Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
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Type		 Activity
Relation		 Activity
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1218 3616 None 23 Human Functional pEC50 = 8.9 8.9 295 4
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
ChEMBL 289 1 3 3 3.0 Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1 10.1021/acsmedchemlett.9b00050
938 3616 None 23 Human Functional pEC50 = 8.9 8.9 295 4
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
ChEMBL 289 1 3 3 3.0 Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1 10.1021/acsmedchemlett.9b00050
CHEMBL353335 3616 None 23 Human Functional pEC50 = 8.9 8.9 295 4
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
ChEMBL 289 1 3 3 3.0 Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1 10.1021/acsmedchemlett.9b00050
86764103 132505 None 15 Human Functional pEC50 = 7.9 7.9 -2 2
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
ChEMBL 389 5 1 6 3.1 Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C 10.1021/acsmedchemlett.9b00050
CHEMBL3697578 132505 None 15 Human Functional pEC50 = 7.9 7.9 -2 2
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
ChEMBL 389 5 1 6 3.1 Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C 10.1021/acsmedchemlett.9b00050
11938 2412 None 8 Mouse Functional pEC50 = 5.8 5.8 -69 4
Agonist activity at mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins by HTRF assayAgonist activity at mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins by HTRF assay
ChEMBL 443 4 1 4 4.4 C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl 10.1021/acs.jmedchem.1c01887
146192952 2412 None 8 Mouse Functional pEC50 = 5.8 5.8 -69 4
Agonist activity at mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins by HTRF assayAgonist activity at mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins by HTRF assay
ChEMBL 443 4 1 4 4.4 C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl 10.1021/acs.jmedchem.1c01887
CHEMBL4468760 2412 None 8 Mouse Functional pEC50 = 5.8 5.8 -69 4
Agonist activity at mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins by HTRF assayAgonist activity at mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins by HTRF assay
ChEMBL 443 4 1 4 4.4 C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl 10.1021/acs.jmedchem.1c01887
681 1465 None 47 Human Functional pEC50 = 8.7 8.7 1 15
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/acsmedchemlett.9b00050
681.0 1465 None 47 Human Functional pEC50 = 8.7 8.7 1 15
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/acsmedchemlett.9b00050
940 1465 None 47 Human Functional pEC50 = 8.7 8.7 1 15
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/acsmedchemlett.9b00050
947 1465 None 47 Human Functional pEC50 = 8.7 8.7 1 15
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/acsmedchemlett.9b00050
CHEMBL59 1465 None 47 Human Functional pEC50 = 8.7 8.7 1 15
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/acsmedchemlett.9b00050
DB00988 1465 None 47 Human Functional pEC50 = 8.7 8.7 1 15
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/acsmedchemlett.9b00050
75202022 170913 None 5 Human Functional pEC50 = 8.4 8.4 -1 2
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
ChEMBL 363 3 1 6 3.3 Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C 10.1021/acsmedchemlett.9b00050
CHEMBL4453318 170913 None 5 Human Functional pEC50 = 8.4 8.4 -1 2
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
ChEMBL 363 3 1 6 3.3 Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C 10.1021/acsmedchemlett.9b00050
11681599 75199 None 0 Human Functional pKi = 10.3 10.3 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 301 0 1 2 3.7 CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1 10.1021/jm051237e
CHEMBL203637 75199 None 0 Human Functional pKi = 10.3 10.3 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 301 0 1 2 3.7 CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1 10.1021/jm051237e
11623343 140929 None 0 Human Functional pKi = 9.3 9.3 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 283 0 2 3 2.7 CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1 10.1021/jm051237e
CHEMBL381936 140929 None 0 Human Functional pKi = 9.3 9.3 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 283 0 2 3 2.7 CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1 10.1021/jm051237e
11493746 141410 None 0 Human Functional pKi = 8.9 8.9 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 335 0 1 2 4.3 CN1CCc2ccccc2Cc2cc(Cl)c(O)c(Cl)c2CC1 10.1021/jm051237e
CHEMBL383451 141410 None 0 Human Functional pKi = 8.9 8.9 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 335 0 1 2 4.3 CN1CCc2ccccc2Cc2cc(Cl)c(O)c(Cl)c2CC1 10.1021/jm051237e
11595240 140275 None 0 Human Functional pKi = 8.8 8.8 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 301 0 1 2 3.7 CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1 10.1021/jm051237e
CHEMBL380464 140275 None 0 Human Functional pKi = 8.8 8.8 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 301 0 1 2 3.7 CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1 10.1021/jm051237e
11558055 73177 None 0 Human Functional pKi = 8.8 8.8 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm051237e
CHEMBL1204122 73177 None 0 Human Functional pKi = 8.8 8.8 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm051237e
CHEMBL201170 73177 None 0 Human Functional pKi = 8.8 8.8 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm051237e
11558055 73177 None 0 Human Functional pKi = 8.8 8.8 - 0
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm050846j
CHEMBL1204122 73177 None 0 Human Functional pKi = 8.8 8.8 - 0
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm050846j
CHEMBL201170 73177 None 0 Human Functional pKi = 8.8 8.8 - 0
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm050846j
11522339 75278 None 0 Human Functional pKi = 8.0 8.0 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2c(O)cccc2CC1 10.1021/jm051237e
CHEMBL203689 75278 None 0 Human Functional pKi = 8.0 8.0 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2c(O)cccc2CC1 10.1021/jm051237e
11500677 140935 None 0 Human Functional pKi = 6.0 6.0 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 281 1 0 2 3.3 COc1ccc2c(c1)Cc1ccccc1CCN(C)CC2 10.1021/jm051237e
CHEMBL381946 140935 None 0 Human Functional pKi = 6.0 6.0 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 281 1 0 2 3.3 COc1ccc2c(c1)Cc1ccccc1CCN(C)CC2 10.1021/jm051237e
11573806 75443 None 0 Human Functional pKi = 7.9 7.9 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 311 2 0 3 3.3 COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2 10.1021/jm051237e
CHEMBL204065 75443 None 0 Human Functional pKi = 7.9 7.9 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 311 2 0 3 3.3 COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2 10.1021/jm051237e
5249952 73433 None 5 Human Functional pKi = 7.0 7.0 - 0
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 304 1 1 1 4.4 CN1CCc2c([nH]c3ccccc23)CC(c2ccccc2)CC1 10.1021/jm050846j
CHEMBL201584 73433 None 5 Human Functional pKi = 7.0 7.0 - 0
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 304 1 1 1 4.4 CN1CCc2c([nH]c3ccccc23)CC(c2ccccc2)CC1 10.1021/jm050846j
4350931 169416 None 30 Human Functional pKi = 7.9 7.9 - 1
Activity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay
ChEMBL 290 0 1 1 3.8 CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm060213k
CHEMBL441618 169416 None 30 Human Functional pKi = 7.9 7.9 - 1
Activity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay
ChEMBL 290 0 1 1 3.8 CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm060213k
4350931 169416 None 30 Human Functional pKi = 7.9 7.9 - 1
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 290 0 1 1 3.8 CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm051237e
CHEMBL441618 169416 None 30 Human Functional pKi = 7.9 7.9 - 1
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 290 0 1 1 3.8 CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm051237e
42626289 148167 None 0 Human Functional pKi = 6.9 6.9 - 0
Antagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium responseAntagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium response
ChEMBL 379 7 0 4 3.3 COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1 10.1016/j.bmc.2007.06.002
CHEMBL393492 148167 None 0 Human Functional pKi = 6.9 6.9 - 0
Antagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium responseAntagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium response
ChEMBL 379 7 0 4 3.3 COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1 10.1016/j.bmc.2007.06.002
11566745 74720 None 0 Human Functional pKi = 8.6 8.6 - 0
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 283 0 2 3 2.7 CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1 10.1021/jm050846j
CHEMBL1202298 74720 None 0 Human Functional pKi = 8.6 8.6 - 0
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 283 0 2 3 2.7 CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1 10.1021/jm050846j
CHEMBL203029 74720 None 0 Human Functional pKi = 8.6 8.6 - 0
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 283 0 2 3 2.7 CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1 10.1021/jm050846j
16090814 81612 None 0 Human Functional pKi = 8.6 8.6 - 0
Activity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay
ChEMBL 304 0 1 1 4.2 CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm060213k
CHEMBL216258 81612 None 0 Human Functional pKi = 8.6 8.6 - 0
Activity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay
ChEMBL 304 0 1 1 4.2 CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm060213k
11716449 141302 None 0 Human Functional pKi = 7.7 7.7 - 0
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 304 1 1 1 4.2 CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm050846j
CHEMBL382850 141302 None 0 Human Functional pKi = 7.7 7.7 - 0
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 304 1 1 1 4.2 CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm050846j
5249956 73420 None 0 Human Functional pKi = 8.5 8.5 - 0
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 251 0 0 1 3.3 CN1CCc2ccccc2Cc2ccccc2CC1 10.1021/jm050846j
CHEMBL201525 73420 None 0 Human Functional pKi = 8.5 8.5 - 0
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 251 0 0 1 3.3 CN1CCc2ccccc2Cc2ccccc2CC1 10.1021/jm050846j
11573628 74725 None 0 Human Functional pKi = 8.5 8.5 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 301 0 1 2 3.7 CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1 10.1021/jm051237e
CHEMBL203047 74725 None 0 Human Functional pKi = 8.5 8.5 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 301 0 1 2 3.7 CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1 10.1021/jm051237e
11637457 73112 None 0 Human Functional pKi = 7.5 7.5 - 0
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 257 0 0 2 3.4 CN1CCc2ccccc2Cc2ccsc2CC1 10.1021/jm050846j
CHEMBL201093 73112 None 0 Human Functional pKi = 7.5 7.5 - 0
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 257 0 0 2 3.4 CN1CCc2ccccc2Cc2ccsc2CC1 10.1021/jm050846j
9992499 73411 None 0 Human Functional pKi = 6.5 6.5 - 0
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 254 0 0 2 2.6 CN1CCc2ccccc2Cc2ccn(C)c2CC1 10.1021/jm050846j
CHEMBL201483 73411 None 0 Human Functional pKi = 6.5 6.5 - 0
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 254 0 0 2 2.6 CN1CCc2ccccc2Cc2ccn(C)c2CC1 10.1021/jm050846j
11716438 140969 None 0 Human Functional pKi = 7.4 7.4 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2cc(O)ccc2CC1 10.1021/jm051237e
CHEMBL382010 140969 None 0 Human Functional pKi = 7.4 7.4 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2cc(O)ccc2CC1 10.1021/jm051237e
44436300 148924 None 0 Human Functional pKi = 6.4 6.4 - 0
Antagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium responseAntagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium response
ChEMBL 399 6 0 5 2.4 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2007.06.002
CHEMBL394110 148924 None 0 Human Functional pKi = 6.4 6.4 - 0
Antagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium responseAntagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium response
ChEMBL 399 6 0 5 2.4 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2007.06.002
11558247 75449 None 0 Human Functional pKi = 7.4 7.4 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 282 0 2 3 2.6 CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1 10.1021/jm051237e
CHEMBL204098 75449 None 0 Human Functional pKi = 7.4 7.4 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 282 0 2 3 2.6 CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1 10.1021/jm051237e
75201901 166520 None 21 Human Functional pKi = 8.3 8.3 - 4
Agonist activity at dopamine D5 receptor (unknown origin)Agonist activity at dopamine D5 receptor (unknown origin)
ChEMBL 356 3 0 6 4.9 Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12 10.1021/acs.jmedchem.8b01622
CHEMBL4277264 166520 None 21 Human Functional pKi = 8.3 8.3 - 4
Agonist activity at dopamine D5 receptor (unknown origin)Agonist activity at dopamine D5 receptor (unknown origin)
ChEMBL 356 3 0 6 4.9 Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12 10.1021/acs.jmedchem.8b01622
11536995 139642 None 0 Human Functional pKi = 7.3 7.3 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 281 1 0 2 3.3 COc1cccc2c1Cc1ccccc1CCN(C)CC2 10.1021/jm051237e
CHEMBL379662 139642 None 0 Human Functional pKi = 7.3 7.3 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 281 1 0 2 3.3 COc1cccc2c1Cc1ccccc1CCN(C)CC2 10.1021/jm051237e
11718008 75317 None 0 Human Functional pKi = 7.2 7.2 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 349 1 0 2 4.6 COc1c(Cl)cc2c(c1Cl)Cc1ccccc1CCN(C)CC2 10.1021/jm051237e
CHEMBL203734 75317 None 0 Human Functional pKi = 7.2 7.2 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 349 1 0 2 4.6 COc1c(Cl)cc2c(c1Cl)Cc1ccccc1CCN(C)CC2 10.1021/jm051237e
44408818 140252 None 0 Human Functional pKi = 8.1 8.1 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 281 1 0 2 3.3 COc1ccc2c(c1)CCN(C)CCc1ccccc1C2 10.1021/jm051237e
CHEMBL380330 140252 None 0 Human Functional pKi = 8.1 8.1 - 0
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 281 1 0 2 3.3 COc1ccc2c(c1)CCN(C)CCc1ccccc1C2 10.1021/jm051237e
16090821 81864 None 0 Human Functional pKi = 7.1 7.1 - 0
Activity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay
ChEMBL 304 0 1 1 4.2 CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1 10.1021/jm060213k
CHEMBL216439 81864 None 0 Human Functional pKi = 7.1 7.1 - 0
Activity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay
ChEMBL 304 0 1 1 4.2 CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1 10.1021/jm060213k
122324 205 None 17 Human Functional pEC50 = 6.6 6.6 -128 4
UnclassifiedUnclassified
Guide to Pharmacology 271 2 3 4 2.4 NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1 16318870
6077 205 None 17 Human Functional pEC50 = 6.6 6.6 -128 4
UnclassifiedUnclassified
Guide to Pharmacology 271 2 3 4 2.4 NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1 16318870
CHEMBL86931 205 None 17 Human Functional pEC50 = 6.6 6.6 -128 4
UnclassifiedUnclassified
Guide to Pharmacology 271 2 3 4 2.4 NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1 16318870


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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
Sel. page Common
name		 GPCRdb
ID		 Reference
ligand		 Vendors

 Species

 Assay
Type		 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
3158 56283 None 21 Human Binding pAC50 = 5.8 5.8 - 20
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 279 3 0 2 4.0 CN(C)CCC=C1c2ccccc2COc2ccccc21 10.1038/s41467-023-40064-9
3158.0 56283 None 21 Human Binding pAC50 = 5.8 5.8 - 20
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 279 3 0 2 4.0 CN(C)CCC=C1c2ccccc2COc2ccccc21 10.1038/s41467-023-40064-9
CHEMBL1628227 56283 None 21 Human Binding pAC50 = 5.8 5.8 - 20
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 279 3 0 2 4.0 CN(C)CCC=C1c2ccccc2COc2ccccc21 10.1038/s41467-023-40064-9
DB01142 56283 None 21 Human Binding pAC50 = 5.8 5.8 - 20
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 279 3 0 2 4.0 CN(C)CCC=C1c2ccccc2COc2ccccc21 10.1038/s41467-023-40064-9
1353 1911 None 63 Human Binding pAC50 = 6.7 6.7 -54 85
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
3559 1911 None 63 Human Binding pAC50 = 6.7 6.7 -54 85
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
3559.0 1911 None 63 Human Binding pAC50 = 6.7 6.7 -54 85
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
86 1911 None 63 Human Binding pAC50 = 6.7 6.7 -54 85
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
CHEMBL54 1911 None 63 Human Binding pAC50 = 6.7 6.7 -54 85
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
DB00502 1911 None 63 Human Binding pAC50 = 6.7 6.7 -54 85
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
1613 2348 None 42 Human Binding pAC50 = 6.6 6.6 -5 44
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
205 2348 None 42 Human Binding pAC50 = 6.6 6.6 -5 44
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
3964 2348 None 42 Human Binding pAC50 = 6.6 6.6 -5 44
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
3964.0 2348 None 42 Human Binding pAC50 = 6.6 6.6 -5 44
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
CHEMBL831 2348 None 42 Human Binding pAC50 = 6.6 6.6 -5 44
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
DB00408 2348 None 42 Human Binding pAC50 = 6.6 6.6 -5 44
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
135398745 2914 None 65 Human Binding pAC50 = 6.4 6.4 -26 65
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1038/s41467-023-40064-9
135398745.0 2914 None 65 Human Binding pAC50 = 6.4 6.4 -26 65
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1038/s41467-023-40064-9
47 2914 None 65 Human Binding pAC50 = 6.4 6.4 -26 65
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1038/s41467-023-40064-9
CHEMBL715 2914 None 65 Human Binding pAC50 = 6.4 6.4 -26 65
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1038/s41467-023-40064-9
DB00334 2914 None 65 Human Binding pAC50 = 6.4 6.4 -26 65
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1038/s41467-023-40064-9
191 403 None 60 Human Binding pAC50 = 6.3 6.3 - 28
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
201 403 None 60 Human Binding pAC50 = 6.3 6.3 - 28
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
2170 403 None 60 Human Binding pAC50 = 6.3 6.3 - 28
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
2170.0 403 None 60 Human Binding pAC50 = 6.3 6.3 - 28
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
CHEMBL1113 403 None 60 Human Binding pAC50 = 6.3 6.3 - 28
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
DB00543 403 None 60 Human Binding pAC50 = 6.3 6.3 - 28
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
2284 3182 None 26 Human Binding pAC50 = 5.2 5.2 - 28
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C 10.1038/s41467-023-40064-9
4926 3182 None 26 Human Binding pAC50 = 5.2 5.2 - 28
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C 10.1038/s41467-023-40064-9
7281 3182 None 26 Human Binding pAC50 = 5.2 5.2 - 28
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C 10.1038/s41467-023-40064-9
CHEMBL564 3182 None 26 Human Binding pAC50 = 5.2 5.2 - 28
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C 10.1038/s41467-023-40064-9
DB00420 3182 None 26 Human Binding pAC50 = 5.2 5.2 - 28
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C 10.1038/s41467-023-40064-9
1427 2013 None 42 Human Binding pAC50 = 5.1 5.1 - 26
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
357 2013 None 42 Human Binding pAC50 = 5.1 5.1 - 26
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
3696 2013 None 42 Human Binding pAC50 = 5.1 5.1 - 26
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
CHEMBL11 2013 None 42 Human Binding pAC50 = 5.1 5.1 - 26
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
DB00458 2013 None 42 Human Binding pAC50 = 5.1 5.1 - 26
Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
85090335 181220 None 0 Human Binding pEC50 = 7.0 7.0 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 359 3 0 5 3.4 CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccccc1 10.1016/j.bmcl.2020.127696
CHEMBL4760355 181220 None 0 Human Binding pEC50 = 7.0 7.0 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 359 3 0 5 3.4 CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccccc1 10.1016/j.bmcl.2020.127696
168295528 193140 None 0 Human Binding pEC50 = 5.0 5.0 -4 20
Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis
ChEMBL 333 6 4 5 0.9 N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 10.1021/acs.jmedchem.1c00692
CHEMBL5206565 193140 None 0 Human Binding pEC50 = 5.0 5.0 -4 20
Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis
ChEMBL 333 6 4 5 0.9 N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 10.1021/acs.jmedchem.1c00692
CHEMBL5222872 193140 None 0 Human Binding pEC50 = 5.0 5.0 -4 20
Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis
ChEMBL 333 6 4 5 0.9 N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 10.1021/acs.jmedchem.1c00692
85090318 179551 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 413 3 0 5 4.7 Cc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
CHEMBL4740497 179551 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 413 3 0 5 4.7 Cc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
168290235 193077 None 0 Human Binding pEC50 = 4.6 4.6 -16 20
Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis
ChEMBL 315 6 4 3 1.1 C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 10.1021/acs.jmedchem.1c00692
CHEMBL5201074 193077 None 0 Human Binding pEC50 = 4.6 4.6 -16 20
Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis
ChEMBL 315 6 4 3 1.1 C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 10.1021/acs.jmedchem.1c00692
CHEMBL5222491 193077 None 0 Human Binding pEC50 = 4.6 4.6 -16 20
Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis
ChEMBL 315 6 4 3 1.1 C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 10.1021/acs.jmedchem.1c00692
85090319 180716 None 0 Human Binding pEC50 = 7.6 7.6 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 401 3 0 6 3.9 COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
CHEMBL4754602 180716 None 0 Human Binding pEC50 = 7.6 7.6 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 401 3 0 6 3.9 COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
85090328 181141 None 0 Human Binding pEC50 = 7.6 7.6 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 385 2 0 5 4.2 Cc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
CHEMBL4759339 181141 None 0 Human Binding pEC50 = 7.6 7.6 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 385 2 0 5 4.2 Cc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
85090333 181407 None 0 Human Binding pEC50 = 7.6 7.6 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 399 2 0 5 4.6 Cc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
CHEMBL4762375 181407 None 0 Human Binding pEC50 = 7.6 7.6 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 399 2 0 5 4.6 Cc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
85090332 180825 None 0 Human Binding pEC50 = 7.6 7.6 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 435 3 0 6 4.6 COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl 10.1016/j.bmcl.2020.127696
CHEMBL4755709 180825 None 0 Human Binding pEC50 = 7.6 7.6 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 435 3 0 6 4.6 COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl 10.1016/j.bmcl.2020.127696
2030130 20986 None 17 Human Binding pEC50 = 7.5 7.5 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 385 2 0 5 4.3 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCCC3)nc21 10.1016/j.bmcl.2020.127696
CHEMBL1311333 20986 None 17 Human Binding pEC50 = 7.5 7.5 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 385 2 0 5 4.3 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCCC3)nc21 10.1016/j.bmcl.2020.127696
85090338 180867 None 0 Human Binding pEC50 = 7.5 7.5 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 389 4 0 6 3.4 COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
CHEMBL4756163 180867 None 0 Human Binding pEC50 = 7.5 7.5 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 389 4 0 6 3.4 COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
168294767 193128 None 0 Human Binding pEC50 = 4.5 4.5 -4 20
Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis
ChEMBL 313 8 4 5 0.9 CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 10.1021/acs.jmedchem.1c00692
CHEMBL5207281 193128 None 0 Human Binding pEC50 = 4.5 4.5 -4 20
Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis
ChEMBL 313 8 4 5 0.9 CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 10.1021/acs.jmedchem.1c00692
CHEMBL5222802 193128 None 0 Human Binding pEC50 = 4.5 4.5 -4 20
Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis
ChEMBL 313 8 4 5 0.9 CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 10.1021/acs.jmedchem.1c00692
164612037 185483 None 0 Human Binding pEC50 = 5.4 5.4 -4 20
Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis
ChEMBL 326 8 4 4 1.8 CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C 10.1021/acs.jmedchem.1c00692
CHEMBL4860528 185483 None 0 Human Binding pEC50 = 5.4 5.4 -4 20
Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis
ChEMBL 326 8 4 4 1.8 CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C 10.1021/acs.jmedchem.1c00692
85090324 180798 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 405 2 0 5 4.5 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCC3)nc21 10.1016/j.bmcl.2020.127696
CHEMBL4755481 180798 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 405 2 0 5 4.5 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCC3)nc21 10.1016/j.bmcl.2020.127696
85090325 179855 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 405 2 0 5 4.5 Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCC3)nc21 10.1016/j.bmcl.2020.127696
CHEMBL4744261 179855 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 405 2 0 5 4.5 Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCC3)nc21 10.1016/j.bmcl.2020.127696
85090321 182919 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 373 3 0 5 3.7 Cc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
CHEMBL4790909 182919 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 373 3 0 5 3.7 Cc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
85090329 182788 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 419 2 0 5 4.9 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCCC3)nc21 10.1016/j.bmcl.2020.127696
CHEMBL4789255 182788 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 419 2 0 5 4.9 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCCC3)nc21 10.1016/j.bmcl.2020.127696
11938 2412 None 8 Mouse Binding pEC50 = 6.3 6.3 - 0
Positive allosteric modulation of mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay
ChEMBL 443 4 1 4 4.4 C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl 10.1021/acs.jmedchem.1c01887
146192952 2412 None 8 Mouse Binding pEC50 = 6.3 6.3 - 0
Positive allosteric modulation of mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay
ChEMBL 443 4 1 4 4.4 C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl 10.1021/acs.jmedchem.1c01887
CHEMBL4468760 2412 None 8 Mouse Binding pEC50 = 6.3 6.3 - 0
Positive allosteric modulation of mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay
ChEMBL 443 4 1 4 4.4 C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl 10.1021/acs.jmedchem.1c01887
85090334 180731 None 0 Human Binding pEC50 = 7.3 7.3 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 399 3 0 5 4.4 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(CC3CCCCC3)nc21 10.1016/j.bmcl.2020.127696
CHEMBL4754761 180731 None 0 Human Binding pEC50 = 7.3 7.3 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 399 3 0 5 4.4 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(CC3CCCCC3)nc21 10.1016/j.bmcl.2020.127696
85090323 182028 None 0 Human Binding pEC50 = 7.3 7.3 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 393 3 0 5 4.1 CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccc(Cl)cc1 10.1016/j.bmcl.2020.127696
CHEMBL4779641 182028 None 0 Human Binding pEC50 = 7.3 7.3 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 393 3 0 5 4.1 CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccc(Cl)cc1 10.1016/j.bmcl.2020.127696
85090326 182879 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 423 4 0 6 4.1 COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl 10.1016/j.bmcl.2020.127696
CHEMBL4790277 182879 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 423 4 0 6 4.1 COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl 10.1016/j.bmcl.2020.127696
85090331 181559 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 449 3 0 6 4.9 COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl 10.1016/j.bmcl.2020.127696
CHEMBL4764398 181559 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 449 3 0 6 4.9 COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl 10.1016/j.bmcl.2020.127696
85090322 179565 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 415 3 0 6 4.3 COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
CHEMBL4740678 179565 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 415 3 0 6 4.3 COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
85090339 182411 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 393 3 0 5 4.1 CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1cccc(Cl)c1 10.1016/j.bmcl.2020.127696
CHEMBL4784143 182411 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 393 3 0 5 4.1 CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1cccc(Cl)c1 10.1016/j.bmcl.2020.127696
85090320 182669 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 433 3 0 5 5.0 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(CC3CCCCC3)nc21 10.1016/j.bmcl.2020.127696
CHEMBL4787728 182669 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 433 3 0 5 5.0 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(CC3CCCCC3)nc21 10.1016/j.bmcl.2020.127696
4901726 180905 None 6 Human Binding pEC50 = 7.1 7.1 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 419 2 0 5 4.9 Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCCC3)nc21 10.1016/j.bmcl.2020.127696
CHEMBL4756486 180905 None 6 Human Binding pEC50 = 7.1 7.1 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 419 2 0 5 4.9 Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCCC3)nc21 10.1016/j.bmcl.2020.127696
76284418 182424 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 371 2 0 5 3.9 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCC3)nc21 10.1016/j.bmcl.2020.127696
CHEMBL4784295 182424 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 371 2 0 5 3.9 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCC3)nc21 10.1016/j.bmcl.2020.127696
136326241 179534 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 295 1 1 4 2.4 Cn1c2ccccc2c(=O)c2c(=O)[nH]c(C3CCCC3)nc21 10.1016/j.bmcl.2020.127696
CHEMBL4740312 179534 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 295 1 1 4 2.4 Cn1c2ccccc2c(=O)c2c(=O)[nH]c(C3CCCC3)nc21 10.1016/j.bmcl.2020.127696
85090330 181179 None 0 Human Binding pEC50 = 7.0 7.0 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 463 4 0 6 5.0 COc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl 10.1016/j.bmcl.2020.127696
CHEMBL4759814 181179 None 0 Human Binding pEC50 = 7.0 7.0 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 463 4 0 6 5.0 COc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl 10.1016/j.bmcl.2020.127696
85090337 183387 None 0 Human Binding pEC50 = 7.0 7.0 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 433 3 0 5 5.0 Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(CC3CCCCC3)nc21 10.1016/j.bmcl.2020.127696
CHEMBL4796761 183387 None 0 Human Binding pEC50 = 7.0 7.0 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 433 3 0 5 5.0 Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(CC3CCCCC3)nc21 10.1016/j.bmcl.2020.127696
76284419 183354 None 0 Human Binding pEC50 = 7.0 7.0 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 343 2 0 5 3.1 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CC3)nc21 10.1016/j.bmcl.2020.127696
CHEMBL4796389 183354 None 0 Human Binding pEC50 = 7.0 7.0 - 0
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 343 2 0 5 3.1 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CC3)nc21 10.1016/j.bmcl.2020.127696
3036864 205211 None 16 Human Binding pIC50 = 9.8 9.8 -3 27
Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.bmc.2013.03.016
CHEMBL1256645 205211 None 16 Human Binding pIC50 = 9.8 9.8 -3 27
Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.bmc.2013.03.016
CHEMBL1814790 205211 None 16 Human Binding pIC50 = 9.8 9.8 -3 27
Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.bmc.2013.03.016
CHEMBL62 205211 None 16 Human Binding pIC50 = 9.8 9.8 -3 27
Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.bmc.2013.03.016
3036864 205211 None 16 Human Binding pIC50 = 9.4 9.4 -3 27
Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2013.01.044
CHEMBL1256645 205211 None 16 Human Binding pIC50 = 9.4 9.4 -3 27
Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2013.01.044
CHEMBL1814790 205211 None 16 Human Binding pIC50 = 9.4 9.4 -3 27
Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2013.01.044
CHEMBL62 205211 None 16 Human Binding pIC50 = 9.4 9.4 -3 27
Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2013.01.044
5018 3549 None 8 Human Binding pIC50 = 9.3 9.3 -2 9
Displacement of [3H]SCH 23390 from human recombinant D5 receptor expressed in GH4 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]SCH 23390 from human recombinant D5 receptor expressed in GH4 cells measured after 60 mins by scintillation counting method
ChEMBL 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O 10.1016/j.bmc.2016.11.014
943 3549 None 8 Human Binding pIC50 = 9.3 9.3 -2 9
Displacement of [3H]SCH 23390 from human recombinant D5 receptor expressed in GH4 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]SCH 23390 from human recombinant D5 receptor expressed in GH4 cells measured after 60 mins by scintillation counting method
ChEMBL 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O 10.1016/j.bmc.2016.11.014
946 3549 None 8 Human Binding pIC50 = 9.3 9.3 -2 9
Displacement of [3H]SCH 23390 from human recombinant D5 receptor expressed in GH4 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]SCH 23390 from human recombinant D5 receptor expressed in GH4 cells measured after 60 mins by scintillation counting method
ChEMBL 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O 10.1016/j.bmc.2016.11.014
CHEMBL13668 3549 None 8 Human Binding pIC50 = 9.3 9.3 -2 9
Displacement of [3H]SCH 23390 from human recombinant D5 receptor expressed in GH4 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]SCH 23390 from human recombinant D5 receptor expressed in GH4 cells measured after 60 mins by scintillation counting method
ChEMBL 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O 10.1016/j.bmc.2016.11.014
5018 3549 None 8 Human Binding pIC50 = 9.3 9.3 -2 9
Displacement of [3H]SCH23390 from human recombinant Dopamine D5 receptor expressed in GH4 cellsDisplacement of [3H]SCH23390 from human recombinant Dopamine D5 receptor expressed in GH4 cells
ChEMBL 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O 10.1016/j.bmc.2016.03.006
943 3549 None 8 Human Binding pIC50 = 9.3 9.3 -2 9
Displacement of [3H]SCH23390 from human recombinant Dopamine D5 receptor expressed in GH4 cellsDisplacement of [3H]SCH23390 from human recombinant Dopamine D5 receptor expressed in GH4 cells
ChEMBL 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O 10.1016/j.bmc.2016.03.006
946 3549 None 8 Human Binding pIC50 = 9.3 9.3 -2 9
Displacement of [3H]SCH23390 from human recombinant Dopamine D5 receptor expressed in GH4 cellsDisplacement of [3H]SCH23390 from human recombinant Dopamine D5 receptor expressed in GH4 cells
ChEMBL 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O 10.1016/j.bmc.2016.03.006
CHEMBL13668 3549 None 8 Human Binding pIC50 = 9.3 9.3 -2 9
Displacement of [3H]SCH23390 from human recombinant Dopamine D5 receptor expressed in GH4 cellsDisplacement of [3H]SCH23390 from human recombinant Dopamine D5 receptor expressed in GH4 cells
ChEMBL 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O 10.1016/j.bmc.2016.03.006
3036864 205211 None 16 Human Binding pIC50 = 9.0 9.0 -3 27
Displacement of radiolabeled SCH-23390 from human dopamine D5 receptorDisplacement of radiolabeled SCH-23390 from human dopamine D5 receptor
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1021/jm8007618
CHEMBL1256645 205211 None 16 Human Binding pIC50 = 9.0 9.0 -3 27
Displacement of radiolabeled SCH-23390 from human dopamine D5 receptorDisplacement of radiolabeled SCH-23390 from human dopamine D5 receptor
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1021/jm8007618
CHEMBL1814790 205211 None 16 Human Binding pIC50 = 9.0 9.0 -3 27
Displacement of radiolabeled SCH-23390 from human dopamine D5 receptorDisplacement of radiolabeled SCH-23390 from human dopamine D5 receptor
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1021/jm8007618
CHEMBL62 205211 None 16 Human Binding pIC50 = 9.0 9.0 -3 27
Displacement of radiolabeled SCH-23390 from human dopamine D5 receptorDisplacement of radiolabeled SCH-23390 from human dopamine D5 receptor
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1021/jm8007618
10907460 9830 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 521 11 1 3 5.8 CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
CHEMBL113956 9830 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 521 11 1 3 5.8 CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
11071079 110656 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 496 9 0 3 6.0 O=C(OCCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/jm010878g
CHEMBL325516 110656 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 496 9 0 3 6.0 O=C(OCCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/jm010878g
11730467 11032 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 476 10 0 2 6.0 O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/jm010878g
CHEMBL117537 11032 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 476 10 0 2 6.0 O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/jm010878g
11113605 10510 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 480 9 0 2 5.8 O=C(CCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/jm010878g
CHEMBL116735 10510 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 480 9 0 2 5.8 O=C(CCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/jm010878g
10918307 9987 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 514 5 1 7 2.6 CNC(=O)CN1CN(c2ccccc2)C2(CCN(C(=O)OCc3cc4c(cc3Cl)OCO4)CC2)C1=O 10.1021/jm010878g
CHEMBL114825 9987 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 514 5 1 7 2.6 CNC(=O)CN1CN(c2ccccc2)C2(CCN(C(=O)OCc3cc4c(cc3Cl)OCO4)CC2)C1=O 10.1021/jm010878g
11059058 10093 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 429 3 1 7 4.1 O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1 10.1021/jm010878g
CHEMBL115444 10093 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 429 3 1 7 4.1 O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1 10.1021/jm010878g
11005810 10469 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 517 10 1 4 6.2 N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
CHEMBL116463 10469 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 517 10 1 4 6.2 N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
10885636 111079 None 0 Human Binding pIC50 = 6 6.0 - 0
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 503 9 0 4 5.7 N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
CHEMBL326263 111079 None 0 Human Binding pIC50 = 6 6.0 - 0
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 503 9 0 4 5.7 N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
164612037 185483 None 0 Human Binding pKd = 9.6 9.6 -4 20
Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis
ChEMBL 326 8 4 4 1.8 CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C 10.1021/acs.jmedchem.1c00692
CHEMBL4860528 185483 None 0 Human Binding pKd = 9.6 9.6 -4 20
Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis
ChEMBL 326 8 4 4 1.8 CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C 10.1021/acs.jmedchem.1c00692
168290235 193077 None 0 Human Binding pKd = 9.6 9.6 -16 20
Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis
ChEMBL 315 6 4 3 1.1 C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 10.1021/acs.jmedchem.1c00692
CHEMBL5201074 193077 None 0 Human Binding pKd = 9.6 9.6 -16 20
Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis
ChEMBL 315 6 4 3 1.1 C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 10.1021/acs.jmedchem.1c00692
CHEMBL5222491 193077 None 0 Human Binding pKd = 9.6 9.6 -16 20
Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis
ChEMBL 315 6 4 3 1.1 C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 10.1021/acs.jmedchem.1c00692
168294767 193128 None 0 Human Binding pKd = 9.6 9.6 -4 20
Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis
ChEMBL 313 8 4 5 0.9 CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 10.1021/acs.jmedchem.1c00692
CHEMBL5207281 193128 None 0 Human Binding pKd = 9.6 9.6 -4 20
Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis
ChEMBL 313 8 4 5 0.9 CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 10.1021/acs.jmedchem.1c00692
CHEMBL5222802 193128 None 0 Human Binding pKd = 9.6 9.6 -4 20
Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis
ChEMBL 313 8 4 5 0.9 CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 10.1021/acs.jmedchem.1c00692
168295528 193140 None 0 Human Binding pKd = 9.6 9.6 -4 20
Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis
ChEMBL 333 6 4 5 0.9 N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 10.1021/acs.jmedchem.1c00692
CHEMBL5206565 193140 None 0 Human Binding pKd = 9.6 9.6 -4 20
Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis
ChEMBL 333 6 4 5 0.9 N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 10.1021/acs.jmedchem.1c00692
CHEMBL5222872 193140 None 0 Human Binding pKd = 9.6 9.6 -4 20
Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis
ChEMBL 333 6 4 5 0.9 N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 10.1021/acs.jmedchem.1c00692
11681599 75199 None 0 Human Binding pKi = 10.2 10.2 12 6
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 301 0 1 2 3.7 CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1 10.1021/jm051237e
CHEMBL203637 75199 None 0 Human Binding pKi = 10.2 10.2 12 6
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 301 0 1 2 3.7 CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1 10.1021/jm051237e
3036864 205211 None 16 Human Binding pKi = 9.8 9.8 -3 27
Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2013.01.044
CHEMBL1256645 205211 None 16 Human Binding pKi = 9.8 9.8 -3 27
Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2013.01.044
CHEMBL1814790 205211 None 16 Human Binding pKi = 9.8 9.8 -3 27
Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2013.01.044
CHEMBL62 205211 None 16 Human Binding pKi = 9.8 9.8 -3 27
Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2013.01.044
16665071 93454 None 0 Human Binding pKi = 9.6 9.6 7 4
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 334 1 0 3 3.8 COc1ccc2c(c1)c1c(n2C)Cc2ccccc2CCN(C)CC1 10.1016/j.bmcl.2006.11.093
CHEMBL245764 93454 None 0 Human Binding pKi = 9.6 9.6 7 4
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 334 1 0 3 3.8 COc1ccc2c(c1)c1c(n2C)Cc2ccccc2CCN(C)CC1 10.1016/j.bmcl.2006.11.093
3036864 205211 None 16 Human Binding pKi = 9.5 9.5 -3 27
Antagonist activity at dopamine D5 receptor (unknown origin)Antagonist activity at dopamine D5 receptor (unknown origin)
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2020.127305
CHEMBL1256645 205211 None 16 Human Binding pKi = 9.5 9.5 -3 27
Antagonist activity at dopamine D5 receptor (unknown origin)Antagonist activity at dopamine D5 receptor (unknown origin)
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2020.127305
CHEMBL1814790 205211 None 16 Human Binding pKi = 9.5 9.5 -3 27
Antagonist activity at dopamine D5 receptor (unknown origin)Antagonist activity at dopamine D5 receptor (unknown origin)
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2020.127305
CHEMBL62 205211 None 16 Human Binding pKi = 9.5 9.5 -3 27
Antagonist activity at dopamine D5 receptor (unknown origin)Antagonist activity at dopamine D5 receptor (unknown origin)
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2020.127305
11465618 102453 None 23 Human Binding pKi = 9.4 9.4 -1 19
Displacement of [3H]SCH 23390 from recombinant human D5 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D5 receptor measured after 60 mins by scintillation counting analysis
ChEMBL 354 2 0 2 4.9 CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C 10.1016/j.bmcl.2022.128879
CHEMBL3039528 102453 None 23 Human Binding pKi = 9.4 9.4 -1 19
Displacement of [3H]SCH 23390 from recombinant human D5 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D5 receptor measured after 60 mins by scintillation counting analysis
ChEMBL 354 2 0 2 4.9 CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C 10.1016/j.bmcl.2022.128879
CHEMBL5191141 102453 None 23 Human Binding pKi = 9.4 9.4 -1 19
Displacement of [3H]SCH 23390 from recombinant human D5 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D5 receptor measured after 60 mins by scintillation counting analysis
ChEMBL 354 2 0 2 4.9 CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C 10.1016/j.bmcl.2022.128879
44439943 93419 None 0 Human Binding pKi = 9.4 9.4 1 4
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 306 0 2 2 3.5 CN1CCc2ccccc2Cc2[nH]c3ccc(O)cc3c2CC1 10.1016/j.bmcl.2006.11.093
CHEMBL245570 93419 None 0 Human Binding pKi = 9.4 9.4 1 4
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 306 0 2 2 3.5 CN1CCc2ccccc2Cc2[nH]c3ccc(O)cc3c2CC1 10.1016/j.bmcl.2006.11.093
3036864 205211 None 16 Human Binding pKi = 9.3 9.3 -3 27
Displacement of radiolabeled SCH-23390 from human dopamine D5 receptorDisplacement of radiolabeled SCH-23390 from human dopamine D5 receptor
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1021/jm8007618
CHEMBL1256645 205211 None 16 Human Binding pKi = 9.3 9.3 -3 27
Displacement of radiolabeled SCH-23390 from human dopamine D5 receptorDisplacement of radiolabeled SCH-23390 from human dopamine D5 receptor
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1021/jm8007618
CHEMBL1814790 205211 None 16 Human Binding pKi = 9.3 9.3 -3 27
Displacement of radiolabeled SCH-23390 from human dopamine D5 receptorDisplacement of radiolabeled SCH-23390 from human dopamine D5 receptor
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1021/jm8007618
CHEMBL62 205211 None 16 Human Binding pKi = 9.3 9.3 -3 27
Displacement of radiolabeled SCH-23390 from human dopamine D5 receptorDisplacement of radiolabeled SCH-23390 from human dopamine D5 receptor
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1021/jm8007618
6852376 91633 None 9 Human Binding pKi = 9.3 9.3 3 5
Agonist activity at dopamine D5 receptor (unknown origin)Agonist activity at dopamine D5 receptor (unknown origin)
ChEMBL 255 1 3 3 2.4 Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 10.1016/j.bmcl.2020.127305
CHEMBL1467585 91633 None 9 Human Binding pKi = 9.3 9.3 3 5
Agonist activity at dopamine D5 receptor (unknown origin)Agonist activity at dopamine D5 receptor (unknown origin)
ChEMBL 255 1 3 3 2.4 Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 10.1016/j.bmcl.2020.127305
CHEMBL24077 91633 None 9 Human Binding pKi = 9.3 9.3 3 5
Agonist activity at dopamine D5 receptor (unknown origin)Agonist activity at dopamine D5 receptor (unknown origin)
ChEMBL 255 1 3 3 2.4 Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 10.1016/j.bmcl.2020.127305
CHEMBL503958 91633 None 9 Human Binding pKi = 9.3 9.3 3 5
Agonist activity at dopamine D5 receptor (unknown origin)Agonist activity at dopamine D5 receptor (unknown origin)
ChEMBL 255 1 3 3 2.4 Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 10.1016/j.bmcl.2020.127305
11778580 66148 None 0 Human Binding pKi = 9.2 9.2 5 5
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 283 0 1 3 2.9 CN1CCOc2cc(O)ccc2Cc2ccccc2CC1 10.1021/jm049720x
CHEMBL184050 66148 None 0 Human Binding pKi = 9.2 9.2 5 5
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 283 0 1 3 2.9 CN1CCOc2cc(O)ccc2Cc2ccccc2CC1 10.1021/jm049720x
16090814 81612 None 0 Human Binding pKi = 9.2 9.2 1 5
Displacement of [3H]SCH 23390 from human D5 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D5 dopamine receptor expressed in HEK293 cells
ChEMBL 304 0 1 1 4.2 CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm060213k
CHEMBL216258 81612 None 0 Human Binding pKi = 9.2 9.2 1 5
Displacement of [3H]SCH 23390 from human D5 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D5 dopamine receptor expressed in HEK293 cells
ChEMBL 304 0 1 1 4.2 CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm060213k
11393666 193095 None 0 Human Binding pKi = 9.2 9.2 -1 19
Displacement of [3H]SCH 23390 from recombinant human D5 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D5 receptor measured after 60 mins by scintillation counting analysis
ChEMBL 340 2 1 2 4.6 CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 10.1016/j.bmcl.2022.128879
CHEMBL5201983 193095 None 0 Human Binding pKi = 9.2 9.2 -1 19
Displacement of [3H]SCH 23390 from recombinant human D5 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D5 receptor measured after 60 mins by scintillation counting analysis
ChEMBL 340 2 1 2 4.6 CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 10.1016/j.bmcl.2022.128879
CHEMBL5222597 193095 None 0 Human Binding pKi = 9.2 9.2 -1 19
Displacement of [3H]SCH 23390 from recombinant human D5 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D5 receptor measured after 60 mins by scintillation counting analysis
ChEMBL 340 2 1 2 4.6 CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 10.1016/j.bmcl.2022.128879
11595240 140275 None 0 Human Binding pKi = 9.0 9.0 -3 4
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 301 0 1 2 3.7 CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1 10.1021/jm051237e
CHEMBL380464 140275 None 0 Human Binding pKi = 9.0 9.0 -3 4
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 301 0 1 2 3.7 CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1 10.1021/jm051237e
11488247 203095 None 0 Human Binding pKi = 8.9 8.9 -1 4
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 470 5 1 4 4.5 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C)S(=O)(=O)c3ccccc3)cc2)C1 10.1016/j.bmcl.2009.12.100
CHEMBL599487 203095 None 0 Human Binding pKi = 8.9 8.9 -1 4
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 470 5 1 4 4.5 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C)S(=O)(=O)c3ccccc3)cc2)C1 10.1016/j.bmcl.2009.12.100
46231784 203795 None 0 Human Binding pKi = 8.9 8.9 -2 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 329 0 2 3 3.7 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(O)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
CHEMBL604314 203795 None 0 Human Binding pKi = 8.9 8.9 -2 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 329 0 2 3 3.7 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(O)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
11558055 73177 None 0 Human Binding pKi = 8.8 8.8 -2 6
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm051237e
CHEMBL1204122 73177 None 0 Human Binding pKi = 8.8 8.8 -2 6
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm051237e
CHEMBL201170 73177 None 0 Human Binding pKi = 8.8 8.8 -2 6
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm051237e
11558055 73177 None 0 Human Binding pKi = 8.8 8.8 -2 6
Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1039/C5MD00258C
CHEMBL1204122 73177 None 0 Human Binding pKi = 8.8 8.8 -2 6
Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1039/C5MD00258C
CHEMBL201170 73177 None 0 Human Binding pKi = 8.8 8.8 -2 6
Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1039/C5MD00258C
11558055 73177 None 0 Human Binding pKi = 8.8 8.8 -2 6
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1016/j.bmcl.2006.11.093
CHEMBL1204122 73177 None 0 Human Binding pKi = 8.8 8.8 -2 6
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1016/j.bmcl.2006.11.093
CHEMBL201170 73177 None 0 Human Binding pKi = 8.8 8.8 -2 6
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1016/j.bmcl.2006.11.093
11558055 73177 None 0 Human Binding pKi = 8.8 8.8 -2 6
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm070388+
CHEMBL1204122 73177 None 0 Human Binding pKi = 8.8 8.8 -2 6
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm070388+
CHEMBL201170 73177 None 0 Human Binding pKi = 8.8 8.8 -2 6
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm070388+
11558055 73177 None 0 Human Binding pKi = 8.8 8.8 -2 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1016/j.bmc.2009.08.028
CHEMBL1204122 73177 None 0 Human Binding pKi = 8.8 8.8 -2 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1016/j.bmc.2009.08.028
CHEMBL201170 73177 None 0 Human Binding pKi = 8.8 8.8 -2 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1016/j.bmc.2009.08.028
11558055 73177 None 0 Human Binding pKi = 8.8 8.8 -2 6
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm050846j
CHEMBL1204122 73177 None 0 Human Binding pKi = 8.8 8.8 -2 6
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm050846j
CHEMBL201170 73177 None 0 Human Binding pKi = 8.8 8.8 -2 6
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm050846j
11623343 140929 None 0 Human Binding pKi = 8.8 8.8 2 4
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 283 0 2 3 2.7 CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1 10.1021/jm051237e
CHEMBL381936 140929 None 0 Human Binding pKi = 8.8 8.8 2 4
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 283 0 2 3 2.7 CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1 10.1021/jm051237e
1243 3618 None 30 Human Binding pKi = 8.8 8.8 -2 15
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 331 1 1 2 3.8 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O 10.1016/j.bmcl.2021.128047
944 3618 None 30 Human Binding pKi = 8.8 8.8 -2 15
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 331 1 1 2 3.8 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O 10.1016/j.bmcl.2021.128047
CHEMBL324017 3618 None 30 Human Binding pKi = 8.8 8.8 -2 15
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 331 1 1 2 3.8 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O 10.1016/j.bmcl.2021.128047
10402378 66146 None 0 Human Binding pKi = 8.7 8.7 19 5
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 297 1 0 3 3.2 COc1ccc2c(c1)OCCN(C)CCc1ccccc1C2 10.1021/jm049720x
CHEMBL184049 66146 None 0 Human Binding pKi = 8.7 8.7 19 5
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 297 1 0 3 3.2 COc1ccc2c(c1)OCCN(C)CCc1ccccc1C2 10.1021/jm049720x
122205438 137487 None 0 Human Binding pKi = 8.7 8.7 -1 5
Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay
ChEMBL 307 0 0 2 4.5 CN1CCc2ccccc2Cc2sc3ccccc3c2CC1 10.1039/C5MD00258C
CHEMBL3753266 137487 None 0 Human Binding pKi = 8.7 8.7 -1 5
Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay
ChEMBL 307 0 0 2 4.5 CN1CCc2ccccc2Cc2sc3ccccc3c2CC1 10.1039/C5MD00258C
46216855 202834 None 0 Human Binding pKi = 8.7 8.7 -2 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 395 1 1 3 5.7 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccs4)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
CHEMBL597900 202834 None 0 Human Binding pKi = 8.7 8.7 -2 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 395 1 1 3 5.7 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccs4)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
1243 3618 None 30 Human Binding pKi = 8.7 8.7 -2 15
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 331 1 1 2 3.8 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O 10.6019/CHEMBL5442175
944 3618 None 30 Human Binding pKi = 8.7 8.7 -2 15
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 331 1 1 2 3.8 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O 10.6019/CHEMBL5442175
CHEMBL324017 3618 None 30 Human Binding pKi = 8.7 8.7 -2 15
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 331 1 1 2 3.8 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O 10.6019/CHEMBL5442175
46231925 203835 None 0 Human Binding pKi = 8 8.0 -5 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 384 3 1 4 4.4 CCO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C 10.1016/j.bmcl.2009.12.094
CHEMBL604525 203835 None 0 Human Binding pKi = 8 8.0 -5 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 384 3 1 4 4.4 CCO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C 10.1016/j.bmcl.2009.12.094
45379370 7525 None 0 Human Binding pKi = 8.0 8.0 2 5
Displacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation counting
ChEMBL 290 0 1 1 3.8 CN1CCc2ccccc2Cc2c([nH]c3ccccc23)CC1 10.1021/jm901291r
CHEMBL1087301 7525 None 0 Human Binding pKi = 8.0 8.0 2 5
Displacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation counting
ChEMBL 290 0 1 1 3.8 CN1CCc2ccccc2Cc2c([nH]c3ccccc23)CC1 10.1021/jm901291r
11269330 203950 None 0 Human Binding pKi = 8.0 8.0 -34 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 390 1 1 3 5.0 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccncc4)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
CHEMBL605127 203950 None 0 Human Binding pKi = 8.0 8.0 -34 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 390 1 1 3 5.0 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccncc4)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
135398745 2914 None 65 Human Binding pKi = 7 7.0 -26 65
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1039/C2MD00311B
135398745.0 2914 None 65 Human Binding pKi = 7 7.0 -26 65
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1039/C2MD00311B
47 2914 None 65 Human Binding pKi = 7 7.0 -26 65
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1039/C2MD00311B
CHEMBL715 2914 None 65 Human Binding pKi = 7 7.0 -26 65
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1039/C2MD00311B
DB00334 2914 None 65 Human Binding pKi = 7 7.0 -26 65
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1039/C2MD00311B
10947658 28710 None 0 Human Binding pKi = 6 6.0 -912 16
Binding affinity against Dopamine receptor D5Binding affinity against Dopamine receptor D5
ChEMBL 335 1 1 2 3.0 C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 10.1021/jm020153s
CHEMBL137781 28710 None 0 Human Binding pKi = 6 6.0 -912 16
Binding affinity against Dopamine receptor D5Binding affinity against Dopamine receptor D5
ChEMBL 335 1 1 2 3.0 C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 10.1021/jm020153s
135398737 958 None 57 Human Binding pKi = 6 6.0 -89 91
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C2MD00311B
135398737.0 958 None 57 Human Binding pKi = 6 6.0 -89 91
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C2MD00311B
38 958 None 57 Human Binding pKi = 6 6.0 -89 91
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C2MD00311B
722 958 None 57 Human Binding pKi = 6 6.0 -89 91
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C2MD00311B
CHEMBL42 958 None 57 Human Binding pKi = 6 6.0 -89 91
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C2MD00311B
DB00363 958 None 57 Human Binding pKi = 6 6.0 -89 91
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C2MD00311B
2389 3331 None 72 Human Binding pKi = 6 6.0 -234 67
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1039/C2MD00311B
5073 3331 None 72 Human Binding pKi = 6 6.0 -234 67
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1039/C2MD00311B
5073.0 3331 None 72 Human Binding pKi = 6 6.0 -234 67
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1039/C2MD00311B
96 3331 None 72 Human Binding pKi = 6 6.0 -234 67
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1039/C2MD00311B
CHEMBL85 3331 None 72 Human Binding pKi = 6 6.0 -234 67
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1039/C2MD00311B
DB00734 3331 None 72 Human Binding pKi = 6 6.0 -234 67
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1039/C2MD00311B
155552185 174165 None 0 Human Binding pKi = 6 6.0 -1819 16
Displacement of [3H] SCH23390 from D5 receptor (unknown origin)Displacement of [3H] SCH23390 from D5 receptor (unknown origin)
ChEMBL 491 10 2 5 4.3 COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1 10.1021/acs.jmedchem.9b01085
CHEMBL4544086 174165 None 0 Human Binding pKi = 6 6.0 -1819 16
Displacement of [3H] SCH23390 from D5 receptor (unknown origin)Displacement of [3H] SCH23390 from D5 receptor (unknown origin)
ChEMBL 491 10 2 5 4.3 COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1 10.1021/acs.jmedchem.9b01085
154724609 176704 None 1 Human Binding pKi = 6 6.0 -11 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 440 10 0 6 4.8 COc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C 10.1021/acs.jmedchem.9b01835
CHEMBL4514800 176704 None 1 Human Binding pKi = 6 6.0 -11 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 440 10 0 6 4.8 COc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C 10.1021/acs.jmedchem.9b01835
CHEMBL4597637 176704 None 1 Human Binding pKi = 6 6.0 -11 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 440 10 0 6 4.8 COc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C 10.1021/acs.jmedchem.9b01835
45376872 70100 None 20 Human Binding pKi = 5 5.0 - 1
GPCRScan assay: inhibition of D5GPCRScan assay: inhibition of D5
ChEMBL 446 7 3 6 3.4 CCOC(=O)c1cc2cc(-c3cc(C(=O)NCc4ccc(C(=O)O)cc4)nn3C)ccc2[nH]1 10.6019/CHEMBL4507281
CHEMBL1939876 70100 None 20 Human Binding pKi = 5 5.0 - 1
GPCRScan assay: inhibition of D5GPCRScan assay: inhibition of D5
ChEMBL 446 7 3 6 3.4 CCOC(=O)c1cc2cc(-c3cc(C(=O)NCc4ccc(C(=O)O)cc4)nn3C)ccc2[nH]1 10.6019/CHEMBL4507281
56850410 70102 None 0 Human Binding pKi = 5 5.0 - 1
GPCRScan assay: inhibition of D5GPCRScan assay: inhibition of D5
ChEMBL 374 5 3 4 3.2 Cn1nc(C(=O)NCc2ccc(C(=O)O)cc2)cc1-c1ccc2[nH]ccc2c1 10.6019/CHEMBL4507281
CHEMBL1939880 70102 None 0 Human Binding pKi = 5 5.0 - 1
GPCRScan assay: inhibition of D5GPCRScan assay: inhibition of D5
ChEMBL 374 5 3 4 3.2 Cn1nc(C(=O)NCc2ccc(C(=O)O)cc2)cc1-c1ccc2[nH]ccc2c1 10.6019/CHEMBL4507281
72901200 119841 None 26 Human Binding pKi = 5 5.0 -6918 33
GPCRScan assay: inhibition of D5GPCRScan assay: inhibition of D5
ChEMBL 322 7 2 4 3.8 Cc1ccc2nc(CNCCCOc3ccccc3)cc(O)c2c1 10.6019/CHEMBL4507309
CHEMBL3480577 119841 None 26 Human Binding pKi = 5 5.0 -6918 33
GPCRScan assay: inhibition of D5GPCRScan assay: inhibition of D5
ChEMBL 322 7 2 4 3.8 Cc1ccc2nc(CNCCCOc3ccccc3)cc(O)c2c1 10.6019/CHEMBL4507309
CHEMBL4522773 216443 None 0 Human Binding pKi = 5 5.0 -15 3
GPCRScan assay: inhibition of D5GPCRScan assay: inhibition of D5
ChEMBL None None None CC1=C(C#N)[C@@H](c2ccc3[nH]nc(C)c3c2)C(C#N)=C(c2ccc(Cl)cc2)N1 10.6019/CHEMBL4507263
145969667 165060 None 0 Human Binding pKi = 7 7.0 -41 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 289 9 1 2 4.9 CCCCCCCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
CHEMBL4225278 165060 None 0 Human Binding pKi = 7 7.0 -41 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 289 9 1 2 4.9 CCCCCCCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
681 1465 None 47 Human Binding pKi = 6.0 6.0 -67 38
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm401384w
681.0 1465 None 47 Human Binding pKi = 6.0 6.0 -67 38
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm401384w
940 1465 None 47 Human Binding pKi = 6.0 6.0 -67 38
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm401384w
947 1465 None 47 Human Binding pKi = 6.0 6.0 -67 38
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm401384w
CHEMBL59 1465 None 47 Human Binding pKi = 6.0 6.0 -67 38
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm401384w
DB00988 1465 None 47 Human Binding pKi = 6.0 6.0 -67 38
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm401384w
21527771 70180 None 1 Human Binding pKi = 7.0 7.0 -40 10
Displacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation counting
ChEMBL 363 6 1 3 4.2 OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.07.018
CHEMBL1940404 70180 None 1 Human Binding pKi = 7.0 7.0 -40 10
Displacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation counting
ChEMBL 363 6 1 3 4.2 OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.07.018
172463952 196538 None 0 Human Binding pKi = 6.0 6.0 -91 8
Displacement of [3H]N-methylspiperone from Dopamine D5 receptor (unknown origin) expressed in HEK293T cell membrane incubated for 2 hrs by radioligand competitive binding based MicroBeta TriLux reader methodDisplacement of [3H]N-methylspiperone from Dopamine D5 receptor (unknown origin) expressed in HEK293T cell membrane incubated for 2 hrs by radioligand competitive binding based MicroBeta TriLux reader method
ChEMBL 418 7 1 5 4.5 COc1cccc2c3c(oc12)CN(CCCCOc1ccc2ccc(=O)[nH]c2c1)CC3 10.1021/acs.jmedchem.3c00098
CHEMBL5426242 196538 None 0 Human Binding pKi = 6.0 6.0 -91 8
Displacement of [3H]N-methylspiperone from Dopamine D5 receptor (unknown origin) expressed in HEK293T cell membrane incubated for 2 hrs by radioligand competitive binding based MicroBeta TriLux reader methodDisplacement of [3H]N-methylspiperone from Dopamine D5 receptor (unknown origin) expressed in HEK293T cell membrane incubated for 2 hrs by radioligand competitive binding based MicroBeta TriLux reader method
ChEMBL 418 7 1 5 4.5 COc1cccc2c3c(oc12)CN(CCCCOc1ccc2ccc(=O)[nH]c2c1)CC3 10.1021/acs.jmedchem.3c00098
172463952 196538 None 0 Human Binding pKi = 6.0 6.0 -91 8
Displacement of [3H]N-methylspiperone from Dopamine D5 receptor (unknown origin) expressed in HEK293T cell membrane incubated for 2 hrs by radioligand competitive binding based MicroBeta TriLux reader methodDisplacement of [3H]N-methylspiperone from Dopamine D5 receptor (unknown origin) expressed in HEK293T cell membrane incubated for 2 hrs by radioligand competitive binding based MicroBeta TriLux reader method
ChEMBL 418 7 1 5 4.5 COc1cccc2c3c(oc12)CN(CCCCOc1ccc2ccc(=O)[nH]c2c1)CC3 10.1021/acs.jmedchem.3c00098
CHEMBL5426242 196538 None 0 Human Binding pKi = 6.0 6.0 -91 8
Displacement of [3H]N-methylspiperone from Dopamine D5 receptor (unknown origin) expressed in HEK293T cell membrane incubated for 2 hrs by radioligand competitive binding based MicroBeta TriLux reader methodDisplacement of [3H]N-methylspiperone from Dopamine D5 receptor (unknown origin) expressed in HEK293T cell membrane incubated for 2 hrs by radioligand competitive binding based MicroBeta TriLux reader method
ChEMBL 418 7 1 5 4.5 COc1cccc2c3c(oc12)CN(CCCCOc1ccc2ccc(=O)[nH]c2c1)CC3 10.1021/acs.jmedchem.3c00098
42611190 3156 None 14 Human Binding pKi = 6.0 6.0 -4265 22
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 475 4 2 2 7.4 OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F 10.6019/CHEMBL5442175
5802 3156 None 14 Human Binding pKi = 6.0 6.0 -4265 22
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 475 4 2 2 7.4 OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F 10.6019/CHEMBL5442175
CHEMBL1800685 3156 None 14 Human Binding pKi = 6.0 6.0 -4265 22
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 475 4 2 2 7.4 OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F 10.6019/CHEMBL5442175
44415593 80278 None 0 Human Binding pKi = 7.0 7.0 -104 6
Binding affinity at dopamine D5 receptorBinding affinity at dopamine D5 receptor
ChEMBL 495 2 1 5 5.6 CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc4ccccc34)c3ccccc32)CC1 10.1016/j.bmcl.2006.06.022
CHEMBL213834 80278 None 0 Human Binding pKi = 7.0 7.0 -104 6
Binding affinity at dopamine D5 receptorBinding affinity at dopamine D5 receptor
ChEMBL 495 2 1 5 5.6 CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc4ccccc34)c3ccccc32)CC1 10.1016/j.bmcl.2006.06.022
242 470 None 70 Human Binding pKi = 6.0 6.0 -380 51
Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl nan
34 470 None 70 Human Binding pKi = 6.0 6.0 -380 51
Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl nan
60795 470 None 70 Human Binding pKi = 6.0 6.0 -380 51
Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl nan
60795.0 470 None 70 Human Binding pKi = 6.0 6.0 -380 51
Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl nan
CHEMBL1112 470 None 70 Human Binding pKi = 6.0 6.0 -380 51
Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl nan
DB01238 470 None 70 Human Binding pKi = 6.0 6.0 -380 51
Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl nan
154704368 176576 None 1 Human Binding pKi = 5.0 5.0 -229 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 421 11 2 2 5.3 CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(F)cc1 10.1021/acs.jmedchem.9b01835
CHEMBL4569006 176576 None 1 Human Binding pKi = 5.0 5.0 -229 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 421 11 2 2 5.3 CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(F)cc1 10.1021/acs.jmedchem.9b01835
CHEMBL4596571 176576 None 1 Human Binding pKi = 5.0 5.0 -229 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 421 11 2 2 5.3 CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(F)cc1 10.1021/acs.jmedchem.9b01835
126720252 164770 None 0 Human Binding pKi = 6.0 6.0 -38 13
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting method
ChEMBL 697 15 2 6 9.2 NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1 10.1021/acs.jmedchem.8b00168
CHEMBL4216870 164770 None 0 Human Binding pKi = 6.0 6.0 -38 13
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting method
ChEMBL 697 15 2 6 9.2 NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1 10.1021/acs.jmedchem.8b00168
130 3500 None 32 Human Binding pKi = 6.0 6.0 -295 21
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 520 3 0 6 5.6 CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C 10.6019/CHEMBL5442175
3378093 3500 None 32 Human Binding pKi = 6.0 6.0 -295 21
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 520 3 0 6 5.6 CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C 10.6019/CHEMBL5442175
CHEMBL281350 3500 None 32 Human Binding pKi = 6.0 6.0 -295 21
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 520 3 0 6 5.6 CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C 10.6019/CHEMBL5442175
11566745 74720 None 0 Human Binding pKi = 6.0 6.0 1 4
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 283 0 2 3 2.7 CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1 10.1021/jm050846j
CHEMBL1202298 74720 None 0 Human Binding pKi = 6.0 6.0 1 4
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 283 0 2 3 2.7 CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1 10.1021/jm050846j
CHEMBL203029 74720 None 0 Human Binding pKi = 6.0 6.0 1 4
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 283 0 2 3 2.7 CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1 10.1021/jm050846j
154704418 176692 None 1 Human Binding pKi = 6.0 6.0 -2 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 458 12 1 6 4.8 Cn1c(SCCCNCC2CC2c2cc(F)ccc2OCCF)nnc1-c1ccccc1 10.1021/acs.jmedchem.9b01835
CHEMBL4546749 176692 None 1 Human Binding pKi = 6.0 6.0 -2 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 458 12 1 6 4.8 Cn1c(SCCCNCC2CC2c2cc(F)ccc2OCCF)nnc1-c1ccccc1 10.1021/acs.jmedchem.9b01835
CHEMBL4597533 176692 None 1 Human Binding pKi = 6.0 6.0 -2 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 458 12 1 6 4.8 Cn1c(SCCCNCC2CC2c2cc(F)ccc2OCCF)nnc1-c1ccccc1 10.1021/acs.jmedchem.9b01835
11408135 124255 None 0 Rat Binding pKi = 5.0 5.0 -245 3
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 443 7 1 4 4.5 COc1ccc2c(c1)N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@H]1CC2 10.1021/jm049031l
CHEMBL363406 124255 None 0 Rat Binding pKi = 5.0 5.0 -245 3
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 443 7 1 4 4.5 COc1ccc2c(c1)N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@H]1CC2 10.1021/jm049031l
5249956 73420 None 0 Human Binding pKi = 8.0 8.0 -2 6
Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay
ChEMBL 251 0 0 1 3.3 CN1CCc2ccccc2Cc2ccccc2CC1 10.1039/C5MD00258C
CHEMBL201525 73420 None 0 Human Binding pKi = 8.0 8.0 -2 6
Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay
ChEMBL 251 0 0 1 3.3 CN1CCc2ccccc2Cc2ccccc2CC1 10.1039/C5MD00258C
5249956 73420 None 0 Human Binding pKi = 8.0 8.0 -2 6
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 251 0 0 1 3.3 CN1CCc2ccccc2Cc2ccccc2CC1 10.1016/j.bmcl.2006.11.093
CHEMBL201525 73420 None 0 Human Binding pKi = 8.0 8.0 -2 6
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 251 0 0 1 3.3 CN1CCc2ccccc2Cc2ccccc2CC1 10.1016/j.bmcl.2006.11.093
5249956 73420 None 0 Human Binding pKi = 8.0 8.0 -2 6
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 251 0 0 1 3.3 CN1CCc2ccccc2Cc2ccccc2CC1 10.1021/jm050846j
CHEMBL201525 73420 None 0 Human Binding pKi = 8.0 8.0 -2 6
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 251 0 0 1 3.3 CN1CCc2ccccc2Cc2ccccc2CC1 10.1021/jm050846j
56594534 70624 None 0 Human Binding pKi = 7.9 7.9 -1 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cells
ChEMBL 320 1 2 2 3.2 CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@@H]1CO 10.1021/jm200676f
CHEMBL1949728 70624 None 0 Human Binding pKi = 7.9 7.9 -1 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cells
ChEMBL 320 1 2 2 3.2 CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@@H]1CO 10.1021/jm200676f
56597938 3940 None 4 Human Binding pKi = 6.0 6.0 -1380 9
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 461 7 1 4 5.2 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl 10.1021/acs.jmedchem.7b00363
7651 3940 None 4 Human Binding pKi = 6.0 6.0 -1380 9
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 461 7 1 4 5.2 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl 10.1021/acs.jmedchem.7b00363
CHEMBL2165126 3940 None 4 Human Binding pKi = 6.0 6.0 -1380 9
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 461 7 1 4 5.2 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl 10.1021/acs.jmedchem.7b00363
164618319 184699 None 0 Human Binding pKi = 6.0 6.0 1 3
Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)
ChEMBL 340 2 1 4 2.1 CC(=O)NCC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 10.1016/j.bmcl.2021.128008
CHEMBL4848838 184699 None 0 Human Binding pKi = 6.0 6.0 1 3
Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)
ChEMBL 340 2 1 4 2.1 CC(=O)NCC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 10.1016/j.bmcl.2021.128008
122181333 121940 None 0 Human Binding pKi = 5.0 5.0 -7762 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranes
ChEMBL 366 8 1 2 3.8 CCCN(CCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1 10.1016/j.bmc.2014.12.012
CHEMBL3590084 121940 None 0 Human Binding pKi = 5.0 5.0 -7762 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranes
ChEMBL 366 8 1 2 3.8 CCCN(CCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1 10.1016/j.bmc.2014.12.012
154725276 176395 None 1 Human Binding pKi = 6.0 6.0 -40 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 478 12 1 3 6.5 CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC 10.1021/acs.jmedchem.9b01835
CHEMBL4456964 176395 None 1 Human Binding pKi = 6.0 6.0 -40 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 478 12 1 3 6.5 CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC 10.1021/acs.jmedchem.9b01835
CHEMBL4595147 176395 None 1 Human Binding pKi = 6.0 6.0 -40 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 478 12 1 3 6.5 CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC 10.1021/acs.jmedchem.9b01835
11335419 67121 None 0 Human Binding pKi = 7.0 7.0 -11 6
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 295 7 0 2 4.1 c1ccc(Cc2ccccc2OCCCN2CCCC2)cc1 10.1021/jm049720x
CHEMBL187367 67121 None 0 Human Binding pKi = 7.0 7.0 -11 6
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 295 7 0 2 4.1 c1ccc(Cc2ccccc2OCCCN2CCCC2)cc1 10.1021/jm049720x
21533446 70179 None 0 Human Binding pKi = 7.0 7.0 -30 10
Displacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation counting
ChEMBL 379 6 1 3 4.9 OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.07.018
CHEMBL1940403 70179 None 0 Human Binding pKi = 7.0 7.0 -30 10
Displacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation counting
ChEMBL 379 6 1 3 4.9 OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.07.018
44436302 90668 None 0 Human Binding pKi = 6.0 6.0 -23 4
Binding affinity to human D5RBinding affinity to human D5R
ChEMBL 429 7 0 6 2.4 COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 10.1016/j.bmcl.2021.128028
CHEMBL238917 90668 None 0 Human Binding pKi = 6.0 6.0 -23 4
Binding affinity to human D5RBinding affinity to human D5R
ChEMBL 429 7 0 6 2.4 COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 10.1016/j.bmcl.2021.128028
44436302 90668 None 0 Human Binding pKi = 6.0 6.0 -23 4
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 429 7 0 6 2.4 COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 10.1016/j.bmc.2007.06.002
CHEMBL238917 90668 None 0 Human Binding pKi = 6.0 6.0 -23 4
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 429 7 0 6 2.4 COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 10.1016/j.bmc.2007.06.002
681 1465 None 47 Human Binding pKi = 5.9 5.9 -67 38
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm401384w
681.0 1465 None 47 Human Binding pKi = 5.9 5.9 -67 38
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm401384w
940 1465 None 47 Human Binding pKi = 5.9 5.9 -67 38
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm401384w
947 1465 None 47 Human Binding pKi = 5.9 5.9 -67 38
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm401384w
CHEMBL59 1465 None 47 Human Binding pKi = 5.9 5.9 -67 38
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm401384w
DB00988 1465 None 47 Human Binding pKi = 5.9 5.9 -67 38
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm401384w
11573806 75443 None 0 Human Binding pKi = 7.9 7.9 -6 4
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 311 2 0 3 3.3 COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2 10.1021/jm051237e
CHEMBL204065 75443 None 0 Human Binding pKi = 7.9 7.9 -6 4
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 311 2 0 3 3.3 COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2 10.1021/jm051237e
11151831 13125 None 0 Human Binding pKi = 4.9 4.9 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 299 4 1 2 3.9 CCCN(C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1190453 13125 None 0 Human Binding pKi = 4.9 4.9 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 299 4 1 2 3.9 CCCN(C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL540868 13125 None 0 Human Binding pKi = 4.9 4.9 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 299 4 1 2 3.9 CCCN(C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
154706513 176691 None 1 Human Binding pKi = 5.9 5.9 -18 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 480 12 0 6 5.6 COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1 10.1021/acs.jmedchem.9b01835
CHEMBL4440698 176691 None 1 Human Binding pKi = 5.9 5.9 -18 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 480 12 0 6 5.6 COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1 10.1021/acs.jmedchem.9b01835
CHEMBL4597532 176691 None 1 Human Binding pKi = 5.9 5.9 -18 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 480 12 0 6 5.6 COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1 10.1021/acs.jmedchem.9b01835
53324045 57087 None 0 Human Binding pKi = 6.9 6.9 -3 16
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assay
ChEMBL 487 7 1 2 7.3 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 10.1016/j.bmcl.2018.10.036
CHEMBL1644980 57087 None 0 Human Binding pKi = 6.9 6.9 -3 16
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assay
ChEMBL 487 7 1 2 7.3 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 10.1016/j.bmcl.2018.10.036
3038495 708 None 33 Human Binding pKi = 5.9 5.9 -1047 27
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 417 8 1 4 4.2 COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 10.1021/acs.jmedchem.9b01835
7625 708 None 33 Human Binding pKi = 5.9 5.9 -1047 27
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 417 8 1 4 4.2 COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 10.1021/acs.jmedchem.9b01835
CHEMBL25236 708 None 33 Human Binding pKi = 5.9 5.9 -1047 27
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 417 8 1 4 4.2 COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 10.1021/acs.jmedchem.9b01835
1242 3613 None 17 Human Binding pKi = 6.9 6.9 -6 17
Displacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation counting
ChEMBL 255 1 3 3 2.4 Oc1cc2CCNCC(c2cc1O)c1ccccc1 10.1016/j.bmc.2011.08.033
935 3613 None 17 Human Binding pKi = 6.9 6.9 -6 17
Displacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation counting
ChEMBL 255 1 3 3 2.4 Oc1cc2CCNCC(c2cc1O)c1ccccc1 10.1016/j.bmc.2011.08.033
CHEMBL286080 3613 None 17 Human Binding pKi = 6.9 6.9 -6 17
Displacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation counting
ChEMBL 255 1 3 3 2.4 Oc1cc2CCNCC(c2cc1O)c1ccccc1 10.1016/j.bmc.2011.08.033
487 3634 None 20 Human Binding pKi = 5.9 5.9 -3235 28
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.6019/CHEMBL5442175
60602 3634 None 20 Human Binding pKi = 5.9 5.9 -3235 28
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.6019/CHEMBL5442175
CHEMBL405355 3634 None 20 Human Binding pKi = 5.9 5.9 -3235 28
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.6019/CHEMBL5442175
DB09239 3634 None 20 Human Binding pKi = 5.9 5.9 -3235 28
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.6019/CHEMBL5442175
33630 179063 None 62 Human Binding pKi = 6.9 6.9 -5 27
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assay
ChEMBL 523 7 1 2 7.5 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1016/j.bmcl.2018.10.036
CHEMBL47050 179063 None 62 Human Binding pKi = 6.9 6.9 -5 27
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assay
ChEMBL 523 7 1 2 7.5 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1016/j.bmcl.2018.10.036
164609730 185205 None 0 Human Binding pKi = 5.9 5.9 -1 3
Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)
ChEMBL 398 2 1 5 3.5 CC(C)(C)OC(=O)NCC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 10.1016/j.bmcl.2021.128008
CHEMBL4856060 185205 None 0 Human Binding pKi = 5.9 5.9 -1 3
Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)
ChEMBL 398 2 1 5 3.5 CC(C)(C)OC(=O)NCC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 10.1016/j.bmcl.2021.128008
11154178 202682 None 0 Human Binding pKi = 7.9 7.9 -64 3
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 412 4 1 3 4.6 CC(=O)N(Cc1ccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)cc1)C1CCC1 10.1016/j.bmcl.2009.12.100
CHEMBL596824 202682 None 0 Human Binding pKi = 7.9 7.9 -64 3
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 412 4 1 3 4.6 CC(=O)N(Cc1ccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)cc1)C1CCC1 10.1016/j.bmcl.2009.12.100
122191607 123789 None 0 Human Binding pKi = 5.9 5.9 -1778 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 468 9 1 3 5.0 CCCN(CCN1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1 10.1021/acsmedchemlett.5b00131
CHEMBL3622099 123789 None 0 Human Binding pKi = 5.9 5.9 -1778 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 468 9 1 3 5.0 CCCN(CCN1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1 10.1021/acsmedchemlett.5b00131
137654675 158726 None 0 Human Binding pKi = 4.9 4.9 -3388 6
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 433 7 2 7 2.9 O=c1ccc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2[nH]1 10.1021/acs.jmedchem.7b00363
CHEMBL4092441 158726 None 0 Human Binding pKi = 4.9 4.9 -3388 6
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 433 7 2 7 2.9 O=c1ccc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2[nH]1 10.1021/acs.jmedchem.7b00363
11739113 13102 None 0 Human Binding pKi = 4.9 4.9 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 297 4 1 2 3.7 C=CCN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1190331 13102 None 0 Human Binding pKi = 4.9 4.9 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 297 4 1 2 3.7 C=CCN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL540613 13102 None 0 Human Binding pKi = 4.9 4.9 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 297 4 1 2 3.7 C=CCN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
57391216 70192 None 0 Human Binding pKi = 5.9 5.9 -66 8
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 332 6 0 5 2.9 Fc1ccc(SCCCN2CCN(c3ncccn3)CC2)cc1 10.1016/j.bmc.2014.04.026
CHEMBL1940416 70192 None 0 Human Binding pKi = 5.9 5.9 -66 8
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 332 6 0 5 2.9 Fc1ccc(SCCCN2CCN(c3ncccn3)CC2)cc1 10.1016/j.bmc.2014.04.026
11716449 141302 None 0 Human Binding pKi = 7.8 7.8 2 4
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 304 1 1 1 4.2 CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm050846j
CHEMBL382850 141302 None 0 Human Binding pKi = 7.8 7.8 2 4
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 304 1 1 1 4.2 CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm050846j
164609539 184505 None 0 Human Binding pKi = 5.9 5.9 -2 3
Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)
ChEMBL 428 2 0 5 3.3 O=C1c2ccccc2C(=O)N1CC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 10.1016/j.bmcl.2021.128008
CHEMBL4845850 184505 None 0 Human Binding pKi = 5.9 5.9 -2 3
Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)
ChEMBL 428 2 0 5 3.3 O=C1c2ccccc2C(=O)N1CC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 10.1016/j.bmcl.2021.128008
145988180 165326 None 0 Human Binding pKi = 6.8 6.8 -12 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 303 10 1 2 5.3 CCCCCCCCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
CHEMBL4229178 165326 None 0 Human Binding pKi = 6.8 6.8 -12 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 303 10 1 2 5.3 CCCCCCCCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
164585473 184668 None 0 Human Binding pKi = 5.8 5.8 -2 5
Binding affinity to D5 receptor (unknown origin)Binding affinity to D5 receptor (unknown origin)
ChEMBL 503 5 1 2 7.2 O=CN1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1 10.1021/acs.jmedchem.1c00164
CHEMBL4848380 184668 None 0 Human Binding pKi = 5.8 5.8 -2 5
Binding affinity to D5 receptor (unknown origin)Binding affinity to D5 receptor (unknown origin)
ChEMBL 503 5 1 2 7.2 O=CN1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1 10.1021/acs.jmedchem.1c00164
44209480 70194 None 0 Human Binding pKi = 5.8 5.8 -1318 11
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 313 6 0 3 3.4 Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmc.2014.04.026
CHEMBL1940418 70194 None 0 Human Binding pKi = 5.8 5.8 -1318 11
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 313 6 0 3 3.4 Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmc.2014.04.026
11637457 73112 None 0 Human Binding pKi = 7.8 7.8 -1 5
Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay
ChEMBL 257 0 0 2 3.4 CN1CCc2ccccc2Cc2ccsc2CC1 10.1039/C5MD00258C
CHEMBL201093 73112 None 0 Human Binding pKi = 7.8 7.8 -1 5
Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay
ChEMBL 257 0 0 2 3.4 CN1CCc2ccccc2Cc2ccsc2CC1 10.1039/C5MD00258C
228 445 None 20 Human Binding pKi = 7.8 7.8 -3 24
Displacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1016/j.bmcl.2020.127053
33 445 None 20 Human Binding pKi = 7.8 7.8 -3 24
Displacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1016/j.bmcl.2020.127053
6005 445 None 20 Human Binding pKi = 7.8 7.8 -3 24
Displacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1016/j.bmcl.2020.127053
6005.0 445 None 20 Human Binding pKi = 7.8 7.8 -3 24
Displacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1016/j.bmcl.2020.127053
CHEMBL53 445 None 20 Human Binding pKi = 7.8 7.8 -3 24
Displacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1016/j.bmcl.2020.127053
DB00714 445 None 20 Human Binding pKi = 7.8 7.8 -3 24
Displacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1016/j.bmcl.2020.127053
3246443 37697 None 0 Human Binding pKi = 7.8 7.8 -2 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hr
ChEMBL 325 1 1 5 2.8 COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4 10.1016/j.bmcl.2017.01.090
CHEMBL1457510 37697 None 0 Human Binding pKi = 7.8 7.8 -2 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hr
ChEMBL 325 1 1 5 2.8 COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4 10.1016/j.bmcl.2017.01.090
137636066 156324 None 0 Human Binding pKi = 4.8 4.8 -9549 6
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 480 7 3 7 3.0 O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1 10.1021/acs.jmedchem.7b00363
CHEMBL4064742 156324 None 0 Human Binding pKi = 4.8 4.8 -9549 6
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 480 7 3 7 3.0 O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1 10.1021/acs.jmedchem.7b00363
11439436 12798 None 0 Human Binding pKi = 4.8 4.8 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 311 5 0 2 4.0 C=CCN(C)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1188091 12798 None 0 Human Binding pKi = 4.8 4.8 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 311 5 0 2 4.0 C=CCN(C)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL535151 12798 None 0 Human Binding pKi = 4.8 4.8 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 311 5 0 2 4.0 C=CCN(C)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
46227284 202171 None 0 Human Binding pKi = 5.8 5.8 1 2
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 281 1 0 2 3.5 COc1ccc2c(c1)CCN(C)Cc1ccccc1CC2 10.1016/j.bmc.2009.08.028
CHEMBL593394 202171 None 0 Human Binding pKi = 5.8 5.8 1 2
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 281 1 0 2 3.5 COc1ccc2c(c1)CCN(C)Cc1ccccc1CC2 10.1016/j.bmc.2009.08.028
90644071 112105 None 0 Human Binding pKi = 5.8 5.8 -8 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 368 5 0 3 5.2 Clc1ccc(N2CCCN(CCCc3cc4ccccc4o3)CC2)cc1 10.1016/j.bmc.2014.04.026
CHEMBL3289655 112105 None 0 Human Binding pKi = 5.8 5.8 -8 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 368 5 0 3 5.2 Clc1ccc(N2CCCN(CCCc3cc4ccccc4o3)CC2)cc1 10.1016/j.bmc.2014.04.026
45379377 7459 None 0 Human Binding pKi = 5.8 5.8 1 3
Displacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation counting
ChEMBL 274 0 1 1 3.7 c1ccc2c(c1)CCN1CCc3cccc4[nH]cc(c34)C21 10.1021/jm901291r
CHEMBL1086790 7459 None 0 Human Binding pKi = 5.8 5.8 1 3
Displacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation counting
ChEMBL 274 0 1 1 3.7 c1ccc2c(c1)CCN1CCc3cccc4[nH]cc(c34)C21 10.1021/jm901291r
44591134 176304 None 0 Human Binding pKi = 6.8 6.8 -125 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 535 11 0 5 7.7 CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1 10.1016/j.bmcl.2008.09.012
CHEMBL459373 176304 None 0 Human Binding pKi = 6.8 6.8 -125 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 535 11 0 5 7.7 CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1 10.1016/j.bmcl.2008.09.012
72164182 92184 None 0 Human Binding pKi = 5.8 5.8 -25 5
Binding affinity to human dopamine D5 receptor by radioligand binding assayBinding affinity to human dopamine D5 receptor by radioligand binding assay
ChEMBL 326 3 0 3 4.4 Clc1ccc(N2CCN(Cc3cccs3)CC2)cc1Cl 10.1016/j.bmcl.2013.07.033
CHEMBL2420777 92184 None 0 Human Binding pKi = 5.8 5.8 -25 5
Binding affinity to human dopamine D5 receptor by radioligand binding assayBinding affinity to human dopamine D5 receptor by radioligand binding assay
ChEMBL 326 3 0 3 4.4 Clc1ccc(N2CCN(Cc3cccs3)CC2)cc1Cl 10.1016/j.bmcl.2013.07.033
150860015 195040 None 0 Human Binding pKi = 5.8 5.8 -7 17
Binding affinity to dopamine D5 receptor (unknown origin) assessed as inhibition constantBinding affinity to dopamine D5 receptor (unknown origin) assessed as inhibition constant
ChEMBL 440 10 2 6 4.9 CCN(CC)CCCC(C)Nc1cnc(C(=O)Nc2ccc(Cl)c3cccnc23)cn1 10.1021/acs.jmedchem.2c01769
CHEMBL5395401 195040 None 0 Human Binding pKi = 5.8 5.8 -7 17
Binding affinity to dopamine D5 receptor (unknown origin) assessed as inhibition constantBinding affinity to dopamine D5 receptor (unknown origin) assessed as inhibition constant
ChEMBL 440 10 2 6 4.9 CCN(CC)CCCC(C)Nc1cnc(C(=O)Nc2ccc(Cl)c3cccnc23)cn1 10.1021/acs.jmedchem.2c01769
172450959 195711 None 0 Human Binding pKi = 6.8 6.8 -51 8
Displacement of [3H]N-methylspiperone from Dopamine D5 receptor (unknown origin) expressed in HEK293T cell membrane incubated for 2 hrs by radioligand competitive binding based MicroBeta TriLux reader methodDisplacement of [3H]N-methylspiperone from Dopamine D5 receptor (unknown origin) expressed in HEK293T cell membrane incubated for 2 hrs by radioligand competitive binding based MicroBeta TriLux reader method
ChEMBL 420 7 1 5 4.5 COc1cccc2c3c(oc12)CN(CCCCOc1ccc2c(c1)NC(=O)CC2)CC3 10.1021/acs.jmedchem.3c00098
CHEMBL5409419 195711 None 0 Human Binding pKi = 6.8 6.8 -51 8
Displacement of [3H]N-methylspiperone from Dopamine D5 receptor (unknown origin) expressed in HEK293T cell membrane incubated for 2 hrs by radioligand competitive binding based MicroBeta TriLux reader methodDisplacement of [3H]N-methylspiperone from Dopamine D5 receptor (unknown origin) expressed in HEK293T cell membrane incubated for 2 hrs by radioligand competitive binding based MicroBeta TriLux reader method
ChEMBL 420 7 1 5 4.5 COc1cccc2c3c(oc12)CN(CCCCOc1ccc2c(c1)NC(=O)CC2)CC3 10.1021/acs.jmedchem.3c00098
154703647 176470 None 1 Human Binding pKi = 5.8 5.8 -28 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 468 12 0 6 5.6 CCOc1ccc(F)cc1C1CC1CN(CC)CCCSc1nnc(-c2ccccc2)n1C 10.1021/acs.jmedchem.9b01835
CHEMBL4450429 176470 None 1 Human Binding pKi = 5.8 5.8 -28 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 468 12 0 6 5.6 CCOc1ccc(F)cc1C1CC1CN(CC)CCCSc1nnc(-c2ccccc2)n1C 10.1021/acs.jmedchem.9b01835
CHEMBL4595728 176470 None 1 Human Binding pKi = 5.8 5.8 -28 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 468 12 0 6 5.6 CCOc1ccc(F)cc1C1CC1CN(CC)CCCSc1nnc(-c2ccccc2)n1C 10.1021/acs.jmedchem.9b01835
6603820 95827 None 16 Rat Binding pKi = 7.8 7.8 -1 13
Displacement of [3H]SCH23390 from rat dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from rat dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 267 0 3 3 2.6 Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2 10.1016/j.bmc.2009.08.028
CHEMBL25856 95827 None 16 Rat Binding pKi = 7.8 7.8 -1 13
Displacement of [3H]SCH23390 from rat dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from rat dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 267 0 3 3 2.6 Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2 10.1016/j.bmc.2009.08.028
10200496 83626 None 0 Human Binding pKi = 7.8 7.8 -30 5
Inhibition of human dopamine D5 receptorInhibition of human dopamine D5 receptor
ChEMBL 391 6 1 3 3.6 O=C(CCCN1CC[Si](O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 10.1021/jm1013693
CHEMBL2204343 83626 None 0 Human Binding pKi = 7.8 7.8 -30 5
Inhibition of human dopamine D5 receptorInhibition of human dopamine D5 receptor
ChEMBL 391 6 1 3 3.6 O=C(CCCN1CC[Si](O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 10.1021/jm1013693
242 470 None 70 Human Binding pKi = 5.8 5.8 -380 51
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2017.08.037
34 470 None 70 Human Binding pKi = 5.8 5.8 -380 51
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2017.08.037
60795 470 None 70 Human Binding pKi = 5.8 5.8 -380 51
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2017.08.037
60795.0 470 None 70 Human Binding pKi = 5.8 5.8 -380 51
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2017.08.037
CHEMBL1112 470 None 70 Human Binding pKi = 5.8 5.8 -380 51
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2017.08.037
DB01238 470 None 70 Human Binding pKi = 5.8 5.8 -380 51
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2017.08.037
242 470 None 70 Human Binding pKi = 5.8 5.8 -380 51
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1021/acs.jmedchem.7b00363
34 470 None 70 Human Binding pKi = 5.8 5.8 -380 51
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1021/acs.jmedchem.7b00363
60795 470 None 70 Human Binding pKi = 5.8 5.8 -380 51
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1021/acs.jmedchem.7b00363
60795.0 470 None 70 Human Binding pKi = 5.8 5.8 -380 51
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1021/acs.jmedchem.7b00363
CHEMBL1112 470 None 70 Human Binding pKi = 5.8 5.8 -380 51
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1021/acs.jmedchem.7b00363
DB01238 470 None 70 Human Binding pKi = 5.8 5.8 -380 51
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1021/acs.jmedchem.7b00363
163198500 186504 None 3 Human Binding pKi = 5.8 5.8 3 2
Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)
ChEMBL 371 1 0 3 3.2 O=[N+]([O-])C1=Cc2cc(I)ccc2OC1C(F)(F)F 10.1016/j.bmcl.2021.128008
CHEMBL4875858 186504 None 3 Human Binding pKi = 5.8 5.8 3 2
Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)
ChEMBL 371 1 0 3 3.2 O=[N+]([O-])C1=Cc2cc(I)ccc2OC1C(F)(F)F 10.1016/j.bmcl.2021.128008
137655795 158674 None 0 Human Binding pKi = 4.8 4.8 -6309 6
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 453 7 2 7 3.0 O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc2N1 10.1021/acs.jmedchem.7b00363
CHEMBL4091933 158674 None 0 Human Binding pKi = 4.8 4.8 -6309 6
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 453 7 2 7 3.0 O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc2N1 10.1021/acs.jmedchem.7b00363
137660046 159437 None 0 Human Binding pKi = 4.8 4.8 -22387 6
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 437 7 2 8 2.4 O=C1COc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2N1 10.1021/acs.jmedchem.7b00363
CHEMBL4100183 159437 None 0 Human Binding pKi = 4.8 4.8 -22387 6
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 437 7 2 8 2.4 O=C1COc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2N1 10.1021/acs.jmedchem.7b00363
11324023 12815 None 0 Human Binding pKi = 4.8 4.8 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 299 4 1 2 3.9 CCCN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1188254 12815 None 0 Human Binding pKi = 4.8 4.8 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 299 4 1 2 3.9 CCCN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL535823 12815 None 0 Human Binding pKi = 4.8 4.8 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 299 4 1 2 3.9 CCCN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
11416811 12829 None 0 Human Binding pKi = 4.8 4.8 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 313 5 0 2 4.2 CCCN(C)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1188384 12829 None 0 Human Binding pKi = 4.8 4.8 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 313 5 0 2 4.2 CCCN(C)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL536271 12829 None 0 Human Binding pKi = 4.8 4.8 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 313 5 0 2 4.2 CCCN(C)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
11438636 13124 None 0 Human Binding pKi = 4.8 4.8 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 285 3 0 2 3.5 COc1cc2c(cc1F)C[C@@H](N(C)C)[C@@H]2c1ccccc1 10.1021/jm040889k
CHEMBL1190452 13124 None 0 Human Binding pKi = 4.8 4.8 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 285 3 0 2 3.5 COc1cc2c(cc1F)C[C@@H](N(C)C)[C@@H]2c1ccccc1 10.1021/jm040889k
CHEMBL540867 13124 None 0 Human Binding pKi = 4.8 4.8 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 285 3 0 2 3.5 COc1cc2c(cc1F)C[C@@H](N(C)C)[C@@H]2c1ccccc1 10.1021/jm040889k
11818686 13902 None 0 Human Binding pKi = 4.8 4.8 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 257 2 1 2 2.9 COc1cc2c(cc1F)[C@@H](c1ccccc1)[C@H](N)C2 10.1021/jm040889k
CHEMBL1196231 13902 None 0 Human Binding pKi = 4.8 4.8 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 257 2 1 2 2.9 COc1cc2c(cc1F)[C@@H](c1ccccc1)[C@H](N)C2 10.1021/jm040889k
CHEMBL556194 13902 None 0 Human Binding pKi = 4.8 4.8 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 257 2 1 2 2.9 COc1cc2c(cc1F)[C@@H](c1ccccc1)[C@H](N)C2 10.1021/jm040889k
85658088 165098 None 0 Human Binding pKi = 5.8 5.8 -5 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 219 4 1 2 3.0 CCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
CHEMBL4225830 165098 None 0 Human Binding pKi = 5.8 5.8 -5 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 219 4 1 2 3.0 CCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
172450959 195711 None 0 Human Binding pKi = 6.8 6.8 -51 8
Displacement of [3H]N-methylspiperone from Dopamine D5 receptor (unknown origin) expressed in HEK293T cell membrane incubated for 2 hrs by radioligand competitive binding based MicroBeta TriLux reader methodDisplacement of [3H]N-methylspiperone from Dopamine D5 receptor (unknown origin) expressed in HEK293T cell membrane incubated for 2 hrs by radioligand competitive binding based MicroBeta TriLux reader method
ChEMBL 420 7 1 5 4.5 COc1cccc2c3c(oc12)CN(CCCCOc1ccc2c(c1)NC(=O)CC2)CC3 10.1021/acs.jmedchem.3c00098
CHEMBL5409419 195711 None 0 Human Binding pKi = 6.8 6.8 -51 8
Displacement of [3H]N-methylspiperone from Dopamine D5 receptor (unknown origin) expressed in HEK293T cell membrane incubated for 2 hrs by radioligand competitive binding based MicroBeta TriLux reader methodDisplacement of [3H]N-methylspiperone from Dopamine D5 receptor (unknown origin) expressed in HEK293T cell membrane incubated for 2 hrs by radioligand competitive binding based MicroBeta TriLux reader method
ChEMBL 420 7 1 5 4.5 COc1cccc2c3c(oc12)CN(CCCCOc1ccc2c(c1)NC(=O)CC2)CC3 10.1021/acs.jmedchem.3c00098
44436300 148924 None 0 Human Binding pKi = 5.8 5.8 -64 4
Binding affinity to human D5RBinding affinity to human D5R
ChEMBL 399 6 0 5 2.4 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2021.128028
CHEMBL394110 148924 None 0 Human Binding pKi = 5.8 5.8 -64 4
Binding affinity to human D5RBinding affinity to human D5R
ChEMBL 399 6 0 5 2.4 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2021.128028
44436300 148924 None 0 Human Binding pKi = 5.8 5.8 -64 4
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 399 6 0 5 2.4 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2007.06.002
CHEMBL394110 148924 None 0 Human Binding pKi = 5.8 5.8 -64 4
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 399 6 0 5 2.4 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2007.06.002
17755866 142971 None 0 Human Binding pKi = 7.8 7.8 -1 5
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 281 0 1 2 3.4 CN1CCCc2cc(O)ccc2Cc2ccccc2CC1 10.1021/jm070388+
CHEMBL389356 142971 None 0 Human Binding pKi = 7.8 7.8 -1 5
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 281 0 1 2 3.4 CN1CCCc2cc(O)ccc2Cc2ccccc2CC1 10.1021/jm070388+
180 401 None 38 Human Binding pKi = 6.8 6.8 -112 39
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1016/j.bmcl.2008.09.012
200 401 None 38 Human Binding pKi = 6.8 6.8 -112 39
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1016/j.bmcl.2008.09.012
2160 401 None 38 Human Binding pKi = 6.8 6.8 -112 39
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1016/j.bmcl.2008.09.012
2160.0 401 None 38 Human Binding pKi = 6.8 6.8 -112 39
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1016/j.bmcl.2008.09.012
CHEMBL629 401 None 38 Human Binding pKi = 6.8 6.8 -112 39
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1016/j.bmcl.2008.09.012
DB00321 401 None 38 Human Binding pKi = 6.8 6.8 -112 39
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1016/j.bmcl.2008.09.012
44436305 154493 None 0 Human Binding pKi = 5.8 5.8 -23 3
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 430 6 0 5 4.0 O=c1c2ccccc2ncn1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2007.06.002
CHEMBL398813 154493 None 0 Human Binding pKi = 5.8 5.8 -23 3
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 430 6 0 5 4.0 O=c1c2ccccc2ncn1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2007.06.002
11464115 68656 None 0 Rat Binding pKi = 5.8 5.8 -89 3
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 413 6 1 3 4.5 O=C(NCCCCN1CCN2c3ccccc3CC[C@@H]2C1)c1ccc2ccccc2c1 10.1021/jm049031l
CHEMBL191815 68656 None 0 Rat Binding pKi = 5.8 5.8 -89 3
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 413 6 1 3 4.5 O=C(NCCCCN1CCN2c3ccccc3CC[C@@H]2C1)c1ccc2ccccc2c1 10.1021/jm049031l
2726 919 None 48 Human Binding pKi = 6.8 6.8 -47 72
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmcl.2008.09.012
2726.0 919 None 48 Human Binding pKi = 6.8 6.8 -47 72
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmcl.2008.09.012
621 919 None 48 Human Binding pKi = 6.8 6.8 -47 72
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmcl.2008.09.012
83 919 None 48 Human Binding pKi = 6.8 6.8 -47 72
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmcl.2008.09.012
CHEMBL71 919 None 48 Human Binding pKi = 6.8 6.8 -47 72
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmcl.2008.09.012
DB00477 919 None 48 Human Binding pKi = 6.8 6.8 -47 72
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmcl.2008.09.012
154705520 176365 None 1 Human Binding pKi = 5.8 5.8 -114 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 448 11 1 3 5.6 CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC 10.1021/acs.jmedchem.9b01835
CHEMBL4452683 176365 None 1 Human Binding pKi = 5.8 5.8 -114 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 448 11 1 3 5.6 CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC 10.1021/acs.jmedchem.9b01835
CHEMBL4594959 176365 None 1 Human Binding pKi = 5.8 5.8 -114 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 448 11 1 3 5.6 CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC 10.1021/acs.jmedchem.9b01835
76314268 106490 None 0 Human Binding pKi = 4.8 4.8 -1230 4
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 450 3 1 4 3.5 Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2 10.1021/jm401384w
CHEMBL3115577 106490 None 0 Human Binding pKi = 4.8 4.8 -1230 4
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 450 3 1 4 3.5 Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2 10.1021/jm401384w
CHEMBL3139633 106490 None 0 Human Binding pKi = 4.8 4.8 -1230 4
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 450 3 1 4 3.5 Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2 10.1021/jm401384w
72164180 92179 None 0 Human Binding pKi = 5.8 5.8 -38 4
Binding affinity to human dopamine D5 receptor by radioligand binding assayBinding affinity to human dopamine D5 receptor by radioligand binding assay
ChEMBL 326 3 0 3 4.4 Clc1cccc(N2CCN(Cc3cccs3)CC2)c1Cl 10.1016/j.bmcl.2013.07.033
CHEMBL2420772 92179 None 0 Human Binding pKi = 5.8 5.8 -38 4
Binding affinity to human dopamine D5 receptor by radioligand binding assayBinding affinity to human dopamine D5 receptor by radioligand binding assay
ChEMBL 326 3 0 3 4.4 Clc1cccc(N2CCN(Cc3cccs3)CC2)c1Cl 10.1016/j.bmcl.2013.07.033
11134444 90667 None 0 Human Binding pKi = 5.8 5.8 -17 7
Binding affinity to human D5RBinding affinity to human D5R
ChEMBL 467 6 0 5 3.5 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmcl.2021.128028
CHEMBL238916 90667 None 0 Human Binding pKi = 5.8 5.8 -17 7
Binding affinity to human D5RBinding affinity to human D5R
ChEMBL 467 6 0 5 3.5 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmcl.2021.128028
11134444 90667 None 0 Human Binding pKi = 5.8 5.8 -17 7
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 467 6 0 5 3.5 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2007.06.002
CHEMBL238916 90667 None 0 Human Binding pKi = 5.8 5.8 -17 7
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 467 6 0 5 3.5 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2007.06.002
57401819 70184 None 0 Human Binding pKi = 5.8 5.8 -229 7
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 346 6 0 2 4.6 Fc1ccc(CCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 10.1016/j.bmc.2014.04.026
CHEMBL1940408 70184 None 0 Human Binding pKi = 5.8 5.8 -229 7
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 346 6 0 2 4.6 Fc1ccc(CCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 10.1016/j.bmc.2014.04.026
76314268 106490 None 0 Human Binding pKi = 4.8 4.8 -1230 4
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 450 3 1 4 3.5 Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2 10.1021/jm401384w
CHEMBL3115577 106490 None 0 Human Binding pKi = 4.8 4.8 -1230 4
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 450 3 1 4 3.5 Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2 10.1021/jm401384w
CHEMBL3139633 106490 None 0 Human Binding pKi = 4.8 4.8 -1230 4
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 450 3 1 4 3.5 Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2 10.1021/jm401384w
46227325 202583 None 0 Human Binding pKi = 5.7 5.7 1 2
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 267 0 1 2 3.4 CN1CCCc2cc(O)ccc2Cc2ccccc2C1 10.1016/j.bmc.2009.08.028
CHEMBL596179 202583 None 0 Human Binding pKi = 5.7 5.7 1 2
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 267 0 1 2 3.4 CN1CCCc2cc(O)ccc2Cc2ccccc2C1 10.1016/j.bmc.2009.08.028
11358377 204796 None 0 Human Binding pKi = 5.7 5.7 2 2
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 295 0 0 3 3.5 CN1CCCc2cc3c(cc2-c2ccccc2CC1)OCO3 10.1016/j.bmc.2009.08.028
CHEMBL610449 204796 None 0 Human Binding pKi = 5.7 5.7 2 2
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 295 0 0 3 3.5 CN1CCCc2cc3c(cc2-c2ccccc2CC1)OCO3 10.1016/j.bmc.2009.08.028
129989 451 None 33 Human Binding pKi = 5.7 5.7 -457 11
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 463 9 1 5 4.5 CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC 10.6019/CHEMBL5442175
8584 451 None 33 Human Binding pKi = 5.7 5.7 -457 11
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 463 9 1 5 4.5 CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC 10.6019/CHEMBL5442175
CHEMBL43383 451 None 33 Human Binding pKi = 5.7 5.7 -457 11
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 463 9 1 5 4.5 CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC 10.6019/CHEMBL5442175
154726793 176338 None 1 Human Binding pKi = 5.7 5.7 -61 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 454 11 0 6 5.2 CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC 10.1021/acs.jmedchem.9b01835
CHEMBL4590966 176338 None 1 Human Binding pKi = 5.7 5.7 -61 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 454 11 0 6 5.2 CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC 10.1021/acs.jmedchem.9b01835
CHEMBL4594692 176338 None 1 Human Binding pKi = 5.7 5.7 -61 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 454 11 0 6 5.2 CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC 10.1021/acs.jmedchem.9b01835
46227317 202619 None 0 Human Binding pKi = 6.7 6.7 -1 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 265 1 0 2 3.4 COc1ccc2c(c1)CCN1Cc3ccccc3CC21 10.1016/j.bmc.2009.08.028
CHEMBL596448 202619 None 0 Human Binding pKi = 6.7 6.7 -1 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 265 1 0 2 3.4 COc1ccc2c(c1)CCN1Cc3ccccc3CC21 10.1016/j.bmc.2009.08.028
44436306 97253 None 0 Human Binding pKi = 6.7 6.7 1 3
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 417 6 0 3 4.2 O=C1Cc2ccccc2N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2007.06.002
CHEMBL268371 97253 None 0 Human Binding pKi = 6.7 6.7 1 3
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 417 6 0 3 4.2 O=C1Cc2ccccc2N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2007.06.002
137645830 157944 None 0 Human Binding pKi = 4.7 4.7 -478 6
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 424 7 1 8 2.8 Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2c1OCCO2 10.1021/acs.jmedchem.7b00363
CHEMBL4083727 157944 None 0 Human Binding pKi = 4.7 4.7 -478 6
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 424 7 1 8 2.8 Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2c1OCCO2 10.1021/acs.jmedchem.7b00363
11449266 13956 None 0 Human Binding pKi = 4.7 4.7 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 257 2 1 2 2.9 COc1cc2c(cc1F)C[C@@H](N)[C@@H]2c1ccccc1 10.1021/jm040889k
CHEMBL1196658 13956 None 0 Human Binding pKi = 4.7 4.7 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 257 2 1 2 2.9 COc1cc2c(cc1F)C[C@@H](N)[C@@H]2c1ccccc1 10.1021/jm040889k
CHEMBL557781 13956 None 0 Human Binding pKi = 4.7 4.7 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 257 2 1 2 2.9 COc1cc2c(cc1F)C[C@@H](N)[C@@H]2c1ccccc1 10.1021/jm040889k
11449669 13957 None 0 Human Binding pKi = 4.7 4.7 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 271 3 1 2 3.1 CN[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1196659 13957 None 0 Human Binding pKi = 4.7 4.7 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 271 3 1 2 3.1 CN[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL557782 13957 None 0 Human Binding pKi = 4.7 4.7 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 271 3 1 2 3.1 CN[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 10.1021/jm040889k
11210215 14008 None 0 Human Binding pKi = 4.7 4.7 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 311 5 0 2 4.0 C=CCN(C)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1197038 14008 None 0 Human Binding pKi = 4.7 4.7 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 311 5 0 2 4.0 C=CCN(C)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL559164 14008 None 0 Human Binding pKi = 4.7 4.7 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 311 5 0 2 4.0 C=CCN(C)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 10.1021/jm040889k
76336022 106435 None 0 Human Binding pKi = 4.7 4.7 -512 3
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 386 6 1 5 3.3 Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2 10.1021/jm401384w
CHEMBL3115581 106435 None 0 Human Binding pKi = 4.7 4.7 -512 3
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 386 6 1 5 3.3 Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2 10.1021/jm401384w
CHEMBL3139316 106435 None 0 Human Binding pKi = 4.7 4.7 -512 3
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 386 6 1 5 3.3 Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2 10.1021/jm401384w
11775107 166311 None 0 Rat Binding pKi = 5.7 5.7 -588 3
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 443 7 1 4 4.5 COc1cccc2c1N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@@H]1CC2 10.1021/jm049031l
CHEMBL426629 166311 None 0 Rat Binding pKi = 5.7 5.7 -588 3
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 443 7 1 4 4.5 COc1cccc2c1N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@@H]1CC2 10.1021/jm049031l
76336022 106435 None 0 Human Binding pKi = 4.7 4.7 -512 3
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 386 6 1 5 3.3 Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2 10.1021/jm401384w
CHEMBL3115581 106435 None 0 Human Binding pKi = 4.7 4.7 -512 3
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 386 6 1 5 3.3 Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2 10.1021/jm401384w
CHEMBL3139316 106435 None 0 Human Binding pKi = 4.7 4.7 -512 3
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 386 6 1 5 3.3 Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2 10.1021/jm401384w
9893924 4750 None 24 Human Binding pKi = 5.7 5.7 -81 22
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 554 11 3 4 5.4 S=C(NCCCc1c[nH]cn1)NCCCN(Cc1ccc(Cl)c(Cl)c1)c1ccc(Br)cn1 10.6019/CHEMBL5442175
CHEMBL103769 4750 None 24 Human Binding pKi = 5.7 5.7 -81 22
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 554 11 3 4 5.4 S=C(NCCCc1c[nH]cn1)NCCCN(Cc1ccc(Cl)c(Cl)c1)c1ccc(Br)cn1 10.6019/CHEMBL5442175
135398737 958 None 57 Human Binding pKi = 6.7 6.7 -89 91
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2008.09.012
135398737.0 958 None 57 Human Binding pKi = 6.7 6.7 -89 91
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2008.09.012
38 958 None 57 Human Binding pKi = 6.7 6.7 -89 91
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2008.09.012
722 958 None 57 Human Binding pKi = 6.7 6.7 -89 91
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2008.09.012
CHEMBL42 958 None 57 Human Binding pKi = 6.7 6.7 -89 91
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2008.09.012
DB00363 958 None 57 Human Binding pKi = 6.7 6.7 -89 91
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2008.09.012
75306277 109310 None 0 Human Binding pKi = 6.7 6.7 -99 23
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 308 0 0 3 4.2 CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3 10.1039/C2MD00311B
CHEMBL3217984 109310 None 0 Human Binding pKi = 6.7 6.7 -99 23
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 308 0 0 3 4.2 CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3 10.1039/C2MD00311B
90644062 112097 None 0 Human Binding pKi = 5.7 5.7 -104 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 345 6 0 4 3.8 Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1 10.1016/j.bmc.2014.04.026
CHEMBL3289647 112097 None 0 Human Binding pKi = 5.7 5.7 -104 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 345 6 0 4 3.8 Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1 10.1016/j.bmc.2014.04.026
154727843 176538 None 1 Human Binding pKi = 5.7 5.7 -17 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 486 13 0 6 5.6 CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF 10.1021/acs.jmedchem.9b01835
CHEMBL4448853 176538 None 1 Human Binding pKi = 5.7 5.7 -17 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 486 13 0 6 5.6 CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF 10.1021/acs.jmedchem.9b01835
CHEMBL4596221 176538 None 1 Human Binding pKi = 5.7 5.7 -17 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 486 13 0 6 5.6 CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF 10.1021/acs.jmedchem.9b01835
107930 1529 None 25 Human Binding pKi = 8.7 8.7 -1 6
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 313 0 1 2 4.0 CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O 10.1016/j.bmcl.2009.12.100
107930.0 1529 None 25 Human Binding pKi = 8.7 8.7 -1 6
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 313 0 1 2 4.0 CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O 10.1016/j.bmcl.2009.12.100
3304 1529 None 25 Human Binding pKi = 8.7 8.7 -1 6
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 313 0 1 2 4.0 CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O 10.1016/j.bmcl.2009.12.100
CHEMBL298406 1529 None 25 Human Binding pKi = 8.7 8.7 -1 6
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 313 0 1 2 4.0 CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O 10.1016/j.bmcl.2009.12.100
DB12273 1529 None 25 Human Binding pKi = 8.7 8.7 -1 6
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 313 0 1 2 4.0 CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O 10.1016/j.bmcl.2009.12.100
107930 1529 None 25 Human Binding pKi = 8.7 8.7 -1 6
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 313 0 1 2 4.0 CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O 10.1016/j.bmcl.2009.12.094
107930.0 1529 None 25 Human Binding pKi = 8.7 8.7 -1 6
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 313 0 1 2 4.0 CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O 10.1016/j.bmcl.2009.12.094
3304 1529 None 25 Human Binding pKi = 8.7 8.7 -1 6
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 313 0 1 2 4.0 CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O 10.1016/j.bmcl.2009.12.094
CHEMBL298406 1529 None 25 Human Binding pKi = 8.7 8.7 -1 6
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 313 0 1 2 4.0 CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O 10.1016/j.bmcl.2009.12.094
DB12273 1529 None 25 Human Binding pKi = 8.7 8.7 -1 6
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 313 0 1 2 4.0 CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O 10.1016/j.bmcl.2009.12.094
46231927 203993 None 0 Human Binding pKi = 8.7 8.7 -2 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 432 3 1 4 5.4 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/Oc4ccccc4)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
CHEMBL605354 203993 None 0 Human Binding pKi = 8.7 8.7 -2 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 432 3 1 4 5.4 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/Oc4ccccc4)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
1243 3618 None 30 Human Binding pKi = 8.6 8.6 -2 15
Binding affinity to human D5 receptorBinding affinity to human D5 receptor
ChEMBL 331 1 1 2 3.8 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O 10.1016/j.bmcl.2020.127053
944 3618 None 30 Human Binding pKi = 8.6 8.6 -2 15
Binding affinity to human D5 receptorBinding affinity to human D5 receptor
ChEMBL 331 1 1 2 3.8 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O 10.1016/j.bmcl.2020.127053
CHEMBL324017 3618 None 30 Human Binding pKi = 8.6 8.6 -2 15
Binding affinity to human D5 receptorBinding affinity to human D5 receptor
ChEMBL 331 1 1 2 3.8 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O 10.1016/j.bmcl.2020.127053
45379369 7524 None 0 Human Binding pKi = 8.6 8.6 1 5
Displacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation counting
ChEMBL 290 0 1 1 3.8 CN1CCc2ccccc2Cc2c[nH]c3cccc(c23)CC1 10.1021/jm901291r
CHEMBL1087300 7524 None 0 Human Binding pKi = 8.6 8.6 1 5
Displacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation counting
ChEMBL 290 0 1 1 3.8 CN1CCc2ccccc2Cc2c[nH]c3cccc(c23)CC1 10.1021/jm901291r
46231926 203035 None 0 Human Binding pKi = 8.6 8.6 -12 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 446 4 1 4 5.5 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/OCc4ccccc4)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
CHEMBL599135 203035 None 0 Human Binding pKi = 8.6 8.6 -12 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 446 4 1 4 5.5 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/OCc4ccccc4)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
3036864 205211 None 16 Human Binding pKi = 8.6 8.6 -3 27
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2009.12.100
CHEMBL1256645 205211 None 16 Human Binding pKi = 8.6 8.6 -3 27
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2009.12.100
CHEMBL1814790 205211 None 16 Human Binding pKi = 8.6 8.6 -3 27
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2009.12.100
CHEMBL62 205211 None 16 Human Binding pKi = 8.6 8.6 -3 27
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2009.12.100
11416809 12808 None 0 Human Binding pKi = 4.7 4.7 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 313 5 0 2 4.2 CCCN(C)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1188198 12808 None 0 Human Binding pKi = 4.7 4.7 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 313 5 0 2 4.2 CCCN(C)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL535602 12808 None 0 Human Binding pKi = 4.7 4.7 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 313 5 0 2 4.2 CCCN(C)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 10.1021/jm040889k
23653176 91237 None 0 Human Binding pKi = 6.7 6.7 4 3
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 383 6 0 3 3.8 O=C1Cc2ccccc2N1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2007.06.002
CHEMBL239917 91237 None 0 Human Binding pKi = 6.7 6.7 4 3
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 383 6 0 3 3.8 O=C1Cc2ccccc2N1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2007.06.002
763625 92182 None 4 Human Binding pKi = 5.7 5.7 -19 2
Binding affinity to human dopamine D5 receptor by radioligand binding assayBinding affinity to human dopamine D5 receptor by radioligand binding assay
ChEMBL 276 3 0 3 3.2 Fc1ccc(N2CCN(Cc3cccs3)CC2)cc1 10.1016/j.bmcl.2013.07.033
CHEMBL2420775 92182 None 4 Human Binding pKi = 5.7 5.7 -19 2
Binding affinity to human dopamine D5 receptor by radioligand binding assayBinding affinity to human dopamine D5 receptor by radioligand binding assay
ChEMBL 276 3 0 3 3.2 Fc1ccc(N2CCN(Cc3cccs3)CC2)cc1 10.1016/j.bmcl.2013.07.033
3038495 708 None 33 Human Binding pKi = 5.7 5.7 -1047 27
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 417 8 1 4 4.2 COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 10.6019/CHEMBL5442175
7625 708 None 33 Human Binding pKi = 5.7 5.7 -1047 27
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 417 8 1 4 4.2 COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 10.6019/CHEMBL5442175
CHEMBL25236 708 None 33 Human Binding pKi = 5.7 5.7 -1047 27
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 417 8 1 4 4.2 COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 10.6019/CHEMBL5442175
1212 1662 None 37 Human Binding pKi = 7.7 7.7 -28 65
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1016/j.bmcl.2008.09.012
204 1662 None 37 Human Binding pKi = 7.7 7.7 -28 65
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1016/j.bmcl.2008.09.012
3372 1662 None 37 Human Binding pKi = 7.7 7.7 -28 65
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1016/j.bmcl.2008.09.012
3372.0 1662 None 37 Human Binding pKi = 7.7 7.7 -28 65
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1016/j.bmcl.2008.09.012
CHEMBL726 1662 None 37 Human Binding pKi = 7.7 7.7 -28 65
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1016/j.bmcl.2008.09.012
DB00623 1662 None 37 Human Binding pKi = 7.7 7.7 -28 65
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1016/j.bmcl.2008.09.012
164615845 185296 None 0 Human Binding pKi = 5.7 5.7 -2 6
Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)
ChEMBL 389 2 1 4 3.7 O=C(O)c1ccc(C#Cc2ccc3c(c2)C=C([N+](=O)[O-])C(C(F)(F)F)O3)cc1 10.1016/j.bmcl.2021.128008
CHEMBL4857492 185296 None 0 Human Binding pKi = 5.7 5.7 -2 6
Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)
ChEMBL 389 2 1 4 3.7 O=C(O)c1ccc(C#Cc2ccc3c(c2)C=C([N+](=O)[O-])C(C(F)(F)F)O3)cc1 10.1016/j.bmcl.2021.128008
164623060 186276 None 0 Human Binding pKi = 5.7 5.7 - 1
Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)
ChEMBL 325 1 0 3 4.0 CC(C)(C)C#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 10.1016/j.bmcl.2021.128008
CHEMBL4872572 186276 None 0 Human Binding pKi = 5.7 5.7 - 1
Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)
ChEMBL 325 1 0 3 4.0 CC(C)(C)C#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 10.1016/j.bmcl.2021.128008
122177644 121276 None 0 Human Binding pKi = 4.7 4.7 -17378 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis
ChEMBL 591 18 2 8 5.6 CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@@H]3CCc4c(O)cccc4C3)cc2OC)nn1 10.1021/jm501889t
CHEMBL3577345 121276 None 0 Human Binding pKi = 4.7 4.7 -17378 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis
ChEMBL 591 18 2 8 5.6 CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@@H]3CCc4c(O)cccc4C3)cc2OC)nn1 10.1021/jm501889t
154725234 176397 None 1 Human Binding pKi = 5.7 5.7 -3 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 472 12 0 6 5.2 CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF 10.1021/acs.jmedchem.9b01835
CHEMBL4585289 176397 None 1 Human Binding pKi = 5.7 5.7 -3 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 472 12 0 6 5.2 CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF 10.1021/acs.jmedchem.9b01835
CHEMBL4595149 176397 None 1 Human Binding pKi = 5.7 5.7 -3 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 472 12 0 6 5.2 CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF 10.1021/acs.jmedchem.9b01835
90644062 112097 None 0 Human Binding pKi = 5.7 5.7 -104 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 345 6 0 4 3.8 Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1 10.1016/j.bmc.2014.04.026
CHEMBL3289647 112097 None 0 Human Binding pKi = 5.7 5.7 -104 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 345 6 0 4 3.8 Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1 10.1016/j.bmc.2014.04.026
46231924 203034 None 0 Human Binding pKi = 7.7 7.7 -5 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 370 2 1 4 4.0 CO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C 10.1016/j.bmcl.2009.12.094
CHEMBL599134 203034 None 0 Human Binding pKi = 7.7 7.7 -5 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 370 2 1 4 4.0 CO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C 10.1016/j.bmcl.2009.12.094
154705128 176396 None 1 Human Binding pKi = 5.7 5.7 -151 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 462 12 1 3 6.0 CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC 10.1021/acs.jmedchem.9b01835
CHEMBL4454872 176396 None 1 Human Binding pKi = 5.7 5.7 -151 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 462 12 1 3 6.0 CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC 10.1021/acs.jmedchem.9b01835
CHEMBL4595148 176396 None 1 Human Binding pKi = 5.7 5.7 -151 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 462 12 1 3 6.0 CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC 10.1021/acs.jmedchem.9b01835
156020558 178151 None 0 Human Binding pKi = 6.7 6.7 -3 2
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 347 1 2 3 3.5 CN1CCc2cc(O)c(O)cc2C(c2ccccc2Br)C1 10.1016/j.bmcl.2020.127305
CHEMBL4647167 178151 None 0 Human Binding pKi = 6.7 6.7 -3 2
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 347 1 2 3 3.5 CN1CCc2cc(O)c(O)cc2C(c2ccccc2Br)C1 10.1016/j.bmcl.2020.127305
11558247 75449 None 0 Human Binding pKi = 6.6 6.6 -6 3
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 282 0 2 3 2.6 CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1 10.1021/jm051237e
CHEMBL204098 75449 None 0 Human Binding pKi = 6.6 6.6 -6 3
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 282 0 2 3 2.6 CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1 10.1021/jm051237e
145969667 165060 None 0 Human Binding pKi = 6.6 6.6 -41 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 289 9 1 2 4.9 CCCCCCCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
CHEMBL4225278 165060 None 0 Human Binding pKi = 6.6 6.6 -41 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 289 9 1 2 4.9 CCCCCCCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
44436301 90666 None 0 Human Binding pKi = 6.6 6.6 -6 4
Binding affinity to human D5RBinding affinity to human D5R
ChEMBL 433 6 0 5 3.1 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2021.128028
CHEMBL238915 90666 None 0 Human Binding pKi = 6.6 6.6 -6 4
Binding affinity to human D5RBinding affinity to human D5R
ChEMBL 433 6 0 5 3.1 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2021.128028
44436301 90666 None 0 Human Binding pKi = 6.6 6.6 -6 4
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 433 6 0 5 3.1 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2007.06.002
CHEMBL238915 90666 None 0 Human Binding pKi = 6.6 6.6 -6 4
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 433 6 0 5 3.1 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2007.06.002
135398737 958 None 57 Human Binding pKi = 6.6 6.6 -89 91
Displacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C5MD00258C
135398737.0 958 None 57 Human Binding pKi = 6.6 6.6 -89 91
Displacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C5MD00258C
38 958 None 57 Human Binding pKi = 6.6 6.6 -89 91
Displacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C5MD00258C
722 958 None 57 Human Binding pKi = 6.6 6.6 -89 91
Displacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C5MD00258C
CHEMBL42 958 None 57 Human Binding pKi = 6.6 6.6 -89 91
Displacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C5MD00258C
DB00363 958 None 57 Human Binding pKi = 6.6 6.6 -89 91
Displacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C5MD00258C
44209472 70196 None 1 Human Binding pKi = 5.6 5.6 -1318 11
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 315 6 0 4 2.8 Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmc.2014.04.026
CHEMBL1940420 70196 None 1 Human Binding pKi = 5.6 5.6 -1318 11
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 315 6 0 4 2.8 Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmc.2014.04.026
181743 178677 None 4 Human Binding pKi = 5.6 5.6 -1202 22
Displacement of [3H]SCH233930 from human dopamine D5 receptorDisplacement of [3H]SCH233930 from human dopamine D5 receptor
ChEMBL 339 2 0 5 3.2 COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4 10.1016/j.bmcl.2009.11.053
CHEMBL467094 178677 None 4 Human Binding pKi = 5.6 5.6 -1202 22
Displacement of [3H]SCH233930 from human dopamine D5 receptorDisplacement of [3H]SCH233930 from human dopamine D5 receptor
ChEMBL 339 2 0 5 3.2 COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4 10.1016/j.bmcl.2009.11.053
122177641 121273 None 0 Human Binding pKi = 4.6 4.6 -38018 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis
ChEMBL 551 18 1 8 4.6 C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1 10.1021/jm501889t
CHEMBL3577342 121273 None 0 Human Binding pKi = 4.6 4.6 -38018 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis
ChEMBL 551 18 1 8 4.6 C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1 10.1021/jm501889t
161665 172688 None 26 Human Binding pKi = 6.6 6.6 -3 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hr
ChEMBL 341 3 1 5 3.1 COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2 10.1016/j.bmcl.2017.01.090
CHEMBL448891 172688 None 26 Human Binding pKi = 6.6 6.6 -3 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hr
ChEMBL 341 3 1 5 3.1 COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2 10.1016/j.bmcl.2017.01.090
681 1465 None 47 Human Binding pKi = 5.6 5.6 -67 38
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm040889k
681.0 1465 None 47 Human Binding pKi = 5.6 5.6 -67 38
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm040889k
940 1465 None 47 Human Binding pKi = 5.6 5.6 -67 38
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm040889k
947 1465 None 47 Human Binding pKi = 5.6 5.6 -67 38
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm040889k
CHEMBL59 1465 None 47 Human Binding pKi = 5.6 5.6 -67 38
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm040889k
DB00988 1465 None 47 Human Binding pKi = 5.6 5.6 -67 38
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm040889k
6852376 91633 None 9 Human Binding pKi = 6.6 6.6 3 5
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 255 1 3 3 2.4 Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 10.1016/j.bmcl.2013.12.024
CHEMBL1467585 91633 None 9 Human Binding pKi = 6.6 6.6 3 5
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 255 1 3 3 2.4 Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 10.1016/j.bmcl.2013.12.024
CHEMBL24077 91633 None 9 Human Binding pKi = 6.6 6.6 3 5
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 255 1 3 3 2.4 Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 10.1016/j.bmcl.2013.12.024
CHEMBL503958 91633 None 9 Human Binding pKi = 6.6 6.6 3 5
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 255 1 3 3 2.4 Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 10.1016/j.bmcl.2013.12.024
76325152 106427 None 0 Human Binding pKi = 5.6 5.6 -251 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 359 9 2 4 4.0 Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2 10.1021/jm401384w
CHEMBL3115579 106427 None 0 Human Binding pKi = 5.6 5.6 -251 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 359 9 2 4 4.0 Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2 10.1021/jm401384w
CHEMBL3139262 106427 None 0 Human Binding pKi = 5.6 5.6 -251 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 359 9 2 4 4.0 Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2 10.1021/jm401384w
6852376 91633 None 9 Human Binding pKi = 6.6 6.6 3 5
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 255 1 3 3 2.4 Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 10.1016/j.bmcl.2013.12.024
CHEMBL1467585 91633 None 9 Human Binding pKi = 6.6 6.6 3 5
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 255 1 3 3 2.4 Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 10.1016/j.bmcl.2013.12.024
CHEMBL24077 91633 None 9 Human Binding pKi = 6.6 6.6 3 5
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 255 1 3 3 2.4 Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 10.1016/j.bmcl.2013.12.024
CHEMBL503958 91633 None 9 Human Binding pKi = 6.6 6.6 3 5
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 255 1 3 3 2.4 Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 10.1016/j.bmcl.2013.12.024
156015018 177676 None 0 Human Binding pKi = 7.6 7.6 2 2
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 337 2 2 3 4.0 COc1cc2c(cc1O)C(c1c(Cl)cccc1Cl)CNCC2 10.1016/j.bmcl.2020.127305
CHEMBL4640497 177676 None 0 Human Binding pKi = 7.6 7.6 2 2
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 337 2 2 3 4.0 COc1cc2c(cc1O)C(c1c(Cl)cccc1Cl)CNCC2 10.1016/j.bmcl.2020.127305
122177643 121275 None 0 Human Binding pKi = 4.6 4.6 -15848 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis
ChEMBL 632 20 3 9 5.1 CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)CCc3ccc(O)c4[nH]c(=O)ccc34)cc2OC)nn1 10.1021/jm501889t
CHEMBL3577344 121275 None 0 Human Binding pKi = 4.6 4.6 -15848 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis
ChEMBL 632 20 3 9 5.1 CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)CCc3ccc(O)c4[nH]c(=O)ccc34)cc2OC)nn1 10.1021/jm501889t
90644061 112096 None 0 Human Binding pKi = 5.6 5.6 -2344 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 329 6 0 4 3.1 Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1 10.1016/j.bmc.2014.04.026
CHEMBL3289646 112096 None 0 Human Binding pKi = 5.6 5.6 -2344 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 329 6 0 4 3.1 Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1 10.1016/j.bmc.2014.04.026
11610526 2282 None 43 Human Binding pKi = 6.6 6.6 -74 7
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F 10.6019/CHEMBL5442175
11610526.0 2282 None 43 Human Binding pKi = 6.6 6.6 -74 7
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F 10.6019/CHEMBL5442175
3928 2282 None 43 Human Binding pKi = 6.6 6.6 -74 7
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F 10.6019/CHEMBL5442175
5351 2282 None 43 Human Binding pKi = 6.6 6.6 -74 7
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F 10.6019/CHEMBL5442175
CHEMBL3039520 2282 None 43 Human Binding pKi = 6.6 6.6 -74 7
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F 10.6019/CHEMBL5442175
DB11732 2282 None 43 Human Binding pKi = 6.6 6.6 -74 7
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 377 4 1 4 3.3 CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F 10.6019/CHEMBL5442175
90644061 112096 None 0 Human Binding pKi = 5.6 5.6 -2344 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 329 6 0 4 3.1 Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1 10.1016/j.bmc.2014.04.026
CHEMBL3289646 112096 None 0 Human Binding pKi = 5.6 5.6 -2344 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 329 6 0 4 3.1 Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1 10.1016/j.bmc.2014.04.026
11223708 166404 None 0 Rat Binding pKi = 6.6 6.6 -16 3
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 413 6 1 3 4.5 O=C(NCCCCN1CCN2c3ccccc3CC[C@H]2C1)c1ccc2ccccc2c1 10.1021/jm049031l
CHEMBL427173 166404 None 0 Rat Binding pKi = 6.6 6.6 -16 3
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 413 6 1 3 4.5 O=C(NCCCCN1CCN2c3ccccc3CC[C@H]2C1)c1ccc2ccccc2c1 10.1021/jm049031l
46231848 202994 None 0 Human Binding pKi = 7.6 7.6 -8 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 396 1 1 3 4.1 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(N4CCCC4=O)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
CHEMBL598949 202994 None 0 Human Binding pKi = 7.6 7.6 -8 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 396 1 1 3 4.1 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(N4CCCC4=O)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
1353 1911 None 63 Human Binding pKi = 6.6 6.6 -54 85
Compound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm9601720
3559 1911 None 63 Human Binding pKi = 6.6 6.6 -54 85
Compound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm9601720
3559.0 1911 None 63 Human Binding pKi = 6.6 6.6 -54 85
Compound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm9601720
86 1911 None 63 Human Binding pKi = 6.6 6.6 -54 85
Compound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm9601720
CHEMBL54 1911 None 63 Human Binding pKi = 6.6 6.6 -54 85
Compound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm9601720
DB00502 1911 None 63 Human Binding pKi = 6.6 6.6 -54 85
Compound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm9601720
11246806 13012 None 0 Human Binding pKi = 4.6 4.6 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 327 6 1 2 4.7 CCCN(CCC)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1189734 13012 None 0 Human Binding pKi = 4.6 4.6 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 327 6 1 2 4.7 CCCN(CCC)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL539334 13012 None 0 Human Binding pKi = 4.6 4.6 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 327 6 1 2 4.7 CCCN(CCC)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
11522476 74549 None 0 Human Binding pKi = 5.6 5.6 -5 3
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 311 2 0 3 3.3 COc1cc2c(cc1OC)Cc1ccccc1CCN(C)CC2 10.1021/jm050846j
CHEMBL202924 74549 None 0 Human Binding pKi = 5.6 5.6 -5 3
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 311 2 0 3 3.3 COc1cc2c(cc1OC)Cc1ccccc1CCN(C)CC2 10.1021/jm050846j
156017805 177931 None 0 Human Binding pKi = 6.6 6.6 -5 2
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 343 4 1 3 4.2 C=CCN1CCc2cc(OC)c(O)cc2C(c2ccccc2Cl)C1 10.1016/j.bmcl.2020.127305
CHEMBL4643886 177931 None 0 Human Binding pKi = 6.6 6.6 -5 2
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 343 4 1 3 4.2 C=CCN1CCc2cc(OC)c(O)cc2C(c2ccccc2Cl)C1 10.1016/j.bmcl.2020.127305
25212275 174525 None 0 Human Binding pKi = 6.6 6.6 -6309 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 682 13 0 8 7.4 O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1 10.1016/j.bmcl.2008.09.012
CHEMBL455288 174525 None 0 Human Binding pKi = 6.6 6.6 -6309 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 682 13 0 8 7.4 O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1 10.1016/j.bmcl.2008.09.012
25212276 190175 None 0 Human Binding pKi = 6.6 6.6 -741 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 508 11 0 3 7.4 CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1 10.1016/j.bmcl.2008.09.012
CHEMBL517244 190175 None 0 Human Binding pKi = 6.6 6.6 -741 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 508 11 0 3 7.4 CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1 10.1016/j.bmcl.2008.09.012
1530 2182 None 36 Human Binding pKi = 5.6 5.6 -2691 24
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 10.6019/CHEMBL5442175
3827 2182 None 36 Human Binding pKi = 5.6 5.6 -2691 24
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 10.6019/CHEMBL5442175
3827.0 2182 None 36 Human Binding pKi = 5.6 5.6 -2691 24
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 10.6019/CHEMBL5442175
7206 2182 None 36 Human Binding pKi = 5.6 5.6 -2691 24
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 10.6019/CHEMBL5442175
CHEMBL534 2182 None 36 Human Binding pKi = 5.6 5.6 -2691 24
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 10.6019/CHEMBL5442175
DB00920 2182 None 36 Human Binding pKi = 5.6 5.6 -2691 24
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 10.6019/CHEMBL5442175
57391307 70187 None 0 Human Binding pKi = 5.6 5.6 -389 7
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 348 6 0 3 4.1 Fc1ccc(OCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 10.1016/j.bmc.2014.04.026
CHEMBL1940411 70187 None 0 Human Binding pKi = 5.6 5.6 -389 7
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 348 6 0 3 4.1 Fc1ccc(OCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 10.1016/j.bmc.2014.04.026
146025727 171788 None 0 Human Binding pKi = 7.6 7.6 4 27
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method
ChEMBL 411 3 0 5 6.4 FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12 10.1021/acs.jmedchem.9b00351
CHEMBL4466483 171788 None 0 Human Binding pKi = 7.6 7.6 4 27
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method
ChEMBL 411 3 0 5 6.4 FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12 10.1021/acs.jmedchem.9b00351
11316709 168473 None 0 Rat Binding pKi = 5.6 5.6 -323 3
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 443 7 1 4 4.5 COc1cccc2c1CC[C@@H]1CN(CCCCNC(=O)c3ccc4ccccc4c3)CCN21 10.1021/jm049031l
CHEMBL434532 168473 None 0 Rat Binding pKi = 5.6 5.6 -323 3
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 443 7 1 4 4.5 COc1cccc2c1CC[C@@H]1CN(CCCCNC(=O)c3ccc4ccccc4c3)CCN21 10.1021/jm049031l
44591099 176294 None 0 Human Binding pKi = 6.6 6.6 -1023 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 494 10 0 3 7.0 CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1 10.1016/j.bmcl.2008.09.012
CHEMBL459350 176294 None 0 Human Binding pKi = 6.6 6.6 -1023 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 494 10 0 3 7.0 CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1 10.1016/j.bmcl.2008.09.012
76325156 106446 None 0 Human Binding pKi = 5.6 5.6 -12302 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 263 7 2 3 3.3 CCCCCCNC[C@H]1CCc2ccc(O)cc2O1 10.1021/jm401384w
CHEMBL3115585 106446 None 0 Human Binding pKi = 5.6 5.6 -12302 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 263 7 2 3 3.3 CCCCCCNC[C@H]1CCc2ccc(O)cc2O1 10.1021/jm401384w
CHEMBL3139393 106446 None 0 Human Binding pKi = 5.6 5.6 -12302 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 263 7 2 3 3.3 CCCCCCNC[C@H]1CCc2ccc(O)cc2O1 10.1021/jm401384w
76325156 106446 None 0 Human Binding pKi = 4.6 4.6 -12302 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 263 7 2 3 3.3 CCCCCCNC[C@H]1CCc2ccc(O)cc2O1 10.1021/jm401384w
CHEMBL3115585 106446 None 0 Human Binding pKi = 4.6 4.6 -12302 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 263 7 2 3 3.3 CCCCCCNC[C@H]1CCc2ccc(O)cc2O1 10.1021/jm401384w
CHEMBL3139393 106446 None 0 Human Binding pKi = 4.6 4.6 -12302 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 263 7 2 3 3.3 CCCCCCNC[C@H]1CCc2ccc(O)cc2O1 10.1021/jm401384w
164606105 194146 None 0 Human Binding pKi = 5.6 5.6 -3 2
Binding affinity to dopamine 5 receptor (unknown origin)Binding affinity to dopamine 5 receptor (unknown origin)
ChEMBL 279 1 0 3 3.3 O=[N+]([O-])C1=Cc2cc(Cl)ccc2OC1C(F)(F)F 10.1016/j.bmcl.2022.128981
CHEMBL5279730 194146 None 0 Human Binding pKi = 5.6 5.6 -3 2
Binding affinity to dopamine 5 receptor (unknown origin)Binding affinity to dopamine 5 receptor (unknown origin)
ChEMBL 279 1 0 3 3.3 O=[N+]([O-])C1=Cc2cc(Cl)ccc2OC1C(F)(F)F 10.1016/j.bmcl.2022.128981
46869265 16264 None 0 Human Binding pKi = 5.6 5.6 -13 7
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 295 1 3 3 3.1 Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21 10.1016/j.bmc.2010.07.052
CHEMBL1224527 16264 None 0 Human Binding pKi = 5.6 5.6 -13 7
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 295 1 3 3 3.1 Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21 10.1016/j.bmc.2010.07.052
122181326 121933 None 0 Human Binding pKi = 5.6 5.6 -933 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranes
ChEMBL 413 8 1 5 4.2 COc1ccccc1N1CCN(CCCCNC(=O)/N=N/c2ccc(F)cc2)CC1 10.1016/j.bmc.2014.12.012
CHEMBL3590077 121933 None 0 Human Binding pKi = 5.6 5.6 -933 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranes
ChEMBL 413 8 1 5 4.2 COc1ccccc1N1CCN(CCCCNC(=O)/N=N/c2ccc(F)cc2)CC1 10.1016/j.bmc.2014.12.012
57401820 70185 None 0 Human Binding pKi = 5.6 5.6 -323 7
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 364 6 0 3 4.8 Fc1ccc(SCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 10.1016/j.bmc.2014.04.026
CHEMBL1940409 70185 None 0 Human Binding pKi = 5.6 5.6 -323 7
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 364 6 0 3 4.8 Fc1ccc(SCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 10.1016/j.bmc.2014.04.026
42611190 3156 None 14 Human Binding pKi = 5.6 5.6 -4265 22
GPCRScan assay: inhibition of D5GPCRScan assay: inhibition of D5
ChEMBL 475 4 2 2 7.4 OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F 10.6019/CHEMBL4507292
5802 3156 None 14 Human Binding pKi = 5.6 5.6 -4265 22
GPCRScan assay: inhibition of D5GPCRScan assay: inhibition of D5
ChEMBL 475 4 2 2 7.4 OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F 10.6019/CHEMBL4507292
CHEMBL1800685 3156 None 14 Human Binding pKi = 5.6 5.6 -4265 22
GPCRScan assay: inhibition of D5GPCRScan assay: inhibition of D5
ChEMBL 475 4 2 2 7.4 OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F 10.6019/CHEMBL4507292
42611190 3156 None 14 Human Binding pKi = 5.6 5.6 -4265 22
GPCRScan assay: inhibition of D5GPCRScan assay: inhibition of D5
ChEMBL 475 4 2 2 7.4 OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F 10.6019/CHEMBL4507292
5802 3156 None 14 Human Binding pKi = 5.6 5.6 -4265 22
GPCRScan assay: inhibition of D5GPCRScan assay: inhibition of D5
ChEMBL 475 4 2 2 7.4 OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F 10.6019/CHEMBL4507292
CHEMBL1800685 3156 None 14 Human Binding pKi = 5.6 5.6 -4265 22
GPCRScan assay: inhibition of D5GPCRScan assay: inhibition of D5
ChEMBL 475 4 2 2 7.4 OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F 10.6019/CHEMBL4507292
147326216 196748 None 0 Human Binding pKi = 5.6 5.6 -28 15
Binding affinity to dopamine D5 receptor (unknown origin) assessed as inhibition constantBinding affinity to dopamine D5 receptor (unknown origin) assessed as inhibition constant
ChEMBL 424 10 2 6 4.3 CCN(CC)CCCC(C)Nc1cnc(C(=O)Nc2cc(F)cc3cccnc23)cn1 10.1021/acs.jmedchem.2c01769
CHEMBL5431371 196748 None 0 Human Binding pKi = 5.6 5.6 -28 15
Binding affinity to dopamine D5 receptor (unknown origin) assessed as inhibition constantBinding affinity to dopamine D5 receptor (unknown origin) assessed as inhibition constant
ChEMBL 424 10 2 6 4.3 CCN(CC)CCCC(C)Nc1cnc(C(=O)Nc2cc(F)cc3cccnc23)cn1 10.1021/acs.jmedchem.2c01769
CHEMBL4566600 216486 None 0 Human Binding pKi = 5.5 5.5 -1 6
GPCRScan assay: inhibition of D5GPCRScan assay: inhibition of D5
ChEMBL None None None Cc1c(C(=O)O)cc(-c2ccc(C3CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc12 10.6019/CHEMBL4507292
CHEMBL4745071 216486 None 0 Human Binding pKi = 5.5 5.5 -1 6
GPCRScan assay: inhibition of D5GPCRScan assay: inhibition of D5
ChEMBL None None None Cc1c(C(=O)O)cc(-c2ccc(C3CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc12 10.6019/CHEMBL4507292
CHEMBL4566600 216486 None 0 Human Binding pKi = 5.5 5.5 -1 6
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000337aCl DRD5Selectivity interaction (GPCR panel (PDSP screen)) EUB0000337aCl DRD5
ChEMBL None None None Cc1c(C(=O)O)cc(-c2ccc(C3CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc12 10.6019/CHEMBL5212743
CHEMBL4745071 216486 None 0 Human Binding pKi = 5.5 5.5 -1 6
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000337aCl DRD5Selectivity interaction (GPCR panel (PDSP screen)) EUB0000337aCl DRD5
ChEMBL None None None Cc1c(C(=O)O)cc(-c2ccc(C3CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc12 10.6019/CHEMBL5212743
145967572 165028 None 0 Human Binding pKi = 6.5 6.5 -56 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 275 8 1 2 4.5 CCCCCCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
CHEMBL4224763 165028 None 0 Human Binding pKi = 6.5 6.5 -56 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 275 8 1 2 4.5 CCCCCCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
CHEMBL4566600 216486 None 0 Human Binding pKi = 5.5 5.5 -1 6
GPCRScan assay: inhibition of D5GPCRScan assay: inhibition of D5
ChEMBL None None None Cc1c(C(=O)O)cc(-c2ccc(C3CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc12 10.6019/CHEMBL4507292
CHEMBL4745071 216486 None 0 Human Binding pKi = 5.5 5.5 -1 6
GPCRScan assay: inhibition of D5GPCRScan assay: inhibition of D5
ChEMBL None None None Cc1c(C(=O)O)cc(-c2ccc(C3CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc12 10.6019/CHEMBL4507292
76325152 106427 None 0 Human Binding pKi = 5.5 5.5 -251 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 359 9 2 4 4.0 Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2 10.1021/jm401384w
CHEMBL3115579 106427 None 0 Human Binding pKi = 5.5 5.5 -251 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 359 9 2 4 4.0 Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2 10.1021/jm401384w
CHEMBL3139262 106427 None 0 Human Binding pKi = 5.5 5.5 -251 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 359 9 2 4 4.0 Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2 10.1021/jm401384w
122181329 121936 None 0 Human Binding pKi = 5.5 5.5 -9332 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranes
ChEMBL 394 10 1 2 4.6 CCCN(CCCCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1 10.1016/j.bmc.2014.12.012
CHEMBL3590080 121936 None 0 Human Binding pKi = 5.5 5.5 -9332 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranes
ChEMBL 394 10 1 2 4.6 CCCN(CCCCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1 10.1016/j.bmc.2014.12.012
10531 1420 None 13 Human Binding pKi = 5.5 5.5 -7762 30
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.6019/CHEMBL5442175
10531.0 1420 None 13 Human Binding pKi = 5.5 5.5 -7762 30
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.6019/CHEMBL5442175
121 1420 None 13 Human Binding pKi = 5.5 5.5 -7762 30
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.6019/CHEMBL5442175
888 1420 None 13 Human Binding pKi = 5.5 5.5 -7762 30
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.6019/CHEMBL5442175
CHEMBL1732 1420 None 13 Human Binding pKi = 5.5 5.5 -7762 30
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.6019/CHEMBL5442175
DB00320 1420 None 13 Human Binding pKi = 5.5 5.5 -7762 30
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.6019/CHEMBL5442175
44591135 190286 None 0 Human Binding pKi = 6.5 6.5 -190 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 532 10 0 4 8.0 CN(CC/C=C1\c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1 10.1016/j.bmcl.2008.09.012
CHEMBL517407 190286 None 0 Human Binding pKi = 6.5 6.5 -190 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 532 10 0 4 8.0 CN(CC/C=C1\c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1 10.1016/j.bmcl.2008.09.012
122205437 137398 None 0 Human Binding pKi = 8.5 8.5 7 5
Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay
ChEMBL 257 0 0 2 3.4 CN1CCc2ccccc2Cc2sccc2CC1 10.1039/C5MD00258C
CHEMBL3752512 137398 None 0 Human Binding pKi = 8.5 8.5 7 5
Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay
ChEMBL 257 0 0 2 3.4 CN1CCc2ccccc2Cc2sccc2CC1 10.1039/C5MD00258C
6603703 208 None 8 Human Binding pKi = 8.5 8.5 1 12
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 329 2 3 4 3.3 NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3 10.6019/CHEMBL5442175
9637 208 None 8 Human Binding pKi = 8.5 8.5 1 12
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 329 2 3 4 3.3 NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3 10.6019/CHEMBL5442175
CHEMBL291143 208 None 8 Human Binding pKi = 8.5 8.5 1 12
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 329 2 3 4 3.3 NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3 10.6019/CHEMBL5442175
11486421 203651 None 0 Human Binding pKi = 8.5 8.5 -2 3
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 400 2 2 4 4.5 CCOC(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C 10.1016/j.bmcl.2009.12.100
CHEMBL603485 203651 None 0 Human Binding pKi = 8.5 8.5 -2 3
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 400 2 2 4 4.5 CCOC(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C 10.1016/j.bmcl.2009.12.100
46231846 203796 None 0 Human Binding pKi = 8.5 8.5 -1 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 341 1 1 3 3.8 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C=O)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
CHEMBL604316 203796 None 0 Human Binding pKi = 8.5 8.5 -1 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 341 1 1 3 3.8 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C=O)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
46231849 203875 None 0 Human Binding pKi = 8.5 8.5 -2 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 356 1 2 4 3.8 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/O)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
CHEMBL604732 203875 None 0 Human Binding pKi = 8.5 8.5 -2 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 356 1 2 4 3.8 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/O)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
46231994 202864 None 0 Human Binding pKi = 8.5 8.5 -5 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 414 1 1 3 5.5 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc(C#N)c4)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
CHEMBL598105 202864 None 0 Human Binding pKi = 8.5 8.5 -5 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 414 1 1 3 5.5 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc(C#N)c4)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
44439942 151954 None 0 Human Binding pKi = 8.4 8.4 -4 4
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 320 1 1 2 3.8 COc1ccc2[nH]c3c(c2c1)CCN(C)CCc1ccccc1C3 10.1016/j.bmcl.2006.11.093
CHEMBL396560 151954 None 0 Human Binding pKi = 8.4 8.4 -4 4
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 320 1 1 2 3.8 COc1ccc2[nH]c3c(c2c1)CCN(C)CCc1ccccc1C3 10.1016/j.bmcl.2006.11.093
46231782 202959 None 0 Human Binding pKi = 8.4 8.4 -1 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 371 1 1 4 3.8 COC(=O)c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C 10.1016/j.bmcl.2009.12.094
CHEMBL598730 202959 None 0 Human Binding pKi = 8.4 8.4 -1 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 371 1 1 4 3.8 COC(=O)c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C 10.1016/j.bmcl.2009.12.094
46231541 202644 None 0 Human Binding pKi = 8.4 8.4 -4 3
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 370 4 2 3 4.3 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CNC3CCC3)cc2)C1 10.1016/j.bmcl.2009.12.100
CHEMBL596622 202644 None 0 Human Binding pKi = 8.4 8.4 -4 3
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 370 4 2 3 4.3 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CNC3CCC3)cc2)C1 10.1016/j.bmcl.2009.12.100
1243 3618 None 30 Human Binding pKi = 8.4 8.4 -2 15
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 331 1 1 2 3.8 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O 10.1016/j.bmcl.2020.127305
944 3618 None 30 Human Binding pKi = 8.4 8.4 -2 15
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 331 1 1 2 3.8 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O 10.1016/j.bmcl.2020.127305
CHEMBL324017 3618 None 30 Human Binding pKi = 8.4 8.4 -2 15
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 331 1 1 2 3.8 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O 10.1016/j.bmcl.2020.127305
164609519 184557 None 0 Human Binding pKi = 6.5 6.5 -251 5
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 441 7 1 5 4.1 COc1cc2c(cc1OC)CN(Cc1ccccc1CNC(=O)c1cccc(C#N)c1)CC2 10.1016/j.bmcl.2021.128047
CHEMBL4846574 184557 None 0 Human Binding pKi = 6.5 6.5 -251 5
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 441 7 1 5 4.1 COc1cc2c(cc1OC)CN(Cc1ccccc1CNC(=O)c1cccc(C#N)c1)CC2 10.1016/j.bmcl.2021.128047
172444635 195411 None 0 Human Binding pKi = 5.5 5.5 -1905 9
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells assessed as inhibition constant by competition binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells assessed as inhibition constant by competition binding assay
ChEMBL 488 10 2 5 4.4 COc1ccc(-c2ccccc2)c(CNC(=O)NCCCN2CCN(c3ccccc3OC)CC2)c1 10.1021/acs.jmedchem.3c00537
CHEMBL5403204 195411 None 0 Human Binding pKi = 5.5 5.5 -1905 9
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells assessed as inhibition constant by competition binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells assessed as inhibition constant by competition binding assay
ChEMBL 488 10 2 5 4.4 COc1ccc(-c2ccccc2)c(CNC(=O)NCCCN2CCN(c3ccccc3OC)CC2)c1 10.1021/acs.jmedchem.3c00537
137646281 157898 None 0 Human Binding pKi = 5.5 5.5 -6918 17
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 423 8 0 7 3.8 COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1 10.1021/acs.jmedchem.9b00412
CHEMBL4083252 157898 None 0 Human Binding pKi = 5.5 5.5 -6918 17
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 423 8 0 7 3.8 COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1 10.1021/acs.jmedchem.9b00412
72301 186224 None 46 Human Binding pKi = 6.5 6.5 -1 4
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cells after 1 hr
ChEMBL 355 4 0 5 3.4 COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2 10.1016/j.bmcl.2017.01.090
CHEMBL487182 186224 None 46 Human Binding pKi = 6.5 6.5 -1 4
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cells after 1 hr
ChEMBL 355 4 0 5 3.4 COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2 10.1016/j.bmcl.2017.01.090
10801923 177869 None 0 Human Binding pKi = 6.5 6.5 -2 2
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 269 2 2 3 2.7 COc1cc2c(cc1O)C(c1ccccc1)CNCC2 10.1016/j.bmcl.2020.127305
CHEMBL4642805 177869 None 0 Human Binding pKi = 6.5 6.5 -2 2
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 269 2 2 3 2.7 COc1cc2c(cc1O)C(c1ccccc1)CNCC2 10.1016/j.bmcl.2020.127305
44415690 80168 None 0 Human Binding pKi = 7.5 7.5 -14 6
Binding affinity at dopamine D5 receptorBinding affinity at dopamine D5 receptor
ChEMBL 473 2 1 5 5.1 Cc1cccc(C)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21 10.1016/j.bmcl.2006.06.022
CHEMBL213336 80168 None 0 Human Binding pKi = 7.5 7.5 -14 6
Binding affinity at dopamine D5 receptorBinding affinity at dopamine D5 receptor
ChEMBL 473 2 1 5 5.1 Cc1cccc(C)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21 10.1016/j.bmcl.2006.06.022
44439944 151958 None 0 Human Binding pKi = 7.5 7.5 -1 4
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 320 1 1 2 3.8 COc1ccc2c(c1)CCN(C)CCc1c([nH]c3ccccc13)C2 10.1016/j.bmcl.2006.11.093
CHEMBL396561 151958 None 0 Human Binding pKi = 7.5 7.5 -1 4
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 320 1 1 2 3.8 COc1ccc2c(c1)CCN(C)CCc1c([nH]c3ccccc13)C2 10.1016/j.bmcl.2006.11.093
145968810 165133 None 0 Human Binding pKi = 6.5 6.5 -33 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 381 8 2 4 3.5 CN(C)c1ccc(C(=O)NCCCCN2CCC(c3cccc(O)c3)C2)cc1 10.1016/j.bmcl.2018.03.084
CHEMBL4226226 165133 None 0 Human Binding pKi = 6.5 6.5 -33 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 381 8 2 4 3.5 CN(C)c1ccc(C(=O)NCCCCN2CCC(c3cccc(O)c3)C2)cc1 10.1016/j.bmcl.2018.03.084
42626293 151214 None 0 Human Binding pKi = 6.5 6.5 -4 5
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 349 6 0 3 3.2 O=C1Cc2ccccc2N1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2007.06.002
CHEMBL395933 151214 None 0 Human Binding pKi = 6.5 6.5 -4 5
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 349 6 0 3 3.2 O=C1Cc2ccccc2N1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2007.06.002
11186895 87541 None 22 Human Binding pKi = 6.5 6.5 -7 4
Displacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hr
ChEMBL 341 3 1 5 3.1 COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3OC)C[C@@H]21 10.1016/j.bmcl.2017.01.090
CHEMBL2334885 87541 None 22 Human Binding pKi = 6.5 6.5 -7 4
Displacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hr
ChEMBL 341 3 1 5 3.1 COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3OC)C[C@@H]21 10.1016/j.bmcl.2017.01.090
17755991 152387 None 0 Human Binding pKi = 6.5 6.5 -1 5
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 267 0 2 2 3.1 Oc1ccc2c(c1)CCCNCCc1ccccc1C2 10.1021/jm070388+
CHEMBL396950 152387 None 0 Human Binding pKi = 6.5 6.5 -1 5
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 267 0 2 2 3.1 Oc1ccc2c(c1)CCCNCCc1ccccc1C2 10.1021/jm070388+
90644063 112098 None 0 Human Binding pKi = 5.5 5.5 -138 10
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 327 6 0 3 3.7 Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1 10.1016/j.bmc.2014.04.026
CHEMBL3289648 112098 None 0 Human Binding pKi = 5.5 5.5 -138 10
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 327 6 0 3 3.7 Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1 10.1016/j.bmc.2014.04.026
11394805 13992 None 0 Human Binding pKi = 4.5 4.5 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 341 7 0 2 5.0 CCCN(CCC)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1196936 13992 None 0 Human Binding pKi = 4.5 4.5 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 341 7 0 2 5.0 CCCN(CCC)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL558766 13992 None 0 Human Binding pKi = 4.5 4.5 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 341 7 0 2 5.0 CCCN(CCC)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 10.1021/jm040889k
57401706 70195 None 0 Human Binding pKi = 5.5 5.5 -562 11
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 331 6 0 4 3.5 Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmc.2014.04.026
CHEMBL1940419 70195 None 0 Human Binding pKi = 5.5 5.5 -562 11
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 331 6 0 4 3.5 Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmc.2014.04.026
90644063 112098 None 0 Human Binding pKi = 5.5 5.5 -138 10
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 327 6 0 3 3.7 Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1 10.1016/j.bmc.2014.04.026
CHEMBL3289648 112098 None 0 Human Binding pKi = 5.5 5.5 -138 10
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 327 6 0 3 3.7 Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1 10.1016/j.bmc.2014.04.026
44436307 91792 None 0 Human Binding pKi = 7.5 7.5 19 3
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 383 6 0 3 3.9 O=C1c2ccccc2CN1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2007.06.002
CHEMBL240995 91792 None 0 Human Binding pKi = 7.5 7.5 19 3
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 383 6 0 3 3.9 O=C1c2ccccc2CN1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2007.06.002
10667433 148886 None 0 Human Binding pKi = 6.5 6.5 -10 4
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 379 7 0 4 3.2 COc1ccccc1N1CCN(CCCCN2C(=O)Cc3ccccc32)CC1 10.1016/j.bmc.2007.06.002
CHEMBL394080 148886 None 0 Human Binding pKi = 6.5 6.5 -10 4
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 379 7 0 4 3.2 COc1ccccc1N1CCN(CCCCN2C(=O)Cc3ccccc32)CC1 10.1016/j.bmc.2007.06.002
172458734 196494 None 0 Human Binding pKi = 5.5 5.5 -6165 9
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells assessed as inhibition constant by competition binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells assessed as inhibition constant by competition binding assay
ChEMBL 458 9 2 4 4.4 COc1ccccc1N1CCN(CCCNC(=O)NCc2ccccc2-c2ccccc2)CC1 10.1021/acs.jmedchem.3c00537
CHEMBL5425252 196494 None 0 Human Binding pKi = 5.5 5.5 -6165 9
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells assessed as inhibition constant by competition binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells assessed as inhibition constant by competition binding assay
ChEMBL 458 9 2 4 4.4 COc1ccccc1N1CCN(CCCNC(=O)NCc2ccccc2-c2ccccc2)CC1 10.1021/acs.jmedchem.3c00537
1621 2429 None 10 Human Binding pKi = 6.5 6.5 -151 44
Binding affinity towards Dopamine receptor D5Binding affinity towards Dopamine receptor D5
ChEMBL 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 10.1021/jm020153s
17 2429 None 10 Human Binding pKi = 6.5 6.5 -151 44
Binding affinity towards Dopamine receptor D5Binding affinity towards Dopamine receptor D5
ChEMBL 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 10.1021/jm020153s
5761 2429 None 10 Human Binding pKi = 6.5 6.5 -151 44
Binding affinity towards Dopamine receptor D5Binding affinity towards Dopamine receptor D5
ChEMBL 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 10.1021/jm020153s
CHEMBL263881 2429 None 10 Human Binding pKi = 6.5 6.5 -151 44
Binding affinity towards Dopamine receptor D5Binding affinity towards Dopamine receptor D5
ChEMBL 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 10.1021/jm020153s
DB04829 2429 None 10 Human Binding pKi = 6.5 6.5 -151 44
Binding affinity towards Dopamine receptor D5Binding affinity towards Dopamine receptor D5
ChEMBL 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 10.1021/jm020153s
155515982 170113 None 0 Human Binding pKi = 6.5 6.5 -1348 17
Displacement of [3H] SCH23390 from D5 receptor (unknown origin)Displacement of [3H] SCH23390 from D5 receptor (unknown origin)
ChEMBL 473 10 2 5 4.1 COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.9b01085
CHEMBL4442460 170113 None 0 Human Binding pKi = 6.5 6.5 -1348 17
Displacement of [3H] SCH23390 from D5 receptor (unknown origin)Displacement of [3H] SCH23390 from D5 receptor (unknown origin)
ChEMBL 473 10 2 5 4.1 COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.9b01085
164626655 186699 None 0 Human Binding pKi = 6.5 6.5 -100 5
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 441 7 1 5 4.1 COc1cc2c(cc1OC)CN(Cc1ccccc1CNC(=O)c1ccc(C#N)cc1)CC2 10.1016/j.bmcl.2021.128047
CHEMBL4878587 186699 None 0 Human Binding pKi = 6.5 6.5 -100 5
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 441 7 1 5 4.1 COc1cc2c(cc1OC)CN(Cc1ccccc1CNC(=O)c1ccc(C#N)cc1)CC2 10.1016/j.bmcl.2021.128047
137636498 156287 None 0 Human Binding pKi = 5.5 5.5 -1479 6
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 446 7 2 6 3.8 O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5ncccc45)CC3)cc2N1 10.1021/acs.jmedchem.7b00363
CHEMBL4064186 156287 None 0 Human Binding pKi = 5.5 5.5 -1479 6
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 446 7 2 6 3.8 O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5ncccc45)CC3)cc2N1 10.1021/acs.jmedchem.7b00363
11978813 721 None 58 Human Binding pKi = 6.5 6.5 -371 27
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 10.6019/CHEMBL5442175
11978813.0 721 None 58 Human Binding pKi = 6.5 6.5 -371 27
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 10.6019/CHEMBL5442175
5014 721 None 58 Human Binding pKi = 6.5 6.5 -371 27
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 10.6019/CHEMBL5442175
7672 721 None 58 Human Binding pKi = 6.5 6.5 -371 27
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 10.6019/CHEMBL5442175
CHEMBL2105760 721 None 58 Human Binding pKi = 6.5 6.5 -371 27
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 10.6019/CHEMBL5442175
DB09128 721 None 58 Human Binding pKi = 6.5 6.5 -371 27
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 10.6019/CHEMBL5442175
76321556 106433 None 0 Human Binding pKi = 5.5 5.5 -363 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 493 6 2 5 3.1 Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2 10.1021/jm401384w
CHEMBL3115578 106433 None 0 Human Binding pKi = 5.5 5.5 -363 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 493 6 2 5 3.1 Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2 10.1021/jm401384w
CHEMBL3139302 106433 None 0 Human Binding pKi = 5.5 5.5 -363 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 493 6 2 5 3.1 Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2 10.1021/jm401384w
76321556 106433 None 0 Human Binding pKi = 5.5 5.5 -363 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 493 6 2 5 3.1 Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2 10.1021/jm401384w
CHEMBL3115578 106433 None 0 Human Binding pKi = 5.5 5.5 -363 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 493 6 2 5 3.1 Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2 10.1021/jm401384w
CHEMBL3139302 106433 None 0 Human Binding pKi = 5.5 5.5 -363 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 493 6 2 5 3.1 Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2 10.1021/jm401384w
168510312 194964 None 2 Human Binding pKi = 6.5 6.5 -218 9
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells assessed as inhibition constant by competition binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells assessed as inhibition constant by competition binding assay
ChEMBL 520 9 2 4 6.4 COc1ccccc1N1CCN(CCCNC(=O)Nc2ccccc2-c2ccc(-c3ccccc3)cc2)CC1 10.1021/acs.jmedchem.3c00537
CHEMBL5394229 194964 None 2 Human Binding pKi = 6.5 6.5 -218 9
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells assessed as inhibition constant by competition binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells assessed as inhibition constant by competition binding assay
ChEMBL 520 9 2 4 6.4 COc1ccccc1N1CCN(CCCNC(=O)Nc2ccccc2-c2ccc(-c3ccccc3)cc2)CC1 10.1021/acs.jmedchem.3c00537
154703824 176731 None 1 Human Binding pKi = 5.5 5.5 -1348 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 471 11 2 2 6.5 CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1Cl 10.1021/acs.jmedchem.9b01835
CHEMBL4456007 176731 None 1 Human Binding pKi = 5.5 5.5 -1348 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 471 11 2 2 6.5 CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1Cl 10.1021/acs.jmedchem.9b01835
CHEMBL4597876 176731 None 1 Human Binding pKi = 5.5 5.5 -1348 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 471 11 2 2 6.5 CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1Cl 10.1021/acs.jmedchem.9b01835
763774 92183 None 2 Human Binding pKi = 5.5 5.5 -16 2
Binding affinity to human dopamine D5 receptor by radioligand binding assayBinding affinity to human dopamine D5 receptor by radioligand binding assay
ChEMBL 292 3 0 3 3.7 Clc1ccc(N2CCN(Cc3cccs3)CC2)cc1 10.1016/j.bmcl.2013.07.033
CHEMBL2420776 92183 None 2 Human Binding pKi = 5.5 5.5 -16 2
Binding affinity to human dopamine D5 receptor by radioligand binding assayBinding affinity to human dopamine D5 receptor by radioligand binding assay
ChEMBL 292 3 0 3 3.7 Clc1ccc(N2CCN(Cc3cccs3)CC2)cc1 10.1016/j.bmcl.2013.07.033
76321554 106459 None 0 Human Binding pKi = 5.5 5.5 -2290 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 395 4 2 3 3.5 Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2 10.1021/jm401384w
CHEMBL3115574 106459 None 0 Human Binding pKi = 5.5 5.5 -2290 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 395 4 2 3 3.5 Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2 10.1021/jm401384w
CHEMBL3139450 106459 None 0 Human Binding pKi = 5.5 5.5 -2290 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 395 4 2 3 3.5 Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2 10.1021/jm401384w
122191605 123787 None 0 Human Binding pKi = 5.4 5.4 -181 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 426 7 2 3 4.2 Brc1ccc(NCCN2CCN(CCc3c[nH]c4ccccc34)CC2)cc1 10.1021/acsmedchemlett.5b00131
CHEMBL3622097 123787 None 0 Human Binding pKi = 5.4 5.4 -181 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 426 7 2 3 4.2 Brc1ccc(NCCN2CCN(CCc3c[nH]c4ccccc34)CC2)cc1 10.1021/acsmedchemlett.5b00131
9992499 73411 None 0 Human Binding pKi = 6.4 6.4 -1 4
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 254 0 0 2 2.6 CN1CCc2ccccc2Cc2ccn(C)c2CC1 10.1021/jm050846j
CHEMBL201483 73411 None 0 Human Binding pKi = 6.4 6.4 -1 4
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 254 0 0 2 2.6 CN1CCc2ccccc2Cc2ccn(C)c2CC1 10.1021/jm050846j
2993172 127235 None 2 Human Binding pKi = 6.4 6.4 -1 3
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 297 6 0 3 3.0 c1ccc(Cc2ccccc2OCCN2CCOCC2)cc1 10.1021/jm049720x
CHEMBL365697 127235 None 2 Human Binding pKi = 6.4 6.4 -1 3
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 297 6 0 3 3.0 c1ccc(Cc2ccccc2OCCN2CCOCC2)cc1 10.1021/jm049720x
10476504 33495 None 1 Human Binding pKi = 5.4 5.4 -154 7
Displacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranes
ChEMBL 407 8 1 6 2.7 COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1 10.1016/j.bmc.2017.04.036
CHEMBL142020 33495 None 1 Human Binding pKi = 5.4 5.4 -154 7
Displacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranes
ChEMBL 407 8 1 6 2.7 COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1 10.1016/j.bmc.2017.04.036
10378389 205703 None 0 Human Binding pKi = 5.4 5.4 -8128 7
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 269 4 2 3 2.9 Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 10.1021/jm401384w
CHEMBL134807 205703 None 0 Human Binding pKi = 5.4 5.4 -8128 7
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 269 4 2 3 2.9 Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 10.1021/jm401384w
CHEMBL64553 205703 None 0 Human Binding pKi = 5.4 5.4 -8128 7
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 269 4 2 3 2.9 Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 10.1021/jm401384w
76321554 106459 None 0 Human Binding pKi = 5.4 5.4 -2290 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 395 4 2 3 3.5 Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2 10.1021/jm401384w
CHEMBL3115574 106459 None 0 Human Binding pKi = 5.4 5.4 -2290 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 395 4 2 3 3.5 Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2 10.1021/jm401384w
CHEMBL3139450 106459 None 0 Human Binding pKi = 5.4 5.4 -2290 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 395 4 2 3 3.5 Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2 10.1021/jm401384w
44415569 166029 None 0 Human Binding pKi = 7.4 7.4 -23 6
Binding affinity at dopamine D5 receptorBinding affinity at dopamine D5 receptor
ChEMBL 505 4 1 7 4.5 COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21 10.1016/j.bmcl.2006.06.022
CHEMBL425069 166029 None 0 Human Binding pKi = 7.4 7.4 -23 6
Binding affinity at dopamine D5 receptorBinding affinity at dopamine D5 receptor
ChEMBL 505 4 1 7 4.5 COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21 10.1016/j.bmcl.2006.06.022
75201901 166520 None 21 Human Binding pKi = 7.4 7.4 1 24
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method
ChEMBL 356 3 0 6 4.9 Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12 10.1021/acs.jmedchem.9b00351
CHEMBL4277264 166520 None 21 Human Binding pKi = 7.4 7.4 1 24
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method
ChEMBL 356 3 0 6 4.9 Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12 10.1021/acs.jmedchem.9b00351
1353 1911 None 63 Human Binding pKi = 7.4 7.4 -54 85
Inhibition of human dopamine D5 receptorInhibition of human dopamine D5 receptor
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm1013693
3559 1911 None 63 Human Binding pKi = 7.4 7.4 -54 85
Inhibition of human dopamine D5 receptorInhibition of human dopamine D5 receptor
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm1013693
3559.0 1911 None 63 Human Binding pKi = 7.4 7.4 -54 85
Inhibition of human dopamine D5 receptorInhibition of human dopamine D5 receptor
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm1013693
86 1911 None 63 Human Binding pKi = 7.4 7.4 -54 85
Inhibition of human dopamine D5 receptorInhibition of human dopamine D5 receptor
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm1013693
CHEMBL54 1911 None 63 Human Binding pKi = 7.4 7.4 -54 85
Inhibition of human dopamine D5 receptorInhibition of human dopamine D5 receptor
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm1013693
DB00502 1911 None 63 Human Binding pKi = 7.4 7.4 -54 85
Inhibition of human dopamine D5 receptorInhibition of human dopamine D5 receptor
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm1013693
44408818 140252 None 0 Human Binding pKi = 7.4 7.4 -12 6
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 281 1 0 2 3.3 COc1ccc2c(c1)CCN(C)CCc1ccccc1C2 10.1016/j.bmcl.2006.11.093
CHEMBL380330 140252 None 0 Human Binding pKi = 7.4 7.4 -12 6
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 281 1 0 2 3.3 COc1ccc2c(c1)CCN(C)CCc1ccccc1C2 10.1016/j.bmcl.2006.11.093
122180956 121836 None 0 Human Binding pKi = 5.4 5.4 -380 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranes
ChEMBL 404 7 1 3 4.8 CCCN(CCNC(=O)/N=N/c1cc(F)c(F)c(F)c1)C1Cc2ccccc2C1 10.1016/j.bmc.2014.12.012
CHEMBL3589577 121836 None 0 Human Binding pKi = 5.4 5.4 -380 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranes
ChEMBL 404 7 1 3 4.8 CCCN(CCNC(=O)/N=N/c1cc(F)c(F)c(F)c1)C1Cc2ccccc2C1 10.1016/j.bmc.2014.12.012
137635364 156351 None 0 Human Binding pKi = 5.4 5.4 -12302 6
Displacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranes
ChEMBL 439 10 1 6 3.0 O=C(NCCCCN1CCN(c2ccccc2OCCF)CC1)c1cc2ccccn2n1 10.1016/j.bmc.2017.04.036
CHEMBL4064974 156351 None 0 Human Binding pKi = 5.4 5.4 -12302 6
Displacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranes
ChEMBL 439 10 1 6 3.0 O=C(NCCCCN1CCN(c2ccccc2OCCF)CC1)c1cc2ccccn2n1 10.1016/j.bmc.2017.04.036
CHEMBL4074669 156351 None 0 Human Binding pKi = 5.4 5.4 -12302 6
Displacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranes
ChEMBL 439 10 1 6 3.0 O=C(NCCCCN1CCN(c2ccccc2OCCF)CC1)c1cc2ccccn2n1 10.1016/j.bmc.2017.04.036
57393083 70191 None 0 Human Binding pKi = 5.4 5.4 -616 7
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 314 6 0 4 2.8 Fc1ccc(CCCCN2CCN(c3ncccn3)CC2)cc1 10.1016/j.bmc.2014.04.026
CHEMBL1940415 70191 None 0 Human Binding pKi = 5.4 5.4 -616 7
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 314 6 0 4 2.8 Fc1ccc(CCCCN2CCN(c3ncccn3)CC2)cc1 10.1016/j.bmc.2014.04.026
10378389 205703 None 0 Human Binding pKi = 5.4 5.4 -8128 7
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 269 4 2 3 2.9 Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 10.1021/jm401384w
CHEMBL134807 205703 None 0 Human Binding pKi = 5.4 5.4 -8128 7
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 269 4 2 3 2.9 Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 10.1021/jm401384w
CHEMBL64553 205703 None 0 Human Binding pKi = 5.4 5.4 -8128 7
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 269 4 2 3 2.9 Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 10.1021/jm401384w
56594533 70622 None 0 Human Binding pKi = 6.4 6.4 1 2
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cells
ChEMBL 304 0 1 1 4.2 C[C@@H]1Cc2c([nH]c3ccccc23)Cc2ccccc2CCN1C 10.1021/jm200676f
CHEMBL1949726 70622 None 0 Human Binding pKi = 6.4 6.4 1 2
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cells
ChEMBL 304 0 1 1 4.2 C[C@@H]1Cc2c([nH]c3ccccc23)Cc2ccccc2CCN1C 10.1021/jm200676f
172458161 196394 None 0 Human Binding pKi = 5.4 5.4 -1862 9
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells assessed as inhibition constant by competition binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells assessed as inhibition constant by competition binding assay
ChEMBL 562 15 2 7 4.7 COCCOCCOc1ccc(NC(=O)NCCCN2CCN(c3ccccc3OC)CC2)c(-c2ccccc2)c1 10.1021/acs.jmedchem.3c00537
CHEMBL5422870 196394 None 0 Human Binding pKi = 5.4 5.4 -1862 9
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells assessed as inhibition constant by competition binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells assessed as inhibition constant by competition binding assay
ChEMBL 562 15 2 7 4.7 COCCOCCOc1ccc(NC(=O)NCCCN2CCN(c3ccccc3OC)CC2)c(-c2ccccc2)c1 10.1021/acs.jmedchem.3c00537
3929516 107426 None 4 Human Binding pKi = 6.4 6.4 -66 17
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 343 4 0 2 4.7 CN1C2CCC1CC(OC(c1ccc(F)cc1)c1ccc(F)cc1)C2 10.6019/CHEMBL5442175
CHEMBL317757 107426 None 4 Human Binding pKi = 6.4 6.4 -66 17
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 343 4 0 2 4.7 CN1C2CCC1CC(OC(c1ccc(F)cc1)c1ccc(F)cc1)C2 10.6019/CHEMBL5442175
CHEMBL543113 107426 None 4 Human Binding pKi = 6.4 6.4 -66 17
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 343 4 0 2 4.7 CN1C2CCC1CC(OC(c1ccc(F)cc1)c1ccc(F)cc1)C2 10.6019/CHEMBL5442175
132060461 195423 None 0 Human Binding pKi = 5.4 5.4 -199 19
Binding affinity to human dopamine D5 receptor assessed as inhibition constantBinding affinity to human dopamine D5 receptor assessed as inhibition constant
ChEMBL 421 6 0 4 4.9 CCCN1CCN(c2ccc3c(c2)C(N(C)C(=O)OCc2ccccc2)CCC3)CC1 10.1016/j.ejmech.2022.114696
CHEMBL5403404 195423 None 0 Human Binding pKi = 5.4 5.4 -199 19
Binding affinity to human dopamine D5 receptor assessed as inhibition constantBinding affinity to human dopamine D5 receptor assessed as inhibition constant
ChEMBL 421 6 0 4 4.9 CCCN1CCN(c2ccc3c(c2)C(N(C)C(=O)OCc2ccccc2)CCC3)CC1 10.1016/j.ejmech.2022.114696
168269421 190071 None 0 Human Binding pKi = 5.4 5.4 -26 3
Displacement of [3H]-SCH23390 from human D5 receptor expressed in HEK293 cell membrane by competitive inhibition based analysisDisplacement of [3H]-SCH23390 from human D5 receptor expressed in HEK293 cell membrane by competitive inhibition based analysis
ChEMBL 390 5 1 2 5.3 Fc1ccc(COC2CCN(Cc3cc4ccc(Cl)cc4[nH]3)CC2)cc1F 10.1016/j.bmcl.2022.128615
CHEMBL5170670 190071 None 0 Human Binding pKi = 5.4 5.4 -26 3
Displacement of [3H]-SCH23390 from human D5 receptor expressed in HEK293 cell membrane by competitive inhibition based analysisDisplacement of [3H]-SCH23390 from human D5 receptor expressed in HEK293 cell membrane by competitive inhibition based analysis
ChEMBL 390 5 1 2 5.3 Fc1ccc(COC2CCN(Cc3cc4ccc(Cl)cc4[nH]3)CC2)cc1F 10.1016/j.bmcl.2022.128615
6917970 3691 None 40 Human Binding pKi = 8.4 8.4 1 34
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 327 2 2 5 2.8 COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O 10.1016/j.bmc.2009.08.028
8370 3691 None 40 Human Binding pKi = 8.4 8.4 1 34
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 327 2 2 5 2.8 COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O 10.1016/j.bmc.2009.08.028
CHEMBL487387 3691 None 40 Human Binding pKi = 8.4 8.4 1 34
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 327 2 2 5 2.8 COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O 10.1016/j.bmc.2009.08.028
56589560 70621 None 0 Human Binding pKi = 8.4 8.4 1 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cells
ChEMBL 304 0 1 1 4.2 C[C@H]1Cc2c([nH]c3ccccc23)Cc2ccccc2CCN1C 10.1021/jm200676f
CHEMBL1949725 70621 None 0 Human Binding pKi = 8.4 8.4 1 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cells
ChEMBL 304 0 1 1 4.2 C[C@H]1Cc2c([nH]c3ccccc23)Cc2ccccc2CCN1C 10.1021/jm200676f
17756101 98637 None 0 Human Binding pKi = 8.3 8.3 -1 6
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 295 1 0 2 3.7 COc1ccc2c(c1)CCN(C)CCCc1ccccc1C2 10.1021/jm070388+
CHEMBL276778 98637 None 0 Human Binding pKi = 8.3 8.3 -1 6
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 295 1 0 2 3.7 COc1ccc2c(c1)CCN(C)CCCc1ccccc1C2 10.1021/jm070388+
46231995 203991 None 0 Human Binding pKi = 8.3 8.3 -7 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 434 2 1 4 5.6 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc([N+](=O)[O-])c4)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
CHEMBL605339 203991 None 0 Human Binding pKi = 8.3 8.3 -7 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 434 2 1 4 5.6 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc([N+](=O)[O-])c4)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
11573628 74725 None 0 Human Binding pKi = 8.3 8.3 -1 4
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 301 0 1 2 3.7 CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1 10.1021/jm051237e
CHEMBL203047 74725 None 0 Human Binding pKi = 8.3 8.3 -1 4
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 301 0 1 2 3.7 CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1 10.1021/jm051237e
10472143 119341 None 0 Human Binding pKi = 6.4 6.4 -891 16
Binding affinity towards Dopamine receptor D5Binding affinity towards Dopamine receptor D5
ChEMBL 335 1 1 2 3.0 C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 10.1021/jm020153s
CHEMBL343755 119341 None 0 Human Binding pKi = 6.4 6.4 -891 16
Binding affinity towards Dopamine receptor D5Binding affinity towards Dopamine receptor D5
ChEMBL 335 1 1 2 3.0 C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 10.1021/jm020153s
154703922 176394 None 1 Human Binding pKi = 5.4 5.4 -1995 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 482 11 1 2 7.2 CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1Cl 10.1021/acs.jmedchem.9b01835
CHEMBL4590211 176394 None 1 Human Binding pKi = 5.4 5.4 -1995 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 482 11 1 2 7.2 CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1Cl 10.1021/acs.jmedchem.9b01835
CHEMBL4595146 176394 None 1 Human Binding pKi = 5.4 5.4 -1995 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 482 11 1 2 7.2 CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1Cl 10.1021/acs.jmedchem.9b01835
13373172 202239 None 0 Human Binding pKi = 7.4 7.4 3 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 251 0 1 2 3.0 Oc1ccc2c(c1)CCN1Cc3ccccc3CC21 10.1016/j.bmc.2009.08.028
CHEMBL593897 202239 None 0 Human Binding pKi = 7.4 7.4 3 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 251 0 1 2 3.0 Oc1ccc2c(c1)CCN1Cc3ccccc3CC21 10.1016/j.bmc.2009.08.028
44414299 139312 None 0 Human Binding pKi = 6.4 6.4 -19 2
Binding affinity to human dopamine D5 receptorBinding affinity to human dopamine D5 receptor
ChEMBL 495 9 0 4 6.6 CCN(CC)CCCOc1cccc(N2C(=O)/C(=N/c3cccc(C(F)(F)F)c3)c3ccccc32)c1 10.1016/j.bmcl.2006.05.025
CHEMBL378825 139312 None 0 Human Binding pKi = 6.4 6.4 -19 2
Binding affinity to human dopamine D5 receptorBinding affinity to human dopamine D5 receptor
ChEMBL 495 9 0 4 6.6 CCN(CC)CCCOc1cccc(N2C(=O)/C(=N/c3cccc(C(F)(F)F)c3)c3ccccc32)c1 10.1016/j.bmcl.2006.05.025
2402 3370 None 38 Human Binding pKi = 4.4 4.4 -81 25
Binding affinity to human dopamine D5 receptorBinding affinity to human dopamine D5 receptor
ChEMBL 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O 10.1039/C4MD00066H
5095 3370 None 38 Human Binding pKi = 4.4 4.4 -81 25
Binding affinity to human dopamine D5 receptorBinding affinity to human dopamine D5 receptor
ChEMBL 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O 10.1039/C4MD00066H
5095.0 3370 None 38 Human Binding pKi = 4.4 4.4 -81 25
Binding affinity to human dopamine D5 receptorBinding affinity to human dopamine D5 receptor
ChEMBL 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O 10.1039/C4MD00066H
7295 3370 None 38 Human Binding pKi = 4.4 4.4 -81 25
Binding affinity to human dopamine D5 receptorBinding affinity to human dopamine D5 receptor
ChEMBL 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O 10.1039/C4MD00066H
CHEMBL589 3370 None 38 Human Binding pKi = 4.4 4.4 -81 25
Binding affinity to human dopamine D5 receptorBinding affinity to human dopamine D5 receptor
ChEMBL 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O 10.1039/C4MD00066H
DB00268 3370 None 38 Human Binding pKi = 4.4 4.4 -81 25
Binding affinity to human dopamine D5 receptorBinding affinity to human dopamine D5 receptor
ChEMBL 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O 10.1039/C4MD00066H
135409453 3773 None 26 Human Binding pKi = 5.4 5.4 -537 19
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.6019/CHEMBL5442175
226 3773 None 26 Human Binding pKi = 5.4 5.4 -537 19
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.6019/CHEMBL5442175
CHEMBL76370 3773 None 26 Human Binding pKi = 5.4 5.4 -537 19
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.6019/CHEMBL5442175
7077 66980 None 21 Human Binding pKi = 6.4 6.4 -4 5
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 255 6 0 2 3.2 CN(C)CCOc1ccccc1Cc1ccccc1 10.1021/jm049720x
CHEMBL186720 66980 None 21 Human Binding pKi = 6.4 6.4 -4 5
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 255 6 0 2 3.2 CN(C)CCOc1ccccc1Cc1ccccc1 10.1021/jm049720x
CHEMBL3925724 66980 None 21 Human Binding pKi = 6.4 6.4 -4 5
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 255 6 0 2 3.2 CN(C)CCOc1ccccc1Cc1ccccc1 10.1021/jm049720x
57403525 70178 None 0 Human Binding pKi = 6.4 6.4 -275 10
Displacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation counting
ChEMBL 361 6 1 2 4.8 OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.07.018
CHEMBL1940402 70178 None 0 Human Binding pKi = 6.4 6.4 -275 10
Displacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation counting
ChEMBL 361 6 1 2 4.8 OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.07.018
156012196 177437 None 0 Human Binding pKi = 6.4 6.4 -1 4
Binding affinity to human D5 receptorBinding affinity to human D5 receptor
ChEMBL 296 1 2 4 2.7 COc1cc2c3c(c1O)-c1cc(N)ccc1CC3N(C)CC2 10.1016/j.bmcl.2020.127053
CHEMBL4637246 177437 None 0 Human Binding pKi = 6.4 6.4 -1 4
Binding affinity to human D5 receptorBinding affinity to human D5 receptor
ChEMBL 296 1 2 4 2.7 COc1cc2c3c(c1O)-c1cc(N)ccc1CC3N(C)CC2 10.1016/j.bmcl.2020.127053
11716438 140969 None 0 Human Binding pKi = 7.4 7.4 -8 4
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2cc(O)ccc2CC1 10.1021/jm051237e
CHEMBL382010 140969 None 0 Human Binding pKi = 7.4 7.4 -8 4
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2cc(O)ccc2CC1 10.1021/jm051237e
137640189 157045 None 0 Human Binding pKi = 5.4 5.4 -5495 6
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 466 7 3 7 2.6 O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1 10.1021/acs.jmedchem.7b00363
CHEMBL4072780 157045 None 0 Human Binding pKi = 5.4 5.4 -5495 6
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 466 7 3 7 2.6 O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1 10.1021/acs.jmedchem.7b00363
164614469 184887 None 0 Human Binding pKi = 5.4 5.4 1 2
Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)
ChEMBL 341 1 0 3 3.9 C[Si](C)(C)C#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 10.1016/j.bmcl.2021.128008
CHEMBL4851349 184887 None 0 Human Binding pKi = 5.4 5.4 1 2
Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)
ChEMBL 341 1 0 3 3.9 C[Si](C)(C)C#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 10.1016/j.bmcl.2021.128008
154726353 176428 None 1 Human Binding pKi = 5.4 5.4 -371 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 467 12 2 3 5.9 CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(Cl)ccc1OC 10.1021/acs.jmedchem.9b01835
CHEMBL4577162 176428 None 1 Human Binding pKi = 5.4 5.4 -371 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 467 12 2 3 5.9 CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(Cl)ccc1OC 10.1021/acs.jmedchem.9b01835
CHEMBL4595382 176428 None 1 Human Binding pKi = 5.4 5.4 -371 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 467 12 2 3 5.9 CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(Cl)ccc1OC 10.1021/acs.jmedchem.9b01835
4011 82440 None 34 Human Binding pKi = 6.4 6.4 -57 23
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 277 4 1 1 4.2 CNCCCC12CCC(c3ccccc31)c1ccccc12 10.1016/j.bmcl.2008.09.012
CHEMBL21731 82440 None 34 Human Binding pKi = 6.4 6.4 -57 23
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 277 4 1 1 4.2 CNCCCC12CCC(c3ccccc31)c1ccccc12 10.1016/j.bmcl.2008.09.012
44396220 125490 None 0 Human Binding pKi = 7.4 7.4 -1 6
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 295 6 0 2 4.1 c1ccc(Cc2ccccc2OCCN2CCCCC2)cc1 10.1021/jm049720x
CHEMBL364565 125490 None 0 Human Binding pKi = 7.4 7.4 -1 6
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 295 6 0 2 4.1 c1ccc(Cc2ccccc2OCCN2CCCCC2)cc1 10.1021/jm049720x
11212939 69182 None 0 Rat Binding pKi = 5.4 5.4 -45 3
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 443 7 1 4 4.5 COc1ccc2c(c1)N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@@H]1CC2 10.1021/jm049031l
CHEMBL192439 69182 None 0 Rat Binding pKi = 5.4 5.4 -45 3
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 443 7 1 4 4.5 COc1ccc2c(c1)N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@@H]1CC2 10.1021/jm049031l
145988693 167262 None 0 Human Binding pKi = 6.4 6.4 -17 17
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assay
ChEMBL 524 7 1 3 7.1 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1016/j.bmcl.2018.10.036
CHEMBL4291048 167262 None 0 Human Binding pKi = 6.4 6.4 -17 17
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assay
ChEMBL 524 7 1 3 7.1 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1016/j.bmcl.2018.10.036
145969934 165140 None 0 Human Binding pKi = 6.4 6.4 -39 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 261 7 1 2 4.2 CCCCCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
CHEMBL4226336 165140 None 0 Human Binding pKi = 6.4 6.4 -39 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 261 7 1 2 4.2 CCCCCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
155770281 177852 None 0 Human Binding pKi = 5.4 5.4 -5 9
Binding affinity to dopamine D5 receptor (unknown origin)Binding affinity to dopamine D5 receptor (unknown origin)
ChEMBL 517 4 1 2 7.6 CC(=O)N1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1 10.1021/acs.jmedchem.0c00745
CHEMBL4642592 177852 None 0 Human Binding pKi = 5.4 5.4 -5 9
Binding affinity to dopamine D5 receptor (unknown origin)Binding affinity to dopamine D5 receptor (unknown origin)
ChEMBL 517 4 1 2 7.6 CC(=O)N1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1 10.1021/acs.jmedchem.0c00745
156011597 177484 None 0 Human Binding pKi = 6.4 6.4 -3 2
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 373 3 2 3 4.0 C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2Br)C1 10.1016/j.bmcl.2020.127305
CHEMBL4637938 177484 None 0 Human Binding pKi = 6.4 6.4 -3 2
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 373 3 2 3 4.0 C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2Br)C1 10.1016/j.bmcl.2020.127305
172438970 195292 None 0 Human Binding pKi = 5.4 5.4 -776 9
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells assessed as inhibition constant by competition binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells assessed as inhibition constant by competition binding assay
ChEMBL 444 8 2 4 4.7 COc1ccccc1N1CCN(CCCNC(=O)Nc2ccccc2-c2ccccc2)CC1 10.1021/acs.jmedchem.3c00537
CHEMBL5400232 195292 None 0 Human Binding pKi = 5.4 5.4 -776 9
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells assessed as inhibition constant by competition binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells assessed as inhibition constant by competition binding assay
ChEMBL 444 8 2 4 4.7 COc1ccccc1N1CCN(CCCNC(=O)Nc2ccccc2-c2ccccc2)CC1 10.1021/acs.jmedchem.3c00537
76325150 106478 None 0 Human Binding pKi = 5.3 5.3 -4897 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 395 4 2 3 3.5 Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2 10.1021/jm401384w
CHEMBL3115575 106478 None 0 Human Binding pKi = 5.3 5.3 -4897 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 395 4 2 3 3.5 Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2 10.1021/jm401384w
CHEMBL3139554 106478 None 0 Human Binding pKi = 5.3 5.3 -4897 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 395 4 2 3 3.5 Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2 10.1021/jm401384w
156017431 177882 None 0 Human Binding pKi = 7.3 7.3 -3 2
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 317 2 1 3 3.7 COc1cc2c(cc1O)C(c1ccccc1Cl)CN(C)CC2 10.1016/j.bmcl.2020.127305
CHEMBL4643069 177882 None 0 Human Binding pKi = 7.3 7.3 -3 2
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 317 2 1 3 3.7 COc1cc2c(cc1O)C(c1ccccc1Cl)CN(C)CC2 10.1016/j.bmcl.2020.127305
76325150 106478 None 0 Human Binding pKi = 5.3 5.3 -4897 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 395 4 2 3 3.5 Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2 10.1021/jm401384w
CHEMBL3115575 106478 None 0 Human Binding pKi = 5.3 5.3 -4897 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 395 4 2 3 3.5 Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2 10.1021/jm401384w
CHEMBL3139554 106478 None 0 Human Binding pKi = 5.3 5.3 -4897 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 395 4 2 3 3.5 Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2 10.1021/jm401384w
130442572 172011 None 0 Human Binding pKi = 7.3 7.3 3 24
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method
ChEMBL 395 3 0 5 6.0 FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12 10.1021/acs.jmedchem.9b00351
CHEMBL4469848 172011 None 0 Human Binding pKi = 7.3 7.3 3 24
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method
ChEMBL 395 3 0 5 6.0 FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12 10.1021/acs.jmedchem.9b00351
156018764 177900 None 0 Human Binding pKi = 7.3 7.3 -2 2
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 361 2 1 3 3.8 COc1cc2c(cc1O)C(c1ccccc1Br)CN(C)CC2 10.1016/j.bmcl.2020.127305
CHEMBL4643426 177900 None 0 Human Binding pKi = 7.3 7.3 -2 2
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 361 2 1 3 3.8 COc1cc2c(cc1O)C(c1ccccc1Br)CN(C)CC2 10.1016/j.bmcl.2020.127305
156018236 178017 None 0 Human Binding pKi = 6.3 6.3 2 3
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 377 4 1 3 4.9 C=CCN1CCc2cc(OC)c(O)cc2C(c2c(Cl)cccc2Cl)C1 10.1016/j.bmcl.2020.127305
CHEMBL4645139 178017 None 0 Human Binding pKi = 6.3 6.3 2 3
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 377 4 1 3 4.9 C=CCN1CCc2cc(OC)c(O)cc2C(c2c(Cl)cccc2Cl)C1 10.1016/j.bmcl.2020.127305
1353 1911 None 63 Human Binding pKi = 7.3 7.3 -54 85
Displacement of [3H]SCH233930 from human D5 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D5 receptor expressed in HEK cells
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1016/j.bmcl.2011.04.098
3559 1911 None 63 Human Binding pKi = 7.3 7.3 -54 85
Displacement of [3H]SCH233930 from human D5 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D5 receptor expressed in HEK cells
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1016/j.bmcl.2011.04.098
3559.0 1911 None 63 Human Binding pKi = 7.3 7.3 -54 85
Displacement of [3H]SCH233930 from human D5 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D5 receptor expressed in HEK cells
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1016/j.bmcl.2011.04.098
86 1911 None 63 Human Binding pKi = 7.3 7.3 -54 85
Displacement of [3H]SCH233930 from human D5 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D5 receptor expressed in HEK cells
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1016/j.bmcl.2011.04.098
CHEMBL54 1911 None 63 Human Binding pKi = 7.3 7.3 -54 85
Displacement of [3H]SCH233930 from human D5 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D5 receptor expressed in HEK cells
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1016/j.bmcl.2011.04.098
DB00502 1911 None 63 Human Binding pKi = 7.3 7.3 -54 85
Displacement of [3H]SCH233930 from human D5 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D5 receptor expressed in HEK cells
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1016/j.bmcl.2011.04.098
122177642 121274 None 0 Human Binding pKi = 4.3 4.3 -21877 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis
ChEMBL 551 18 1 8 4.6 C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1 10.1021/jm501889t
CHEMBL3577343 121274 None 0 Human Binding pKi = 4.3 4.3 -21877 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis
ChEMBL 551 18 1 8 4.6 C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1 10.1021/jm501889t
156014482 177317 None 0 Human Binding pKi = 6.3 6.3 -3 2
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 303 2 2 3 3.3 COc1cc2c(cc1O)C(c1ccccc1Cl)CNCC2 10.1016/j.bmcl.2020.127305
CHEMBL4635423 177317 None 0 Human Binding pKi = 6.3 6.3 -3 2
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 303 2 2 3 3.3 COc1cc2c(cc1O)C(c1ccccc1Cl)CNCC2 10.1016/j.bmcl.2020.127305
156010755 177246 None 0 Human Binding pKi = 7.3 7.3 2 2
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 351 2 1 3 4.3 COc1cc2c(cc1O)C(c1c(Cl)cccc1Cl)CN(C)CC2 10.1016/j.bmcl.2020.127305
CHEMBL4633950 177246 None 0 Human Binding pKi = 7.3 7.3 2 2
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 351 2 1 3 4.3 COc1cc2c(cc1O)C(c1c(Cl)cccc1Cl)CN(C)CC2 10.1016/j.bmcl.2020.127305
5074 3332 None 53 Human Binding pKi = 6.3 6.3 -741 37
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 10.6019/CHEMBL5442175
97 3332 None 53 Human Binding pKi = 6.3 6.3 -741 37
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 10.6019/CHEMBL5442175
CHEMBL267777 3332 None 53 Human Binding pKi = 6.3 6.3 -741 37
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 10.6019/CHEMBL5442175
DB12693 3332 None 53 Human Binding pKi = 6.3 6.3 -741 37
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 10.6019/CHEMBL5442175
44439945 93420 None 0 Human Binding pKi = 8.3 8.3 -1 4
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 306 0 2 2 3.5 CN1CCc2cc(O)ccc2Cc2[nH]c3ccccc3c2CC1 10.1016/j.bmcl.2006.11.093
CHEMBL245571 93420 None 0 Human Binding pKi = 8.3 8.3 -1 4
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 306 0 2 2 3.5 CN1CCc2cc(O)ccc2Cc2[nH]c3ccccc3c2CC1 10.1016/j.bmcl.2006.11.093
168280742 191193 None 0 Human Binding pKi = 8.3 8.3 -1 4
Competitive binding affinity to human D5R in transfected cellsCompetitive binding affinity to human D5R in transfected cells
ChEMBL 230 4 0 2 3.5 O=Cc1ccc(-c2ccccc2OCF)cc1 10.1021/acs.jmedchem.2c00949
CHEMBL5187578 191193 None 0 Human Binding pKi = 8.3 8.3 -1 4
Competitive binding affinity to human D5R in transfected cellsCompetitive binding affinity to human D5R in transfected cells
ChEMBL 230 4 0 2 3.5 O=Cc1ccc(-c2ccccc2OCF)cc1 10.1021/acs.jmedchem.2c00949
11452916 203285 None 0 Human Binding pKi = 8.3 8.3 -7 3
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 420 3 2 4 3.7 CCS(=O)(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C 10.1016/j.bmcl.2009.12.100
CHEMBL600986 203285 None 0 Human Binding pKi = 8.3 8.3 -7 3
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 420 3 2 4 3.7 CCS(=O)(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C 10.1016/j.bmcl.2009.12.100
44275670 11993 None 0 Human Binding pKi = 8.3 8.3 - 1
Binding affinity against human Dopamine receptor D4 versus hD2, hD3 receptorBinding affinity against human Dopamine receptor D4 versus hD2, hD3 receptor
ChEMBL 457 8 2 5 3.7 COc1cccc(CN2CC[C@H](NC(=O)c3cc(Cl)c(NC(=O)C4CC4)cc3OC)C2)c1 10.1021/jm030480f
CHEMBL1183144 11993 None 0 Human Binding pKi = 8.3 8.3 - 1
Binding affinity against human Dopamine receptor D4 versus hD2, hD3 receptorBinding affinity against human Dopamine receptor D4 versus hD2, hD3 receptor
ChEMBL 457 8 2 5 3.7 COc1cccc(CN2CC[C@H](NC(=O)c3cc(Cl)c(NC(=O)C4CC4)cc3OC)C2)c1 10.1021/jm030480f
CHEMBL282116 11993 None 0 Human Binding pKi = 8.3 8.3 - 1
Binding affinity against human Dopamine receptor D4 versus hD2, hD3 receptorBinding affinity against human Dopamine receptor D4 versus hD2, hD3 receptor
ChEMBL 457 8 2 5 3.7 COc1cccc(CN2CC[C@H](NC(=O)c3cc(Cl)c(NC(=O)C4CC4)cc3OC)C2)c1 10.1021/jm030480f
11235174 202837 None 0 Human Binding pKi = 8.2 8.2 -11 3
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 406 2 2 4 3.4 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(NS(C)(=O)=O)cc3CC[C@@H]21 10.1016/j.bmcl.2009.12.100
CHEMBL597909 202837 None 0 Human Binding pKi = 8.2 8.2 -11 3
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 406 2 2 4 3.4 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(NS(C)(=O)=O)cc3CC[C@@H]21 10.1016/j.bmcl.2009.12.100
11374299 203064 None 0 Human Binding pKi = 8.2 8.2 -11 3
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 448 5 1 4 4.0 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C3CCC3)S(C)(=O)=O)cc2)C1 10.1016/j.bmcl.2009.12.100
CHEMBL599282 203064 None 0 Human Binding pKi = 8.2 8.2 -11 3
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 448 5 1 4 4.0 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C3CCC3)S(C)(=O)=O)cc2)C1 10.1016/j.bmcl.2009.12.100
156020547 178263 None 0 Human Binding pKi = 6.3 6.3 -12 2
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 387 4 1 3 4.3 C=CCN1CCc2cc(OC)c(O)cc2C(c2ccccc2Br)C1 10.1016/j.bmcl.2020.127305
CHEMBL4649012 178263 None 0 Human Binding pKi = 6.3 6.3 -12 2
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 387 4 1 3 4.3 C=CCN1CCc2cc(OC)c(O)cc2C(c2ccccc2Br)C1 10.1016/j.bmcl.2020.127305
44436304 90483 None 0 Human Binding pKi = 6.3 6.3 -3 3
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 396 6 0 5 3.7 O=c1c2ccccc2ncn1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2007.06.002
CHEMBL238718 90483 None 0 Human Binding pKi = 6.3 6.3 -3 3
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 396 6 0 5 3.7 O=c1c2ccccc2ncn1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2007.06.002
44427970 152699 None 0 Human Binding pKi = 6.3 6.3 1 5
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 325 2 0 3 3.7 COc1cc2c(cc1OC)Cc1ccccc1CCCN(C)CC2 10.1021/jm070388+
CHEMBL397207 152699 None 0 Human Binding pKi = 6.3 6.3 1 5
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 325 2 0 3 3.7 COc1cc2c(cc1OC)Cc1ccccc1CCCN(C)CC2 10.1021/jm070388+
56593482 3941 None 6 Human Binding pKi = 6.3 6.3 -467 9
Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.
ChEMBL 462 7 1 5 4.6 O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl nan
7650 3941 None 6 Human Binding pKi = 6.3 6.3 -467 9
Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.
ChEMBL 462 7 1 5 4.6 O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl nan
CHEMBL2165119 3941 None 6 Human Binding pKi = 6.3 6.3 -467 9
Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.
ChEMBL 462 7 1 5 4.6 O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl nan
71528209 87006 None 0 Human Binding pKi = 5.3 5.3 -812 7
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 465 6 0 3 5.8 CC1=CC(C)=[N+]2C1=C(c1ccc(OCCCN3CCCCC3)cc1)c1c(C)cc(C)n1[B-]2(F)F 10.1021/ml300383n
CHEMBL2323582 87006 None 0 Human Binding pKi = 5.3 5.3 -812 7
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 465 6 0 3 5.8 CC1=CC(C)=[N+]2C1=C(c1ccc(OCCCN3CCCCC3)cc1)c1c(C)cc(C)n1[B-]2(F)F 10.1021/ml300383n
53325242 57086 None 0 Human Binding pKi = 6.3 6.3 -2 17
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assay
ChEMBL 537 8 1 2 7.9 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1016/j.bmcl.2018.10.036
CHEMBL1644978 57086 None 0 Human Binding pKi = 6.3 6.3 -2 17
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assay
ChEMBL 537 8 1 2 7.9 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1016/j.bmcl.2018.10.036
44415689 139196 None 0 Human Binding pKi = 7.3 7.3 -58 6
Binding affinity at dopamine D5 receptorBinding affinity at dopamine D5 receptor
ChEMBL 494 2 2 6 4.7 CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(N)cccc3Cl)c3ccccc32)CC1 10.1016/j.bmcl.2006.06.022
CHEMBL378669 139196 None 0 Human Binding pKi = 7.3 7.3 -58 6
Binding affinity at dopamine D5 receptorBinding affinity at dopamine D5 receptor
ChEMBL 494 2 2 6 4.7 CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(N)cccc3Cl)c3ccccc32)CC1 10.1016/j.bmcl.2006.06.022
17756102 86178 None 0 Human Binding pKi = 7.3 7.3 -2 5
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 309 1 0 2 4.1 COc1ccc2c(c1)CCCN(C)CCCc1ccccc1C2 10.1021/jm070388+
CHEMBL231171 86178 None 0 Human Binding pKi = 7.3 7.3 -2 5
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 309 1 0 2 4.1 COc1ccc2c(c1)CCCN(C)CCCc1ccccc1C2 10.1021/jm070388+
44408818 140252 None 0 Human Binding pKi = 7.3 7.3 -12 6
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 281 1 0 2 3.3 COc1ccc2c(c1)CCN(C)CCc1ccccc1C2 10.1021/jm070388+
CHEMBL380330 140252 None 0 Human Binding pKi = 7.3 7.3 -12 6
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 281 1 0 2 3.3 COc1ccc2c(c1)CCN(C)CCc1ccccc1C2 10.1021/jm070388+
44408818 140252 None 0 Human Binding pKi = 7.3 7.3 -12 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 281 1 0 2 3.3 COc1ccc2c(c1)CCN(C)CCc1ccccc1C2 10.1016/j.bmc.2009.08.028
CHEMBL380330 140252 None 0 Human Binding pKi = 7.3 7.3 -12 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 281 1 0 2 3.3 COc1ccc2c(c1)CCN(C)CCc1ccccc1C2 10.1016/j.bmc.2009.08.028
11441173 13965 None 0 Human Binding pKi = 4.3 4.3 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 327 6 1 2 4.7 CCCN(CCC)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1196699 13965 None 0 Human Binding pKi = 4.3 4.3 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 327 6 1 2 4.7 CCCN(CCC)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL557840 13965 None 0 Human Binding pKi = 4.3 4.3 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 327 6 1 2 4.7 CCCN(CCC)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
17755999 142972 None 0 Human Binding pKi = 7.3 7.3 -9 6
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 295 1 0 2 3.7 COc1ccc2c(c1)CCCN(C)CCc1ccccc1C2 10.1021/jm070388+
CHEMBL389357 142972 None 0 Human Binding pKi = 7.3 7.3 -9 6
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 295 1 0 2 3.7 COc1ccc2c(c1)CCCN(C)CCc1ccccc1C2 10.1021/jm070388+
154725813 176631 None 1 Human Binding pKi = 5.3 5.3 -213 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 475 12 1 3 6.4 CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1 10.1021/acs.jmedchem.9b01835
CHEMBL4568916 176631 None 1 Human Binding pKi = 5.3 5.3 -213 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 475 12 1 3 6.4 CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1 10.1021/acs.jmedchem.9b01835
CHEMBL4597047 176631 None 1 Human Binding pKi = 5.3 5.3 -213 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 475 12 1 3 6.4 CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1 10.1021/acs.jmedchem.9b01835
137643132 158142 None 0 Human Binding pKi = 5.2 5.2 -4786 6
Displacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranes
ChEMBL 503 7 1 7 3.8 CC(C)(C)c1nc(N2CCN(CCCCNC(=O)c3cc4ccccn4n3)CC2)cc(C(F)(F)F)n1 10.1016/j.bmc.2017.04.036
CHEMBL4085920 158142 None 0 Human Binding pKi = 5.2 5.2 -4786 6
Displacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranes
ChEMBL 503 7 1 7 3.8 CC(C)(C)c1nc(N2CCN(CCCCNC(=O)c3cc4ccccn4n3)CC2)cc(C(F)(F)F)n1 10.1016/j.bmc.2017.04.036
154703541 176404 None 1 Human Binding pKi = 6.2 6.2 -24 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 464 11 1 3 6.1 CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC 10.1021/acs.jmedchem.9b01835
CHEMBL4541924 176404 None 1 Human Binding pKi = 6.2 6.2 -24 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 464 11 1 3 6.1 CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC 10.1021/acs.jmedchem.9b01835
CHEMBL4595195 176404 None 1 Human Binding pKi = 6.2 6.2 -24 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 464 11 1 3 6.1 CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC 10.1021/acs.jmedchem.9b01835
21509921 104514 None 0 Human Binding pKi = 6.2 6.2 -56 24
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 288 0 0 2 3.7 CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 10.1016/j.bmcl.2013.12.024
CHEMBL3104091 104514 None 0 Human Binding pKi = 6.2 6.2 -56 24
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 288 0 0 2 3.7 CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 10.1016/j.bmcl.2013.12.024
154705296 176499 None 1 Human Binding pKi = 5.2 5.2 -134 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 482 11 1 2 6.9 CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(C(F)(F)F)cc1 10.1021/acs.jmedchem.9b01835
CHEMBL4444691 176499 None 1 Human Binding pKi = 5.2 5.2 -134 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 482 11 1 2 6.9 CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(C(F)(F)F)cc1 10.1021/acs.jmedchem.9b01835
CHEMBL4595970 176499 None 1 Human Binding pKi = 5.2 5.2 -134 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 482 11 1 2 6.9 CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(C(F)(F)F)cc1 10.1021/acs.jmedchem.9b01835
44415704 80190 None 0 Human Binding pKi = 7.2 7.2 -19 6
Binding affinity at dopamine D5 receptorBinding affinity at dopamine D5 receptor
ChEMBL 474 2 2 6 4.4 Cc1cccc(N)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21 10.1016/j.bmcl.2006.06.022
CHEMBL213424 80190 None 0 Human Binding pKi = 7.2 7.2 -19 6
Binding affinity at dopamine D5 receptorBinding affinity at dopamine D5 receptor
ChEMBL 474 2 2 6 4.4 Cc1cccc(N)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21 10.1016/j.bmcl.2006.06.022
1353 1911 None 63 Human Binding pKi = 7.2 7.2 -54 85
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm049720x
3559 1911 None 63 Human Binding pKi = 7.2 7.2 -54 85
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm049720x
3559.0 1911 None 63 Human Binding pKi = 7.2 7.2 -54 85
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm049720x
86 1911 None 63 Human Binding pKi = 7.2 7.2 -54 85
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm049720x
CHEMBL54 1911 None 63 Human Binding pKi = 7.2 7.2 -54 85
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm049720x
DB00502 1911 None 63 Human Binding pKi = 7.2 7.2 -54 85
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm049720x
137635685 156096 None 0 Human Binding pKi = 5.2 5.2 -199 6
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 417 7 1 7 3.6 Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2cccnc12 10.1021/acs.jmedchem.7b00363
CHEMBL4061986 156096 None 0 Human Binding pKi = 5.2 5.2 -199 6
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 417 7 1 7 3.6 Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2cccnc12 10.1021/acs.jmedchem.7b00363
21509921 104514 None 0 Human Binding pKi = 6.2 6.2 -56 24
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 288 0 0 2 3.7 CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 10.1016/j.bmcl.2013.12.024
CHEMBL3104091 104514 None 0 Human Binding pKi = 6.2 6.2 -56 24
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 288 0 0 2 3.7 CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 10.1016/j.bmcl.2013.12.024
154704705 176430 None 1 Human Binding pKi = 6.2 6.2 -2 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 440 11 1 6 4.9 CCOc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C 10.1021/acs.jmedchem.9b01835
CHEMBL4590356 176430 None 1 Human Binding pKi = 6.2 6.2 -2 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 440 11 1 6 4.9 CCOc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C 10.1021/acs.jmedchem.9b01835
CHEMBL4595409 176430 None 1 Human Binding pKi = 6.2 6.2 -2 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 440 11 1 6 4.9 CCOc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C 10.1021/acs.jmedchem.9b01835
11121216 30147 None 0 Human Binding pKi = 6.2 6.2 -295 14
Binding affinity towards Dopamine receptor D5Binding affinity towards Dopamine receptor D5
ChEMBL 335 1 1 2 3.0 C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 10.1021/jm020153s
CHEMBL138989 30147 None 0 Human Binding pKi = 6.2 6.2 -295 14
Binding affinity towards Dopamine receptor D5Binding affinity towards Dopamine receptor D5
ChEMBL 335 1 1 2 3.0 C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 10.1021/jm020153s
11198948 13720 None 0 Human Binding pKi = 5.2 5.2 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 271 2 1 2 3.2 CN(C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1194996 13720 None 0 Human Binding pKi = 5.2 5.2 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 271 2 1 2 3.2 CN(C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL553690 13720 None 0 Human Binding pKi = 5.2 5.2 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 271 2 1 2 3.2 CN(C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
46232066 203713 None 0 Human Binding pKi = 8.2 8.2 -8 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 419 2 1 3 5.7 COc1ccc(-c2cccc3c2CC[C@H]2[C@H]3c3cc(O)c(Cl)cc3CCN2C)cc1 10.1016/j.bmcl.2009.12.094
CHEMBL603872 203713 None 0 Human Binding pKi = 8.2 8.2 -8 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 419 2 1 3 5.7 COc1ccc(-c2cccc3c2CC[C@H]2[C@H]3c3cc(O)c(Cl)cc3CCN2C)cc1 10.1016/j.bmcl.2009.12.094
171347340 194310 None 0 Human Binding pKi = 6.2 6.2 - 1
Binding affinity to dopamine 5 receptor (unknown origin)Binding affinity to dopamine 5 receptor (unknown origin)
ChEMBL 375 2 1 4 3.5 O=[N+]([O-])C1=Cc2cc(C#Cc3ccc(CO)cc3)ccc2OC1C(F)(F)F 10.1016/j.bmcl.2022.128981
CHEMBL5283362 194310 None 0 Human Binding pKi = 6.2 6.2 - 1
Binding affinity to dopamine 5 receptor (unknown origin)Binding affinity to dopamine 5 receptor (unknown origin)
ChEMBL 375 2 1 4 3.5 O=[N+]([O-])C1=Cc2cc(C#Cc3ccc(CO)cc3)ccc2OC1C(F)(F)F 10.1016/j.bmcl.2022.128981
145970938 165251 None 0 Human Binding pKi = 6.2 6.2 -4 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 233 5 1 2 3.4 CCCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
CHEMBL4228054 165251 None 0 Human Binding pKi = 6.2 6.2 -4 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 233 5 1 2 3.4 CCCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
154705884 176468 None 1 Human Binding pKi = 5.2 5.2 -190 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 448 11 1 2 6.5 CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01835
CHEMBL4469584 176468 None 1 Human Binding pKi = 5.2 5.2 -190 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 448 11 1 2 6.5 CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01835
CHEMBL4595726 176468 None 1 Human Binding pKi = 5.2 5.2 -190 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 448 11 1 2 6.5 CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01835
56597938 3940 None 4 Human Binding pKi = 6.2 6.2 -1380 9
Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.
ChEMBL 461 7 1 4 5.2 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl nan
7651 3940 None 4 Human Binding pKi = 6.2 6.2 -1380 9
Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.
ChEMBL 461 7 1 4 5.2 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl nan
CHEMBL2165126 3940 None 4 Human Binding pKi = 6.2 6.2 -1380 9
Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.
ChEMBL 461 7 1 4 5.2 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl nan
21171 187082 None 25 Human Binding pKi = 7.2 7.2 -1 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hr
ChEMBL 339 2 0 5 3.1 COc1ccc2c(c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4 10.1016/j.bmcl.2017.01.090
CHEMBL490533 187082 None 25 Human Binding pKi = 7.2 7.2 -1 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hr
ChEMBL 339 2 0 5 3.1 COc1ccc2c(c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4 10.1016/j.bmcl.2017.01.090
11406143 66153 None 0 Human Binding pKi = 6.2 6.2 2 4
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 372 7 0 3 4.5 c1ccc(Cc2ccccc2OCCN2CCN(c3ccccc3)CC2)cc1 10.1021/jm049720x
CHEMBL184073 66153 None 0 Human Binding pKi = 6.2 6.2 2 4
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 372 7 0 3 4.5 c1ccc(Cc2ccccc2OCCN2CCN(c3ccccc3)CC2)cc1 10.1021/jm049720x
145986752 167372 None 0 Human Binding pKi = 6.2 6.2 -1 17
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assay
ChEMBL 562 10 1 5 7.3 COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1 10.1016/j.bmcl.2018.10.036
CHEMBL4293307 167372 None 0 Human Binding pKi = 6.2 6.2 -1 17
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assay
ChEMBL 562 10 1 5 7.3 COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1 10.1016/j.bmcl.2018.10.036
3038495 708 None 33 Rat Binding pKi = 6.2 6.2 -407 27
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 417 8 1 4 4.2 COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 10.1021/jm049031l
7625 708 None 33 Rat Binding pKi = 6.2 6.2 -407 27
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 417 8 1 4 4.2 COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 10.1021/jm049031l
CHEMBL25236 708 None 33 Rat Binding pKi = 6.2 6.2 -407 27
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 417 8 1 4 4.2 COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 10.1021/jm049031l
145969667 165060 None 0 Human Binding pKi = 6.2 6.2 -41 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 289 9 1 2 4.9 CCCCCCCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
CHEMBL4225278 165060 None 0 Human Binding pKi = 6.2 6.2 -41 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 289 9 1 2 4.9 CCCCCCCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
145967904 165192 None 0 Human Binding pKi = 6.2 6.2 -5 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 247 6 1 2 3.8 CCCCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
CHEMBL4227192 165192 None 0 Human Binding pKi = 6.2 6.2 -5 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 247 6 1 2 3.8 CCCCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
56594402 70623 None 0 Human Binding pKi = 6.2 6.2 - 1
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cells
ChEMBL 334 1 2 2 3.2 CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1C(=O)O 10.1021/jm200676f
CHEMBL1949727 70623 None 0 Human Binding pKi = 6.2 6.2 - 1
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cells
ChEMBL 334 1 2 2 3.2 CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1C(=O)O 10.1021/jm200676f
70607606 177309 None 0 Human Binding pKi = 7.2 7.2 -2 2
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 333 1 3 3 3.1 Oc1cc2c(cc1O)C(c1ccccc1Br)CNCC2 10.1016/j.bmcl.2020.127305
CHEMBL4635277 177309 None 0 Human Binding pKi = 7.2 7.2 -2 2
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 333 1 3 3 3.1 Oc1cc2c(cc1O)C(c1ccccc1Br)CNCC2 10.1016/j.bmcl.2020.127305
11247757 133648 None 0 Rat Binding pKi = 5.2 5.2 -741 3
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 443 7 1 4 4.5 COc1cccc2c1CC[C@H]1CN(CCCCNC(=O)c3ccc4ccccc4c3)CCN21 10.1021/jm049031l
CHEMBL371200 133648 None 0 Rat Binding pKi = 5.2 5.2 -741 3
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 443 7 1 4 4.5 COc1cccc2c1CC[C@H]1CN(CCCCNC(=O)c3ccc4ccccc4c3)CCN21 10.1021/jm049031l
17756213 149792 None 0 Human Binding pKi = 7.2 7.2 -1 5
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 281 0 1 2 3.4 CN1CCCc2ccccc2Cc2cc(O)ccc2CC1 10.1021/jm070388+
CHEMBL394779 149792 None 0 Human Binding pKi = 7.2 7.2 -1 5
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 281 0 1 2 3.4 CN1CCCc2ccccc2Cc2cc(O)ccc2CC1 10.1021/jm070388+
44415672 80205 None 0 Human Binding pKi = 8.2 8.2 -5 6
Binding affinity at dopamine D5 receptorBinding affinity at dopamine D5 receptor
ChEMBL 531 2 1 5 5.6 CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(F)cccc3C(F)(F)F)c3ccccc32)CC1 10.1016/j.bmcl.2006.06.022
CHEMBL213492 80205 None 0 Human Binding pKi = 8.2 8.2 -5 6
Binding affinity at dopamine D5 receptorBinding affinity at dopamine D5 receptor
ChEMBL 531 2 1 5 5.6 CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(F)cccc3C(F)(F)F)c3ccccc32)CC1 10.1016/j.bmcl.2006.06.022
46231768 201936 None 0 Human Binding pKi = 8.2 8.2 -2 3
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 328 0 2 3 3.6 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(N)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.100
CHEMBL591685 201936 None 0 Human Binding pKi = 8.2 8.2 -2 3
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 328 0 2 3 3.6 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(N)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.100
25142456 82438 None 1 Human Binding pKi = 8.2 8.2 -3 9
Binding affinity to human cloned dopamine D5 receptorBinding affinity to human cloned dopamine D5 receptor
ChEMBL 269 0 3 4 2.1 Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2 10.1021/jm0604979
CHEMBL217299 82438 None 1 Human Binding pKi = 8.2 8.2 -3 9
Binding affinity to human cloned dopamine D5 receptorBinding affinity to human cloned dopamine D5 receptor
ChEMBL 269 0 3 4 2.1 Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2 10.1021/jm0604979
11223303 203286 None 0 Human Binding pKi = 8.2 8.2 -4 3
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 399 2 3 3 4.1 CCNC(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C 10.1016/j.bmcl.2009.12.100
CHEMBL600987 203286 None 0 Human Binding pKi = 8.2 8.2 -4 3
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 399 2 3 3 4.1 CCNC(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C 10.1016/j.bmcl.2009.12.100
46231847 203030 None 0 Human Binding pKi = 8.1 8.1 -3 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 343 1 2 3 3.5 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(CO)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
CHEMBL599116 203030 None 0 Human Binding pKi = 8.1 8.1 -3 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 343 1 2 3 3.5 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(CO)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
4350931 169416 None 30 Human Binding pKi = 8.1 8.1 -123 7
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 290 0 1 1 3.8 CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm051237e
CHEMBL441618 169416 None 30 Human Binding pKi = 8.1 8.1 -123 7
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 290 0 1 1 3.8 CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm051237e
4350931 169416 None 30 Human Binding pKi = 8.1 8.1 -123 7
Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay
ChEMBL 290 0 1 1 3.8 CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1039/C5MD00258C
CHEMBL441618 169416 None 30 Human Binding pKi = 8.1 8.1 -123 7
Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay
ChEMBL 290 0 1 1 3.8 CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1039/C5MD00258C
4350931 169416 None 30 Human Binding pKi = 8.1 8.1 -123 7
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 290 0 1 1 3.8 CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1016/j.bmcl.2006.11.093
CHEMBL441618 169416 None 30 Human Binding pKi = 8.1 8.1 -123 7
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 290 0 1 1 3.8 CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1016/j.bmcl.2006.11.093
4350931 169416 None 30 Human Binding pKi = 8.1 8.1 -123 7
Displacement of [3H]SCH 23390 from human D5 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D5 dopamine receptor expressed in HEK293 cells
ChEMBL 290 0 1 1 3.8 CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm060213k
CHEMBL441618 169416 None 30 Human Binding pKi = 8.1 8.1 -123 7
Displacement of [3H]SCH 23390 from human D5 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D5 dopamine receptor expressed in HEK293 cells
ChEMBL 290 0 1 1 3.8 CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm060213k
46231845 203189 None 0 Human Binding pKi = 8.1 8.1 -2 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 391 0 1 2 4.7 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(Br)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
CHEMBL600083 203189 None 0 Human Binding pKi = 8.1 8.1 -2 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 391 0 1 2 4.7 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(Br)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
122177645 121277 None 0 Human Binding pKi = 6.2 6.2 -3311 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis
ChEMBL 591 18 2 8 5.6 CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@H]3CCc4c(O)cccc4C3)cc2OC)nn1 10.1021/jm501889t
CHEMBL3577346 121277 None 0 Human Binding pKi = 6.2 6.2 -3311 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis
ChEMBL 591 18 2 8 5.6 CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@H]3CCc4c(O)cccc4C3)cc2OC)nn1 10.1021/jm501889t
122181330 121937 None 0 Human Binding pKi = 5.2 5.2 -8128 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranes
ChEMBL 396 9 1 3 5.3 CCCN(CCCCNC(=O)/N=N/c1ccc(F)cc1)C1Cc2ccccc2C1 10.1016/j.bmc.2014.12.012
CHEMBL3590081 121937 None 0 Human Binding pKi = 5.2 5.2 -8128 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranes
ChEMBL 396 9 1 3 5.3 CCCN(CCCCNC(=O)/N=N/c1ccc(F)cc1)C1Cc2ccccc2C1 10.1016/j.bmc.2014.12.012
22475020 96056 None 19 Human Binding pKi = 6.2 6.2 -234 8
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 491 3 0 4 5.4 O=C(c1cc2c(cc1F)OC(c1ccc(F)cc1)(c1ccc(Cl)cc1Cl)O2)N1CCOCC1 10.6019/CHEMBL5442175
CHEMBL259656 96056 None 19 Human Binding pKi = 6.2 6.2 -234 8
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 491 3 0 4 5.4 O=C(c1cc2c(cc1F)OC(c1ccc(F)cc1)(c1ccc(Cl)cc1Cl)O2)N1CCOCC1 10.6019/CHEMBL5442175
11301268 13980 None 0 Human Binding pKi = 4.2 4.2 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 271 3 1 2 3.1 CN[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1196825 13980 None 0 Human Binding pKi = 4.2 4.2 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 271 3 1 2 3.1 CN[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL558364 13980 None 0 Human Binding pKi = 4.2 4.2 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 271 3 1 2 3.1 CN[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
11290688 13949 None 0 Human Binding pKi = 5.1 5.1 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 257 2 2 2 2.8 CN[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1196599 13949 None 0 Human Binding pKi = 5.1 5.1 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 257 2 2 2 2.8 CN[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL557582 13949 None 0 Human Binding pKi = 5.1 5.1 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 257 2 2 2 2.8 CN[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
16007117 80067 None 0 Human Binding pKi = 7.1 7.1 -72 6
Binding affinity at dopamine D5 receptorBinding affinity at dopamine D5 receptor
ChEMBL 479 2 1 5 5.1 CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1 10.1016/j.bmcl.2006.06.022
CHEMBL212912 80067 None 0 Human Binding pKi = 7.1 7.1 -72 6
Binding affinity at dopamine D5 receptorBinding affinity at dopamine D5 receptor
ChEMBL 479 2 1 5 5.1 CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1 10.1016/j.bmcl.2006.06.022
44582676 189888 None 0 Human Binding pKi = 5.1 5.1 -57 17
Inhibition of human cloned dopamine D5 receptor by competitive binding experimentInhibition of human cloned dopamine D5 receptor by competitive binding experiment
ChEMBL 403 9 0 4 4.3 COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 10.1016/j.bmc.2009.03.021
CHEMBL516088 189888 None 0 Human Binding pKi = 5.1 5.1 -57 17
Inhibition of human cloned dopamine D5 receptor by competitive binding experimentInhibition of human cloned dopamine D5 receptor by competitive binding experiment
ChEMBL 403 9 0 4 4.3 COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 10.1016/j.bmc.2009.03.021
44582675 189810 None 0 Human Binding pKi = 5.1 5.1 -125 15
Inhibition of human cloned dopamine D5 receptor by competitive binding experimentInhibition of human cloned dopamine D5 receptor by competitive binding experiment
ChEMBL 405 9 1 4 4.2 COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1 10.1016/j.bmc.2009.03.021
CHEMBL515472 189810 None 0 Human Binding pKi = 5.1 5.1 -125 15
Inhibition of human cloned dopamine D5 receptor by competitive binding experimentInhibition of human cloned dopamine D5 receptor by competitive binding experiment
ChEMBL 405 9 1 4 4.2 COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1 10.1016/j.bmc.2009.03.021
145980271 166587 None 0 Human Binding pKi = 6.1 6.1 -1 16
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assay
ChEMBL 538 8 1 3 7.5 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1016/j.bmcl.2018.10.036
CHEMBL4278465 166587 None 0 Human Binding pKi = 6.1 6.1 -1 16
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assay
ChEMBL 538 8 1 3 7.5 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1016/j.bmcl.2018.10.036
17756212 86402 None 0 Human Binding pKi = 7.1 7.1 1 5
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 295 1 0 2 3.7 COc1ccc2c(c1)Cc1ccccc1CCCN(C)CC2 10.1021/jm070388+
CHEMBL231374 86402 None 0 Human Binding pKi = 7.1 7.1 1 5
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 295 1 0 2 3.7 COc1ccc2c(c1)Cc1ccccc1CCCN(C)CC2 10.1021/jm070388+
42626289 148167 None 0 Human Binding pKi = 7.1 7.1 -3 4
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 379 7 0 4 3.3 COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1 10.1016/j.bmc.2007.06.002
CHEMBL393492 148167 None 0 Human Binding pKi = 7.1 7.1 -3 4
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 379 7 0 4 3.3 COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1 10.1016/j.bmc.2007.06.002
11442138 69211 None 0 Rat Binding pKi = 5.1 5.1 -1862 3
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 443 7 1 4 4.5 COc1cccc2c1N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@H]1CC2 10.1021/jm049031l
CHEMBL192650 69211 None 0 Rat Binding pKi = 5.1 5.1 -1862 3
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 443 7 1 4 4.5 COc1cccc2c1N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@H]1CC2 10.1021/jm049031l
11415988 13973 None 0 Human Binding pKi = 5.1 5.1 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 285 3 0 2 3.5 COc1cc2c(cc1F)[C@@H](c1ccccc1)[C@H](N(C)C)C2 10.1021/jm040889k
CHEMBL1196757 13973 None 0 Human Binding pKi = 5.1 5.1 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 285 3 0 2 3.5 COc1cc2c(cc1F)[C@@H](c1ccccc1)[C@H](N(C)C)C2 10.1021/jm040889k
CHEMBL558040 13973 None 0 Human Binding pKi = 5.1 5.1 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 285 3 0 2 3.5 COc1cc2c(cc1F)[C@@H](c1ccccc1)[C@H](N(C)C)C2 10.1021/jm040889k
137651322 157567 None 0 Human Binding pKi = 5.1 5.1 -8709 6
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes
ChEMBL 465 8 2 9 2.2 O=Cc1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc12 10.1016/j.bmc.2017.08.037
CHEMBL4079375 157567 None 0 Human Binding pKi = 5.1 5.1 -8709 6
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes
ChEMBL 465 8 2 9 2.2 O=Cc1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc12 10.1016/j.bmc.2017.08.037
11405458 12773 None 0 Human Binding pKi = 5.1 5.1 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 271 2 1 2 3.2 CN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1187931 12773 None 0 Human Binding pKi = 5.1 5.1 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 271 2 1 2 3.2 CN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL534478 12773 None 0 Human Binding pKi = 5.1 5.1 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 271 2 1 2 3.2 CN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
154706461 176453 None 1 Human Binding pKi = 5.1 5.1 -331 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 509 12 1 3 6.8 CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(C(F)(F)F)cc1 10.1021/acs.jmedchem.9b01835
CHEMBL4470439 176453 None 1 Human Binding pKi = 5.1 5.1 -331 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 509 12 1 3 6.8 CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(C(F)(F)F)cc1 10.1021/acs.jmedchem.9b01835
CHEMBL4595600 176453 None 1 Human Binding pKi = 5.1 5.1 -331 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 509 12 1 3 6.8 CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(C(F)(F)F)cc1 10.1021/acs.jmedchem.9b01835
135398737 958 None 57 Human Binding pKi = 6.1 6.1 -89 91
Compound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm9601720
135398737.0 958 None 57 Human Binding pKi = 6.1 6.1 -89 91
Compound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm9601720
38 958 None 57 Human Binding pKi = 6.1 6.1 -89 91
Compound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm9601720
722 958 None 57 Human Binding pKi = 6.1 6.1 -89 91
Compound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm9601720
CHEMBL42 958 None 57 Human Binding pKi = 6.1 6.1 -89 91
Compound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm9601720
DB00363 958 None 57 Human Binding pKi = 6.1 6.1 -89 91
Compound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1021/jm9601720
154706431 176690 None 1 Human Binding pKi = 6.1 6.1 -70 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 451 12 2 3 5.3 CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC 10.1021/acs.jmedchem.9b01835
CHEMBL4531363 176690 None 1 Human Binding pKi = 6.1 6.1 -70 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 451 12 2 3 5.3 CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC 10.1021/acs.jmedchem.9b01835
CHEMBL4597531 176690 None 1 Human Binding pKi = 6.1 6.1 -70 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 451 12 2 3 5.3 CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC 10.1021/acs.jmedchem.9b01835
11637457 73112 None 0 Human Binding pKi = 7.1 7.1 -1 5
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 257 0 0 2 3.4 CN1CCc2ccccc2Cc2ccsc2CC1 10.1021/jm050846j
CHEMBL201093 73112 None 0 Human Binding pKi = 7.1 7.1 -1 5
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 257 0 0 2 3.4 CN1CCc2ccccc2Cc2ccsc2CC1 10.1021/jm050846j
11154555 800 None 50 Human Binding pKi = 5.1 5.1 -724 24
Displacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranes
ChEMBL 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2017.04.036
11154555.0 800 None 50 Human Binding pKi = 5.1 5.1 -724 24
Displacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranes
ChEMBL 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2017.04.036
5037 800 None 50 Human Binding pKi = 5.1 5.1 -724 24
Displacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranes
ChEMBL 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2017.04.036
7671 800 None 50 Human Binding pKi = 5.1 5.1 -724 24
Displacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranes
ChEMBL 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2017.04.036
CHEMBL2028019 800 None 50 Human Binding pKi = 5.1 5.1 -724 24
Displacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranes
ChEMBL 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2017.04.036
CHEMBL3085826 800 None 50 Human Binding pKi = 5.1 5.1 -724 24
Displacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranes
ChEMBL 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2017.04.036
DB06016 800 None 50 Human Binding pKi = 5.1 5.1 -724 24
Displacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranes
ChEMBL 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2017.04.036
9801858 63466 None 0 Rat Binding pKi = 6.1 6.1 -12 3
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 413 6 1 3 4.5 O=C(NCCCCN1CCN2c3ccccc3CCC2C1)c1ccc2ccccc2c1 10.1021/jm049031l
CHEMBL179757 63466 None 0 Rat Binding pKi = 6.1 6.1 -12 3
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 413 6 1 3 4.5 O=C(NCCCCN1CCN2c3ccccc3CCC2C1)c1ccc2ccccc2c1 10.1021/jm049031l
3036864 205211 None 16 Human Binding pKi = 8.1 8.1 -3 27
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1021/jm040889k
CHEMBL1256645 205211 None 16 Human Binding pKi = 8.1 8.1 -3 27
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1021/jm040889k
CHEMBL1814790 205211 None 16 Human Binding pKi = 8.1 8.1 -3 27
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1021/jm040889k
CHEMBL62 205211 None 16 Human Binding pKi = 8.1 8.1 -3 27
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1021/jm040889k
46231646 202921 None 0 Human Binding pKi = 8.1 8.1 -1 3
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 328 0 2 3 3.6 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(N)cc3CC[C@@H]21 10.1016/j.bmcl.2009.12.100
CHEMBL598515 202921 None 0 Human Binding pKi = 8.1 8.1 -1 3
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 328 0 2 3 3.6 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(N)cc3CC[C@@H]21 10.1016/j.bmcl.2009.12.100
42625354 91634 None 0 Human Binding pKi = 7.1 7.1 -2 4
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 349 6 0 3 3.2 O=C1c2ccccc2CN1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2007.06.002
CHEMBL240774 91634 None 0 Human Binding pKi = 7.1 7.1 -2 4
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 349 6 0 3 3.2 O=C1c2ccccc2CN1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2007.06.002
44436308 91793 None 0 Human Binding pKi = 7.1 7.1 -5 3
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 417 6 0 3 4.3 O=C1c2ccccc2CN1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2007.06.002
CHEMBL240996 91793 None 0 Human Binding pKi = 7.1 7.1 -5 3
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 417 6 0 3 4.3 O=C1c2ccccc2CN1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2007.06.002
154705038 176751 None 1 Human Binding pKi = 5.1 5.1 -245 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 471 11 2 2 6.2 CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(C(F)(F)F)cc1 10.1021/acs.jmedchem.9b01835
CHEMBL4584481 176751 None 1 Human Binding pKi = 5.1 5.1 -245 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 471 11 2 2 6.2 CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(C(F)(F)F)cc1 10.1021/acs.jmedchem.9b01835
CHEMBL4598001 176751 None 1 Human Binding pKi = 5.1 5.1 -245 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 471 11 2 2 6.2 CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(C(F)(F)F)cc1 10.1021/acs.jmedchem.9b01835
130442480 175374 None 0 Human Binding pKi = 7.1 7.1 1 24
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method
ChEMBL 410 3 0 6 5.7 Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F 10.1021/acs.jmedchem.9b00351
CHEMBL4572614 175374 None 0 Human Binding pKi = 7.1 7.1 1 24
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method
ChEMBL 410 3 0 6 5.7 Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F 10.1021/acs.jmedchem.9b00351
156011458 177409 None 0 Human Binding pKi = 7.1 7.1 -1 2
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 347 2 2 3 3.4 COc1cc2c(cc1O)C(c1ccccc1Br)CNCC2 10.1016/j.bmcl.2020.127305
CHEMBL4636741 177409 None 0 Human Binding pKi = 7.1 7.1 -1 2
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 347 2 2 3 3.4 COc1cc2c(cc1O)C(c1ccccc1Br)CNCC2 10.1016/j.bmcl.2020.127305
11290269 13766 None 0 Human Binding pKi = 5.1 5.1 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 243 1 2 2 2.5 N[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1195331 13766 None 0 Human Binding pKi = 5.1 5.1 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 243 1 2 2 2.5 N[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL554303 13766 None 0 Human Binding pKi = 5.1 5.1 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 243 1 2 2 2.5 N[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
11153135 12821 None 0 Human Binding pKi = 4.1 4.1 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 341 7 0 2 5.0 CCCN(CCC)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1188308 12821 None 0 Human Binding pKi = 4.1 4.1 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 341 7 0 2 5.0 CCCN(CCC)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL536044 12821 None 0 Human Binding pKi = 4.1 4.1 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 341 7 0 2 5.0 CCCN(CCC)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
71062708 154395 None 0 Mouse Binding pKi = 5.1 5.1 -48 12
Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.
ChEMBL 368 7 0 5 2.8 COc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1 nan
CHEMBL3986651 154395 None 0 Mouse Binding pKi = 5.1 5.1 -48 12
Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.
ChEMBL 368 7 0 5 2.8 COc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1 nan
57398351 70182 None 0 Human Binding pKi = 6.1 6.1 -91 7
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 347 6 0 2 5.1 Fc1ccc(OCCCN2CCC(c3ccc(Cl)cc3)CC2)cc1 10.1016/j.bmc.2014.04.026
CHEMBL1940406 70182 None 0 Human Binding pKi = 6.1 6.1 -91 7
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 347 6 0 2 5.1 Fc1ccc(OCCCN2CCC(c3ccc(Cl)cc3)CC2)cc1 10.1016/j.bmc.2014.04.026
154725001 176752 None 1 Human Binding pKi = 5.1 5.1 -562 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 448 11 1 2 6.5 CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1 10.1021/acs.jmedchem.9b01835
CHEMBL4525624 176752 None 1 Human Binding pKi = 5.1 5.1 -562 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 448 11 1 2 6.5 CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1 10.1021/acs.jmedchem.9b01835
CHEMBL4598002 176752 None 1 Human Binding pKi = 5.1 5.1 -562 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 448 11 1 2 6.5 CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1 10.1021/acs.jmedchem.9b01835
154724650 176442 None 1 Human Binding pKi = 5.1 5.1 -501 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 475 12 1 3 6.4 CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01835
CHEMBL4543870 176442 None 1 Human Binding pKi = 5.1 5.1 -501 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 475 12 1 3 6.4 CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01835
CHEMBL4595492 176442 None 1 Human Binding pKi = 5.1 5.1 -501 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 475 12 1 3 6.4 CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01835
11439190 203762 None 0 Human Binding pKi = 7.1 7.1 -31 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 338 0 1 3 3.9 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C#N)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
CHEMBL604127 203762 None 0 Human Binding pKi = 7.1 7.1 -31 4
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 338 0 1 3 3.9 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C#N)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
11631304 73401 None 0 Human Binding pKi = 6.1 6.1 -1 2
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 330 2 1 1 4.6 c1ccc2c(c1)CCN(CC1CC1)CCc1c([nH]c3ccccc13)C2 10.1021/jm050846j
CHEMBL201432 73401 None 0 Human Binding pKi = 6.1 6.1 -1 2
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 330 2 1 1 4.6 c1ccc2c(c1)CCN(CC1CC1)CCc1c([nH]c3ccccc13)C2 10.1021/jm050846j
11976 920 None 44 Human Binding pKi = 8.1 8.1 -8 23
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1016/j.bmcl.2008.09.012
667467 920 None 44 Human Binding pKi = 8.1 8.1 -8 23
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1016/j.bmcl.2008.09.012
667467.0 920 None 44 Human Binding pKi = 8.1 8.1 -8 23
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1016/j.bmcl.2008.09.012
CHEMBL908 920 None 44 Human Binding pKi = 8.1 8.1 -8 23
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1016/j.bmcl.2008.09.012
DB01239 920 None 44 Human Binding pKi = 8.1 8.1 -8 23
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1016/j.bmcl.2008.09.012
440229 87545 None 34 Human Binding pKi = 8.0 8.0 -1 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cells after 1 hr
ChEMBL 341 3 1 5 3.1 COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2 10.1016/j.bmcl.2017.01.090
CHEMBL2334891 87545 None 34 Human Binding pKi = 8.0 8.0 -1 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cells after 1 hr
ChEMBL 341 3 1 5 3.1 COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2 10.1016/j.bmcl.2017.01.090
17755867 86143 None 0 Human Binding pKi = 8.0 8.0 -4 6
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 281 0 1 2 3.4 CN1CCCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm070388+
CHEMBL231070 86143 None 0 Human Binding pKi = 8.0 8.0 -4 6
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 281 0 1 2 3.4 CN1CCCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm070388+
135398745 2914 None 65 Human Binding pKi = 7.1 7.1 -26 65
Displacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1039/C5MD00258C
135398745.0 2914 None 65 Human Binding pKi = 7.1 7.1 -26 65
Displacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1039/C5MD00258C
47 2914 None 65 Human Binding pKi = 7.1 7.1 -26 65
Displacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1039/C5MD00258C
CHEMBL715 2914 None 65 Human Binding pKi = 7.1 7.1 -26 65
Displacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1039/C5MD00258C
DB00334 2914 None 65 Human Binding pKi = 7.1 7.1 -26 65
Displacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1039/C5MD00258C
11221294 12784 None 0 Human Binding pKi = 5.1 5.1 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 297 4 1 2 3.7 C=CCN(C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1187988 12784 None 0 Human Binding pKi = 5.1 5.1 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 297 4 1 2 3.7 C=CCN(C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL534706 12784 None 0 Human Binding pKi = 5.1 5.1 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 297 4 1 2 3.7 C=CCN(C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
182600 118808 None 1 Rat Binding pKi = 6.0 6.0 -10 4
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 352 5 0 3 3.9 O=C(CCCN1CCN2c3ccccc3CCC2C1)c1ccc(F)cc1 10.1021/jm049031l
CHEMBL341774 118808 None 1 Rat Binding pKi = 6.0 6.0 -10 4
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 352 5 0 3 3.9 O=C(CCCN1CCN2c3ccccc3CCC2C1)c1ccc(F)cc1 10.1021/jm049031l
56589561 70625 None 0 Human Binding pKi = 7.0 7.0 1 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cells
ChEMBL 320 1 2 2 3.2 CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@H]1CO 10.1021/jm200676f
CHEMBL1949729 70625 None 0 Human Binding pKi = 7.0 7.0 1 5
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cells
ChEMBL 320 1 2 2 3.2 CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@H]1CO 10.1021/jm200676f
16090821 81864 None 0 Human Binding pKi = 7.0 7.0 -21 6
Displacement of [3H]SCH 23390 from human D5 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D5 dopamine receptor expressed in HEK293 cells
ChEMBL 304 0 1 1 4.2 CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1 10.1021/jm060213k
CHEMBL216439 81864 None 0 Human Binding pKi = 7.0 7.0 -21 6
Displacement of [3H]SCH 23390 from human D5 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D5 dopamine receptor expressed in HEK293 cells
ChEMBL 304 0 1 1 4.2 CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1 10.1021/jm060213k
135986088 178220 None 0 Human Binding pKi = 6.0 6.0 -275 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 543 7 1 6 6.5 Clc1ccc2c(c1)N=C(N1CCN(Cc3ccc(OCCCN4CCCCC4)cc3)CC1)c1ccccc1N2 10.1016/j.bmcl.2008.09.012
CHEMBL464811 178220 None 0 Human Binding pKi = 6.0 6.0 -275 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 543 7 1 6 6.5 Clc1ccc2c(c1)N=C(N1CCN(Cc3ccc(OCCCN4CCCCC4)cc3)CC1)c1ccccc1N2 10.1016/j.bmcl.2008.09.012
154727713 176469 None 1 Human Binding pKi = 6.0 6.0 -10 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 426 10 1 6 4.5 COc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C 10.1021/acs.jmedchem.9b01835
CHEMBL4514586 176469 None 1 Human Binding pKi = 6.0 6.0 -10 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 426 10 1 6 4.5 COc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C 10.1021/acs.jmedchem.9b01835
CHEMBL4595727 176469 None 1 Human Binding pKi = 6.0 6.0 -10 5
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 426 10 1 6 4.5 COc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C 10.1021/acs.jmedchem.9b01835
154725277 176537 None 1 Human Binding pKi = 5.0 5.0 -363 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 437 11 2 2 5.8 CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01835
CHEMBL4472900 176537 None 1 Human Binding pKi = 5.0 5.0 -363 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 437 11 2 2 5.8 CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01835
CHEMBL4596220 176537 None 1 Human Binding pKi = 5.0 5.0 -363 6
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 437 11 2 2 5.8 CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01835
137645574 157895 None 0 Human Binding pKi = 5.0 5.0 -9999 6
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 462 7 3 6 3.1 O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2N1 10.1021/acs.jmedchem.7b00363
CHEMBL4083239 157895 None 0 Human Binding pKi = 5.0 5.0 -9999 6
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 462 7 3 6 3.1 O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2N1 10.1021/acs.jmedchem.7b00363
11698643 3630 None 12 Human Binding pKi = 6.0 6.0 -181 4
Binding affinity to human dopamine D5 receptorBinding affinity to human dopamine D5 receptor
ChEMBL 479 6 0 4 6.0 O=C1C(=Nc2cccc(c2)C(F)(F)F)c2c(N1c1cccc(c1)OCCN1CCCC1)cccc2 10.1016/j.bmcl.2006.05.025
6125 3630 None 12 Human Binding pKi = 6.0 6.0 -181 4
Binding affinity to human dopamine D5 receptorBinding affinity to human dopamine D5 receptor
ChEMBL 479 6 0 4 6.0 O=C1C(=Nc2cccc(c2)C(F)(F)F)c2c(N1c1cccc(c1)OCCN1CCCC1)cccc2 10.1016/j.bmcl.2006.05.025
CHEMBL209497 3630 None 12 Human Binding pKi = 6.0 6.0 -181 4
Binding affinity to human dopamine D5 receptorBinding affinity to human dopamine D5 receptor
ChEMBL 479 6 0 4 6.0 O=C1C(=Nc2cccc(c2)C(F)(F)F)c2c(N1c1cccc(c1)OCCN1CCCC1)cccc2 10.1016/j.bmcl.2006.05.025
17755868 143205 None 0 Human Binding pKi = 7.0 7.0 -1 5
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 295 0 1 2 3.8 CN1CCCc2ccccc2Cc2ccc(O)cc2CCC1 10.1021/jm070388+
CHEMBL389559 143205 None 0 Human Binding pKi = 7.0 7.0 -1 5
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 295 0 1 2 3.8 CN1CCCc2ccccc2Cc2ccc(O)cc2CCC1 10.1021/jm070388+
44396235 168640 None 0 Human Binding pKi = 6.0 6.0 -60 5
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 281 6 0 2 3.8 c1ccc(Cc2ccccc2OCCN2CCCC2)cc1 10.1021/jm049720x
CHEMBL435505 168640 None 0 Human Binding pKi = 6.0 6.0 -60 5
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 281 6 0 2 3.8 c1ccc(Cc2ccccc2OCCN2CCCC2)cc1 10.1021/jm049720x
145968810 165133 None 0 Human Binding pKi = 6.0 6.0 -33 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 381 8 2 4 3.5 CN(C)c1ccc(C(=O)NCCCCN2CCC(c3cccc(O)c3)C2)cc1 10.1016/j.bmcl.2018.03.084
CHEMBL4226226 165133 None 0 Human Binding pKi = 6.0 6.0 -33 6
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 381 8 2 4 3.5 CN(C)c1ccc(C(=O)NCCCCN2CCC(c3cccc(O)c3)C2)cc1 10.1016/j.bmcl.2018.03.084
11450584 12804 None 0 Human Binding pKi = 5.0 5.0 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 257 2 2 2 2.8 CN[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1188142 12804 None 0 Human Binding pKi = 5.0 5.0 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 257 2 2 2 2.8 CN[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL535374 12804 None 0 Human Binding pKi = 5.0 5.0 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 257 2 2 2 2.8 CN[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
11151473 13936 None 0 Human Binding pKi = 5.0 5.0 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 243 1 2 2 2.5 N[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1196485 13936 None 0 Human Binding pKi = 5.0 5.0 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 243 1 2 2 2.5 N[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL557171 13936 None 0 Human Binding pKi = 5.0 5.0 - 1
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 243 1 2 2 2.5 N[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
76328715 106428 None 0 Human Binding pKi = 5.0 5.0 -1047 4
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 429 9 2 6 2.8 Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(OCCF)cc3)CC1)CC2 10.1021/jm401384w
CHEMBL3115582 106428 None 0 Human Binding pKi = 5.0 5.0 -1047 4
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 429 9 2 6 2.8 Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(OCCF)cc3)CC1)CC2 10.1021/jm401384w
CHEMBL3139265 106428 None 0 Human Binding pKi = 5.0 5.0 -1047 4
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 429 9 2 6 2.8 Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(OCCF)cc3)CC1)CC2 10.1021/jm401384w
49783209 17616 None 0 Human Binding pKi = 6.0 6.0 -489 26
Binding affinity to human dopamine D5 receptorBinding affinity to human dopamine D5 receptor
ChEMBL 396 7 1 6 3.8 CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 10.1021/jm100668r
CHEMBL1258223 17616 None 0 Human Binding pKi = 6.0 6.0 -489 26
Binding affinity to human dopamine D5 receptorBinding affinity to human dopamine D5 receptor
ChEMBL 396 7 1 6 3.8 CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 10.1021/jm100668r
76328715 106428 None 0 Human Binding pKi = 5.0 5.0 -1047 4
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 429 9 2 6 2.8 Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(OCCF)cc3)CC1)CC2 10.1021/jm401384w
CHEMBL3115582 106428 None 0 Human Binding pKi = 5.0 5.0 -1047 4
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 429 9 2 6 2.8 Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(OCCF)cc3)CC1)CC2 10.1021/jm401384w
CHEMBL3139265 106428 None 0 Human Binding pKi = 5.0 5.0 -1047 4
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 429 9 2 6 2.8 Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(OCCF)cc3)CC1)CC2 10.1021/jm401384w
52936725 61270 None 22 Human Binding pKi = 6 6.0 -39810 13
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 432 6 2 4 6.3 Cc1cc(C)cc(-c2cnc3cc(Cl)c(-c4cccc(O)c4)cc3c2OCCCN)c1 10.6019/CHEMBL5442175
CHEMBL1766103 61270 None 22 Human Binding pKi = 6 6.0 -39810 13
PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
ChEMBL 432 6 2 4 6.3 Cc1cc(C)cc(-c2cnc3cc(Cl)c(-c4cccc(O)c4)cc3c2OCCCN)c1 10.6019/CHEMBL5442175
5018 3549 None 8 Human Binding pKd = 9.2 9.2 -2 9
UnclassifiedUnclassified
Guide to Pharmacology 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O 8051291
943 3549 None 8 Human Binding pKd = 9.2 9.2 -2 9
UnclassifiedUnclassified
Guide to Pharmacology 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O 8051291
946 3549 None 8 Human Binding pKd = 9.2 9.2 -2 9
UnclassifiedUnclassified
Guide to Pharmacology 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O 8051291
CHEMBL13668 3549 None 8 Human Binding pKd = 9.2 9.2 -2 9
UnclassifiedUnclassified
Guide to Pharmacology 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O 8051291
3036864 205211 3H-SCH23390 16 Human Binding pKi = 9.5 9.5 -3 27
NoneNone
PDSP KiDatabase 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 None
CHEMBL1256645 205211 3H-SCH23390 16 Human Binding pKi = 9.5 9.5 -3 27
NoneNone
PDSP KiDatabase 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 None
CHEMBL1814790 205211 3H-SCH23390 16 Human Binding pKi = 9.5 9.5 -3 27
NoneNone
PDSP KiDatabase 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 None
CHEMBL62 205211 3H-SCH23390 16 Human Binding pKi = 9.5 9.5 -3 27
NoneNone
PDSP KiDatabase 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 None
1243 3618 3H-SCH23390 30 Human Binding pKi = 9.4 9.4 -2 15
NoneNone
PDSP KiDatabase 331 1 1 2 3.8 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O None
944 3618 3H-SCH23390 30 Human Binding pKi = 9.4 9.4 -2 15
NoneNone
PDSP KiDatabase 331 1 1 2 3.8 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O None
CHEMBL324017 3618 3H-SCH23390 30 Human Binding pKi = 9.4 9.4 -2 15
NoneNone
PDSP KiDatabase 331 1 1 2 3.8 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O None
3036864 205211 3H-SCH23390 16 Rat Binding pKi = 9.3 9.3 -2 27
NoneNone
PDSP KiDatabase 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 None
CHEMBL1256645 205211 3H-SCH23390 16 Rat Binding pKi = 9.3 9.3 -2 27
NoneNone
PDSP KiDatabase 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 None
CHEMBL1814790 205211 3H-SCH23390 16 Rat Binding pKi = 9.3 9.3 -2 27
NoneNone
PDSP KiDatabase 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 None
CHEMBL62 205211 3H-SCH23390 16 Rat Binding pKi = 9.3 9.3 -2 27
NoneNone
PDSP KiDatabase 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 None
3036864 205211 3H-SCH23390 16 Rat Binding pKi = 9 9.0 -2 27
NoneNone
PDSP KiDatabase 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 None
CHEMBL1256645 205211 3H-SCH23390 16 Rat Binding pKi = 9 9.0 -2 27
NoneNone
PDSP KiDatabase 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 None
CHEMBL1814790 205211 3H-SCH23390 16 Rat Binding pKi = 9 9.0 -2 27
NoneNone
PDSP KiDatabase 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 None
CHEMBL62 205211 3H-SCH23390 16 Rat Binding pKi = 9 9.0 -2 27
NoneNone
PDSP KiDatabase 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 None
1242 3613 3H-SCH23390 17 Human Binding pKi = 7 7.0 -6 17
NoneNone
PDSP KiDatabase 255 1 3 3 2.4 Oc1cc2CCNCC(c2cc1O)c1ccccc1 None
935 3613 3H-SCH23390 17 Human Binding pKi = 7 7.0 -6 17
NoneNone
PDSP KiDatabase 255 1 3 3 2.4 Oc1cc2CCNCC(c2cc1O)c1ccccc1 None
CHEMBL286080 3613 3H-SCH23390 17 Human Binding pKi = 7 7.0 -6 17
NoneNone
PDSP KiDatabase 255 1 3 3 2.4 Oc1cc2CCNCC(c2cc1O)c1ccccc1 None
24840389 115277 3H-SCH23390 5 Human Binding pKi = 6 6.0 -741 15
NoneNone
PDSP KiDatabase 415 9 0 4 4.6 CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1 None
CHEMBL334529 115277 3H-SCH23390 5 Human Binding pKi = 6 6.0 -741 15
NoneNone
PDSP KiDatabase 415 9 0 4 4.6 CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1 None
44591012 175684 UNDEFINED 0 Human Binding pKi = 6 6.0 -204 6
NoneNone
PDSP KiDatabase 522 10 0 3 6.6 CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)Cc1ccc(OCCCN2CCCCC2)cc1 None
CHEMBL457957 175684 UNDEFINED 0 Human Binding pKi = 6 6.0 -204 6
NoneNone
PDSP KiDatabase 522 10 0 3 6.6 CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)Cc1ccc(OCCCN2CCCCC2)cc1 None
44591098 176867 UNDEFINED 0 Human Binding pKi = 6 6.0 -288 6
NoneNone
PDSP KiDatabase 508 9 0 3 6.6 CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)c1ccc(OCCCN2CCCCC2)cc1 None
CHEMBL460402 176867 UNDEFINED 0 Human Binding pKi = 6 6.0 -288 6
NoneNone
PDSP KiDatabase 508 9 0 3 6.6 CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)c1ccc(OCCCN2CCCCC2)cc1 None
3075702 219818 3H-SCH23390 0 Human Binding pKi = 6 6.0 -2 37
NoneNone
PDSP KiDatabase 198 3 1 3 1.5 C1CNC1COC2=CN=C(C=C2)Cl None
179 400 3H-SCH23390 72 Human Binding pKi = 5 5.0 -4365 50
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
2159 400 3H-SCH23390 72 Human Binding pKi = 5 5.0 -4365 50
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
2159.0 400 3H-SCH23390 72 Human Binding pKi = 5 5.0 -4365 50
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
963 400 3H-SCH23390 72 Human Binding pKi = 5 5.0 -4365 50
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
CHEMBL243712 400 3H-SCH23390 72 Human Binding pKi = 5 5.0 -4365 50
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
DB06288 400 3H-SCH23390 72 Human Binding pKi = 5 5.0 -4365 50
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
119192 2481 3H-SCH23390 38 Human Binding pKi = 5 5.0 -2818 9
NoneNone
PDSP KiDatabase 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC None
1582 2481 3H-SCH23390 38 Human Binding pKi = 5 5.0 -2818 9
NoneNone
PDSP KiDatabase 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC None
CHEMBL506981 2481 3H-SCH23390 38 Human Binding pKi = 5 5.0 -2818 9
NoneNone
PDSP KiDatabase 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC None
DB06455 2481 3H-SCH23390 38 Human Binding pKi = 5 5.0 -2818 9
NoneNone
PDSP KiDatabase 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC None
134 2514 3H-SCH23390 19 Human Binding pKi = 5 5.0 -8511 67
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 2514 3H-SCH23390 19 Human Binding pKi = 5 5.0 -8511 67
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 2514 3H-SCH23390 19 Human Binding pKi = 5 5.0 -8511 67
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681.0 2514 3H-SCH23390 19 Human Binding pKi = 5 5.0 -8511 67
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 2514 3H-SCH23390 19 Human Binding pKi = 5 5.0 -8511 67
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 2514 3H-SCH23390 19 Human Binding pKi = 5 5.0 -8511 67
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
484 2858 3H-SCH23390 34 Human Binding pKi = 5 5.0 -112 35
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
951 2858 3H-SCH23390 34 Human Binding pKi = 5 5.0 -112 35
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
CHEMBL432 2858 3H-SCH23390 34 Human Binding pKi = 5 5.0 -112 35
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
15897 2862 3H-SCH23390 0 Human Binding pKi = 5 5.0 -354 36
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
215 2862 3H-SCH23390 0 Human Binding pKi = 5 5.0 -354 36
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
CHEMBL1979333 2862 3H-SCH23390 0 Human Binding pKi = 5 5.0 -354 36
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
163839 2955 3H-SCH23390 0 Rat Binding pKi = 5 5.0 -562 7
NoneNone
PDSP KiDatabase 391 6 1 4 3.7 Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2 None
268 2955 3H-SCH23390 0 Rat Binding pKi = 5 5.0 -562 7
NoneNone
PDSP KiDatabase 391 6 1 4 3.7 Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2 None
CHEMBL55171 2955 3H-SCH23390 0 Rat Binding pKi = 5 5.0 -562 7
NoneNone
PDSP KiDatabase 391 6 1 4 3.7 Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2 None
2202 3132 3H-SCH23390 63 Human Binding pKi = 5 5.0 -316 21
NoneNone
PDSP KiDatabase 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
4850 3132 3H-SCH23390 63 Human Binding pKi = 5 5.0 -316 21
NoneNone
PDSP KiDatabase 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
4850.0 3132 3H-SCH23390 63 Human Binding pKi = 5 5.0 -316 21
NoneNone
PDSP KiDatabase 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
49 3132 3H-SCH23390 63 Human Binding pKi = 5 5.0 -316 21
NoneNone
PDSP KiDatabase 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
CHEMBL1371770 3132 3H-SCH23390 63 Human Binding pKi = 5 5.0 -316 21
NoneNone
PDSP KiDatabase 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
DB12478 3132 3H-SCH23390 63 Human Binding pKi = 5 5.0 -316 21
NoneNone
PDSP KiDatabase 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
119570 3159 3H-SCH23390 58 Human Binding pKi = 5 5.0 -7585 40
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
119570.0 3159 3H-SCH23390 58 Human Binding pKi = 5 5.0 -7585 40
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
2233 3159 3H-SCH23390 58 Human Binding pKi = 5 5.0 -7585 40
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
953 3159 3H-SCH23390 58 Human Binding pKi = 5 5.0 -7585 40
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
CHEMBL301265 3159 3H-SCH23390 58 Human Binding pKi = 5 5.0 -7585 40
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
DB00413 3159 3H-SCH23390 58 Human Binding pKi = 5 5.0 -7585 40
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
2 3261 3H-SCH23390 19 Human Binding pKi = 5 5.0 -2089 28
NoneNone
PDSP KiDatabase 219 2 1 2 2.0 CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 None
54562 3261 3H-SCH23390 19 Human Binding pKi = 5 5.0 -2089 28
NoneNone
PDSP KiDatabase 219 2 1 2 2.0 CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 None
CHEMBL240773 3261 3H-SCH23390 19 Human Binding pKi = 5 5.0 -2089 28
NoneNone
PDSP KiDatabase 219 2 1 2 2.0 CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 None
2402 3370 3H-SCH23390 38 Human Binding pKi = 5 5.0 -81 25
NoneNone
PDSP KiDatabase 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
5095 3370 3H-SCH23390 38 Human Binding pKi = 5 5.0 -81 25
NoneNone
PDSP KiDatabase 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
5095.0 3370 3H-SCH23390 38 Human Binding pKi = 5 5.0 -81 25
NoneNone
PDSP KiDatabase 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
7295 3370 3H-SCH23390 38 Human Binding pKi = 5 5.0 -81 25
NoneNone
PDSP KiDatabase 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
CHEMBL589 3370 3H-SCH23390 38 Human Binding pKi = 5 5.0 -81 25
NoneNone
PDSP KiDatabase 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
DB00268 3370 3H-SCH23390 38 Human Binding pKi = 5 5.0 -81 25
NoneNone
PDSP KiDatabase 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
128563 3464 3H-SCH23390 24 Human Binding pKi = 5 5.0 -2344 41
NoneNone
PDSP KiDatabase 432 3 0 8 3.0 COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 None
1666 3464 3H-SCH23390 24 Human Binding pKi = 5 5.0 -2344 41
NoneNone
PDSP KiDatabase 432 3 0 8 3.0 COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 None
CHEMBL445332 3464 3H-SCH23390 24 Human Binding pKi = 5 5.0 -2344 41
NoneNone
PDSP KiDatabase 432 3 0 8 3.0 COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 None
DB12327 3464 3H-SCH23390 24 Human Binding pKi = 5 5.0 -2344 41
NoneNone
PDSP KiDatabase 432 3 0 8 3.0 COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 None
213 3853 3H-SCH23390 34 Human Binding pKi = 5 5.0 -549 43
NoneNone
PDSP KiDatabase 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
2717 3853 3H-SCH23390 34 Human Binding pKi = 5 5.0 -549 43
NoneNone
PDSP KiDatabase 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
5533 3853 3H-SCH23390 34 Human Binding pKi = 5 5.0 -549 43
NoneNone
PDSP KiDatabase 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
5533.0 3853 3H-SCH23390 34 Human Binding pKi = 5 5.0 -549 43
NoneNone
PDSP KiDatabase 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
CHEMBL621 3853 3H-SCH23390 34 Human Binding pKi = 5 5.0 -549 43
NoneNone
PDSP KiDatabase 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
DB00656 3853 3H-SCH23390 34 Human Binding pKi = 5 5.0 -549 43
NoneNone
PDSP KiDatabase 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
185 4006 3H-SCH23390 43 Human Binding pKi = 5 5.0 -29512 37
NoneNone
PDSP KiDatabase 373 7 1 4 3.8 COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O None
5311271 4006 3H-SCH23390 43 Human Binding pKi = 5 5.0 -29512 37
NoneNone
PDSP KiDatabase 373 7 1 4 3.8 COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O None
CHEMBL74355 4006 3H-SCH23390 43 Human Binding pKi = 5 5.0 -29512 37
NoneNone
PDSP KiDatabase 373 7 1 4 3.8 COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O None
DB16351 4006 3H-SCH23390 43 Human Binding pKi = 5 5.0 -29512 37
NoneNone
PDSP KiDatabase 373 7 1 4 3.8 COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O None
2662 11388 3H-SCH23390 77 Human Binding pKi = 5 5.0 -41 31
NoneNone
PDSP KiDatabase 381 3 1 4 3.5 Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 None
CHEMBL118 11388 3H-SCH23390 77 Human Binding pKi = 5 5.0 -41 31
NoneNone
PDSP KiDatabase 381 3 1 4 3.5 Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 None
5090 15568 3H-SCH23390 65 Human Binding pKi = 5 5.0 -1348 31
NoneNone
PDSP KiDatabase 314 3 0 4 2.6 CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1 None
CHEMBL122 15568 3H-SCH23390 65 Human Binding pKi = 5 5.0 -1348 31
NoneNone
PDSP KiDatabase 314 3 0 4 2.6 CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1 None
10297 27120 3H-SCH23390 13 Human Binding pKi = 5 5.0 -38 42
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 C[C@H](N)[C@H](O)c1ccccc1 None
CHEMBL136560 27120 3H-SCH23390 13 Human Binding pKi = 5 5.0 -38 42
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 C[C@H](N)[C@H](O)c1ccccc1 None
156391 46814 3H-SCH23390 58 Human Binding pKi = 5 5.0 -1 30
NoneNone
PDSP KiDatabase 230 3 1 2 3.0 COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 None
CHEMBL1200806 46814 3H-SCH23390 58 Human Binding pKi = 5 5.0 -1 30
NoneNone
PDSP KiDatabase 230 3 1 2 3.0 COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 None
CHEMBL154 46814 3H-SCH23390 58 Human Binding pKi = 5 5.0 -1 30
NoneNone
PDSP KiDatabase 230 3 1 2 3.0 COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 None
10624 70324 3H-SCH23390 12 Human Binding pKi = 5 5.0 -102 32
NoneNone
PDSP KiDatabase 284 5 3 3 1.7 CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 None
10624.0 70324 3H-SCH23390 12 Human Binding pKi = 5 5.0 -102 32
NoneNone
PDSP KiDatabase 284 5 3 3 1.7 CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 None
138543650 70324 3H-SCH23390 12 Human Binding pKi = 5 5.0 -102 32
NoneNone
PDSP KiDatabase 284 5 3 3 1.7 CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 None
CHEMBL194378 70324 3H-SCH23390 12 Human Binding pKi = 5 5.0 -102 32
NoneNone
PDSP KiDatabase 284 5 3 3 1.7 CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 None
DB11664 70324 3H-SCH23390 12 Human Binding pKi = 5 5.0 -102 32
NoneNone
PDSP KiDatabase 284 5 3 3 1.7 CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 None
2244 94286 3H-SCH23390 63 Human Binding pKi = 5 5.0 -1 28
NoneNone
PDSP KiDatabase 180 2 1 3 1.3 CC(=O)Oc1ccccc1C(=O)O None
CHEMBL25 94286 3H-SCH23390 63 Human Binding pKi = 5 5.0 -1 28
NoneNone
PDSP KiDatabase 180 2 1 3 1.3 CC(=O)Oc1ccccc1C(=O)O None
7153 98073 3H-SCH23390 55 Human Binding pKi = 5 5.0 -524 33
NoneNone
PDSP KiDatabase 214 3 1 2 2.5 Cc1cc(Cl)ccc1OC(C)C(=O)O None
CHEMBL272942 98073 3H-SCH23390 55 Human Binding pKi = 5 5.0 -524 33
NoneNone
PDSP KiDatabase 214 3 1 2 2.5 Cc1cc(Cl)ccc1OC(C)C(=O)O None
3663 100021 3H-SCH23390 53 Human Binding pKi = 5 5.0 -288 29
NoneNone
PDSP KiDatabase 504 0 6 8 5.1 Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65 None
CHEMBL286494 100021 3H-SCH23390 53 Human Binding pKi = 5 5.0 -288 29
NoneNone
PDSP KiDatabase 504 0 6 8 5.1 Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65 None
446220 133590 3H-SCH23390 7 Human Binding pKi = 5 5.0 -1778 45
NoneNone
PDSP KiDatabase 303 3 0 5 1.9 COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C None
CHEMBL370805 133590 3H-SCH23390 7 Human Binding pKi = 5 5.0 -1778 45
NoneNone
PDSP KiDatabase 303 3 0 5 1.9 COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C None
1615 167894 3H-SCH23390 12 Human Binding pKi = 5 5.0 -26 44
NoneNone
PDSP KiDatabase 193 3 1 3 1.6 CNC(C)Cc1ccc2c(c1)OCO2 None
CHEMBL43048 167894 3H-SCH23390 12 Human Binding pKi = 5 5.0 -26 44
NoneNone
PDSP KiDatabase 193 3 1 3 1.6 CNC(C)Cc1ccc2c(c1)OCO2 None
5280343 188382 3H-SCH23390 69 Human Binding pKi = 5 5.0 -147 32
NoneNone
PDSP KiDatabase 302 1 5 7 2.0 O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 None
CHEMBL1520590 188382 3H-SCH23390 69 Human Binding pKi = 5 5.0 -147 32
NoneNone
PDSP KiDatabase 302 1 5 7 2.0 O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 None
CHEMBL50 188382 3H-SCH23390 69 Human Binding pKi = 5 5.0 -147 32
NoneNone
PDSP KiDatabase 302 1 5 7 2.0 O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 None
3672 192642 3H-SCH23390 78 Human Binding pKi = 5 5.0 -1 28
NoneNone
PDSP KiDatabase 206 4 1 1 3.1 CC(C)Cc1ccc(C(C)C(=O)O)cc1 None
CHEMBL521 192642 3H-SCH23390 78 Human Binding pKi = 5 5.0 -1 28
NoneNone
PDSP KiDatabase 206 4 1 1 3.1 CC(C)Cc1ccc(C(C)C(=O)O)cc1 None
54676228 193723 3H-SCH23390 67 Human Binding pKi = 5 5.0 -1 28
NoneNone
PDSP KiDatabase 331 2 2 5 1.6 CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O None
CHEMBL527 193723 3H-SCH23390 67 Human Binding pKi = 5 5.0 -1 28
NoneNone
PDSP KiDatabase 331 2 2 5 1.6 CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O None
4495 198991 3H-SCH23390 63 Human Binding pKi = 5 5.0 -1 30
NoneNone
PDSP KiDatabase 308 5 1 5 2.8 CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 None
CHEMBL56367 198991 3H-SCH23390 63 Human Binding pKi = 5 5.0 -1 30
NoneNone
PDSP KiDatabase 308 5 1 5 2.8 CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 None
54677470 203007 3H-SCH23390 67 Human Binding pKi = 5 5.0 -1 30
NoneNone
PDSP KiDatabase 351 2 2 6 2.0 Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 None
CHEMBL1256873 203007 3H-SCH23390 67 Human Binding pKi = 5 5.0 -1 30
NoneNone
PDSP KiDatabase 351 2 2 6 2.0 Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 None
CHEMBL599 203007 3H-SCH23390 67 Human Binding pKi = 5 5.0 -1 30
NoneNone
PDSP KiDatabase 351 2 2 6 2.0 Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 None
162265 204731 3H-SCH23390 11 Human Binding pKi = 5 5.0 -1949 44
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
4786 204731 3H-SCH23390 11 Human Binding pKi = 5 5.0 -1949 44
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
CHEMBL61006 204731 3H-SCH23390 11 Human Binding pKi = 5 5.0 -1949 44
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
5281600 205483 3H-SCH23390 63 Human Binding pKi = 5 5.0 -275 33
NoneNone
PDSP KiDatabase 538 3 6 10 5.1 O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12 None
CHEMBL63354 205483 3H-SCH23390 63 Human Binding pKi = 5 5.0 -275 33
NoneNone
PDSP KiDatabase 538 3 6 10 5.1 O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12 None
1973 205941 3H-SCH23390 12 Rat Binding pKi = 5 5.0 -3 36
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL1394464 205941 3H-SCH23390 12 Rat Binding pKi = 5 5.0 -3 36
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL66089 205941 3H-SCH23390 12 Rat Binding pKi = 5 5.0 -3 36
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
202478 207145 3H-SCH23390 19 Human Binding pKi = 5 5.0 -97 25
NoneNone
PDSP KiDatabase 219 3 1 2 3.0 CCCN1CCC[C@H](c2cccc(O)c2)C1 None
CHEMBL7393 207145 3H-SCH23390 19 Human Binding pKi = 5 5.0 -97 25
NoneNone
PDSP KiDatabase 219 3 1 2 3.0 CCCN1CCC[C@H](c2cccc(O)c2)C1 None
3821 207176 3H-SCH23390 11 Human Binding pKi = 5 5.0 -1 18
NoneNone
PDSP KiDatabase 237 2 1 2 2.9 CNC1(c2ccccc2Cl)CCCCC1=O None
CHEMBL742 207176 3H-SCH23390 11 Human Binding pKi = 5 5.0 -1 18
NoneNone
PDSP KiDatabase 237 2 1 2 2.9 CNC1(c2ccccc2Cl)CCCCC1=O None
4054 207959 3H-SCH23390 46 Human Binding pKi = 5 5.0 -1 37
NoneNone
PDSP KiDatabase 179 0 1 1 2.7 CC12CC3CC(C)(C1)CC(N)(C3)C2 None
CHEMBL1699 207959 3H-SCH23390 46 Human Binding pKi = 5 5.0 -1 37
NoneNone
PDSP KiDatabase 179 0 1 1 2.7 CC12CC3CC(C)(C1)CC(N)(C3)C2 None
CHEMBL807 207959 3H-SCH23390 46 Human Binding pKi = 5 5.0 -1 37
NoneNone
PDSP KiDatabase 179 0 1 1 2.7 CC12CC3CC(C)(C1)CC(N)(C3)C2 None
119607 208661 3H-SCH23390 64 Human Binding pKi = 5 5.0 -97 28
NoneNone
PDSP KiDatabase 314 3 1 4 3.0 Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 None
CHEMBL865 208661 3H-SCH23390 64 Human Binding pKi = 5 5.0 -97 28
NoneNone
PDSP KiDatabase 314 3 1 4 3.0 Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 None
3337 208825 3H-SCH23390 14 Human Binding pKi = 5 5.0 -1513 40
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
3337.0 208825 3H-SCH23390 14 Human Binding pKi = 5 5.0 -1513 40
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
65801 208825 3H-SCH23390 14 Human Binding pKi = 5 5.0 -1513 40
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
66264 208825 3H-SCH23390 14 Human Binding pKi = 5 5.0 -1513 40
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
91452 208825 3H-SCH23390 14 Human Binding pKi = 5 5.0 -1513 40
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
CHEMBL87493 208825 3H-SCH23390 14 Human Binding pKi = 5 5.0 -1513 40
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
DB00574 208825 3H-SCH23390 14 Human Binding pKi = 5 5.0 -1513 40
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
164512405 218439 3H-SCH23390 0 Human Binding pKi = 5 5.0 -457 12
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC None
5355 218439 3H-SCH23390 0 Human Binding pKi = 5 5.0 -457 12
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC None
5355.0 218439 3H-SCH23390 0 Human Binding pKi = 5 5.0 -457 12
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC None
CHEMBL26 218439 3H-SCH23390 0 Human Binding pKi = 5 5.0 -457 12
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC None
DB00391 218439 3H-SCH23390 0 Human Binding pKi = 5 5.0 -457 12
NoneNone
PDSP KiDatabase 341 6 2 5 0.6 CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC None
44134711 218481 3H-SCH23390 0 Human Binding pKi = 5 5.0 -112201 13
NoneNone
PDSP KiDatabase 340 6 2 4 2.8 CCC1=CC(=C(C(=C1O)C(=O)NCC2CCCN2CC)OC)Cl None
None 218483 3H-SCH23390 0 Human Binding pKi = 5 5.0 -1 27
NoneNone
PDSP KiDatabase 329 2 0 4 3.6 CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C.Cl None
104911 218509 3H-SCH23390 0 Human Binding pKi = 5 5.0 -41686 37
NoneNone
PDSP KiDatabase 530 7 0 5 5.1 COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl None
25137849 218667 3H-SCH23390 0 Human Binding pKi = 5 5.0 -4 40
NoneNone
PDSP KiDatabase 165 3 2 2 1.3 CC(C(C1=CC=CC=C1)O)NC None
71290 218667 3H-SCH23390 0 Human Binding pKi = 5 5.0 -4 40
NoneNone
PDSP KiDatabase 165 3 2 2 1.3 CC(C(C1=CC=CC=C1)O)NC None
None 218721 3H-SCH23390 0 Human Binding pKi = 5 5.0 -13 6
NoneNone
PDSP KiDatabase 255 2 1 2 2.4 CCCN1CCCC2C1CC3=C(C2)NN=C3.Cl None
None 218726 3H-SCH23390 0 Human Binding pKi = 5 5.0 -95499 29
NoneNone
PDSP KiDatabase 316 7 3 3 3.0 CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O None
None 218798 3H-SCH23390 0 Human Binding pKi = 5 5.0 -1 33
NoneNone
PDSP KiDatabase 240 7 4 6 -0.8 C(C(C(=O)O)N)SSCC(C(=O)O)N None
None 218799 3H-SCH23390 0 Human Binding pKi = 5 5.0 -1 33
NoneNone
PDSP KiDatabase 149 4 2 3 0.2 CSCCC(C(=O)O)N None
None 218800 3H-SCH23390 0 Human Binding pKi = 5 5.0 -1 33
NoneNone
PDSP KiDatabase 135 3 3 3 -0.3 C(CS)C(C(=O)O)N None
None 218801 3H-SCH23390 0 Human Binding pKi = 5 5.0 -1 33
NoneNone
PDSP KiDatabase 121 2 3 3 -0.7 C(C(C(=O)O)N)S None
None 218802 3H-SCH23390 0 Human Binding pKi = 5 5.0 -1 28
NoneNone
PDSP KiDatabase 117 0 1 3 -0.0 C1CSC(=O)C1N None
None 218803 3H-SCH23390 0 Human Binding pKi = 5 5.0 -1 39
NoneNone
PDSP KiDatabase 153 3 3 3 -1.4 C(C(C(=O)O)N)S(=O)O None
None 218804 3H-SCH23390 0 Human Binding pKi = 5 5.0 -1 38
NoneNone
PDSP KiDatabase 169 3 3 4 -1.7 C(C(C(=O)O)N)S(=O)(=O)O None
None 218805 3H-SCH23390 0 Human Binding pKi = 5 5.0 -1 29
NoneNone
PDSP KiDatabase 183 4 3 4 -1.3 C(CS(=O)(=O)O)C(C(=O)O)N None
None 218812 3H-SCH23390 0 Human Binding pKi = 5 5.0 -13 40
NoneNone
PDSP KiDatabase 149 2 1 2 1.2 CC(C(=O)C1=CC=CC=C1)N None
1576 218813 3H-SCH23390 0 Human Binding pKi = 5 5.0 -16 40
NoneNone
PDSP KiDatabase 163 3 1 2 1.5 CC(C(=O)C1=CC=CC=C1)NC None
None 218814 3H-SCH23390 0 Human Binding pKi = 5 5.0 -16 28
NoneNone
PDSP KiDatabase 536 11 1 4 9.0 CC(C)C(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C None
4978 218815 3H-SCH23390 0 Human Binding pKi = 5 5.0 -16 28
NoneNone
PDSP KiDatabase 520 1 7 9 4.3 CC1=CC(=C2C3=C1C4=C5C(=C(C=C4CO)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O None
None 218816 3H-SCH23390 0 Human Binding pKi = 5 5.0 -3 28
NoneNone
PDSP KiDatabase 464 4 8 12 -0.6 C1=CC(=C(C=C1C2=C(C(=C3C(=CC(=O)C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O None
None 218817 3H-SCH23390 0 Human Binding pKi = 5 5.0 -281 28
NoneNone
PDSP KiDatabase 610 6 10 16 -1.7 CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O None
None 218818 3H-SCH23390 0 Human Binding pKi = 5 5.0 -1 28
NoneNone
PDSP KiDatabase 448 3 7 11 0.4 CC1C(C(C(C(O1)OC2=C(OC3=CC(=O)C=C(C3=C2O)O)C4=CC(=C(C=C4)O)O)O)O)O None
None 218829 3H-SCH23390 0 Human Binding pKi = 5 5.0 -1862 19
NoneNone
PDSP KiDatabase 246 2 1 4 1.6 CCCN1CCCC2C1CC3=CN=C(N=C3C2)N None
135269 218876 3H-SCH23390 0 Human Binding pKi = 5 5.0 -1 30
NoneNone
PDSP KiDatabase 222 5 1 3 2.5 CCCCC(=O)OC1=CC=CC=C1C(=O)O None
23681059 218877 3H-SCH23390 0 Human Binding pKi = 5 5.0 -1 29
NoneNone
PDSP KiDatabase 230 3 1 2 3.0 CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O None
5018304 218878 3H-SCH23390 0 Human Binding pKi = 5 5.0 -1 29
NoneNone
PDSP KiDatabase 317 4 1 3 0.0 C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+] None
84003 218879 3H-SCH23390 0 Human Binding pKi = 5 5.0 -1 28
NoneNone
PDSP KiDatabase 376 6 5 7 -0.0 C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O None
123619 218880 3H-SCH23390 0 Human Binding pKi = 5 5.0 -1412 27
NoneNone
PDSP KiDatabase 358 3 0 4 4.2 CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl None
119828 218881 3H-SCH23390 0 Human Binding pKi = 5 5.0 -1 30
NoneNone
PDSP KiDatabase 370 5 1 5 3.5 CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C None
None 218882 3H-SCH23390 0 Human Binding pKi = 5 5.0 -7 29
NoneNone
PDSP KiDatabase 517 8 2 5 5.2 CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C None
None 218718 3H-SCH23390 0 Human Binding pKi = 7.0 7.0 -281 2
NoneNone
PDSP KiDatabase 575 5 3 6 2.4 CCC(C)C1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=CNC7=CC=CC(=C67)C5=C4)C)O None
30137 2877 3H-SCH23390 0 Human Binding pKi = 5.9 5.9 -3019 10
NoneNone
PDSP KiDatabase 295 2 2 3 3.6 CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O None
8594 2877 3H-SCH23390 0 Human Binding pKi = 5.9 5.9 -3019 10
NoneNone
PDSP KiDatabase 295 2 2 3 3.6 CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O None
934 2877 3H-SCH23390 0 Human Binding pKi = 5.9 5.9 -3019 10
NoneNone
PDSP KiDatabase 295 2 2 3 3.6 CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O None
1212 1662 3H-SCH23390 37 Human Binding pKi = 7.9 7.9 -28 65
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
204 1662 3H-SCH23390 37 Human Binding pKi = 7.9 7.9 -28 65
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
3372 1662 3H-SCH23390 37 Human Binding pKi = 7.9 7.9 -28 65
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
3372.0 1662 3H-SCH23390 37 Human Binding pKi = 7.9 7.9 -28 65
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL726 1662 3H-SCH23390 37 Human Binding pKi = 7.9 7.9 -28 65
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00623 1662 3H-SCH23390 37 Human Binding pKi = 7.9 7.9 -28 65
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
242 470 3H-SCH23390 70 Rat Binding pKi = 5.9 5.9 -870 51
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
34 470 3H-SCH23390 70 Rat Binding pKi = 5.9 5.9 -870 51
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
60795 470 3H-SCH23390 70 Rat Binding pKi = 5.9 5.9 -870 51
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
60795.0 470 3H-SCH23390 70 Rat Binding pKi = 5.9 5.9 -870 51
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL1112 470 3H-SCH23390 70 Rat Binding pKi = 5.9 5.9 -870 51
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
DB01238 470 3H-SCH23390 70 Rat Binding pKi = 5.9 5.9 -870 51
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
124936 220178 3H-SCH23390 0 Human Binding pKi = 7.9 7.9 -6 7
NoneNone
PDSP KiDatabase 268 3 1 5 4.8 CNC1=CC=C(C=C1)N=NC2=CC3=C(C=C2)N=CS3 None
2726 919 3H-SCH23390 48 Human Binding pKi = 6.9 6.9 -47 72
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
2726.0 919 3H-SCH23390 48 Human Binding pKi = 6.9 6.9 -47 72
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 919 3H-SCH23390 48 Human Binding pKi = 6.9 6.9 -47 72
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 919 3H-SCH23390 48 Human Binding pKi = 6.9 6.9 -47 72
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 919 3H-SCH23390 48 Human Binding pKi = 6.9 6.9 -47 72
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 919 3H-SCH23390 48 Human Binding pKi = 6.9 6.9 -47 72
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
1212 1662 3H-SCH23390 37 Human Binding pKi = 7.9 7.9 -28 65
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
204 1662 3H-SCH23390 37 Human Binding pKi = 7.9 7.9 -28 65
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
3372 1662 3H-SCH23390 37 Human Binding pKi = 7.9 7.9 -28 65
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
3372.0 1662 3H-SCH23390 37 Human Binding pKi = 7.9 7.9 -28 65
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL726 1662 3H-SCH23390 37 Human Binding pKi = 7.9 7.9 -28 65
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00623 1662 3H-SCH23390 37 Human Binding pKi = 7.9 7.9 -28 65
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
25058166 218450 3H-SCH23390 0 Human Binding pKi = 7.8 7.8 -37 26
NoneNone
PDSP KiDatabase 267 0 2 3 2.9 CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O None
6852389 218450 3H-SCH23390 0 Human Binding pKi = 7.8 7.8 -37 26
NoneNone
PDSP KiDatabase 267 0 2 3 2.9 CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O None
1353 1911 3H-SCH23390 63 Human Binding pKi = 6.8 6.8 -54 85
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 1911 3H-SCH23390 63 Human Binding pKi = 6.8 6.8 -54 85
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559.0 1911 3H-SCH23390 63 Human Binding pKi = 6.8 6.8 -54 85
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 1911 3H-SCH23390 63 Human Binding pKi = 6.8 6.8 -54 85
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 1911 3H-SCH23390 63 Human Binding pKi = 6.8 6.8 -54 85
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 1911 3H-SCH23390 63 Human Binding pKi = 6.8 6.8 -54 85
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
1153 1628 3H-SCH23390 36 Human Binding pKi = 7.8 7.8 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
12668023 1628 3H-SCH23390 36 Human Binding pKi = 7.8 7.8 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
30026874 1628 3H-SCH23390 36 Human Binding pKi = 7.8 7.8 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
30026875 1628 3H-SCH23390 36 Human Binding pKi = 7.8 7.8 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
3341 1628 3H-SCH23390 36 Human Binding pKi = 7.8 7.8 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
3341.0 1628 3H-SCH23390 36 Human Binding pKi = 7.8 7.8 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
6603851 1628 3H-SCH23390 36 Human Binding pKi = 7.8 7.8 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
933 1628 3H-SCH23390 36 Human Binding pKi = 7.8 7.8 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
939 1628 3H-SCH23390 36 Human Binding pKi = 7.8 7.8 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
985 1628 3H-SCH23390 36 Human Binding pKi = 7.8 7.8 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
CHEMBL1160786 1628 3H-SCH23390 36 Human Binding pKi = 7.8 7.8 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
CHEMBL1161520 1628 3H-SCH23390 36 Human Binding pKi = 7.8 7.8 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
CHEMBL588 1628 3H-SCH23390 36 Human Binding pKi = 7.8 7.8 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
DB00800 1628 3H-SCH23390 36 Human Binding pKi = 7.8 7.8 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
2337 3256 3H-SCH23390 51 Human Binding pKi = 5.8 5.8 -27 62
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 3256 3H-SCH23390 51 Human Binding pKi = 5.8 5.8 -27 62
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 3256 3H-SCH23390 51 Human Binding pKi = 5.8 5.8 -27 62
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002.0 3256 3H-SCH23390 51 Human Binding pKi = 5.8 5.8 -27 62
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 3256 3H-SCH23390 51 Human Binding pKi = 5.8 5.8 -27 62
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 3256 3H-SCH23390 51 Human Binding pKi = 5.8 5.8 -27 62
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
2865 4143 3H-SCH23390 47 Human Binding pKi = 6.8 6.8 -64 53
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
59 4143 3H-SCH23390 47 Human Binding pKi = 6.8 6.8 -64 53
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
60854 4143 3H-SCH23390 47 Human Binding pKi = 6.8 6.8 -64 53
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
60854.0 4143 3H-SCH23390 47 Human Binding pKi = 6.8 6.8 -64 53
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
CHEMBL708 4143 3H-SCH23390 47 Human Binding pKi = 6.8 6.8 -64 53
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
DB00246 4143 3H-SCH23390 47 Human Binding pKi = 6.8 6.8 -64 53
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
44591134 176304 UNDEFINED 0 Human Binding pKi = 6.8 6.8 -125 6
NoneNone
PDSP KiDatabase 535 11 0 5 7.7 CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1 None
CHEMBL459373 176304 UNDEFINED 0 Human Binding pKi = 6.8 6.8 -125 6
NoneNone
PDSP KiDatabase 535 11 0 5 7.7 CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1 None
2389 3331 3H-SCH23390 72 Human Binding pKi = 7.8 7.8 -234 67
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 3331 3H-SCH23390 72 Human Binding pKi = 7.8 7.8 -234 67
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073.0 3331 3H-SCH23390 72 Human Binding pKi = 7.8 7.8 -234 67
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 3331 3H-SCH23390 72 Human Binding pKi = 7.8 7.8 -234 67
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 3331 3H-SCH23390 72 Human Binding pKi = 7.8 7.8 -234 67
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 3331 3H-SCH23390 72 Human Binding pKi = 7.8 7.8 -234 67
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
6603820 95827 3H-SCH23390 16 Rat Binding pKi = 7.8 7.8 -1 13
NoneNone
PDSP KiDatabase 267 0 3 3 2.6 Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2 None
CHEMBL25856 95827 3H-SCH23390 16 Rat Binding pKi = 7.8 7.8 -1 13
NoneNone
PDSP KiDatabase 267 0 3 3 2.6 Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2 None
242 470 3H-SCH23390 70 Human Binding pKi = 5.8 5.8 -380 51
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
34 470 3H-SCH23390 70 Human Binding pKi = 5.8 5.8 -380 51
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
60795 470 3H-SCH23390 70 Human Binding pKi = 5.8 5.8 -380 51
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
60795.0 470 3H-SCH23390 70 Human Binding pKi = 5.8 5.8 -380 51
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL1112 470 3H-SCH23390 70 Human Binding pKi = 5.8 5.8 -380 51
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
DB01238 470 3H-SCH23390 70 Human Binding pKi = 5.8 5.8 -380 51
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
180 401 UNDEFINED 38 Human Binding pKi = 6.8 6.8 -112 39
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
200 401 UNDEFINED 38 Human Binding pKi = 6.8 6.8 -112 39
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
2160 401 UNDEFINED 38 Human Binding pKi = 6.8 6.8 -112 39
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
2160.0 401 UNDEFINED 38 Human Binding pKi = 6.8 6.8 -112 39
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
CHEMBL629 401 UNDEFINED 38 Human Binding pKi = 6.8 6.8 -112 39
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
DB00321 401 UNDEFINED 38 Human Binding pKi = 6.8 6.8 -112 39
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
11954224 218443 3H-SCH23390 0 Human Binding pKi = 6.8 6.8 -478 59
NoneNone
PDSP KiDatabase 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
3251 218443 3H-SCH23390 0 Human Binding pKi = 6.8 6.8 -478 59
NoneNone
PDSP KiDatabase 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
3251.0 218443 3H-SCH23390 0 Human Binding pKi = 6.8 6.8 -478 59
NoneNone
PDSP KiDatabase 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
CHEMBL1982133 218443 3H-SCH23390 0 Human Binding pKi = 6.8 6.8 -478 59
NoneNone
PDSP KiDatabase 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
DB00696 218443 3H-SCH23390 0 Human Binding pKi = 6.8 6.8 -478 59
NoneNone
PDSP KiDatabase 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
2726 919 UNDEFINED 48 Human Binding pKi = 6.8 6.8 -47 72
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
2726.0 919 UNDEFINED 48 Human Binding pKi = 6.8 6.8 -47 72
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 919 UNDEFINED 48 Human Binding pKi = 6.8 6.8 -47 72
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 919 UNDEFINED 48 Human Binding pKi = 6.8 6.8 -47 72
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 919 UNDEFINED 48 Human Binding pKi = 6.8 6.8 -47 72
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 919 UNDEFINED 48 Human Binding pKi = 6.8 6.8 -47 72
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
2337 3256 3H-SCH23390 51 Human Binding pKi = 5.8 5.8 -27 62
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 3256 3H-SCH23390 51 Human Binding pKi = 5.8 5.8 -27 62
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 3256 3H-SCH23390 51 Human Binding pKi = 5.8 5.8 -27 62
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002.0 3256 3H-SCH23390 51 Human Binding pKi = 5.8 5.8 -27 62
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 3256 3H-SCH23390 51 Human Binding pKi = 5.8 5.8 -27 62
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 3256 3H-SCH23390 51 Human Binding pKi = 5.8 5.8 -27 62
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
1353 1911 3H-SCH23390 63 Human Binding pKi = 6.8 6.8 -54 85
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 1911 3H-SCH23390 63 Human Binding pKi = 6.8 6.8 -54 85
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559.0 1911 3H-SCH23390 63 Human Binding pKi = 6.8 6.8 -54 85
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 1911 3H-SCH23390 63 Human Binding pKi = 6.8 6.8 -54 85
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 1911 3H-SCH23390 63 Human Binding pKi = 6.8 6.8 -54 85
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 1911 3H-SCH23390 63 Human Binding pKi = 6.8 6.8 -54 85
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
219050 3373 3H-SCH23390 19 Human Binding pKi = 6.7 6.7 -1174 21
NoneNone
PDSP KiDatabase 346 6 2 2 5.0 Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 None
52 3373 3H-SCH23390 19 Human Binding pKi = 6.7 6.7 -1174 21
NoneNone
PDSP KiDatabase 346 6 2 2 5.0 Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 None
CHEMBL431367 3373 3H-SCH23390 19 Human Binding pKi = 6.7 6.7 -1174 21
NoneNone
PDSP KiDatabase 346 6 2 2 5.0 Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 None
135398737 958 UNDEFINED 57 Human Binding pKi = 6.7 6.7 -89 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
135398737.0 958 UNDEFINED 57 Human Binding pKi = 6.7 6.7 -89 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 958 UNDEFINED 57 Human Binding pKi = 6.7 6.7 -89 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 958 UNDEFINED 57 Human Binding pKi = 6.7 6.7 -89 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 958 UNDEFINED 57 Human Binding pKi = 6.7 6.7 -89 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 958 UNDEFINED 57 Human Binding pKi = 6.7 6.7 -89 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
1212 1662 UNDEFINED 37 Human Binding pKi = 7.7 7.7 -28 65
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
204 1662 UNDEFINED 37 Human Binding pKi = 7.7 7.7 -28 65
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
3372 1662 UNDEFINED 37 Human Binding pKi = 7.7 7.7 -28 65
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
3372.0 1662 UNDEFINED 37 Human Binding pKi = 7.7 7.7 -28 65
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL726 1662 UNDEFINED 37 Human Binding pKi = 7.7 7.7 -28 65
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00623 1662 UNDEFINED 37 Human Binding pKi = 7.7 7.7 -28 65
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
100 3805 3H-SCH23390 44 Human Binding pKi = 6.7 6.7 -85 55
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
2637 3805 3H-SCH23390 44 Human Binding pKi = 6.7 6.7 -85 55
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
5452 3805 3H-SCH23390 44 Human Binding pKi = 6.7 6.7 -85 55
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
CHEMBL479 3805 3H-SCH23390 44 Human Binding pKi = 6.7 6.7 -85 55
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
DB00679 3805 3H-SCH23390 44 Human Binding pKi = 6.7 6.7 -85 55
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
None 218828 3H-SCH23390 0 Human Binding pKi = 7.7 7.7 -29 19
NoneNone
PDSP KiDatabase 451 8 2 4 3.2 CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C None
3036780 107587 3H-SCH23390 16 Human Binding pKi = 7.6 7.6 -77 53
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
3036780.0 107587 3H-SCH23390 16 Human Binding pKi = 7.6 7.6 -77 53
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
46780481 107587 3H-SCH23390 16 Human Binding pKi = 7.6 7.6 -77 53
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
9903970 107587 3H-SCH23390 16 Human Binding pKi = 7.6 7.6 -77 53
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
9903970.0 107587 3H-SCH23390 16 Human Binding pKi = 7.6 7.6 -77 53
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL3187365 107587 3H-SCH23390 16 Human Binding pKi = 7.6 7.6 -77 53
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL3544974 107587 3H-SCH23390 16 Human Binding pKi = 7.6 7.6 -77 53
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL504548 107587 3H-SCH23390 16 Human Binding pKi = 7.6 7.6 -77 53
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
DB06216 107587 3H-SCH23390 16 Human Binding pKi = 7.6 7.6 -77 53
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
681 1465 3H-SCH23390 47 Human Binding pKi = 6.6 6.6 -67 38
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
681.0 1465 3H-SCH23390 47 Human Binding pKi = 6.6 6.6 -67 38
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
940 1465 3H-SCH23390 47 Human Binding pKi = 6.6 6.6 -67 38
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
947 1465 3H-SCH23390 47 Human Binding pKi = 6.6 6.6 -67 38
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
CHEMBL59 1465 3H-SCH23390 47 Human Binding pKi = 6.6 6.6 -67 38
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
DB00988 1465 3H-SCH23390 47 Human Binding pKi = 6.6 6.6 -67 38
NoneNone
PDSP KiDatabase 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
2601 3780 3H-SCH23390 25 Human Binding pKi = 7.6 7.6 -15 21
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
443951 3780 3H-SCH23390 25 Human Binding pKi = 7.6 7.6 -15 21
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
56 3780 3H-SCH23390 25 Human Binding pKi = 7.6 7.6 -15 21
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL73151 3780 3H-SCH23390 25 Human Binding pKi = 7.6 7.6 -15 21
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
DB13399 3780 3H-SCH23390 25 Human Binding pKi = 7.6 7.6 -15 21
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
135398737 958 3H-SCH23390 57 Human Binding pKi = 6.6 6.6 -89 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
135398737.0 958 3H-SCH23390 57 Human Binding pKi = 6.6 6.6 -89 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 958 3H-SCH23390 57 Human Binding pKi = 6.6 6.6 -89 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 958 3H-SCH23390 57 Human Binding pKi = 6.6 6.6 -89 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 958 3H-SCH23390 57 Human Binding pKi = 6.6 6.6 -89 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 958 3H-SCH23390 57 Human Binding pKi = 6.6 6.6 -89 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
5311189 207299 3H-SCH23390 9 Human Binding pKi = 5.6 5.6 -46 27
NoneNone
PDSP KiDatabase 219 3 1 2 3.0 CCCN1CCC[C@@H](c2cccc(O)c2)C1 None
CHEMBL7549 207299 3H-SCH23390 9 Human Binding pKi = 5.6 5.6 -46 27
NoneNone
PDSP KiDatabase 219 3 1 2 3.0 CCCN1CCC[C@@H](c2cccc(O)c2)C1 None
103 4153 3H-SCH23390 44 Human Binding pKi = 6.6 6.6 -33 53
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
2875 4153 3H-SCH23390 44 Human Binding pKi = 6.6 6.6 -33 53
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
5736 4153 3H-SCH23390 44 Human Binding pKi = 6.6 6.6 -33 53
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL285802 4153 3H-SCH23390 44 Human Binding pKi = 6.6 6.6 -33 53
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
DB09225 4153 3H-SCH23390 44 Human Binding pKi = 6.6 6.6 -33 53
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
135398737 958 3H-SCH23390 57 Human Binding pKi = 6.6 6.6 -89 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
135398737.0 958 3H-SCH23390 57 Human Binding pKi = 6.6 6.6 -89 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 958 3H-SCH23390 57 Human Binding pKi = 6.6 6.6 -89 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 958 3H-SCH23390 57 Human Binding pKi = 6.6 6.6 -89 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 958 3H-SCH23390 57 Human Binding pKi = 6.6 6.6 -89 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 958 3H-SCH23390 57 Human Binding pKi = 6.6 6.6 -89 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
1524 2181 3H-SCH23390 61 Human Binding pKi = 5.6 5.6 -234 51
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
197 2181 3H-SCH23390 61 Human Binding pKi = 5.6 5.6 -234 51
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
3822 2181 3H-SCH23390 61 Human Binding pKi = 5.6 5.6 -234 51
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
3822.0 2181 3H-SCH23390 61 Human Binding pKi = 5.6 5.6 -234 51
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
88 2181 3H-SCH23390 61 Human Binding pKi = 5.6 5.6 -234 51
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
CHEMBL51 2181 3H-SCH23390 61 Human Binding pKi = 5.6 5.6 -234 51
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
DB12465 2181 3H-SCH23390 61 Human Binding pKi = 5.6 5.6 -234 51
NoneNone
PDSP KiDatabase 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
242 470 3H-SCH23390 70 Human Binding pKi = 5.6 5.6 -380 51
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
34 470 3H-SCH23390 70 Human Binding pKi = 5.6 5.6 -380 51
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
60795 470 3H-SCH23390 70 Human Binding pKi = 5.6 5.6 -380 51
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
60795.0 470 3H-SCH23390 70 Human Binding pKi = 5.6 5.6 -380 51
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL1112 470 3H-SCH23390 70 Human Binding pKi = 5.6 5.6 -380 51
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
DB01238 470 3H-SCH23390 70 Human Binding pKi = 5.6 5.6 -380 51
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
11954259 218469 3H-SCH23390 0 Human Binding pKi = 6.6 6.6 -870 43
NoneNone
PDSP KiDatabase 443 5 0 5 3.5 CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C None
25212275 174525 UNDEFINED 0 Human Binding pKi = 6.6 6.6 -6309 6
NoneNone
PDSP KiDatabase 682 13 0 8 7.4 O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1 None
CHEMBL455288 174525 UNDEFINED 0 Human Binding pKi = 6.6 6.6 -6309 6
NoneNone
PDSP KiDatabase 682 13 0 8 7.4 O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1 None
25212276 190175 UNDEFINED 0 Human Binding pKi = 6.6 6.6 -741 6
NoneNone
PDSP KiDatabase 508 11 0 3 7.4 CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1 None
CHEMBL517244 190175 UNDEFINED 0 Human Binding pKi = 6.6 6.6 -741 6
NoneNone
PDSP KiDatabase 508 11 0 3 7.4 CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1 None
37459 746 3H-SCH23390 9 Human Binding pKi = 7.6 7.6 -61 24
NoneNone
PDSP KiDatabase 361 0 1 2 4.8 O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C None
62 746 3H-SCH23390 9 Human Binding pKi = 7.6 7.6 -61 24
NoneNone
PDSP KiDatabase 361 0 1 2 4.8 O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C None
CHEMBL8514 746 3H-SCH23390 9 Human Binding pKi = 7.6 7.6 -61 24
NoneNone
PDSP KiDatabase 361 0 1 2 4.8 O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C None
44591099 176294 UNDEFINED 0 Human Binding pKi = 6.6 6.6 -1023 6
NoneNone
PDSP KiDatabase 494 10 0 3 7.0 CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1 None
CHEMBL459350 176294 UNDEFINED 0 Human Binding pKi = 6.6 6.6 -1023 6
NoneNone
PDSP KiDatabase 494 10 0 3 7.0 CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1 None
135398737 958 3H-SCH23390 57 Human Binding pKi = 6.6 6.6 -89 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
135398737.0 958 3H-SCH23390 57 Human Binding pKi = 6.6 6.6 -89 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 958 3H-SCH23390 57 Human Binding pKi = 6.6 6.6 -89 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 958 3H-SCH23390 57 Human Binding pKi = 6.6 6.6 -89 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 958 3H-SCH23390 57 Human Binding pKi = 6.6 6.6 -89 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 958 3H-SCH23390 57 Human Binding pKi = 6.6 6.6 -89 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
135409468 2035 3H-SCH23390 50 Human Binding pKi = 6.6 6.6 -100 40
NoneNone
PDSP KiDatabase 312 1 2 4 1.7 Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 None
333 2035 3H-SCH23390 50 Human Binding pKi = 6.6 6.6 -100 40
NoneNone
PDSP KiDatabase 312 1 2 4 1.7 Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 None
CHEMBL845 2035 3H-SCH23390 50 Human Binding pKi = 6.6 6.6 -100 40
NoneNone
PDSP KiDatabase 312 1 2 4 1.7 Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 None
186 1807 3H-SCH23390 38 Human Binding pKi = 5.5 5.5 -380 16
NoneNone
PDSP KiDatabase 295 5 1 2 3.7 OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1 None
71781 1807 3H-SCH23390 38 Human Binding pKi = 5.5 5.5 -380 16
NoneNone
PDSP KiDatabase 295 5 1 2 3.7 OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1 None
CHEMBL18972 1807 3H-SCH23390 38 Human Binding pKi = 5.5 5.5 -380 16
NoneNone
PDSP KiDatabase 295 5 1 2 3.7 OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1 None
115237 55601 3H-SCH23390 68 Human Binding pKi = 7.5 7.5 -11 54
NoneNone
PDSP KiDatabase 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
115237.0 55601 3H-SCH23390 68 Human Binding pKi = 7.5 7.5 -11 54
NoneNone
PDSP KiDatabase 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
CHEMBL1621 55601 3H-SCH23390 68 Human Binding pKi = 7.5 7.5 -11 54
NoneNone
PDSP KiDatabase 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
DB01267 55601 3H-SCH23390 68 Human Binding pKi = 7.5 7.5 -11 54
NoneNone
PDSP KiDatabase 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
None 219647 UNDEFINED 0 Human Binding pKi = 6.5 6.5 -190 6
NoneNone
PDSP KiDatabase 532 10 0 4 8.0 CN(CCC=C1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl)CC4=CC=C(C=C4)OCCCN5CCCCC5 None
1588 2325 3H-SCH23390 21 Human Binding pKi = 8.5 8.5 -13 43
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
28864 2325 3H-SCH23390 21 Human Binding pKi = 8.5 8.5 -13 43
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
28864.0 2325 3H-SCH23390 21 Human Binding pKi = 8.5 8.5 -13 43
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
43 2325 3H-SCH23390 21 Human Binding pKi = 8.5 8.5 -13 43
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL157138 2325 3H-SCH23390 21 Human Binding pKi = 8.5 8.5 -13 43
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
DB00589 2325 3H-SCH23390 21 Human Binding pKi = 8.5 8.5 -13 43
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
100 3805 3H-SCH23390 44 Human Binding pKi = 6.5 6.5 -85 55
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
2637 3805 3H-SCH23390 44 Human Binding pKi = 6.5 6.5 -85 55
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
5452 3805 3H-SCH23390 44 Human Binding pKi = 6.5 6.5 -85 55
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
CHEMBL479 3805 3H-SCH23390 44 Human Binding pKi = 6.5 6.5 -85 55
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
DB00679 3805 3H-SCH23390 44 Human Binding pKi = 6.5 6.5 -85 55
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
5 139 3H-SCH23390 45 Human Binding pKi = 5.5 5.5 -7244 54
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
5202 139 3H-SCH23390 45 Human Binding pKi = 5.5 5.5 -7244 54
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
CHEMBL39 139 3H-SCH23390 45 Human Binding pKi = 5.5 5.5 -7244 54
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
DB08839 139 3H-SCH23390 45 Human Binding pKi = 5.5 5.5 -7244 54
NoneNone
PDSP KiDatabase 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 None
3294 2006 3H-SCH23390 61 Human Binding pKi = 6.5 6.5 -66 44
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
71360 2006 3H-SCH23390 61 Human Binding pKi = 6.5 6.5 -66 44
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
71360.0 2006 3H-SCH23390 61 Human Binding pKi = 6.5 6.5 -66 44
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
87 2006 3H-SCH23390 61 Human Binding pKi = 6.5 6.5 -66 44
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
CHEMBL14376 2006 3H-SCH23390 61 Human Binding pKi = 6.5 6.5 -66 44
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
DB04946 2006 3H-SCH23390 61 Human Binding pKi = 6.5 6.5 -66 44
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
2105 3054 3H-SCH23390 28 Human Binding pKi = 7.5 7.5 -125 33
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
47811 3054 3H-SCH23390 28 Human Binding pKi = 7.5 7.5 -125 33
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
48 3054 3H-SCH23390 28 Human Binding pKi = 7.5 7.5 -125 33
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
CHEMBL531 3054 3H-SCH23390 28 Human Binding pKi = 7.5 7.5 -125 33
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
DB01186 3054 3H-SCH23390 28 Human Binding pKi = 7.5 7.5 -125 33
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
1621 2429 3H-SCH23390 10 Rat Binding pKi = 6.5 6.5 -1096 44
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
17 2429 3H-SCH23390 10 Rat Binding pKi = 6.5 6.5 -1096 44
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
5761 2429 3H-SCH23390 10 Rat Binding pKi = 6.5 6.5 -1096 44
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL263881 2429 3H-SCH23390 10 Rat Binding pKi = 6.5 6.5 -1096 44
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
DB04829 2429 3H-SCH23390 10 Rat Binding pKi = 6.5 6.5 -1096 44
NoneNone
PDSP KiDatabase 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
104870 98934 3H-SCH23390 37 Human Binding pKi = 5.5 5.5 -7 21
NoneNone
PDSP KiDatabase 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 None
5374 98934 3H-SCH23390 37 Human Binding pKi = 5.5 5.5 -7 21
NoneNone
PDSP KiDatabase 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 None
CHEMBL279085 98934 3H-SCH23390 37 Human Binding pKi = 5.5 5.5 -7 21
NoneNone
PDSP KiDatabase 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 None
5018 3549 3H-SCH23390 8 Human Binding pKi = 7.5 7.5 -2 9
NoneNone
PDSP KiDatabase 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O None
943 3549 3H-SCH23390 8 Human Binding pKi = 7.5 7.5 -2 9
NoneNone
PDSP KiDatabase 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O None
946 3549 3H-SCH23390 8 Human Binding pKi = 7.5 7.5 -2 9
NoneNone
PDSP KiDatabase 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O None
CHEMBL13668 3549 3H-SCH23390 8 Human Binding pKi = 7.5 7.5 -2 9
NoneNone
PDSP KiDatabase 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O None
25058166 218450 3H-SCH23390 0 Human Binding pKi = 6.4 6.4 -37 26
NoneNone
PDSP KiDatabase 267 0 2 3 2.9 CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O None
6852389 218450 3H-SCH23390 0 Human Binding pKi = 6.4 6.4 -37 26
NoneNone
PDSP KiDatabase 267 0 2 3 2.9 CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O None
2402 3370 None 38 Human Binding pKi = 8.4 8.4 -81 25
NoneNone
Drug Central 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
5095 3370 None 38 Human Binding pKi = 8.4 8.4 -81 25
NoneNone
Drug Central 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
5095.0 3370 None 38 Human Binding pKi = 8.4 8.4 -81 25
NoneNone
Drug Central 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
7295 3370 None 38 Human Binding pKi = 8.4 8.4 -81 25
NoneNone
Drug Central 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
CHEMBL589 3370 None 38 Human Binding pKi = 8.4 8.4 -81 25
NoneNone
Drug Central 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
DB00268 3370 None 38 Human Binding pKi = 8.4 8.4 -81 25
NoneNone
Drug Central 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
6917970 3691 3H-SCH23390 40 Human Binding pKi = 8.4 8.4 1 34
NoneNone
PDSP KiDatabase 327 2 2 5 2.8 COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O None
8370 3691 3H-SCH23390 40 Human Binding pKi = 8.4 8.4 1 34
NoneNone
PDSP KiDatabase 327 2 2 5 2.8 COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O None
CHEMBL487387 3691 3H-SCH23390 40 Human Binding pKi = 8.4 8.4 1 34
NoneNone
PDSP KiDatabase 327 2 2 5 2.8 COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O None
4011 82440 UNDEFINED 34 Human Binding pKi = 6.4 6.4 -57 23
NoneNone
PDSP KiDatabase 277 4 1 1 4.2 CNCCCC12CCC(c3ccccc31)c1ccccc12 None
CHEMBL21731 82440 UNDEFINED 34 Human Binding pKi = 6.4 6.4 -57 23
NoneNone
PDSP KiDatabase 277 4 1 1 4.2 CNCCCC12CCC(c3ccccc31)c1ccccc12 None
2470 3653 3H-SCH23390 40 Human Binding pKi = 5.4 5.4 -14791 59
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3300 3653 3H-SCH23390 40 Human Binding pKi = 5.4 5.4 -14791 59
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5265 3653 3H-SCH23390 40 Human Binding pKi = 5.4 5.4 -14791 59
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
99 3653 3H-SCH23390 40 Human Binding pKi = 5.4 5.4 -14791 59
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL267930 3653 3H-SCH23390 40 Human Binding pKi = 5.4 5.4 -14791 59
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
31101 729 3H-SCH23390 28 Human Binding pKi = 6.3 6.3 -239 35
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
31101.0 729 3H-SCH23390 28 Human Binding pKi = 6.3 6.3 -239 35
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
35 729 3H-SCH23390 28 Human Binding pKi = 6.3 6.3 -239 35
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
403 729 3H-SCH23390 28 Human Binding pKi = 6.3 6.3 -239 35
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
CHEMBL493 729 3H-SCH23390 28 Human Binding pKi = 6.3 6.3 -239 35
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
DB01200 729 3H-SCH23390 28 Human Binding pKi = 6.3 6.3 -239 35
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
1353 1911 3H-SCH23390 63 Human Binding pKi = 7.3 7.3 -54 85
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 1911 3H-SCH23390 63 Human Binding pKi = 7.3 7.3 -54 85
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559.0 1911 3H-SCH23390 63 Human Binding pKi = 7.3 7.3 -54 85
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 1911 3H-SCH23390 63 Human Binding pKi = 7.3 7.3 -54 85
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 1911 3H-SCH23390 63 Human Binding pKi = 7.3 7.3 -54 85
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 1911 3H-SCH23390 63 Human Binding pKi = 7.3 7.3 -54 85
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
11154555 800 None 50 Human Binding pKi = 8.3 8.3 -724 24
Displacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranes
Drug Central 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl None
11154555.0 800 None 50 Human Binding pKi = 8.3 8.3 -724 24
Displacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranes
Drug Central 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl None
5037 800 None 50 Human Binding pKi = 8.3 8.3 -724 24
Displacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranes
Drug Central 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl None
7671 800 None 50 Human Binding pKi = 8.3 8.3 -724 24
Displacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranes
Drug Central 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL2028019 800 None 50 Human Binding pKi = 8.3 8.3 -724 24
Displacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranes
Drug Central 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL3085826 800 None 50 Human Binding pKi = 8.3 8.3 -724 24
Displacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranes
Drug Central 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl None
DB06016 800 None 50 Human Binding pKi = 8.3 8.3 -724 24
Displacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D5 receptor expressed in HEK293T cell membranes
Drug Central 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl None
2470 3653 None 40 Human Binding pKi = 8.3 8.3 -14791 59
NoneNone
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3300 3653 None 40 Human Binding pKi = 8.3 8.3 -14791 59
NoneNone
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5265 3653 None 40 Human Binding pKi = 8.3 8.3 -14791 59
NoneNone
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
99 3653 None 40 Human Binding pKi = 8.3 8.3 -14791 59
NoneNone
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL267930 3653 None 40 Human Binding pKi = 8.3 8.3 -14791 59
NoneNone
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
104870 98934 None 37 Human Binding pKi = 8.3 8.3 -7 21
NoneNone
Drug Central 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 None
5374 98934 None 37 Human Binding pKi = 8.3 8.3 -7 21
NoneNone
Drug Central 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 None
CHEMBL279085 98934 None 37 Human Binding pKi = 8.3 8.3 -7 21
NoneNone
Drug Central 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 None
1524 2181 None 61 Human Binding pKi = 8.3 8.3 -234 51
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
197 2181 None 61 Human Binding pKi = 8.3 8.3 -234 51
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
3822 2181 None 61 Human Binding pKi = 8.3 8.3 -234 51
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
3822.0 2181 None 61 Human Binding pKi = 8.3 8.3 -234 51
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
88 2181 None 61 Human Binding pKi = 8.3 8.3 -234 51
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
CHEMBL51 2181 None 61 Human Binding pKi = 8.3 8.3 -234 51
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
DB12465 2181 None 61 Human Binding pKi = 8.3 8.3 -234 51
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
100 3805 None 44 Human Binding pKi = 8.3 8.3 -85 55
NoneNone
Drug Central 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
2637 3805 None 44 Human Binding pKi = 8.3 8.3 -85 55
NoneNone
Drug Central 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
5452 3805 None 44 Human Binding pKi = 8.3 8.3 -85 55
NoneNone
Drug Central 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
CHEMBL479 3805 None 44 Human Binding pKi = 8.3 8.3 -85 55
NoneNone
Drug Central 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
DB00679 3805 None 44 Human Binding pKi = 8.3 8.3 -85 55
NoneNone
Drug Central 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
242 470 None 70 Human Binding pKi = 8.3 8.3 -380 51
NoneNone
Drug Central 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
34 470 None 70 Human Binding pKi = 8.3 8.3 -380 51
NoneNone
Drug Central 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
60795 470 None 70 Human Binding pKi = 8.3 8.3 -380 51
NoneNone
Drug Central 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
60795.0 470 None 70 Human Binding pKi = 8.3 8.3 -380 51
NoneNone
Drug Central 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL1112 470 None 70 Human Binding pKi = 8.3 8.3 -380 51
NoneNone
Drug Central 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
DB01238 470 None 70 Human Binding pKi = 8.3 8.3 -380 51
NoneNone
Drug Central 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
2337 3256 None 51 Human Binding pKi = 8.2 8.2 -27 62
NoneNone
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 3256 None 51 Human Binding pKi = 8.2 8.2 -27 62
NoneNone
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 3256 None 51 Human Binding pKi = 8.2 8.2 -27 62
NoneNone
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002.0 3256 None 51 Human Binding pKi = 8.2 8.2 -27 62
NoneNone
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 3256 None 51 Human Binding pKi = 8.2 8.2 -27 62
NoneNone
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 3256 None 51 Human Binding pKi = 8.2 8.2 -27 62
NoneNone
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
31101 729 3H-SCH23390 28 Human Binding pKi = 6.3 6.3 -239 35
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
31101.0 729 3H-SCH23390 28 Human Binding pKi = 6.3 6.3 -239 35
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
35 729 3H-SCH23390 28 Human Binding pKi = 6.3 6.3 -239 35
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
403 729 3H-SCH23390 28 Human Binding pKi = 6.3 6.3 -239 35
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
CHEMBL493 729 3H-SCH23390 28 Human Binding pKi = 6.3 6.3 -239 35
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
DB01200 729 3H-SCH23390 28 Human Binding pKi = 6.3 6.3 -239 35
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
2389 3331 3H-SCH23390 72 Human Binding pKi = 6.3 6.3 -234 67
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 3331 3H-SCH23390 72 Human Binding pKi = 6.3 6.3 -234 67
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073.0 3331 3H-SCH23390 72 Human Binding pKi = 6.3 6.3 -234 67
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 3331 3H-SCH23390 72 Human Binding pKi = 6.3 6.3 -234 67
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 3331 3H-SCH23390 72 Human Binding pKi = 6.3 6.3 -234 67
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 3331 3H-SCH23390 72 Human Binding pKi = 6.3 6.3 -234 67
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
2407 3372 None 50 Human Binding pKi = 8.2 8.2 -83 7
NoneNone
Drug Central 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 None
59227 3372 None 50 Human Binding pKi = 8.2 8.2 -83 7
NoneNone
Drug Central 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 None
59227.0 3372 None 50 Human Binding pKi = 8.2 8.2 -83 7
NoneNone
Drug Central 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 None
941 3372 None 50 Human Binding pKi = 8.2 8.2 -83 7
NoneNone
Drug Central 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 None
CHEMBL1303 3372 None 50 Human Binding pKi = 8.2 8.2 -83 7
NoneNone
Drug Central 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 None
DB05271 3372 None 50 Human Binding pKi = 8.2 8.2 -83 7
NoneNone
Drug Central 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 None
31101 729 None 28 Human Binding pKi = 8.2 8.2 -239 35
NoneNone
Drug Central 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
31101.0 729 None 28 Human Binding pKi = 8.2 8.2 -239 35
NoneNone
Drug Central 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
35 729 None 28 Human Binding pKi = 8.2 8.2 -239 35
NoneNone
Drug Central 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
403 729 None 28 Human Binding pKi = 8.2 8.2 -239 35
NoneNone
Drug Central 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
CHEMBL493 729 None 28 Human Binding pKi = 8.2 8.2 -239 35
NoneNone
Drug Central 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
DB01200 729 None 28 Human Binding pKi = 8.2 8.2 -239 35
NoneNone
Drug Central 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
4011 82440 None 34 Human Binding pKi = 8.2 8.2 -57 23
NoneNone
Drug Central 277 4 1 1 4.2 CNCCCC12CCC(c3ccccc31)c1ccccc12 None
CHEMBL21731 82440 None 34 Human Binding pKi = 8.2 8.2 -57 23
NoneNone
Drug Central 277 4 1 1 4.2 CNCCCC12CCC(c3ccccc31)c1ccccc12 None
7077 66980 None 21 Human Binding pKi = 8.2 8.2 -4 5
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
Drug Central 255 6 0 2 3.2 CN(C)CCOc1ccccc1Cc1ccccc1 None
CHEMBL186720 66980 None 21 Human Binding pKi = 8.2 8.2 -4 5
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
Drug Central 255 6 0 2 3.2 CN(C)CCOc1ccccc1Cc1ccccc1 None
CHEMBL3925724 66980 None 21 Human Binding pKi = 8.2 8.2 -4 5
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
Drug Central 255 6 0 2 3.2 CN(C)CCOc1ccccc1Cc1ccccc1 None
1621 2429 None 10 Human Binding pKi = 8.2 8.2 -151 44
Binding affinity towards Dopamine receptor D5Binding affinity towards Dopamine receptor D5
Drug Central 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
17 2429 None 10 Human Binding pKi = 8.2 8.2 -151 44
Binding affinity towards Dopamine receptor D5Binding affinity towards Dopamine receptor D5
Drug Central 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
5761 2429 None 10 Human Binding pKi = 8.2 8.2 -151 44
Binding affinity towards Dopamine receptor D5Binding affinity towards Dopamine receptor D5
Drug Central 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL263881 2429 None 10 Human Binding pKi = 8.2 8.2 -151 44
Binding affinity towards Dopamine receptor D5Binding affinity towards Dopamine receptor D5
Drug Central 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
DB04829 2429 None 10 Human Binding pKi = 8.2 8.2 -151 44
Binding affinity towards Dopamine receptor D5Binding affinity towards Dopamine receptor D5
Drug Central 323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
3294 2006 None 61 Human Binding pKi = 8.2 8.2 -66 44
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
71360 2006 None 61 Human Binding pKi = 8.2 8.2 -66 44
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
71360.0 2006 None 61 Human Binding pKi = 8.2 8.2 -66 44
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
87 2006 None 61 Human Binding pKi = 8.2 8.2 -66 44
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
CHEMBL14376 2006 None 61 Human Binding pKi = 8.2 8.2 -66 44
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
DB04946 2006 None 61 Human Binding pKi = 8.2 8.2 -66 44
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
212 3806 None 35 Human Binding pKi = 8.2 8.2 -6 25
NoneNone
Drug Central 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C None
2639 3806 None 35 Human Binding pKi = 8.2 8.2 -6 25
NoneNone
Drug Central 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C None
941651 3806 None 35 Human Binding pKi = 8.2 8.2 -6 25
NoneNone
Drug Central 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C None
941651.0 3806 None 35 Human Binding pKi = 8.2 8.2 -6 25
NoneNone
Drug Central 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C None
CHEMBL1201 3806 None 35 Human Binding pKi = 8.2 8.2 -6 25
NoneNone
Drug Central 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C None
DB01623 3806 None 35 Human Binding pKi = 8.2 8.2 -6 25
NoneNone
Drug Central 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C None
135398737 958 None 57 Human Binding pKi = 8.2 8.2 -89 91
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
135398737.0 958 None 57 Human Binding pKi = 8.2 8.2 -89 91
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 958 None 57 Human Binding pKi = 8.2 8.2 -89 91
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 958 None 57 Human Binding pKi = 8.2 8.2 -89 91
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 958 None 57 Human Binding pKi = 8.2 8.2 -89 91
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 958 None 57 Human Binding pKi = 8.2 8.2 -89 91
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
103 4153 None 44 Human Binding pKi = 8.2 8.2 -33 53
NoneNone
Drug Central 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
2875 4153 None 44 Human Binding pKi = 8.2 8.2 -33 53
NoneNone
Drug Central 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
5736 4153 None 44 Human Binding pKi = 8.2 8.2 -33 53
NoneNone
Drug Central 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL285802 4153 None 44 Human Binding pKi = 8.2 8.2 -33 53
NoneNone
Drug Central 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
DB09225 4153 None 44 Human Binding pKi = 8.2 8.2 -33 53
NoneNone
Drug Central 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
2105 3054 None 28 Human Binding pKi = 8.2 8.2 -125 33
NoneNone
Drug Central 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
47811 3054 None 28 Human Binding pKi = 8.2 8.2 -125 33
NoneNone
Drug Central 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
48 3054 None 28 Human Binding pKi = 8.2 8.2 -125 33
NoneNone
Drug Central 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
CHEMBL531 3054 None 28 Human Binding pKi = 8.2 8.2 -125 33
NoneNone
Drug Central 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
DB01186 3054 None 28 Human Binding pKi = 8.2 8.2 -125 33
NoneNone
Drug Central 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
180 401 None 38 Human Binding pKi = 8.2 8.2 -112 39
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
200 401 None 38 Human Binding pKi = 8.2 8.2 -112 39
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
2160 401 None 38 Human Binding pKi = 8.2 8.2 -112 39
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
2160.0 401 None 38 Human Binding pKi = 8.2 8.2 -112 39
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
CHEMBL629 401 None 38 Human Binding pKi = 8.2 8.2 -112 39
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
DB00321 401 None 38 Human Binding pKi = 8.2 8.2 -112 39
NoneNone
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
2865 4143 None 47 Human Binding pKi = 8.2 8.2 -64 53
NoneNone
Drug Central 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
59 4143 None 47 Human Binding pKi = 8.2 8.2 -64 53
NoneNone
Drug Central 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
60854 4143 None 47 Human Binding pKi = 8.2 8.2 -64 53
NoneNone
Drug Central 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
60854.0 4143 None 47 Human Binding pKi = 8.2 8.2 -64 53
NoneNone
Drug Central 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
CHEMBL708 4143 None 47 Human Binding pKi = 8.2 8.2 -64 53
NoneNone
Drug Central 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
DB00246 4143 None 47 Human Binding pKi = 8.2 8.2 -64 53
NoneNone
Drug Central 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
33630 179063 None 62 Human Binding pKi = 8.2 8.2 -5 27
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assay
Drug Central 523 7 1 2 7.5 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 None
CHEMBL47050 179063 None 62 Human Binding pKi = 8.2 8.2 -5 27
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assay
Drug Central 523 7 1 2 7.5 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 None
2726 919 None 48 Human Binding pKi = 8.2 8.2 -47 72
NoneNone
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
2726.0 919 None 48 Human Binding pKi = 8.2 8.2 -47 72
NoneNone
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 919 None 48 Human Binding pKi = 8.2 8.2 -47 72
NoneNone
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 919 None 48 Human Binding pKi = 8.2 8.2 -47 72
NoneNone
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 919 None 48 Human Binding pKi = 8.2 8.2 -47 72
NoneNone
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 919 None 48 Human Binding pKi = 8.2 8.2 -47 72
NoneNone
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
1153 1628 None 36 Human Binding pKi = 8.2 8.2 -22 10
NoneNone
Drug Central 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
12668023 1628 None 36 Human Binding pKi = 8.2 8.2 -22 10
NoneNone
Drug Central 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
30026874 1628 None 36 Human Binding pKi = 8.2 8.2 -22 10
NoneNone
Drug Central 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
30026875 1628 None 36 Human Binding pKi = 8.2 8.2 -22 10
NoneNone
Drug Central 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
3341 1628 None 36 Human Binding pKi = 8.2 8.2 -22 10
NoneNone
Drug Central 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
3341.0 1628 None 36 Human Binding pKi = 8.2 8.2 -22 10
NoneNone
Drug Central 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
6603851 1628 None 36 Human Binding pKi = 8.2 8.2 -22 10
NoneNone
Drug Central 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
933 1628 None 36 Human Binding pKi = 8.2 8.2 -22 10
NoneNone
Drug Central 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
939 1628 None 36 Human Binding pKi = 8.2 8.2 -22 10
NoneNone
Drug Central 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
985 1628 None 36 Human Binding pKi = 8.2 8.2 -22 10
NoneNone
Drug Central 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
CHEMBL1160786 1628 None 36 Human Binding pKi = 8.2 8.2 -22 10
NoneNone
Drug Central 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
CHEMBL1161520 1628 None 36 Human Binding pKi = 8.2 8.2 -22 10
NoneNone
Drug Central 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
CHEMBL588 1628 None 36 Human Binding pKi = 8.2 8.2 -22 10
NoneNone
Drug Central 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
DB00800 1628 None 36 Human Binding pKi = 8.2 8.2 -22 10
NoneNone
Drug Central 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
277 1301 3H-SCH23390 39 Human Binding pKi = 7.2 7.2 -72 49
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
2913 1301 3H-SCH23390 39 Human Binding pKi = 7.2 7.2 -72 49
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
2913.0 1301 3H-SCH23390 39 Human Binding pKi = 7.2 7.2 -72 49
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
765 1301 3H-SCH23390 39 Human Binding pKi = 7.2 7.2 -72 49
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
CHEMBL516 1301 3H-SCH23390 39 Human Binding pKi = 7.2 7.2 -72 49
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
DB00434 1301 3H-SCH23390 39 Human Binding pKi = 7.2 7.2 -72 49
NoneNone
PDSP KiDatabase 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
2389 3331 None 72 Human Binding pKi = 8.2 8.2 -234 67
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 3331 None 72 Human Binding pKi = 8.2 8.2 -234 67
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073.0 3331 None 72 Human Binding pKi = 8.2 8.2 -234 67
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 3331 None 72 Human Binding pKi = 8.2 8.2 -234 67
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 3331 None 72 Human Binding pKi = 8.2 8.2 -234 67
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 3331 None 72 Human Binding pKi = 8.2 8.2 -234 67
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
135398745 2914 None 65 Human Binding pKi = 8.2 8.2 -26 65
NoneNone
Drug Central 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
135398745.0 2914 None 65 Human Binding pKi = 8.2 8.2 -26 65
NoneNone
Drug Central 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 2914 None 65 Human Binding pKi = 8.2 8.2 -26 65
NoneNone
Drug Central 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 2914 None 65 Human Binding pKi = 8.2 8.2 -26 65
NoneNone
Drug Central 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 2914 None 65 Human Binding pKi = 8.2 8.2 -26 65
NoneNone
Drug Central 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
1613 2348 None 42 Human Binding pKi = 8.2 8.2 -5 44
NoneNone
Drug Central 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
205 2348 None 42 Human Binding pKi = 8.2 8.2 -5 44
NoneNone
Drug Central 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
3964 2348 None 42 Human Binding pKi = 8.2 8.2 -5 44
NoneNone
Drug Central 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
3964.0 2348 None 42 Human Binding pKi = 8.2 8.2 -5 44
NoneNone
Drug Central 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
CHEMBL831 2348 None 42 Human Binding pKi = 8.2 8.2 -5 44
NoneNone
Drug Central 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
DB00408 2348 None 42 Human Binding pKi = 8.2 8.2 -5 44
NoneNone
Drug Central 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
1353 1911 None 63 Human Binding pKi = 8.1 8.1 -54 85
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 1911 None 63 Human Binding pKi = 8.1 8.1 -54 85
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559.0 1911 None 63 Human Binding pKi = 8.1 8.1 -54 85
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 1911 None 63 Human Binding pKi = 8.1 8.1 -54 85
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 1911 None 63 Human Binding pKi = 8.1 8.1 -54 85
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 1911 None 63 Human Binding pKi = 8.1 8.1 -54 85
NoneNone
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
115237 55601 None 68 Human Binding pKi = 8.1 8.1 -11 54
NoneNone
Drug Central 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
115237.0 55601 None 68 Human Binding pKi = 8.1 8.1 -11 54
NoneNone
Drug Central 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
CHEMBL1621 55601 None 68 Human Binding pKi = 8.1 8.1 -11 54
NoneNone
Drug Central 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
DB01267 55601 None 68 Human Binding pKi = 8.1 8.1 -11 54
NoneNone
Drug Central 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
133538 3619 3H-SCH23390 21 Human Binding pKi = 8.1 8.1 -6 5
NoneNone
PDSP KiDatabase 317 1 2 3 3.7 CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O None
8443 3619 3H-SCH23390 21 Human Binding pKi = 8.1 8.1 -6 5
NoneNone
PDSP KiDatabase 317 1 2 3 3.7 CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O None
CHEMBL574558 3619 3H-SCH23390 21 Human Binding pKi = 8.1 8.1 -6 5
NoneNone
PDSP KiDatabase 317 1 2 3 3.7 CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O None
37 778 None 41 Human Binding pKi = 8.1 8.1 -5 17
NoneNone
Drug Central 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C None
460 778 None 41 Human Binding pKi = 8.1 8.1 -5 17
NoneNone
Drug Central 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C None
54746 778 None 41 Human Binding pKi = 8.1 8.1 -5 17
NoneNone
Drug Central 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C None
54746.0 778 None 41 Human Binding pKi = 8.1 8.1 -5 17
NoneNone
Drug Central 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C None
CHEMBL1201087 778 None 41 Human Binding pKi = 8.1 8.1 -5 17
NoneNone
Drug Central 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C None
DB00248 778 None 41 Human Binding pKi = 8.1 8.1 -5 17
NoneNone
Drug Central 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C None
228 445 None 20 Human Binding pKi = 8.1 8.1 -3 24
NoneNone
Drug Central 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O None
33 445 None 20 Human Binding pKi = 8.1 8.1 -3 24
NoneNone
Drug Central 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O None
6005 445 None 20 Human Binding pKi = 8.1 8.1 -3 24
NoneNone
Drug Central 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O None
6005.0 445 None 20 Human Binding pKi = 8.1 8.1 -3 24
NoneNone
Drug Central 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O None
CHEMBL53 445 None 20 Human Binding pKi = 8.1 8.1 -3 24
NoneNone
Drug Central 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O None
DB00714 445 None 20 Human Binding pKi = 8.1 8.1 -3 24
NoneNone
Drug Central 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O None
1212 1662 None 37 Human Binding pKi = 8.1 8.1 -28 65
NoneNone
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
204 1662 None 37 Human Binding pKi = 8.1 8.1 -28 65
NoneNone
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
3372 1662 None 37 Human Binding pKi = 8.1 8.1 -28 65
NoneNone
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
3372.0 1662 None 37 Human Binding pKi = 8.1 8.1 -28 65
NoneNone
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL726 1662 None 37 Human Binding pKi = 8.1 8.1 -28 65
NoneNone
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00623 1662 None 37 Human Binding pKi = 8.1 8.1 -28 65
NoneNone
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
3389 220197 None 0 Human Binding pKi = 8.1 8.1 -1 26
NoneNone
Drug Central 549 12 0 6 6.8 CCCCCCC(=O)OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1 None
135398745 2914 3H-SCH23390 65 Human Binding pKi = 7.1 7.1 -26 65
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
135398745.0 2914 3H-SCH23390 65 Human Binding pKi = 7.1 7.1 -26 65
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 2914 3H-SCH23390 65 Human Binding pKi = 7.1 7.1 -26 65
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 2914 3H-SCH23390 65 Human Binding pKi = 7.1 7.1 -26 65
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 2914 3H-SCH23390 65 Human Binding pKi = 7.1 7.1 -26 65
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
1613 2348 3H-SCH23390 42 Human Binding pKi = 7.1 7.1 -5 44
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
205 2348 3H-SCH23390 42 Human Binding pKi = 7.1 7.1 -5 44
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
3964 2348 3H-SCH23390 42 Human Binding pKi = 7.1 7.1 -5 44
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
3964.0 2348 3H-SCH23390 42 Human Binding pKi = 7.1 7.1 -5 44
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
CHEMBL831 2348 3H-SCH23390 42 Human Binding pKi = 7.1 7.1 -5 44
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
DB00408 2348 3H-SCH23390 42 Human Binding pKi = 7.1 7.1 -5 44
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
5281878 1660 3H-SCH23390 22 Human Binding pKi = 8.1 8.1 -3 16
NoneNone
PDSP KiDatabase 434 5 1 4 4.6 OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
5281881 1660 3H-SCH23390 22 Human Binding pKi = 8.1 8.1 -3 16
NoneNone
PDSP KiDatabase 434 5 1 4 4.6 OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
948 1660 3H-SCH23390 22 Human Binding pKi = 8.1 8.1 -3 16
NoneNone
PDSP KiDatabase 434 5 1 4 4.6 OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
968 1660 3H-SCH23390 22 Human Binding pKi = 8.1 8.1 -3 16
NoneNone
PDSP KiDatabase 434 5 1 4 4.6 OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL42055 1660 3H-SCH23390 22 Human Binding pKi = 8.1 8.1 -3 16
NoneNone
PDSP KiDatabase 434 5 1 4 4.6 OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL54661 1660 3H-SCH23390 22 Human Binding pKi = 8.1 8.1 -3 16
NoneNone
PDSP KiDatabase 434 5 1 4 4.6 OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00875 1660 3H-SCH23390 22 Human Binding pKi = 8.1 8.1 -3 16
NoneNone
PDSP KiDatabase 434 5 1 4 4.6 OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
11976 920 None 44 Human Binding pKi = 8.1 8.1 -8 23
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
Drug Central 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
667467 920 None 44 Human Binding pKi = 8.1 8.1 -8 23
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
Drug Central 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
667467.0 920 None 44 Human Binding pKi = 8.1 8.1 -8 23
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
Drug Central 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
CHEMBL908 920 None 44 Human Binding pKi = 8.1 8.1 -8 23
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
Drug Central 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
DB01239 920 None 44 Human Binding pKi = 8.1 8.1 -8 23
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
Drug Central 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
5281878 1660 None 22 Human Binding pKi = 8.1 8.1 -3 16
NoneNone
Drug Central 434 5 1 4 4.6 OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
5281881 1660 None 22 Human Binding pKi = 8.1 8.1 -3 16
NoneNone
Drug Central 434 5 1 4 4.6 OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
948 1660 None 22 Human Binding pKi = 8.1 8.1 -3 16
NoneNone
Drug Central 434 5 1 4 4.6 OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
968 1660 None 22 Human Binding pKi = 8.1 8.1 -3 16
NoneNone
Drug Central 434 5 1 4 4.6 OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL42055 1660 None 22 Human Binding pKi = 8.1 8.1 -3 16
NoneNone
Drug Central 434 5 1 4 4.6 OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL54661 1660 None 22 Human Binding pKi = 8.1 8.1 -3 16
NoneNone
Drug Central 434 5 1 4 4.6 OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00875 1660 None 22 Human Binding pKi = 8.1 8.1 -3 16
NoneNone
Drug Central 434 5 1 4 4.6 OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
1588 2325 None 21 Human Binding pKi = 8.1 8.1 -13 43
NoneNone
Drug Central 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
28864 2325 None 21 Human Binding pKi = 8.1 8.1 -13 43
NoneNone
Drug Central 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
28864.0 2325 None 21 Human Binding pKi = 8.1 8.1 -13 43
NoneNone
Drug Central 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
43 2325 None 21 Human Binding pKi = 8.1 8.1 -13 43
NoneNone
Drug Central 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL157138 2325 None 21 Human Binding pKi = 8.1 8.1 -13 43
NoneNone
Drug Central 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
DB00589 2325 None 21 Human Binding pKi = 8.1 8.1 -13 43
NoneNone
Drug Central 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
1242 3613 3H-SCH23390 17 Rat Binding pKi = 7.1 7.1 -4 17
NoneNone
PDSP KiDatabase 255 1 3 3 2.4 Oc1cc2CCNCC(c2cc1O)c1ccccc1 None
935 3613 3H-SCH23390 17 Rat Binding pKi = 7.1 7.1 -4 17
NoneNone
PDSP KiDatabase 255 1 3 3 2.4 Oc1cc2CCNCC(c2cc1O)c1ccccc1 None
CHEMBL286080 3613 3H-SCH23390 17 Rat Binding pKi = 7.1 7.1 -4 17
NoneNone
PDSP KiDatabase 255 1 3 3 2.4 Oc1cc2CCNCC(c2cc1O)c1ccccc1 None
1153 1628 3H-SCH23390 36 Human Binding pKi = 6.1 6.1 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
12668023 1628 3H-SCH23390 36 Human Binding pKi = 6.1 6.1 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
30026874 1628 3H-SCH23390 36 Human Binding pKi = 6.1 6.1 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
30026875 1628 3H-SCH23390 36 Human Binding pKi = 6.1 6.1 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
3341 1628 3H-SCH23390 36 Human Binding pKi = 6.1 6.1 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
3341.0 1628 3H-SCH23390 36 Human Binding pKi = 6.1 6.1 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
6603851 1628 3H-SCH23390 36 Human Binding pKi = 6.1 6.1 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
933 1628 3H-SCH23390 36 Human Binding pKi = 6.1 6.1 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
939 1628 3H-SCH23390 36 Human Binding pKi = 6.1 6.1 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
985 1628 3H-SCH23390 36 Human Binding pKi = 6.1 6.1 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
CHEMBL1160786 1628 3H-SCH23390 36 Human Binding pKi = 6.1 6.1 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
CHEMBL1161520 1628 3H-SCH23390 36 Human Binding pKi = 6.1 6.1 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
CHEMBL588 1628 3H-SCH23390 36 Human Binding pKi = 6.1 6.1 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
DB00800 1628 3H-SCH23390 36 Human Binding pKi = 6.1 6.1 -22 10
NoneNone
PDSP KiDatabase 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O None
681 1465 None 47 Human Binding pKi = 8.1 8.1 -67 38
NoneNone
Drug Central 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
681.0 1465 None 47 Human Binding pKi = 8.1 8.1 -67 38
NoneNone
Drug Central 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
940 1465 None 47 Human Binding pKi = 8.1 8.1 -67 38
NoneNone
Drug Central 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
947 1465 None 47 Human Binding pKi = 8.1 8.1 -67 38
NoneNone
Drug Central 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
CHEMBL59 1465 None 47 Human Binding pKi = 8.1 8.1 -67 38
NoneNone
Drug Central 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
DB00988 1465 None 47 Human Binding pKi = 8.1 8.1 -67 38
NoneNone
Drug Central 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O None
11976 920 UNDEFINED 44 Human Binding pKi = 8.1 8.1 -8 23
NoneNone
PDSP KiDatabase 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
667467 920 UNDEFINED 44 Human Binding pKi = 8.1 8.1 -8 23
NoneNone
PDSP KiDatabase 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
667467.0 920 UNDEFINED 44 Human Binding pKi = 8.1 8.1 -8 23
NoneNone
PDSP KiDatabase 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
CHEMBL908 920 UNDEFINED 44 Human Binding pKi = 8.1 8.1 -8 23
NoneNone
PDSP KiDatabase 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
DB01239 920 UNDEFINED 44 Human Binding pKi = 8.1 8.1 -8 23
NoneNone
PDSP KiDatabase 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl None
135398745 2914 3H-SCH23390 65 Human Binding pKi = 7.1 7.1 -26 65
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
135398745.0 2914 3H-SCH23390 65 Human Binding pKi = 7.1 7.1 -26 65
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 2914 3H-SCH23390 65 Human Binding pKi = 7.1 7.1 -26 65
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 2914 3H-SCH23390 65 Human Binding pKi = 7.1 7.1 -26 65
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 2914 3H-SCH23390 65 Human Binding pKi = 7.1 7.1 -26 65
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
None 218719 3H-SCH23390 0 Human Binding pKi = 6.0 6.0 -2 4
NoneNone
PDSP KiDatabase 226 0 2 2 1.4 C1CCC(=O)NCCCCCC(=O)NCC1 None
2105 3054 3H-SCH23390 28 Human Binding pKi = 6.0 6.0 -125 33
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
47811 3054 3H-SCH23390 28 Human Binding pKi = 6.0 6.0 -125 33
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
48 3054 3H-SCH23390 28 Human Binding pKi = 6.0 6.0 -125 33
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
CHEMBL531 3054 3H-SCH23390 28 Human Binding pKi = 6.0 6.0 -125 33
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
DB01186 3054 3H-SCH23390 28 Human Binding pKi = 6.0 6.0 -125 33
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
None 219619 UNDEFINED 0 Human Binding pKi = 6.0 6.0 -281 11
NoneNone
PDSP KiDatabase 116 4 0 2 1.4 CCCCN(C)N=O None
None 218720 3H-SCH23390 0 Human Binding pKi = 6.0 6.0 -1380 3
NoneNone
PDSP KiDatabase 315 6 1 3 4.3 CCCN(CCC1=CC=CS1)C2CCC3=C(C2)C=CC=C3O None
681 1465 None 47 Human Binding pKi = 6.6 6.6 -67 38
UnclassifiedUnclassified
Guide to Pharmacology 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 1826762
681.0 1465 None 47 Human Binding pKi = 6.6 6.6 -67 38
UnclassifiedUnclassified
Guide to Pharmacology 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 1826762
940 1465 None 47 Human Binding pKi = 6.6 6.6 -67 38
UnclassifiedUnclassified
Guide to Pharmacology 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 1826762
947 1465 None 47 Human Binding pKi = 6.6 6.6 -67 38
UnclassifiedUnclassified
Guide to Pharmacology 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 1826762
CHEMBL59 1465 None 47 Human Binding pKi = 6.6 6.6 -67 38
UnclassifiedUnclassified
Guide to Pharmacology 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 1826762
DB00988 1465 None 47 Human Binding pKi = 6.6 6.6 -67 38
UnclassifiedUnclassified
Guide to Pharmacology 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 1826762
1242 3613 None 17 Human Binding pKi = 7 7.0 -6 17
UnclassifiedUnclassified
Guide to Pharmacology 255 1 3 3 2.4 Oc1cc2CCNCC(c2cc1O)c1ccccc1 1826762
935 3613 None 17 Human Binding pKi = 7 7.0 -6 17
UnclassifiedUnclassified
Guide to Pharmacology 255 1 3 3 2.4 Oc1cc2CCNCC(c2cc1O)c1ccccc1 1826762
CHEMBL286080 3613 None 17 Human Binding pKi = 7 7.0 -6 17
UnclassifiedUnclassified
Guide to Pharmacology 255 1 3 3 2.4 Oc1cc2CCNCC(c2cc1O)c1ccccc1 1826762
107930 1529 None 25 Human Binding pKi = 8.3 8.3 -1 6
UnclassifiedUnclassified
Guide to Pharmacology 313 0 1 2 4.0 CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O 1826762
107930.0 1529 None 25 Human Binding pKi = 8.3 8.3 -1 6
UnclassifiedUnclassified
Guide to Pharmacology 313 0 1 2 4.0 CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O 1826762
3304 1529 None 25 Human Binding pKi = 8.3 8.3 -1 6
UnclassifiedUnclassified
Guide to Pharmacology 313 0 1 2 4.0 CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O 1826762
CHEMBL298406 1529 None 25 Human Binding pKi = 8.3 8.3 -1 6
UnclassifiedUnclassified
Guide to Pharmacology 313 0 1 2 4.0 CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O 1826762
DB12273 1529 None 25 Human Binding pKi = 8.3 8.3 -1 6
UnclassifiedUnclassified
Guide to Pharmacology 313 0 1 2 4.0 CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O 1826762
5018 3549 None 8 Human Binding pKi = 8.5 8.5 -2 9
UnclassifiedUnclassified
Guide to Pharmacology 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O 1826762
943 3549 None 8 Human Binding pKi = 8.5 8.5 -2 9
UnclassifiedUnclassified
Guide to Pharmacology 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O 1826762
946 3549 None 8 Human Binding pKi = 8.5 8.5 -2 9
UnclassifiedUnclassified
Guide to Pharmacology 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O 1826762
CHEMBL13668 3549 None 8 Human Binding pKi = 8.5 8.5 -2 9
UnclassifiedUnclassified
Guide to Pharmacology 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O 1826762
1243 3618 None 30 Human Binding pKi = 9.4 9.4 -2 15
UnclassifiedUnclassified
Guide to Pharmacology 331 1 1 2 3.8 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O 1826762
944 3618 None 30 Human Binding pKi = 9.4 9.4 -2 15
UnclassifiedUnclassified
Guide to Pharmacology 331 1 1 2 3.8 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O 1826762
CHEMBL324017 3618 None 30 Human Binding pKi = 9.4 9.4 -2 15
UnclassifiedUnclassified
Guide to Pharmacology 331 1 1 2 3.8 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O 1826762
11954224 218443 None 0 Human Binding pKi None 8.2 8.2 -478 59
NoneNone
Drug Central 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
3251 218443 None 0 Human Binding pKi None 8.2 8.2 -478 59
NoneNone
Drug Central 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
3251.0 218443 None 0 Human Binding pKi None 8.2 8.2 -478 59
NoneNone
Drug Central 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
CHEMBL1982133 218443 None 0 Human Binding pKi None 8.2 8.2 -478 59
NoneNone
Drug Central 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
DB00696 218443 None 0 Human Binding pKi None 8.2 8.2 -478 59
NoneNone
Drug Central 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
2601 3780 None 25 Human Binding pKi None 8.1 8.1 -15 21
NoneNone
Drug Central 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
443951 3780 None 25 Human Binding pKi None 8.1 8.1 -15 21
NoneNone
Drug Central 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
56 3780 None 25 Human Binding pKi None 8.1 8.1 -15 21
NoneNone
Drug Central 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL73151 3780 None 25 Human Binding pKi None 8.1 8.1 -15 21
NoneNone
Drug Central 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
DB13399 3780 None 25 Human Binding pKi None 8.1 8.1 -15 21
NoneNone
Drug Central 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
3036780 107587 None 16 Human Binding pKi None 8.1 8.1 -77 53
NoneNone
Drug Central 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
3036780.0 107587 None 16 Human Binding pKi None 8.1 8.1 -77 53
NoneNone
Drug Central 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
46780481 107587 None 16 Human Binding pKi None 8.1 8.1 -77 53
NoneNone
Drug Central 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
9903970 107587 None 16 Human Binding pKi None 8.1 8.1 -77 53
NoneNone
Drug Central 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
9903970.0 107587 None 16 Human Binding pKi None 8.1 8.1 -77 53
NoneNone
Drug Central 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL3187365 107587 None 16 Human Binding pKi None 8.1 8.1 -77 53
NoneNone
Drug Central 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL3544974 107587 None 16 Human Binding pKi None 8.1 8.1 -77 53
NoneNone
Drug Central 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL504548 107587 None 16 Human Binding pKi None 8.1 8.1 -77 53
NoneNone
Drug Central 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
DB06216 107587 None 16 Human Binding pKi None 8.1 8.1 -77 53
NoneNone
Drug Central 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
484 2858 None 34 Human Binding pKi None 4.9 4.9 -112 35
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O 1826762
951 2858 None 34 Human Binding pKi None 4.9 4.9 -112 35
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O 1826762
CHEMBL432 2858 None 34 Human Binding pKi None 4.9 4.9 -112 35
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O 1826762
2470 3653 None 40 Human Binding pKi None 5.3 5.3 -14791 59
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 1826762
3300 3653 None 40 Human Binding pKi None 5.3 5.3 -14791 59
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 1826762
5265 3653 None 40 Human Binding pKi None 5.3 5.3 -14791 59
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 1826762
99 3653 None 40 Human Binding pKi None 5.3 5.3 -14791 59
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 1826762
CHEMBL267930 3653 None 40 Human Binding pKi None 5.3 5.3 -14791 59
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 1826762
5 139 None 45 Human Binding pKi None 5.5 5.5 -7244 54
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 1826762
5202 139 None 45 Human Binding pKi None 5.5 5.5 -7244 54
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 1826762
CHEMBL39 139 None 45 Human Binding pKi None 5.5 5.5 -7244 54
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 1826762
DB08839 139 None 45 Human Binding pKi None 5.5 5.5 -7244 54
UnclassifiedUnclassified
Guide to Pharmacology 176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2 1826762
1524 2181 None 61 Human Binding pKi None 5.6 5.6 -234 51
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 1826762
197 2181 None 61 Human Binding pKi None 5.6 5.6 -234 51
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 1826762
3822 2181 None 61 Human Binding pKi None 5.6 5.6 -234 51
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 1826762
3822.0 2181 None 61 Human Binding pKi None 5.6 5.6 -234 51
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 1826762
88 2181 None 61 Human Binding pKi None 5.6 5.6 -234 51
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 1826762
CHEMBL51 2181 None 61 Human Binding pKi None 5.6 5.6 -234 51
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 1826762
DB12465 2181 None 61 Human Binding pKi None 5.6 5.6 -234 51
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 1826762
100 3805 None 44 Human Binding pKi None 5.6 5.6 -85 55
UnclassifiedUnclassified
Guide to Pharmacology 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 1826762
2637 3805 None 44 Human Binding pKi None 5.6 5.6 -85 55
UnclassifiedUnclassified
Guide to Pharmacology 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 1826762
5452 3805 None 44 Human Binding pKi None 5.6 5.6 -85 55
UnclassifiedUnclassified
Guide to Pharmacology 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 1826762
CHEMBL479 3805 None 44 Human Binding pKi None 5.6 5.6 -85 55
UnclassifiedUnclassified
Guide to Pharmacology 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 1826762
DB00679 3805 None 44 Human Binding pKi None 5.6 5.6 -85 55
UnclassifiedUnclassified
Guide to Pharmacology 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 1826762
30137 2877 None 0 Human Binding pKi None 5.9 5.9 -3019 10
UnclassifiedUnclassified
Guide to Pharmacology 295 2 2 3 3.6 CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O 1826762
8594 2877 None 0 Human Binding pKi None 5.9 5.9 -3019 10
UnclassifiedUnclassified
Guide to Pharmacology 295 2 2 3 3.6 CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O 1826762
934 2877 None 0 Human Binding pKi None 5.9 5.9 -3019 10
UnclassifiedUnclassified
Guide to Pharmacology 295 2 2 3 3.6 CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O 1826762
3153 297 None 18 Human Binding pKi None 6 6.0 -588 7
UnclassifiedUnclassified
Guide to Pharmacology 179 0 3 3 0.9 NC1CCc2c(C1)cc(c(c2)O)O 1826762
932 297 None 18 Human Binding pKi None 6 6.0 -588 7
UnclassifiedUnclassified
Guide to Pharmacology 179 0 3 3 0.9 NC1CCc2c(C1)cc(c(c2)O)O 1826762
CHEMBL26736 297 None 18 Human Binding pKi None 6 6.0 -588 7
UnclassifiedUnclassified
Guide to Pharmacology 179 0 3 3 0.9 NC1CCc2c(C1)cc(c(c2)O)O 1826762
2407 3372 None 50 Human Binding pKi None 6 6.0 -83 7
UnclassifiedUnclassified
Guide to Pharmacology 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 1826762
59227 3372 None 50 Human Binding pKi None 6 6.0 -83 7
UnclassifiedUnclassified
Guide to Pharmacology 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 1826762
59227.0 3372 None 50 Human Binding pKi None 6 6.0 -83 7
UnclassifiedUnclassified
Guide to Pharmacology 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 1826762
941 3372 None 50 Human Binding pKi None 6 6.0 -83 7
UnclassifiedUnclassified
Guide to Pharmacology 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 1826762
CHEMBL1303 3372 None 50 Human Binding pKi None 6 6.0 -83 7
UnclassifiedUnclassified
Guide to Pharmacology 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 1826762
DB05271 3372 None 50 Human Binding pKi None 6 6.0 -83 7
UnclassifiedUnclassified
Guide to Pharmacology 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 1826762
1153 1628 None 36 Human Binding pKi None 6.1 6.1 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
12668023 1628 None 36 Human Binding pKi None 6.1 6.1 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
30026874 1628 None 36 Human Binding pKi None 6.1 6.1 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
30026875 1628 None 36 Human Binding pKi None 6.1 6.1 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
3341 1628 None 36 Human Binding pKi None 6.1 6.1 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
3341.0 1628 None 36 Human Binding pKi None 6.1 6.1 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
6603851 1628 None 36 Human Binding pKi None 6.1 6.1 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
933 1628 None 36 Human Binding pKi None 6.1 6.1 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
939 1628 None 36 Human Binding pKi None 6.1 6.1 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
985 1628 None 36 Human Binding pKi None 6.1 6.1 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
CHEMBL1160786 1628 None 36 Human Binding pKi None 6.1 6.1 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
CHEMBL1161520 1628 None 36 Human Binding pKi None 6.1 6.1 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
CHEMBL588 1628 None 36 Human Binding pKi None 6.1 6.1 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
DB00800 1628 None 36 Human Binding pKi None 6.1 6.1 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
31101 729 None 28 Human Binding pKi None 6.3 6.3 -239 35
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 12388666
31101 729 None 28 Human Binding pKi None 6.3 6.3 -239 35
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 1826762
31101.0 729 None 28 Human Binding pKi None 6.3 6.3 -239 35
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 12388666
31101.0 729 None 28 Human Binding pKi None 6.3 6.3 -239 35
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 1826762
35 729 None 28 Human Binding pKi None 6.3 6.3 -239 35
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 12388666
35 729 None 28 Human Binding pKi None 6.3 6.3 -239 35
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 1826762
403 729 None 28 Human Binding pKi None 6.3 6.3 -239 35
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 12388666
403 729 None 28 Human Binding pKi None 6.3 6.3 -239 35
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 1826762
CHEMBL493 729 None 28 Human Binding pKi None 6.3 6.3 -239 35
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 12388666
CHEMBL493 729 None 28 Human Binding pKi None 6.3 6.3 -239 35
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 1826762
DB01200 729 None 28 Human Binding pKi None 6.3 6.3 -239 35
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 12388666
DB01200 729 None 28 Human Binding pKi None 6.3 6.3 -239 35
UnclassifiedUnclassified
Guide to Pharmacology 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 1826762
1353 1911 None 63 Human Binding pKi None 6.3 6.3 -54 85
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 1826762
3559 1911 None 63 Human Binding pKi None 6.3 6.3 -54 85
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 1826762
3559.0 1911 None 63 Human Binding pKi None 6.3 6.3 -54 85
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 1826762
86 1911 None 63 Human Binding pKi None 6.3 6.3 -54 85
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 1826762
CHEMBL54 1911 None 63 Human Binding pKi None 6.3 6.3 -54 85
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 1826762
DB00502 1911 None 63 Human Binding pKi None 6.3 6.3 -54 85
UnclassifiedUnclassified
Guide to Pharmacology 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 1826762
937 3615 None 0 Human Binding pKi None 6.3 6.3 1 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1826762
135398737 958 None 57 Human Binding pKi None 6.6 6.6 -89 91
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 1826762
135398737.0 958 None 57 Human Binding pKi None 6.6 6.6 -89 91
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 1826762
38 958 None 57 Human Binding pKi None 6.6 6.6 -89 91
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 1826762
722 958 None 57 Human Binding pKi None 6.6 6.6 -89 91
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 1826762
CHEMBL42 958 None 57 Human Binding pKi None 6.6 6.6 -89 91
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 1826762
DB00363 958 None 57 Human Binding pKi None 6.6 6.6 -89 91
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 1826762
2105 3054 None 28 Human Binding pKi None 6.8 6.8 -125 33
UnclassifiedUnclassified
Guide to Pharmacology 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 12388666
2105 3054 None 28 Human Binding pKi None 6.8 6.8 -125 33
UnclassifiedUnclassified
Guide to Pharmacology 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 1826762
47811 3054 None 28 Human Binding pKi None 6.8 6.8 -125 33
UnclassifiedUnclassified
Guide to Pharmacology 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 12388666
47811 3054 None 28 Human Binding pKi None 6.8 6.8 -125 33
UnclassifiedUnclassified
Guide to Pharmacology 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 1826762
48 3054 None 28 Human Binding pKi None 6.8 6.8 -125 33
UnclassifiedUnclassified
Guide to Pharmacology 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 12388666
48 3054 None 28 Human Binding pKi None 6.8 6.8 -125 33
UnclassifiedUnclassified
Guide to Pharmacology 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 1826762
CHEMBL531 3054 None 28 Human Binding pKi None 6.8 6.8 -125 33
UnclassifiedUnclassified
Guide to Pharmacology 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 12388666
CHEMBL531 3054 None 28 Human Binding pKi None 6.8 6.8 -125 33
UnclassifiedUnclassified
Guide to Pharmacology 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 1826762
DB01186 3054 None 28 Human Binding pKi None 6.8 6.8 -125 33
UnclassifiedUnclassified
Guide to Pharmacology 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 12388666
DB01186 3054 None 28 Human Binding pKi None 6.8 6.8 -125 33
UnclassifiedUnclassified
Guide to Pharmacology 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 1826762
161309 613 None 0 Human Binding pKi None 6.9 6.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology 575 5 3 6 2.4 CC[C@@H]([C@@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C 1826762
988 613 None 0 Human Binding pKi None 6.9 6.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology 575 5 3 6 2.4 CC[C@@H]([C@@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C 1826762
2726 919 None 48 Human Binding pKi None 6.9 6.9 -47 72
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 1826762
2726.0 919 None 48 Human Binding pKi None 6.9 6.9 -47 72
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 1826762
621 919 None 48 Human Binding pKi None 6.9 6.9 -47 72
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 1826762
83 919 None 48 Human Binding pKi None 6.9 6.9 -47 72
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 1826762
CHEMBL71 919 None 48 Human Binding pKi None 6.9 6.9 -47 72
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 1826762
DB00477 919 None 48 Human Binding pKi None 6.9 6.9 -47 72
UnclassifiedUnclassified
Guide to Pharmacology 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 1826762
228 445 None 20 Human Binding pKi None 7.1 7.1 -3 24
UnclassifiedUnclassified
Guide to Pharmacology 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 12388666
228 445 None 20 Human Binding pKi None 7.1 7.1 -3 24
UnclassifiedUnclassified
Guide to Pharmacology 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 1826762
33 445 None 20 Human Binding pKi None 7.1 7.1 -3 24
UnclassifiedUnclassified
Guide to Pharmacology 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 12388666
33 445 None 20 Human Binding pKi None 7.1 7.1 -3 24
UnclassifiedUnclassified
Guide to Pharmacology 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 1826762
6005 445 None 20 Human Binding pKi None 7.1 7.1 -3 24
UnclassifiedUnclassified
Guide to Pharmacology 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 12388666
6005 445 None 20 Human Binding pKi None 7.1 7.1 -3 24
UnclassifiedUnclassified
Guide to Pharmacology 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 1826762
6005.0 445 None 20 Human Binding pKi None 7.1 7.1 -3 24
UnclassifiedUnclassified
Guide to Pharmacology 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 12388666
6005.0 445 None 20 Human Binding pKi None 7.1 7.1 -3 24
UnclassifiedUnclassified
Guide to Pharmacology 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 1826762
CHEMBL53 445 None 20 Human Binding pKi None 7.1 7.1 -3 24
UnclassifiedUnclassified
Guide to Pharmacology 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 12388666
CHEMBL53 445 None 20 Human Binding pKi None 7.1 7.1 -3 24
UnclassifiedUnclassified
Guide to Pharmacology 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 1826762
DB00714 445 None 20 Human Binding pKi None 7.1 7.1 -3 24
UnclassifiedUnclassified
Guide to Pharmacology 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 12388666
DB00714 445 None 20 Human Binding pKi None 7.1 7.1 -3 24
UnclassifiedUnclassified
Guide to Pharmacology 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 1826762
37459 746 None 9 Human Binding pKi None 7.6 7.6 -61 24
UnclassifiedUnclassified
Guide to Pharmacology 361 0 1 2 4.8 O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C 1826762
62 746 None 9 Human Binding pKi None 7.6 7.6 -61 24
UnclassifiedUnclassified
Guide to Pharmacology 361 0 1 2 4.8 O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C 1826762
CHEMBL8514 746 None 9 Human Binding pKi None 7.6 7.6 -61 24
UnclassifiedUnclassified
Guide to Pharmacology 361 0 1 2 4.8 O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C 1826762
37 778 None 41 Human Binding pKi None 7.7 7.7 -5 17
UnclassifiedUnclassified
Guide to Pharmacology 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C 12388666
460 778 None 41 Human Binding pKi None 7.7 7.7 -5 17
UnclassifiedUnclassified
Guide to Pharmacology 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C 12388666
54746 778 None 41 Human Binding pKi None 7.7 7.7 -5 17
UnclassifiedUnclassified
Guide to Pharmacology 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C 12388666
54746.0 778 None 41 Human Binding pKi None 7.7 7.7 -5 17
UnclassifiedUnclassified
Guide to Pharmacology 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C 12388666
CHEMBL1201087 778 None 41 Human Binding pKi None 7.7 7.7 -5 17
UnclassifiedUnclassified
Guide to Pharmacology 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C 12388666
DB00248 778 None 41 Human Binding pKi None 7.7 7.7 -5 17
UnclassifiedUnclassified
Guide to Pharmacology 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C 12388666
1153 1628 None 36 Human Binding pKi None 7.8 7.8 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
12668023 1628 None 36 Human Binding pKi None 7.8 7.8 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
30026874 1628 None 36 Human Binding pKi None 7.8 7.8 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
30026875 1628 None 36 Human Binding pKi None 7.8 7.8 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
3341 1628 None 36 Human Binding pKi None 7.8 7.8 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
3341.0 1628 None 36 Human Binding pKi None 7.8 7.8 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
6603851 1628 None 36 Human Binding pKi None 7.8 7.8 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
933 1628 None 36 Human Binding pKi None 7.8 7.8 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
939 1628 None 36 Human Binding pKi None 7.8 7.8 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
985 1628 None 36 Human Binding pKi None 7.8 7.8 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
CHEMBL1160786 1628 None 36 Human Binding pKi None 7.8 7.8 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
CHEMBL1161520 1628 None 36 Human Binding pKi None 7.8 7.8 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
CHEMBL588 1628 None 36 Human Binding pKi None 7.8 7.8 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
DB00800 1628 None 36 Human Binding pKi None 7.8 7.8 -22 10
UnclassifiedUnclassified
Guide to Pharmacology 305 1 4 4 2.7 Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O 1826762
1212 1662 None 37 Human Binding pKi None 7.9 7.9 -28 65
UnclassifiedUnclassified
Guide to Pharmacology 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 1826762
204 1662 None 37 Human Binding pKi None 7.9 7.9 -28 65
UnclassifiedUnclassified
Guide to Pharmacology 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 1826762
3372 1662 None 37 Human Binding pKi None 7.9 7.9 -28 65
UnclassifiedUnclassified
Guide to Pharmacology 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 1826762
3372.0 1662 None 37 Human Binding pKi None 7.9 7.9 -28 65
UnclassifiedUnclassified
Guide to Pharmacology 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 1826762
CHEMBL726 1662 None 37 Human Binding pKi None 7.9 7.9 -28 65
UnclassifiedUnclassified
Guide to Pharmacology 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 1826762
DB00623 1662 None 37 Human Binding pKi None 7.9 7.9 -28 65
UnclassifiedUnclassified
Guide to Pharmacology 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 1826762
5281878 1660 None 22 Human Binding pKi None 8.1 8.1 -3 16
UnclassifiedUnclassified
Guide to Pharmacology 434 5 1 4 4.6 OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F 1826762
5281881 1660 None 22 Human Binding pKi None 8.1 8.1 -3 16
UnclassifiedUnclassified
Guide to Pharmacology 434 5 1 4 4.6 OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F 1826762
948 1660 None 22 Human Binding pKi None 8.1 8.1 -3 16
UnclassifiedUnclassified
Guide to Pharmacology 434 5 1 4 4.6 OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F 1826762
968 1660 None 22 Human Binding pKi None 8.1 8.1 -3 16
UnclassifiedUnclassified
Guide to Pharmacology 434 5 1 4 4.6 OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F 1826762
CHEMBL42055 1660 None 22 Human Binding pKi None 8.1 8.1 -3 16
UnclassifiedUnclassified
Guide to Pharmacology 434 5 1 4 4.6 OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F 1826762
CHEMBL54661 1660 None 22 Human Binding pKi None 8.1 8.1 -3 16
UnclassifiedUnclassified
Guide to Pharmacology 434 5 1 4 4.6 OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F 1826762
DB00875 1660 None 22 Human Binding pKi None 8.1 8.1 -3 16
UnclassifiedUnclassified
Guide to Pharmacology 434 5 1 4 4.6 OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F 1826762
1588 2325 None 21 Human Binding pKi None 8.5 8.5 -13 43
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 12388666
28864 2325 None 21 Human Binding pKi None 8.5 8.5 -13 43
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 12388666
28864.0 2325 None 21 Human Binding pKi None 8.5 8.5 -13 43
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 12388666
43 2325 None 21 Human Binding pKi None 8.5 8.5 -13 43
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 12388666
CHEMBL157138 2325 None 21 Human Binding pKi None 8.5 8.5 -13 43
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 12388666
DB00589 2325 None 21 Human Binding pKi None 8.5 8.5 -13 43
UnclassifiedUnclassified
Guide to Pharmacology 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC 12388666