dye based fluorescence assay
ChEMBL 471 6 1 5 4.5 Cc1nnc2n1[C@H]1CCN(CC[C@H](NC(=O)C3CCC(F)(F)CC3)c3ccccc3)C[C@H]1CC2 10.1021/acs.jmedchem.6b01801
CHEMBL4068906 156700 None 0 Human Functional pKd = 6.5 6.5 - 0
Antagonist activity at human CCR5 expressed in HEK 293 Glosensor cells assessed as reduction in RANTES-induced intracellular calcium levels preincubated for 30 mins followed by RANTES addition measured at 2 secs time interval for 5 mins by Fluo-4-AM dye based fluorescence assayAntagonist activity at human CCR5 expressed in HEK 293 Glosensor cells assessed as reduction in RANTES-induced intracellular calcium levels preincubated for 30 mins followed by RANTES addition measured at 2 secs time interval for 5 mins by Fluo-4-AM dye based fluorescence assay
ChEMBL 471 6 1 5 4.5 Cc1nnc2n1[C@H]1CCN(CC[C@H](NC(=O)C3CCC(F)(F)CC3)c3ccccc3)C[C@H]1CC2 10.1021/acs.jmedchem.6b01801
3009353 168128 None 0 Human Functional pKi = 9.0 9.0 - 0
Antagonistic activity against C-C chemokine receptor type 5Antagonistic activity against C-C chemokine receptor type 5
ChEMBL 531 6 0 5 5.7 CCC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C 10.1021/jm0304515
CHEMBL432170 168128 None 0 Human Functional pKi = 9.0 9.0 - 0
Antagonistic activity against C-C chemokine receptor type 5Antagonistic activity against C-C chemokine receptor type 5
ChEMBL 531 6 0 5 5.7 CCC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C 10.1021/jm0304515
3009354 207734 None 0 Human Functional pKi = 8.9 8.9 - 0
Antagonistic activity against C-C chemokine receptor type 5Antagonistic activity against C-C chemokine receptor type 5
ChEMBL 579 6 0 5 6.1 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](Cc3ccccc3)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1 10.1021/jm0304515
CHEMBL79061 207734 None 0 Human Functional pKi = 8.9 8.9 - 0
Antagonistic activity against C-C chemokine receptor type 5Antagonistic activity against C-C chemokine receptor type 5
ChEMBL 579 6 0 5 6.1 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](Cc3ccccc3)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1 10.1021/jm0304515
3009356 105679 None 0 Human Functional pKi = 8.8 8.8 - 0
Antagonistic activity against C-C chemokine receptor type 5Antagonistic activity against C-C chemokine receptor type 5
ChEMBL 543 6 0 5 5.7 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](CC3CC3)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1 10.1021/jm0304515
CHEMBL312344 105679 None 0 Human Functional pKi = 8.8 8.8 - 0
Antagonistic activity against C-C chemokine receptor type 5Antagonistic activity against C-C chemokine receptor type 5
ChEMBL 543 6 0 5 5.7 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](CC3CC3)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1 10.1021/jm0304515
3009355 3989 None 18 Human Functional pKi = 8.6 8.6 -1 2
Antagonistic activity against C-C chemokine receptor type 5Antagonistic activity against C-C chemokine receptor type 5
ChEMBL 533 6 0 6 4.5 COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F 10.1021/jm0304515
807 3989 None 18 Human Functional pKi = 8.6 8.6 -1 2
Antagonistic activity against C-C chemokine receptor type 5Antagonistic activity against C-C chemokine receptor type 5
ChEMBL 533 6 0 6 4.5 COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F 10.1021/jm0304515
CHEMBL82301 3989 None 18 Human Functional pKi = 8.6 8.6 -1 2
Antagonistic activity against C-C chemokine receptor type 5Antagonistic activity against C-C chemokine receptor type 5
ChEMBL 533 6 0 6 4.5 COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F 10.1021/jm0304515
DB06652 3989 None 18 Human Functional pKi = 8.6 8.6 -1 2
Antagonistic activity against C-C chemokine receptor type 5Antagonistic activity against C-C chemokine receptor type 5
ChEMBL 533 6 0 6 4.5 COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F 10.1021/jm0304515
483747 105465 None 1 Human Functional pKi = 8.6 8.6 - 1
Antagonistic activity against C-C chemokine receptor type 5Antagonistic activity against C-C chemokine receptor type 5
ChEMBL 503 4 0 5 4.9 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1 10.1021/jm0304515
CHEMBL311795 105465 None 1 Human Functional pKi = 8.6 8.6 - 1
Antagonistic activity against C-C chemokine receptor type 5Antagonistic activity against C-C chemokine receptor type 5
ChEMBL 503 4 0 5 4.9 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1 10.1021/jm0304515
10436045 3516 None 4 Human Functional pKi = 5.4 5.4 - 1
Compound was evaluated for the antagonist activity against C-C chemokine receptor type 5Compound was evaluated for the antagonist activity against C-C chemokine receptor type 5
ChEMBL 499 9 3 3 6.4 O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 10.1016/s0960-894x(00)00347-4
782 3516 None 4 Human Functional pKi = 5.4 5.4 - 1
Compound was evaluated for the antagonist activity against C-C chemokine receptor type 5Compound was evaluated for the antagonist activity against C-C chemokine receptor type 5
ChEMBL 499 9 3 3 6.4 O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 10.1016/s0960-894x(00)00347-4
CHEMBL432713 3516 None 4 Human Functional pKi = 5.4 5.4 - 1
Compound was evaluated for the antagonist activity against C-C chemokine receptor type 5Compound was evaluated for the antagonist activity against C-C chemokine receptor type 5
ChEMBL 499 9 3 3 6.4 O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 10.1016/s0960-894x(00)00347-4
3009352 96692 None 0 Human Functional pKi = 8.3 8.3 - 0
Antagonistic activity against C-C chemokine receptor type 5Antagonistic activity against C-C chemokine receptor type 5
ChEMBL 517 5 0 5 5.3 CC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C 10.1021/jm0304515
CHEMBL263555 96692 None 0 Human Functional pKi = 8.3 8.3 - 0
Antagonistic activity against C-C chemokine receptor type 5Antagonistic activity against C-C chemokine receptor type 5
ChEMBL 517 5 0 5 5.3 CC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C 10.1021/jm0304515
15664 83821 None 63 Human Functional pEC50 = 8.3 8.3 2 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
Drug Central 184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1 None
CHEMBL2205807 83821 None 63 Human Functional pEC50 = 8.3 8.3 2 3
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
Drug Central 184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1 None
10585 1079 None 1 Human Functional pIC50 = 7.1 7.1 -1 2
Antagonist effect on CCL3-induced β-arrestin recruitment in U2OS cells stably expressing human CCR5.Antagonist effect on CCL3-induced β-arrestin recruitment in U2OS cells stably expressing human CCR5.
Guide to Pharmacology 351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C 31742400
145996522 1079 None 1 Human Functional pIC50 = 7.1 7.1 -1 2
Antagonist effect on CCL3-induced β-arrestin recruitment in U2OS cells stably expressing human CCR5.Antagonist effect on CCL3-induced β-arrestin recruitment in U2OS cells stably expressing human CCR5.
Guide to Pharmacology 351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C 31742400
CHEMBL4531005 1079 None 1 Human Functional pIC50 = 7.1 7.1 -1 2
Antagonist effect on CCL3-induced β-arrestin recruitment in U2OS cells stably expressing human CCR5.Antagonist effect on CCL3-induced β-arrestin recruitment in U2OS cells stably expressing human CCR5.
Guide to Pharmacology 351 3 2 5 3.0 Nc1nn2c(n1)[nH]c(c(c2=O)Cc1cccc(c1Cl)Cl)C(C)C 31742400
10106 873 None 0 Human Functional pIC50 = 8.5 8.5 - 1
In a whole cell intracellular calcium mobilisation assay using HEK293 cells expressing hCCR5.In a whole cell intracellular calcium mobilisation assay using HEK293 cells expressing hCCR5.
Guide to Pharmacology 519 8 1 6 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccsc1)CCN1[C@@H]2CC[C@H]1C[C@@H](C2)n1c(C)nnc1C(C)C 30234300
91820689 873 None 0 Human Functional pIC50 = 8.5 8.5 - 1
In a whole cell intracellular calcium mobilisation assay using HEK293 cells expressing hCCR5.In a whole cell intracellular calcium mobilisation assay using HEK293 cells expressing hCCR5.
Guide to Pharmacology 519 8 1 6 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccsc1)CCN1[C@@H]2CC[C@H]1C[C@@H](C2)n1c(C)nnc1C(C)C 30234300
CHEMBL4249798 873 None 0 Human Functional pIC50 = 8.5 8.5 - 1
In a whole cell intracellular calcium mobilisation assay using HEK293 cells expressing hCCR5.In a whole cell intracellular calcium mobilisation assay using HEK293 cells expressing hCCR5.
Guide to Pharmacology 519 8 1 6 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccsc1)CCN1[C@@H]2CC[C@H]1C[C@@H](C2)n1c(C)nnc1C(C)C 30234300
10750 2579 None 0 Human Functional pIC50 = 5.4 5.4 -5011 2
UnclassifiedUnclassified
Guide to Pharmacology 532 5 2 5 6.3 Clc1ccc(cc1)C1(O)CCN(CC1(C)C)CC/C=C\1/c2cc(ccc2OCc2c1cccn2)C(O)(C)C 17715391
18437138 2579 None 0 Human Functional pIC50 = 5.4 5.4 -5011 2
UnclassifiedUnclassified
Guide to Pharmacology 532 5 2 5 6.3 Clc1ccc(cc1)C1(O)CCN(CC1(C)C)CC/C=C\1/c2cc(ccc2OCc2c1cccn2)C(O)(C)C 17715391
11597 674 None 6 Human Functional pIC50 = 7.1 7.1 -11 2
UnclassifiedUnclassified
Guide to Pharmacology 506 5 3 6 3.5 CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C 34141082
23725180 674 None 6 Human Functional pIC50 = 7.1 7.1 -11 2
UnclassifiedUnclassified
Guide to Pharmacology 506 5 3 6 3.5 CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C 34141082
CHEMBL4781426 674 None 6 Human Functional pIC50 = 7.1 7.1 -11 2
UnclassifiedUnclassified
Guide to Pharmacology 506 5 3 6 3.5 CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)NC(C)(C)C 34141082
769 827 None 0 Human Functional pIC50 = 7.7 7.7 -14 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10477718
3002977 2460 None 43 Human Functional pIC50 = 8.1 8.1 2 4
UnclassifiedUnclassified
Guide to Pharmacology 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 16298345
3002977.0 2460 None 43 Human Functional pIC50 = 8.1 8.1 2 4
UnclassifiedUnclassified
Guide to Pharmacology 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 16298345
803 2460 None 43 Human Functional pIC50 = 8.1 8.1 2 4
UnclassifiedUnclassified
Guide to Pharmacology 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 16298345
806 2460 None 43 Human Functional pIC50 = 8.1 8.1 2 4
UnclassifiedUnclassified
Guide to Pharmacology 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 16298345
CHEMBL1201187 2460 None 43 Human Functional pIC50 = 8.1 8.1 2 4
UnclassifiedUnclassified
Guide to Pharmacology 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 16298345
CHEMBL256907 2460 None 43 Human Functional pIC50 = 8.1 8.1 2 4
UnclassifiedUnclassified
Guide to Pharmacology 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 16298345
CHEMBL584744 2460 None 43 Human Functional pIC50 = 8.1 8.1 2 4
UnclassifiedUnclassified
Guide to Pharmacology 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 16298345
DB04835 2460 None 43 Human Functional pIC50 = 8.1 8.1 2 4
UnclassifiedUnclassified
Guide to Pharmacology 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 16298345
486830 4002 None 0 Human Functional pIC50 = 8.3 8.3 -6 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9287217
768 4002 None 0 Human Functional pIC50 = 8.3 8.3 -6 5
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9287217
68764898 672 None 2 Human Functional pIC50 = 8.6 8.6 -3 2
UnclassifiedUnclassified
Guide to Pharmacology 491 7 1 5 5.3 CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C 25893046
9430 672 None 2 Human Functional pIC50 = 8.6 8.6 -3 2
UnclassifiedUnclassified
Guide to Pharmacology 491 7 1 5 5.3 CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C 25893046
CHEMBL3577945 672 None 2 Human Functional pIC50 = 8.6 8.6 -3 2
UnclassifiedUnclassified
Guide to Pharmacology 491 7 1 5 5.3 CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C 25893046
3500 1526 None 13 Human Functional pIC50 = 8.7 8.7 245 2
UnclassifiedUnclassified
Guide to Pharmacology 483 7 1 5 3.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C21CCN(CC2)Cc1ccc2c(c1)OCCO2 11454872
491774 1526 None 13 Human Functional pIC50 = 8.7 8.7 245 2
UnclassifiedUnclassified
Guide to Pharmacology 483 7 1 5 3.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C21CCN(CC2)Cc1ccc2c(c1)OCCO2 11454872
CHEMBL1196395 1526 None 13 Human Functional pIC50 = 8.7 8.7 245 2
UnclassifiedUnclassified
Guide to Pharmacology 483 7 1 5 3.9 CCCCN1C(=O)C(CC2CCCCC2)NC(=O)C21CCN(CC2)Cc1ccc2c(c1)OCCO2 11454872
5275766 3738 None 34 Human Functional pIC50 None 8.5 8.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology 552 9 1 4 4.7 CC(=O)N1CCC(CC1)C(=O)N(c1ccc(c(c1)Cl)C)CCCN1CCC(CC1)Cc1ccc(cc1)C(=O)N 16640339
800 3738 None 34 Human Functional pIC50 None 8.5 8.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology 552 9 1 4 4.7 CC(=O)N1CCC(CC1)C(=O)N(c1ccc(c(c1)Cl)C)CCCN1CCC(CC1)Cc1ccc(cc1)C(=O)N 16640339
CHEMBL207004 3738 None 34 Human Functional pIC50 None 8.5 8.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology 552 9 1 4 4.7 CC(=O)N1CCC(CC1)C(=O)N(c1ccc(c(c1)Cl)C)CCCN1CCC(CC1)Cc1ccc(cc1)C(=O)N 16640339
11285792 879 None 32 Human Functional pIC50 None 8.6 8.6 -3 6
UnclassifiedUnclassified
Guide to Pharmacology 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 16251299
801 879 None 32 Human Functional pIC50 None 8.6 8.6 -3 6
UnclassifiedUnclassified
Guide to Pharmacology 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 16251299
CHEMBL2110727 879 None 32 Human Functional pIC50 None 8.6 8.6 -3 6
UnclassifiedUnclassified
Guide to Pharmacology 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 16251299
DB11758 879 None 32 Human Functional pIC50 None 8.6 8.6 -3 6
UnclassifiedUnclassified
Guide to Pharmacology 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 16251299




Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
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DOI

CHEMBL2372983 212790 None 0 Human Binding pEC50 = 9.7 9.7 - 0
Effective concentration for antagonistic activity by inhibition of T-tropic strain of HIV-1 through its specific binding to a chemokine receptorEffective concentration for antagonistic activity by inhibition of T-tropic strain of HIV-1 through its specific binding to a chemokine receptor
ChEMBL None None None NCCCC[C@@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C1=O 10.1016/s0960-894x(00)00664-8
3002977 2460 None 43 Human Binding pEC50 = 9 9.0 -1 2
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1039/C6MD00311G
3002977.0 2460 None 43 Human Binding pEC50 = 9 9.0 -1 2
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1039/C6MD00311G
803 2460 None 43 Human Binding pEC50 = 9 9.0 -1 2
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1039/C6MD00311G
806 2460 None 43 Human Binding pEC50 = 9 9.0 -1 2
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1039/C6MD00311G
CHEMBL1201187 2460 None 43 Human Binding pEC50 = 9 9.0 -1 2
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1039/C6MD00311G
CHEMBL256907 2460 None 43 Human Binding pEC50 = 9 9.0 -1 2
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1039/C6MD00311G
CHEMBL584744 2460 None 43 Human Binding pEC50 = 9 9.0 -1 2
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1039/C6MD00311G
DB04835 2460 None 43 Human Binding pEC50 = 9 9.0 -1 2
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1039/C6MD00311G
129908110 156046 None 0 Human Binding pEC50 = 5.0 5.0 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 485 9 1 6 5.3 CC(=O)Oc1ccc(/C=C/C(=O)CCc2ccc(NC(=O)c3ccc(C)cc3)cc2)cc1OC(C)=O 10.1039/C6MD00311G
CHEMBL4061273 156046 None 0 Human Binding pEC50 = 5.0 5.0 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 485 9 1 6 5.3 CC(=O)Oc1ccc(/C=C/C(=O)CCc2ccc(NC(=O)c3ccc(C)cc3)cc2)cc1OC(C)=O 10.1039/C6MD00311G
129908195 158881 None 0 Human Binding pEC50 = 4.8 4.8 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 493 11 1 7 4.9 CC(=O)Oc1ccc(CCC(=O)CCc2ccc(NC(=O)Cc3cccs3)cc2)cc1OC(C)=O 10.1039/C6MD00311G
CHEMBL4094196 158881 None 0 Human Binding pEC50 = 4.8 4.8 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 493 11 1 7 4.9 CC(=O)Oc1ccc(CCC(=O)CCc2ccc(NC(=O)Cc3cccs3)cc2)cc1OC(C)=O 10.1039/C6MD00311G
129908301 156790 None 0 Human Binding pEC50 = 4.8 4.8 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 516 10 1 8 4.9 CC(=O)Oc1ccc(/C=C/C(=O)CCc2ccc(NC(=O)c3ccc([N+](=O)[O-])cc3)cc2)cc1OC(C)=O 10.1039/C6MD00311G
132519568 156790 None 0 Human Binding pEC50 = 4.8 4.8 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 516 10 1 8 4.9 CC(=O)Oc1ccc(/C=C/C(=O)CCc2ccc(NC(=O)c3ccc([N+](=O)[O-])cc3)cc2)cc1OC(C)=O 10.1039/C6MD00311G
CHEMBL4069939 156790 None 0 Human Binding pEC50 = 4.8 4.8 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 516 10 1 8 4.9 CC(=O)Oc1ccc(/C=C/C(=O)CCc2ccc(NC(=O)c3ccc([N+](=O)[O-])cc3)cc2)cc1OC(C)=O 10.1039/C6MD00311G
129908428 159045 None 0 Human Binding pEC50 = 4.8 4.8 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 417 8 3 5 4.6 COc1ccc(C(=O)Nc2ccc(CCC(=O)/C=C/c3ccc(O)c(O)c3)cc2)cc1 10.1039/C6MD00311G
CHEMBL4095938 159045 None 0 Human Binding pEC50 = 4.8 4.8 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 417 8 3 5 4.6 COc1ccc(C(=O)Nc2ccc(CCC(=O)/C=C/c3ccc(O)c(O)c3)cc2)cc1 10.1039/C6MD00311G
129908452 156123 None 0 Human Binding pEC50 = 4.8 4.8 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 518 11 1 8 4.8 CC(=O)Oc1ccc(CCC(=O)CCc2ccc(NC(=O)c3ccc([N+](=O)[O-])cc3)cc2)cc1OC(C)=O 10.1039/C6MD00311G
CHEMBL4062349 156123 None 0 Human Binding pEC50 = 4.8 4.8 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 518 11 1 8 4.8 CC(=O)Oc1ccc(CCC(=O)CCc2ccc(NC(=O)c3ccc([N+](=O)[O-])cc3)cc2)cc1OC(C)=O 10.1039/C6MD00311G
3002977 2460 None 43 Human Binding pEC50 = 7.8 7.8 -1 2
Inhibition of CCR5-mediated HIV-1 Bal entry in human GHOST CCR5 cells assessed as decrease in viral reverse transcriptase activity by measuring [3H]thymidine triphosphate incorporation measured after 60 to 90 mins by scintillation counting analysisInhibition of CCR5-mediated HIV-1 Bal entry in human GHOST CCR5 cells assessed as decrease in viral reverse transcriptase activity by measuring [3H]thymidine triphosphate incorporation measured after 60 to 90 mins by scintillation counting analysis
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.1c00408
3002977.0 2460 None 43 Human Binding pEC50 = 7.8 7.8 -1 2
Inhibition of CCR5-mediated HIV-1 Bal entry in human GHOST CCR5 cells assessed as decrease in viral reverse transcriptase activity by measuring [3H]thymidine triphosphate incorporation measured after 60 to 90 mins by scintillation counting analysisInhibition of CCR5-mediated HIV-1 Bal entry in human GHOST CCR5 cells assessed as decrease in viral reverse transcriptase activity by measuring [3H]thymidine triphosphate incorporation measured after 60 to 90 mins by scintillation counting analysis
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.1c00408
803 2460 None 43 Human Binding pEC50 = 7.8 7.8 -1 2
Inhibition of CCR5-mediated HIV-1 Bal entry in human GHOST CCR5 cells assessed as decrease in viral reverse transcriptase activity by measuring [3H]thymidine triphosphate incorporation measured after 60 to 90 mins by scintillation counting analysisInhibition of CCR5-mediated HIV-1 Bal entry in human GHOST CCR5 cells assessed as decrease in viral reverse transcriptase activity by measuring [3H]thymidine triphosphate incorporation measured after 60 to 90 mins by scintillation counting analysis
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.1c00408
806 2460 None 43 Human Binding pEC50 = 7.8 7.8 -1 2
Inhibition of CCR5-mediated HIV-1 Bal entry in human GHOST CCR5 cells assessed as decrease in viral reverse transcriptase activity by measuring [3H]thymidine triphosphate incorporation measured after 60 to 90 mins by scintillation counting analysisInhibition of CCR5-mediated HIV-1 Bal entry in human GHOST CCR5 cells assessed as decrease in viral reverse transcriptase activity by measuring [3H]thymidine triphosphate incorporation measured after 60 to 90 mins by scintillation counting analysis
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.1c00408
CHEMBL1201187 2460 None 43 Human Binding pEC50 = 7.8 7.8 -1 2
Inhibition of CCR5-mediated HIV-1 Bal entry in human GHOST CCR5 cells assessed as decrease in viral reverse transcriptase activity by measuring [3H]thymidine triphosphate incorporation measured after 60 to 90 mins by scintillation counting analysisInhibition of CCR5-mediated HIV-1 Bal entry in human GHOST CCR5 cells assessed as decrease in viral reverse transcriptase activity by measuring [3H]thymidine triphosphate incorporation measured after 60 to 90 mins by scintillation counting analysis
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.1c00408
CHEMBL256907 2460 None 43 Human Binding pEC50 = 7.8 7.8 -1 2
Inhibition of CCR5-mediated HIV-1 Bal entry in human GHOST CCR5 cells assessed as decrease in viral reverse transcriptase activity by measuring [3H]thymidine triphosphate incorporation measured after 60 to 90 mins by scintillation counting analysisInhibition of CCR5-mediated HIV-1 Bal entry in human GHOST CCR5 cells assessed as decrease in viral reverse transcriptase activity by measuring [3H]thymidine triphosphate incorporation measured after 60 to 90 mins by scintillation counting analysis
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.1c00408
CHEMBL584744 2460 None 43 Human Binding pEC50 = 7.8 7.8 -1 2
Inhibition of CCR5-mediated HIV-1 Bal entry in human GHOST CCR5 cells assessed as decrease in viral reverse transcriptase activity by measuring [3H]thymidine triphosphate incorporation measured after 60 to 90 mins by scintillation counting analysisInhibition of CCR5-mediated HIV-1 Bal entry in human GHOST CCR5 cells assessed as decrease in viral reverse transcriptase activity by measuring [3H]thymidine triphosphate incorporation measured after 60 to 90 mins by scintillation counting analysis
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.1c00408
DB04835 2460 None 43 Human Binding pEC50 = 7.8 7.8 -1 2
Inhibition of CCR5-mediated HIV-1 Bal entry in human GHOST CCR5 cells assessed as decrease in viral reverse transcriptase activity by measuring [3H]thymidine triphosphate incorporation measured after 60 to 90 mins by scintillation counting analysisInhibition of CCR5-mediated HIV-1 Bal entry in human GHOST CCR5 cells assessed as decrease in viral reverse transcriptase activity by measuring [3H]thymidine triphosphate incorporation measured after 60 to 90 mins by scintillation counting analysis
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/acs.jmedchem.1c00408
129908456 157966 None 0 Human Binding pEC50 = 4.7 4.7 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 395 8 3 4 4.8 O=C(CCc1ccc(NC(=O)C2CCCCC2)cc1)CCc1ccc(O)c(O)c1 10.1039/C6MD00311G
CHEMBL4083941 157966 None 0 Human Binding pEC50 = 4.7 4.7 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 395 8 3 4 4.8 O=C(CCc1ccc(NC(=O)C2CCCCC2)cc1)CCc1ccc(O)c(O)c1 10.1039/C6MD00311G
129908453 157978 None 0 Human Binding pEC50 = 4.7 4.7 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 479 10 1 6 5.2 CC(=O)Oc1ccc(CCC(=O)CCc2ccc(NC(=O)C3CCCCC3)cc2)cc1OC(C)=O 10.1039/C6MD00311G
CHEMBL4084066 157978 None 0 Human Binding pEC50 = 4.7 4.7 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 479 10 1 6 5.2 CC(=O)Oc1ccc(CCC(=O)CCc2ccc(NC(=O)C3CCCCC3)cc2)cc1OC(C)=O 10.1039/C6MD00311G
129908111 157762 None 0 Human Binding pEC50 = 4.7 4.7 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 501 10 1 7 5.0 COc1ccc(C(=O)Nc2ccc(CCC(=O)/C=C/c3ccc(OC(C)=O)c(OC(C)=O)c3)cc2)cc1 10.1039/C6MD00311G
CHEMBL4081563 157762 None 0 Human Binding pEC50 = 4.7 4.7 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 501 10 1 7 5.0 COc1ccc(C(=O)Nc2ccc(CCC(=O)/C=C/c3ccc(OC(C)=O)c(OC(C)=O)c3)cc2)cc1 10.1039/C6MD00311G
129908196 157122 None 0 Human Binding pEC50 = 4.6 4.6 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 389 8 3 4 4.5 O=C(CCc1ccc(NC(=O)c2ccccc2)cc1)CCc1ccc(O)c(O)c1 10.1039/C6MD00311G
CHEMBL4073567 157122 None 0 Human Binding pEC50 = 4.6 4.6 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 389 8 3 4 4.5 O=C(CCc1ccc(NC(=O)c2ccccc2)cc1)CCc1ccc(O)c(O)c1 10.1039/C6MD00311G
129908454 158178 None 0 Human Binding pEC50 = 4.6 4.6 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 487 10 1 6 5.2 CC(=O)Oc1ccc(CCC(=O)CCc2ccc(NC(=O)c3ccc(C)cc3)cc2)cc1OC(C)=O 10.1039/C6MD00311G
CHEMBL4086440 158178 None 0 Human Binding pEC50 = 4.6 4.6 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 487 10 1 6 5.2 CC(=O)Oc1ccc(CCC(=O)CCc2ccc(NC(=O)c3ccc(C)cc3)cc2)cc1OC(C)=O 10.1039/C6MD00311G
129908109 158434 None 0 Human Binding pEC50 = 4.5 4.5 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 477 9 1 6 5.3 CC(=O)Oc1ccc(/C=C/C(=O)CCc2ccc(NC(=O)C3CCCCC3)cc2)cc1OC(C)=O 10.1039/C6MD00311G
CHEMBL4089429 158434 None 0 Human Binding pEC50 = 4.5 4.5 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 477 9 1 6 5.3 CC(=O)Oc1ccc(/C=C/C(=O)CCc2ccc(NC(=O)C3CCCCC3)cc2)cc1OC(C)=O 10.1039/C6MD00311G
129908455 156352 None 0 Human Binding pEC50 = 4.5 4.5 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 503 11 1 7 4.9 COc1ccc(C(=O)Nc2ccc(CCC(=O)CCc3ccc(OC(C)=O)c(OC(C)=O)c3)cc2)cc1 10.1039/C6MD00311G
CHEMBL4064975 156352 None 0 Human Binding pEC50 = 4.5 4.5 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 503 11 1 7 4.9 COc1ccc(C(=O)Nc2ccc(CCC(=O)CCc3ccc(OC(C)=O)c(OC(C)=O)c3)cc2)cc1 10.1039/C6MD00311G
129908558 156264 None 0 Human Binding pEC50 = 4.4 4.4 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 403 8 3 4 4.8 Cc1ccc(C(=O)Nc2ccc(CCC(=O)CCc3ccc(O)c(O)c3)cc2)cc1 10.1039/C6MD00311G
CHEMBL4063935 156264 None 0 Human Binding pEC50 = 4.4 4.4 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 403 8 3 4 4.8 Cc1ccc(C(=O)Nc2ccc(CCC(=O)CCc3ccc(O)c(O)c3)cc2)cc1 10.1039/C6MD00311G
129907953 159597 None 0 Human Binding pEC50 = 4.4 4.4 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 434 9 3 6 4.4 O=C(CCc1ccc(NC(=O)c2ccc([N+](=O)[O-])cc2)cc1)CCc1ccc(O)c(O)c1 10.1039/C6MD00311G
132519569 159597 None 0 Human Binding pEC50 = 4.4 4.4 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 434 9 3 6 4.4 O=C(CCc1ccc(NC(=O)c2ccc([N+](=O)[O-])cc2)cc1)CCc1ccc(O)c(O)c1 10.1039/C6MD00311G
CHEMBL4101931 159597 None 0 Human Binding pEC50 = 4.4 4.4 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 434 9 3 6 4.4 O=C(CCc1ccc(NC(=O)c2ccc([N+](=O)[O-])cc2)cc1)CCc1ccc(O)c(O)c1 10.1039/C6MD00311G
129908281 158666 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 473 10 1 6 4.9 CC(=O)Oc1ccc(CCC(=O)CCc2ccc(NC(=O)c3ccccc3)cc2)cc1OC(C)=O 10.1039/C6MD00311G
CHEMBL4091826 158666 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 473 10 1 6 4.9 CC(=O)Oc1ccc(CCC(=O)CCc2ccc(NC(=O)c3ccccc3)cc2)cc1OC(C)=O 10.1039/C6MD00311G
129908560 157023 None 0 Human Binding pEC50 = 4.3 4.3 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 409 9 3 5 4.5 O=C(CCc1ccc(NC(=O)Cc2cccs2)cc1)CCc1ccc(O)c(O)c1 10.1039/C6MD00311G
CHEMBL4072528 157023 None 0 Human Binding pEC50 = 4.3 4.3 - 0
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
ChEMBL 409 9 3 5 4.5 O=C(CCc1ccc(NC(=O)Cc2cccs2)cc1)CCc1ccc(O)c(O)c1 10.1039/C6MD00311G
CHEMBL5074744 216817 None 0 Human Binding pEC50 = 7.0 7.0 - 2
Inhibition of CCR5-mediated HIV-1 Bal entry in human GHOST CCR5 cells assessed as decrease in viral reverse transcriptase activity by measuring [3H]thymidine triphosphate incorporation measured after 60 to 90 mins by scintillation counting analysisInhibition of CCR5-mediated HIV-1 Bal entry in human GHOST CCR5 cells assessed as decrease in viral reverse transcriptase activity by measuring [3H]thymidine triphosphate incorporation measured after 60 to 90 mins by scintillation counting analysis
ChEMBL None None None CC(C)c1nnc(CCNC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)N[C@@H]2CC[C@@]3(O)[C@H]4Cc5ccc(O)c6c5[C@@]3(CCN4CC3CC3)[C@H]2O6)n1C1C[C@H]2CC[C@@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1 10.1021/acs.jmedchem.1c00408
483747 105465 None 1 Human Binding pIC50 = 11 11.0 177 4
Inhibition of 0.1 nM of MIP-1beta induced migration of recombinant mouse pro-B cell line BA/F3 expressing human CCR5Inhibition of 0.1 nM of MIP-1beta induced migration of recombinant mouse pro-B cell line BA/F3 expressing human CCR5
ChEMBL 503 4 0 5 4.9 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1 10.1016/s0960-894x(02)00918-6
CHEMBL311795 105465 None 1 Human Binding pIC50 = 11 11.0 177 4
Inhibition of 0.1 nM of MIP-1beta induced migration of recombinant mouse pro-B cell line BA/F3 expressing human CCR5Inhibition of 0.1 nM of MIP-1beta induced migration of recombinant mouse pro-B cell line BA/F3 expressing human CCR5
ChEMBL 503 4 0 5 4.9 Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1 10.1016/s0960-894x(02)00918-6
44590586 176915 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 543 10 1 3 6.3 CCN(C(=O)Cc1ccc(Cl)c(Cl)c1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 10.1016/j.bmcl.2009.01.009
CHEMBL460845 176915 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 543 10 1 3 6.3 CCN(C(=O)Cc1ccc(Cl)c(Cl)c1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 10.1016/j.bmcl.2009.01.009
10076141 78420 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 546 11 1 3 6.5 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL21106 78420 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 546 11 1 3 6.5 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
10076141 78420 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 546 11 1 3 6.5 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00829-6
CHEMBL21106 78420 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 546 11 1 3 6.5 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00829-6
CHEMBL181276 211440 None 44 Human Binding pIC50 = 10.2 10.2 - 0
Antagonist activity at CCR5 (unknown origin) expressed in human HOS cells co-expressing HIV-1 FITC-gp120 Bal assessed inhibition of CD4 dependent gp120 Bal binding to CCR5 by western blot analysisAntagonist activity at CCR5 (unknown origin) expressed in human HOS cells co-expressing HIV-1 FITC-gp120 Bal assessed inhibition of CD4 dependent gp120 Bal binding to CCR5 by western blot analysis
ChEMBL None None None C[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(N)=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O 10.1016/j.ejmech.2020.112819
10076141 78420 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 546 11 1 3 6.5 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL21106 78420 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 546 11 1 3 6.5 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
44590681 175277 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 553 11 1 5 4.4 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 10.1016/j.bmcl.2009.01.009
CHEMBL457043 175277 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 553 11 1 5 4.4 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 10.1016/j.bmcl.2009.01.009
44273531 75058 None 0 Human Binding pIC50 = 10 10.0 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 542 11 1 4 6.5 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCSc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00829-6
CHEMBL20345 75058 None 0 Human Binding pIC50 = 10 10.0 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 542 11 1 4 6.5 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCSc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00829-6
501062 77763 None 0 Human Binding pIC50 = 10 10.0 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 488 11 1 3 6.1 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/s0960-894x(02)00829-6
CHEMBL20896 77763 None 0 Human Binding pIC50 = 10 10.0 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 488 11 1 3 6.1 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/s0960-894x(02)00829-6
501062 77763 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 488 11 1 3 6.1 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2005.02.030
CHEMBL20896 77763 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 488 11 1 3 6.1 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2005.02.030
44273531 75058 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 542 11 1 4 6.5 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCSc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL20345 75058 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 542 11 1 4 6.5 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCSc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
44332684 107236 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 474 11 1 3 5.7 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL316475 107236 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 474 11 1 3 5.7 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
501060 108642 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 474 10 1 3 5.7 O=C(O)[C@@H](C1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL320386 108642 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 474 10 1 3 5.7 O=C(O)[C@@H](C1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
501055 4615 None 0 Human Binding pIC50 = 10 10.0 - 0
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
ChEMBL 502 10 1 3 6.5 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/s0960-894x(02)00606-6
CHEMBL102826 4615 None 0 Human Binding pIC50 = 10 10.0 - 0
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
ChEMBL 502 10 1 3 6.5 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/s0960-894x(02)00606-6
501062 77763 None 0 Human Binding pIC50 = 10 10.0 - 0
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
ChEMBL 488 11 1 3 6.1 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/s0960-894x(02)00606-6
CHEMBL20896 77763 None 0 Human Binding pIC50 = 10 10.0 - 0
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
ChEMBL 488 11 1 3 6.1 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/s0960-894x(02)00606-6
44332684 107236 None 0 Human Binding pIC50 = 10 10.0 - 0
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
ChEMBL 474 11 1 3 5.7 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/s0960-894x(02)00606-6
CHEMBL316475 107236 None 0 Human Binding pIC50 = 10 10.0 - 0
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
ChEMBL 474 11 1 3 5.7 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/s0960-894x(02)00606-6
501060 108642 None 0 Human Binding pIC50 = 10 10.0 - 0
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
ChEMBL 474 10 1 3 5.7 O=C(O)[C@@H](C1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/s0960-894x(02)00606-6
CHEMBL320386 108642 None 0 Human Binding pIC50 = 10 10.0 - 0
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
ChEMBL 474 10 1 3 5.7 O=C(O)[C@@H](C1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/s0960-894x(02)00606-6
490018 111686 None 0 Human Binding pIC50 = 10 10.0 - 0
Inhibition of human CCR5Inhibition of human CCR5
ChEMBL 568 11 0 6 6.1 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(Cc3ccccc3)C[C@@H]2c2ccccc2)CC1 10.1021/acs.jmedchem.6b01309
CHEMBL328445 111686 None 0 Human Binding pIC50 = 10 10.0 - 0
Inhibition of human CCR5Inhibition of human CCR5
ChEMBL 568 11 0 6 6.1 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(Cc3ccccc3)C[C@@H]2c2ccccc2)CC1 10.1021/acs.jmedchem.6b01309
490018 111686 None 0 Human Binding pIC50 = 10 10.0 - 0
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
ChEMBL 568 11 0 6 6.1 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(Cc3ccccc3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(01)00545-5
CHEMBL328445 111686 None 0 Human Binding pIC50 = 10 10.0 - 0
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
ChEMBL 568 11 0 6 6.1 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(Cc3ccccc3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(01)00545-5
3002976 209735 None 0 Human Binding pIC50 = 10 10.0 - 0
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
ChEMBL 634 14 0 7 5.9 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(CC[C@](C)(CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1 10.1016/s0960-894x(01)00545-5
CHEMBL93139 209735 None 0 Human Binding pIC50 = 10 10.0 - 0
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
ChEMBL 634 14 0 7 5.9 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(CC[C@](C)(CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1 10.1016/s0960-894x(01)00545-5
44373756 50634 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Ability to displace [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesAbility to displace [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 588 9 0 7 6.3 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN3OC4(CCCCC4)C[C@H]3[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(01)00835-6
CHEMBL157491 50634 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Ability to displace [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesAbility to displace [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 588 9 0 7 6.3 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN3OC4(CCCCC4)C[C@H]3[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(01)00835-6
11988311 179444 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 451 8 1 5 5.2 Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CCCC2)c2ccccc2)CC1 10.1016/j.bmcl.2009.01.008
CHEMBL473558 179444 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 451 8 1 5 5.2 Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CCCC2)c2ccccc2)CC1 10.1016/j.bmcl.2009.01.008
44590750 177001 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 490 10 2 3 5.1 CCN(C(=O)NCc1ccccc1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 10.1016/j.bmcl.2009.01.009
CHEMBL461687 177001 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 490 10 2 3 5.1 CCN(C(=O)NCc1ccccc1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 10.1016/j.bmcl.2009.01.009
71451877 82603 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Binding affinity to CCR5Binding affinity to CCR5
ChEMBL 638 11 0 6 5.0 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cc(F)cc(F)c2)C2CCC(S(C)(=O)=O)CC2)CC1 10.1021/jm300682j
CHEMBL2178577 82603 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Binding affinity to CCR5Binding affinity to CCR5
ChEMBL 638 11 0 6 5.0 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cc(F)cc(F)c2)C2CCC(S(C)(=O)=O)CC2)CC1 10.1021/jm300682j
44274043 76582 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 542 11 1 3 6.8 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2ccccc2)C1 10.1016/s0960-894x(02)00829-6
CHEMBL20622 76582 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 542 11 1 3 6.8 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2ccccc2)C1 10.1016/s0960-894x(02)00829-6
44273830 79641 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 574 11 1 3 7.2 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccc(C(F)(F)F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00829-6
CHEMBL21147 79641 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 574 11 1 3 7.2 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccc(C(F)(F)F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00829-6
3002977 2460 None 43 Human Binding pIC50 = 9.7 9.7 -1 2
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmcl.2009.01.008
3002977 2460 None 43 Human Binding pIC50 = 9.7 9.7 -1 2
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmcl.2009.01.009
3002977.0 2460 None 43 Human Binding pIC50 = 9.7 9.7 -1 2
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmcl.2009.01.008
3002977.0 2460 None 43 Human Binding pIC50 = 9.7 9.7 -1 2
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmcl.2009.01.009
803 2460 None 43 Human Binding pIC50 = 9.7 9.7 -1 2
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmcl.2009.01.008
803 2460 None 43 Human Binding pIC50 = 9.7 9.7 -1 2
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmcl.2009.01.009
806 2460 None 43 Human Binding pIC50 = 9.7 9.7 -1 2
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmcl.2009.01.008
806 2460 None 43 Human Binding pIC50 = 9.7 9.7 -1 2
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmcl.2009.01.009
CHEMBL1201187 2460 None 43 Human Binding pIC50 = 9.7 9.7 -1 2
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmcl.2009.01.008
CHEMBL1201187 2460 None 43 Human Binding pIC50 = 9.7 9.7 -1 2
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmcl.2009.01.009
CHEMBL256907 2460 None 43 Human Binding pIC50 = 9.7 9.7 -1 2
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmcl.2009.01.008
CHEMBL256907 2460 None 43 Human Binding pIC50 = 9.7 9.7 -1 2
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmcl.2009.01.009
CHEMBL584744 2460 None 43 Human Binding pIC50 = 9.7 9.7 -1 2
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmcl.2009.01.008
CHEMBL584744 2460 None 43 Human Binding pIC50 = 9.7 9.7 -1 2
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmcl.2009.01.009
DB04835 2460 None 43 Human Binding pIC50 = 9.7 9.7 -1 2
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmcl.2009.01.008
DB04835 2460 None 43 Human Binding pIC50 = 9.7 9.7 -1 2
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1016/j.bmcl.2009.01.009
10414981 108197 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 542 10 2 6 5.3 OC1(CCCc2ccc(-c3nnn[nH]3)cc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00605-4
CHEMBL319593 108197 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 542 10 2 6 5.3 OC1(CCCc2ccc(-c3nnn[nH]3)cc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00605-4
44332341 109708 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 556 10 1 7 5.3 Cn1nnnc1-c1ccc(CCCC2(O)CCN(C[C@H]3CN(CC4CCCCC4)C[C@@H]3c3ccccc3)CC2)cc1 10.1016/s0960-894x(02)00605-4
CHEMBL322422 109708 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 556 10 1 7 5.3 Cn1nnnc1-c1ccc(CCCC2(O)CCN(C[C@H]3CN(CC4CCCCC4)C[C@@H]3c3ccccc3)CC2)cc1 10.1016/s0960-894x(02)00605-4
44274043 76582 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 542 11 1 3 6.8 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL20622 76582 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 542 11 1 3 6.8 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
44273830 79641 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 574 11 1 3 7.2 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccc(C(F)(F)F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL21147 79641 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 574 11 1 3 7.2 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccc(C(F)(F)F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
10414981 108197 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 542 10 2 6 5.3 OC1(CCCc2ccc(-c3nnn[nH]3)cc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/j.ejmech.2008.01.040
CHEMBL319593 108197 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 542 10 2 6 5.3 OC1(CCCc2ccc(-c3nnn[nH]3)cc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/j.ejmech.2008.01.040
501063 210891 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 488 10 1 3 6.1 O=C(O)[C@@H](C1CCCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL99909 210891 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 488 10 1 3 6.1 O=C(O)[C@@H](C1CCCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
10414981 108197 None 0 Human Binding pIC50 = 9.7 9.7 - 0
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
ChEMBL 542 10 2 6 5.3 OC1(CCCc2ccc(-c3nnn[nH]3)cc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00606-6
CHEMBL319593 108197 None 0 Human Binding pIC50 = 9.7 9.7 - 0
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
ChEMBL 542 10 2 6 5.3 OC1(CCCc2ccc(-c3nnn[nH]3)cc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00606-6
501063 210891 None 0 Human Binding pIC50 = 9.7 9.7 - 0
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
ChEMBL 488 10 1 3 6.1 O=C(O)[C@@H](C1CCCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/s0960-894x(02)00606-6
CHEMBL99909 210891 None 0 Human Binding pIC50 = 9.7 9.7 - 0
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
ChEMBL 488 10 1 3 6.1 O=C(O)[C@@H](C1CCCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/s0960-894x(02)00606-6
501055 4615 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibition of human CX3C chemokine receptor 5 from GP120-membrane-based assayInhibition of human CX3C chemokine receptor 5 from GP120-membrane-based assay
ChEMBL 502 10 1 3 6.5 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2003.12.004
CHEMBL102826 4615 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibition of human CX3C chemokine receptor 5 from GP120-membrane-based assayInhibition of human CX3C chemokine receptor 5 from GP120-membrane-based assay
ChEMBL 502 10 1 3 6.5 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2003.12.004
516310 59629 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 642 12 1 6 7.1 CCn1nc(Cc2ccc(OC3CC3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL171958 59629 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 642 12 1 6 7.1 CCn1nc(Cc2ccc(OC3CC3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516257 60003 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 610 11 1 5 7.2 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc5ccccc5c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL173400 60003 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 610 11 1 5 7.2 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc5ccccc5c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516288 60418 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 610 9 1 5 7.2 CCn1nc(Cc2cccc3ccccc23)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL174927 60418 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 610 9 1 5 7.2 CCn1nc(Cc2cccc3ccccc23)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516256 128714 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 610 11 1 5 7.2 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4cccc5ccccc45)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL366770 128714 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 610 11 1 5 7.2 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4cccc5ccccc45)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516289 131614 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 610 9 1 5 7.2 CCn1nc(Cc2ccc3ccccc3c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL369235 131614 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 610 9 1 5 7.2 CCn1nc(Cc2ccc3ccccc3c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
490023 112574 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
ChEMBL 574 10 0 6 5.6 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(01)00545-5
CHEMBL329893 112574 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
ChEMBL 574 10 0 6 5.6 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(01)00545-5
490019 168081 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
ChEMBL 582 10 0 6 5.7 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)c3ccccc3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(01)00545-5
CHEMBL431852 168081 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
ChEMBL 582 10 0 6 5.7 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)c3ccccc3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(01)00545-5
9916998 80017 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
ChEMBL 614 11 0 6 4.7 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cccc(F)c2)CC1 10.1016/j.bmcl.2006.03.089
CHEMBL212731 80017 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
ChEMBL 614 11 0 6 4.7 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cccc(F)c2)CC1 10.1016/j.bmcl.2006.03.089
3010274 189332 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 543 10 1 5 6.3 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL511493 189332 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 543 10 1 5 6.3 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
3010273 192065 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 529 10 1 5 5.9 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL520091 192065 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 529 10 1 5 5.9 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
44342962 111280 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 529 10 1 5 5.9 O=C(O)C(CC1CC1)N1CC(c2ccccc2)[C@@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)C1 10.1016/j.bmcl.2004.04.078
CHEMBL326487 111280 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 529 10 1 5 5.9 O=C(O)C(CC1CC1)N1CC(c2ccccc2)[C@@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)C1 10.1016/j.bmcl.2004.04.078
44342961 114599 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 543 10 1 5 6.3 O=C(O)C(CC1CCC1)N1CC(c2ccccc2)[C@@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)C1 10.1016/j.bmcl.2004.04.078
CHEMBL333619 114599 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 543 10 1 5 6.3 O=C(O)C(CC1CCC1)N1CC(c2ccccc2)[C@@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)C1 10.1016/j.bmcl.2004.04.078
3010274 189332 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 543 10 1 5 6.3 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL511493 189332 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 543 10 1 5 6.3 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
3010273 192065 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 529 10 1 5 5.9 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL520091 192065 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 529 10 1 5 5.9 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
11285792 879 None 32 Mouse Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hrDisplacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hr
ChEMBL 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 10.1016/j.ejmech.2018.01.085
801 879 None 32 Mouse Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hrDisplacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hr
ChEMBL 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 10.1016/j.ejmech.2018.01.085
CHEMBL2110727 879 None 32 Mouse Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hrDisplacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hr
ChEMBL 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 10.1016/j.ejmech.2018.01.085
DB11758 879 None 32 Mouse Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hrDisplacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hr
ChEMBL 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 10.1016/j.ejmech.2018.01.085
11614352 550 None 1 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
ChEMBL 639 11 0 6 4.1 CCN(C(=O)Cc1ccc(cc1)S(=O)(=O)C)C1CCN(CC1)CC[C@@H](c1cc(F)cc(c1)F)C1CCN(CC1)S(=O)(=O)C 10.1016/j.bmcl.2011.12.117
7686 550 None 1 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
ChEMBL 639 11 0 6 4.1 CCN(C(=O)Cc1ccc(cc1)S(=O)(=O)C)C1CCN(CC1)CC[C@@H](c1cc(F)cc(c1)F)C1CCN(CC1)S(=O)(=O)C 10.1016/j.bmcl.2011.12.117
CHEMBL1951914 550 None 1 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
ChEMBL 639 11 0 6 4.1 CCN(C(=O)Cc1ccc(cc1)S(=O)(=O)C)C1CCN(CC1)CC[C@@H](c1cc(F)cc(c1)F)C1CCN(CC1)S(=O)(=O)C 10.1016/j.bmcl.2011.12.117
3010264 183909 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 557 9 1 5 6.7 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL480503 183909 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 557 9 1 5 6.7 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
3010264 183909 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 557 9 1 5 6.7 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL480503 183909 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 557 9 1 5 6.7 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
3010264 183909 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 557 9 1 5 6.7 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2004.04.078
CHEMBL480503 183909 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 557 9 1 5 6.7 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2004.04.078
10347790 78490 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 560 11 1 3 6.9 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL21117 78490 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 560 11 1 3 6.9 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
44565720 174433 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 570 11 1 3 7.5 O=C(O)[C@@H](CC1CCCCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL455073 174433 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 570 11 1 3 7.5 O=C(O)[C@@H](CC1CCCCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
20672370 78062 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 531 11 1 4 6.1 N#Cc1ccc(CCCC2CCN(C[C@H]3CN([C@H](CC4CCC4)C(=O)O)C[C@@H]3c3cccc(F)c3)CC2)cc1 10.1016/s0960-894x(02)00829-6
CHEMBL20988 78062 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 531 11 1 4 6.1 N#Cc1ccc(CCCC2CCN(C[C@H]3CN([C@H](CC4CCC4)C(=O)O)C[C@@H]3c3cccc(F)c3)CC2)cc1 10.1016/s0960-894x(02)00829-6
10347790 78490 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 560 11 1 3 6.9 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00829-6
CHEMBL21117 78490 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 560 11 1 3 6.9 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00829-6
20672362 99490 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 556 10 1 3 7.2 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2ccccc2)C1 10.1016/s0960-894x(02)00829-6
CHEMBL282921 99490 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 556 10 1 3 7.2 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2ccccc2)C1 10.1016/s0960-894x(02)00829-6
10369469 70373 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 522 8 1 5 5.2 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccc(F)cn34)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2005.02.030
CHEMBL194497 70373 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 522 8 1 5 5.2 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccc(F)cn34)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2005.02.030
489315 107416 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes.Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes.
ChEMBL 474 9 1 3 6.1 OC1(CCCc2ccccc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00605-4
CHEMBL317710 107416 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes.Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes.
ChEMBL 474 9 1 3 6.1 OC1(CCCc2ccccc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00605-4
10347790 78490 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 560 11 1 3 6.9 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL21117 78490 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 560 11 1 3 6.9 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
44565720 174433 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 570 11 1 3 7.5 O=C(O)[C@@H](CC1CCCCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL455073 174433 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 570 11 1 3 7.5 O=C(O)[C@@H](CC1CCCCC1)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
72712598 92692 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 591 5 0 4 6.6 Cc1cc(Cl)nc(C)c1C(=O)N1CCC(C)(N2CCC(N3C(=O)N(C4CCCCC4)C[C@H]3c3ccccc3)CC2)CC1 10.1021/jm401101p
CHEMBL2435848 92692 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 591 5 0 4 6.6 Cc1cc(Cl)nc(C)c1C(=O)N1CCC(C)(N2CCC(N3C(=O)N(C4CCCCC4)C[C@H]3c3ccccc3)CC2)CC1 10.1021/jm401101p
516231 59873 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 610 11 1 5 7.2 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc5ccccc5c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL172894 59873 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 610 11 1 5 7.2 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc5ccccc5c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516245 59880 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 616 13 1 6 6.6 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC5CC5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL172916 59880 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 616 13 1 6 6.6 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC5CC5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516235 60237 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 636 12 1 5 7.7 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(-c5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL174004 60237 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 636 12 1 5 7.7 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(-c5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516224 61675 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 626 13 1 6 6.6 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL177127 61675 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 626 13 1 6 6.6 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516234 99054 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 616 11 1 5 7.3 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C(C)(C)C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL279992 99054 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 616 11 1 5 7.3 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C(C)(C)C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516233 128747 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 602 12 1 5 7.2 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C(C)C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL366868 128747 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 602 12 1 5 7.2 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C(C)C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516202 130349 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 622 11 1 5 7.3 CCn1nc(Cc2ccc(-c3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL367987 130349 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 622 11 1 5 7.3 CCn1nc(Cc2ccc(-c3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516314 130751 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 662 11 1 5 8.2 CCn1nc(Cc2ccc(-c3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL368329 130751 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 662 11 1 5 8.2 CCn1nc(Cc2ccc(-c3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516216 131505 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 616 13 1 6 6.6 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC5CC5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL369059 131505 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 616 13 1 6 6.6 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC5CC5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516262 166459 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 628 9 1 5 7.0 CCn1nc(Cc2ccc(C(F)(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL427493 166459 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 628 9 1 5 7.0 CCn1nc(Cc2ccc(C(F)(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516232 168634 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 574 11 1 5 6.3 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL435472 168634 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 574 11 1 5 6.3 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL181276 211440 None 44 Human Binding pIC50 = 9.5 9.5 - 0
Antagonist activity at CCR5 (unknown origin) expressed in human HOS cells co-expressing HIV-1 FITC-gp120 CM235 assessed inhibition of CD4 dependent gp120 CM235 binding to CCR5 by western blot analysisAntagonist activity at CCR5 (unknown origin) expressed in human HOS cells co-expressing HIV-1 FITC-gp120 CM235 assessed inhibition of CD4 dependent gp120 CM235 binding to CCR5 by western blot analysis
ChEMBL None None None C[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(N)=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O 10.1016/j.ejmech.2020.112819
16007088 80007 None 24 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity to CCR5Binding affinity to CCR5
ChEMBL 632 11 0 6 4.8 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cc(F)cc(F)c2)CC1 10.1021/jm300682j
CHEMBL212689 80007 None 24 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity to CCR5Binding affinity to CCR5
ChEMBL 632 11 0 6 4.8 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cc(F)cc(F)c2)CC1 10.1021/jm300682j
16007088 80007 None 24 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
ChEMBL 632 11 0 6 4.8 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cc(F)cc(F)c2)CC1 10.1016/j.bmcl.2006.03.089
CHEMBL212689 80007 None 24 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
ChEMBL 632 11 0 6 4.8 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cc(F)cc(F)c2)CC1 10.1016/j.bmcl.2006.03.089
16007088 80007 None 24 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
ChEMBL 632 11 0 6 4.8 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cc(F)cc(F)c2)CC1 10.1016/j.bmcl.2011.12.117
CHEMBL212689 80007 None 24 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
ChEMBL 632 11 0 6 4.8 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cc(F)cc(F)c2)CC1 10.1016/j.bmcl.2011.12.117
3010271 183948 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 527 10 1 5 5.8 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)o3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL480693 183948 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 527 10 1 5 5.8 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)o3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
44590633 176308 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 509 10 1 3 5.6 CCN(C(=O)Cc1ccc(Cl)cc1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 10.1016/j.bmcl.2009.01.009
CHEMBL459384 176308 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 509 10 1 3 5.6 CCN(C(=O)Cc1ccc(Cl)cc1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 10.1016/j.bmcl.2009.01.009
3010271 183948 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 527 10 1 5 5.8 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)o3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL480693 183948 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 527 10 1 5 5.8 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)o3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
3010271 183948 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 527 10 1 5 5.8 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)o3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2004.04.078
CHEMBL480693 183948 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 527 10 1 5 5.8 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)o3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2004.04.078
44401488 70099 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 532 9 1 5 5.6 CCc1ccn2c(C3CCN(C[C@H]4CN([C@H](CC5CCC5)C(=O)O)C[C@@H]4c4cccc(F)c4)CC3)cnc2c1 10.1016/j.bmcl.2005.02.030
CHEMBL193984 70099 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 532 9 1 5 5.6 CCc1ccn2c(C3CCN(C[C@H]4CN([C@H](CC5CCC5)C(=O)O)C[C@@H]4c4cccc(F)c4)CC3)cnc2c1 10.1016/j.bmcl.2005.02.030
53260398 62883 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of 125I-MIP-1beta from human CCR5 receptor after 4 hrs by scintillation countingDisplacement of 125I-MIP-1beta from human CCR5 receptor after 4 hrs by scintillation counting
ChEMBL 512 5 0 4 6.5 Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CCC1(c2ccccc2)CCN(C(=O)C(C)(C)C)CC1 10.1021/jm200279v
CHEMBL1784385 62883 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of 125I-MIP-1beta from human CCR5 receptor after 4 hrs by scintillation countingDisplacement of 125I-MIP-1beta from human CCR5 receptor after 4 hrs by scintillation counting
ChEMBL 512 5 0 4 6.5 Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CCC1(c2ccccc2)CCN(C(=O)C(C)(C)C)CC1 10.1021/jm200279v
3002977 2460 None 43 Human Binding pIC50 = 9.4 9.4 -1 2
Antagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 MGC26-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assayAntagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 MGC26-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/ml400370w
3002977.0 2460 None 43 Human Binding pIC50 = 9.4 9.4 -1 2
Antagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 MGC26-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assayAntagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 MGC26-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/ml400370w
803 2460 None 43 Human Binding pIC50 = 9.4 9.4 -1 2
Antagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 MGC26-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assayAntagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 MGC26-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/ml400370w
806 2460 None 43 Human Binding pIC50 = 9.4 9.4 -1 2
Antagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 MGC26-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assayAntagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 MGC26-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/ml400370w
CHEMBL1201187 2460 None 43 Human Binding pIC50 = 9.4 9.4 -1 2
Antagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 MGC26-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assayAntagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 MGC26-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/ml400370w
CHEMBL256907 2460 None 43 Human Binding pIC50 = 9.4 9.4 -1 2
Antagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 MGC26-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assayAntagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 MGC26-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/ml400370w
CHEMBL584744 2460 None 43 Human Binding pIC50 = 9.4 9.4 -1 2
Antagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 MGC26-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assayAntagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 MGC26-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/ml400370w
DB04835 2460 None 43 Human Binding pIC50 = 9.4 9.4 -1 2
Antagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 MGC26-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assayAntagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 MGC26-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/ml400370w
44565038 186964 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 473 8 1 5 5.0 Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CC(F)(F)C2)c2ccccc2)CC1 10.1016/j.bmcl.2009.01.008
CHEMBL489513 186964 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 473 8 1 5 5.0 Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CC(F)(F)C2)c2ccccc2)CC1 10.1016/j.bmcl.2009.01.008
CHEMBL491679 186964 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 473 8 1 5 5.0 Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CC(F)(F)C2)c2ccccc2)CC1 10.1016/j.bmcl.2009.01.008
3010268 78751 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 526 10 2 4 5.5 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3c[nH]c(Cc4ccccc4)n3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2004.04.078
CHEMBL2112559 78751 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 526 10 2 4 5.5 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3c[nH]c(Cc4ccccc4)n3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2004.04.078
44273996 75588 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 526 11 2 4 5.5 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL20453 75588 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 526 11 2 4 5.5 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
44565673 177746 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 556 10 1 7 5.3 Cn1nnc(-c2ccc(CCCC3(O)CCN(C[C@H]4CN(CC5CCCCC5)C[C@@H]4c4ccccc4)CC3)cc2)n1 10.1016/j.ejmech.2008.01.040
CHEMBL464132 177746 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 556 10 1 7 5.3 Cn1nnc(-c2ccc(CCCC3(O)CCN(C[C@H]4CN(CC5CCCCC5)C[C@@H]4c4ccccc4)CC3)cc2)n1 10.1016/j.ejmech.2008.01.040
44273996 75588 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 526 11 2 4 5.5 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00829-6
CHEMBL20453 75588 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 526 11 2 4 5.5 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00829-6
44273888 98822 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 558 11 1 4 5.5 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CC[S+]([O-])c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00829-6
CHEMBL278117 98822 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 558 11 1 4 5.5 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CC[S+]([O-])c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00829-6
44357079 119405 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
ChEMBL 541 11 1 6 4.8 CCCN(c1ncc(F)cn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/s0960-894x(02)00988-5
CHEMBL344261 119405 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
ChEMBL 541 11 1 6 4.8 CCCN(c1ncc(F)cn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/s0960-894x(02)00988-5
3001322 443 None 22 Mouse Binding pIC50 = 9.4 9.4 - 1
Displacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hrDisplacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hr
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.ejmech.2018.01.085
805 443 None 22 Mouse Binding pIC50 = 9.4 9.4 - 1
Displacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hrDisplacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hr
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.ejmech.2018.01.085
CHEMBL1255794 443 None 22 Mouse Binding pIC50 = 9.4 9.4 - 1
Displacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hrDisplacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hr
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.ejmech.2018.01.085
DB06497 443 None 22 Mouse Binding pIC50 = 9.4 9.4 - 1
Displacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hrDisplacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hr
ChEMBL 577 10 3 6 4.6 CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O 10.1016/j.ejmech.2018.01.085
44332489 4756 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 557 10 2 5 4.7 C[n+]1n[nH]c(-c2ccc(CCCC3(O)CCN(C[C@H]4CN(CC5CCCCC5)C[C@@H]4c4ccccc4)CC3)cc2)n1 10.1016/s0960-894x(02)00605-4
CHEMBL103790 4756 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 557 10 2 5 4.7 C[n+]1n[nH]c(-c2ccc(CCCC3(O)CCN(C[C@H]4CN(CC5CCCCC5)C[C@@H]4c4ccccc4)CC3)cc2)n1 10.1016/s0960-894x(02)00605-4
44273996 75588 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 526 11 2 4 5.5 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL20453 75588 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 526 11 2 4 5.5 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(CCC(O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
44565673 177746 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 556 10 1 7 5.3 Cn1nnc(-c2ccc(CCCC3(O)CCN(C[C@H]4CN(CC5CCCCC5)C[C@@H]4c4ccccc4)CC3)cc2)n1 10.1016/j.ejmech.2008.01.040
CHEMBL464132 177746 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 556 10 1 7 5.3 Cn1nnc(-c2ccc(CCCC3(O)CCN(C[C@H]4CN(CC5CCCCC5)C[C@@H]4c4ccccc4)CC3)cc2)n1 10.1016/j.ejmech.2008.01.040
58834969 92701 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 586 8 1 6 5.9 Cc1nc(Sc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
CHEMBL2435857 92701 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 586 8 1 6 5.9 Cc1nc(Sc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
516292 60298 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 616 9 1 5 7.3 CCn1nc(Cc2ccc(C(C)(C)C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL174214 60298 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 616 9 1 5 7.3 CCn1nc(Cc2ccc(C(C)(C)C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516201 60483 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 608 12 1 6 6.2 CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1F 10.1016/j.bmcl.2003.12.006
CHEMBL175348 60483 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 608 12 1 6 6.2 CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1F 10.1016/j.bmcl.2003.12.006
516246 61092 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 630 13 1 6 7.0 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC5CCC5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL176459 61092 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 630 13 1 6 7.0 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC5CCC5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516255 61302 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 622 13 1 6 6.6 CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1F 10.1016/j.bmcl.2003.12.006
CHEMBL176669 61302 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 622 13 1 6 6.6 CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1F 10.1016/j.bmcl.2003.12.006
516279 96532 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 652 11 1 6 7.8 CCn1nc(Cc2ccc(Oc3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL262402 96532 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 652 11 1 6 7.8 CCn1nc(Cc2ccc(Oc3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516230 128536 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 610 11 1 5 7.2 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4cccc5ccccc45)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL366611 128536 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 610 11 1 5 7.2 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4cccc5ccccc45)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516274 128750 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 616 11 1 6 6.6 CCn1nc(Cc2ccc(OC3CC3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL366873 128750 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 616 11 1 6 6.6 CCn1nc(Cc2ccc(OC3CC3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516221 132638 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 652 13 1 6 7.8 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(Oc5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL369812 132638 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 652 13 1 6 7.8 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(Oc5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516271 168360 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 604 11 1 6 6.4 CCOc1cccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)c1 10.1016/j.bmcl.2003.12.006
CHEMBL433793 168360 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 604 11 1 6 6.4 CCOc1cccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)c1 10.1016/j.bmcl.2003.12.006
20664161 79039 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 504 8 1 5 5.0 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccccn34)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2005.02.030
CHEMBL2113086 79039 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 504 8 1 5 5.0 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccccn34)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2005.02.030
3002977 2460 None 43 Human Binding pIC50 = 9.4 9.4 -1 2
Antagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 YU2-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assayAntagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 YU2-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/ml400370w
3002977.0 2460 None 43 Human Binding pIC50 = 9.4 9.4 -1 2
Antagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 YU2-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assayAntagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 YU2-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/ml400370w
803 2460 None 43 Human Binding pIC50 = 9.4 9.4 -1 2
Antagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 YU2-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assayAntagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 YU2-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/ml400370w
806 2460 None 43 Human Binding pIC50 = 9.4 9.4 -1 2
Antagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 YU2-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assayAntagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 YU2-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/ml400370w
CHEMBL1201187 2460 None 43 Human Binding pIC50 = 9.4 9.4 -1 2
Antagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 YU2-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assayAntagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 YU2-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/ml400370w
CHEMBL256907 2460 None 43 Human Binding pIC50 = 9.4 9.4 -1 2
Antagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 YU2-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assayAntagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 YU2-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/ml400370w
CHEMBL584744 2460 None 43 Human Binding pIC50 = 9.4 9.4 -1 2
Antagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 YU2-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assayAntagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 YU2-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/ml400370w
DB04835 2460 None 43 Human Binding pIC50 = 9.4 9.4 -1 2
Antagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 YU2-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assayAntagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 YU2-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assay
ChEMBL 513 8 1 5 6.0 O=C(C1CCC(CC1)(F)F)N[C@H](c1ccccc1)CCN1[C@@H]2CC[C@H]1CC(C2)n1c(C)nnc1C(C)C 10.1021/ml400370w
57391721 71087 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
ChEMBL 617 11 0 6 4.1 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cccc(C)c2)C2CCN(S(C)(=O)=O)CC2)CC1 10.1016/j.bmcl.2011.12.117
CHEMBL1951913 71087 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
ChEMBL 617 11 0 6 4.1 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cccc(C)c2)C2CCN(S(C)(=O)=O)CC2)CC1 10.1016/j.bmcl.2011.12.117
3009355 3989 None 18 Human Binding pIC50 = 9.4 9.4 - 1
Binding affinity to CCR5Binding affinity to CCR5
ChEMBL 533 6 0 6 4.5 COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F 10.1021/jm300682j
807 3989 None 18 Human Binding pIC50 = 9.4 9.4 - 1
Binding affinity to CCR5Binding affinity to CCR5
ChEMBL 533 6 0 6 4.5 COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F 10.1021/jm300682j
CHEMBL82301 3989 None 18 Human Binding pIC50 = 9.4 9.4 - 1
Binding affinity to CCR5Binding affinity to CCR5
ChEMBL 533 6 0 6 4.5 COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F 10.1021/jm300682j
DB06652 3989 None 18 Human Binding pIC50 = 9.4 9.4 - 1
Binding affinity to CCR5Binding affinity to CCR5
ChEMBL 533 6 0 6 4.5 COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F 10.1021/jm300682j
44590634 174909 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 543 10 1 3 6.0 CCN(C(=O)Cc1ccc(C(F)(F)F)cc1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 10.1016/j.bmcl.2009.01.009
CHEMBL456226 174909 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 543 10 1 3 6.0 CCN(C(=O)Cc1ccc(C(F)(F)F)cc1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 10.1016/j.bmcl.2009.01.009
44565080 187190 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 473 8 1 5 5.0 Cc1nnc(C(C)C)n1C1CCN([C@H](C)C[C@H](NC(=O)C2CC(F)(F)C2)c2ccccc2)CC1 10.1016/j.bmcl.2009.01.008
CHEMBL491319 187190 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 473 8 1 5 5.0 Cc1nnc(C(C)C)n1C1CCN([C@H](C)C[C@H](NC(=O)C2CC(F)(F)C2)c2ccccc2)CC1 10.1016/j.bmcl.2009.01.008
20672360 77347 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 534 10 1 3 6.4 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00829-6
CHEMBL20831 77347 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 534 10 1 3 6.4 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00829-6
20672386 98811 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 506 11 1 3 6.2 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00829-6
CHEMBL278085 98811 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 506 11 1 3 6.2 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00829-6
44273888 98822 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 558 11 1 4 5.5 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CC[S+]([O-])c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00829-6
CHEMBL278117 98822 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 558 11 1 4 5.5 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CC[S+]([O-])c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00829-6
44590440 179310 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 487 6 0 3 5.2 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)C(=O)C3CC3)CC2)CC1 10.1016/j.bmcl.2009.01.012
CHEMBL472464 179310 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 487 6 0 3 5.2 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3ccccc3)C(=O)C3CC3)CC2)CC1 10.1016/j.bmcl.2009.01.012
44357078 119465 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
ChEMBL 591 11 1 6 5.7 CCCN(c1ncc(C(F)(F)F)cn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/s0960-894x(02)00988-5
CHEMBL344641 119465 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
ChEMBL 591 11 1 6 5.7 CCCN(c1ncc(C(F)(F)F)cn1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/s0960-894x(02)00988-5
44401956 133647 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 572 8 1 5 6.3 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4c(Cl)cc(Cl)cn34)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2005.02.030
CHEMBL371177 133647 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 572 8 1 5 6.3 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4c(Cl)cc(Cl)cn34)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2005.02.030
20672386 98811 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 506 11 1 3 6.2 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL278085 98811 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 506 11 1 3 6.2 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
44565742 179226 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 548 11 1 3 6.8 CC(C)C[C@H](C(=O)O)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL471920 179226 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 548 11 1 3 6.8 CC(C)C[C@H](C(=O)O)N1C[C@H](CN2CCC(CCC(F)(F)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
10163007 95151 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
ChEMBL 482 5 0 4 6.0 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1 10.1016/j.bmcl.2008.01.108
CHEMBL255429 95151 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
ChEMBL 482 5 0 4 6.0 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1 10.1016/j.bmcl.2008.01.108
501046 109731 None 0 Human Binding pIC50 = 9.3 9.3 - 0
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
ChEMBL 518 10 2 4 5.6 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(O)(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/s0960-894x(02)00606-6
CHEMBL322603 109731 None 0 Human Binding pIC50 = 9.3 9.3 - 0
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
ChEMBL 518 10 2 4 5.6 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(O)(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/s0960-894x(02)00606-6
72714079 92730 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 565 8 1 4 6.1 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
CHEMBL2435886 92730 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 565 8 1 4 6.1 Cc1cc(Cl)nc(C)c1C(=O)NCC[C@H](C)N1CCC(N2C(=O)N(C3CCCCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
516311 59931 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 658 11 1 6 7.7 CCn1nc(Cc2ccc(OC(C)(C)C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL173091 59931 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 658 11 1 6 7.7 CCn1nc(Cc2ccc(OC(C)(C)C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516312 60022 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 678 12 1 6 8.4 CCn1nc(Cc2ccc(Oc3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL173479 60022 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 678 12 1 6 8.4 CCn1nc(Cc2ccc(Oc3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516192 60049 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 618 14 1 6 6.8 CCCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 10.1016/j.bmcl.2003.12.006
CHEMBL173583 60049 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 618 14 1 6 6.8 CCCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 10.1016/j.bmcl.2003.12.006
516282 60425 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 626 11 1 6 6.6 CCn1nc(Cc2ccc(OC(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL174996 60425 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 626 11 1 6 6.6 CCn1nc(Cc2ccc(OC(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516228 60440 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 615 12 1 7 5.9 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC)c(C#N)c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL175079 60440 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 615 12 1 7 5.9 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC)c(C#N)c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516227 60481 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 604 11 1 7 5.8 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc5c(c4)OCO5)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL175341 60481 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 604 11 1 7 5.8 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc5c(c4)OCO5)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516313 61152 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 602 10 2 6 6.3 CCn1nc(Cc2ccc(O)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL176528 61152 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 602 10 2 6 6.3 CCn1nc(Cc2ccc(O)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
44385583 61520 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 578 9 1 5 6.2 CCn1nc(Cc2ccccc2F)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL177071 61520 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 578 9 1 5 6.2 CCn1nc(Cc2ccccc2F)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516251 96945 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 658 13 1 6 7.0 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OCC(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL265723 96945 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 658 13 1 6 7.0 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OCC(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516205 128535 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 628 11 1 5 7.0 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL366610 128535 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 628 11 1 5 7.0 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516259 129798 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 636 12 1 5 7.7 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(-c5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL367416 129798 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 636 12 1 5 7.7 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(-c5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
44384782 130262 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 589 12 2 6 6.1 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4cccc(NC)c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL367897 130262 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 589 12 2 6 6.1 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4cccc(NC)c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516248 130353 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 666 14 1 6 7.6 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OCc5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL368000 130353 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 666 14 1 6 7.6 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OCc5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516198 131892 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 612 12 1 6 6.2 CCn1nc(Cc2ccc(OC(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL369398 131892 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 612 12 1 6 6.2 CCn1nc(Cc2ccc(OC(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516237 131969 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 628 11 1 5 7.0 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL369478 131969 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 628 11 1 5 7.0 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516249 132176 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 652 13 1 6 7.8 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(Oc5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL369593 132176 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 652 13 1 6 7.8 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(Oc5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
3010272 189561 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 517 9 1 5 5.7 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL513564 189561 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 517 9 1 5 5.7 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
3010272 189561 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 517 9 1 5 5.7 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2004.04.078
CHEMBL513564 189561 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 517 9 1 5 5.7 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2004.04.078
3010272 189561 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 517 9 1 5 5.7 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL513564 189561 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 517 9 1 5 5.7 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)s3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
44564930 179470 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 465 8 1 5 5.6 Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CCCCC2)c2ccccc2)CC1 10.1016/j.bmcl.2009.01.008
CHEMBL473759 179470 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 465 8 1 5 5.6 Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CCCCC2)c2ccccc2)CC1 10.1016/j.bmcl.2009.01.008
57391722 71089 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
ChEMBL 637 11 0 6 4.4 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cccc(Cl)c2)C2CCN(S(C)(=O)=O)CC2)CC1 10.1016/j.bmcl.2011.12.117
CHEMBL1951917 71089 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
ChEMBL 637 11 0 6 4.4 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cccc(Cl)c2)C2CCN(S(C)(=O)=O)CC2)CC1 10.1016/j.bmcl.2011.12.117
44565761 188424 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 554 11 2 4 6.1 CCc1nc(Cc2ccccc2)[nH]c1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1 10.1016/j.ejmech.2008.01.040
CHEMBL500631 188424 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 554 11 2 4 6.1 CCc1nc(Cc2ccccc2)[nH]c1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1 10.1016/j.ejmech.2008.01.040
3010275 78750 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 572 11 2 4 6.2 CCc1[nH]c(Cc2ccccc2)nc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2004.04.078
CHEMBL2112558 78750 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 572 11 2 4 6.2 CCc1[nH]c(Cc2ccccc2)nc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2004.04.078
44565761 188424 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 554 11 2 4 6.1 CCc1nc(Cc2ccccc2)[nH]c1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1 10.1016/j.ejmech.2008.01.040
CHEMBL500631 188424 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 554 11 2 4 6.1 CCc1nc(Cc2ccccc2)[nH]c1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1 10.1016/j.ejmech.2008.01.040
44565762 179301 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 560 10 2 4 6.2 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3[nH]c(Cc4ccccc4)nc3Cl)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL472412 179301 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 560 10 2 4 6.2 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3[nH]c(Cc4ccccc4)nc3Cl)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
44401965 71342 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 549 9 1 7 4.9 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccc([N+](=O)[O-])cn34)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2005.02.030
CHEMBL195753 71342 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 549 9 1 7 4.9 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccc([N+](=O)[O-])cn34)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2005.02.030
44565762 179301 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 560 10 2 4 6.2 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3[nH]c(Cc4ccccc4)nc3Cl)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL472412 179301 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 560 10 2 4 6.2 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3[nH]c(Cc4ccccc4)nc3Cl)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
3008904 202422 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
ChEMBL 537 6 0 5 5.0 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3cccc(C#N)c3)c3ccccc3)CC2)CC1 10.1016/j.bmcl.2008.01.108
CHEMBL59511 202422 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
ChEMBL 537 6 0 5 5.0 Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCC(N(Cc3cccc(C#N)c3)c3ccccc3)CC2)CC1 10.1016/j.bmcl.2008.01.108
58834906 92697 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 604 8 1 6 6.2 Cc1nc(Oc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2cccc(Cl)c2)CC1 10.1021/jm401101p
CHEMBL2435853 92697 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 604 8 1 6 6.2 Cc1nc(Oc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2cccc(Cl)c2)CC1 10.1021/jm401101p
3010276 78749 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 578 10 2 4 6.3 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3[nH]c(Cc4ccccc4)nc3Cl)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2004.04.078
CHEMBL2112557 78749 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 578 10 2 4 6.3 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3[nH]c(Cc4ccccc4)nc3Cl)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2004.04.078
516337 130247 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of human CX3C chemokine receptor 5 from GP120-membrane-based assayInhibition of human CX3C chemokine receptor 5 from GP120-membrane-based assay
ChEMBL 596 12 1 5 7.0 CCCn1ncc(CCc2ccccc2)c1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/j.bmcl.2003.12.004
CHEMBL367837 130247 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of human CX3C chemokine receptor 5 from GP120-membrane-based assayInhibition of human CX3C chemokine receptor 5 from GP120-membrane-based assay
ChEMBL 596 12 1 5 7.0 CCCn1ncc(CCc2ccccc2)c1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/j.bmcl.2003.12.004
516333 120404 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory activity against human CC chemokine receptor 5Inhibitory activity against human CC chemokine receptor 5
ChEMBL 582 11 1 5 6.6 CCn1ncc(CCc2ccccc2)c1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/j.bmcl.2003.12.004
CHEMBL352981 120404 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory activity against human CC chemokine receptor 5Inhibitory activity against human CC chemokine receptor 5
ChEMBL 582 11 1 5 6.6 CCn1ncc(CCc2ccccc2)c1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/j.bmcl.2003.12.004
516293 59716 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 636 10 1 5 7.7 CCn1nc(Cc2ccc(-c3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL172296 59716 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 636 10 1 5 7.7 CCn1nc(Cc2ccc(-c3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516194 59970 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 616 12 1 6 6.6 CCn1nc(Cc2ccc(OC3CCC3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL173254 59970 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 616 12 1 6 6.6 CCn1nc(Cc2ccc(OC3CCC3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516280 61087 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 644 10 1 6 6.9 CCn1nc(Cc2ccc(OC(F)(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL176426 61087 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 644 10 1 6 6.9 CCn1nc(Cc2ccc(OC(F)(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516223 61398 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 658 13 1 6 7.0 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OCC(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL176933 61398 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 658 13 1 6 7.0 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OCC(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516199 96569 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 562 10 2 6 5.3 CCn1nc(Cc2ccc(O)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL262663 96569 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 562 10 2 6 5.3 CCn1nc(Cc2ccc(O)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516291 96690 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 602 10 1 5 7.2 CCn1nc(Cc2ccc(C(C)C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL263529 96690 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 602 10 1 5 7.2 CCn1nc(Cc2ccc(C(C)C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516252 129888 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 626 13 1 6 6.6 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL367560 129888 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 626 13 1 6 6.6 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516212 130152 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 604 13 1 6 6.4 CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 10.1016/j.bmcl.2003.12.006
CHEMBL367700 130152 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 604 13 1 6 6.4 CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 10.1016/j.bmcl.2003.12.006
516209 130782 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 700 13 1 7 6.9 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(S(=O)(=O)c5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL368467 130782 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 700 13 1 7 6.9 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(S(=O)(=O)c5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516290 131997 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 574 9 1 5 6.3 CCn1nc(Cc2ccc(C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL369494 131997 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 574 9 1 5 6.3 CCn1nc(Cc2ccc(C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516250 132200 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 644 12 1 6 6.9 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL369659 132200 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 644 12 1 6 6.9 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC(F)(F)F)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516253 158300 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 576 11 2 6 5.7 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(O)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL408800 158300 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 576 11 2 6 5.7 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(O)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516196 166177 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 638 12 1 6 7.4 CCn1nc(Cc2ccc(Oc3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL425845 166177 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 638 12 1 6 7.4 CCn1nc(Cc2ccc(Oc3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516281 166393 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 658 11 1 6 7.0 CCn1nc(Cc2ccc(OCC(F)(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL427122 166393 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 658 11 1 6 7.0 CCn1nc(Cc2ccc(OCC(F)(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
3010261 192492 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 540 9 2 4 5.9 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)[nH]3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL520755 192492 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 540 9 2 4 5.9 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)[nH]3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
3010261 192492 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 540 9 2 4 5.9 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)[nH]3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL520755 192492 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 540 9 2 4 5.9 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)[nH]3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
3010261 192492 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 540 9 2 4 5.9 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)[nH]3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2004.04.078
CHEMBL520755 192492 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 540 9 2 4 5.9 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cnc(Cc4ccccc4)[nH]3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2004.04.078
57403932 71086 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
ChEMBL 621 11 0 6 3.9 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cccc(F)c2)C2CCN(S(C)(=O)=O)CC2)CC1 10.1016/j.bmcl.2011.12.117
CHEMBL1951912 71086 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
ChEMBL 621 11 0 6 3.9 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cccc(F)c2)C2CCN(S(C)(=O)=O)CC2)CC1 10.1016/j.bmcl.2011.12.117
57396952 71088 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
ChEMBL 655 11 0 6 4.6 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cc(F)cc(Cl)c2)C2CCN(S(C)(=O)=O)CC2)CC1 10.1016/j.bmcl.2011.12.117
CHEMBL1951915 71088 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
ChEMBL 655 11 0 6 4.6 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2cc(F)cc(Cl)c2)C2CCN(S(C)(=O)=O)CC2)CC1 10.1016/j.bmcl.2011.12.117
501056 107528 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 462 10 1 3 5.5 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL318406 107528 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 462 10 1 3 5.5 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
501056 107528 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 462 10 1 3 5.5 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL318406 107528 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 462 10 1 3 5.5 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
3008917 205241 None 3 Crab-eating macaque Binding pIC50 = 9.2 9.2 - 0
Displacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cellsDisplacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cells
ChEMBL 481 5 0 3 6.6 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1016/j.bmcl.2008.01.108
CHEMBL62152 205241 None 3 Crab-eating macaque Binding pIC50 = 9.2 9.2 - 0
Displacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cellsDisplacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cells
ChEMBL 481 5 0 3 6.6 Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3ccccc3)CC2)CC1 10.1016/j.bmcl.2008.01.108
501056 107528 None 0 Human Binding pIC50 = 9.2 9.2 - 0
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
ChEMBL 462 10 1 3 5.5 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/s0960-894x(02)00606-6
CHEMBL318406 107528 None 0 Human Binding pIC50 = 9.2 9.2 - 0
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
ChEMBL 462 10 1 3 5.5 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/s0960-894x(02)00606-6
58835217 92700 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 584 9 1 6 5.8 CCc1nc(Oc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
CHEMBL2435856 92700 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 584 9 1 6 5.8 CCc1nc(Oc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
44415755 138786 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of [125I]MIP-1beta binding to CCR5 expressed in HEK293 cellsInhibition of [125I]MIP-1beta binding to CCR5 expressed in HEK293 cells
ChEMBL 451 9 2 3 4.0 O=C(Cc1ccc(F)cc1)NC1CCN(CC[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 10.1016/j.bmcl.2006.06.012
CHEMBL377914 138786 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of [125I]MIP-1beta binding to CCR5 expressed in HEK293 cellsInhibition of [125I]MIP-1beta binding to CCR5 expressed in HEK293 cells
ChEMBL 451 9 2 3 4.0 O=C(Cc1ccc(F)cc1)NC1CCN(CC[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 10.1016/j.bmcl.2006.06.012
3010279 78744 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 564 10 2 4 5.9 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(c3[nH]c(Cc4ccccc4)nc3Cl)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2004.04.078
CHEMBL2112552 78744 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 564 10 2 4 5.9 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(c3[nH]c(Cc4ccccc4)nc3Cl)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2004.04.078
516285 59724 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 604 9 1 7 5.8 CCn1nc(Cc2ccc3c(c2)OCO3)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL172322 59724 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 604 9 1 7 5.8 CCn1nc(Cc2ccc3c(c2)OCO3)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516229 59983 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 622 13 1 6 6.6 CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1F 10.1016/j.bmcl.2003.12.006
CHEMBL173308 59983 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 622 13 1 6 6.6 CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1F 10.1016/j.bmcl.2003.12.006
516308 60488 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 644 13 1 6 7.4 CCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C5CCCCC5)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 10.1016/j.bmcl.2003.12.006
CHEMBL175394 60488 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 644 13 1 6 7.4 CCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C5CCCCC5)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 10.1016/j.bmcl.2003.12.006
516275 61453 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 630 11 1 6 7.0 CCn1nc(Cc2ccc(OC3CCC3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL177033 61453 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 630 11 1 6 7.0 CCn1nc(Cc2ccc(OC3CCC3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516220 62142 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 666 14 1 6 7.6 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OCc5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL177648 62142 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 666 14 1 6 7.6 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OCc5ccccc5)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516287 120056 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 622 11 1 6 6.6 CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1F 10.1016/j.bmcl.2003.12.006
CHEMBL349974 120056 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 622 11 1 6 6.6 CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1F 10.1016/j.bmcl.2003.12.006
516276 130729 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 618 11 1 6 6.8 CCn1nc(Cc2ccc(OC(C)C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL368204 130729 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 618 11 1 6 6.8 CCn1nc(Cc2ccc(OC(C)C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516269 168647 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 590 10 1 6 6.0 CCn1nc(Cc2cccc(OC)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL435554 168647 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 590 10 1 6 6.0 CCn1nc(Cc2cccc(OC)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
3010267 78752 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 512 10 2 4 5.1 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(c3c[nH]c(Cc4ccccc4)n3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2004.04.078
CHEMBL2112560 78752 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 512 10 2 4 5.1 O=C(O)[C@@H](CC1CC1)N1C[C@H](CN2CCC(c3c[nH]c(Cc4ccccc4)n3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2004.04.078
44461741 168156 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
ChEMBL 619 14 1 6 5.3 C=CCN(C(=O)NCc1ccc([N+](=O)[O-])cc1)C1CCN(CC[C@@H](CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1 10.1016/s0960-894x(01)00492-9
CHEMBL432360 168156 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
ChEMBL 619 14 1 6 5.3 C=CCN(C(=O)NCc1ccc([N+](=O)[O-])cc1)C1CCN(CC[C@@H](CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1 10.1016/s0960-894x(01)00492-9
76330829 85648 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
ChEMBL 605 13 1 6 5.6 C=CCN(C(=O)Nc1ccc([N+](=O)[O-])cc1)C1CCN(CCC(CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1 10.1007/s00044-012-0138-3
CHEMBL2282506 85648 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
ChEMBL 605 13 1 6 5.6 C=CCN(C(=O)Nc1ccc([N+](=O)[O-])cc1)C1CCN(CCC(CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1 10.1007/s00044-012-0138-3
16073660 79809 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
ChEMBL 596 11 0 6 4.6 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2ccccc2)c2ccc(S(C)(=O)=O)cc2)CC1 10.1016/j.bmcl.2006.03.089
CHEMBL211866 79809 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
ChEMBL 596 11 0 6 4.6 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@@H](c2ccccc2)c2ccc(S(C)(=O)=O)cc2)CC1 10.1016/j.bmcl.2006.03.089
44565853 179139 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 571 11 1 5 6.8 CCc1nc(Cc2ccccc2)sc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1 10.1016/j.ejmech.2008.01.040
CHEMBL471251 179139 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 571 11 1 5 6.8 CCc1nc(Cc2ccccc2)sc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1 10.1016/j.ejmech.2008.01.040
3010278 78745 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 589 11 1 5 7.0 CCc1nc(Cc2ccccc2)sc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2004.04.078
CHEMBL2112553 78745 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 589 11 1 5 7.0 CCc1nc(Cc2ccccc2)sc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2004.04.078
44565853 179139 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 571 11 1 5 6.8 CCc1nc(Cc2ccccc2)sc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1 10.1016/j.ejmech.2008.01.040
CHEMBL471251 179139 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 571 11 1 5 6.8 CCc1nc(Cc2ccccc2)sc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1 10.1016/j.ejmech.2008.01.040
76327166 85651 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
ChEMBL 620 14 1 6 5.1 CCCN(C(=O)OCc1cccc(C(N)=O)c1)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1 10.1007/s00044-012-0138-3
CHEMBL2282509 85651 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
ChEMBL 620 14 1 6 5.1 CCCN(C(=O)OCc1cccc(C(N)=O)c1)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2ccccc2)CC1 10.1007/s00044-012-0138-3
501051 4489 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 512 10 2 4 5.4 O=C(O)[C@@H](c1ccccc1)N1C[C@H](CN2CCC(O)(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL101961 4489 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 512 10 2 4 5.4 O=C(O)[C@@H](c1ccccc1)N1C[C@H](CN2CCC(O)(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
516260 59861 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 560 9 1 5 6.0 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.ejmech.2008.01.040
CHEMBL172854 59861 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 560 9 1 5 6.0 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.ejmech.2008.01.040
44273960 99279 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 524 11 1 3 6.4 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL281607 99279 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 524 11 1 3 6.4 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
44565719 179224 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 530 11 1 4 6.4 CC(C)C[C@H](C(=O)O)N1C[C@H](CN2CCC(CCSc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL471909 179224 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 530 11 1 4 6.4 CC(C)C[C@H](C(=O)O)N1C[C@H](CN2CCC(CCSc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
516342 189349 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 541 9 1 5 6.2 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)no3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL511634 189349 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 541 9 1 5 6.2 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)no3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
44274108 99208 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 516 10 1 4 6.0 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCSc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00829-6
CHEMBL281176 99208 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 516 10 1 4 6.0 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCSc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00829-6
44273960 99279 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 524 11 1 3 6.4 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00829-6
CHEMBL281607 99279 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 524 11 1 3 6.4 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00829-6
490022 111657 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Ability to displace [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesAbility to displace [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 588 10 0 6 6.0 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(01)00835-6
CHEMBL328260 111657 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Ability to displace [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesAbility to displace [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 588 10 0 6 6.0 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(01)00835-6
44357072 98545 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
ChEMBL 553 12 1 7 4.7 CCCN(c1nccc(OC)n1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/s0960-894x(02)00988-5
CHEMBL275998 98545 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
ChEMBL 553 12 1 7 4.7 CCCN(c1nccc(OC)n1)C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/s0960-894x(02)00988-5
490020 111666 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
ChEMBL 616 10 0 6 6.4 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)c3ccccc3Cl)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00988-5
CHEMBL328297 111666 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
ChEMBL 616 10 0 6 6.4 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)c3ccccc3Cl)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00988-5
20664149 69868 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 580 9 1 5 6.7 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccc(-c5ccccc5)cn34)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2005.02.030
CHEMBL193822 69868 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 580 9 1 5 6.7 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccc(-c5ccccc5)cn34)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2005.02.030
516260 59861 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
ChEMBL 560 9 1 5 6.0 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.005
CHEMBL172854 59861 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
ChEMBL 560 9 1 5 6.0 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.005
516236 168646 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
ChEMBL 560 11 1 5 6.0 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.005
CHEMBL435538 168646 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
ChEMBL 560 11 1 5 6.0 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.005
490020 111666 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 616 10 0 6 6.4 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)c3ccccc3Cl)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00605-4
CHEMBL328297 111666 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 616 10 0 6 6.4 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)c3ccccc3Cl)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00605-4
501051 4489 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 512 10 2 4 5.4 O=C(O)[C@@H](c1ccccc1)N1C[C@H](CN2CCC(O)(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL101961 4489 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 512 10 2 4 5.4 O=C(O)[C@@H](c1ccccc1)N1C[C@H](CN2CCC(O)(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
516260 59861 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 560 9 1 5 6.0 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.ejmech.2008.01.040
CHEMBL172854 59861 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 560 9 1 5 6.0 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.ejmech.2008.01.040
44273960 99279 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 524 11 1 3 6.4 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL281607 99279 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 524 11 1 3 6.4 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(CCCc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
44565719 179224 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 530 11 1 4 6.4 CC(C)C[C@H](C(=O)O)N1C[C@H](CN2CCC(CCSc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL471909 179224 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 530 11 1 4 6.4 CC(C)C[C@H](C(=O)O)N1C[C@H](CN2CCC(CCSc3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
516342 189349 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 541 9 1 5 6.2 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)no3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL511634 189349 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 541 9 1 5 6.2 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)no3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2008.01.040
44447734 95192 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
ChEMBL 523 5 0 5 6.1 CC1(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CCN(C(=O)c2c(Cl)cncc2Cl)CC1 10.1016/j.bmcl.2008.01.108
CHEMBL255644 95192 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
ChEMBL 523 5 0 5 6.1 CC1(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CCN(C(=O)c2c(Cl)cncc2Cl)CC1 10.1016/j.bmcl.2008.01.108
10413034 95233 None 0 Crab-eating macaque Binding pIC50 = 9.1 9.1 - 0
Displacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cellsDisplacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cells
ChEMBL 483 5 0 5 5.4 Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1 10.1016/j.bmcl.2008.01.108
CHEMBL255856 95233 None 0 Crab-eating macaque Binding pIC50 = 9.1 9.1 - 0
Displacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cellsDisplacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cells
ChEMBL 483 5 0 5 5.4 Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1 10.1016/j.bmcl.2008.01.108
501051 4489 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
ChEMBL 512 10 2 4 5.4 O=C(O)[C@@H](c1ccccc1)N1C[C@H](CN2CCC(O)(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/s0960-894x(02)00606-6
CHEMBL101961 4489 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
ChEMBL 512 10 2 4 5.4 O=C(O)[C@@H](c1ccccc1)N1C[C@H](CN2CCC(O)(CCCc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/s0960-894x(02)00606-6
486605 104419 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
ChEMBL 654 14 1 6 5.7 CCCN(C(=O)OCc1cccc(C(N)=O)c1)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2cccc(Cl)c2)CC1 10.1016/s0960-894x(01)00492-9
CHEMBL310106 104419 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
ChEMBL 654 14 1 6 5.7 CCCN(C(=O)OCc1cccc(C(N)=O)c1)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2cccc(Cl)c2)CC1 10.1016/s0960-894x(01)00492-9
486605 104419 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of human CCR5 in PBMC cellInhibition of human CCR5 in PBMC cell
ChEMBL 654 14 1 6 5.7 CCCN(C(=O)OCc1cccc(C(N)=O)c1)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b01309
CHEMBL310106 104419 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of human CCR5 in PBMC cellInhibition of human CCR5 in PBMC cell
ChEMBL 654 14 1 6 5.7 CCCN(C(=O)OCc1cccc(C(N)=O)c1)C1CCN(CC[C@H](CN(C)S(=O)(=O)c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b01309
44384927 168665 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory activity against human CC chemokine receptor 5Inhibitory activity against human CC chemokine receptor 5
ChEMBL 541 9 1 5 6.2 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3oncc3Cc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2003.12.004
CHEMBL435709 168665 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory activity against human CC chemokine receptor 5Inhibitory activity against human CC chemokine receptor 5
ChEMBL 541 9 1 5 6.2 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(c3oncc3Cc3ccccc3)CC2)[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2003.12.004
516197 59642 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 630 11 1 6 6.5 CCn1nc(Cc2ccc(OC(F)(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL172013 59642 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 630 11 1 6 6.5 CCn1nc(Cc2ccc(OC(F)(F)F)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516309 59726 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 658 14 1 6 7.7 CCCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C5CCCCC5)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 10.1016/j.bmcl.2003.12.006
CHEMBL172327 59726 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 658 14 1 6 7.7 CCCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C5CCCCC5)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 10.1016/j.bmcl.2003.12.006
516260 59861 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 560 9 1 5 6.0 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL172854 59861 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 560 9 1 5 6.0 CCn1nc(Cc2ccccc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516273 60492 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 632 13 1 6 7.2 CCCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 10.1016/j.bmcl.2003.12.006
CHEMBL175424 60492 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 632 13 1 6 7.2 CCCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 10.1016/j.bmcl.2003.12.006
516218 61285 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 618 13 1 6 6.8 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC(C)C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL176624 61285 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 618 13 1 6 6.8 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(OC(C)C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516244 61748 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 632 15 1 6 7.2 CCCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 10.1016/j.bmcl.2003.12.006
CHEMBL177168 61748 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 632 15 1 6 7.2 CCCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 10.1016/j.bmcl.2003.12.006
516195 61787 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 618 11 1 6 6.8 CCn1nc(Cc2ccc(OC(C)(C)C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL177204 61787 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 618 11 1 6 6.8 CCn1nc(Cc2ccc(OC(C)(C)C)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516242 96713 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 604 13 1 6 6.4 CCOc1cccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)c1 10.1016/j.bmcl.2003.12.006
CHEMBL263787 96713 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 604 13 1 6 6.4 CCOc1cccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)c1 10.1016/j.bmcl.2003.12.006
516304 120560 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 726 12 1 7 7.4 CCn1nc(Cc2ccc(S(=O)(=O)c3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL354413 120560 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 726 12 1 7 7.4 CCn1nc(Cc2ccc(S(=O)(=O)c3ccccc3)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516272 120892 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 618 12 1 6 6.8 CCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 10.1016/j.bmcl.2003.12.006
CHEMBL355809 120892 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 618 12 1 6 6.8 CCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 10.1016/j.bmcl.2003.12.006
516200 128122 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 601 11 1 7 5.5 CCn1nc(Cc2ccc(OC)c(C#N)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL366492 128122 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 601 11 1 7 5.5 CCn1nc(Cc2ccc(OC)c(C#N)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516258 128589 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 616 11 1 5 7.3 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C(C)(C)C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL366742 128589 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 616 11 1 5 7.3 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccc(C(C)(C)C)cc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516191 131684 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 604 13 1 6 6.4 CCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 10.1016/j.bmcl.2003.12.006
CHEMBL369278 131684 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 604 13 1 6 6.4 CCCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 10.1016/j.bmcl.2003.12.006
44325665 111465 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
ChEMBL 632 10 0 6 6.9 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)c3cccc4ccccc34)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(01)00545-5
CHEMBL327241 111465 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
ChEMBL 632 10 0 6 6.9 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)c3cccc4ccccc34)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(01)00545-5
490022 111657 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
ChEMBL 588 10 0 6 6.0 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(01)00545-5
CHEMBL328260 111657 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
ChEMBL 588 10 0 6 6.0 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)C3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(01)00545-5
490020 111666 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
ChEMBL 616 10 0 6 6.4 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)c3ccccc3Cl)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(01)00545-5
CHEMBL328297 111666 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
ChEMBL 616 10 0 6 6.4 C=CCN(C(=O)OCc1ccc([N+](=O)[O-])cc1)C1CCN(C[C@H]2CN(C(=O)c3ccccc3Cl)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(01)00545-5
44401760 168689 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 572 8 1 5 6.0 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccc(C(F)(F)F)cn34)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2005.02.030
CHEMBL435886 168689 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 572 8 1 5 6.0 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccc(C(F)(F)F)cn34)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2005.02.030
44565037 193093 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 501 8 1 5 5.8 Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CCC(F)(F)CC2)c2ccccc2)CC1 10.1016/j.bmcl.2009.01.008
CHEMBL489324 193093 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 501 8 1 5 5.8 Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CCC(F)(F)CC2)c2ccccc2)CC1 10.1016/j.bmcl.2009.01.008
CHEMBL522259 193093 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 501 8 1 5 5.8 Cc1nnc(C(C)C)n1C1CCN(C(C)C[C@H](NC(=O)C2CCC(F)(F)CC2)c2ccccc2)CC1 10.1016/j.bmcl.2009.01.008
20672384 69606 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 542 10 1 5 6.3 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(CCCn3cnc4ccccc43)CC2)[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2005.02.030
CHEMBL193440 69606 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 542 10 1 5 6.3 O=C(O)[C@@H](C1CCCCC1)N1C[C@H](CN2CCC(CCCn3cnc4ccccc43)CC2)[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2005.02.030
44565852 172764 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 555 11 1 5 6.4 CCc1nc(Cc2ccccc2)oc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1 10.1016/j.ejmech.2008.01.040
CHEMBL449758 172764 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 555 11 1 5 6.4 CCc1nc(Cc2ccccc2)oc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1 10.1016/j.ejmech.2008.01.040
44401751 70101 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 538 8 1 5 5.7 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccc(Cl)cn34)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2005.02.030
CHEMBL193988 70101 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 538 8 1 5 5.7 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4ccc(Cl)cn34)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2005.02.030
44565852 172764 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 555 11 1 5 6.4 CCc1nc(Cc2ccccc2)oc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1 10.1016/j.ejmech.2008.01.040
CHEMBL449758 172764 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 555 11 1 5 6.4 CCc1nc(Cc2ccccc2)oc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2ccccc2)CC1 10.1016/j.ejmech.2008.01.040
3010277 78748 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 573 11 1 5 6.5 CCc1nc(Cc2ccccc2)oc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2004.04.078
CHEMBL2112556 78748 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
ChEMBL 573 11 1 5 6.5 CCc1nc(Cc2ccccc2)oc1C1CCN(C[C@H]2CN([C@H](CC3CCC3)C(=O)O)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2004.04.078
516366 168668 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 574 12 1 5 6.4 CCC(CC)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL435727 168668 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 574 12 1 5 6.4 CCC(CC)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
44565718 179065 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 562 11 1 5 5.1 CC(C)C[C@H](C(=O)O)N1C[C@H](CN2CCC(CCS(=O)(=O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL470510 179065 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 562 11 1 5 5.1 CC(C)C[C@H](C(=O)O)N1C[C@H](CN2CCC(CCS(=O)(=O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
44274106 76550 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 548 10 1 5 4.7 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCS(=O)(=O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00829-6
CHEMBL20602 76550 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
ChEMBL 548 10 1 5 4.7 CC(C)[C@H](C(=O)O)N1C[C@H](CN2CCC(CCS(=O)(=O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/s0960-894x(02)00829-6
516203 60357 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
ChEMBL 560 11 1 5 6.0 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.005
CHEMBL174457 60357 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
ChEMBL 560 11 1 5 6.0 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.005
516366 168668 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
ChEMBL 574 12 1 5 6.4 CCC(CC)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.005
CHEMBL435727 168668 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
ChEMBL 574 12 1 5 6.4 CCC(CC)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.005
44205000 170298 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP-1beta from CCR5 expressed in CHO cell membraneDisplacement of [125I]MIP-1beta from CCR5 expressed in CHO cell membrane
ChEMBL 594 8 0 6 7.0 COC(=O)C(c1ccc(F)cc1)N1CCC(CCN2[C@H]3CC[C@@H]2C[C@H](n2c(C)nc4ccccc42)C3)(c2ccccc2)CC1 10.1016/j.bmcl.2009.02.014
CHEMBL444497 170298 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP-1beta from CCR5 expressed in CHO cell membraneDisplacement of [125I]MIP-1beta from CCR5 expressed in CHO cell membrane
ChEMBL 594 8 0 6 7.0 COC(=O)C(c1ccc(F)cc1)N1CCC(CCN2[C@H]3CC[C@@H]2C[C@H](n2c(C)nc4ccccc42)C3)(c2ccccc2)CC1 10.1016/j.bmcl.2009.02.014
516366 168668 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 574 12 1 5 6.4 CCC(CC)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL435727 168668 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 574 12 1 5 6.4 CCC(CC)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
44565718 179065 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 562 11 1 5 5.1 CC(C)C[C@H](C(=O)O)N1C[C@H](CN2CCC(CCS(=O)(=O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
CHEMBL470510 179065 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 562 11 1 5 5.1 CC(C)C[C@H](C(=O)O)N1C[C@H](CN2CCC(CCS(=O)(=O)c3ccc(F)cc3)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.ejmech.2008.01.040
10413034 95233 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
ChEMBL 483 5 0 5 5.4 Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1 10.1016/j.bmcl.2008.01.108
CHEMBL255856 95233 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
ChEMBL 483 5 0 5 5.4 Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCC(N(c3ccccc3)c3cccnc3)CC2)CC1 10.1016/j.bmcl.2008.01.108
16041411 92628 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 572 8 1 6 5.6 O=C(O)c1ccc(Sc2ccc(CN3CCC(N4C(=O)N(C5CCOCC5)C[C@H]4c4ccccc4)CC3)cn2)cc1 10.1021/jm401101p
CHEMBL2434978 92628 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 572 8 1 6 5.6 O=C(O)c1ccc(Sc2ccc(CN3CCC(N4C(=O)N(C5CCOCC5)C[C@H]4c4ccccc4)CC3)cn2)cc1 10.1021/jm401101p
58835113 92688 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 607 8 1 7 5.6 O=C(O)c1ccc(Sc2ncc(CN3CCC(N4C(=O)N(C5CCOCC5)C[C@H]4c4cccc(Cl)c4)CC3)cn2)cc1 10.1021/jm401101p
CHEMBL2435844 92688 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 607 8 1 7 5.6 O=C(O)c1ccc(Sc2ncc(CN3CCC(N4C(=O)N(C5CCOCC5)C[C@H]4c4cccc(Cl)c4)CC3)cn2)cc1 10.1021/jm401101p
58834946 92689 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 604 8 2 7 5.5 Cc1nc(Nc2ccc(C(=O)O)cc2)ncc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2cccc(Cl)c2)CC1 10.1021/jm401101p
CHEMBL2435845 92689 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 604 8 2 7 5.5 Cc1nc(Nc2ccc(C(=O)O)cc2)ncc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2cccc(Cl)c2)CC1 10.1021/jm401101p
72711741 92703 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 579 9 1 4 6.4 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(CC3CCCCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
CHEMBL2435859 92703 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 579 9 1 4 6.4 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(CC3CCCCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
72711739 92751 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 551 8 1 4 5.7 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
CHEMBL2435907 92751 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 551 8 1 4 5.7 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCC3)C[C@H]2c2ccccc2)CC1 10.1021/jm401101p
59458247 92756 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 571 8 1 5 6.2 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccsc2)CC1 10.1021/jm401101p
CHEMBL2435912 92756 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
ChEMBL 571 8 1 5 6.2 Cc1cc(Cl)nc(C)c1C(=O)NCCC(C)N1CCC(N2C(=O)N(C3CCCCC3)CC2c2ccsc2)CC1 10.1021/jm401101p
516208 59518 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 585 11 1 6 5.9 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4cccc(C#N)c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL171468 59518 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 585 11 1 6 5.9 CC[C@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4cccc(C#N)c4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
516286 60415 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 615 10 1 7 5.9 CCn1nc(Cc2ccc(OC)c(C#N)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL174904 60415 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 615 10 1 7 5.9 CCn1nc(Cc2ccc(OC)c(C#N)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516270 61245 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 604 11 1 6 6.4 CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 10.1016/j.bmcl.2003.12.006
CHEMBL176604 61245 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 604 11 1 6 6.4 CCOc1ccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)C(C)(C)C)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)cc1 10.1016/j.bmcl.2003.12.006
516300 128531 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 620 10 1 5 7.2 CCn1nc(Cc2ccc(Cl)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL366600 128531 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 620 10 1 5 7.2 CCn1nc(Cc2ccc(Cl)cc2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516213 129393 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 604 13 1 6 6.4 CCOc1cccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)c1 10.1016/j.bmcl.2003.12.006
CHEMBL367102 129393 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 604 13 1 6 6.4 CCOc1cccc(Cc2cc(C3CCN(C[C@H]4CN([C@@H](C(=O)O)[C@@H](C)CC)C[C@@H]4c4cccc(F)c4)CC3)n(CC)n2)c1 10.1016/j.bmcl.2003.12.006
516298 130752 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 622 10 1 5 6.8 CCn1nc(Cc2cc(F)cc(F)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
CHEMBL368332 130752 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 622 10 1 5 6.8 CCn1nc(Cc2cc(F)cc(F)c2)cc1C1CCN(C[C@H]2CN([C@@H](C(=O)O)C3CCCCC3)C[C@@H]2c2cccc(F)c2)CC1 10.1016/j.bmcl.2003.12.006
516236 168646 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 560 11 1 5 6.0 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
CHEMBL435538 168646 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL 560 11 1 5 6.0 CC[C@@H](C)[C@H](C(=O)O)N1C[C@H](CN2CCC(c3cc(Cc4ccccc4)nn3CC)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2003.12.006
3009355 3989 None 18 Mouse Binding pIC50 = 9.0 9.0 - 1
Displacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hrDisplacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hr
ChEMBL 533 6 0 6 4.5 COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F 10.1016/j.ejmech.2018.01.085
807 3989 None 18 Mouse Binding pIC50 = 9.0 9.0 - 1
Displacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hrDisplacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hr
ChEMBL 533 6 0 6 4.5 COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F 10.1016/j.ejmech.2018.01.085
CHEMBL82301 3989 None 18 Mouse Binding pIC50 = 9.0 9.0 - 1
Displacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hrDisplacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hr
ChEMBL 533 6 0 6 4.5 COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F 10.1016/j.ejmech.2018.01.085
DB06652 3989 None 18 Mouse Binding pIC50 = 9.0 9.0 - 1
Displacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hrDisplacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hr
ChEMBL 533 6 0 6 4.5 COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F 10.1016/j.ejmech.2018.01.085
44590635 177004 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 493 10 1 3 5.1 CCN(C(=O)Cc1ccc(F)cc1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 10.1016/j.bmcl.2009.01.009
CHEMBL461690 177004 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 493 10 1 3 5.1 CCN(C(=O)Cc1ccc(F)cc1)C1CCN(C(C)C[C@H](NC(=O)C2CCC2)c2ccccc2)CC1 10.1016/j.bmcl.2009.01.009
76335673 104844 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Antagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 JR-FL-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assayAntagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 JR-FL-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assay
ChEMBL 652 18 1 6 8.8 Cc1nnc(CCCCCCCCCCN=[N+]=[N-])n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1 10.1021/ml400370w
CHEMBL3109175 104844 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Antagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 JR-FL-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assayAntagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 JR-FL-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assay
ChEMBL 652 18 1 6 8.8 Cc1nnc(CCCCCCCCCCN=[N+]=[N-])n1C1CC2CCC(C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1 10.1021/ml400370w
489315 107416 None 0 Human Binding pIC50 = 9 9.0 - 0
Ability to inhibit binding of [125I]-MIP-1 alpha to C-C chemokine receptor type 5 in Chinese hamster ovary (CHO) cell membranesAbility to inhibit binding of [125I]-MIP-1 alpha to C-C chemokine receptor type 5 in Chinese hamster ovary (CHO) cell membranes
ChEMBL 474 9 1 3 6.1 OC1(CCCc2ccccc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(01)00652-7
CHEMBL317710 107416 None 0 Human Binding pIC50 = 9 9.0 - 0
Ability to inhibit binding of [125I]-MIP-1 alpha to C-C chemokine receptor type 5 in Chinese hamster ovary (CHO) cell membranesAbility to inhibit binding of [125I]-MIP-1 alpha to C-C chemokine receptor type 5 in Chinese hamster ovary (CHO) cell membranes
ChEMBL 474 9 1 3 6.1 OC1(CCCc2ccccc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(01)00652-7
23650547 179185 None 0 Human Binding pIC50 = 9 9.0 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 459 6 0 3 4.4 Cc1cccc(C)c1C(=O)N1CCC(N2CC[C@@H](N(Cc3ccccc3)C(=O)C3CC3)C2)CC1 10.1016/j.bmcl.2009.01.012
CHEMBL471623 179185 None 0 Human Binding pIC50 = 9 9.0 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 459 6 0 3 4.4 Cc1cccc(C)c1C(=O)N1CCC(N2CC[C@@H](N(Cc3ccccc3)C(=O)C3CC3)C2)CC1 10.1016/j.bmcl.2009.01.012
44590394 183988 None 0 Human Binding pIC50 = 9 9.0 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 485 6 0 3 5.0 Cc1cccc(C)c1C(=O)N1[C@H]2CC[C@@H]1C[C@@H](N1CC[C@@H](N(Cc3ccccc3)C(=O)C3CC3)C1)C2 10.1016/j.bmcl.2009.01.012
CHEMBL481068 183988 None 0 Human Binding pIC50 = 9 9.0 - 0
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
ChEMBL 485 6 0 3 5.0 Cc1cccc(C)c1C(=O)N1[C@H]2CC[C@@H]1C[C@@H](N1CC[C@@H](N(Cc3ccccc3)C(=O)C3CC3)C1)C2 10.1016/j.bmcl.2009.01.012
59959034 79041 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 505 8 1 6 4.4 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4cnccn34)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2005.02.030
CHEMBL2113088 79041 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 505 8 1 6 4.4 O=C(O)[C@@H](CC1CCC1)N1C[C@H](CN2CCC(c3cnc4cnccn34)CC2)[C@@H](c2cccc(F)c2)C1 10.1016/j.bmcl.2005.02.030
44332814 163766 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 556 11 2 6 5.2 OC1(CCCc2ccc(Cc3nnn[nH]3)cc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00605-4
CHEMBL420465 163766 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
ChEMBL 556 11 2 6 5.2 OC1(CCCc2ccc(Cc3nnn[nH]3)cc2)CCN(C[C@H]2CN(CC3CCCCC3)C[C@@H]2c2ccccc2)CC1 10.1016/s0960-894x(02)00605-4
16073662 139363 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
ChEMBL 630 11 0 6 5.2 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2006.03.089
CHEMBL379082 139363 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
ChEMBL 630 11 0 6 5.2 CCN(C(=O)Cc1ccc(S(C)(=O)=O)cc1)C1CCN(CC[C@H](c2ccc(S(C)(=O)=O)cc2)c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2006.03.089
25132603 103346 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]MIP-1beta from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1beta from human CCR5 expressed in CHO cells
ChEMBL 546 5 0 4 7.2 Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CCC1(c2cccc(Cl)c2)CCN(C(=O)C(C)(C)C)CC1 10.1021/jm800598a
CHEMBL3084499 103346 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]MIP-1beta from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1beta from human CCR5 expressed in CHO cells
ChEMBL 546 5 0 4 7.2 Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CC[C@H](C1)N2CCC1(c2cccc(Cl)c2)CCN(C(=O)C(C)(C)C)CC1 10.1021/jm800598a
44565854 183969 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
ChEMBL 559 11 1 5 6.7 CCc1nc(Cc2ccccc2)sc1C1CCN(C[C@H]2CN([C@H](CC(C)C)C(=O)O)C[C@@H]2c2ccccc2)CC1 10.1016/j.ejmech.2008.01.040
CHEMBL480890 183969<